Verena B Eisenbeis, Danye Qiu, Oliver Gorka, Lisa Strotmann, Guizhen Liu, Isabel Prucker, Xue Bessie Su, Miranda S C Wilson, Kevin Ritter, Christoph Loenarz, Olaf Groß, Adolfo Saiardi, Henning J Jessen
Inositol pyrophosphates (PP-InsPs) are energetic signaling molecules with important functions in mammals. As their biosynthesis depends on ATP concentration, PP-InsPs are tightly connected to cellular energy homeostasis. Consequently, an increasing number of studies involve PP-InsPs in metabolic disorders, such as type 2 diabetes, aspects of tumorigenesis, and hyperphosphatemia. Research conducted in yeast suggests that the PP-InsP pathway is activated in response to reactive oxygen species (ROS). However, the precise modulation of PP-InsPs during cellular ROS signaling is unknown...
August 22, 2023: Proceedings of the National Academy of Sciences of the United States of America