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https://www.readbyqxmd.com/read/28816607/investigation-of-a-green-process-for-the-polymerization-of-catechin
#1
Ayşe Ezgi Ünlü, Brinda Prasad, Kishan Anavekar, Paul Bubenheim, Andreas Liese
Flavonoids are polyphenolic secondary plant metabolites which possess antioxidant and anti-inflammatory properties. Besides, they have been shown to exhibit increased antioxidant properties in their polymerized form. Catechins are one of the attractive class of flavonoids which belong to the group of flavan-3-ols. Polymerization of catechins have been investigated in numerous studies indicating the requirement of certain amount of organic solvent to provide the solubility of the monomer. However, many research projects have been conducted recently in order to replace toxic organic contaminants of the processes with environmentally friendly solvents...
August 17, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/28811306/replication-and-validation-of-genetic-polymorphisms-associated-with-survival-after-allogeneic-blood-or-marrow-transplant
#2
Ezgi Karaesmen, Abbas A Rizvi, Leah Preus, Philip L McCarthy, Marcelo C Pasquini, Kenan Onel, Xiaochun Zhu, Stephen Spellman, Christopher A Haiman, Daniel O Stram, Loreall Pooler, Xin Sheng, Qianqian Zhu, Li Yan, Qian Liu, Qiang Hu, Amy Webb, Guy Brock, Alyssa I Clay-Gilmour, Sebastiano Battaglia, David Tritchler, Song Liu, Theresa Hahn, Lara E Sucheston-Campbell
Multiple candidate gene association studies of non-HLA single nucleotide polymorphisms (SNPs) and outcomes after blood or marrow transplant (BMT) have been conducted. We identified 70 publications reporting 45 SNPs in 36 genes significantly associated with disease-related mortality, progression-free survival, transplant-related mortality and/or overall survival after BMT. Replication and validation of these SNP associations were performed using DISCOVeRY-BMT, a well-powered genome-wide association study consisting of two cohorts, totaling 2,883 BMT recipients with AML, ALL or MDS and their HLA-matched unrelated donors, treated from 2000-2011 and reported to the CIBMTR...
August 15, 2017: Blood
https://www.readbyqxmd.com/read/28805795/m3-an-integrative-framework-for-structure-determination-of-molecular-machines
#3
Ezgi Karaca, João P G L M Rodrigues, Andrea Graziadei, Alexandre M J J Bonvin, Teresa Carlomagno
We present a broadly applicable, user-friendly protocol that incorporates sparse and hybrid experimental data to calculate quasi-atomic-resolution structures of molecular machines. The protocol uses the HADDOCK framework, accounts for extensive structural rearrangements both at the domain and atomic levels and accepts input from all structural and biochemical experiments whose data can be translated into interatomic distances and/or molecular shapes.
August 14, 2017: Nature Methods
https://www.readbyqxmd.com/read/28793828/the-predictive-factors-for-perceived-social-support-among-cancer-patients-and-caregiver-burden-of-their-family-caregivers-in-turkish-population
#4
Basak Oven Ustaalioglu, Ezgi Acar, Mecit Caliskan
OBJECTIVES: We aimed to identify the predictive factors for the perceived family social support among cancer patients and caregiver burden of their family caregivers. METHODS: Participants were 302 cancer patients and their family caregivers. Family social support scale was used for cancer patients, burden interview was used for family caregivers.All subjects also completed Beck depression invantery. The related socio-demographical factors with perceived social support (PSS) and caregiver burden were evaluated by correlation analysis...
August 9, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28739561/smartphone-based-monitoring-of-objective-and-subjective-data-in-affective-disorders-where-are-we-and-where-are-we-going-systematic-review
#5
Ezgi Dogan, Christian Sander, Xenija Wagner, Ulrich Hegerl, Elisabeth Kohls
BACKGROUND: Electronic mental health interventions for mood disorders have increased rapidly over the past decade, most recently in the form of various systems and apps that are delivered via smartphones. OBJECTIVE: We aim to provide an overview of studies on smartphone-based systems that combine subjective ratings with objectively measured data for longitudinal monitoring of patients with affective disorders. Specifically, we aim to examine current knowledge on: (1) the feasibility of, and adherence to, such systems; (2) the association of monitored data with mood status; and (3) the effects of monitoring on clinical outcomes...
July 24, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28735785/effect-of-the-simultaneous-working-length-control-during-root-canal-preparation-on-postoperative-pain
#6
Hakan Arslan, Yahya Güven, Ertuğrul Karataş, Ezgi Doğanay
AIM: The aim of this study was to evaluate the effect of simultaneous length control during root canal preparation on postoperative pain compared with separate working length determination and root canal preparation. The design was a parallel-group, randomized, controlled trial with 2 arms. METHODS: Forty-four molar teeth were randomly divided into 2 groups (n = 22), a control group (separate length determination and root canal preparation) and a simultaneous length control during root canal preparation group...
July 20, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28708954/pneumococcal-and-influenza-vaccination-status-of-hospitalized-adults-with-community-acquired-pneumonia-and-the-effects-of-vaccination-on-clinical-presentation
#7
Ezgi Demirdogen Cetinoglu, Esra Uzaslan, Abdullah Sayıner, Aykut Cilli, Oguz Kılınc, Aysın Sakar Coskun, Armağan Hazar, Nurdan Kokturk, Ayten Filiz, Mehmet Polatli
BACKGROUND: Previous reports have shown that vaccination rates of adult at-risk populations are low in Turkey. There are differing reports with regards to the effectiveness of the influenza and the pneumococcal polysaccharide vaccine (PPSV23) on the clinical outcomes of community acquired pneumonia (CAP). The purpose of this study was to analyze the influenza (FV) and pneumococcal vaccination (PV) status, the factors that influence the receipt of influenza/pneumococcal vaccine and the effects of prior vaccination on the clinical outcomes in adults hospitalized with CAP...
July 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28708790/trends-of-gynecological-cancers-in-turkey-towards-europe-or-asia
#8
Murat Gultekin, Irem Kucukyildiz, Mujdegul Zayifoglu Karaca, Selin Dundar, Guledal Boztas, Semra Hatice Turan, Ezgi Hacikamiloglu, Bekir Keskinkilic
OBJECTIVE: The aim of this study was to evaluate nationwide gynecological cancer trends in Turkey. METHODS: National cancer registry data (2009-2013) of Turkish Ministry of Health were evaluated. Ovarian, cervical, endometrial, vulvar, vaginal, and tubal cancers are evaluated with respect to age of diagnosis, incidence rates within years, stage, histological distributions, and mortality rates. Data were collected from active cancer registry centers, which increased from 23% in 2009 to 47...
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28702107/acute-appendicitis-due-to-hair-follicle-obstruction-a-rare-case-report
#9
Samir Abdullazade, Bahattin Bayar, Mehmet Can, Ezgi Altinsoy, Ilker Kiziloglu
No abstract text is available yet for this article.
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28681097/characterizing-diagnostic-search-patterns-in-digital-breast-pathology-scanners-and-drillers
#10
Ezgi Mercan, Linda G Shapiro, Tad T Brunyé, Donald L Weaver, Joann G Elmore
Following a baseline demographic survey, 87 pathologists interpreted 240 digital whole slide images of breast biopsy specimens representing a range of diagnostic categories from benign to atypia, ductal carcinoma in situ, and invasive cancer. A web-based viewer recorded pathologists' behaviors while interpreting a subset of 60 randomly selected and randomly ordered slides. To characterize diagnostic search patterns, we used the viewport location, time stamp, and zoom level data to calculate four variables: average zoom level, maximum zoom level, zoom level variance, and scanning percentage...
July 5, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28676275/testicular-adrenal-rest-tumor-tart-in-congenital-adrenal-hyperplasia
#11
Hatice Ozisik, Banu Sarer Yurekli, Ilgin Yildirim Simsir, Ilker Altun, Utku Soyaltin, Ezgi Guler, Huseyin Onay, Banu Sarsik, Fusun Saygili
Congenital adrenal hyperplasia is one of the most common autosomal recessive genetic disorders. Testicular adrenal tumors are significant complications of congenital adrenal hyperplasia. We would like to present two patients of testicular adrenal rest tumors. Patient 1 24 year-old male, he was diagnosed with congenital adrenal hyperplasia at the age of 8 due to precocious puberty. He received hydro-cortisone treatment until the age of 18. Testicular mass had been detected and right radical orchiectomy had been applied 6 months ago and reported as testicular adrenal rest tumor...
July 1, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28667113/a-human-gut-commensal-ferments-cranberry-carbohydrates-to-produce-formate
#12
Ezgi Özcan, Jiadong Sun, David C Rowley, David A Sela
Commensal bifidobacteria colonize the human gastrointestinal tract and catabolize glycans that are impervious to host digestion. Accordingly, Bifidobacterium longum typically secrete acetate and lactate as fermentative endproducts. This study tested the hypothesis that B. longum utilize cranberry-derived xyloglucans in a strain-dependent manner. Interestingly, the B. longum strain that efficiently utilizes cranberry xyloglucans secrete 2.0-2.5 moles acetate:lactate. The 1.5 ratio theoretical yield obtained in hexose fermentations shifts during xyloglucan metabolism...
June 30, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28664934/cytologic-predictors-of-malignancy-in-bile-duct-brushings-a-multi-reviewer-analysis-of-60-cases
#13
Vaidehi Avadhani, Ezgi Hacihasanoglu, Bahar Memis, Burcin Pehlivanoglu, Krisztina Z Hanley, Uma Krishnamurti, Alyssa M Krasinskas, Adeboye O Osunkoya, Lauren M Daniels, Alexa A Freedman, Michael Goodman, Volkan Adsay, Michelle D Reid
Diagnosing malignancy in bile duct brushings is highly challenging. Seven reviewers of variable backgrounds and levels of participation in bile duct brushing sign out blindly reviewed 60 specimens (30 malignant with histologic confirmation and 30 benign (15 stented) with resection or ≥18 months of uneventful follow-up), testing the utility of 14 malignant characteristics. Eleven characteristics were statistically significantly associated with malignancy including 3-dimensional clusters (63% in malignant vs 3% in benign, odds ratio 50, P=0...
June 30, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28661478/kdm2b-an-h3k36-specific-demethylase-regulates-apoptotic-response-of-gbm-cells-to-trail
#14
Ibrahim Cagri Kurt, Ilknur Sur, Ezgi Kaya, Ahmet Cingoz, Selena Kazancioglu, Zeynep Kahya, Omer Duhan Toparlak, Filiz Senbabaoglu, Zeynep Kaya, Ezgi Ozyerli, Sercin Karahüseyinoglu, Nathan A Lack, Zeynep H Gümüs, Tamer T Onder, Tugba Bagci-Onder
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively kill tumor cells. TRAIL resistance in cancers is associated with aberrant expression of the key components of the apoptotic program. However, how these components are regulated at the epigenetic level is not understood. In this study, we investigated novel epigenetic mechanisms regulating TRAIL response in glioblastoma multiforme (GBM) cells by a short-hairpin RNA loss-of-function screen. We interrogated 48 genes in DNA and histone modification pathways and identified KDM2B, an H3K36-specific demethylase, as a novel regulator of TRAIL response...
June 29, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28626961/comparing-polyarteritis-nodosa-in-children-and-adults-a-single-center-study
#15
Abdulsamet Erden, Ezgi D Batu, Hafize E Sönmez, Alper Sarı, Berkan Armagan, Zehra S Arıcı, Emre Bilgin, Umut Kalyoncu, Ömer Karadağ, Yelda Bilginer, Ali Ihsan Ertenli, Seza Özen
OBJECTIVE: Polyarteritis nodosa (PAN) is a necrotizing vasculitis of medium/small arteries. We aimed to examine the characteristics of adult- and childhood-onset PAN. METHODS: Fifteen pediatric (˂ 18 years) and 22 adult PAN patients who fulfilled the Ankara 2008 and American College of Rheumatology 1990 criteria, respectively, were included in the study. RESULTS: Five children had cutaneous and all the rest of the patients had systemic PAN...
June 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28607584/a-combined-ulbp2-and-sema5a-expression-signature-as-a-prognostic-and-predictive-biomarker-for-colon-cancer
#16
Secil Demirkol, Ismail Gomceli, Murat Isbilen, Baris Emre Dayanc, Mesut Tez, Erdal Birol Bostanci, Nesrin Turhan, Musa Akoglu, Ezgi Ozyerli, Sevi Durdu, Ozlen Konu, Aviram Nissan, Mithat Gonen, Ali Osmay Gure
Background: Prognostic biomarkers for cancer have the power to change the course of disease if they add value beyond known prognostic factors, if they can help shape treatment protocols, and if they are reliable. The aim of this study was to identify such biomarkers for colon cancer and to understand the molecular mechanisms leading to prognostic stratifications based on these biomarkers. Methods and Findings: We used an in house R based script (SSAT) for the in silico discovery of stage-independent prognostic biomarkers using two cohorts, GSE17536 and GSE17537, that include 177 and 55 colon cancer patients, respectively...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28604465/brachial-plexus-injury-associated-with-subclavian-vein-cannulation-a-case-report
#17
Ezgi Gozubuyuk, Mehmet I Buget, Turgut Akgul, Demet Altun, Suleyman Kuçukay
We documented brachial plexus injury by electromyography and magnetic resonance imaging secondary to needle sticks for central line insertion. This type of complication is rare in the literature, as few case reports exist. Brachial plexus injury can happen because of anatomic variations. Nevertheless, multiple attempts or introducer needle rotations should be avoided during subclavian vein catheterization. Pain that emerges in the ipsilateral arm after subclavian catheter placement should be taken into serious consideration...
June 8, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28602636/extensive-phenotyping-of-two-arx-polyalanine-expansion-mutation-mouse-models-that-span-clinical-spectrum-of-intellectual-disability-and-epilepsy
#18
Matilda R Jackson, Kristie Lee, Tessa Mattiske, Emily J Jaehne, Ezgi Ozturk, Bernhard T Baune, Terence J O'Brien, Nigel Jones, Cheryl Shoubridge
The Aristaless-related homeobox gene (ARX) is a known intellectual disability (ID) gene that frequently presents with X-linked infantile spasm syndrome as a comorbidity. ID with epilepsy in children is a chronic and devastating disorder that has poor treatment options and disease outcomes. To gain a better understanding of the role that mutations in ARX play in ID and epilepsy, we investigate ARX patient mutations modelled in mice. Over half of all ARX mutations result from expansions of the first two polyalanine (PA1 and PA2 respectively) tracts...
September 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28593113/the-added-value-of-diffusion-magnetic-resonance-imaging-in-the-diagnosis-and-posttreatment-evaluation-of-skull-base-chordomas
#19
Ezgi Guler, Burce Ozgen, Melike Mut, Figen Soylemezoglu, Kader Karli Oguz
Objectives  To determine the use of diffusion-weighted imaging (DWI) in the pre- and posttreatment evaluation of skull base chordomas. Design  Retrospective study. Setting  Tertiary care university hospital. Participants  In total, 17 patients with histopathological diagnosis of chordoma who had magnetic resonance (MR) imaging and DWI were evaluated. Of them, 13 patients had posttreatment MR imaging including DWI. Main Outcome Measures  Three apparent diffusion coefficient (ADC) values were obtained from tumor, and an ADC value was measured from pons for the purpose of normalization...
June 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28584381/cutaneous-angiosarcoma-mimicking-panniculitis-in-the-lower-extremities
#20
Sumeyre Seda Ertekin, Ezgi Ozkur, Cem Leblebici, Mehmet Salih Gürel, Asli Vefa Turgut Erdemir
No abstract text is available yet for this article.
May 2017: Indian Journal of Dermatology
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