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https://www.readbyqxmd.com/read/28729684/combining-low-dimensional-wavelet-features-and-support-vector-machine-for-arrhythmia-beat-classification
#1
Qin Qin, Jianqing Li, Li Zhang, Yinggao Yue, Chengyu Liu
Automatic feature extraction and classification are two main tasks in abnormal ECG beat recognition. Feature extraction is an important prerequisite prior to classification since it provides the classifier with input features, and the performance of classifier depends significantly on the quality of these features. This study develops an effective method to extract low-dimensional ECG beat feature vectors. It employs wavelet multi-resolution analysis to extract time-frequency domain features and then applies principle component analysis to reduce the dimension of the feature vector...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719334/precisely-tracking-childhood-death
#2
Tamer H Farag, Jeffrey P Koplan, Robert F Breiman, Shabir A Madhi, Penny M Heaton, Trevor Mundel, Jaume Ordi, Quique Bassat, Clara Menendez, Scott F Dowell
Little is known about the specific causes of neonatal and under-five childhood death in high-mortality geographic regions due to a lack of primary data and dependence on inaccurate tools, such as verbal autopsy. To meet the ambitious new Sustainable Development Goal 3.2 to eliminate preventable child mortality in every country, better approaches are needed to precisely determine specific causes of death so that prevention and treatment interventions can be strengthened and focused. Minimally invasive tissue sampling (MITS) is a technique that uses needle-based postmortem sampling, followed by advanced histopathology and microbiology to definitely determine cause of death...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28718776/coil-geometry-effects-on-scanning-single-coil-magnetic-induction-tomography
#3
Joe R Feldkamp, Stephen Quirk
Alternative coil designs for single coil MIT (magnetic induction tomography) are considered in this work, with the intention of improving upon the standard design used previously. In particular, we note that the blind spot associated with this coil type, a portion of space along its axis where eddy current generation can be very weak, has an important effect on performance. The seven designs tested here vary considerably in the size of their blind spot. To provide the most discerning test possible, we use laboratory phantoms containing feature dimensions similar to blind spot size...
July 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28718185/congenital-pulmonary-lymphangiectasia-a-disorder-not-only-of-fetoneonates
#4
Shi-Min Yuan
Congenital pulmonary lymphangiectasia (CPL) is a rare developmental disorder of the lung, characterized by dilation of pulmonary subpleural, interlobar, perivascular and peribronchial lymphatics. The incidence of CPL among stillborn and neonates was estimated to be <1%. The etiology of CPL is unknown. However, it has been suspected to be of a genetic background. Recent basic studies revealed that it might be caused by the FOXC2, Vegfr-3 and integrin α9β1gene mutations. A clinical diagnosis of CPL can be made much easier in full-term neonates who present with respiratory distress, pleural (especially chylous) effusions with or without generalized edema...
July 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28715042/-diagnostic-significance-of-multiparametric-mri-combined-with-us-fusion-guided-biopsy-of-the-prostate-in-patients-with-increased-psa-levels-and-negative-standard-biopsy-results-to-detect-significant-prostate-cancer-correlation-with-the-gleason-score-korrelation
#5
Manuela Hoffmann, Manuela A Hoffmann, Helmut J Wieler, Frank M Jakobs, Kasra Taymoorian, Arnd Gerhards, Matthias Miederer, Mathias Schreckenberger
AIMS: To increase diagnostic precision and to reduce overtreatment of low-risk malignant disease, multiparametric MRI (mpMRI) combined with ultrasound (US) fusion guided biopsy of the prostate were performed. METHODS: In 99 male patients with increased PSA plasma levels and previous negative standard biopsy procedures, mpMRI was carried out followed by US fusion guided perineal biopsy. PI-RADS-Data (PS) of mpMRI and histopathological Gleason score (GS) were categorized and statistically compared...
July 17, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28713547/2017-iscb-innovator-award-aviv-regev
#6
EDITORIAL
Christiana N Fogg, Diane Kovats, Bonnie Berger
2017 marks the second year of the International Society for Computational Biology (ISCB) Innovator Award, which recognizes an ISCB scientist who is within two decades of having completed his or her graduate degree and has consistently made outstanding contributions to the field. The 2017 winner is Dr. Aviv Regev, Professor of Biology at the Massachusetts Institute of Technology (MIT), a Core Member and Chair of the Faculty of the Broad Institute of MIT and Harvard, and an HHMI Investigator. Regev will receive her award and deliver a keynote address during International Conference on Intelligent Systems for Molecular Biology/European Conference on Computational Biology (ISMB/ECCB) 2017 in Prague, Czech Republic (July 21 - 25, 2017)...
2017: F1000Research
https://www.readbyqxmd.com/read/28697553/impact-of-training-volume-and-intensity-on-rbc-nos-no-pathway-and-endurance-capacity
#7
Christina Koliamitra, Bastian Holtkamp, Philipp Zimmer, Wilhelm Bloch, Marijke Grau
BACKGROUND: Acute exercise increases red blood cell-nitric oxide synthase (RBC-NOS) activation and RBC deformability but the effect of regular training remains unclear. OBJECTIVE: To detect the chronic effect of enduring moderate and high intensity training on the RBC-NOS/NO pathway and to detect a relation between RBC deformability and endurance capacity. METHODS: 38 healthy male subjects were randomly assigned to one of three training groups: High Volume Training (HVT; 120-140 beats per minute (bpm)), High Intensity Training (HIT; 160-180 bpm) and Moderate Intensity Training (MIT; 140-160 bpm)...
July 3, 2017: Biorheology
https://www.readbyqxmd.com/read/28683225/book-review-extraordinary-science-and-psychiatry-responses-to-the-crisis-in-mental-health-research-extraordinary-science-and-psychiatry-responses-to-the-crisis-in-mental-health-research-poland-j-tekin-s-editors-cambridge-ma-mit-press-2017-327-p-us-50-cloth
#8
https://www.readbyqxmd.com/read/28677616/gas-sensors-based-on-molecular-imprinting-technology
#9
REVIEW
Yumin Zhang, Jin Zhang, Qingju Liu
Molecular imprinting technology (MIT); often described as a method of designing a material to remember a target molecular structure (template); is a technique for the creation of molecularly imprinted polymers (MIPs) with custom-made binding sites complementary to the target molecules in shape; size and functional groups. MIT has been successfully applied to analyze; separate and detect macromolecular organic compounds. Furthermore; it has been increasingly applied in assays of biological macromolecules. Owing to its unique features of structure specificity; predictability; recognition and universal application; there has been exploration of the possible application of MIPs in the field of highly selective gas sensors...
July 4, 2017: Sensors
https://www.readbyqxmd.com/read/28677193/akne
#10
Klaus Degitz, Falk Ochsendorf
Akne ist eine chronische Erkrankung mit hoher Prävalenz unter Jugendlichen. Pathogenetische Hauptfaktoren (und ihre klinischen Korrelate) sind gesteigerte Talgproduktion (Seborrhoe), follikuläre Hyperkeratose (Komedonen) und perifollikuläre Entzündungsvorgänge (Papulopusteln). Die Krankheit wird von endogenen (Androgene, IGF-1, neuroendokrine Faktoren) und exogenen (Propionibacterium acnes, Diät, mechanische Irritation, Inhaltsstoffe medizinischer oder kosmetischer Externa) Einflüssen moduliert. Akne geht mit zum Teil hoher Morbidität einher und kann bereits bei leichter Ausprägung eine erhebliche Verschlechterung der Lebensqualität bewirken...
July 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28677192/kongenitale-gef%C3%A3-%C3%A3-und-pigmentmale-mit-lymph%C3%A3-dem-beinl%C3%A3-ngendifferenz-und-skoliose
#11
Patricia Convalexius, Thomas A Luger, Markus Böhm
No abstract text is available yet for this article.
July 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28677189/radiosensibilisierung-durch-braf-inhibitoren
#12
Sophia Boyoung Strobel, Sylvie Pätzold, Lisa Zimmer, Alexandra Jensen, Alexander Enk, Jessica Cecile Hassel
HINTERGRUND: In der letzten Zeit wurden in der Literatur vermehrt erhöhte Hauttoxizitäten während einer Kombinationstherapie mit BRAF Inhibitoren und Radiotherapie beschrieben. MATERIAL UND METHODIK: Wir berichten über sieben Melanompatienten in einem nicht resezierbaren Stadium III oder IV, die eine kombinierte Behandlung aus Bestrahlung und BRAF-Inhibitor erhielten. ERGEBNISSE: Bei allen Patienten konnte durch die Kombinationstherapie ein gutes lokales Ansprechen erreicht werden...
July 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28677176/s1-leitlinie-lip%C3%A3-dem
#13
Stefanie Reich-Schupke, Wilfried Schmeller, Wolfgang Justus Brauer, Manuel E Cornely, Gabriele Faerber, Malte Ludwig, Gerd Lulay, Anya Miller, Stefan Rapprich, Dirk Frank Richter, Vivien Schacht, Klaus Schrader, Markus Stücker, Christian Ure
Die vorliegende überarbeitete Leitlinie zum Lipödem wurde unter der Federführung der Deutschen Gesellschaft für Phlebologie (DGP) erstellt und finanziert. Die Inhalte beruhen auf einer systematischen Literaturrecherche und dem Konsens von acht medizinischen Fachgesellschaften und Berufsverbänden. Die Leitlinie beinhaltet Empfehlungen zu Diagnostik und Therapie des Lipödems. Die Diagnose ist dabei auf der Basis von Anamnese und klinischem Befund zu stellen. Charakteristisch ist eine umschriebene, symmetrisch lokalisierte Vermehrung des Unterhautfettgewebes an den Extremitäten mit deutlicher Disproportion zum Stamm...
July 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28670564/comparison-of-mechanical-and-biological-properties-of-zirconia-and-titanium-alloy-orthodontic-micro-implants
#14
Hae Won Choi, Young Seok Park, Shin Hye Chung, Min Ho Jung, Won Moon, Sang Hoon Rhee
OBJECTIVE: The aim of this study was to compare the initial stability as insertion and removal torque and the clinical applicability of novel orthodontic zirconia micro-implants made using a powder injection molding (PIM) technique with those parameters in conventional titanium micro-implants. METHODS: Sixty zirconia and 60 titanium micro-implants of similar design (diameter, 1.6 mm; length, 8.0 mm) were inserted perpendicularly in solid polyurethane foam with varying densities of 20 pounds per cubic foot (pcf), 30 pcf, and 40 pcf...
July 2017: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/28669207/computational-psychiatry-new-perspectives-on-mental-illnessedited-by-a-david-redish-ph-d-and-joshua-a-gordon-m-d-ph-d-cambridge-mass-mit-press-2016-424-pp-45-00-hardcover
#15
Tali M Ball, Andrea N Goldstein-Piekarski
No abstract text is available yet for this article.
July 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28667007/the-ragd-gtpase-regulates-mtorc1-activity-to-promote-tumor-growth
#16
(no author information available yet)
MiT/TFE transcription factors directly upregulate RagD, which activates mTORC1 to support tumor growth.
June 30, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28666387/toolkit-for-the-construction-of-reproducing-kernel-based-representations-of-data-application-to-multidimensional-potential-energy-surfaces
#17
Oliver T Unke, Markus Meuwly
In the early days of computation, slow processor speeds limited the amount of data that could be generated and used for scientific purposes. In the age of big data, the limiting factor usually is the method with which large amounts of data are analyzed and useful information is extracted. A typical example from chemistry are high-level ab initio calculations for small systems, which have nowadays become feasible even if energies at many different geometries are required. Molecular dynamics simulations often require several thousand distinct trajectories to be run...
July 17, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28662816/premature-ventricular-contraction-detection-combining-deep-neural-networks-and-rules-inference
#18
Fei-Yan Zhou, Lin-Peng Jin, Jun Dong
Premature ventricular contraction (PVC), which is a common form of cardiac arrhythmia caused by ectopic heartbeat, can lead to life-threatening cardiac conditions. Computer-aided PVC detection is of considerable importance in medical centers or outpatient ECG rooms. In this paper, we proposed a new approach that combined deep neural networks and rules inference for PVC detection. The detection performance and generalization were studied using publicly available databases: the MIT-BIH arrhythmia database (MIT-BIH-AR) and the Chinese Cardiovascular Disease Database (CCDD)...
June 9, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28657821/a-scientific-approach-to-improve-physiological-capacity-of-an-elite-cyclist
#19
Bent R Rønnestad, Joar Hansen
Previous studies in endurance athletes has indicated that block periodization (BP) can be a good alternative to the more traditional organization of training despite the total volume and intensity of the training being similar. However, these studies usually last only 4-12 weeks. The aim of the present single-case study was to investigate the consequences of 58 weeks with systematic BP of low intensity training (LIT), moderate intensity training (MIT) and high intensity interval training (HIT) including incorporation of heavy strength training...
June 28, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28654923/antibakterielle-in-vitro-wirksamkeit-%C3%A3-therischer-%C3%A3-le-gegen-veterin%C3%A3-rmedizinisch-relevante-keime-klinischer-isolate-von-hunden-katzen-und-pferden
#20
Doris Bismarck, Marianne Schneider, Elisabeth Müller
Einleitung: Ätherische Öle sind die Grundlage der Aromatherapie. Unter anderem wird ihnen eine antibakterielle Wirkung zugeschrieben. In dieser Studie sollte die In-vitro-Wirksamkeit ätherischer Öle gegen ein breites Spektrum veterinärmedizinisch relevanter Erreger getestet werden. Methoden: Die antibakterielle Aktivität von 16 ätherischen Ölen wurde mittels Agardiffusionstest bestimmt. Getestet wurden grampositive und gramnegative Erreger, die aus klinischen Isolaten von Hunden, Katzen und Pferden aus der veterinärmedizinischen Routinediagnostik stammten...
2017: Complementary Medicine Research
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