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Kristen Severson, Brinda Monian, J Christopher Love, Richard D Braatz
Motivation: This work addresses two common issues in building classification models for biological or medical studies: learning a sparse model, where only a subset of a large number of possible predictors is used, and training in the presence of missing data. This work focuses on supervised generative binary classification models, specifically linear discriminant analysis (LDA). The parameters are determined using an expectation maximization algorithm to both address missing data and introduce priors to promote sparsity...
April 18, 2017: Bioinformatics
Mohannad Jabbar Mnati, Alex Van den Bossche, Raad Farhood Chisab
In this paper, a new smart voltage and current monitoring system (SVCMS) technique is proposed. It monitors a three phase electrical system using an Arduino platform as a microcontroller to read the voltage and current from sensors and then wirelessly send the measured data to monitor the results using a new Android application. The integrated SVCMS design uses an Arduino Nano V3.0 as the microcontroller to measure the results from three voltage and three current sensors and then send this data, after calculation, to the Android smartphone device of an end user using Bluetooth HC-05...
April 15, 2017: Sensors
Dong-Uk Park, Seung-Hun Ryu, Heung-Kyu Lim, Sun-Kyung Kim, Ye-Yong Choi, Jong-Ju Ahn, Eun Lee, Sang-Bum Hong, Kyung-Hyun Do, Jae-Lim Cho, Mun-Joo Bae, Dong-Chun Shin, Do-Myung Paek, Soo-Jong Hong
From 2002 through 2015, hundreds of people died of fatal lung injuries associated with the use of humidifier disinfectants (HDs) in Korea. Several chemical disinfectants used for household humidifiers were later clinically confirmed to cause HD-associated lung injury (HDLI). The aim of this study is to evaluate the registered lung disease cases and to compare the distribution of HDLI patients, including deaths, by HD use characteristics including types of HD and HD brands categorized by age group. A total of 530 registered were clinically examined through two rounds of investigations conducted from July 2013 until April 2015...
April 14, 2017: Science of the Total Environment
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Pneumologie
Xiaodong Huang, Kerrie Mengersen, Gabriel Milinovich, Wenbiao Hu
Background: The effects of weather variability on seasonal influenza among different age groups remain unclear. Objectives: The comparative study aims to explore the differences in the associations between weather variability and seasonal influenza, and growth rates of seasonal influenza epidemics among different age groups in Queensland, Australia. Methods: Three Bayesian spatiotemporal conditional autoregressive models were fitted at postal area level to quantify the relationships between seasonal influenza and monthly minimum temperature (MIT), monthly vapour pressure (VAP), school calendar pattern and Index of Relative Socio-Economic Advantage and Disadvantage for three age groups (<15, 15-64 and 65+ years)...
April 12, 2017: Journal of Infectious Diseases
Carlos Horro, Martin Cook, Teresa K Attwood, Michelle D Brazas, John M Hancock, Patricia Palagi, Manuel Corpas, Rafael Jimenez
Summary: The vast, uncoordinated proliferation of bioinformatics resources (databases, software tools, training materials, etc .) makes it difficult for users to find them. To facilitate their discovery, various services are being developed to collect such resources into registries. We have developed BioCIDER, which, rather like online shopping 'recommendations', provides a contextualisation index to help identify biological resources relevant to the content of the sites in which it is embedded...
April 12, 2017: Bioinformatics
Duško Odić, Jana Prah, Gorazd Avguštin
The aim of this study was to analyze the bacterial community in the production line of a calcium carbonate filler production company and to investigate possible causes for bacterial presence. Throughout 2012, 24 carbonate slurry and six groundwater samples were analyzed. Pseudomonas and Microbacterium were the most frequent contaminants in the slurry, whereas Pseudomonas and Brevundimonas dominated the groundwater samples. Of the 43 different bacterial strains isolated, only five were found both in the slurry and the groundwater, indicating that the latter was not a major source of contamination...
April 2017: Biofouling
José Fernández Navarro, Joel Sjöstrand, Fredrik Salmén, Joakim Lundeberg, Patrik L Ståhl
Motivation: In recent years we have witnessed an increase in novel RNA-seq based techniques for transcriptomics analysis. Spatial transcriptomics is a novel RNA-seq based technique that allows spatial mapping of transcripts in tissue sections. The spatial resolution adds an extra level of complexity, which requires the development of new tools and algorithms for efficient and accurate data processing. Results: Here we present a pipeline to automatically and efficiently process RNA-seq data obtained from spatial transcriptomics experiments to generate datasets for downstream analysis...
April 7, 2017: Bioinformatics
Jing-Min Wang, Ming-Ta Yang, Po-Lin Chen
With the advance of science and technology, people have a desire for convenient and comfortable living. Creating comfortable and healthy indoor environments is a major consideration for designing smart homes. As handheld devices become increasingly powerful and ubiquitous, this paper proposes an innovative use of smart handheld devices (SHD), using MIT App Inventor and fuzzy control, to perform the real-time monitoring and smart control of the designed intelligent windowsill system (IWS) in a smart home. A compact weather station that consists of environment sensors was constructed in the IWS for measuring of indoor illuminance, temperature-humidity, carbon dioxide (CO₂) concentration and outdoor rain and wind direction...
April 11, 2017: Sensors
Luca Mesin
BACKGROUND AND OBJECTIVE: Heartbeats Holter monitoring is important for the detection of arrhythmias and possible anomalies, which are predictive of cardiovascular risks and infections. Reducing the number of acquired samples is useful to save energy and memory, but a proper down-sampling schedule is needed to record all useful information. Method An adaptive algorithm for the non-uniform down-sampling of data is used to reduce the mean sampling frequency of ECG data. The acquired data are processed to extract RR rhythm and to classify the heartbeats among a set of possible types of arrhythmias...
March 30, 2017: Computers in Biology and Medicine
Agustin España, Pilar Iranzo, Josep Herrero-González, José M Mascaro, Ricardo Suárez
HINTERGRUND UND ZIELE: Es gibt nur wenige Berichte zur Beteiligung der okulären/periokulären Region beim Pemphigus vulgaris (PV). Ziel der vorliegenden Studie war es, das Krankheitsbild des okulären PV (OPV) zu untersuchen und seinen prognostischen Wert zu definieren. PATIENTEN UND METHODIK: Zwischen 1985 und 2014 wurden insgesamt 167 Patienten mit Pemphigus vulgaris an vier tertiären spanischen Krankenhäusern behandelt. Wir haben alle Patienten mit OPV in diese retrospektive Studie aufgenommen...
April 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Stefan Esser, Judith Krotzek, Henrike Dirks, Norbert Scherbaum, Dirk Schadendorf
HINTERGRUND: Steigende Inzidenzen von HIV-Infektionen und STIs (sexually transmitted infections) bei MSM (men having sex with men) seit 2001 in Deutschland erfordern neue Ansätze in der ärztlichen Präventionsarbeit. Diese Studie befasst sich mit geeigneten Parametern für gezielte ärztliche Angebote an HIV-positive MSM mit hohem Risiko für die Übertragung von HIV und STIs. METHODIK UND PATIENTEN: In einem zweijährigen Beobachtungszeitraum wurden 233 HIV-positive MSM in der HIV-Ambulanz des Universitätsklinikums Essen zu ihrem Sexualverhalten, Suchtmittelkonsum und psychischem Befinden im vorhergehenden Jahr systematisch befragt...
April 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Werner Kempf, Christina Mitteldorf, Laszlo J Karai, Alistair Robson
Die lymphomatoide Papulose (LYP) ist klinisch durch rezidivierende papulonoduläre Läsionen charakterisiert. Im Gegensatz zu dieser stereotypen klinischen Präsentation zeigt die Erkrankung ein breites histologisches Spektrum mit verschiedenen Infiltratmustern, unterschiedlichen Tumorzellgrößen und variablen Phänotypen. Die revidierte WHO-Klassifikation 2016 umfasst die histologischen LYP-Typen A bis E und einen sechsten Typ, dem eine spezielle Mutation zugrunde liegt. Darüber hinaus werden jedoch immer wieder neue Typen vorgeschlagen, wobei sich die Ausweitung nicht ausschließlich auf histologische Muster bezieht, sondern sich auch auf klinische und genetische Aspekte ausdehnt...
April 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Nina Trenkler, Christine Fink, Andreas Epple, Ferdinand Toberer, Alexander Enk, Holger A Haenssle
No abstract text is available yet for this article.
April 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
Marta Ulusoy, Peter Borusiak, Karin A Hameister, Max Geraedts
The question of a possible presence of attention deficit/hyperactivity disorder (ADHD) is raised with increasing frequency in pediatric practice. There are guidelines and expert recommendations for diagnostic approaches. But there are no instruments available to evaluate the structural, process and outcome quality. In this pilot study, a set of quality indicators on the treatment quality of ADHD was analyzed in terms of their feasibility in tertiary referral centers.A set of 39 quality indicators (QI) on ADHD developed in advance in a multistage procedure was assessed at 9 tertiary referral centers, with a focus on process verifiability and feasibility...
April 3, 2017: Das Gesundheitswesen
Johannes Maria Wolff
Abirateronacetat, das in Kombination mit Prednison/Prednisolon verabreicht wird, spielt eine wichtige Rolle in der Therapie des metastasierten kastrationsresistenten Prostatakarzinoms. Im Folgenden wurden besondere Aspekte der Therapie im klinischen Alltag zusammengestellt. Sie betreffen unter anderem die Dosierung - auch vor dem Hintergrund der Markteinführung einer neuen Formulierung von Abirateronacetat. Hinzu kommt die Verträglichkeit, vor allem in Bezug auf kardiovaskuläre und Kortikoid-bedingte Nebenwirkungen...
2017: Oncology Research and Treatment
Jürgen E Gschwend
Die Erstlinientherapie des nicht oder mild symptomatischen metastasierten kastrationsresistenten Prostatakarzinoms erfolgt heute vermehrt mit dem Androgen-Biosynthese-Inhibitor Abirateronacetat plus Prednison/Prednisolon oder dem Androgenrezeptor-Signalweg-Inhibitor Enzalutamid. Diese modernen antihormonellen Wirkstoffe konnten in den jeweiligen Zulassungsstudien bei insgesamt guter Verträglichkeit das Überleben der Patienten signifikant verlängern. Im Folgenden wird ein Überblick über weitere aktuelle Daten in Bezug auf die Erstlinientherapie gegeben...
2017: Oncology Research and Treatment
David Pfister
In der Entwicklung des Prostatakarzinoms spielen Androgene und der Androgenrezeptor eine zentrale Rolle. Über Jahrzehnte war die konventionelle Androgendeprivationstherapie (ADT) die wichtigste Behandlungsoption im metastasierten Stadium. Trotz initialen Ansprechens auf eine ADT entwickelt sich im Verlauf in der Regel ein metastasiertes kastrationsresistentes Prostatakarzinom (mCRPC). Für dieses Stadium gab es jahrelang keine Therapie, für die eine Verlängerung des Überlebens gezeigt werden konnte. Dies änderte sich erst 2004 mit der Studie TAX 327 zur Wirksamkeit von Docetaxel...
2017: Oncology Research and Treatment
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