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https://www.readbyqxmd.com/read/29931797/effects-of-living-at-moderate-altitude-on-pulmonary-vascular-function-and-exercise-capacity-in-mice-with-sickle-cell-anemia
#1
Scott K Ferguson, Katherine Redinius, Ayla Yalamanoglu, Julie W Harral, Jin Hyen Baek, David Pak, Zoe Loomis, Daniel Hassel, Paul Eigenberger, Eva Grayck, Rachelle Nuss, Kathryn Hassell, Kurt R Stenmark, Paul W Buehler, David C Irwin
KEY POINTS SUMMARY: Sickle cell disease (SCD) results in cardiopulmonary dysfunction, which may be exacerbated by prolonged exposure to environmental hypoxia. It is currently unknown if exposure to mild and moderate altitude exacerbates SCD associated cardiopulmonary and systemic complications. Three months of exposure to mild (1609 meters) and moderate (2438) altitude increased rates of hemolysis and right ventricular systolic pressures in mice with SCD when compared to healthy wild-type cohorts and SCD mice at sea level...
June 21, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29929637/implications-of-concomitant-tricuspid-regurgitation-in-patients-undergoing-transcatheter-aortic-valve-replacement-for-degenerated-surgical-aortic-bioprosthesis-insights-from-the-partner-2-aortic-valve-in-valve-registry
#2
Janarthanan Sathananthan, Dale J Murdoch, Brian R Lindman, Alan Zajarias, Wael A Jaber, Paul Cremer, David Wood, Robert Moss, Anson Cheung, Jian Ye, Rebecca T Hahn, Aaron Crowley, Martin B Leon, Michael J Mack, John G Webb
OBJECTIVES: The aim of this study was to assess the implications of concomitant tricuspid regurgitation (TR) in patients undergoing valve-in-valve (VIV) transcatheter aortic valve replacement. BACKGROUND: Patients undergoing VIV transcatheter aortic valve replacement with concomitant TR may have worse outcomes, and optimal management remains undetermined. METHODS: The multicenter PARTNER 2 (Placement of Aortic Transcatheter Valves) VIV trial enrolled patients with symptomatic degenerated surgical aortic bioprostheses who were at high risk for reoperation...
June 25, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29929635/combined-mitral-and-tricuspid-versus-isolated-mitral-valve-transcatheter-edge-to-edge-repair-in-patients-with-symptomatic-valve-regurgitation-at-high-surgical-risk
#3
Christian Besler, Stephan Blazek, Karl-Philipp Rommel, Thilo Noack, Maximilian von Roeder, Christian Luecke, Joerg Seeburger, Joerg Ender, Michael A Borger, Axel Linke, Matthias Gutberlet, Holger Thiele, Philipp Lurz
OBJECTIVES: The present study aimed to test the clinical benefit of combined transcatheter mitral plus tricuspid valve edge-to-edge repair (TMTVR) as compared with transcatheter mitral valve edge-to-edge repair (TMVR) alone in patients with both significant mitral (MR) and tricuspid regurgitation (TR) at high surgical risk. BACKGROUND: A growing number of patients with severe MR at increased surgical risk are treated by transcatheter techniques. Evidence suggests that residual TR remains a predictor of adverse outcome in these patients...
June 25, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29928790/targeted-ablation-of-cardiac-sympathetic-neurons-attenuates-adverse-post-infarction-remodeling-and-left-ventricle-dysfunction
#4
Liang Xiong, Yu Liu, Mingmin Zhou, Guangji Wang, Dajun Quan, Wei Shuai, Caijie Shen, Bin Kong, Congxin Huang, He Huang
NEW FINDINGS: What is the central question of this study? In this study, we investigated whether targeted ablation of cardiac sympathetic neurons (TACSN) could suppress myocardial infarction-induced adverse cardiac remodeling and left ventricle dysfunction. What is the main finding and its importance? TACSN significantly alleviated sympathetic remodeling and neuroendocrine activation, attenuated cardiac hypertrophy and fibrosis, and improved the left ventricular function. Thus, TACSN may have a beneficial effect on adverse post-infarction remodeling and left ventricle dysfunction...
June 21, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29928010/association-between-right-ventricle-two-and-three-dimensional-echocardiography-and-exercise-capacity-in-patients-with-reduced-left-ventricular-ejection-fraction
#5
Aleksandra Sljivic, Milena Pavlovic Kleut, Zoran Bukumiric, Vera Celic
INTRODUCTION: Echocardiography represents the most commonly performed noninvasive cardiac imaging test for patients with heart failure (HF). The aim of this study was to assess the relationship between exercise capacity parameters (peak oxygen consumption (VO2) and the minute ventilation-carbon dioxide production relationship (VE/VCO2)), two-dimensional speckle-tracking echocardiography (2D-STE) and three-dimensional echocardiography (3DE) imaging of right ventricular (RV) function in HF patients with reduced ejection fraction (EF)...
2018: PloS One
https://www.readbyqxmd.com/read/29926157/the-effect-of-desferrioxamine-chelation-versus-no-therapy-in-patients-with-non-transfusion-dependent-thalassaemia-a-multicenter-prospective-comparison-from-the-miot-network
#6
Paolo Ricchi, Antonella Meloni, Laura Pistoia, Anna Spasiano, Alessandra Spiga, Massimo Allò, Maria Rita Gamberini, Roberto Lisi, Saveria Campisi, Angelo Peluso, Massimiliano Missere, Stefania Renne, Maurizio Mangione, Vincenzo Positano, Alessia Pepe
We prospectively assessed by magnetic resonance imaging (MRI) the advantages of desferrioxamine (DFO) with respect to the absence of chelation therapy in non transfusion-dependent thalassaemia (NTDT) patients. We considered 18 patients non-chelated and 33 patients who received DFO alone between the two MRI scans. Iron overload was assessed by the T2* technique. Biventricular function parameters were quantified by cine sequences. No patient treated with DFO had cardiac iron. At baseline, only one non-chelated patient showed a pathological heart T2* value (< 20 ms) and he recovered at the follow-up...
June 21, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29925155/-clinical-features-of-post-splenectomy-pulmonary-hypertension-and-effects-of-its-target-therapy
#7
L Huang, T Yang, W Li, X T Wang, C M Xiong, X H Ni, Q Gu, J G He
Objective: To analyze the clinical features of post-splenectomy pulmonary hypertension and effects of its target therapy, and improve the diagnosis and treatment of the disease. Methods: Clinical data of 18 patients with post-splenectomy pulmonary hypertension admitted to Fuwai Hospital from October 2006 to March 2017 were systematically reviewed and analyzed. Results: Among the 18 patients with a mean age of (41±11) years old, 11 were women and 7 were men. The interval between splenectomy and the diagnosis of pulmonary hypertension was (11±6) years...
June 12, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29920539/clinical-phenotypes-and-outcomes-of-pulmonary-hypertension-due-to-left-heart-disease-role-of-the-pre-capillary-component
#8
Sergio Caravita, Andrea Faini, Sandy Carolino D'Araujo, Céline Dewachter, Laura Chomette, Antoine Bondue, Robert Naeije, Gianfranco Parati, Jean-Luc Vachiéry
BACKGROUND: In pulmonary hypertension (PH), both wedge pressure elevation (PAWP) and a precapillary component may affect right ventricular (RV) afterload. These changes may contribute to RV failure and prognosis. We aimed at describing the different haemodynamic phenotypes of patients with PH due to left heart disease (LHD) and at characterizing the impact of pulmonary haemodynamics on RV function and outcome PH-LHD. METHODS: Patients with PH-LHD were compared with treatment-naïve idiopathic/heritable pulmonary arterial hypertension (PAH, n = 35)...
2018: PloS One
https://www.readbyqxmd.com/read/29916179/changes-in-the-activity-of-some-metabolic-enzymes-in-the-heart-of-shr-rat-incurred-by-transgenic-expression-of-cd36
#9
Dmitry Manakov, David Kolar, Jitka Zurmanova, Michal Pravenec, Jiri Novotny
Hypertension, dyslipidemia, and insulin resistance in the spontaneously hypertensive rat (SHR) can be alleviated by rescuing CD36 fatty acid translocase. The present study investigated whether transgenic rescue of CD36 in SHR could affect mitochondrial function and activity of selected metabolic enzymes in the heart. These analyses were conducted on ventricular preparations derived from SHR and from transgenic strain SHR-Cd36 that expresses a functional wild-type CD36. Our respirometric measurements revealed that mitochondria isolated from the left ventricles exhibited two times higher respiratory activity than those isolated from the right ventricles...
June 18, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29915644/right-ventricular-dysplasia-management-and-treatment-in-light-of-current-evidence
#10
REVIEW
Amr Idris, Syed Raza Shah, Ki Park
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare cardiovascular disease that predisposes to ventricular arrhythmias potentially leading to sudden cardiac death (SCD). ARVC varies considerably with multiple clinical presentations, ranging from no symptoms to cardiac arrhythmias to SCD. ARVC prevalence is not well known, but the estimated prevalence in the general population is 1:5000. Diagnosis of ARVC can be made by using the Revised European Society of Cardiology criteria for ARVC that includes ventricular structural and functional changes, ECG abnormalities, arrhythmias, family and genetic factors...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29915098/primary-myocardial-fibrosis-as-an-alternative-phenotype-pathway-of-inherited-cardiac-structural-disorders
#11
M Juhani Junttila, Lauri Holmström, Katri Pylkäs, Tuomo Mantere, Kari Kaikkonen, Katja Porvari, Marja-Leena Kortelainen, Lasse Pakanen, Risto Kerkelä, Robert J Myerburg, Heikki V Huikuri
BACKGROUND: Myocardial fibrosis is a common postmortem finding among young individuals with sudden cardiac death. Because there is no known single cause, we tested the hypothesis that some cases of myocardial fibrosis in the absence of identifiable causes (primary myocardial fibrosis [PMF]) are associated with genetic variants. METHODS: Tissue was obtained at autopsy from 4031 consecutive individuals with sudden cardiac death in Northern Finland, among whom PMF was the only structural finding in 145 subjects with sudden cardiac death...
June 19, 2018: Circulation
https://www.readbyqxmd.com/read/29914554/prehospital-point-of-care-emergency-ultrasound-a-cohort-study
#12
Maximilian Scharonow, Christian Weilbach
BACKGROUND: In the prehospital situation, the diagnostic armamentarium available to the rescue physician is limited. Emergency ultrasound has proven to be a useful diagnostic tool, providing crucial information for the management of critically ill and injured patients. The proportion of performed ultrasound scans in all patients attended to by the rescue service team, the quality of the findings and the ultrasound-related changes in management approach and patient transport were evaluated...
June 18, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29914536/very-late-presentation-of-anomalous-origin-of-the-left-coronary-artery-from-the-pulmonary-artery-case-report
#13
Pairoj Chattranukulchai, Jule Namchaisiri, Monravee Tumkosit, Sarinya Puwanant, Yongkasem Vorasettakarnkij, Suphot Srimahachota, Smonporn Boonyaratavej
BACKGROUND: Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital coronary anomaly. The enlarged right coronary artery provides retrograde collaterals to supply the left ventricle then preferentially directs into the lower pressure pulmonary artery system causing coronary steal phenomenon. Few patients who survive through adulthood without surgery must have abundant, well-formed functioning collaterals with adequate perfusion of the left ventricle...
June 18, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29914291/the-path-to-surgery-in-carcinoid-heart-disease-a-retrospective-study-and-a-multidisciplinary-proposal-of-a-new-algorithm
#14
Philippe Mortelmans, Marie-Christine Herregods, Filip Rega, Philippe Timmermans
BACKGROUND: Development of carcinoid heart disease (CHD) is the major negative prognostic factor in patients with the carcinoid syndrome. The only effective treatment is valve replacement. However, the selection of candidates and determination of optimal timing remain unclear. Considerable variability in local screening and treatment strategies exist. METHODS: In this single-centre study, we retrospectively analysed the diagnostic process and outcome of all CHD patients who underwent valve surgery between 2000 and 2016...
June 18, 2018: Acta Cardiologica
https://www.readbyqxmd.com/read/29913136/mmp-2-and-mmp-9-contribute-to-the-angiogenic-effect-produced-by-hypoxia-15-hete-in-pulmonary-endothelial-cells
#15
Ying Liu, Hongyue Zhang, Lixin Yan, Wei Du, Min Zhang, He Chen, Lixin Zhang, Guangqun Li, Jijin Li, Yinchu Dong, Daling Zhu
Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are the predominant gelatinases in the developing lung. Studies have shown that the expression of MMP-2 and MMP-9 is upregulated in hypoxic fibroblasts, 15-hydroxyeicosatetraenoic acid (15-HETE) regulated fibroblasts migration via modulating MMP-2 or MMP-9, and that hypoxia/15-HETE is a predominant contributor to the development of pulmonary arterial hypertension (PAH) through increased angiogenesis. However, the roles of MMP-2 and MMP-9 in pulmonary arterial endothelial cells (PAECs) angiogenesis as well as the molecular mechanism of hypoxia-regulated MMP-2 and MMP-9 expression have not been identified...
June 15, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29912990/peptide-conjugated-phosphodiamidate-oligomer-mediated-exon-skipping-has-benefits-for-cardiac-function-in-mdx-and-cmah-mdx-mouse-models-of-duchenne-muscular-dystrophy
#16
Alison M Blain, Elizabeth Greally, Graham McClorey, Raquel Manzano, Corinne A Betts, Caroline Godfrey, Liz O'Donovan, Thibault Coursindel, Mike J Gait, Matthew J Wood, Guy A MacGowan, Volker W Straub
Cardiac failure is a major cause of mortality in patients with Duchenne muscular dystrophy (DMD). Antisense-mediated exon skipping has the ability to correct out-of-frame mutations in DMD to produce truncated but functional dystrophin. Traditional antisense approaches have however been limited by their poor uptake into cardiac muscle. The addition of cell-penetrating peptides to antisense molecules has increased their potency and improved their uptake into all muscles, including the heart. We have investigated the efficacy of the Peptide-conjugated phosphodiamidate morpholino oligomer (P-PMO) Pip6a-PMO, for restoration of cardiac dystrophin and functional rescue in DMD mice- the mdx mouse and the less well characterised Cmah-/-mdx mouse (which carry a human-like mutation in the mouse Cmah gene as well as a mutation in DMD)...
2018: PloS One
https://www.readbyqxmd.com/read/29912741/predictors-of-persistent-tricuspid-regurgitation-after-transcatheter-aortic-valve-replacement-in-patients-with-baseline-tricuspid-regurgitation
#17
Berhane Worku, Marie-Therese Valovska, Adham Elmously, Polydoros Kampaktsis, Catherine Castillo, Shing-Chiu Wong, Arash Salemi
OBJECTIVE: This study sought to analyze outcomes in patients with moderate-severe tricuspid regurgitation (TR) undergoing transcatheter aortic valve replacement (TAVR). The consequences of uncorrected significant TR in patients undergoing TAVR remain undefined. METHODS: Between 2009 and 2014, 369 patients underwent TAVR at our institution, and 58 of these had baseline moderate-severe TR. Preoperative, 30-day, and 1-year transthoracic echocardiograms were analyzed...
June 15, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29912349/two-stage-arterial-switch-for-late-presenting-transposition-of-the-great-arteries
#18
Tornike Sologashvili, Laure Wannaz, Maurice Beghetti, Yacine Aggoun, René Prêtre, Patrick O Myers
OBJECTIVES: Ventricular retraining and arterial switch have been described in late-presenting transposition of the great arteries (TGA) in older infants who were unable to undergo neonatal arterial switch operation (ASO) and late survivors of atrial switch with systemic right ventricular dysfunction. There are little data available on patients presenting between these 2 groups. This study aims to review the early and mid-term outcomes of the management of late-presenting TGA with an unprepared left ventricle (LV) by a 2-stage arterial switch...
April 17, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29911008/hemodynamic-effects-of-noninvasive-positive-pressure-ventilation-assessed-using-transthoracic-echocardiography
#19
Shek Yin Au, Cheuk Ling Lau, Ka King Chen, Adrian Piers Cheong, Ying Ting Tong, Lip Kiong Chan
Aims: The aim of this study is to measure the effect of positive-pressure ventilation on heart chamber dimensions, left ventricular (LV) systolic function, LV diastolic function, right ventricular (RV) systolic function, and RV pressure using transthoracic echocardiography. Settings and Design: This is a prospective study in a single secondary health-care center. Materials and Methods: A total of 107 patients with obstructive sleep apnea on continuous positive airway pressure (CPAP) therapy were recruited as participants between April and September 2016...
April 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29911007/elevated-mean-pulmonary-artery-pressure-and-right-ventricular-dysfunction-in-children-with-chronic-kidney-disease
#20
Igoche D Peter, Mustafa O Asani, Ibrahim Aliyu, Patience N Obiagwu
Background: Elevated mean pulmonary artery pressure (mPAP) and right heart failure increase mortality in patients with chronic kidney disease (CKD). Objectives: The objective of this study is to determine the prevalence of elevated mPAP in children with CKD compared with matched controls and to ascertain the relationship between elevated mPAP with right ventricular dysfunction and history of hemodialysis. Materials and Methods: A cross-sectional comparative study of mPAP and tricuspid annular plane systolic excursion of 21 children with CKD and age- and sex-matched controls asymptomatic for cardiac disease was conducted...
April 2018: Journal of Cardiovascular Echography
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