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MR elastography

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https://www.readbyqxmd.com/read/29774974/stiffness-reconstruction-methods-for-mr-elastography
#1
Daniel Fovargue, David Nordsletten, Ralph Sinkus
Assessment of tissue stiffness is desirable for clinicians and researchers, as it is well established that pathophysiological mechanisms often alter the structural properties of tissue. Magnetic resonance elastography (MRE) provides an avenue for measuring tissue stiffness and has a long history of clinical application, including staging liver fibrosis and stratifying breast cancer malignancy. A vital component of MRE consists of the reconstruction algorithms used to derive stiffness from wave-motion images by solving inverse problems...
May 18, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29774594/in-vivo-characterization-of-3d-skull-and-brain-motion-during-dynamic-head-vibration-using-magnetic-resonance-elastography
#2
Ziying Yin, Yi Sui, Joshua D Trzasko, Phillip J Rossman, Armando Manduca, Richard L Ehman, John Huston
PURPOSE: To introduce newly developed MR elastography (MRE)-based dual-saturation imaging and dual-sensitivity motion encoding schemes to directly measure in vivo skull-brain motion, and to study the skull-brain coupling in volunteers with these approaches. METHODS: Six volunteers were scanned with a high-performance compact 3T-MRI scanner. The skull-brain MRE images were obtained with a dual-saturation imaging where the skull and brain motion were acquired with fat- and water-suppression scans, respectively...
May 17, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29761275/quantitative-transrectal-shear-wave-elastography-undergoing-salvage-extraperitoneal-laparoscopic-radical-prostatectomy-following-failed-radiotherapy
#3
Cheng Wei, Magdalena Szewczyk-Bieda, Paddy Nibblok, E Brown, Stephen Lang, Ghulam Nabi
BACKGROUND: To evaluate pre-surgical quantitative transrectal shear wave elastography (SWE) in the detection and characterisation of radioresistant prostate cancer. METHODS: Twelve men with recurrent prostate cancer following external beam radiotherapy were included in a prospective protocol-driven study. All underwent MR imaging and quantitative shear wave elastographic assessment of recurrent disease prior to salvage laparoscopic radical prostatectomy procedures...
May 14, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29727498/frequency-dependent-shear-properties-of-annulus-fibrosus-and-nucleus-pulposus-by-magnetic-resonance-elastography
#4
P F Beauchemin, P V Bayly, J R Garbow, J L S Schmidt, R J Okamoto, F Chériet, D Périé
Aging and degeneration are associated with changes in mechanical properties in the intervertebral disc, generating interest in the establishment of mechanical properties as early biomarkers for the degenerative cascade. Magnetic resonance elastography (MRE) of the intervertebral disc is usually limited to the nucleus pulposus, as the annulus fibrosus is stiffer and less hydrated. The objective of this work was to adapt high-frequency needle MRE to the characterization of the shear modulus of both the nucleus pulposus and annulus fibrosus...
May 4, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29718694/feasibility-and-agreement-of-stiffness-measurements-using-gradient-echo-and-spin-echo-mr-elastography-sequences-in-unselected-patients-undergoing-liver-mri
#5
Guilherme M Cunha, Kevin J Glaser, Anke Bergman, Rodrigo P Luz, Eduardo Figueiredo, Flavia Paiva Proença Lobo Lopes
OBJECTIVE: To evaluate the agreement of three MRE sequences in patients undergoing liver MRI for clinical care. METHODS: A cross-sectional retrospective study was performed with 223 patients referred for liver MRI, including 12 patients with liver iron overload. Data obtained with Spin-Echo (SE) and Gradient-Echo (GRE) MRE sequences were compared. Multiple linear regression adjusted for the presence of liver fat was also performed to assess the correlation between fat infiltration and stiffness measurements results...
May 2, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29705042/pre-clinical-mr-elastography-principles-techniques-and-applications
#6
P V Bayly, J R Garbow
Magnetic resonance elastography (MRE) is a method for measuring the mechanical properties of soft tissue in vivo, non-invasively, by imaging propagating shear waves in the tissue. The speed and attenuation of waves depends on the elastic and dissipative properties of the underlying material. Tissue mechanical properties are essential for biomechanical models and simulations, and may serve as markers of disease, injury, development, or recovery. MRE is already established as a clinical technique for detecting and characterizing liver disease...
April 25, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29676964/advanced-imaging-techniques-in-evaluation-of-colorectal-cancer
#7
Roberto García-Figueiras, Sandra Baleato-González, Anwar R Padhani, Antonio Luna-Alcalá, Ana Marhuenda, Joan C Vilanova, Iria Osorio-Vázquez, Anxo Martínez-de-Alegría, Antonio Gómez-Caamaño
Imaging techniques are clinical decision-making tools in the evaluation of patients with colorectal cancer (CRC). The aim of this article is to discuss the potential of recent advances in imaging for diagnosis, prognosis, therapy planning, and assessment of response to treatment of CRC. Recent developments and new clinical applications of conventional imaging techniques such as virtual colonoscopy, dual-energy spectral computed tomography, elastography, advanced computing techniques (including volumetric rendering techniques and machine learning), magnetic resonance (MR) imaging-based magnetization transfer, and new liver imaging techniques, which may offer additional clinical information in patients with CRC, are summarized...
April 20, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29664337/pancreatic-stiffness-quantified-with-mr-elastography-relationship-to-postoperative-pancreatic-fistula-after-pancreaticoenteric-anastomosis
#8
Yu Shi, Ying Liu, Feng Gao, Yanqing Liu, Shengzhen Tao, Yue Li, Kevin J Glaser, Richard L Ehman, Qiyong Guo
Purpose To describe the relationship between conventional magnetic resonance (MR) imaging parameters and MR elastography of the pancreas in association with pancreatic histologic features and occurrence of postoperative pancreatic fistula (POPF). Materials and Methods Patients who underwent preoperative MR imaging (MR elastography and diffusion-, T1-, and T2-weighted imaging) followed by pancreatectomy with pancreaticoenteric anastomosis were included. The relationships between preoperative MR imaging parameters, demographic data, and intraoperative factors with POPF risk were analyzed with logistic regression analyses...
April 17, 2018: Radiology
https://www.readbyqxmd.com/read/29656880/fundamentals-of-functional-imaging-ii-emerging-mr-techniques-and-new-methods-of-analysis
#9
A Luna, T Martín Noguerol, L Alcalá Mata
Current multiparameter MRI protocols integrate structural, physiological, and metabolic information about cancer. Emerging techniques such as arterial spin-labeling (ASL), blood oxygen level dependent (BOLD), MR elastography, chemical exchange saturation transfer (CEST), and hyperpolarization provide new information and will likely be integrated into daily clinical practice in the near future. Furthermore, there is great interest in the study of tumor heterogeneity as a prognostic factor and in relation to resistance to treatment, and this interest is leading to the application of new methods of analysis of multiparametric protocols...
April 12, 2018: Radiología
https://www.readbyqxmd.com/read/29629807/clinical-feasibility-of-mr-elastography-in-patients-with-biliary-obstruction
#10
Dong Kyu Kim, Jin Young Choi, Mi-Suk Park, Myeong-Jin Kim, Yong Eun Chung
OBJECTIVE: The purpose of this study is to evaluate the clinical effect of liver stiffness measured using MR elastography (MRE) in patients with cholestasis due to biliary obstruction. MATERIALS AND METHODS: In this retrospective study, 69 consecutive patients with no history of diffuse liver disease who underwent pancreaticobiliary imaging with MRE were included. Quantitative MRI parameters (i.e., liver stiffness, apparent diffusion coefficient, R2*, and proton density fat fraction) and laboratory results (i...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29626258/mr-elastography-in-primary-sclerosing-cholangitis-correlating-liver-stiffness-with-bile-duct-strictures-and-parenchymal-changes
#11
Candice A Bookwalter, Sudhakar K Venkatesh, John E Eaton, Thomas D Smyrk, Richard L Ehman
AIM: To determine correlation of liver stiffness measured by MR Elastography (MRE) with biliary abnormalities on MR Cholangiopancreatography (MRCP) and MRI parenchymal features in patients with primary sclerosing cholangitis (PSC). METHODS: Fifty-five patients with PSC who underwent MRI of the liver with MRCP and MRE were retrospectively evaluated. Two board-certified abdominal radiologists in agreement reviewed the MRI, MRCP, and MRE images. The biliary tree was evaluated for stricture, dilatation, wall enhancement, and thickening at segmental duct, right main duct, left main duct, and common bile duct levels...
April 7, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29572891/novel-link-between-gut-microbiome-derived-metabolite-and-shared-gene-effects-with-hepatic-steatosis-and-fibrosis-in-nafld
#12
Cyrielle Caussy, Cynthia Hsu, Min-Tzu Lo, Amy Liu, Ricki Bettencourt, Veeral H Ajmera, Shirin Bassirian, Jonathan Hooker, Ethan Sy, Lisa Richards, Nicholas Schork, Bernd Schnabl, David A Brenner, Claude B Sirlin, Chi-Hua Chen, Rohit Loomba
Previous studies have shown that gut-microbiome is associated with nonalcoholic fatty liver disease (NAFLD). We aimed to examine if serum metabolites especially those derived from the gut-microbiome have a shared gene-effect with hepatic steatosis and fibrosis. This is a cross-sectional analysis of a prospective discovery cohort including 156 well-characterized Twins and Families with untargeted metabolome profiling assessment. Hepatic steatosis was assessed using magnetic-resonance-imaging proton-density-fat-fraction (MRI-PDFF) and fibrosis using MR-elastography (MRE)...
March 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29549474/contributions-of-magnetic-resonance-imaging-to-gastroenterological-practice-mris-for-gis
#13
REVIEW
Christopher G Roth, Dina Halegoua-De Marzio, Flavius F Guglielmo
MRI has transformed from the theoretical, investigative realm to mainstream clinical medicine over the past four decades and has become a core component of the diagnostic toolbox in the practice of gastroenterology (GI). Its success is attributable to exquisite contrast and the ability to isolate specific proton species through the use of different pulse sequences (i.e., T1-weighted, T2-weighted, diffusion-weighted) and exploiting extracellular and hepatobiliary contrast agents. Consequently, MRI has gained preeminence in various GI clinical applications: liver and pancreatic lesion evaluation and detection, liver transplantation evaluation, pancreatitis evaluation, Crohn's disease evaluation (using MR enterography) rectal cancer staging and perianal fistula evaluation...
March 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29537715/magnetic-resonance-elastography-and-t-1-mapping-for-early-diagnosis-and-classification-of-chronic-pancreatitis
#14
Min Wang, Feng Gao, Xiaoqi Wang, Yanqing Liu, Ruoyun Ji, Lizhuo Cang, Yu Shi
BACKGROUND: Early detection and classification of chronic pancreatitis (CP) are both important and challenging. PURPOSE: To investigate the diagnostic performance of MR elastography (MRE) and T1 mapping of the pancreas for different stages of CP. STUDY TYPE: Retrospective. SUBJECTS: Clinical and imaging records of 81 patients (from 5/2015 to 7/2017) with suspected CP were analyzed. Patients were categorized into the normal control (n = 35), mild CP (n = 30), and moderate/severe CP groups (n = 16) according to the Cambridge Classification based on concordant endoscopic retrograde cholangiopancreatography or ultrasound endoscopy findings...
March 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29483049/virtual-palpation-the-role-of-mr-elastography-in-quantifying-and-spatially-resolving-tissue-stiffness-as-a-biomarker-of-disease
#15
Kiaran P McGee
No abstract text is available yet for this article.
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29471562/can-elastography-differentiate-isolated-fatty-liver-from-nonalcoholic-steatohepatitis
#16
Veeral Ajmera, Rohit Loomba
Ultrasound and magnetic resonance (MR)-based elastography have demonstrated excellent performance for noninvasive staging of fibrosis in patients with nonalcoholic fatty liver disease (NAFLD); however, their ability to differentiate isolated fatty liver from nonalcoholic steatohepatitis (NASH) is unclear. In this review, the authors provide background on elastography and review the ability of elastography to discriminate between isolated steatosis and NASH. Studies with available data on the diagnosis of NASH histology are limited to vibration-controlled transient elastography and MR elastography...
February 2018: Seminars in Liver Disease
https://www.readbyqxmd.com/read/29470938/diagnostic-performance-of-mr-elastography-for-liver-fibrosis-in-children-and-young-adults-with-a-spectrum-of-liver-diseases
#17
Andrew T Trout, Rachel M Sheridan, Suraj D Serai, Stavra A Xanthakos, Weizhe Su, Bin Zhang, Daniel B Wallihan
Purpose To assess the diagnostic performance of magnetic resonance (MR) elastography-derived liver stiffness to detect liver fibrosis in a pediatric and young adult population with a spectrum of liver diseases. Materials and Methods This retrospective study included patients younger than 21 years of age who underwent MR elastography and liver biopsy within 3 months of one another between January 2012 and September 2016 for indications other than liver transplantation or Fontan palliation of congenital heart disease...
February 22, 2018: Radiology
https://www.readbyqxmd.com/read/29462024/characterization-of-small-renal-tumors-with-magnetic-resonance-elastography-a-feasibility-study
#18
Davide Prezzi, Radhouene Neji, Christian Kelly-Morland, Hema Verma, Tim OʼBrien, Ben Challacombe, Archana Fernando, Ashish Chandra, Ralph Sinkus, Vicky Goh
OBJECTIVES: The aim of this study was to explore the feasibility of magnetic resonance elastography (MRE) for characterizing indeterminate small renal tumors (SRTs) as part of a multiparametric magnetic resonance (MR) imaging protocol. MATERIALS AND METHODS: After institutional review board approval and informed consent were obtained, 21 prospective adults (15 men; median age, 55 years; age range, 25-72 years) with SRT were enrolled. Tumors (2-5 cm Ø) were imaged using 3-directional, gradient echo MRE...
June 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29461949/quantitative-elastography-methods-in-liver-disease-current-evidence-and-future-directions
#19
REVIEW
Paul Kennedy, Mathilde Wagner, Laurent Castéra, Cheng William Hong, Curtis L Johnson, Claude B Sirlin, Bachir Taouli
Chronic liver diseases often result in the development of liver fibrosis and ultimately, cirrhosis. Treatment strategies and prognosis differ greatly depending on the severity of liver fibrosis, thus liver fibrosis staging is clinically relevant. Traditionally, liver biopsy has been the method of choice for fibrosis evaluation. Because of liver biopsy limitations, noninvasive methods have become a key research interest in the field. Elastography enables the noninvasive measurement of tissue mechanical properties through observation of shear-wave propagation in the tissue of interest...
March 2018: Radiology
https://www.readbyqxmd.com/read/29460073/progressive-supranuclear-palsy-and-idiopathic-parkinson-s-disease-are-associated-with-local-reduction-of-in-vivo-brain-viscoelasticity
#20
Axel Lipp, Cornelia Skowronek, Andreas Fehlner, Kaspar-Josche Streitberger, Jürgen Braun, Ingolf Sack
OBJECTIVES: To apply three-dimensional multifrequency MR-elastography (3DMRE) for the measurement of local cerebral viscoelasticity changes in patients with Parkinson's disease (PD) and progressive supranuclear palsy (PSP). METHODS: T1-weighted anatomical imaging and 3DMRE were performed in 17 PD and 20 PSP patients as well as 12 controls. Two independent viscoelasticity parameters, |G*| and φ, were reconstructed combining seven harmonic vibration frequencies (30-60 Hz)...
February 19, 2018: European Radiology
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