Jean Claude S Ngabonziza, Leen Rigouts, Gabriela Torrea, Tom Decroo, Eliane Kamanzi, Pauline Lempens, Aniceth Rucogoza, Yves M Habimana, Lies Laenen, Belamo E Niyigena, Cécile Uwizeye, Bertin Ushizimpumu, Wim Mulders, Emil Ivan, Oren Tzfadia, Claude Mambo Muvunyi, Patrick Migambi, Emmanuel Andre, Jean Baptiste Mazarati, Dissou Affolabi, Alaine N Umubyeyi, Sabin Nsanzimana, Françoise Portaels, Michel Gasana, Bouke C de Jong, Conor J Meehan
SUMMARY BACKGROUND: Multidrug-resistant (MDR) tuberculosis (TB) poses an important challenge in TB management and control. Rifampicin resistance (RR) is a solid surrogate marker of MDR-TB. We investigated the RR-TB clustering rates, bacterial population dynamics to infer transmission dynamics, and the impact of changes to patient management on these dynamics over 27 years in Rwanda. METHODS: We analysed whole genome sequences of a longitudinal collection of nationwide RR-TB isolates...
May 2022: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases