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https://www.readbyqxmd.com/read/29773273/childhood-systemic-vasculitis
#1
REVIEW
Erdal Sag, Ezgi Deniz Batu, Seza Ozen
Vasculitides are characterized by inflammation of the vessel wall. Most of the vasculitides tend to occur in vessels of a specific size and certain target organs. In this review, we discuss each specific childhood vasculitis according to the latest Chapel Hill Consensus Conference 2012 nomenclature system and the Ankara 2008 classification criteria. We have also reviewed the clinical and laboratory characteristics and the recent treatment recommendations for the vasculitides we encounter in children.
August 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29766256/monogenic-systemic-lupus-erythematosus-insights-in-pathophysiology
#2
REVIEW
Ezgi Deniz Batu
Systemic lupus erythematosus (SLE) is a complex disease with different genetic, immunologic, and environmental factors contributing to the pathogenesis. Monogenic SLE could help us understand the main phases of immune dysregulation in SLE. The aim of this review is to summarize the current knowledge on monogenic SLE with the implications of the respective genes on disease pathogenesis. A comprehensive literature search on monogenic SLE was conducted utilizing the Cochrane Library and MEDLINE/PubMed databases...
May 15, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29764793/evaluation-of-the-ovarian-reserve-in-adolescents-with-hashimoto-s-thyroiditis-using-serum-anti-m%C3%A3-llerian-hormone-levels
#3
Ezgi Özalp Akın, Zehra Aycan
OBJECTIVE: This study aims to evaluate the ovarian reserve of the adolescent girls with Hashimoto's thyroiditis (HT) with serum anti-müllerian hormone (AMH) levels and compare to healthy adolescents. It is hypothesized that HT decreases ovarian reserve and AMH levels are lower in the HT group. METHOD: Thirty HT patients aged between 10-18 years and 30 healthy girls as the control group are enrolled in this cross-sectional study. The mean serum AMH levels of the groups are compared using the Mann-Whitney U test...
May 16, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29746438/hemophagocytic-lymphohistiocytosis-associated-with-visceral-leishmaniasis
#4
Nihal Özdemir, Başak Koç, Esra Arslantaş, Işik Odaman Al, Çiğdem Kelleci, Ezgi Pasli Uysalol, Cengiz Bayram, Ali Ayçiçek
This is the report of a 2-year-old boy who presented with fever, cytopenia, and splenomegaly. The patient was diagnosed with hemophagocytic lymphohistiocytosis (HLH) and treated with HLH-2004 protocol. Repeated bone marrow aspiration showed amastigotes on follow-up. In endemic countries, visceral leishmaniasis should be considered in the differential diagnosis to avoid chemotherapy toxicity.
May 9, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29725622/somatic-gnaq-mutation-in-the-forme-fruste-of-sturge-weber-syndrome
#5
Michael S Hildebrand, A Simon Harvey, Stephen Malone, John A Damiano, Hongdo Do, Zimeng Ye, Lara McQuillan, Wirginia Maixner, Renate Kalnins, Bernadette Nolan, Martin Wood, Ezgi Ozturk, Nigel C Jones, Greta Gillies, Kate Pope, Paul J Lockhart, Alexander Dobrovic, Richard J Leventer, Ingrid E Scheffer, Samuel F Berkovic
Objective: To determine whether the GNAQ R183Q mutation is present in the forme fruste cases of Sturge-Weber syndrome (SWS) to establish a definitive molecular diagnosis. Methods: We used sensitive droplet digital PCR (ddPCR) to detect and quantify the GNAQ mutation in tissues from epilepsy surgery in 4 patients with leptomeningeal angiomatosis; none had ocular or cutaneous manifestations. Results: Low levels of the GNAQ mutation were detected in the brain tissue of all 4 cases-ranging from 0...
June 2018: Neurology. Genetics
https://www.readbyqxmd.com/read/29706112/ventriculoperitoneal-shunt-infections-and-re-infections-in-children-a-multicentre-retrospective-study
#6
Nurhayat Yakut, Ahmet Soysal, Eda Kepenekli Kadayifci, Nazan Dalgic, Dilek Yılmaz Ciftdogan, Ayse Karaaslan, Gulsen Akkoc, Sevliya Ocal Demir, Eren Cagan, Ezgi Celikboya, Ali Kanik, Adnan Dagcinar, Adem Yilmaz, Fusun Ozer, Mahmut Camlar, Ozden Turel, Mustafa Bakir
PURPOSE: Ventriculoperitoneal shunt (VPS) is the most common treatment modality for hydrocephalus. However, VPS infection is a common and serious complication with high rates of mortality and morbidity. The objective of this study was to investigate causative agents and the management of VPS infections and to identify risk factors for re-infection in children. MATERIALS AND METHODS: Retrospective, multicentre study on patients with VPS infection at paediatric and neurosurgery departments in four tertiary medical centres in Turkey between January 2011 and September 2014...
April 28, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29697420/poxvirus-induced-vascular-angiogenesis-mimicking-pyogenic-granuloma
#7
Zehra Aşiran Serdar, Şirin Yaşar, Cuyan Demirkesen, Ezgi Aktaş Karabay
The orf virus, a member of poxvirus family, is a zoonotic parapoxvirus endemic in many countries, mostly seen among sheep, goats, oxen, and may be transmitted to humans. Orf virus infections may induce ulceration, papulonodular, pustular, or ecthyma lesions in the skin. Rarely, orf virus provokes extensive vasculoendothelial proliferation by encoding an apparent homolog of the mammalian vascular endothelial growth factor family of molecules. The vascular endothelial growth factor-like viral gene product is expressed early during infection and could be responsible for the induction of endothelial proliferation...
April 24, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29680240/peptide-derivatives-of-erythropoietin-in-the-treatment-of-neuroinflammation-and-neurodegeneration
#8
Ilkcan Ercan, Kemal Ugur Tufekci, Ezgi Karaca, Sermin Genc, Kursad Genc
During the past 35 years, recombinant DNA technology has allowed the production of a wide range of hematopoietic and neurotrophic growth factors including erythropoietin (EPO). These have emerged as promising protein drugs in various human diseases. Accumulated evidences have recently demonstrated the neuroprotective effect of EPO in preclinical models of acute and chronic degenerative disorders. Nevertheless, tissue protective effect of EPO could not be translated to the clinical trials because of common lethal thromboembolic events, erythropoiesis and hypertension...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29675612/complement-receptor-1-gene-cr1-intragenic-duplication-and-risk-of-alzheimer-s-disease
#9
Ezgi Kucukkilic, Keeley Brookes, Imelda Barber, Tamar Guetta-Baranes, Kevin Morgan, Edward J Hollox
Single nucleotide variants (SNVs) within and surrounding the complement receptor 1 (CR1) gene show some of the strongest genome-wide association signals with late-onset Alzheimer's disease. Some studies have suggested that this association signal is due to a duplication allele (CR1-B) of a low copy repeat (LCR) within the CR1 gene, which increases the number of complement C3b/C4b-binding sites in the mature receptor. In this study, we develop a triplex paralogue ratio test assay for CR1 LCR copy number allowing large numbers of samples to be typed with a limited amount of DNA...
April 19, 2018: Human Genetics
https://www.readbyqxmd.com/read/29672086/self-compassion-matters-the-relationships-between-perceived-social-support-self-compassion-and-subjective-well-being-among-lgb-individuals-in-turkey
#10
Ezgi Toplu-Demirtaş, Gülşah Kemer, Amber L Pope, Jeffry L Moe
Research on the well-being of lesbian, gay, and bisexual (LGB) people has predominately focused on Western (-ized) societies where individualism, and not collectivism, is emphasized. In the present study, we utilized a mediator model via Structural Equation Modeling (SEM) to examine the relationships between self-compassion (i.e., self-kindness, common humanity, and mindfulness), perceived social support (i.e., family, friends, and significant others), and subjective well-being (i.e., life satisfaction, positive affect, and negative affect) in a sample of LGB-identified individuals living in Turkey, a traditionally collectivistic culture (Hofstede, 2001)...
April 2018: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/29663651/engineered-natural-and-synthetic-polymer-surfaces-induce-nuclear-deformation-in-osteosarcoma-cells
#11
Ezgi Antmen, Menekse Ermis, Utkan Demirci, Vasif Hasirci
Cell-substrate interactions involve constant probing of microenvironment by cells. One of the responses of cells to environmental cues is to change the conformation of their cytoplasm and nucleus. We hypothesized that surface chemistry and topography could be engineered to make these differences significant enough. When designing the substrates that would accentuate these differences, we prepared surfaces carrying cell adhesive biological cues arranged in specific patterns. Collagen type I and poly(lactic acid-co-glycolic acid) (PLGA) were used to represent substrates with biological cues and those without, and these materials were decorated with four square prism micropillars with different dimensions...
April 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29661717/primary-breast-carcinomas-with-neuroendocrine-features-clinicopathological-features-and-analysis-of-tumor-growth-patterns-in-36-cases
#12
Canan Kelten Talu, Cem Leblebici, Tulin Kilicaslan Ozturk, Ezgi Hacihasanoglu, Sevim Baykal Koca, Zuhal Gucin
Primary breast carcinoma with neuroendocrine features (NEBC) is an uncommon tumor. In the classification of WHO 2012, these tumors were categorized as: 1- neuroendocrine tumor, well-differentiated; 2- neuroendocrine carcinoma, poorly differentiated/small cell carcinoma; and 3- invasive breast carcinoma with neuroendocrine differentiation. In this study, we reviewed NEBC except poorly differentiated/small cell carcinoma variant in order to define the morphological growth patterns and cytonuclear details of these tumors...
April 4, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29651847/labeling-carboxyl-groups-of-surface-exposed-proteins-provides-an-orthogonal-approach-for-cell-surface-isolation
#13
Nazlı Ezgi Özkan Küçük, Erdem Şanal, Edwin Tan, Timothy Mitchison, Nurhan Özlü
Quantitative profiling of cell surface proteins is critically important for the understanding of cell-cell communication, signaling, tissue development and homeostasis. Traditional proteomics methods are challenging for cell surface proteins due to their hydrophobic nature and low abundance, necessitating alternative methods to efficiently identify and quantify this protein group. Here, we established carboxyl reactive biotinylation for selective and efficient biotinylation and isolation of surface-exposed proteins of living cells...
April 13, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29621065/a-rare-case-of-pediatric-bone-precursor-b-cell-lymphoma-presenting-with-multiple-fractures
#14
Nihal Özdemir, Başak Koç, Ezgi P Uysalol, Cengiz Bayram, Işik O Al, Rengin Şiraneci, Gülçin Yeğen, Ahmet Salduz
No abstract text is available yet for this article.
April 4, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29609676/turkish-version-of-the-multidimensional-measure-of-emotional-abuse-preliminary-psychometrics-in-college-students
#15
Ezgi Toplu Demirtaş, Zeynep Hatipoğlu Sümer, Christopher M Murphy
The aim of the current study was to investigate the basic psychometrics of the Multidimensional Measure of Emotional Abuse (MMEA; Murphy & Hoover, 1999) in a Turkish sample. Two hundred and fifty-four college students participated and completed the Turkish version of the MMEA (MMEA-TR) along with the Physical Assault of Conflict Tactics Scale-Revised, Experiences in Close Relationships Inventory, Relationship Assessment Scale, and Social Desirability Questionnaire. Confirmatory factor analysis supported the four-factor structure of the MMEA-TR for both victimization and perpetration reports...
April 1, 2018: Violence and Victims
https://www.readbyqxmd.com/read/29594674/child-art-psychotherapy-in-camhs-in-ireland-a-parent-satisfaction-study
#16
Ezgi Tanıl, Aynur Coşkunlu, Aisling Mulligan
OBJECTIVES: We aimed to evaluate parent satisfaction with the Vasarhelyi method of Child Art Psychotherapy offered at two Child and Adolescent Mental Health teams by postal survey using the Client Satisfaction Questionnaire, and by performing a qualitative interview. METHODS: Parents of 29 children who attended Child Art Psychotherapy over the previous 4 years were invited to participate-they were sent the Client Satisfaction Questionnaire and invited to attend for an interview about Child Art Psychotherapy...
March 29, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29582676/factors-impacting-the-performance-characteristics-of-bile-duct-brushings-a-clinico-cytopathologic-analysis-of-253-patients
#17
Ezgi Hacihasanoglu, Bahar Memis, Burcin Pehlivanoglu, Vaidehi Avadhani, Alexa A Freedman, Michael M Goodman, N Volkan Adsay, Michelle D Reid
CONTEXT: - Literature on factors impacting bile duct brushings (BDBs) performance characteristics remain limited. OBJECTIVE: - To capture the current state of daily practice with BDB sign-out. DESIGN: - Two hundred fifty-three of 444 BDBs signed out by more than 7 cytopathologists, with histopathologic and/or clinical follow-up of at least 18 months, were examined. RESULTS: - One hundred thirty-five of 253 BDBs (53%) had histologically confirmed malignancies, 22 (9%) had cancer-related deaths, and 96 (38%) were benign...
March 27, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29562920/the-safety-of-live-attenuated-vaccines-in-patients-using-il-1-or-il-6-blockade-an-international-survey
#18
Jerold Jeyaratnam, Nienke M Ter Haar, Helen J Lachmann, Ozgur Kasapcopur, Amanda K Ombrello, Donato Rigante, Fatma Dedeoglu, Ezgi H Baris, Sebastiaan J Vastert, Nico M Wulffraat, Joost Frenkel
BACKGROUND: Withholding live-attenuated vaccines in patients using interleukin (IL)-1 or IL-6 blocking agents is recommended by guidelines for both pediatric and adult rheumatic diseases, since there is a risk of infection in an immune suppressed host. However, this has never been studied. This retrospective, multicenter survey aimed to evaluate the safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade. METHODS: We contacted physicians involved in the treatment of autoinflammatory diseases to investigate potential cases...
March 21, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29554166/asymptomatic-erythematous-plaques-on-the-scalp-and-face
#19
Ezgi Ozkur, Mehmet S Gurel, Ayşe Ek Aksu, Aslı Vt Erdemir, Cem Leblebici
No abstract text is available yet for this article.
February 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29551265/transposase-dna-complex-structures-reveal-mechanisms-for-conjugative-transposition-of-antibiotic-resistance
#20
Anna Rubio-Cosials, Eike C Schulz, Lotte Lambertsen, Georgy Smyshlyaev, Carlos Rojas-Cordova, Kristoffer Forslund, Ezgi Karaca, Aleksandra Bebel, Peer Bork, Orsolya Barabas
Conjugative transposition drives the emergence of multidrug resistance in diverse bacterial pathogens, yet the mechanisms are poorly characterized. The Tn1549 conjugative transposon propagates resistance to the antibiotic vancomycin used for severe drug-resistant infections. Here, we present four high-resolution structures of the conserved Y-transposase of Tn1549 complexed with circular transposon DNA intermediates. The structures reveal individual transposition steps and explain how specific DNA distortion and cleavage mechanisms enable DNA strand exchange with an absolute minimum homology requirement...
March 2, 2018: Cell
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