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Cometic Surgery

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https://www.readbyqxmd.com/read/29432394/outcomes-reported-after-surgery-for-cauda-equina-syndrome-a-systematic-literature-review
#1
Nisaharan Srikandarajah, Martin Wilby, Simon Clark, Adam Noble, Paula Williamson, Tony Marson
STUDY DESIGN: This is a systematic literature review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. OBJECTIVE: To assess the outcomes reported in trials and observational studies of surgery for cauda equina syndrome, to inform the development of a core outcome set. SUMMARY OF BACKGROUND DATA: Scoping searches revealed that there were inconsistencies in which outcomes were reported and how they were measured in research studies for patients who had undergone surgery for Cauda Equina Syndrome...
February 9, 2018: Spine
https://www.readbyqxmd.com/read/29352286/echogenic-foci-with-comet-tail-artifact-in-resected-thyroid-nodules-not-an-absolute-predictor-of-benign-disease
#2
Hongxun Wu, Bingjie Zhang, Jie Li, Qianyun Liu, Tingting Zhao
The purpose of this study was to evaluate the frequency of echogenic foci with comet-tail artifact in histologically proven thyroid nodules, and to determine the types of echogenic foci with comet-tail artifact that are associated with malignancy. We retrospectively analyzed the sonographic findings of echogenic foci with comet-tail artifact, present in thyroid nodules in 63 patients who underwent surgery for thyroid nodules at our institution between January 2016 and September 2016. The sonographic findings (appearance and background of echogenic foci, shape of comet-tail artifact) in benign and malignant nodules were compared...
2018: PloS One
https://www.readbyqxmd.com/read/29246177/score-it-selecting-core-outcomes-for-randomised-effectiveness-trials-in-type-2-diabetes-a-systematic-review-of-registered-trials
#3
REVIEW
Nicola L Harman, Rebecca James, John Wilding, Paula R Williamson
BACKGROUND: Outcomes measured in clinical trials should be meaningful to patients, healthcare professionals and researchers, yet there is heterogeneity in the outcomes used across trials. This inconsistency impacts on the ability to compare findings and may mean that the results have little importance to healthcare professionals and the patients that they care for. The aim of the present study is to review the outcomes used in registered trials of therapies for type 2 diabetes mellitus as the first step in the development of a core outcome set for effectiveness trials in type 2 diabetes...
December 15, 2017: Trials
https://www.readbyqxmd.com/read/28925613/surgery-versus-monitoring-and-endocrine-therapy-for-low-risk-dcis-the-comet-trial
#4
Linda M Youngwirth, Judy C Boughey, E Shelley Hwang
No abstract text is available yet for this article.
January 2017: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28844704/gallbladder-adenomyomatosis-diagnosis-and-management
#5
N Golse, M Lewin, A Rode, M Sebagh, J-Y Mabrut
Gallbladder (GB) adenomyomatosis (ADM) is a benign, acquired anomaly, characterized by hypertrophy of the mucosal epithelium that invaginates into the interstices of a thickened muscularis forming so-called Rokitansky-Aschoff sinuses. There are three forms of ADM: segmental, fundal and more rarely, diffuse. Etiology and pathogenesis are not well understood but chronic inflammation of the GB is a necessary precursor. Prevalence of ADM in cholecystectomy specimens is estimated between 1% and 9% with a balanced sex ratio; the incidence increases after the age of 50...
October 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28709445/twin-twin-transfusion-syndrome-study-protocol-for-developing-disseminating-and-implementing-a-core-outcome-set
#6
Asma Khalil, Helen Perry, James Duffy, Keith Reed, Ahmet Baschat, Jan Deprest, Kurt Hecher, Liesbeth Lewi, Enrico Lopriore, Dick Oepkes
BACKGROUND: Twin-Twin Transfusion Syndrome (TTTS) is associated with an increased risk of perinatal mortality and morbidity. Several treatment interventions have been described for TTTS, including fetoscopic laser surgery, amnioreduction, septostomy, expectant management, and pregnancy termination. Over the last decade, fetoscopic laser surgery has become the primary treatment. The literature to date reports on many different outcomes, making it difficult to compare results or combine data from individual studies, limiting the value of research to guide clinical practice...
July 14, 2017: Trials
https://www.readbyqxmd.com/read/28701207/development-of-a-core-outcome-set-for-clinical-trials-in-squamous-cell-carcinoma-study-protocol-for-a-systematic-review-of-the-literature-and-identification-of-a-core-outcome-set-using-a-delphi-survey
#7
Daniel I Schlessinger, Sanjana Iyengar, Arianna F Yanes, Sarah G Chiren, Victoria Godinez-Puig, Brian R Chen, Anastasia O Kurta, Jochen Schmitt, Stefanie Deckert, Karina C Furlan, Emily Poon, Todd V Cartee, Ian A Maher, Murad Alam, Joseph F Sobanko
BACKGROUND: Squamous cell carcinoma (SCC) is a common skin cancer that poses a risk of metastasis. Clinical investigations into SCC treatment are common, but the outcomes reported are highly variable, omitted, or clinically irrelevant. The outcome heterogeneity and reporting bias of these studies leave clinicians unable to accurately compare studies. Core outcome sets (COSs) are an agreed minimum set of outcomes recommended to be measured and reported in all clinical trials of a given condition or disease...
July 12, 2017: Trials
https://www.readbyqxmd.com/read/28657937/laparoscopic-versus-open-resection-for-colorectal-liver-metastases-the-oslo-comet-randomized-controlled-trial
#8
Åsmund Avdem Fretland, Vegar Johansen Dagenborg, Gudrun Maria Waaler Bjørnelv, Airazat M Kazaryan, Ronny Kristiansen, Morten Wang Fagerland, John Hausken, Tor Inge Tønnessen, Andreas Abildgaard, Leonid Barkhatov, Sheraz Yaqub, Bård I Røsok, Bjørn Atle Bjørnbeth, Marit Helen Andersen, Kjersti Flatmark, Eline Aas, Bjørn Edwin
OBJECTIVE: To perform the first randomized controlled trial to compare laparoscopic and open liver resection. SUMMARY BACKGROUND DATA: Laparoscopic liver resection is increasingly used for the surgical treatment of liver tumors. However, high-level evidence to conclude that laparoscopic liver resection is superior to open liver resection is lacking. METHODS: Explanatory, assessor-blinded, single center, randomized superiority trial recruiting patients from Oslo University Hospital, Oslo, Norway from February 2012 to January 2016...
February 2018: Annals of Surgery
https://www.readbyqxmd.com/read/28202419/expression-of-dna-repair-genes-in-lens-cortex-of-age-related-cortical-cataract
#9
Yong Wang, Junfang Zhang, Jian Wu, Huaijin Guan
The formation and development of age-related cataract (ARC) has been demonstrated to have the involvement of defective DNA repair in lens epithelial cells (LECs). This study aimed to investigate DNA repair genes expression in human lens cortex collected from age-related cortical cataract (ARCC) and controls during surgery. The expression levels of the genes were evaluated by xx genes microarray analysis. The results were further confirmed by Quantitative Real-Time PCR (qRT-PCR). The mRNA levels of 7 genes decreased and 4 genes out of 92 genes increased in lens cortex of ARCCs compared with controls with the fold change >1...
April 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27867550/amide-linked-local-anesthetics-induce-apoptosis-in-human-non-small-cell-lung-cancer
#10
Hong-Wei Wang, Le-Yi Wang, Li Jiang, Su-Ming Tian, Tai-Di Zhong, Xiang-Ming Fang
BACKGROUND: A retrospective analysis of patients undergoing cancer surgery suggested that using local anesthetics could reduce cancer recurrence and improve survival rate. Previous studies have indicated that local anesthetics may induce apoptosis in several kinds of cells in vitro, but the mechanism is unclear. METHODS: Cell viability was analyzed by MTS; reactive oxygen species (ROS), mitochondrial membrane potential (MMP, ∆Ψm), cell cycle distribution, and cell apoptosis assay were detected by flow cytometry; DNA damage was measured by comet assay; cell invasion and migration were observed by microscopy; The expression level of related proteins was detected by western blot assay...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27855723/exceeding-the-recruitment-target-in-a-primary-care-paediatric-trial-an-evaluation-of-the-choice-of-moisturiser-for-eczema-treatment-comet-feasibility-randomised-controlled-trial
#11
Kingsley Powell, Victoria J Wilson, Niamh M Redmond, Daisy M Gaunt, Matthew J Ridd
BACKGROUND: Recruiting to target in randomised controlled trials of investigational medicinal products (CTIMPs) in primary care and paediatric populations is notoriously difficult. More evidence is needed for effective recruitment strategies in these settings. We report on the impact of different recruitment strategies used in the Choice of Moisturiser in Eczema Treatment (COMET) study - a feasibility trial comparing the effectiveness of four emollients for the treatment of childhood eczema - recruiting via general practitioner (GP) surgeries...
November 17, 2016: Trials
https://www.readbyqxmd.com/read/27644442/chloroquine-an-autophagy-inhibitor-potentiates-the-radiosensitivity-of-glioma-initiating-cells-by-inhibiting-autophagy-and-activating-apoptosis
#12
Hongxing Ye, Mantao Chen, Fei Cao, Hongguang Huang, Renya Zhan, Xiujue Zheng
BACKGROUND: Glioblastoma is refractory to conventional treatment, which is combined of surgery, chemotherapy and radiotherapy. Recent studies have shown that glioma initiating cells (GICs) contribute to tumorigenesis and radioresistance. Recently, other studies showed that the GICs use the autophagy as the major pathway to survive. Chloroquine, an anti-malarial chemical, is an autophagic inhibitor which blocks autophagosome fusion with lysosome and slows down lysosomal acidification. The aim of this study was to explore the mechanisms of chloroquine on the radiosensitivity of GICs...
September 20, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27507558/long-term-result-of-autologous-cultivated-oral-mucosal-epithelial-transplantation-for-severe-ocular-surface-disease
#13
Pinnita Prabhasawat, Pattama Ekpo, Mongkol Uiprasertkul, Suksri Chotikavanich, Nattaporn Tesavibul, Kanograt Pornpanich, Panitee Luemsamran
The present study aimed to investigate the clinical outcomes of autologous cultivated oral mucosal epithelial transplantation (COMET) on human amniotic membrane (AM) for corneal limbal stem cell deficiency (LSCD). In this prospective, noncomparative case series, 20 eyes (18 patients) with bilateral severe ocular surface disease were chosen to undergo COMET on human AM. The primary outcome was clinical success, and the secondary outcomes were the best-corrected visual acuity difference, corneal opacification, symblepharon formation, and complications...
September 2016: Cell and Tissue Banking
https://www.readbyqxmd.com/read/27062561/evaluation-of-genotoxicity-of-general-anesthesia-maintained-with-desflurane-in-patients-under-minor-surgery
#14
Flávia R Nogueira, Leandro G Braz, Leonardo R de Andrade, Ana Lygia R de Carvalho, Luiz A Vane, Norma Sueli P Módolo, Aline G Aun, Kátina M Souza, José Reinaldo C Braz, Mariana G Braz
There is controversy over the genotoxic effects of volatile anesthetics. The available literature on the genotoxicity of desflurane, one of the newest volatile halogenated agents used for general anesthesia maintenance, is scarce. This study aimed to evaluate the genotoxic potential of desflurane in 15 patients without comorbidities, of both sexes, who underwent minor surgeries lasting at least 90 min. Patients enrolled in the study received desflurane anesthesia (6%); blood samples were collected before anesthesia induction (T0), 90 min after the beginning of anesthesia (T1), and on the day following surgery (T2)...
May 2016: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/26625730/a-core-outcome-set-for-all-types-of-cardiac-surgery-effectiveness-trials-a-study-protocol-for-an-international-edelphi-survey-to-achieve-consensus-on-what-to-measure-and-the-subsequent-selection-of-measurement-instruments
#15
MULTICENTER STUDY
A Moza, C Benstoem, R Autschbach, C Stoppe, A Goetzenich
BACKGROUND: Cardiovascular disease (CVD) is a major contributor to the burden of disease and the number one cause of death worldwide. From 1990 until today, more people died from coronary heart disease than from any other cause. CVD is regularly treated with minimally or non-minimally invasive off- or on-pump cardiothoracic surgery and several interventions related to the outcome of the surgical procedures have been evaluated in clinical trials, but heterogeneity in outcome reporting hinders comparison of interventions across trials and limits the ability of research synthesis...
2015: Trials
https://www.readbyqxmd.com/read/26604642/n-acetylcysteine-modulates-angiogenesis-and-vasodilation-in-stomach-such-as-dna-damage-in-blood-of-portal-hypertensive-rats
#16
Francielli Licks, Renata Minuzzo Hartmann, Camila Marques, Elizângela Schemitt, Josieli Raskopf Colares, Mariana do Couto Soares, Juliana Reys, Camila Fisher, Juliana da Silva, Norma Possa Marroni
AIM: To evaluate the antioxidant effect of N-acetylcysteine (NAC) on the stomach of rats with portal hypertension. METHODS: Twenty-four male Wistar rats weighing ± 250 g were divided into four experimental groups (n = 6 each): Sham-operated (SO), SO + NAC, partial portal vein ligation (PPVL), and PPVL + NAC. Treatment with NAC in a dose of 10 mg/kg (i.p.) diluted in 0.6 mL of saline solution was administered daily for 7 d starting 8 d after the surgery. Animals from the PPVL and SO group received saline solution (0...
November 21, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26496309/inflammatory-response-after-laparoscopic-versus-open-resection-of-colorectal-liver-metastases-data-from-the-oslo-comet-trial
#17
RANDOMIZED CONTROLLED TRIAL
Asmund Avdem Fretland, Andrey Sokolov, Nadya Postriganova, Airazat M Kazaryan, Soren E Pischke, Per H Nilsson, Ingrid Nygren Rognes, Bjorn Atle Bjornbeth, Morten Wang Fagerland, Tom Eirik Mollnes, Bjorn Edwin
Laparoscopic and open liver resection have not been compared in randomized trials. The aim of the current study was to compare the inflammatory response after laparoscopic and open resection of colorectal liver metastases (CLM) in a randomized controlled trial.This was a predefined exploratory substudy within the Oslo CoMet-study. Forty-five patients with CLM were randomized to laparoscopic (n = 23) or open (n = 22) resection. Ethylenediaminetetraacetic acid-plasma samples were collected preoperatively and at defined time points during and after surgery and snap frozen at -80 C...
October 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26451366/cultivated-oral-mucosa-epithelium-in-ocular-surface-reconstruction-in-aniridia-patients
#18
Dariusz Dobrowolski, Boguslawa Orzechowska-Wylegala, Bogumil Wowra, Ewa Wroblewska-Czajka, Maria Grolik, Krzysztof Szczubialka, Maria Nowakowska, Domenico Puzzolo, Edward A Wylegala, Antonio Micali, Pasquale Aragona
PURPOSE: Efficacy of cultivated oral mucosa epithelial transplantation (COMET) procedure in corneal epithelium restoration of aniridia patients. METHODS: Study subjects were aniridia patients (13 patients; 17 eyes) with irregular, vascular conjunctival pannus involving visual axis who underwent autologous transplantation of cultivated epithelium. For the procedure oral mucosa epithelial cells were obtained from buccal mucosa with further enzymatic treatment. Suspension of single cells was seeded on previously prepared denuded amniotic membrane...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26339365/cytologic-clinicopathologic-and-molecular-features-of-papillary-thyroid-carcinoma-with-prominent-hobnail-features-10-case-reports-and-systematic-literature-review
#19
REVIEW
Young Sub Lee, Yourha Kim, Sora Jeon, Ja Seong Bae, So Lyung Jung, Chan Kwon Jung
The hobnail variant of papillary thyroid carcinoma (PTC) is a rare, aggressive variant in which > 30% of the tumor cells have hobnail features. The clinical behavior and pathologic characteristics of these tumors are still unclear due to the rarity of the entity. The present study aimed to investigate cytologic, clinical, pathological, and molecular features of the hobnail variant from our data and from the literature. We retrospectively retrieved 10 cases of hobnail variant from 2,904 consecutive PTC patients...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26252290/isoflurane-and-propofol-contribute-to-increasing-the-antioxidant-status-of-patients-during-minor-elective-surgery-a-randomized-clinical-study
#20
RANDOMIZED CONTROLLED TRIAL
Mariana G Braz, Leandro G Braz, Cristiana M M Freire, Lorena M C Lucio, José R C Braz, Guangwen Tang, Daisy M F Salvadori, Kyung-Jin Yeum
Isoflurane is a volatile halogenated anesthetic used especially for anesthesia maintenance whereas propofol is a venous anesthetic utilized for anesthesia induction and maintenance, and reportedly an antioxidant. However, there are still controversies related to isoflurane-induced oxidative stress and it remains unanswered whether the antioxidant effects occur in patients under propofol anesthesia.Taking into account the importance of better understanding the role of anesthetics on oxidative stress in anesthetized patients, the present study was designed to evaluate general anesthesia maintained with isoflurane or propofol on antioxidant status in patients who underwent minimally invasive surgeries...
August 2015: Medicine (Baltimore)
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