Yi Hu, Huaming Cao, Jie Sheng, Yizhuo Sun, Yuping Zhu, Qin Lin, Na Yi, Siyu He, Luying Peng, Li Li
Pathological myocardial hypertrophy is a common early clinical manifestation of heart failure, with non-coding RNAs exerting regulatory influence. However, the molecular function of circular RNAs (circRNAs) in the progression from cardiac hypertrophy to heart failure remains unclear. To uncover functional circRNAs and identify the core circRNA signaling pathway in heart failure, we construct a global triple network (microRNA, circRNA, and mRNA) based on the competitive endogenous RNA (ceRNA) theory. We observe that circRNA CHRC, within the ceRNA network, is down-regulated in both transverse aortic constriction (TAC) mice and Ang-II-treated primary mouse cardiomyocytes...
April 2, 2024: Journal of Genetics and Genomics