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https://www.readbyqxmd.com/read/29922438/the-effect-of-anti-inflammatory-and-antifibrotic-agents-on-fibroblasts-obtained-from-arthrofibrotic-tissue-an-in-vitro-and-in-vivo-study
#1
X Tang, S Teng, M Petri, C Krettek, C Liu, M Jagodzinski
Objectives: The aims of this study were to determine whether the administration of anti-inflammatory and antifibrotic agents affect the proliferation, viability, and expression of markers involved in the fibrotic development of the fibroblasts obtained from arthrofibrotic tissue in vitro , and to evaluate the effect of the agents on arthrofibrosis prevention in vivo . Methods: Dexamethasone, diclofenac, and decorin, in different concentrations, were employed to treat fibroblasts from arthrofibrotic tissue (AFib)...
March 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29887481/new-onset-atrial-fibrillation-in-critically-ill-patients-and-its-association-with-mortality-a-report-from-the-frog-icu-study
#2
Mattia Arrigo, Shiro Ishihara, Elodie Feliot, Alain Rudiger, Nicolas Deye, Alain Cariou, Bertrand Guidet, Samir Jaber, Marc Leone, Matthieu Resche-Rigon, Antoine Vieillard Baron, Matthieu Legrand, Etienne Gayat, Alexandre Mebazaa
BACKGROUND: Atrial fibrillation (AFib) is associated with adverse outcome in critical illness, but whether this effect is independent from other risk factors remains uncertain. New-onset AFib during critical illness may be independently associated with increased in-hospital and long-term risk of death. METHODS: FROG-ICU was a prospective, observational, multi-centre cohort study designed to investigate the outcome of critically ill patients. Inclusion criteria were invasive mechanical ventilation and/or treatment with a positive inotropic agent for >24 h...
September 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29734438/cryoelectrolysis-for-treatment-of-atrial-fibrillation-a-first-order-feasibility-study
#3
M Hjouj, H Krishnan, B Rubinsky
  BACKGROUND: Catheter based treatment of atrial fibrillation (AFib) involves ablation of groups of cells near the pulmonary vein. OBJECTIVE: The goal of this study was to evaluate the technological feasability of a new technology for catheter-based ablation for treatment of AFib that combines freezing with electrolysis. MATERIALS AND METHODS: The study was performed on a pH dye stained gel phantom of the pulmonary vein. Freezing was induced with a cryosurgical probe inserted in the vein and electrolysis was delivered through the probe with a DC power supply...
November 2017: Cryo Letters
https://www.readbyqxmd.com/read/29657903/obstructive-sleep-apnea-as-a-risk-factor-for-atrial-fibrillation-a-meta-analysis
#4
Irini Youssef, Haroon Kamran, Mena Yacoub, Nirav Patel, Clive Goulbourne, Shweta Kumar, Jesse Kane, Haley Hoffner, Moro Salifu, Samy I McFarlane
Objectives: To conducted a meta-analysis assessing the relationship between Obstructive Sleep Apnea (OSA) and the risk of Atrial Fibrillation (AF). Methods: We searched PUBMED, Medline, and Cochrane Library using the keywords "atrial fibrillation", "obstructive sleep apnea" and "sleep disordered breathing (SDB)". All subjects included had established diagnosis of OSA/SDB. We then compared the occurrence of AF versus no AF. Analysis done with Comprehensive Meta-Analysis package V3 (Biostat, USA)...
2018: Journal of Sleep Disorders & Therapy
https://www.readbyqxmd.com/read/29549073/evaluating-the-usability-and-usefulness-of-a-mobile-app-for-atrial-fibrillation-using-qualitative-methods-exploratory-pilot-study
#5
Jaclyn Hirschey, Sunetra Bane, Moussa Mansour, Jodi Sperber, Stephen Agboola, Joseph Kvedar, Kamal Jethwani
BACKGROUND: Atrial fibrillation (AFib) is the most common form of heart arrhythmia and a potent risk factor for stroke. Nonvitamin K antagonist oral anticoagulants (NOACs) are routinely prescribed to manage AFib stroke risk; however, nonadherence to treatment is a concern. Additional tools that support self-care and medication adherence may benefit patients with AFib. OBJECTIVE: The aim of this study was to evaluate the perceived usability and usefulness of a mobile app designed to support self-care and treatment adherence for AFib patients who are prescribed NOACs...
March 15, 2018: JMIR Human Factors
https://www.readbyqxmd.com/read/29350386/comparison-of-clinical-characteristics-of-real-life-atrial-fibrillation-patients-treated-with-vitamin-k-antagonists-dabigatran-and-rivaroxaban-results-from-the-craft-study
#6
Paweł Balsam, Krzysztof Ozierański, Agata Tymińska, Katarzyna Żukowska, Martyna Zaleska, Katarzyna Szepietowska, Kacper Maciejewski, Michał Peller, Marcin Grabowski, Piotr Lodziński, Anna Praska-Ogińska, Inna Zaboyska, Łukasz Kołtowski, Anna Kowalczuk, Janusz Bednarski, Krzysztof J Filipiak, Grzegorz Opolski
BACKGROUND: The first line drugs for treatment of non-valvular atrial fibrillation (AF) are non-vitamin K oral anticoagulants (NOACs), which are preferred over vitamin K antagonists (VKAs). There is some evidence that an everyday clinical practice is distant from the guidelines. AIM: The study aimed to compare characteristics of patients on VKAs, dabigatran and rivaroxaban met in everyday practice (i.e. baseline characteristics, drugs' doses, risk factors of bleeding and thromboembolic events)...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29201378/time-to-re-think-the-use-of-dobutamine-in-sepsis
#7
Ryota Sato, Michitaka Nasu
Dobutamine is commonly used worldwide and included in the protocol for early goal-directed therapy (EGDT). Since the use of dobutamine in EGDT was reported, it has been considered to be an important component, especially in the treatment of septic patients with myocardial dysfunction. However, it is questionable whether dobutamine improves the mortality of sepsis and septic shock. In three recent randomized controlled trials (ProCESS, ProMISe, and ARISE trials), the frequency of dobutamine use was significantly higher in the EGDT group than in the standard care group, but there were no significant differences in the mortality between the groups...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/29183028/radiofrequency-ablation-of-atrial-fibrillation-in-patients-with-ebstein-s-anomaly-a-two-case-report
#8
Konstantinos E Iliodromitis, Marc Bonsels, Rolf Borchard, Anja Dorszewski
Ebstein's anomaly (EA) is a rare congenital heart disease characterized by "atrialization" of the right ventricle, due to apical displacement of the tricuspid leaflets into the right ventricle. Patients with EA may develop all kinds of supraventricular arrhythmias requiring radiofrequency ablation. Atrial fibrillation (Afib) is a common arrhythmia in EA patients, and results in debilitating symptoms that often require surgical treatment. This is a follow-up report of 2 patients with EA undergoing radiofrequency ablation for Afib...
2018: Cardiology
https://www.readbyqxmd.com/read/29055399/new-digital-adherence-devices-could-prevent-millions-of-strokes-from-atrial-fibrillation-by-the-end-of-the-next-century
#9
Philip Boehme, Peter Wienand, Maximilian Herrmann, Hubert Truebel, Thomas Mondritzki
The effectiveness and safety of a pharmacologic intervention is highly dependent on patient's capability to follow the recommended treatment regimen. Non-adherence to pharmacologic treatments is associated with worsening conditions including hospitalization and death. This is a significant burden to healthcare systems on a global scale with non-adherence rates being as high (or higher) as 50% in the first treatment year. The most common causes for non-adherence are forgetfulness, busy lifestyle or complexity and changes in therapeutic schedules...
October 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28942524/characteristics-of-sleep-disordered-breathing-in-patients-with-atrial-fibrillation-and-preserved-left-ventricular-ejection-fraction
#10
Johanna Strotmann, Henrik Fox, Thomas Bitter, Odile Sauzet, Dieter Horstkotte, Olaf Oldenburg
BACKGROUND: Sleep-disordered breathing (SDB) represents a common and highly relevant co-morbidity in patients with atrial fibrillation (Afib). Obstructive sleep apnea (OSA) has been identified as an independent risk factor for developing Afib and for Afib recurrence after treatment, but the role of central sleep apnea (CSA) is less clear. This study investigated characteristics of SDB in Afib patients with preserved left ventricular ejection fraction (PEF). METHODS AND RESULTS: Consecutive patients (07/2007 to 03/2016) with documented Afib at hospital admission and PEF undergoing 6-channel cardiorespiratory polygraphy (PG) screening were retrospectively analyzed...
February 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28379023/-cardiovascular-complications-of-cancers-and-anti-cancer-therapy
#11
Jiří Vyskočil, Katarína Petráková, Petr Jelínek, Michal Furdek
In our aging population the incidence of cancer is increasing in the elderly. We are thus facing a new challenge especially considering incidence of cardiovascular diseases (CVD) in this patients population. Overall survival of cancer patients has significantly improved therefore cancer has become in many cases a chronic disease. We are about to be treating patients who either may develop a new CVD or their current CVD may deteriorate. Cancer can cause various cardiovascular conditions locally (pressure in mediastinum, effusions) or systemically (increased risk of pulmonary embolism, arrhythmias, carcinoid heart disease)...
December 0: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28373155/processes-and-recommendations-for-creating-mhealth-apps-for-low-income-populations
#12
Laura Siga Stephan, Eduardo Dytz Almeida, Raphael Boesche Guimaraes, Antonio Gaudie Ley, Rodrigo Gonçalves Mathias, Maria Valéria Assis, Tiago Luiz Luz Leiria
BACKGROUND: Mobile health (mHealth) apps have shown to improve health indicators, but concerns remain about the inclusion of populations from low- and medium-income countries (LMIC) in these new technologies. Atrial fibrillation (AF) is a chronic condition with a challenging management. Previous studies have shown socioeconomic differences in the prescription of anticoagulant treatment and shared decision strategies are encouraged to achieve better outcomes. mHealth can aid both doctors and patients in this matter...
April 3, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28104790/contemporary-management-of-patients-undergoing-atrial-fibrillation-ablation-in-hospital-and-1-year-follow-up-findings-from-the-esc-ehra-atrial-fibrillation-ablation-long-term-registry
#13
MULTICENTER STUDY
Elena Arbelo, Josep Brugada, Carina Blomström-Lundqvist, Cécile Laroche, Josef Kautzner, Evgeny Pokushalov, Pekka Raatikainen, Michael Efremidis, Gerhard Hindricks, Alberto Barrera, Aldo Maggioni, Luigi Tavazzi, Nikolaos Dagres
Aims: The ESC-EHRA Atrial Fibrillation Ablation Long-Term registry is a prospective, multinational study that aims at providing an accurate picture of contemporary real-world ablation for atrial fibrillation (AFib) and its outcome. Methods and results: A total of 104 centres in 27 European countries participated and were asked to enrol 20-50 consecutive patients scheduled for first and re-do AFib ablation. Pre-procedural, procedural and 1-year follow-up data were captured on a web-based electronic case record form...
May 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/27780690/risk-of-atrial-fibrillation-and-bleeding-diathesis-associated-with-ibrutinib-treatment-a-systematic-review-and-pooled-analysis-of-four-randomized-controlled-trials
#14
Seongseok Yun, Nicole D Vincelette, Utkarsh Acharya, Ivo Abraham
BACKGROUND: Clinical trials raised concern that ibrutinib may increase the risk of atrial fibrillation/flutter (Afib/Aflutter) and major bleeding. However, the association has not been statistically validated, and there is no consensus regarding optimal management of anticoagulation among patients receiving ibrutinib who develop Afib/Aflutter. We performed a systematic review and pooled analysis to precisely assess the risk of Afib/Aflutter and bleeding associated with ibrutinib treatment in patients with hematologic malignancies...
January 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/27614403/safely-addressing-patients-with-atrial-fibrillation-to-early-anticoagulation-after-acute-stroke
#15
MULTICENTER STUDY
Isabella Canavero, Anna Cavallini, Lucia Sacchi, Silvana Quaglini, Natale Arnò, Patrizia Perrone, Maria Luisa DeLodovici, Simona Marcheselli, Giuseppe Micieli
BACKGROUND: It has been widely reported that anticoagulants (ACs) are underused for primary and secondary prevention of ischemic stroke in patients with atrial fibrillation (AFib). Furthermore, precise evidence-based guidelines about the best timing for AC initiation after acute stroke are currently lacking. METHODS AND RESULTS: In this retrospective, observational study, we analyzed prescription trends in AFib patients with acute ischemic stroke who were hospitalized in four neurologic stroke units of our region (Lombardia, Italy)...
January 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27387372/feasibility-testing-of-the-alert-for-afib-intervention
#16
Pamela J McCabe, Kristin Vickers Douglas, Debra L Barton, Christine Austin, Adriana Delgado, Holli A DeVon
Improving early detection and treatment of atrial fibrillation (AF) is critical because untreated AF is a major contributor to stroke and heart failure. We sought to generate knowledge about the feasibility of conducting a randomized controlled trial to test the effect of the Alert for AFib intervention on knowledge, attitudes, and beliefs about treatment-seeking for signs and symptoms of AF. Adults ≥65 years old (96% White) at risk for developing AF were randomized to receive the Alert for AFib intervention (n = 40) or an attention control session (n = 40)...
July 6, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/27179130/hemodynamics-associated-with-atrial-fibrillation-directly-alters-thrombotic-potential-of-endothelial-cells
#17
Michael B Simmers, Banumathi K Cole, Martin L Ogletree, Zhu Chen, Yiming Xu, Ling-Jie Kong, Nigel Mackman, Brett R Blackman, Brian R Wamhoff
An experimental in vitro model of the hemodynamics that occur in atrial fibrillation (AFib) in the left atrial appendage (LAA) was developed to study changes in human endothelial cell thrombotic potential. We applied human-derived sinus rhythm and AFib hemodynamic shear stress patterns to primary human endothelial cells (ECs) in culture. We found that ECs exposed to AFib hemodynamics have increased thrombotic potential as measured by increased expression of pro-thrombotic gene markers and fibrin deposition on the endothelium...
July 2016: Thrombosis Research
https://www.readbyqxmd.com/read/26666288/underuse-of-anticoagulation-in-patients-with-atrial-fibrillation
#18
REVIEW
Ajay Vallakati, William R Lewis
Atrial fibrillation (AF) is a major risk factor for ischemic stroke. Guidelines recommend anticoagulation for patients with intermediate and high stroke risk (CHA2DS2-VASc score ≥ 2). Underuse of anticoagulants among eligible patients remains a persistent problem. Evidence demonstrates that the psychology of the fear of causing harm (omission bias) results in physicians' hesitancy to initiate anticoagulation and an inaccurate estimation of stroke risk. The American Heart Association (AHA) initiated the Get With The Guidelines-AFIB (GWTG-AFIB) module in June 2013 to enhance guideline adherence for treatment and management of AF...
2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/26104508/antiplatelet-therapy-during-pci-for-patients-with-stable-angina-and-atrial-fibrillation
#19
REVIEW
Amjid Iqbal, Fatima Rodriguez, Henrik Schirmer
The pharmacological treatment options for anticoagulation in patients with atrial fibrillation (Afib) have increased with the introduction of novel oral anticoagulants, compared with earlier times, when vitamin K antagonist was the drug of choice. As they age, many Afib patients require percutaneous coronary intervention (PCI), necessitating antiplatelet medication in addition to anticoagulation therapy. Choosing the appropriate combination and duration of anticoagulation and antiplatelet therapies may be challenging in stable coronary artery disease (CAD) and even more complicated during and after coronary intervention with the introduction of additional antithrombotic drugs...
August 2015: Current Cardiology Reports
https://www.readbyqxmd.com/read/25745835/an-examination-of-myth-a-favorable-cardiovascular-risk-benefit-analysis-of-high-dose-thyroid-for-affective-disorders
#20
REVIEW
Tammas Kelly
INTRODUCTION: High dose thyroid (HDT) is included in major treatment guidelines for the treatment of bipolar disorders. Yet it is seldom used partly based on perceived cardiovascular risks. The cardiovascular risks of HDT are examined. METHODS: A literature search was conducted for the cardiovascular risks of HDT and for comparisons sake psychiatric medications. Case reports of atrial fibrillation (afib) associated with HDT are reported. RESULTS: While hyperthyroidism is a significant cardiovascular risk factor causing a 20% premature death rate, HDT treatment does not appear to be of significant cardiovascular risk...
May 15, 2015: Journal of Affective Disorders
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