Layde Rosane Paim, Luis Miguel da Silva, Lígia M Antunes-Correa, Vinicius Citelli Ribeiro, Roberto Schreiber, Eduarda O Z Minin, Larissa C M Bueno, Elisangela C P Lopes, Renan Yamaguti, Andréa Coy-Canguçu, Sergio San Juan Dertkigil, Andrei Sposito, Jose Roberto Matos-Souza, Thiago Quinaglia, Tomas G Neilan, Licio A Velloso, Wilson Nadruz, Michael Jerosch-Herold, Otavio R Coelho-Filho
BACKGROUND AND AIMS: Cardiomyocyte hypertrophy and interstitial fibrosis are key components of myocardial remodeling in Heart Failure (HF) with preserved (HFpEF) or reduced ejection fraction (HFrEF). MicroRNAs (miRNAs) are non-coding, evolutionarily conserved RNA molecules that may offer novel insights into myocardial remodeling. This study aimed to characterize miRNA expression in HFpEF (LVEF <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mo>≥</mml:mo></mml:mrow></mml:math> 45%) and HFrEF (LVEF < 45%) and its association with myocardial remodeling...
March 30, 2024: Heliyon