Simone Gattarello, Fabio Lombardo, Federica Romitti, Rosanna D'Albo, Mara Velati, Isabella Fratti, Tommaso Pozzi, Rosmery Nicolardi, Antonio Fioccola, Mattia Busana, Francesca Collino, Peter Herrmann, Luigi Camporota, Michael Quintel, Onnen Moerer, Leif Saager, Konrad Meissner, Luciano Gattinoni
BACKGROUND: The individual components of mechanical ventilation may have distinct effects on kidney perfusion and on the risk of developing acute kidney injury; we aimed to explore ventilatory predictors of acute kidney failure and the hemodynamic changes consequent to experimental high-power mechanical ventilation. METHODS: Secondary analysis of two animal studies focused on the outcomes of different mechanical power settings, including 78 pigs mechanically ventilated with high mechanical power for 48 h...
March 21, 2024: Intensive Care Medicine Experimental