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https://www.readbyqxmd.com/read/28723981/intestinal-microbiota-in-digestive-diseases
#1
Maria do Carmo Friche Passos, Joaquim Prado Moraes-Filho
BACKGROUND: In recent years, especially after the development of sophisticated metagenomic studies, research on the intestinal microbiota has increased, radically transforming our knowledge about the microbiome and its association with health maintenance and disease development in humans. Increasing evidence has shown that a permanent alteration in microbiota composition or function (dysbiosis) can alter immune responses, metabolism, intestinal permeability, and digestive motility, thereby promoting a proinflammatory state...
July 6, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28706428/appropriateness-of-the-study-of-iron-deficiency-anemia-prior-to-referral-for-small-bowel-evaluation-at-a-tertiary-center
#2
Jaime Pereira Rodrigues, Rolando Pinho, Joana Silva, Ana Ponte, Mafalda Sousa, João Carlos Silva, João Carvalho
AIM: To evaluate the adequacy of the study of iron deficiency anemia (IDA) in real life practice prior to referral to a gastroenterology department for small bowel evaluation. METHODS: All consecutive patients referred to a gastroenterology department for small bowel investigation due to iron deficiency anemia, between January 2013 and December 2015 were included. Both patients referred from general practitioners or directly from different hospital departments were selected...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28702130/new-insights-in-ibs-like-disorders-pandora-s-box-has-been-opened-a-review
#3
REVIEW
Raffaele Borghini, Giuseppe Donato, Domenico Alvaro, Antonio Picarelli
The most complained gastrointestinal symptoms are chronic diarrhea, bloating and abdominal pain. Once malignancies and inflammatory bowel diseases are excluded, irritable bowel syndrome (IBS) and the so called "IBS-like disorders" should be taken into account. The relationship between IBS as defined by Rome IV criteria and these clinical conditions is sometimes obscure, since many IBS patients identify food as a possible trigger for their symptoms. Here, we discuss IBS and the most common IBS-like disorders (celiac disease, non-celiac gluten sensitivity, fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs), lactose intolerance, small intestinal bacterial overgrowth (SIBO), α-amylase/trypsin inhibitor (ATIs), nickel allergic contact mucositis), focusing on epidemiologic, clinical, diagnostic and therapeutic aspects...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28700116/an-integrative-literature-review-exploring-the-clinical-management-of-delirium-in-patients-with-advanced-cancer
#4
REVIEW
Hayley Lawley, Alistair Hewison
AIM: The aim of this paper is to present the findings of an integrative literature review of the evidence for the clinical management of delirium in patients with advanced cancer. BACKGROUND: Patients with advanced cancer frequently experience delirium which can be distressing for both patients and their families. Current guidelines recommend that underlying causes of the delirium be addressed and a course of antipsychotics considered. However the research into the effectiveness of treatments for delirium in people with advanced cancer is limited...
July 12, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28695483/diagnosis-and-management-of-treatment-refractory-hypothyroidism-an-expert-consensus-report
#5
REVIEW
M Centanni, S Benvenga, I Sachmechi
There is a frequently encountered subset of hypothyroid patients who are refractory to standard thyroid hormone replacement treatment and require unexpectedly high doses of levothyroxine. In addition to clinical situations where hypothyroid patients are non-compliant, or where there is the possibility of excipient-induced disease exacerbation (gluten/celiac disease), therapeutic failure may be due to impaired absorption of the administered drug. The common approach to managing patients with unusual thyroxine needs is to escalate the dose of levothyroxine until targeted TSH levels are achieved...
July 10, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28673589/hepatitis-b-vaccine-non-response-a-predictor-of-latent-autoimmunity
#6
M D Raffaella Mormile
Unresponsiveness to Hepatitis B virus (HBV) vaccine has been associated with interleukins involved with Th1 functioning including Interleukin-8 (IL-18) and Interferon-γ (IFN-γ). IL-18 and IFN-γ have also been implicated in the onset of different types of immune-mediate inflammatory conditions such as Type 1 Diabetes (T1D), Celiac disease (CD), rheumatoid arthritis (RA), obesity and systemic lupus erythematosus (SLE). Taking into account that HBV vaccination is provided in the 1st year of life worldwide, I propose that all babies should be tested for anti-HBs response after completion of the vaccine series...
July 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28673580/the-enteric-toxicity-of-gluten-enhances-graft-versus-host-disease-after-allogeneic-hematopoietic-stem-cell-transplantation
#7
Taylor Neuman, Kevin David, Dennis Cooper, Roger Strair
Pro-inflammatory peptides present in wheat and related grains are associated with celiac disease and non-celiac gluten sensitivity. We hypothesize that these peptides induce enteric responses that may exacerbate the gastrointestinal manifestations of graft-versus-host disease after an allogeneic hematopoietic stem cell transplant. Therefore, we propose that a gluten free diet should be tested as a prophylactic and/or therapeutic intervention against gastrointestinal graft-versus-host disease for patients undergoing an allogeneic hematopoietic stem cell transplant...
July 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28672432/pros-and-cons-while-looking-through-an-asian-window-on-the-rome-iv-criteria-for-irritable-bowel-syndrome-pros
#8
REVIEW
Uday C Ghoshal
A decade after Rome III, in 2016, Rome IV criteria were published. There are major differences between Rome IV and the earlier iteration, some of which are in line with Asian viewpoints. The clinical applicability of the Rome IV criteria of irritable bowel syndrome (IBS) in Asian perspective is reviewed here. Instead of considering functional gastrointestinal disorders (FGIDs) to be largely psychogenic, Rome IV suggested the importance of the gut over brain ("disorders of gut-brain interaction" not "brain-gut interaction")...
July 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28664941/small-bowel-carcinomas-in-celiac-or-crohn-s-disease-distinctive-histophenotypic-molecular-and-histogenetic-patterns
#9
Alessandro Vanoli, Antonio Di Sabatino, Michele Martino, Catherine Klersy, Federica Grillo, Claudia Mescoli, Gabriella Nesi, Umberto Volta, Daniele Fornino, Ombretta Luinetti, Paolo Fociani, Vincenzo Villanacci, Francesco P D'Armiento, Renato Cannizzaro, Giovanni Latella, Carolina Ciacci, Livia Biancone, Marco Paulli, Fausto Sessa, Massimo Rugge, Roberto Fiocca, Gino R Corazza, Enrico Solcia
Non-familial small bowel carcinomas are relatively rare and have a poor prognosis. Two small bowel carcinoma subsets may arise in distinct immune-inflammatory diseases (celiac disease and Crohn's disease) and have been recently suggested to differ in prognosis, celiac disease-associated carcinoma cases showing a better outcome, possibly due to their higher DNA microsatellite instability and tumor-infiltrating T lymphocytes. In this study, we investigated the histological structure (glandular vs diffuse/poorly cohesive, mixed or solid), cell phenotype (intestinal vs gastric/pancreatobiliary duct type) and Wnt signaling activation (β-catenin and/or SOX-9 nuclear expression) in a series of 26 celiac disease-associated small bowel carcinoma, 25 Crohn's disease-associated small bowel carcinoma and 25 sporadic small bowel carcinoma cases, searching for new prognostic parameters...
June 30, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28655974/lymphocytic-duodenitis-or-microscopic-enteritis-and-gluten-related-conditions-what-needs-to-be-explored
#10
REVIEW
Enzo Ierardi, Giuseppe Losurdo, Andrea Iannone, Domenico Piscitelli, Annacinzia Amoruso, Michele Barone, Mariabeatrice Principi, Antonio Pisani, Alfredo Di Leo
Microscopic enteritis (ME) is characterized by abnormal infiltration of intraepithelial lymphocytes in intestinal mucosa. It was described as duodenal lymphocytosis or lymphocytic duodenitis until the dedicated Consensus Conference of 2015. ME represents a common feature of several gluten-mediated and non-gluten related diseases; therefore, it is an umbrella term embracing several conditions. The most frequent causes of ME are gluten-related disorders (celiac disease, non-celiac gluten sensitivity, wheat allergy), Helicobacter pylori infection and drug-related damages...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28638585/clinicopathological-study-of-seronegative-celiac-disease-in-adults-in-pakistan-a-pilot-study
#11
Mohammad Hanif Farina, Rajesh Kumar Mandhwani, Nasir Hassan Luck, Zaigham Abbas, Muhammed Mubarak, S Mudassir Laeeq, Abbas Ali Tasneem
BACKGROUND Celiac disease (CD) is usually missed, if the serology is negative. We aimed to evaluate the clinicopathological characteristics of seronegative CD (SNCD) and its response to gluten-free diet (GFD) in adult patients. METHODS This observational study was carried out at the Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan from 2009 to 2015. All consecutive adult patients (≥17 years) with features of marked villous atrophy (Marsh class≥III) on duodenal biopsy, negative tissue transglutaminase IgA and IgG antibodies (anti-tTg IgA and IgG) and human leukocyte antigen (HLA) DQ2 or DQ8 serotypes were studied...
April 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28632434/screening-for-celiac-disease-by-endomysial-antibodies-in-patients-with-unexplained-hypertransaminasaemia
#12
Mariam Ghozzi, Mohamed Ali Ben Salem, Fatma Mbarki, Ali Jmaa, Azza Baccouch, Nabil Sakly, Elhem Ben Jazia, Ibtissem Ghedira
OBJECTIVE: To do a serological screening for celiac disease in patients with unexplained liver cytolysis. MATERIALS AND METHODS: Fifty-six patients with liver cytolysis without known aetiology were studied. Endomysial antibodies were determined by indirect immunofluorescence on human umbilical cord. Two thousand and five hundred blood donors served as control group. For statistical analysis, we used Chi-square or Fisher's exact test. RESULTS: The frequency of IgA endomysial antibodies in our patients was significantly higher than in the control group (8...
June 20, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28625740/comparative-proteomic-analysis-of-two-transgenic-low-gliadin-wheat-lines-and-non-transgenic-wheat-control
#13
María Dolores García-Molina, Vera Muccilli, Rosaria Saletti, Salvatore Foti, Stefania Masci, Francisco Barro
Gluten proteins are major determinants of the bread making quality of wheat, but also of important wheat-related disorders, including coeliac disease (CD), and allergies. We carried out a proteomic study using the total grain proteins from two low-gliadin wheat lines, obtained by RNAi, and the untransformed wild type as reference. The impact of silencing on both target and on non-target proteins was evaluated. Because of the great protein complexity, we performed separate analyses of four kernel protein fractions: gliadins and glutenin subunits, and metabolic and CM-like proteins, by using a classical 2D electrophoresis gel based approach followed by RP-HPLC/nESI-MS/MS...
June 15, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28625560/small-bowel-ultrasound-beyond-inflammatory-bowel-disease-an-updated-review-of-the-recent-literature
#14
REVIEW
Federica Cavalcoli, Alessandra Zilli, Mirella Fraquelli, Dario Conte, Sara Massironi
The use of bowel ultrasonography (US) for the evaluation of gut diseases has increased in recent years and has been proven to provide a widely available, non-invasive and inexpensive method for the initial work-up and follow-up of different intestinal diseases, limited mostly by technical challenges posed by the patient's anatomy. The present review aims to provide an extensive overview of the main pathologic features at US examination of intestinal diseases other than inflammatory bowel disease, both acute (e...
June 15, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28624578/accuracy-in-diagnosis-of-celiac-disease-without-biopsies-in-clinical-practice
#15
K J Werkstetter, I R Korponay-Szabó, A Popp, V Villanacci, M Salemme, G Heilig, S T Lillevang, M L Mearin, C Ribes-Koninckx, A Thomas, R Troncone, B Filipiak, M Mäki, J Gyimesi, M Najafi, J Dolinšek, S Dydensborg Sander, R Auricchio, A Papadopoulou, A Vécsei, P Szitanyi, E Donat, R Nenna, Ph Alliet, F Penagini, H Garnier-Lengliné, G Castillejo, K Kurppa, R Shamir, A C Hauer, F Smets, S Corujeira, M van Winckel, S Buderus, S Chong, S Husby, S Koletzko, Piotr Socha, Bozena Cukrowska, Hania Szajewska, Jan Wyhowski, Nailah Brown, Gauri Batra, Zrinjka Misak, Sven Seiwerth, Yulia Dmitrieva, Dmitry Abramov, Yvan Vandenplas, Annieta Goossens, Maaike W Schaart, V T H B M Smit, Nicolas Kalach, Pierre Gosset, Judit B Kovács, Anikó Nagy, Ilona Lellei, Rita Kőbányai, Katayoun Khatami, Maryam Monajemzadeh, Konstantina Dimakou, Amalia Patereli, Tine Plato Hansen, Rajko Kavalar, Miguel Bolonio, Hubert Kogler, Gabriele Amann, Roberta Kosova, Mariantonia Maglio, Elke Janssens, Ruth Achten, Pavel Frűhauf, Helena Skálová, Thomas Kirchner, Laura Petrarca, Fabio Massimo Magliocca, Francesc Martínez, Vanesa Morente, Sonja Thanner-Lechner, Manfred Ratschek, Marco Gasparetto, Liz Hook, Danielle Canioni, Catherine Wanty, Anne Mourin, Kaija Laurila, Martine Vornane, Vered Nachmias Friedler, Sara L Morgenstern, Jorge Amil Dias, Fátima Carneiro, Stephanie Van Biervliet, Saskia Vande Velde, Hany Banoub, Steve Sampson, Annette M Müller, Adina Ene, Mandana Rafeey, Iran Amir Taher Eftekhar Sadat
BACKGROUND & AIMS: The guidelines of the European Society of Pediatric Gastroenterology, Hepatology, and Nutrition allow for diagnosis of celiac disease without biopsies in children with symptoms and levels of immunoglobulin A against tissue-transglutaminase (TGA-IgA) 10-fold or more the upper limit of normal (ULN), confirmed by detection of endomysium antibodies (EMA) and positivity for HLA-DQ2/DQ8. We performed a large, international prospective study to validate this approach. METHODS: We collected data from consecutive pediatric patients (18 years or younger) on a gluten-containing diet who tested positive for TGA-IgA from November 2011 through May 2014, seen at 33 pediatric gastroenterology units in 21 countries...
June 15, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28623177/delay-in-diagnosis-of-celiac-disease-in-patients-without-gastrointestinal-complaints
#16
Marco A Paez, Anna Maria Gramelspacher, James Sinacore, Laura Winterfield, Mukund Venu
PURPOSE: The purpose of our study is to investigate the delay in diagnosis of patients with biopsy-proven celiac disease in those who present with gastrointestinal complaints vs non-gastrointestinal complaints at our tertiary care center. Celiac disease is an autoimmune disorder which affects approximately 1% of the population worldwide. Celiac disease can have variable clinical presentations characterized by either predominately gastrointestinal symptoms or may present without any gastrointestinal symptom...
June 13, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28617328/the-long-term-consumption-of-oats-in-celiac-disease-patients-is-safe-a-large-cross-sectional-study
#17
Katri Aaltonen, Pilvi Laurikka, Heini Huhtala, Markku Mäki, Katri Kaukinen, Kalle Kurppa
A strict gluten-free diet (GFD) can be diversified by non-contaminated oats, but there is a shortage of long-term studies concerning its safety. We compared long-term treatment outcomes and factors associated with the introduction of oats between celiac patients on a GFD with or without oats. Eight hundred sixty-nine previously diagnosed celiac patients were interviewed. The validated Gastrointestinal Symptom Rating Scale (GSRS), Psychological General Well-Being (PGWB), and Short-Form 36 Health Survey (SF-36) questionnaires were used to assess symptoms and quality of life, serological tests were performed, and results of histology were confirmed from patient records...
June 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28605936/vascular-disease-and-kidney-stones-abdominal-aortic-calcifications-are-associated-with-low-urine-ph-and-hypocitraturia
#18
Nishant D Patel, Ryan D Ward, Juan Calle, Erick M Remer, Manoj Monga
OBJECTIVE: Vascular calcifications are associated with nephrolithiasis. Although studies have demonstrated correlations with vascular disease and calcium stones in kidney stone formers (KSF), an etiologic link has remained elusive. As a noncontrast CT (NCCT) scan is typically part of a stone evaluation, our objective was to evaluate the association of NCCT-based assessment of abdominal aortic calcifications (AACs) with 24-hour urine parameters and stone composition. MATERIALS AND METHODS: Ninety-seven KSF were included with CT imaging and 24-hour urine studies...
July 7, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28600290/high-throughput-single-cell-analysis-of-b-cell-receptor-usage-among-autoantigen-specific-plasma-cells-in-celiac-disease
#19
Bishnudeo Roy, Ralf S Neumann, Omri Snir, Rasmus Iversen, Geir Kjetil Sandve, Knut E A Lundin, Ludvig M Sollid
Characterization of Ag-specific BCR repertoires is essential for understanding disease mechanisms involving humoral immunity. This is optimally done by interrogation of paired H chain V region (VH) and L chain V region (VL) sequences of individual and Ag-specific B cells. By applying single-cell high-throughput sequencing on gut lesion plasma cells (PCs), we have analyzed the transglutaminase 2 (TG2)-specific VH:VL autoantibody repertoire of celiac disease (CD) patients. Autoantibodies against TG2 are a hallmark of CD, and anti-TG2 IgA-producing gut PCs accumulate in patients upon gluten ingestion...
June 9, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28590771/non-contrast-mr-angiography-using-three-dimensional-balanced-steady-state-free-precession-imaging-for-evaluation-of-stenosis-in-the-celiac-trunk-and-superior-mesenteric-artery-a-preliminary-comparative-study-with-computed-tomography-angiography
#20
Patricia P Cardia, Thiago J Penachim, Adilson Prando, Ulysses S Torres, Giuseppe D'Ippólito
OBJECTIVE: Although non-contrast MR angiography (NC-MRA) is well established for the evaluation of renal artery stenosis, its usefulness in the evaluation of other abdominal aortic branches remains to be studied. This study aimed at evaluating the image quality and diagnostic accuracy of NC-MRA using a three-dimensional balanced steady-state free-precession sequence in identifying stenosis in the celiac trunk (CTR) and superior mesenteric artery (SMA) as compared with CT angiography (CTA) as the reference standard...
July 2017: British Journal of Radiology
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