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MR elastography

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https://www.readbyqxmd.com/read/28493802/placental-imaging-normal-appearance-with-review-of-pathologic-findings
#1
Shaimaa Fadl, Mariam Moshiri, Corinne L Fligner, Douglas S Katz, Manjiri Dighe
The placenta plays a crucial role throughout pregnancy, and its importance may be overlooked during routine antenatal imaging evaluation. Detailed systematic assessment of the placenta at ultrasonography (US), the standard imaging examination during pregnancy, is important. Familiarity with the normal and abnormal imaging appearance of the placenta along with the multimodality and methodical approach for evaluation of its related abnormalities is necessary, so that radiologists can alert clinicians regarding appropriate prompt management decisions...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28493388/magnetic-resonance-elastography-measured-shear-stiffness-as-a-biomarker-of-fibrosis-in-pediatric-nonalcoholic-fatty-liver-disease
#2
Jeffrey B Schwimmer, Cynthia Behling, Jorge Eduardo Angeles, Melissa Paiz, Janis Durelle, Jonathan Africa, Kimberly P Newton, Elizabeth M Brunt, Joel E Lavine, Stephanie H Abrams, Prakash Masand, Rajesh Krishnamurthy, Kelvin Wong, Richard L Ehman, Meng Yin, Kevin J Glaser, Bogdan Dzyubak, Tanya Wolfson, Anthony C Gamst, Jonathan Hooker, William Haufe, Alexandra Schlein, Gavin Hamilton, Michael S Middleton, Claude B Sirlin
Magnetic Resonance Elastography (MRE) is promising for non-invasive assessment of fibrosis, a major determinant of outcome in nonalcoholic fatty liver disease (NAFLD). However, data in children are limited. Study aims were to determine accuracy of MRE for detection of fibrosis and advanced fibrosis in children with NAFLD, and to assess agreement between manual and novel automated reading methods. We performed a prospective, multi-center study of 2D-MRE in children with NAFLD. MR-elastograms were analyzed manually at 2 reading centers and using a new automated technique...
May 11, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28488326/acute-pressure-changes-in-the-brain-are-correlated-with-mr-elastography-stiffness-measurements-initial-feasibility-in-an-in-vivo-large-animal-model
#3
Arvin Arani, Hoon-Ki Min, Nikoo Fattahi, Nicholas M Wetjen, Joshua D Trzasko, Armando Manduca, Clifford R Jack, Kendall H Lee, Richard L Ehman, John Huston
PURPOSE: The homeostasis of intracranial pressure (ICP) is of paramount importance for maintaining normal brain function. A noninvasive technique capable of making direct measurements of ICP currently does not exist. MR elastography (MRE) is capable of noninvasively measuring brain tissue stiffness in vivo, and may act as a surrogate to measure ICP. The objective of this study was to investigate the impact of changing ICP on brain stiffness using MRE in a swine model. METHODS: Baseline MRE measurements were obtained, and then catheters were surgically placed into the left and right lateral ventricles of three animals...
May 9, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28473066/acr-appropriateness-criteria-%C3%A2-chronic-liver%C3%A2-disease
#4
Jeanne M Horowitz, Ihab R Kamel, Hina Arif-Tiwari, Sumeet K Asrani, Nicole M Hindman, Harmeet Kaur, Michelle M McNamara, Richard B Noto, Aliya Qayyum, Tasneem Lalani
Because liver fibrosis can be treated, it is important to diagnose liver fibrosis noninvasively and monitor response to treatment. Although ultrasound (grayscale and Doppler) can diagnose cirrhosis, it does so unreliably using morphologic and sonographic features and cannot diagnose the earlier, treatable stages of hepatic fibrosis. Transient elastography, ultrasound elastography with acoustic radiation force impulse, and MR elastography are modalities that can assess for hepatic fibrosis. Although all international organizations recommend ultrasound for screening for hepatocellular carcinoma, ultrasound is particularly limited for identifying hepatocellular carcinoma in patients with obesity, nonalcoholic fatty liver disease, and nodular cirrhotic livers...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28471737/mr-elastography-derived-stiffness-a-biomarker-for-intervertebral-disc-degeneration
#5
Benjamin A Walter, Prasath Mageswaran, Xiaokui Mo, Daniel J Boulter, Hazem Mashaly, Xuan V Nguyen, Luciano M Prevedello, William Thoman, Brian D Raterman, Prateek Kalra, Ehud Mendel, William S Marras, Arunark Kolipaka
Purpose To determine the repeatability of magnetic resonance (MR) elastography-derived shear stiffness measurements of the intervertebral disc (IVD) taken throughout the day and their relationship with IVD degeneration and subject age. Materials and Methods In a cross-sectional study, in vivo lumbar MR elastography was performed once in the morning and once in the afternoon in 47 subjects without current low back pain (IVDs = 230; age range, 20-71 years) after obtaining written consent under approval of the institutional review board...
May 4, 2017: Radiology
https://www.readbyqxmd.com/read/28426437/supersonic-transient-magnetic-resonance-elastography-for-quantitative-assessment-of-tissue-elasticity
#6
Yu Liu, Jingfei Liu, Brett Z Fite, Josquin Foiret, Asaf Ilovitsh, J Kent Leach, Erik Dumont, Charles F Caskey, Katherine W Ferrara
Non-invasive, quantitative methods to assess the properties of biological tissues are needed for many therapeutic and tissue engineering applications. Magnetic resonance elastography (MRE) has historically relied on external vibration to generate periodic shear waves. In order to focally assess a biomaterial or to monitor the response to ablative therapy, the interrogation of a specific region of interest by a focused beam is desirable and transient MRE (t-MRE) techniques have previously been developed to accomplish this goal...
May 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28425401/mre-in-nafld-promising-but-further-validation-is-required
#7
John D Ryan, Emmanuel A Tsochatzis
MR elastography is a novel method for non-invasive fibrosis assessment, not yet sufficiently validated. In a recent study in 104 patients Park, Gastroenterology 2017; 152: 598-602), MRE was compared to transient elastography for the diagnosis of fibrosis is nonalcoholic fatty liver disease. The current viewpoint critically appraises this study.
May 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28422391/mr-elastography-detection-of-early-viscoelastic-response-of-the-murine-hippocampus-to-amyloid-%C3%AE-accumulation-and-neuronal-cell-loss-due-to-alzheimer-s-disease
#8
Tonia Munder, Anna Pfeffer, Stefanie Schreyer, Jing Guo, Juergen Braun, Ingolf Sack, Barbara Steiner, Charlotte Klein
PURPOSE: To investigate in vivo viscoelastic parameters related to early histopathological changes in the hippocampus and the cortex in early, preclinical Alzheimer's disease (AD) stages. MATERIALS AND METHODS: Magnetic resonance elastography (MRE) was applied to female APP23 mice, an established transgenic mouse model of AD, at three different stages early in disease progression. To investigate the potential therapeutic effects of physical, cognitive, and social stimulation on brain viscoelasticity and histopathological characteristics, MRE was also applied after exposing young APP23 mice to environmentally enriched cage conditions (ENR), for 1, 12, or 24 weeks, which corresponds to adolescent, young-adult, and adult age at the time of analysis...
April 19, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28367603/mr-elastography-high-rate-of-technical-success-in-pediatric-and-young-adult-patients
#9
Madalsa Joshi, Jonathan R Dillman, Alexander J Towbin, Suraj D Serai, Andrew T Trout
BACKGROUND: Magnetic resonance (MR) elastography allows the noninvasive assessment of liver stiffness, which is a surrogate for fibrosis. OBJECTIVE: The purpose of this study was to describe our experience using liver MR elastography in a large pediatric population with attention to the frequency and causes of exam failure. MATERIALS AND METHODS: Imaging records were searched for patients ≤18 years of age who underwent 2-D gradient recalled echo (GRE) MR elastography of the liver between September 2011 and August 2015 on one of two 1...
April 3, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28344811/the-role-of-imaging-in-the-diagnosis-of-primary-prostate-cancer
#10
Hugh Harvey, Nandita M deSouza
Ultrasound and magnetic resonance imaging (MRI) are key imaging modalities in prostate cancer diagnosis. MRI offers a range of intrinsic contrast mechanisms (T2, diffusion-weighted imaging (DWI), MR spectroscopy (MRS)) and extrinsic contrast-generating options based on tumour vascular state following injection of weakly paramagnetic agents such as gadolinium. Together these parameters are referred to as multiparametric (mp)MRI and are used for detecting and guiding biopsy and staging prostate cancer. Although sensitivity of mpMRI is <75% for disease detection, specificity is >90% and a standardised reporting system together with MR-guided targeted biopsy is the optimal diagnostic pathway...
December 2016: Journal of Clinical Urology
https://www.readbyqxmd.com/read/28333623/a-comparison-of-fem-based-inversion-algorithms-local-frequency-estimation-and-direct-inversion-approach-used-in-mr-elastography
#11
Mohammad Honarvar, Ramin Sahebjavaher, Robert Rohling, Septimiu Salcudean
In quantitative elastography, maps of the mechanical properties of soft tissue, or elastograms, are calculated from the measured displacement data by solving an inverse problem. The model assumptions have a significant effect on elastograms. Motivated by the high sensitivity of imaging results to the model assumptions for in-vivo Magnetic Resonance Elastography (MRE) of the prostate, we compared elastograms obtained with four different methods. Two FEM-based methods developed by our group were compared with two other commonly used methods, Local Frequency Estimator (LFE) and curl-based Direct Inversion (c-DI)...
March 22, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28321914/a-compact-0-5%C3%A2-t-mr-elastography-device-and-its-application-for-studying-viscoelasticity-changes-in-biological-tissues-during-progressive-formalin-fixation
#12
Jürgen Braun, Heiko Tzschätzsch, Clara Körting, Angela Ariza de Schellenberger, Marika Jenderka, Toni Drießle, Michael Ledwig, Ingolf Sack
PURPOSE: To develop a method of compact tabletop magnetic resonance elastography (MRE) for rheological tests of tissue samples and to measure changes in viscoelastic powerlaw constants of liver and brain tissue during progressive fixation. METHODS: A 10-mm bore, 0.5-T permanent-magnet-based MRI system was equipped with a gradient-amplifier-controlled piezo-actuator and motion-sensitive spin echo sequence for inducing and measuring harmonic shear vibrations in cylindrical samples...
March 20, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28289936/comparison-of-spin-echo-echoplanar-imaging-and-gradient-recalled-echo-based-mr-elastography-at-3-tesla-with-and-without-gadoxetic-acid-administration
#13
Yong Seek Kim, Ji Soo Song, Stephan Kannengiesser, Seung Young Seo
OBJECTIVE: To compare spin-echo echoplanar imaging (SE-EPI) and gradient recalled echo (GRE) MR elastography (MRE) at 3 T with and without gadoxetic acid administration. METHODS: We included 84 patients who underwent MRE before and after gadoxetic acid administration, each time using SE-EPI and GRE sequences. Diagnostic performance for predicting clinical liver cirrhosis and high-risk oesophageal varices was assessed using the area under the receiver-operating characteristic curve (AUC)...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28277807/magnetic-resonance-imaging-and-transient-elastography-in-the-management-of-nonalcoholic-fatty-liver-disease-nafld
#14
REVIEW
Ma Ai Thanda Han, Rola Saouaf, Walid Ayoub, Tsuyoshi Todo, Edward Mena, Mazen Noureddin
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and cirrhosis worldwide and the second most common cause of liver transplantation in major medical centers. Because liver steatosis and fibrosis severity are related to disease morbidity and mortality, the extent of disease, and disease progression, they need to be assessed and monitored. In addition, innovation with new drug developments requires disease staging and monitoring in both phase 2 and 3 clinical trials. Currently, disease assessment in both clinical practice and research is mostly performed by liver biopsy, an invasive, procedure with risks...
April 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28252868/early-diagnosis-and-severity-assessment-of-acute-pancreatitis-ap-using-mr-elastography-mre-with-spin-echo-echo-planar-imaging
#15
Yu Shi, Ying Liu, Yan-Qing Liu, Feng Gao, Jia-Hui Li, Qiu-Ju Li, Qi-Yong Guo
PURPOSE: To evaluate the accuracy of magnetic resonance elastography (MRE) in comparison to contrast-enhanced computed tomography (CE-CT) for early diagnosis and prediction of severity in acute pancreatitis (AP). MATERIALS AND METHODS: This cross-sectional prospective study included 76 patients with suspected AP who underwent both CE-CT and 3.0T MRE within 24 hours of hospital admission. Pancreatic stiffness, CT severity index (CTSI), Acute Physiology and Chronic Health Evaluation (APACHE)-II, and Bedside Index for Severity in AP (BISAP) scores were comparatively evaluated using data from the first 24 hours of admission, and diagnosis and severity of AP were confirmed according to the revised Atlanta Classification (2012)...
March 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28236336/cardiac-mr-elastography-for-quantitative-assessment-of-elevated-myocardial-stiffness-in-cardiac-amyloidosis
#16
Arvin Arani, Shivaram P Arunachalam, Ian C Y Chang, Francis Baffour, Phillip J Rossman, Kevin J Glaser, Joshua D Trzasko, Kiaran P McGee, Armando Manduca, Martha Grogan, Angela Dispenzieri, Richard L Ehman, Philip A Araoz
PURPOSE: To evaluate if cardiac magnetic resonance elastography (MRE) can measure increased stiffness in patients with cardiac amyloidosis. Myocardial tissue stiffness plays an important role in cardiac function. A noninvasive quantitative imaging technique capable of measuring myocardial stiffness could aid in disease diagnosis, therapy monitoring, and disease prognostic strategies. We recently developed a high-frequency cardiac MRE technique capable of making noninvasive stiffness measurements...
February 25, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28218814/mr-elastography-measurement-of-the-effect-of-passive-warmup-prior-to-eccentric-exercise-on-thigh-muscle-mechanical-properties
#17
Paul Kennedy, Lewis J Macgregor, Eric Barnhill, Curtis L Johnson, Michael Perrins, Angus Hunter, Colin Brown, Edwin J R van Beek, Neil Roberts
PURPOSE: To investigate the effect of warmup by application of the thermal agent Deep Heat (DH) on muscle mechanical properties using magnetic resonance elastography (MRE) at 3T before and after exercise-induced muscle damage (EIMD). MATERIALS AND METHODS: Twenty male participants performed an individualized protocol designed to induce EIMD in the quadriceps. DH was applied to the thigh in 50% of the participants before exercise. MRE, T2 -weighted MRI, maximal voluntary contraction (MVC), creatine kinase (CK) concentration, and muscle soreness were measured before and after the protocol to assess EIMD effects...
February 20, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28194925/slip-interface-imaging-based-on-mr-elastography-preoperatively-predicts-meningioma-brain-adhesion
#18
Ziying Yin, Joshua D Hughes, Kevin J Glaser, Armando Manduca, Jamie Van Gompel, Michael J Link, Anthony Romano, Richard L Ehman, John Huston
PURPOSE: To investigate the ability of slip interface imaging (SII), a recently developed magnetic resonance elastography (MRE)-based technique, to predict the degree of meningioma-brain adhesion, using findings at surgery as the reference standard. MATERIALS AND METHODS: With Institutional Review Board approval and written informed consent, 25 patients with meningiomas >2.5 cm in maximal diameter underwent preoperative SII assessment. Intracranial shear motions were introduced using a soft, pillow-like head driver and the resulting displacement field was acquired with an MRE pulse sequence on 3T MR scanners...
February 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28164361/in-vivo-quantification-of-aortic-stiffness-using-mr-elastography-in-hypertensive-porcine-model
#19
Huiming Dong, Ria Mazumder, Venkata Sita Priyanka Illapani, Xiaokui Mo, Richard D White, Arunark Kolipaka
PURPOSE: Aortic stiffness plays an important role in evaluating and predicting the progression of systemic arterial hypertension (SAH). The aim of this study is to determine the stiffness of aortic wall using MR elastography (MRE) in a hypertensive porcine model and compare it against invasive aortic pressure measurements. METHODS: Renal wrapping surgery was performed on eight pigs to induce SAH. Aortic MRE was performed at baseline and 2 months postsurgery using a retrospectively pulse-gated gradient-echo MRE sequence on a 1...
February 5, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28154910/value-of-tumor-stiffness-measured-with-mr-elastography-for-assessment-of-response-of-hepatocellular-carcinoma-to-locoregional-therapy
#20
Sonja Gordic, Jad Bou Ayache, Paul Kennedy, Cecilia Besa, Mathilde Wagner, Octavia Bane, Richard L Ehman, Edward Kim, Bachir Taouli
PURPOSE: The aim of the study was to correlate tumor stiffness (TS) measured with MR elastography (MRE) with degree of tumor enhancement and necrosis on contrast-enhanced T1-weighted imaging (CE-T1WI) in hepatocellular carcinomas (HCC) treated with Yttrium-90 radioembolization (RE) or transarterial chemoembolization plus radiofrequency ablation (TACE/RFA). MATERIAL AND METHODS: This retrospective study was IRB-approved and the requirement for informed consent was waived...
February 2, 2017: Abdominal Radiology
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