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https://www.readbyqxmd.com/read/28626961/comparing-polyarteritis-nodosa-in-children-and-adults-a-single-center-study
#1
Abdulsamet Erden, Ezgi D Batu, Hafize E Sönmez, Alper Sarı, Berkan Armagan, Zehra S Arıcı, Emre Bilgin, Umut Kalyoncu, Ömer Karadağ, Yelda Bilginer, Ali Ihsan Ertenli, Seza Özen
OBJECTIVE: Polyarteritis nodosa (PAN) is a necrotizing vasculitis of medium/small arteries. We aimed to examine the characteristics of adult- and childhood-onset PAN. METHODS: Fifteen pediatric (˂ 18 years) and 22 adult PAN patients who fulfilled the Ankara 2008 and American College of Rheumatology 1990 criteria, respectively, were included in the study. RESULTS: Five children had cutaneous and all the rest of the patients had systemic PAN...
June 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28607584/a-combined-ulbp2-and-sema5a-expression-signature-as-a-prognostic-and-predictive-biomarker-for-colon-cancer
#2
Secil Demirkol, Ismail Gomceli, Murat Isbilen, Baris Emre Dayanc, Mesut Tez, Erdal Birol Bostanci, Nesrin Turhan, Musa Akoglu, Ezgi Ozyerli, Sevi Durdu, Ozlen Konu, Aviram Nissan, Mithat Gonen, Ali Osmay Gure
Background: Prognostic biomarkers for cancer have the power to change the course of disease if they add value beyond known prognostic factors, if they can help shape treatment protocols, and if they are reliable. The aim of this study was to identify such biomarkers for colon cancer and to understand the molecular mechanisms leading to prognostic stratifications based on these biomarkers. Methods and Findings: We used an in house R based script (SSAT) for the in silico discovery of stage-independent prognostic biomarkers using two cohorts, GSE17536 and GSE17537, that include 177 and 55 colon cancer patients, respectively...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28604465/brachial-plexus-injury-associated-with-subclavian-vein-cannulation-a-case-report
#3
Ezgi Gozubuyuk, Mehmet I Buget, Turgut Akgul, Demet Altun, Suleyman Kuçukay
We documented brachial plexus injury by electromyography and magnetic resonance imaging secondary to needle sticks for central line insertion. This type of complication is rare in the literature, as few case reports exist. Brachial plexus injury can happen because of anatomic variations. Nevertheless, multiple attempts or introducer needle rotations should be avoided during subclavian vein catheterization. Pain that emerges in the ipsilateral arm after subclavian catheter placement should be taken into serious consideration...
June 8, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28602636/extensive-phenotyping-of-two-arx-polyalanine-expansion-mutation-mouse-models-that-span-clinical-spectrum-of-intellectual-disability-and-epilepsy
#4
Matilda R Jackson, Kristie Lee, Tessa Mattiske, Emily J Jaehne, Ezgi Ozturk, Bernhard T Baune, Terence J O'Brien, Nigel Jones, Cheryl Shoubridge
The Aristaless-related homeobox gene (ARX) is a known intellectual disability (ID) gene that frequently presents with X-linked infantile spasm syndrome as a comorbidity. ID with epilepsy in children is a chronic and devastating disorder that has poor treatment options and disease outcomes. To gain a better understanding of the role that mutations in ARX play in ID and epilepsy, we investigate ARX patient mutations modelled in mice. Over half of all ARX mutations result from expansions of the first two polyalanine (PA1 and PA2 respectively) tracts...
June 8, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28593113/the-added-value-of-diffusion-magnetic-resonance-imaging-in-the-diagnosis-and-posttreatment-evaluation-of-skull-base-chordomas
#5
Ezgi Guler, Burce Ozgen, Melike Mut, Figen Soylemezoglu, Kader Karli Oguz
Objectives  To determine the use of diffusion-weighted imaging (DWI) in the pre- and posttreatment evaluation of skull base chordomas. Design  Retrospective study. Setting  Tertiary care university hospital. Participants  In total, 17 patients with histopathological diagnosis of chordoma who had magnetic resonance (MR) imaging and DWI were evaluated. Of them, 13 patients had posttreatment MR imaging including DWI. Main Outcome Measures  Three apparent diffusion coefficient (ADC) values were obtained from tumor, and an ADC value was measured from pons for the purpose of normalization...
June 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28584381/cutaneous-angiosarcoma-mimicking-panniculitis-in-the-lower-extremities
#6
Sumeyre Seda Ertekin, Ezgi Ozkur, Cem Leblebici, Mehmet Salih Gürel, Asli Vefa Turgut Erdemir
No abstract text is available yet for this article.
May 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28569243/cell-sheet-based-bioink-for-3d-bioprinting-applications
#7
Ezgi Bakirci, Burak Toprakhisar, Mehmet Zeybek, Gozde Ozaydin Ince, Bahattin Koc
In this research, a novel development of bioink from cell sheets is presented for scaffold free bioprinting applications. Poly(N-isopropylacrylamide) (PNIPAAm) coated surfaces were first prepared by using initiated Chemical Vapor Deposition (iCVD) method. Cell-sheets were then grown on these thermoresposnsive pNIPAAm coated surfaces and easily detached without disturbing delicate cell-extracellular matrix (ECM) and cell-cell interactions. The detached cells sheets were used to prepare cell sheet based bioink and bioprinted to form various shapes...
June 1, 2017: Biofabrication
https://www.readbyqxmd.com/read/28559631/effect-of-olive-leaf-extract-rich-in-oleuropein-on-the-quality-of-virgin-olive-oil
#8
Selin Şahin, Ezgi Sayım, Mehmet Bilgin
Effect of olive leaf extract rich in oleuropein on the quality of virgin olive oil was investigated. After extracting the dried and ground olive leaves with the assistance of homogenizer, the dried extract was partially dissolved into the oil to increase the oxidative stability of the oil. A face central composite design through response surface methodology was used to investigate the effects of enrichment conditions (extract content, time and mixing speed) on the responses, total phenolic content and oleuropein concentration of the enriched olive oil...
May 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28554462/treatment-of-class-ii-malocclusion-with-mandibular-skeletal-anchorage
#9
Ezgi Cakir, Siddik Malkoç, Mustafa Kirtay
INTRODUCTION: The aim of this case report was to present the dentofacial changes obtained with bone anchorage in a Class II patient with moderate to severe crowding. METHODS: A boy, aged 14.5 years, with a dolichofacial type, convex profile, and skeletal and dental Class II relationships was examined. After evaluation, functional treatment with bone anchorage and 4 first premolar extractions was decided as the treatment approach. Miniplates were placed on the buccal shelves of the mandibular third molars...
June 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28548456/proteomics-in-cell-division
#10
REVIEW
Zeynep Cansu Üretmen Kagıalı, Aydanur Şentürk, Nazlı Ezgi Özkan Küçük, Mohammed Haroon Qureshi, Nurhan Özlü
Cell division requires a coordinated action of the cell cycle machinery, cytoskeletal elements, chromosomes and membranes. Cell division studies have greatly benefitted from the mass spectrometry (MS)-based proteomic approaches for probing the biochemistry of highly dynamic complexes and their coordination with each other as a cell progresses into division. In this review, we first summarize a wide-range of proteomic studies that focus on the identification of sub-cellular components/protein complexes of the cell division machinery including kinetochores, mitotic spindle, midzone and centrosomes...
May 26, 2017: Proteomics
https://www.readbyqxmd.com/read/28535396/molecular-identification-of-viral-agents-associated-with-acute-conjunctivitis-a-prospective-controlled-study
#11
Emine Akçay, Ahmet Çarhan, Gözde Hondur, Zeliha Koçak Tufan, Necati Demir, Selçuk Kılıç, Ezgi Naz Ensari, Nagihan Uğurlu, Nurullah Çağıl
No abstract text is available yet for this article.
May 20, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28515430/a-microfluidic-chip-for-screening-individual-cancer-cells-via-eavesdropping-on-autophagy-inducing-crosstalk-in-the-stroma-niche
#12
Hacer Ezgi Karakas, Junyoung Kim, Juhee Park, Jung Min Oh, Yongjun Choi, Devrim Gozuacik, Yoon-Kyoung Cho
Autophagy is a cellular homeostatic mechanism where proteins and organelles are digested and recycled to provide an alternative source of building blocks and energy to cells. The role of autophagy in cancer microenvironment is still poorly understood. Here, we present a microfluidic system allowing monitoring of the crosstalk between single cells. We used this system to study how tumor cells induced autophagy in the stromal niche. Firstly, we could confirm that transforming growth factor β1 (TGFβ1) secreted from breast tumor cells is a paracrine mediator of tumor-stroma interaction leading to the activation of autophagy in the stroma component fibroblasts...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28505002/immunohistochemical-classification-of-ampullary-carcinomas-critical-reappraisal-fails-to-confirm-prognostic-relevance-for-recently-proposed-panels-and-highlights-muc5ac-as-a-strong-prognosticator
#13
Yue Xue, Michelle D Reid, Serdar Balci, Brian Quigley, Takashi Muraki, Bahar Memis, Jun Xia, Ezgi Hacihasanoglu, Gabriela Bedolla, Burcin Pehlivanoglu, Grace E Kim, Takuma Tajiri, Nobuyike Ohike, Ritu Aneja, Alyssa M Krasinskas, Volkan Adsay
Recently, immunohistochemistry-based classifications of ampullary carcinomas have been proposed (Ang and colleagues [PMID: 24832159]; Chang and colleagues [PMID: 23439753]). In this study, the prognostic value of Ang/Chang panel markers (CK20, MUC1, MUC2, CDX2) as well as other markers (CK7, MUC5AC, and MUC6) were tested on full-faced sections of 136 ampullary carcinoma resections with substantial (>5 mm) invasion. Immunohistochemistry was correlated with both histologic classification (intestinal [INT], pancreatobiliary [PB], or nontubular based on ≥3/5 observer agreement) and clinical outcome...
July 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28486226/role-of-albumin-in-growth-inhibition-in-hepatocellular-carcinoma
#14
Ezgi Bağırsakçı, Eren Şahin, Neşe Atabey, Esra Erdal, Vito Guerra, Brian I Carr
OBJECTIVE: Levels of serum albumin have recently emerged, together with C-reactive protein, as an important prognostic indicator for hepatocellular carcinoma (HCC). It has recently been reported that larger HCCs are associated with lower albumin levels. However, the albumin-mediated growth decrease has yet to be determined. METHODS: We examined a large HCC cohort and then by direct exposure of HCC cells in vitro, the relationship of albumin levels to HCC growth...
May 10, 2017: Oncology
https://www.readbyqxmd.com/read/28485700/disgust-and-anger-relate-to-different-aggressive-responses-to-moral-violations
#15
Catherine Molho, Joshua M Tybur, Ezgi Güler, Daniel Balliet, Wilhelm Hofmann
In response to the same moral violation, some people report experiencing anger, and others report feeling disgust. Do differences in emotional responses to moral violations reflect idiosyncratic differences in the communication of outrage, or do they reflect differences in motivational states? Whereas equivalence accounts suggest that anger and disgust are interchangeable expressions of condemnation, sociofunctional accounts suggest that they have distinct antecedents and consequences. We tested these accounts by investigating whether anger and disgust vary depending on the costs imposed by moral violations and whether they differentially correspond with aggressive tendencies...
May 2017: Psychological Science
https://www.readbyqxmd.com/read/28483235/basophil-activation-test-for-inhalant-allergens-in-pediatric-patients-with-allergic-rhinitis
#16
Ismail Ogulur, Ayca Kiykim, Safa Baris, Ahmet Ozen, Ezgi Gizem Yuce, Elif Karakoc-Aydiner
OBJECTIVE: Flow cytometric quantification of in vitro basophil activation can be quite performant and reliable tool to measure IgE-dependent allergen-specific responses in allergic patients. Current study aimed to evaluate the clinical relevance of basophil activation test (BAT) for the diagnosis of pediatric grass pollen and house dust mite (HDM) allergies. METHODS: Forty-seven patients suffering from allergic rhinitis with HDM and grass pollen co-sensitization with clinical history of allergic rhinitis and/or asthma and 15 non-allergic healthy subjects were enrolled...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28451540/determination-of-drug-compliance-of-hypertensive-individuals
#17
Ezgi Bağriaçik, Buket Çimen, Sağdiç Tağrık, Ümran Dal Yilmaz
No abstract text is available yet for this article.
January 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28450566/studies-of-a-next-generation-silicon-photomultiplier-based-time-of-flight-pet-ct-system
#18
David Fc Hsu, Ezgi Ilan, William T Peterson, Jorge Uribe, Mark Lubberink, Craig S Levin
This article presents system performance studies of the Discovery MI PET/CT system, a new time-of-flight (TOF) system based on silicon photomultipliers. System performance and clinical imaging comparisons were made between this next-generation system and other commercially available PET/CT and PET/MR systems, as well as between different reconstruction algorithms. Methods: Spatial resolution, sensitivity, NECR, scatter fraction, count rate accuracy, and image quality were characterized with the NEMA NU-2 2012 standards...
April 27, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28443819/a-rare-late-complication-of-port-catheter-implantation-embolization-of-the-catheter
#19
Işık Odaman Al, Cengiz Bayram, Gizem Ersoy, Kazım Öztarhan, Alper Güzeltaş, Taner Kasar, Ezgi Uysalol, Başak Koç, Ali Ayçiçek, Nihal Özdemir
No abstract text is available yet for this article.
April 26, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/28443597/a-different-slc2a1-gene-mutation-in-glut-1-deficiency-syndrome-c-734a-c
#20
Rüya Çolak, Senem Alkan Özdemir, Ezgi Yangın Ergon, Mehtap Kağnıcı, Şebnem Çalkavur
BACKGROUND: Neonatal seizures can be the first symptom of the inborn errors of metabolism. Glucose transporter type 1 deficiency syndrome (GLUT1DS) is the result of impaired glucose transport into the brain. GLUT1DS patient presents with infantile seizures with resistant to traditional seizure medications, developmental delay, acquired microcephaly, spasticity and ataxia. CASE REPORT: Here, we report a rare case of Glucose transporter type 1 deficiency syndrome caused by a different pathogenic variant in a 10-day-old neonate who presented with intractable seizures and respiratory arrest...
April 13, 2017: Balkan Medical Journal
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