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Anti-aging Medicine

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https://www.readbyqxmd.com/read/29452298/treatment-and-outcomes-in-patients-with-igg4-related-disease-using-the-igg4-responder-index
#1
Andreu Fernández-Codina, Blanca Pinilla, Iago Pinal-Fernández, Cristina López, Guadalupe Fraile-Rodríguez, Eva Fonseca-Aizpuru, Iago Carballo, Pilar Brito-Zerón, Carlos Feijóo-Massó, Miguel López-Dupla, Maria Cinta Cid, Fernando Martínez-Valle
BACKGROUND: IgG4-related disease (IgG4-RD) is an autoimmune disease triggering an inflammatory cascade that leads to fibrosis. Outcome measures are limited and treatment options remain underexplored. OBJECTIVES: To assess the variation of the IgG4 responder index (IgG4-RI) in a cohort of IgG4-RD patients and to explore their treatments and outcomes. METHODS: We studied the clinical phenotype, severity of the disease and response to treatment in an ambispective multicenter cohort study including 14 different hospitals in Spain...
February 13, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29446818/heart-involvement-in-systemic-sclerosis
#2
Ihsen Zairi, Lilia Baili, Khadija Mzoughi, Manel Dridi, Zouhaier Jnifene, Fatma Boussema
INTRODUCTION: Primary and secondary heart involvement in systemic sclerosis are important mortality predictors. Aim of this study was to investigate by standard echocardiography associated to pulsed-tissue Doppler imaging, six-minute walk test (6MWT) and BNP level cardiac manifestation in 30 patients with ScS and to establish a strategy to detect and to evaluate this complication. METHODS: This was a cross-sectional study conducted over a period of 16 months: a total of 30 consecutive patients with ScS diagnosed as proposed by the American college of Rheumatology and the European League Against Rheumatism 2013 and who were hospitalized in Internal Medicine department of Habib Thameur hospital underwent cardiac assessment...
March 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29439346/chinese-herbal-medicine-for-vascular-dementia-a-systematic-review-and-meta-analysis-of-high-quality-randomized-controlled-trials
#3
Qing-Qing Xu, Chun-Shuo Shan, Yong Wang, Yi-Hua Shi, Qi-Hao Zhang, Guo-Qing Zheng
BACKGROUND: Vascular dementia (VaD) is the second common form of dementia and Chinese herbal medicine (CHM) has been used for aging-related disorders for thousands of years. However, there is still a lack of scientific evidence using CHM for VaD. OBJECTIVE: To conduct a systematic review to assess the current evidence available for the effectiveness and safety of CHM for VaD. METHODS: Six databases were searched for high-quality randomized-controlled clinical trials that met the requirements of at least 4 of the 7 domains of the Cochrane risk of bias tool from their inception to February 2017...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29431861/non-steroidal-anti-inflammatory-agents-to-induce-regression-and-prevent-the-progression-of-cervical-intraepithelial-neoplasia
#4
REVIEW
Shannon M Grabosch, Osman M Shariff, C William Helm
BACKGROUND: This is an updated version of the original Cochrane review published in 2014, Issue 4. Cervical intraepithelial neoplasia (CIN) precedes the development of invasive carcinoma of the cervix. Current treatment of CIN is quite effective, but there is morbidity for the patient related to pain, bleeding, infection, cervical stenosis and premature birth in a subsequent pregnancy. Effective treatment with medications, rather than surgery, would be beneficial. OBJECTIVES: To evaluate the effectiveness and safety of non-steroidal anti-inflammatory agents (NSAIDs), including cyclooxygenase-2 (COX-2) inhibitors, to induce regression and prevent the progression of CIN...
February 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29424183/-progress-on-rheumatoid-arthritis-in-elderly
#5
REVIEW
Xin Wang, Qin Zhao, Zhao-da Deng, Xiao-Yuan Wang, Si-Gong Zhang, Hai-Li Shen
During choosing non-steroidal anti-inflammatory drugs(NSAIDs), risk factors should be evaluated in elder patients with rheumatoid arthritis. The present study focused on biological therapies, and elderly patients should be more concerned about the risk of infection when used it. Traditional Chinese medicine has advantages of obvious curative effect, especially for tripterygium wilfordii, large clinical trial on western and Chinese medical accurate drug strategies for old patients with rheumatoid arthritis. Old patients are easier to suffer from cardiac diseases and interstitial lung disease, rheumatoid arthritis could be controlled along with the treatment for coexistent disease...
June 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29421930/research-and-development-of-anti-alzheimer-s-disease-drugs-an-update-from-the-perspective-of-technology-flows
#6
Kunmeng Liu, Hui-Heng Lin, Rongbiao Pi, Shinghung Mak, Yifan Han, Yuanjia Hu
Today, over 20 million people suffer from Alzheimer's disease (AD) worldwide. AD has become a critical issue to human health, especially in aging societies, and therefore it is a research hotspot in the global scientific community. The technology flow method differs from traditional reviews generating an informative overview of the research and development (R&D) landscape in a specific technological area. We need such an updated method to get a general overview of the R&D of anti-AD drugs in light of the dramatic developments in this area in recent years...
February 8, 2018: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/29411658/antioxidant-properties-and-anti-mutagenic-potential-of-piper-cubeba-fruit-extract-and-molecular-docking-of-certain-bioactive-compounds
#7
Maryam Zahin, Mohammad Shavez Khan, Faizan Abul Qais, Hussein Hasan Abulreesh, Iqbal Ahmad
Spices and herbs are recognized as sources of natural antioxidants and thus play an important role in the chemoprevention of diseases and aging. Piper cubeba is one among them and known for its medicinal properties for decades. Various biological activities are associated with its extract and phytocompounds. However, the anti-mutagenic activity of antioxidant rich extract is less explored. In this study, we performed the fraction-based antioxidant activity of P. cubeba using four different assays and evaluated the anti-mutagenic activity of most potent antioxidant fraction using Salmonella typhimurium tester strains against four mutagens (methyl methanesulfonate [MMS], sodium azide [SA], benzo(a)pyrene, and 2-aminoflourene) respectively...
February 7, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29411393/culturally-embedded-health-beliefs-self-care-and-the-use-of-anti-ageing-medicine-among-australian-and-japanese-older-adults
#8
Maho Omori, Deborah Dempsey
Adopting Kleinman's and Lock's ideas that there are cultural variations in understandings of health care and the medicalisation of ageing bodies, this study compares and contrasts older adults' use of anti-ageing medicine in two cultural settings. Based on 42 interviews conducted in Australia and Japan with adults aged 60 and over, findings revealed distinct pathways to initiating anti-ageing medicine use between the two cohorts which reflect different attitudes to the medicalisation of ageing in the two settings...
February 6, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29408763/multiple-pharmacological-activities-of-caesalpinia-crista-against-aluminium-induced-neurodegeneration-in-rats-relevance-for-alzheimer-s-disease
#9
Sunil K Ravi, Balenahalli Narasingappa Ramesh, Ravi Mundugaru, Bruno Vincent
Alzheimer's disease (AD) is the most common form of dementia and mainly affects cognitive function of the aged populations. Aluminium, a neurotoxic metal, has been suggested as a contributing factor of AD. Caesalpinia crista is a medicinal plant known for its anti-microbial, anti-inflammatory and anti-oxidant properties. The present study was conducted in order to evaluate the neuroprotective effects of methanolic extracts of C. crista (MECC) on aluminium-induced neurodegeneration in rats. Co-administration with MECC significantly and dose dependently ameliorated the aluminium-dependent cognitive impairment, AChE hyperactivity and oxidative stress in the hippocampus and in the frontal cortex of rat brain...
January 31, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29395886/-drug-administration-to-pediatric-patients-evaluation-of-the-nurses-preparation-habits-in-pediatric-units
#10
S Ménétré, M Weber, M Socha, S Le Tacon, I May, C Schweitzer, B Demoré
In hospitals, the nursing staff is often confronted with the problem of the preparation and administration of drugs for their pediatric patients because of the lack of indication, pediatric dosage, and appropriate galenic form. The goal of this study was to give an overview of the nurses' preparation habits in pediatric units and highlight their daily problems. This single-center prospective study was conducted through an observation of the nursing staff during the drug preparation process in medicine, surgery and intensive care units...
January 29, 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29389579/a-randomized-double-blind-clinical-study-of-the-effects-of-ankascin-568-plus-on-blood-lipid-regulation
#11
Sheng-Fu Liu, Yin-Ruei Wang, You-Cheng Shen, Chien-Li Chen, Chine-Ning Huang, Tzu-Ming Pan, Chin-Kun Wang
Hyperlipidemia and inflammation play important roles in the development and progression of atherosclerosis. Atherosclerosis is regarded as an inflammatory response of blood vessels to injury at the start of atherosclerotic plaque formation, which then leads to cardiovascular events. Edible fungi of the Monascus species have been used as traditional Chinese medicines in East Asia for several centuries. The fermented products of Monascus purpureus NTU 568 possess a number of functional secondary metabolites including the anti-inflammatory pigments monascin and ankaflavin...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29380708/technology-of-rna-interference-in-advanced-medicine
#12
Fatemeh Abedini, Mohammad Ebrahimi, Hossein Hosseinkhani
RNA interference (RNAi) and related pathways involving small interfering RNAs (siRNAs), microRNAs (miRNAs), and PIWI-interacting RNAs (piRNAs) regulate processes such as anti-viral defense, genome surveillance, heterochromatin formation, and gene expression in animals, plants, and fungi. Studies on RNAi have revealed a two-step mechanism: (i) Degradation of dsRNA into small interfering RNAs (siRNAs), 21 to 25 nucleotides long, by an RNase III-like activity. (ii) The siRNAs join an RNase complex, RISC (RNA-induced silencing complex), which acts on the mRNA and degrades it...
January 29, 2018: MicroRNA
https://www.readbyqxmd.com/read/29380024/nanofat-increases-dermis-thickness-and-neovascularization-in-photoaged-nude-mouse-skin
#13
Peng Xu, Qian Yu, Huizhen Huang, Wen Jie Zhang, Wei Li
OBJECT: To investigate the effects of nanofat injection into photoaged nude mouse skin on dermis thickness, neovascularization, and cell proliferation. METHODS: Adipose-derived stem cells (ADSCs) and nanofat were prepared from human liposuction aspirates. The photoaged skin model was created using ultraviolet B (UVB) radiation onto BALB/c nude mice. A total of 24 mice were used in this study; 6 mice without treatment (natural aging) served as controls, while 18 mice were irradiated under the UVB lamp and treated with PBS (200 μl per injection area), ADSCs (1 × 106/200 μl ADSCs per injection area), or nanofat (200 μl per injection area) on the dorsal skin...
January 29, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29378653/poly-herbal-formulation-with-anti-elastase-and-anti-oxidant-properties-for-skin-anti-aging
#14
Induja Kalyana Sundaram, Deepika Deeptirekha Sarangi, Vignesh Sundararajan, Shinomol George, Sahabudeen Sheik Mohideen
BACKGROUND: Skin forms an important part of human innate immune system. Wrinkles, thinning and roughening of skin are some of the symptoms that affect the skin as it ages. Reactive oxygen species induced oxidative stress plays a major role in skin aging by modulating the elastase enzyme level in the skin. Extrinsic factors that affect skin aging such as UV radiation can also cause malignant melanoma. Here we selected four medicinal plant materials, namely, leaves of Nyctanthes arbor-tristis, unripe and ripe Aegle marmelos fruit pulp and the terminal meristem of Musa paradisiaca flower and investigated their anti-aging properties and cytotoxicity in vitro individually as well as in a poly herbal formulation containing the four plant extracts in different ratios...
January 29, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29378470/prunella-vulgaris-l-exerts-a-protective-effect-against-extrinsic-aging-via-nf-%C3%AE%C2%BAb-mapks-ap-1-and-tgf-%C3%AE-smad-signaling-pathways-in-uvb-aged-normal-human-dermal-fibroblasts
#15
Mengyang Zhang, Eunson Hwang, Pei Lin, Wei Gao, Hien T T Ngo, Tae-Hoo Yi
Prunella vulgaris L., a well-known traditional Chinese herbal medicine, has anti-inflammatory and antioxidant activities. In the present study, the underlying molecular mechanisms of the protective effect of P. vulgaris extract (PVE) were investigated in UVB-irradiated normal human dermal fibroblasts (NHDFs). The mRNA expression of matrix metalloproteinases (MMPs), procollagen type I and cytokines such as interleukin-6 (IL-6) and tumor necrosis factor (TNF-α) was determined by RT-PCR. The expression of anti-photo aging-related signaling molecules in the NF-κB, MAPK/AP-1, and TGF/Smad pathways was assessed by Western blot...
January 29, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29371959/modulating-the-metabolism-by-trimetazidine-enhances-myoblast-differentiation-and-promotes-myogenesis-in-cachectic-tumor-bearing-c26-mice
#16
Lucia Gatta, Laura Vitiello, Stefania Gorini, Sergio Chiandotto, Paola Costelli, Anna Maria Giammarioli, Walter Malorni, Giuseppe Rosano, Elisabetta Ferraro
Trimetazidine (TMZ) is a metabolic reprogramming agent able to partially inhibit mitochondrial free fatty acid β-oxidation while enhancing glucose oxidation. Here we have found that the metabolic shift driven by TMZ enhances the myogenic potential of skeletal muscle progenitor cells leading to MyoD, Myogenin, Desmin and the slow isoforms of troponin C and I over-expression. Moreover, similarly to exercise, TMZ stimulates the phosphorylation of the AMP-activated protein kinase (AMPK) and up-regulates the peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC1α), both of which are known to enhance the mitochondrial biogenesis necessary for myoblast differentiation...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29370076/the-anti-stress-effect-of-mentha-arvensis-in-immobilized-rats
#17
Weishun Tian, Md Rashedunnabi Akanda, Anowarul Islam, Hae-Dong Yang, Sang-Cheon Lee, Jeong-Ho Lee, Sang-Ki Kim, Yu-Jin Choi, So-Yeon Im, Byung-Yong Park
Stress can lead to inflammation, accelerated aging, and some chronic diseases condition. Mentha arvensis (MA) is a traditional medicine having antioxidant and anti-inflammatory activities. The present study investigated the anti-stress role of MA and fermented MA (FMA) extract in immobilized rats. We studied the lipopolysaccharide (LPS)-induced inflammation in RAW 264.7 cells and rats were immobilized for 2 h per day for 14 days using a restraining cage. MA (100 mg/kg) and FMA (100 mg/kg) were orally administered to rats 1 h prior to immobilization...
January 25, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29369521/brief-challenges-on-medicinal-plants-an-eye-opening-look-at-ageing-related-disorders
#18
Geir Bjørklund, Maryam Dadar, Natália Martins, Salvatore Chirumbolo, Bey Hing Goh, Kateryna Smetanina, Roman Lysiuk
Several studies have reported that nature-derived antioxidants may prevent free radicals over-production and therefore control the onset and prevent the exacerbation of different kinds of diseases caused by oxidative stress and redox-derived stressors, including ageing, fundamentally by suppressing the oxidative byproducts-mediated degradation. Naturally derived antioxidants exert their anti-ageing action via a panoply of signalling systems, many of which engaging reactive oxygen (ROS) and nitrogen (RNS) species scavenging, with the Nrf2/Keap1-ARE system and improving the many survival genes and functions (such as the pathway mTOR/Foxo/SIRT1) able to slow cellular senescence...
January 25, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29355627/preparation-and-antioxidant-activities-of-important-traditional-plant-polysaccharides
#19
Yang Liu, Yuyang Sun, Gangliang Huang
Polysaccharides are widely found in nature, mainly divided into three kinds of plant polysaccharides, animal polysaccharides and microbial polysaccharides. In recent years, the antioxidant activity of polysaccharide has become a hot spot in the field of polysaccharide research. Polysaccharide is one of the active ingredients of many medicines, which has the functions of increasing antioxidant enzyme activity, eliminating free radicals, inhibiting lipid peroxidation and protecting the biofilm, anti-oxidation and anti-aging effects...
January 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29354613/the-clinical-effects-of-dendropanax-morbifera-on-postmenopausal-symptoms-review-article
#20
REVIEW
Mijin Kim, Yoo Jin Park, Hee-Sook Lim, Hae-Hyeog Lee, Tae-Hee Kim, Bora Lee
Postmenopausal women aged 50s generally experience gradual changes in body such as decline in antioxidant and estrogen levels as the body ages. To overcome these aging-associated changes, the needs for health functional foods are increasing. Dendropanax morbifera (DM) have antioxidant effects, anti-inflammatory against cancer cells, antidiabetic, and antiatherogenic effect which are associated with postmenopausal symptoms. We analyzed clinical effects of DM on aging-related symptoms by reporting their antioxidant, anticancer and inflammatory activity, etc...
December 2017: Journal of Menopausal Medicine
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