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https://www.readbyqxmd.com/read/27899496/hormonal-contraception-and-risk-of-thromboembolism-in-women-with-diabetes
#1
Sarah H O'Brien, Terah Koch, Sara K Vesely, Eleanor Bimla Schwarz
OBJECTIVE: To investigate safety of hormonal contraception with regard to thromboembolic events in women with type 1 or 2 diabetes. RESEARCH DESIGN AND METHODS: We used data from 2002-2011 in Clinformatics Data Mart to identify women in the U.S., 14-44 years of age, with an ICD-9-CM code for diabetes and a prescription for a diabetic medication or device. We examined contraceptive claims and compared time to thromboembolism (venous thrombosis, stroke, or myocardial infarction) among women with diabetes dispensed hormonal contraception using a modification of Cox regression to control for age, smoking, obesity, hypertension, hyperlipidemia, diabetic complications, and history of cancer; we excluded data for 3 months after women gave birth...
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27896982/predictive-modeling-of-hospital-readmission-rates-using-electronic-medical-record-wide-machine-learning-a-case-study-using-mount-sinai-heart-failure-cohort
#2
Khader Shameer, Kipp W Johnson, Alexandre Yahi, Riccardo Miotto, L I Li, Doran Ricks, Jebakumar Jebakaran, Patricia Kovatch, Partho P Sengupta, Sengupta Gelijns, Alan Moskovitz, Bruce Darrow, David L David, Andrew Kasarskis, Nicholas P Tatonetti, Sean Pinney, Joel T Dudley
Reduction of preventable hospital readmissions that result from chronic or acute conditions like stroke, heart failure, myocardial infarction and pneumonia remains a significant challenge for improving the outcomes and decreasing the cost of healthcare delivery in the United States. Patient readmission rates are relatively high for conditions like heart failure (HF) despite the implementation of high-quality healthcare delivery operation guidelines created by regulatory authorities. Multiple predictive models are currently available to evaluate potential 30-day readmission rates of patients...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27894414/anril-rs2383207-polymorphism-and-coronary-artery-disease-cad-risk-a-meta-analysis-with-observational-studies
#3
P Wang, P Dong, X Yang
Some studies investigated the association of antisense non-coding RNA in the INK4 locus (ANRIL) rs2383207 polymorphism with coronary artery disease (CAD) risk. However, the result was still inconsistent. The aim of this study was to investigate whether there is an association between the ANRIL rs2383207 polymorphism and CAD risk. We carried out a PubMed (Medline), EMBASE database search covering all published articles. The strength of association between ANRIL rs2383207 polymorphism and CAD risk was assessed by calculating OR with 95% CI...
October 31, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27885709/the-median-hazard-ratio-a-useful-measure-of-variance-and-general-contextual-effects-in-multilevel-survival-analysis
#4
Peter C Austin, Philippe Wagner, Juan Merlo
Multilevel data occurs frequently in many research areas like health services research and epidemiology. A suitable way to analyze such data is through the use of multilevel regression models (MLRM). MLRM incorporate cluster-specific random effects which allow one to partition the total individual variance into between-cluster variation and between-individual variation. Statistically, MLRM account for the dependency of the data within clusters and provide correct estimates of uncertainty around regression coefficients...
November 25, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27878945/regulatory-non-coding-rnas-in-acute-myocardial-infarction
#5
REVIEW
Yuan Guo, Fei Luo, Qiong Liu, Danyan Xu
Acute myocardial infarction (AMI) is one of the most common cardiovascular diseases that leads to high mortality and morbidity globally. Various therapeutic targets for AMI have been investigated in recent years, including the non-coding RNAs (ncRNAs). NcRNAs, a class of RNA molecules that typically do not code proteins, are divided into several subgroups. Among them, microRNAs (miRNAs) are widely studied for their modulation of several pathological aspects of AMI, including cardiomyocyte apoptosis, inflammation, angiogenesis and fibrosis...
November 23, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27874977/relationship-between-age-and-trajectories-of-rehospitalization-risk-in-older-adults
#6
Kumar Dharmarajan, Angela Hsieh, Rachel P Dreyer, Jack Welsh, Li Qin, Harlan M Krumholz
OBJECTIVES: To characterize the magnitude and duration of risk of rehospitalization according to age after hospitalization for heart failure (HF), acute myocardial infarction (AMI), or pneumonia. DESIGN: Retrospective cohort study. SETTING: U.S. hospitals (n = 4,767). PARTICIPANTS: All Medicare fee-for-service beneficiaries aged 65 and older surviving hospitalization for HF, AMI, or pneumonia between October 2012 and December 2013...
November 22, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27874027/circulating-long-non-coding-rnas-as-biomarkers-of-left-ventricular-diastolic-function-and-remodelling-in-patients-with-well-controlled-type-2-diabetes
#7
D de Gonzalo-Calvo, F Kenneweg, C Bang, R Toro, R W van der Meer, L J Rijzewijk, J W Smit, H J Lamb, V Llorente-Cortes, T Thum
Contractile dysfunction is underdiagnosed in early stages of diabetic cardiomyopathy. We evaluated the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers of subclinical cardiac abnormalities in type 2 diabetes. Forty-eight men with well-controlled type 2 diabetes and 12 healthy age-matched volunteers were enrolled in the study. Left ventricular (LV) parameters were measured by magnetic resonance imaging. A panel of lncRNAs was quantified in serum by RT-qPCR. No differences in expression levels of lncRNAs were observed between type 2 diabetes patients and healthy volunteers...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872154/genetic-determinants-of-myocardial-dysfunction
#8
REVIEW
Xianchi Li, Peiying Zhang
Heart failure (HF) is a major killer with high morbidity and mortality and nearly 37.7 million people are affected by HF globally, making this a global epidemic. HF is a complex pathophysiological syndrome in which the mechanical function of heart for pumping blood is compromised. Cardiac structural and functional abnormalities culminate in decreased cardiac output along with increased intracardiac pressures under resting or stress conditions, leading to HF. Besides the acquired risk factors, the independent role of hereditary and genetic factors in the development, progression and prognosis of HF remains to be established...
November 21, 2016: Journal of Medical Genetics
https://www.readbyqxmd.com/read/27864384/reconciling-systems-for-acute-myocardial-infarction-definition-and-coding-classification
#9
EDITORIAL
L Kristin Newby
No abstract text is available yet for this article.
November 18, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27864249/positive-predictive-value-of-cardiovascular-diagnoses-in-the-danish-national-patient-registry-a-validation-study
#10
Jens Sundbøll, Kasper Adelborg, Troels Munch, Trine Frøslev, Henrik Toft Sørensen, Hans Erik Bøtker, Morten Schmidt
OBJECTIVE: The majority of cardiovascular diagnoses in the Danish National Patient Registry (DNPR) remain to be validated despite extensive use in epidemiological research. We therefore examined the positive predictive value (PPV) of cardiovascular diagnoses in the DNPR. DESIGN: Population-based validation study. SETTING: 1 university hospital and 2 regional hospitals in the Central Denmark Region, 2010-2012. PARTICIPANTS: For each cardiovascular diagnosis, up to 100 patients from participating hospitals were randomly sampled during the study period using the DNPR...
November 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27862640/long-non-coding-rna-malat1-functions-as-a-mediator-in-cardioprotective-effects-of-fentanyl-in-myocardial-ischemia-reperfusion-injury
#11
Zhi-Hui Zhao, Wei Hao, Qing-Tao Meng, Xiao-Bing Du, Shao-Qing Lei, Zhong-Yuan Xia
Long non-coding (lncRNA) MALAT1 can be increased by hypoxia or ischemic limbs. Also downregulation of MALAT1 contributes to reduction of cardiomyocyte apoptosis. However, the functional involvement of MALAT1 in myocardial ischemia-reperfusion (I/R) injury has not been defined. This study investigated the functional involvement of lncRNA-MALAT1 in cardioprotective effects of fentanyl. HL-1, a cardiac muscle cell line from the AT-1 mouse atrial cardiomyocyte tumor lineage, was pre-treated with fentanyl and generated cell model of hypoxia-reoxygenation (H/R)...
November 9, 2016: Cell Biology International
https://www.readbyqxmd.com/read/27848189/the-impact-of-disability-and-social-determinants-of-health-on-condition-specific-readmissions-beyond-medicare-risk-adjustments-a-cohort-study
#12
Jennifer Meddings, Heidi Reichert, Shawna N Smith, Theodore J Iwashyna, Kenneth M Langa, Timothy P Hofer, Laurence F McMahon
BACKGROUND: Readmission rates after pneumonia, heart failure, and acute myocardial infarction hospitalizations are risk-adjusted for age, gender, and medical comorbidities and used to penalize hospitals. OBJECTIVE: To assess the impact of disability and social determinants of health on condition-specific readmissions beyond current risk adjustment. DESIGN, SETTING, AND PARTICIPANTS: Retrospective cohort study of Medicare patients using 1) linked Health and Retirement Study-Medicare claims data (HRS-CMS) and 2) Healthcare Cost and Utilization Project State Inpatient Databases (Florida, Washington) linked with ZIP Code-level measures from the Census American Community Survey (ACS-HCUP)...
November 15, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27829552/micrornas-regulate-mitochondrial-apoptotic-pathway-in-myocardial-ischemia-reperfusion-injury
#13
REVIEW
Pouran Makhdoumi, Ali Roohbakhsh, Gholamreza Karimi
MicroRNAs (miRNAs) are small non-coding RNAs that act as post-transcriptional gene regulators. They are involved in the pathogenesis of different disorders including heart diseases. MiRNAs contribute to ischemia/reperfusion injury (I/RI) by altering numerous key signaling elements. Together with alterations in the various potential signaling pathways, modification in miRNA expression has been suggested as a part of the response network following ischemia/reperfusion (I/R). In addition, cardiac mitochondrial homeostasis is closely associated with cardiac function and impairment of mitochondrial activity occurred after ischemia/reperfusion injury...
November 6, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27811209/discordance-between-icd-coded-myocardial-infarction-and-diagnosis-according-to-the-universal-definition-of-myocardial-infarction
#14
Jorge Díaz-Garzón, Yader Sandoval, Stephen W Smith, Sara Love, Karen Schulz, Sarah E Thordsen, Benjamin K Johnson, Brian Driver, Katherine Jacoby, Michelle D Carlson, Kenneth W Dodd, Johanna Moore, Nathaniel L Scott, Charles A Bruen, Ryan Hatch, Fred S Apple
BACKGROUND: International Classification of Diseases (ICD) coding is the standard diagnostic tool for healthcare management. At present, type 2 myocardial infarction (T2MI) classification by the Universal Definition of Myocardial Infarction (MI) remains ignored in the ICD system. We determined the concordance for the diagnosis of MI using ICD-9 coding vs the Universal Definition. METHODS: Cardiac troponin I (cTnI) was measured by both contemporary (cTnI) and high-sensitivity (hs-cTnI) assays in 1927 consecutive emergency department (ED) patients [Use of TROPonin In Acute coronary syndromes (UTROPIA) cohort] who had cTnI ordered on clinical indication...
November 3, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27797128/long-non-coding-rna-miat-knockdown-promotes-osteogenic-differentiation-of-human-adipose-derived-stem-cells
#15
Chanyuan Jin, Yunfei Zheng, Yiping Huang, Yunsong Liu, Lingfei Jia, Yongsheng Zhou
Recently, long non-coding RNAs (lncRNAs) have emerged as critical players in gene regulation for multiple biological processes. However, their roles and functions in human adipose-derived stem cells (hASCs) differentiation remain unclear. In the present study, we investigated the role of lncRNA myocardial infarction-associated transcript (MIAT) in the osteogenic differentiation of hASCs. We found that the expression of MIAT was downregulated in a time-dependent manner during hASCs osteoinduction. MIAT knockdown promoted osteogenic differentiation of hASCs both in vitro and in vivo...
October 31, 2016: Cell Biology International
https://www.readbyqxmd.com/read/27755259/influence-of-depression-on-utilization-of-cardiac-rehabilitation-postmyocardial-infarction-a-study-of-158-991-medicare-beneficiaries
#16
Melissa D Zullo, Emily C Gathright, Mary A Dolansky, Richard A Josephson, Vinay K Cheruvu, Joel W Hughes
PURPOSE: On the basis of several small studies, depression is often considered a barrier to cardiac rehabilitation (CR) enrollment and program completion. The purpose of this research was to examine the association between depression diagnosis and participation in CR in a large sample of Medicare beneficiaries with recent myocardial infarction (MI). METHODS: This was a retrospective study of Medicare beneficiaries with an MI during 2008 (N = 158 991). CR enrollment was determined by the Carrier and Outpatient files using the Healthcare Common Procedure Coding System #93797 or #93798...
October 14, 2016: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/27751900/trends-in-incidence-of-hospitalized-acute-myocardial-infarction-in-the-cardiovascular-research-network-cvrn
#17
Kristi Reynolds, Alan S Go, Thomas K Leong, Denise M Boudreau, Andrea E Cassidy-Bushrow, Stephen P Fortmann, Robert J Goldberg, Jerry H Gurwitz, David J Magid, Karen L Margolis, Catherine J McNeal, Katherine M Newton, Rachel Novotny, Charles P Quesenberry, Wayne D Rosamond, David H Smith, Jeffrey J VanWormer, Suma Vupputuri, Stephen C Waring, Marc S Williams, Stephen Sidney
BACKGROUND: Monitoring trends in cardiovascular events can provide key insights into the effectiveness of prevention efforts. Leveraging data from electronic health records provides a unique opportunity to examine contemporary, community-based trends in acute myocardial infarction hospitalizations. METHODS: We examined trends in hospitalized acute myocardial infarction incidence among adults aged ≥25 years in 13 US health plans in the Cardiovascular Research Network...
October 14, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27747683/difficulty-using-smart-pump-logs-to-recreate-a-patient-safety-event-case-study-and-considerations-for-pump-enhancements
#18
Andrew A M Ibey, Derek Andrews, Barb Ferreira
The authors present a case in which a physical anomaly with an infusion pump resulted in an unforeseen fault that the nurse's attempts to resolve unknowingly exacerbated. This case study presents the first report in the literature to detail the difficulty in recreating a patient safety event using smart pump logs, support server continuous quality improvement (CQI) data, and the drug order entry system to elucidate the clinical scenario. A 75-year-old male patient presented to a major teaching hospital and was admitted to the intensive care unit (ICU) with a massive gastrointestinal bleed and myocardial infarction, then stabilized...
December 2016: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27742512/variability-in-standard-outcomes-of-posterior-lumbar-fusion-determined-by-national-databases
#19
Jacob R Joseph, Brandon W Smith, Paul Park
OBJECTIVE: National databases are used with increasing frequency in spine surgery literature to evaluate patient outcomes. The differences between individual databases in relationship to outcomes of lumbar fusion are not known. We evaluated the variability in standard outcomes of posterior lumbar fusion between the University HealthSystem Consortium (UHC) database and the Healthcare Cost and Utilization Project National Inpatient Sample (NIS). METHODS: NIS and UHC databases were queried for all posterior lumbar fusions (ICD-9 81...
October 11, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27703034/clinical-impact-of-subsequent-depression-in-patients-with-a-new-diagnosis-of-stable-angina-a-population-based-study
#20
Natalie Szpakowski, Maria C Bennell, Feng Qiu, Dennis T Ko, Jack V Tu, Paul Kurdyak, Harindra C Wijeysundera
BACKGROUND: Depression is prevalent among patients with myocardial infarction and is associated with a worse prognosis. However, little is known about its importance in patients with chronic stable angina. We conducted a retrospective population-based cohort study to determine the occurrence and predictors of developing depression in patients with a new diagnosis of chronic stable angina. In addition, we sought to understand its impact on subsequent clinical outcomes. METHODS AND RESULTS: Our cohort included patients in Ontario, Canada, with stable angina based on obstructive coronary artery disease found on angiogram...
October 4, 2016: Circulation. Cardiovascular Quality and Outcomes
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