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https://www.readbyqxmd.com/read/29142467/non-celiac-gluten-sensitivity-all-wheat-attack-is-not-celiac
#1
REVIEW
Samuel O Igbinedion, Junaid Ansari, Anush Vasikaran, Felicity N Gavins, Paul Jordan, Moheb Boktor, Jonathan S Alexander
Currently, 1% of the United States population holds a diagnosis for celiac disease (CD), however, a more recently recognized and possibly related condition, "non-celiac gluten sensitivity" (NCGS) has been suggested to affect up to 6% of the United States public. While reliable clinical tests for CD exist, diagnosing individuals affected by NCGS is still complicated by the lack of reliable biomarkers and reliance upon a broad set of intestinal and extra intestinal symptoms possibly provoked by gluten. NCGS has been proposed to exhibit an innate immune response activated by gluten and several other wheat proteins...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29140275/old-fashioned-vs-ultra-processed-based-current-diets-possible-implication-in-the-increased-susceptibility-to-type-1-diabetes-and-celiac-disease-in-childhood
#2
REVIEW
Sandra V Aguayo-Patrón, Ana M Calderón de la Barca
Ultra-processed foods are ready-to-heat and ready-to-eat products created to replace traditional homemade meals and dishes due to convenience and accessibility. Because of their low-fiber and high-fat and sugar composition, these foodstuffs could induce a negative impact on health. They are partially responsible for obesity and chronic non-transmissible diseases; additionally, they could impact in the prevalence of autoimmune diseases such as type 1 diabetes and celiac disease. The rationale is that the nutritional composition of ultra-processed foodstuffs can induce gut dysbiosis, promoting a pro-inflammatory response and consequently, a "leaky gut"...
November 15, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29131356/gluten-sensitivities-and-the-allergist-threshing-the-grain-from-the-husks
#3
REVIEW
J G Burkhardt, A Chapa-Rodriguez, S L Bahna
"Gluten sensitivity" has become commonplace among the public. Wheat allergy (WA) and celiac disease (CD) are well-defined entities, but are becoming a fraction of individuals following a gluten-free diet. WA has a prevalence of <0.5%. Wheat, specifically its omega-5 gliadin fraction, is the most common allergen implicated in food-dependent, exercise-induced anaphylaxis. CD is a non-IgE hypersensitivity to certain cereal proteins: gluten in wheat, secalin in rye, hordein in barley, and to a lesser extent avenin in oat...
November 13, 2017: Allergy
https://www.readbyqxmd.com/read/29127609/gender-based-differences-in-a-population-based-cohort-with-celiac-disease-more-alike-than-unalike
#4
Claire L Jansson-Knodell, Katherine S King, Joseph J Larson, Carol T Van Dyke, Joseph A Murray, Alberto Rubio-Tapia
BACKGROUND: There is a gap in research focused on gender-based differences in non-referral populations with celiac disease. AIMS: The aim of this study was to estimate those differences in a unique population-based cohort of patients with celiac disease with respect to (1) presenting symptoms, (2) associated autoimmune disorders, and (3) survival. METHODS: Clinical data were systematically abstracted from the electronic medical record of a population-based incident cohort of patients with celiac disease...
November 10, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29127549/preservation-of-the-celiac-branch-of-the-vagal-nerve-for-pylorus-preserving-gastrectomy-is-it-meaningful
#5
Haruna Furukawa, Manabu Ohashi, Michitaka Honda, Koshi Kumagai, Souya Nunobe, Takeshi Sano, Naoki Hiki
BACKGROUND: Preserving the hepatic and pyloric branches of the vagal nerve in laparoscopic pylorus-preserving gastrectomy (LPPG) is considered necessary to maintain the function of the pyloric cuff. However, the clinical benefits of preservation of the celiac branch of the vagal nerve (CBVN) remain unclear. METHODS: Of 391 patients who underwent LPPG for early gastric cancer, 116 patients in whom the CBVN was preserved (CBP group) and 58 patients in whom it was not preserved (non-CBP group) were selected through the propensity score-matching method...
November 10, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29118931/outcome-of-breath-tests-in-adult-patients-with-suspected-small-intestinal-bacterial-overgrowth
#6
Johanna Mattsson, Maria Teresa Minaya, Milka Monegro, Benjamin Lebwohl, Suzanne K Lewis, Peter Hr Green, Reidun Stenberg
Aim: The aim was to investigate breath test outcomes in patients with suspected SIBO and indicative symptoms of SIBO, diagnosed by breath testing. Background: Breath testing is used to detect small intestinal bacterial overgrowth (SIBO) by measuring hydrogen and methane produced by intestinal bacteria. Methods: This retrospective cross sectional study included 311 patients with gastrointestinal symptoms who underwent the breath test for evaluation of SIBO at Celiac Disease Center at Columbia University, New York, in 2014-2015...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29102613/fructan-rather-than-gluten-induces-symptoms-in-patients-with-self-reported-non-celiac-gluten-sensitivity
#7
Gry I Skodje, Vikas K Sarna, Ingunn H Minelle, Kjersti L Rolfsen, Jane G Muir, Peter R Gibson, Marit B Veierød, Christine Henriksen, Knut E A Lundin
BACKGROUND & AIMS: Non-celiac gluten sensitivity is characterized by symptom improvement after gluten withdrawal in absence of celiac disease. The mechanisms of non-celiac gluten sensitivity are unclear, and there are no biomarkers for this disorder. Foods with gluten often contain fructans, a type of fermentable oligo-, di-, monosaccharides and polyols. We aimed to investigate the effect of gluten and fructans separately in individuals with self-reported gluten sensitivity. METHODS: We performed a double-blind crossover challenge of 59 individuals on a self-instituted gluten-free diet, for whom celiac disease had been excluded...
November 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29099018/hla-typing-and-celiac-disease-in-moroccans
#8
Daniela Piancatelli, Imane Ben El Barhdadi, Khadija Oumhani, Pierluigi Sebastiani, Alessia Colanardi, Abdellah Essaid
Genetic and environmental factors are responsible for differences in the prevalence of some diseases across countries. Human leukocyte antigen (HLA) allele frequencies in North African populations show some differences in their distribution compared to Europeans, Mediterraneans, and sub-Saharans, and some specific alleles and haplotypes could be clinically relevant. Celiac disease (CD) has been fast increasing in prevalence in North Africa; but few immunogenetic data are available for this area, in which a high prevalence of the disease has been described...
January 6, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29083383/evaluation-of-multiple-diagnostic-indicators-in-comparison-to-the-intestinal-biopsy-as-the-golden-standard-in-diagnosing-celiac-disease-in-children
#9
Elisabet Hollén, Malin Farnebäck, Tony Forslund, Karl-Eric Magnusson, Tommy Sundqvist, Karin Fälth-Magnusson
Celiac disease (CD) is a chronic small intestinal enteropathy triggered by gluten in genetically predisposed individuals. The susceptibility is strongly associated with certain human leukocyte antigen (HLA)-genes, but efforts are being made in trying to find non-HLA genes that are predictive for the disease. The criteria for diagnosing CD were previously based primarily on histologic evaluation of small intestinal biopsies, but nowadays are often based only on blood tests and symptoms. In this context, we elucidated the accuracy of three diagnostic indicators for CD, alone or in combination...
November 25, 2016: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29082544/echocardiographic-characteristics-in-fontan-patients-before-the-onset-of-protein-losing-enteropathy-or-plastic-bronchitis
#10
Florian Du Bois, Brigitte Stiller, Thomas Borth-Bruhns, Bettina Unseld, Rouven Kubicki, René Hoehn, Katja Reineker, Jochen Grohmann, Thilo Fleck
BACKGROUND: It was this study's objective to evaluate the echocardiographic characteristics and flow patterns in abdominal arteries of Fontan patients before the onset of protein-losing enteropathy (PLE) or plastic bronchitis (PB). DESIGN: In this retrospective cohort investigation, we examined 170 Fontan patients from 32 different centers who had undergone echocardiographic and Doppler ultrasound examinations between June 2006 and May 2013. Follow-up questionnaires were completed by 105 patients a median of 5...
October 29, 2017: Echocardiography
https://www.readbyqxmd.com/read/29079396/celiac-artery-compression-syndrome-evaluated-with-3-d-contrast-enhanced-ultrasonography-a-new-approach
#11
Xian-Ming Wang, Xian-Ping Hua, Guo-Liang Zheng
This study was performed to estimate the value of 3-D contrast-enhanced ultrasonography (3-D-CEUS) in the diagnosis of celiac artery compression syndrome (CACS). Patients suspected of having CACS were assessed with 3-D-CEUS and contrasted with computed tomography angiography. Diagnostic accuracy was evaluated with a receiver operating characteristic curve. Three-dimensional CEUS revealed 19 positive and 9 negative cases. In the negative group, the contrast agent did not change with respiration. In the positive group, the contrast agent exhibited a hook-shaped stenosis on expiration and returned to normal on inspiration...
October 24, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29076383/influenza-and-risk-of-later-celiac-disease-a-cohort-study-of-2-6-million-people
#12
Line Lund Kårhus, Nina Gunnes, Ketil Størdal, Inger Johanne Bakken, German Tapia, Lars C Stene, Siri E Håberg, Karl Mårild
OBJECTIVES: Influenza has been linked to autoimmune conditions, but its relationship to subsequent celiac disease (CD) is unknown. Our primary aim was to determine the risk of CD after influenza. A secondary analysis examined the risk of CD following pandemic influenza vaccination. METHODS: This nationwide register-based cohort study included 2,637,746 Norwegians (born between 1967-2013) followed during 2006-2014 with information on influenza diagnosed in primary or non-primary care, pandemic vaccination (Pandemrix), and subsequent CD...
October 27, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29063352/multivariable-analysis-of-gluten-free-pasta-elaborated-with-non-conventional-flours-based-on-the-phenolic-profile-antioxidant-capacity-and-color
#13
Gustavo A Camelo-Méndez, Pamela C Flores-Silva, Edith Agama-Acevedo, Luis A Bello-Pérez
The phenolic compounds, color and antioxidant capacity of gluten-free pasta prepared with non-conventional flours such as chickpea (CHF), unripe plantain (UPF), white maize (WMF) and blue maize (BMF) were analyzed. Fifteen phenolic compounds (five anthocyanins, five hydroxybenzoic acids, three hydroxycinnamic acids, one hydroxyphenylacetic acid and one flavonol) were identified in pasta prepared with blue maize, and 10 compounds were identified for samples prepared with white maize. The principal component analysis (PCA) led to results describing 98% of the total variance establishing a clear separation for each pasta...
October 23, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29057833/indications-and-use-of-the-gluten-contamination-elimination-diet-for-patients-with-non-responsive-celiac-disease
#14
Maureen M Leonard, Pamela Cureton, Alessio Fasano
For the majority of patients diagnosed with celiac disease, once a gluten-free diet is initiated, symptoms improve within weeks and may completely resolve in months. However, up to 30% of patients may show signs, symptoms or persistent small intestinal damage after one year on a gluten-free diet. These patients require evaluation for other common GI etiologies and assessment of their celiac disease status in order to make a diagnosis and suggest treatment. Here, we propose an approach to evaluating patients with celiac disease with persistent symptoms, persistently elevated serology, and or persistent villous atrophy despite a gluten-free diet...
October 18, 2017: Nutrients
https://www.readbyqxmd.com/read/29037900/autoimmune-comorbidity-in-chronic-spontaneous-urticaria-a-systematic-review
#15
REVIEW
Pavel Kolkhir, Elena Borzova, Clive Grattan, Riccardo Asero, Dmitry Pogorelov, Marcus Maurer
BACKGROUND AND OBJECTIVE: Numerous autoimmune diseases (AIDs) have been linked to chronic spontaneous urticaria (CSU). Here, we provide the first extensive and comprehensive evaluation of the prevalence of AIDs in patients with CSU and vice versa. METHODS: A Pubmed and Google Scholar search was performed to identify studies reporting the prevalence of various AIDs in CSU and vice versa published before April 2017. RESULTS: The prevalence of individual AIDs in CSU is increased (≥1% in most studies vs ≤1% in the general population)...
October 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29018046/co-occurrence-of-type-1-diabetes-and-celiac-disease-autoimmunity
#16
MULTICENTER STUDY
William Hagopian, Hye-Seung Lee, Edwin Liu, Marian Rewers, Jin-Xiong She, Anette-G Ziegler, Åke Lernmark, Jorma Toppari, Stephen S Rich, Jeffrey P Krischer, Henry Erlich, Beena Akolkar, Daniel Agardh
BACKGROUND AND OBJECTIVES: Few birth cohorts have prospectively followed development of type 1 diabetes (T1D) and celiac disease (CD) autoimmunities to determine timing, extent of co-occurrence, and associated genetic and demographic factors. METHODS: In this prospective birth cohort study, 8676 children at high genetic risk of both diseases were enrolled and 5891 analyzed in median follow-up of 66 months. Along with demographic factors and HLA-DR-DQ, genotypes for HLA-DPB1 and 5 non-HLA loci conferring risk of both T1D and CD were analyzed...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/28953524/iron-status-in-pediatric-celiac-disease-a-retrospective-chart-review
#17
Jelena Popov, Mina Baldawi, Lawrence Mbuagbaw, Michelle Gould, Heather Mileski, Herbert Brill, Nikhil Pai
This study assessed the role of serum ferritin as a non-invasive biomarker in the diagnosis and monitoring of pediatric celiac disease. A retrospective chart review was performed on patients < 18 years old at time of diagnosis (n = 193) between 1998-2015. 653 paired values demonstrated a weak negative correlation between serum ferritin and TTG-IgA (r = -0.114; p = 0.004), necessitating further evaluation. A significant relationship was found between reduction of TTG-IgA and increase in serum ferritin after institution of a gluten-free diet (p < 0...
September 26, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28928668/re-challenge-studies-in-non-celiac-gluten-sensitivity-a-systematic-review-and-meta-analysis
#18
Elena Lionetti, Alfredo Pulvirenti, Martina Vallorani, Giulia Catassi, Anil K Verma, Simona Gatti, Carlo Catassi
Background: Non-celiac gluten sensitivity (NCGS) is a clinical entity characterized by intestinal and/or extra-intestinal symptoms related to the ingestion of gluten in individuals that are not affected by either celiac disease (CD) or wheat allergy (WA). Since we do not have specific biomarkers for NCGS, the diagnosis is based on the evidence of a clear relationship between the ingestion of gluten (re-challenge) and clinical symptoms, after a remission during the gluten-free diet (GFD). Several re-challenge studies have been published so far to evaluate the real prevalence of NCGS, reporting conflicting results...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28928632/neurophysiology-of-the-celiac-brain-disentangling-gut-brain-connections
#19
REVIEW
Manuela Pennisi, Alessia Bramanti, Mariagiovanna Cantone, Giovanni Pennisi, Rita Bella, Giuseppe Lanza
Celiac disease (CD) can be considered a complex multi-organ disorder with highly variable extra-intestinal, including neurological, involvement. Cerebellar ataxia, peripheral neuropathy, seizures, headache, cognitive impairment, and neuropsychiatric diseases are complications frequently reported. These manifestations may be present at the onset of the typical disease or become clinically evident during its course. However, CD subjects with subclinical neurological involvement have also been described, as well as patients with clear central and/or peripheral nervous system and intestinal histopathological disease features in the absence of typical CD manifestations...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28921815/low-gluten-non-transgenic-wheat-engineered-with-crispr-cas9
#20
Susana Sánchez-León, Javier Gil-Humanes, Carmen V Ozuna, María J Giménez, Carolina Sousa, Daniel F Voytas, Francisco Barro
Celiac disease is an autoimmune disorder triggered in genetically predisposed individuals by the ingestion of gluten proteins from wheat, barley, and rye. The -gliadin gene family of wheat contains four highly stimulatory peptides, of which the 33-mer is the main immunodominant peptide in celiac patients. We designed two sgRNAs to target a conserved region adjacent to the coding sequence for the 33-mer in the -gliadin genes. Twenty-one mutant lines were generated, all showing strong reduction in -gliadins. Up to 35 different genes were mutated in one of the lines of the 45 different genes identified in the wild type, while immunoreactivity was reduced by 85%...
September 18, 2017: Plant Biotechnology Journal
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