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Cometic Surgery

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https://www.readbyqxmd.com/read/28925613/surgery-versus-monitoring-and-endocrine-therapy-for-low-risk-dcis-the-comet-trial
#1
Linda M Youngwirth, Judy C Boughey, E Shelley Hwang
No abstract text is available yet for this article.
January 2017: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28844704/gallbladder-adenomyomatosis-diagnosis-and-management
#2
N Golse, M Lewin, A Rode, M Sebagh, J-Y Mabrut
Gallbladder (GB) adenomyomatosis (ADM) is a benign, acquired anomaly, characterized by hypertrophy of the mucosal epithelium that invaginates into the interstices of a thickened muscularis forming so-called Rokitansky-Aschoff sinuses. There are three forms of ADM: segmental, fundal and more rarely, diffuse. Etiology and pathogenesis are not well understood but chronic inflammation of the GB is a necessary precursor. Prevalence of ADM in cholecystectomy specimens is estimated between 1% and 9% with a balanced sex ratio; the incidence increases after the age of 50...
October 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28709445/twin-twin-transfusion-syndrome-study-protocol-for-developing-disseminating-and-implementing-a-core-outcome-set
#3
Asma Khalil, Helen Perry, James Duffy, Keith Reed, Ahmet Baschat, Jan Deprest, Kurt Hecher, Liesbeth Lewi, Enrico Lopriore, Dick Oepkes
BACKGROUND: Twin-Twin Transfusion Syndrome (TTTS) is associated with an increased risk of perinatal mortality and morbidity. Several treatment interventions have been described for TTTS, including fetoscopic laser surgery, amnioreduction, septostomy, expectant management, and pregnancy termination. Over the last decade, fetoscopic laser surgery has become the primary treatment. The literature to date reports on many different outcomes, making it difficult to compare results or combine data from individual studies, limiting the value of research to guide clinical practice...
July 14, 2017: Trials
https://www.readbyqxmd.com/read/28701207/development-of-a-core-outcome-set-for-clinical-trials-in-squamous-cell-carcinoma-study-protocol-for-a-systematic-review-of-the-literature-and-identification-of-a-core-outcome-set-using-a-delphi-survey
#4
Daniel I Schlessinger, Sanjana Iyengar, Arianna F Yanes, Sarah G Chiren, Victoria Godinez-Puig, Brian R Chen, Anastasia O Kurta, Jochen Schmitt, Stefanie Deckert, Karina C Furlan, Emily Poon, Todd V Cartee, Ian A Maher, Murad Alam, Joseph F Sobanko
BACKGROUND: Squamous cell carcinoma (SCC) is a common skin cancer that poses a risk of metastasis. Clinical investigations into SCC treatment are common, but the outcomes reported are highly variable, omitted, or clinically irrelevant. The outcome heterogeneity and reporting bias of these studies leave clinicians unable to accurately compare studies. Core outcome sets (COSs) are an agreed minimum set of outcomes recommended to be measured and reported in all clinical trials of a given condition or disease...
July 12, 2017: Trials
https://www.readbyqxmd.com/read/28657937/laparoscopic-versus-open-resection-for-colorectal-liver-metastases-the-oslo-comet-randomized-controlled-trial
#5
Åsmund Avdem Fretland, Vegar Johansen Dagenborg, Gudrun Maria Waaler Bjørnelv, Airazat M Kazaryan, Ronny Kristiansen, Morten Wang Fagerland, John Hausken, Tor Inge Tønnessen, Andreas Abildgaard, Leonid Barkhatov, Sheraz Yaqub, Bård I Røsok, Bjørn Atle Bjørnbeth, Marit Helen Andersen, Kjersti Flatmark, Eline Aas, Bjørn Edwin
OBJECTIVE: To perform the first randomized controlled trial to compare laparoscopic and open liver resection. SUMMARY BACKGROUND DATA: Laparoscopic liver resection is increasingly used for the surgical treatment of liver tumors. However, high-level evidence to conclude that laparoscopic liver resection is superior to open liver resection is lacking. METHODS: Explanatory, assessor-blinded, single center, randomized superiority trial recruiting patients from Oslo University Hospital, Oslo, Norway from February 2012 to January 2016...
June 27, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28202419/expression-of-dna-repair-genes-in-lens-cortex-of-age-related-cortical-cataract
#6
Yong Wang, Junfang Zhang, Jian Wu, Huaijin Guan
The formation and development of age-related cataract (ARC) has been demonstrated to have the involvement of defective DNA repair in lens epithelial cells (LECs). This study aimed to investigate DNA repair genes expression in human lens cortex collected from age-related cortical cataract (ARCC) and controls during surgery. The expression levels of the genes were evaluated by xx genes microarray analysis. The results were further confirmed by Quantitative Real-Time PCR (qRT-PCR). The mRNA levels of 7 genes decreased and 4 genes out of 92 genes increased in lens cortex of ARCCs compared with controls with the fold change >1...
April 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27867550/amide-linked-local-anesthetics-induce-apoptosis-in-human-non-small-cell-lung-cancer
#7
Hong-Wei Wang, Le-Yi Wang, Li Jiang, Su-Ming Tian, Tai-Di Zhong, Xiang-Ming Fang
BACKGROUND: A retrospective analysis of patients undergoing cancer surgery suggested that using local anesthetics could reduce cancer recurrence and improve survival rate. Previous studies have indicated that local anesthetics may induce apoptosis in several kinds of cells in vitro, but the mechanism is unclear. METHODS: Cell viability was analyzed by MTS; reactive oxygen species (ROS), mitochondrial membrane potential (MMP, ∆Ψm), cell cycle distribution, and cell apoptosis assay were detected by flow cytometry; DNA damage was measured by comet assay; cell invasion and migration were observed by microscopy; The expression level of related proteins was detected by western blot assay...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27855723/exceeding-the-recruitment-target-in-a-primary-care-paediatric-trial-an-evaluation-of-the-choice-of-moisturiser-for-eczema-treatment-comet-feasibility-randomised-controlled-trial
#8
Kingsley Powell, Victoria J Wilson, Niamh M Redmond, Daisy M Gaunt, Matthew J Ridd
BACKGROUND: Recruiting to target in randomised controlled trials of investigational medicinal products (CTIMPs) in primary care and paediatric populations is notoriously difficult. More evidence is needed for effective recruitment strategies in these settings. We report on the impact of different recruitment strategies used in the Choice of Moisturiser in Eczema Treatment (COMET) study - a feasibility trial comparing the effectiveness of four emollients for the treatment of childhood eczema - recruiting via general practitioner (GP) surgeries...
November 17, 2016: Trials
https://www.readbyqxmd.com/read/27644442/chloroquine-an-autophagy-inhibitor-potentiates-the-radiosensitivity-of-glioma-initiating-cells-by-inhibiting-autophagy-and-activating-apoptosis
#9
Hongxing Ye, Mantao Chen, Fei Cao, Hongguang Huang, Renya Zhan, Xiujue Zheng
BACKGROUND: Glioblastoma is refractory to conventional treatment, which is combined of surgery, chemotherapy and radiotherapy. Recent studies have shown that glioma initiating cells (GICs) contribute to tumorigenesis and radioresistance. Recently, other studies showed that the GICs use the autophagy as the major pathway to survive. Chloroquine, an anti-malarial chemical, is an autophagic inhibitor which blocks autophagosome fusion with lysosome and slows down lysosomal acidification. The aim of this study was to explore the mechanisms of chloroquine on the radiosensitivity of GICs...
September 20, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27507558/long-term-result-of-autologous-cultivated-oral-mucosal-epithelial-transplantation-for-severe-ocular-surface-disease
#10
Pinnita Prabhasawat, Pattama Ekpo, Mongkol Uiprasertkul, Suksri Chotikavanich, Nattaporn Tesavibul, Kanograt Pornpanich, Panitee Luemsamran
The present study aimed to investigate the clinical outcomes of autologous cultivated oral mucosal epithelial transplantation (COMET) on human amniotic membrane (AM) for corneal limbal stem cell deficiency (LSCD). In this prospective, noncomparative case series, 20 eyes (18 patients) with bilateral severe ocular surface disease were chosen to undergo COMET on human AM. The primary outcome was clinical success, and the secondary outcomes were the best-corrected visual acuity difference, corneal opacification, symblepharon formation, and complications...
September 2016: Cell and Tissue Banking
https://www.readbyqxmd.com/read/27062561/evaluation-of-genotoxicity-of-general-anesthesia-maintained-with-desflurane-in-patients-under-minor-surgery
#11
Flávia R Nogueira, Leandro G Braz, Leonardo R de Andrade, Ana Lygia R de Carvalho, Luiz A Vane, Norma Sueli P Módolo, Aline G Aun, Kátina M Souza, José Reinaldo C Braz, Mariana G Braz
There is controversy over the genotoxic effects of volatile anesthetics. The available literature on the genotoxicity of desflurane, one of the newest volatile halogenated agents used for general anesthesia maintenance, is scarce. This study aimed to evaluate the genotoxic potential of desflurane in 15 patients without comorbidities, of both sexes, who underwent minor surgeries lasting at least 90 min. Patients enrolled in the study received desflurane anesthesia (6%); blood samples were collected before anesthesia induction (T0), 90 min after the beginning of anesthesia (T1), and on the day following surgery (T2)...
May 2016: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/26625730/a-core-outcome-set-for-all-types-of-cardiac-surgery-effectiveness-trials-a-study-protocol-for-an-international-edelphi-survey-to-achieve-consensus-on-what-to-measure-and-the-subsequent-selection-of-measurement-instruments
#12
MULTICENTER STUDY
A Moza, C Benstoem, R Autschbach, C Stoppe, A Goetzenich
BACKGROUND: Cardiovascular disease (CVD) is a major contributor to the burden of disease and the number one cause of death worldwide. From 1990 until today, more people died from coronary heart disease than from any other cause. CVD is regularly treated with minimally or non-minimally invasive off- or on-pump cardiothoracic surgery and several interventions related to the outcome of the surgical procedures have been evaluated in clinical trials, but heterogeneity in outcome reporting hinders comparison of interventions across trials and limits the ability of research synthesis...
2015: Trials
https://www.readbyqxmd.com/read/26604642/n-acetylcysteine-modulates-angiogenesis-and-vasodilation-in-stomach-such-as-dna-damage-in-blood-of-portal-hypertensive-rats
#13
Francielli Licks, Renata Minuzzo Hartmann, Camila Marques, Elizângela Schemitt, Josieli Raskopf Colares, Mariana do Couto Soares, Juliana Reys, Camila Fisher, Juliana da Silva, Norma Possa Marroni
AIM: To evaluate the antioxidant effect of N-acetylcysteine (NAC) on the stomach of rats with portal hypertension. METHODS: Twenty-four male Wistar rats weighing ± 250 g were divided into four experimental groups (n = 6 each): Sham-operated (SO), SO + NAC, partial portal vein ligation (PPVL), and PPVL + NAC. Treatment with NAC in a dose of 10 mg/kg (i.p.) diluted in 0.6 mL of saline solution was administered daily for 7 d starting 8 d after the surgery. Animals from the PPVL and SO group received saline solution (0...
November 21, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26496309/inflammatory-response-after-laparoscopic-versus-open-resection-of-colorectal-liver-metastases-data-from-the-oslo-comet-trial
#14
RANDOMIZED CONTROLLED TRIAL
Asmund Avdem Fretland, Andrey Sokolov, Nadya Postriganova, Airazat M Kazaryan, Soren E Pischke, Per H Nilsson, Ingrid Nygren Rognes, Bjorn Atle Bjornbeth, Morten Wang Fagerland, Tom Eirik Mollnes, Bjorn Edwin
Laparoscopic and open liver resection have not been compared in randomized trials. The aim of the current study was to compare the inflammatory response after laparoscopic and open resection of colorectal liver metastases (CLM) in a randomized controlled trial.This was a predefined exploratory substudy within the Oslo CoMet-study. Forty-five patients with CLM were randomized to laparoscopic (n = 23) or open (n = 22) resection. Ethylenediaminetetraacetic acid-plasma samples were collected preoperatively and at defined time points during and after surgery and snap frozen at -80 C...
October 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26451366/cultivated-oral-mucosa-epithelium-in-ocular-surface-reconstruction-in-aniridia-patients
#15
Dariusz Dobrowolski, Boguslawa Orzechowska-Wylegala, Bogumil Wowra, Ewa Wroblewska-Czajka, Maria Grolik, Krzysztof Szczubialka, Maria Nowakowska, Domenico Puzzolo, Edward A Wylegala, Antonio Micali, Pasquale Aragona
PURPOSE: Efficacy of cultivated oral mucosa epithelial transplantation (COMET) procedure in corneal epithelium restoration of aniridia patients. METHODS: Study subjects were aniridia patients (13 patients; 17 eyes) with irregular, vascular conjunctival pannus involving visual axis who underwent autologous transplantation of cultivated epithelium. For the procedure oral mucosa epithelial cells were obtained from buccal mucosa with further enzymatic treatment. Suspension of single cells was seeded on previously prepared denuded amniotic membrane...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26339365/cytologic-clinicopathologic-and-molecular-features-of-papillary-thyroid-carcinoma-with-prominent-hobnail-features-10-case-reports-and-systematic-literature-review
#16
REVIEW
Young Sub Lee, Yourha Kim, Sora Jeon, Ja Seong Bae, So Lyung Jung, Chan Kwon Jung
The hobnail variant of papillary thyroid carcinoma (PTC) is a rare, aggressive variant in which > 30% of the tumor cells have hobnail features. The clinical behavior and pathologic characteristics of these tumors are still unclear due to the rarity of the entity. The present study aimed to investigate cytologic, clinical, pathological, and molecular features of the hobnail variant from our data and from the literature. We retrospectively retrieved 10 cases of hobnail variant from 2,904 consecutive PTC patients...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26252290/isoflurane-and-propofol-contribute-to-increasing-the-antioxidant-status-of-patients-during-minor-elective-surgery-a-randomized-clinical-study
#17
RANDOMIZED CONTROLLED TRIAL
Mariana G Braz, Leandro G Braz, Cristiana M M Freire, Lorena M C Lucio, José R C Braz, Guangwen Tang, Daisy M F Salvadori, Kyung-Jin Yeum
Isoflurane is a volatile halogenated anesthetic used especially for anesthesia maintenance whereas propofol is a venous anesthetic utilized for anesthesia induction and maintenance, and reportedly an antioxidant. However, there are still controversies related to isoflurane-induced oxidative stress and it remains unanswered whether the antioxidant effects occur in patients under propofol anesthesia.Taking into account the importance of better understanding the role of anesthetics on oxidative stress in anesthetized patients, the present study was designed to evaluate general anesthesia maintained with isoflurane or propofol on antioxidant status in patients who underwent minimally invasive surgeries...
August 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26132566/the-effect-of-diagnostic-absorbed-doses-from-131i-on-human-thyrocytes-in-vitro
#18
Zbigniew Adamczewski, Mariusz Stasiołek, Bolesław Karwowski, Marek Dedecjus, Daria Orszulak-Michalak, Anna Merecz, Przemysław W Śliwka, Bartosz Puła, Andrzej Lewiński
BACKGROUND: Administration of diagnostic activities of 131I, performed in order to detect thyroid remnants after surgery and/or thyroid cancer recurrence/metastases, may lead to reduction of iodine uptake. This phenomenon is called "thyroid stunning". We estimated radiation absorbed dose-dependent changes in genetic material, in particular in sodium iodide symporter (NIS) gene promoter, and NIS protein level in human thyrocytes (HT). MATERIALS AND METHODS: We used unmodified HT isolated from patients subjected to thyroidectomy exposed to 131I in culture...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/25872027/open-versus-laparoscopic-liver-resection-for-colorectal-liver-metastases-the-oslo-comet-study-study-protocol-for-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Åsmund Avdem Fretland, Airazat M Kazaryan, Bjørn Atle Bjørnbeth, Kjersti Flatmark, Marit Helen Andersen, Tor Inge Tønnessen, Gudrun Maria Waaler Bjørnelv, Morten Wang Fagerland, Ronny Kristiansen, Karl Øyri, Bjørn Edwin
BACKGROUND: Laparoscopic liver resection is used in specialized centers all over the world. However, laparoscopic liver resection has never been compared with open liver resection in a prospective, randomized trial. METHODS/DESIGN: The Oslo-CoMet Study is a randomized trial into laparoscopic versus open liver resection for the surgical management of hepatic colorectal metastases. The primary outcome is 30-day perioperative morbidity. Secondary outcomes include 5-year survival (overall, disease-free and recurrence-free), resection margins, recurrence pattern, postoperative pain, health-related quality of life, and evaluation of the inflammatory response...
March 4, 2015: Trials
https://www.readbyqxmd.com/read/25720384/polyvinylidene-fluoride-as-a-suture-material-evaluation-of-comet-tail-like-infiltrate-and-foreign-body-granuloma
#20
COMPARATIVE STUDY
Andreas Lambertz, Kai Michael Schröder, Dominik Stefan Schöb, Marcel Binnebösel, Michael Anurov, Uwe Klinge, Ulf Peter Neumann, Christian Daniel Klink
BACKGROUND: Biocompatibility and tissue integration of a surgical suture are decisive factors for wound healing and therefore for the success of sutures. The optimal suture material is still under discussion. Polyvinylidene fluoride (PVDF) is described to have superior properties of biocompatibility and is therefore frequently used as a mesh component. Only little information is available about its use as a suture material. The aim of this study was to evaluate the biocompatibility of PVDF as a suture material in comparison to 5 different established sutures in a rat model...
2015: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
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