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https://www.readbyqxmd.com/read/28557538/attention-deficit-hyperactivity-and-obsessive-compulsive-symptoms-in-adult-patients-with-primary-restless-legs-syndrome-different-phenotypes-of-the-same-disease
#1
Imad Ghorayeb, Ashley Gamas, Zoé Mazurie, Willy Mayo
OBJECTIVES: To investigate the prevalence of attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) symptoms in adult patients with primary restless legs syndrome (RLS) and to determine the iron biological correlates of these comorbidities. PARTICIPANTS AND METHODS: We obtained demographic and clinical data from consecutive 105 outpatients with idiopathic RLS who answered validated questionnaires designed to assess the presence of ADHD and OCD symptoms...
May 30, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28470381/relationship-of-serum-ferritin-level-and-tic-severity-in-children-with-tourette-syndrome
#2
Debabrata Ghosh, Elizabeth Burkman
PURPOSE: Tics can be considered hyperkinetic movements akin to restless leg syndrome (RLS). Drawing the analogy of iron deficiency as an etiology of RLS, it is conceivable that iron deficiency may underlie or worsen tics in Tourette syndrome (TS). The purpose of this study was to evaluate the relationship between serum ferritin levels and tic severity, as well as consequent impact on life, in children with TS. METHODS: Children <18 years, diagnosed with TS during 2009-2015, were reviewed...
May 3, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28345734/-restless-legs-syndrome-in-patients-diagnosed-with-attention-deficit-hyperactivity-disorder
#3
C Castano-De la Mota, N Moreno-Acero, R Losada-Del Pozo, V Soto-Insuga, A Perez-Villena, C Rodriguez-Fernandez, F Martin-Del Valle, M Pons-Rodriguez
INTRODUCTION: Restless legs syndrome (RLS) is a common neurological disease. RLS has been linked to various psychiatric disorders, especially with attention deficit hyperactivity disorder (ADHD). AIMS: The main objective was to describe the frequency of RLS in pediatric patients diagnosed with ADHD. Secondary objectives of the study were describe other sleep disorders in ADHD patients. PATIENTS AND METHODS: A multicentre prospective study was conducted in nine Spanish centers...
April 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28195837/the-effect-of-atomoxetin-use-in-the-treatment-of-attention-deficit-hyperactivity-disorder-on-the-symptoms-of-restless-legs-syndrome-a-case-report
#4
Saliha Baykal, Melih Nuri Karakurt
Attention-deficit/hyperactivity disorder (ADHD) is frequently accompanied with sleep disorders such as obstructive sleep apnea, periodic limb movement disorder, restless legs syndrome (RLS), and circadian rhythm disorder. We have limited information about the effects of medical therapies used in the treatment of ADHD on RLS. This article discusses the effects of atomoxetine treatment on both disorders in a patient followed by diagnoses of ADHD and RLS.
March 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27519964/somatic-and-neuropsychiatric-comorbidities-in-pediatric-restless-legs-syndrome-a-systematic-review-of-the-literature
#5
REVIEW
Marco Angriman, Samuele Cortese, Oliviero Bruni
Restless legs syndrome (RLS) is a relatively common neurological disorder in childhood, although it is usually overlooked due to the atypical presentation in children and associated comorbid conditions that may affect its clinical presentation. Here, we aimed to perform, for the first time, a systematic review of studies reporting the association between RLS in children and adolescents (<18 y) and somatic or neuropsychiatric conditions. We searched for peer-reviewed studies in PubMed, Ovid (including PsycINFO, Ovid MEDLINE(®), and Embase), Web of Knowledge (Web of Science, Biological abstracts, BIOSIS, FSTA) through November 2015, with no language restrictions...
July 1, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27357497/sleep-problems-in-children-with-attention-deficit-hyperactivity-disorder-current-status-of-knowledge-and-appropriate-management
#6
REVIEW
Ming-Horng Tsai, Jen-Fu Hsu, Yu-Shu Huang
Attention deficit hyperactivity disorder (ADHD) affects approximately 5 % of children and adolescents, and sleep problems are common in these patients. There is growing evidence informing the significant importance of sleep problems in youth with ADHD. The sleep problems in children with ADHD include specific sleep disorders and sleep disturbances due to comorbid psychiatric disorders or ADHD medications. The specific sleep disorders of ADHD children include behaviorally based insomnia, sleep-disordered breathing, and restless legs syndrome/periodic limb movement disorder...
August 2016: Current Psychiatry Reports
https://www.readbyqxmd.com/read/27255788/sleep-related-disorders-in-children-with-attention-deficit-hyperactivity-disorder-preliminary-results-of-a-full-sleep-assessment-study
#7
Silvia Miano, Maria Esposito, Giuseppe Foderaro, Gian Paolo Ramelli, Valdo Pezzoli, Mauro Manconi
BACKGROUND AND METHODS: We present the preliminary results of a prospective case-control sleep study in children with a diagnosis of attention-deficit hyperactivity disorder (ADHD). A deep sleep assessment including sleep questionnaires, sleep habits, a video-polysomnographic recording with full high-density electroencephalography (EEG) and cardiorespiratory polygraphy, multiple sleep latency test, and 1-week actigraphic recording were performed to verify whether children with ADHD may be classified into one of the following five phenotypes: (1) hypoarousal state, resembling narcolepsy, which may be considered a "primary" form of ADHD; (2) delayed sleep onset insomnia; (3) sleep-disordered breathing; (4) restless legs syndrome and/or periodic limb movements; and (5) sleep epilepsy and/or EEG interictal epileptiform discharges...
June 3, 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/26418664/prevalence-of-restless-legs-syndrome-in-adult-adhd-and-its-subtypes
#8
Mark A Snitselaar, Marcel G Smits, Jan Spijker
In this observational cross-sectional study, 49 subjects were assessed for sleep disorders and for ADHD symptoms. Thirty-six received an ADHD diagnosis (29: combined type (ADHD-C); 7: inattentive type). An RLS and RLS symptoms prevalence of 34.5% was found, with a higher prevalence rate in the ADHD-C subgroup, although not significantly (p = 0.066). RLS symptoms were correlated with particularly hyperactivity-impulsivity (ρ = 0.742; p: 0.000). ADHD patients with positive RLS scores reported higher scores on the ADHD-Rating scale compared with patients with negative RLS scores (Z: -2...
September 2016: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/25555628/association-between-restless-legs-syndrome-and-adult-adhd-in-a-german-community-based-sample
#9
Mandy Roy, Martina de Zwaan, Inka Tuin, Alexandra Philipsen, Elmar Brähler, Astrid Müller
OBJECTIVE: Previous research in clinical samples indicated a significant association between ADHD and restless legs syndrome (RLS). The present study examined the association between adult ADHD and RLS in the German population. METHOD: Self-rating instruments to assess RLS, childhood ADHD, and adult ADHD were administered to a community-based sample (N = 1,632). In addition, current depression and anxiety, sleep disturbances, weight, and height were assessed by self-report...
January 2, 2015: Journal of Attention Disorders
https://www.readbyqxmd.com/read/25127644/associations-of-sleep-disturbance-with-adhd-implications-for-treatment
#10
REVIEW
Allan Hvolby
Attention-deficit/hyperactivity disorder (ADHD) is commonly associated with disordered or disturbed sleep. The relationships of ADHD with sleep problems, psychiatric comorbidities and medications are complex and multidirectional. Evidence from published studies comparing sleep in individuals with ADHD with typically developing controls is most concordant for associations of ADHD with: hypopnea/apnea and peripheral limb movements in sleep or nocturnal motricity in polysomnographic studies; increased sleep onset latency and shorter sleep time in actigraphic studies; and bedtime resistance, difficulty with morning awakenings, sleep onset difficulties, sleep-disordered breathing, night awakenings and daytime sleepiness in subjective studies...
March 2015: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/25114692/prevalence-of-restless-legs-syndrome-and-sleep-problems-in-korean-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-a-single-institution-study
#11
Soonhak Kwon, Youngsoo Sohn, Seong-Hoon Jeong, Un-Sun Chung, Hyeeun Seo
PURPOSE: Attention deficit hyperactivity disorder (ADHD) is a common disorder in school-aged children. Patients with restless legs syndrome (RLS) often present with ADHD symptoms and vice versa. This study was the first to attempt to identify the prevalence of RLS and sleep problems in children with ADHD in Korea. METHODS: Patients diagnosed with ADHD were asked to complete a sleep questionnaire. The sleep questionnaire included items to help identify the presence of four typical symptoms that are used as diagnostic criteria for RLS...
July 2014: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/25095868/-a-possible-coexistence-between-restless-legs-syndrom-and-attention-deficit-hyperactivity-disorder
#12
Jørgen Tilma, Per Hove Thomsen, John R Ostergaard
Restless legs syndrome (RLS) and attention deficit hyperactivity disorder (ADHD) have consistently been found to coexist frequently. The cause for the relationship of these co-morbid disorders is contradicting, but both disorders are associated with a common dopaminergic dysfunction, low iron status, sleep disruptions and genetic linking. Well-known diagnostic criteria are necessary for early diagnosis and optimal treatment. Further investigation is needed to identify the pathogenesis, the genetic background and better validated treatment options...
February 17, 2014: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/24862749/sleep-related-breathing-disorder-is-associated-with-hyperactivity-in-preschoolers
#13
Zhimin Ren, Anli Qiu
INTRODUCTION: Sleep problems are a prominent feature in children with attention deficit hyperactivity disorder (ADHD). Unlike existing studies that focused on extreme samples (i.e. normal vs. ADHD), our study investigated the associations of sleep-related behaviours and ADHD features in nonclinical Chinese preschoolers. METHODS: All participants were recruited via advertisements and screened for eligibility through a telephone interview prior to an onsite visit...
May 2014: Singapore Medical Journal
https://www.readbyqxmd.com/read/24360552/daytime-dysfunction-in-children-with-restless-legs-syndrome
#14
Naomichi Furudate, Yoko Komada, Mina Kobayashi, Shun Nakajima, Yuichi Inoue
We investigated daytime dysfunction in children with restless legs syndrome (RLS) and the effects of treatment primarily with iron supplements on RLS symptoms and daytime dysfunction. We recruited 25 children with RLS (male:female=6:19, mean age at study onset: 12.3 years) for this prospective study, assessing their demographics, symptomatic characteristics, serum ferritin levels, and daytime functioning using the ADHD Rating Scale IV (ADHD-RS-IV), the Pediatric Symptom Checklist (PSC), and the Pediatric Quality of Life Inventory (PedsQL™)...
January 15, 2014: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/24079375/spontaneously-hypertensive-rats-possible-animal-model-of-sleep-related-movement-disorders
#15
Andrea M Esteves, Cleide Lopes, Roberto Frussa-Filho, Miriam K Frank, Daniel Cavagnolli, Ricardo M Arida, Sergio Tufik, Marco Tulio de Mello
Clinical experience suggests that restless legs syndrome (RLS), periodic leg movement (PLM), and attention-deficit hyperactivity disorder (ADHD) may co-occur in both children and adults. The purpose of the present study was to provide an electrocorticography and electromyography evaluation of the spontaneously hypertensive rat (SHR) to investigate the potential of this rat strain as an animal model of RLS-PLM. Initial work focused on evaluating sleep patterns and limb movements during sleep in SHR, having normotensive Wistar rats (NWR) as control, followed by comparison of two treatments (pharmacological-dopaminergic agonist treatment and nonpharmacological-chronic physical exercise), known to be clinically beneficial for sleep-related movement disorders...
2013: Journal of Motor Behavior
https://www.readbyqxmd.com/read/24022016/case-reports-of-sleep-phenotypes-of-adhd-from-hypothesis-to-clinical-practice
#16
Silvia Miano, Renato Donfrancesco, Pasquale Parisi, Jole Rabasco, Anna Rita Mazzotta, Alessandra Tabarrini, Ottavio Vitelli, Maria Pia Villa
OBJECTIVE: Five sleep ADHD phenotypes have been hypothesized: (a) the hypo-arousal state of the "primary" form of ADHD, (b) the sleep phase advanced disorder, (c) sleep disordered breathing (SDB), (d) restless legs syndrome and/or periodic limb movements disorder (PLMD), and (e) epilepsy. METHOD: Five case reports are presented; each child but one underwent video-polysomnography. RESULTS: The first case report is an example of ADHD and SDB, with improvement of hypersomnolence after resolution of sleep apnea...
October 2013: Journal of Attention Disorders
https://www.readbyqxmd.com/read/23880489/assessment-and-management-of-sleep-problems-in-youths-with-attention-deficit-hyperactivity-disorder
#17
REVIEW
Samuele Cortese, Thomas E Brown, Penny Corkum, Reut Gruber, Louise M O'Brien, Mark Stein, Margaret Weiss, Judith Owens
OBJECTIVE: To provide evidence- or consensus-based recommendations concerning the assessment and management of sleep problems in youths with attention-deficit/hyperactivity disorder (ADHD). METHOD: PubMed, Ovid, EMBASE, and Web of Knowledge were searched through October 31, 2012. When no evidence was available, consensus of the authors was achieved. The evidence-level of the recommendations on the management of sleep disturbances was based on the Scottish Intercollegiate Guidelines Network (SIGN) system...
August 2013: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/23415543/time-structure-of-leg-movement-activity-during-sleep-in-attention-deficit-hyperactivity-disorder-and-effects-of-levodopa
#18
RANDOMIZED CONTROLLED TRIAL
Raffaele Ferri, Oliviero Bruni, Luana Novelli, Matthew A Picchietti, Daniel L Picchietti
OBJECTIVES: To evaluate the leg movement (LM) time structure (periodicity and night distribution) during sleep in children with attention-deficit/hyperactivity disorder (ADHD) and their eventual changes after treatment with levodopa (L-DOPA). SUBJECTS AND METHODS: One group of ADHD patients (n=18) and another group of normal controls (n=17) were recruited; those with ADHD were randomized to L-DOPA or placebo therapy. At baseline (both groups) and after therapy (only patients) subjects underwent full-night polysomnography (PSG) and the leg motor pattern was evaluated with advanced tools of analysis particularly able to detect and describe LM time structure (periodicity and distribution)...
April 2013: Sleep Medicine
https://www.readbyqxmd.com/read/23082739/iron-and-attention-deficit-hyperactivity-disorder-what-is-the-empirical-evidence-so-far-a-systematic-review-of-the-literature
#19
REVIEW
Samuele Cortese, Marco Angriman, Michel Lecendreux, Eric Konofal
The authors systematically reviewed evidence on iron status, as well as studies of iron supplementation, in individuals with attention deficit/hyperactivity disorder (ADHD). PubMed, Ovid, EMBASE and Web of Knowledge were searched on 4 July 2012. Quantitative appraisal of trials was performed using Jadad's score. Most (n = 20) of the retrieved studies assessed an index of peripheral iron status (i.e., serum ferritin), with overall mixed results - that is, both significant and nonsignificant association between ADHD symptoms and serum ferritin levels...
October 2012: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/22608760/the-sleep-phenotypes-of-attention-deficit-hyperactivity-disorder-the-role-of-arousal-during-sleep-and-implications-for-treatment
#20
Silvia Miano, Pasquale Parisi, Maria Pia Villa
About 25-50% of children and adolescents with attention-deficit hyperactivity disorder (ADHD) experience sleep problems. An appropriate assessment and treatment of such problems might improve the quality of life in such patients and reduce both the severity of ADHD and the impairment it causes. According to data in the literature and to the overall complexity of the interaction between ADHD and sleep, five sleep phenotypes may be identified in ADHD: (i) a sleep phenotype characterized mainly by a hypo-arousal state, resembling narcolepsy, which may be considered a "primary" form of ADHD (i...
August 2012: Medical Hypotheses
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