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https://www.readbyqxmd.com/read/28205256/quality-of-life-coping-strategies-social-support-and-self-efficacy-in-women-after-acute-myocardial-infarction-a-mixed-methods-approach
#1
G Fuochi, C Foà
BACKGROUND: Quality of life, coping strategies, social support and self-efficacy are important psychosocial variables strongly affecting the experience of acute myocardial infarction (AMI) in women. AIMS: To gain a more in-depth understanding of how coping strategies, self-efficacy, quality of life and social support shape women's adjustment to AMI. DESIGN: Mixed methods study. Quantitative data were collected through a standardised questionnaire on coping strategies, self-efficacy, quality of life and social support...
February 15, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28198439/miat-is-a-pro-fibrotic-long-non-coding-rna-governing-cardiac-fibrosis-in-post-infarct-myocardium
#2
Xuefeng Qu, Yue Du, You Shu, Ming Gao, Fei Sun, Shenjian Luo, Ti Yang, Linfeng Zhan, Yin Yuan, Wenfeng Chu, Zhenwei Pan, Zhiguo Wang, Baofeng Yang, Yanjie Lu
A long non-coding RNA (lncRNA), named myocardial infarction associated transcript (MIAT), has been documented to confer risk of myocardial infarction (MI). The aim of this study is to elucidate the pathophysiological role of MIAT in regulation of cardiac fibrosis. In a mouse model of MI, we found that MIAT was remarkably up-regulated, which was accompanied by cardiac interstitial fibrosis. MIAT up-regulation in MI was accompanied by deregulation of some fibrosis-related regulators: down-regulation of miR-24 and up-regulation of Furin and TGF-β1...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28182800/cost-of-acute-kidney-injury-in-hospitalized-patients
#3
Samuel A Silver, Jin Long, Yuanchao Zheng, Glenn M Chertow
BACKGROUND: The economic burden of acute kidney injury (AKI) is not well understood. OBJECTIVE: To estimate the effects of AKI on hospitalization costs and length of stay (LOS). DESIGN: Using data from the 2012 National Inpatient Sample, we compared hospitalization costs and LOS with and without AKI. We used a generalized linear model with a gamma distribution and a log link fitted to AKI to adjust for demographics, hospital differences, and comorbidities...
February 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28173757/secondary-prevention-strategies-after-an-acute-st-segment-elevation-myocardial-infarction-in-the-ami-code-era-beyond-myocardial-mechanical-reperfusion
#4
Núria Ribas, Cosme García-García, Oona Meroño, Lluís Recasens, Silvia Pérez-Fernández, Víctor Bazán, Neus Salvatella, Julio Martí-Almor, Jordi Bruguera, Roberto Elosua
BACKGROUND: The AMI code is a regional network enhancing a rapid and widespread access to reperfusion therapy (giving priority to primary angioplasty) in patients with acute ST-segment elevation myocardial infarction (STEMI). We aimed to assess the long-term control of conventional cardiovascular risk factors after a STEMI among patients included in the AMI code registry. DESIGN AND METHODS: Four hundred and fifty-four patients were prospectively included between June-2009 and April-2013...
February 7, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28170314/heart-disease-mortality-in-the-life-span-study-1950-2008
#5
Ikuno Takahashi, Yukiko Shimizu, Eric J Grant, John Cologne, Kotaro Ozasa, Kazunori Kodama
Based on the findings from the Radiation Effects Research Foundation's studies of the cohort of Japanese atomic bomb survivors, it has been reported that total-body irradiation at 0.5-1.0 Gy could be responsible for increased rates of mortality from broad-based categories of cardiovascular disease (CVD), i.e., stroke and heart disease. However, CVD consists of various subtypes that have potentially different radiation dose responses, as well as subtype-specific risks that have not been fully evaluated. Potential problems with changes in the coding rules for the International Classification of Diseases (ICD) and the underlying causes and trends in CVD mortality in Japan also need to be considered...
February 7, 2017: Radiation Research
https://www.readbyqxmd.com/read/28167565/y-rna-fragment-in-extracellular-vesicles-confers-cardioprotection-via-modulation-of-il-10-expression-and-secretion
#6
Linda Cambier, Geoffrey de Couto, Ahmed Ibrahim, Antonio K Echavez, Jackelyn Valle, Weixin Liu, Michelle Kreke, Rachel R Smith, Linda Marbán, Eduardo Marbán
Cardiosphere-derived cells (CDCs) reduce myocardial infarct size via secreted extracellular vesicles (CDC-EVs), including exosomes, which alter macrophage polarization. We questioned whether short non-coding RNA species of unknown function within CDC-EVs contribute to cardioprotection. The most abundant RNA species in CDC-EVs is a Y RNA fragment (EV-YF1); its relative abundance in CDC-EVs correlates with CDC potency in vivo Fluorescently labeled EV-YF1 is actively transferred from CDCs to target macrophages via CDC-EVs...
February 6, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28167232/integrative-network-analysis-reveals-time-dependent-molecular-events-underlying-left-ventricular-remodeling-in-post-myocardial-infarction-patients
#7
Florence Pinet, Marie Cuvelliez, Thomas Kelder, Philippe Amouyel, Marijana Radonjic, Christophe Bauters
To elucidate the time-resolved molecular events underlying the LV remodeling (LVR) process, we developed a large-scale network model that integrates the 24 molecular variables (plasma proteins and non-coding RNAs) collected in the REVE-2 study at four time points (baseline, 1month, 3months and 1year) after MI. The REVE-2 network model was built by extending the set of REVE-2 variables with their mechanistic context based on known molecular interactions (1310 nodes and 8639 edges). Changes in the molecular variables between the group of patients with high LVR (>20%) and low LVR (<20%) were used to identify active network modules within the clusters associated with progression of LVR, enabling assessment of time-resolved molecular changes...
February 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28153684/analysis-of-complication-rates-following-perioperative-transfusion-in-shoulder-arthroplasty
#8
A Jordan Grier, Abiram Bala, Colin T Penrose, Thorsten M Seyler, Michael P Bolognesi, Grant E Garrigues
BACKGROUND: Postoperative anemia requiring a blood transfusion is not uncommon following anatomic total shoulder arthroplasty (TSA) or reverse total shoulder arthroplasty (RTSA). However, the potential complications in patients undergoing transfusion after shoulder arthroplasty remain unclear. The goal of this study was to examine the postoperative outcomes of patients receiving blood transfusions following TSA and RTSA. METHODS: Using the Medicare Standard Analytic Files database, we identified all patients undergoing TSA or RTSA between 2005 and 2010...
January 30, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28151544/relationship-between-past-myocardial-infarction-periodontal-disease-and-porphyromonas-gingivalis-serum-antibodies-a-case-control-study
#9
Radosław P Łysek, Krystyna Szafraniec, Maciej Polak, Piotr Jankowski, Agnieszka Micek, Renata Wolfshaut-Wolak, Danuta Czarnecka, Jan Potempa, Andrzej Pająk
BACKGROUND: The relationship between chronic periodontitis (CP) and increased risk for cardiovascular disease (CVD) is known but quantitative assessments and mechanisms are not fully understood. The aim of this study was to assess the relationship between past myocardial infarction (MI) and the severity of CP, and the level of serum antibody titer against Porphyromonas gingivalis gingipains. METHODS: The study sample consisted of 97 patients after MI and 113 high risk controls with no history of coronary heart disease (CHD) matched with age, sex and place of residence (urban vs...
2, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28138556/myocardial-micrornas-associated-with-reverse-remodeling-in-human-heart-failure
#10
Carmen C Sucharov, David P Kao, J David Port, Anis Karimpour-Fard, Robert A Quaife, Wayne Minobe, Karin Nunley, Brian D Lowes, Edward M Gilbert, Michael R Bristow
BACKGROUND: In dilated cardiomyopathies (DCMs) changes in expression of protein-coding genes are associated with reverse remodeling, and these changes can be regulated by microRNAs (miRs). We tested the general hypothesis that dynamic changes in myocardial miR expression are predictive of β-blocker-associated reverse remodeling. METHODS: Forty-three idiopathic DCM patients (mean left ventricular ejection fraction 0.24 ± 0.09) were treated with β-blockers. Serial ventriculography and endomyocardial biopsies were performed at baseline, and after 3 and 12 months of treatment...
January 26, 2017: JCI Insight
https://www.readbyqxmd.com/read/28115490/the-long-noncoding-rna-landscape-of-the-ischemic-human-left-ventricle
#11
Louis A Saddic, Martin I Sigurdsson, Tzuu-Wang Chang, Erica Mazaika, Mahyar Heydarpour, Stanton K Shernan, Christine E Seidman, Jon G Seidman, Sary F Aranki, Simon C Body, Jochen D Muehlschlegel
BACKGROUND: The discovery of functional classes of long noncoding RNAs (lncRNAs) has expanded our understanding of the variety of RNA species that exist in cells. In the heart, lncRNAs have been implicated in the regulation of development, ischemic and dilated cardiomyopathy, and myocardial infarction. Nevertheless, there is a limited description of expression profiles for these transcripts in human subjects. METHODS AND RESULTS: We obtained left ventricular tissue from human patients undergoing cardiac surgery and used RNA sequencing to describe an lncRNA profile...
January 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28107200/variants-in-anril-gene-correlated-with-its-expression-contribute-to-myocardial-infarction-risk
#12
Jie Cheng, Meng-Yun Cai, Yu-Ning Chen, Zhi-Cheng Li, Sai-Sai Tang, Xi-Li Yang, Can Chen, Xinguang Liu, Xing-Dong Xiong
ANRIL (antisense non-coding RNA in the INK4 locus), located at the 9p21.3 locus, has been known to be closely associated with the risk of coronary artery disease (CAD). To date, studies of the 9p21.3 variants on CAD risk mainly focus on the non-coding region of ANRIL. However, the biological significance of the variants on ANRIL promoter and exons is still unknown. Here we investigate whether the variants on ANRIL promoter and exons have an effect on myocardial infarction (MI) risk, and further analyze the association of these variants with the expression of ANRIL transcript...
January 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28104481/identification-of-the-potentially-arrhythmogenic-substrate-in-the-acute-phase-of-st-segment-elevation-myocardial-infarction
#13
Diego Penela, Juan Acosta, David Andreu, Jose T Ortiz, Xavier Bosch, Rosario J Perea, Teresa M de Caralt, Juan Fernández-Armenta, David Soto, Susana Prat, Roger Borràs, Lluis Mont, Vanessa Hervas, Manuel Morales, Wladimiro Jiménez, Aurea Mira, Jim Donnelly, Okan Ekinci, Luis Lasalvia, Antonio Berruezo
BACKGROUND: Predicting sudden cardiac death risk in the first months after ST-segment elevation myocardial infarction (STEMI) remains challenging. OBJECTIVE: The purpose of this study was to investigate the ability of late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) to identify the potentially arrhythmogenic substrate and its temporal evolution after STEMI. METHODS: One hundred consecutive patients with a first STEMI were included...
January 17, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28101856/relationship-of-long-term-prognosis-to-mmp-and-timp-polymorphisms-in-patients-after-st-elevation-myocardial-infarction
#14
Monika Pavkova Goldbergova, Jiri Jarkovsky, Jolana Lipkova, Simona Littnerova, Martin Poloczek, Jindrich Spinar, Lenka Kubkova, Krystyna Kluz, Petr Kala, Jan Manousek, Anna Vasku, Jiri Parenica
The influence of polymorphisms in the large group of MMP and TIMP genes on clinical outcomes in patients after ST elevation myocardial infarction (STEMI) treated with primary PCI was analysed. In total, 550 consecutive Caucasian patients with STEMI were included in the present study, with a median of 32 months. We analysed 19 polymorphisms in the genes coding MMP and TIMP genes. The MMP-1 -519A/G and -422A/T polymorphisms are associated with combined endpoint after myocardial infarction. The hazard ratio for AT variant of MMP-1 -422A/T was 1...
January 18, 2017: Journal of Applied Genetics
https://www.readbyqxmd.com/read/28099117/casz1-loss-of-function-mutation-contributes-to-familial-dilated-cardiomyopathy
#15
Xing-Biao Qiu, Xin-Kai Qu, Ruo-Gu Li, Hua Liu, Ying-Jia Xu, Min Zhang, Hong-Yu Shi, Xu-Min Hou, Xu Liu, Fang Yuan, Yu-Min Sun, Jun Wang, Ri-Tai Huang, Song Xue, Yi-Qing Yang
BACKGROUND: The zinc finger transcription factor CASZ1 plays a key role in cardiac development and postnatal adaptation, and in mice, deletion of the CASZ1 gene leads to dilated cardiomyopathy (DCM). However, in humans whether genetically defective CASZ1 contributes to DCM remains unclear. METHODS: The coding exons and splicing junction sites of the CASZ1 gene were sequenced in 138 unrelated patients with idiopathic DCM. The available family members of the index patient harboring an identified CASZ1 mutation and 200 unrelated, ethnically matched healthy individuals used as controls were genotyped for CASZ1...
January 18, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28097322/management-and-outcomes-of-st-segment-elevation-myocardial-infarction-in-us-renal-transplant-recipients
#16
Tanush Gupta, Dhaval Kolte, Sahil Khera, Kashish Goel, Wilbert S Aronow, Howard A Cooper, Diwakar Jain, Charanjit S Rihal, Gregg C Fonarow, Julio A Panza, Deepak L Bhatt
Importance: Renal transplantation is associated with reduction in the risk for myocardial infarction (MI) in patients with chronic kidney disease requiring long-term dialysis (stage 5D CKD). Whether outcomes of MI differ among renal transplant recipients vs patients with stage 5D CKD or those without CKD has not been well examined. Objectives: To compare in-hospital reperfusion rates and outcomes of ST-segment elevation MI (STEMI) in renal transplant recipients vs the stage 5D CKD group or the non-CKD group...
January 11, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28092254/-what-do-adults-die-in-mexico-impact-on-the-economic-and-social-development-of-the-nation-the-global-burden-of-cardiovascular-disease
#17
Martín Rosas-Peralta, Efraín Arizmendi-Uribe, Gabriela Borrayo-Sánchez
Noncommunicable diseases have been established as a clear threat, not only to human health but also to the development and economic growth. Claiming 63% of all deaths, these diseases are currently the main murderer worldwide. The increase in the prevalence and importance of noncommunicable diseases specifically of cardiovascular risk factors such as hypertension, diabetes, dyslipidemia and obesity is the result of a complex interplay between health, economic growth and development, which is strongly associated with universal trends such as the aging of the world population, rapid unplanned urbanization, and the globalization of unhealthy lifestyles...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28065772/multimorbidity-in-middle-aged-adults-with-cerebral-palsy
#18
Nicole Cremer, Edward A Hurvitz, Mark D Peterson
BACKGROUND: Individuals with cerebral palsy have less lean body mass, greater relative adiposity, and lower fitness and physical activity participation; and yet, the prevalence of age-related multimorbidity in this population has yet to be established. PURPOSE: To examine the prevalence of lifestyle-related chronic conditions and multimorbidity in a sample of middle-aged adults with cerebral palsy. METHODS: A clinic-based sample of middle-aged adults with cerebral palsy was examined using Electronic Medical Records Search Engine (EMERSE) software...
January 5, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28065768/ventricular-septal-defect-complicating-st-elevation-myocardial-infarctions-a-call-for-action
#19
Vikas Singh, Alex P Rodriguez, Parth Bhatt, Carlos E Alfonso, Rahul Sakhuja, Igor F Palacios, Ignacio Inglessis-Azuaje, Mauricio G Cohen, Sammy Elmariah, William W O'Neill
BACKGROUND: Ventricular septal defect is a lethal complication after an acute myocardial infarction which have become infrequent with the advent of reperfusion strategies however; they remain a major contributor to mortality. METHODS: We identified patients using the ICD-9CM procedure codes from the Nationwide Inpatient Sample between the years 2001 and 2013. A multivariate hierarchical logistic regression model was used to identify significant predictors of in-hospital mortality...
January 5, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28063854/hospital-admissions-for-chest-pain-associated-with-cocaine-use-in-the-united-states
#20
Vikas Singh, Alex P Rodriguez, Badal Thakkar, Ghamshyambhai R Savani, Nileshkumar J Patel, Apurva O Badheka, Mauricio G Cohen, Carlos E Alfonso, Raul D Mitrani, Juan Viles-Gonzalez, Jeffrey J Goldberger
BACKGROUND: The outcomes related to chest pain associated with cocaine use and its burden on healthcare system are not well studied. METHODS: Data were collected from the Nationwide Inpatient Sample (2001 - 2012). Subjects were identified by using the ICD-9-CM codes. Primary outcome was a composite of mortality, myocardial infarction, stroke and cardiac arrest. RESULTS: We identified 363,143 admissions for cocaine induced chest pain. Mean age was 44...
January 4, 2017: American Journal of Medicine
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