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https://www.readbyqxmd.com/read/29444205/ssbio-a-python-framework-for-structural-systems-biology
#1
Nathan Mih, Elizabeth Brunk, Ke Chen, Edward Catoiu, Anand Sastry, Erol Kavvas, Jonathan M Monk, Zhen Zhang, Bernhard O Palsson, Alfonso Valencia
Summary: Working with protein structures at the genome-scale has been challenging in a variety of ways. Here, we present ssbio, a Python package that provides a framework to easily work with structural information in the context of genome-scale network reconstructions, which can contain thousands of individual proteins. The ssbio package provides an automated pipeline to construct high quality genomescale models with protein structures (GEM-PROs), wrappers to popular third-party programs to compute associated protein properties, and methods to visualize and annotate structures directly in Jupyter notebooks, thus lowering the barrier of linking 3D structural data with established systems workflows...
February 12, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29425273/kpax3-bayesian-bi-clustering-of-large-sequence-datasets
#2
Alberto Pessia, Jukka Corander, Bonnie Berger
Motivation: Estimation of the hidden population structure is an important step in many genetic studies. Often the aim is also to identify which sequence locations are the most discriminative between groups of samples for a given data partition. Automated discovery of interesting patterns that are present in the data can help to generate new biological hypotheses. Results: We introduce Kpax3, a Bayesian method for bi-clustering multiple sequence alignments. Influence of individual sites will be determined in a supervised manner by using informative prior distributions for the model parameters...
February 7, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29418109/pruritische-papulovesikul%C3%A3-se-dermatose-mit-retikul%C3%A3-rer-hyperpigmentierung
#3
Victor Olsavszky, Cyrill Géraud
No abstract text is available yet for this article.
February 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29418108/hautfarbene-papeln-an-den-ellenbogen-mit-granuloma-anulare-%C3%A3-hnlichem-histologischen-muster
#4
Julia Liersch, Christina Rohdenburg, Carla Duckheim, Jörg Schaller
No abstract text is available yet for this article.
February 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29418106/biosimilars-in-der-dermatologie%C3%A2-theorie-wird-realit%C3%A3-t
#5
REVIEW
Sascha Gerdes, Ulrich Mrowietz, Matthias Augustin, Ralph von Kiedrowski, Alexander Enk, Klaus Strömer, Michael P Schön, Marc A Radtke
Biosimilars sind biologische Medikamente, bei denen es sich um Nachbildungen eines spezifischen Referenzprodukts handelt. Biosimilars der Tumornekrosefaktor-alpha-Inhibitoren Infliximab und Etanercept sind bereits zugelassen und stehen für dermatologische Indikationen zur Verfügung. Die Aufsichtsbehörden verlangen eine eingehende Analyse der physikochemischen und funktionellen Eigenschaften dieser hochkomplexen Moleküle sowie klinische Daten hinsichtlich ihrer gleichwertigen Wirksamkeit und Sicherheit anhand mindestens einer klinischen Studie mit einer sensitiven und homogenen Population...
February 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29418100/molekulare-diagnostik-von-hautinfektionen-am-paraffinmaterial-%C3%A3-bersicht-und-interdisziplin%C3%A3-rer-konsensus
#6
REVIEW
Cord Sunderkötter, Karsten Becker, Heinz Kutzner, Thomas Meyer, Norbert Blödorn-Schlicht, Udo Reischl, Pietro Nenoff, Walter Geißdörfer, Yvonne Gräser, Mathias Herrmann, Joachim Kühn, Christian Bogdan
Nukleinsäure-Amplifikations-Techniken (NAT), wie die PCR, sind hochsensitiv sowie selektiv und stellen in der mikrobiologischen Diagnostik wertvolle Ergänzungen zur kulturellen Anzucht und Serologie dar. Sie bergen aber gerade bei formalinfixiertem und in Paraffin eingebettetem Gewebe ein Risiko für sowohl falsch negative als auch falsch positive Resultate, welches nicht immer richtig eingeschätzt wird. Daher haben Vertreter der Deutschen Gesellschaft für Hygiene und Mikrobiologie (DGHM) und der Deutschen Dermatologischen Gesellschaft (DDG) einen Konsensus in Form einer Übersichtsarbeit erarbeitet, wann eine NAT am Paraffinschnitt angezeigt und sinnvoll ist und welche Punkte dabei in der Präanalytik und Befundinterpretation beachtet werden müssen...
February 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29418099/elastolysen-und-hauterkrankungen-mit-verlust-der-elastischen-fasern
#7
Michael Tronnier
Die elastischen Fasern sind neben den kollagenen Fasern der wichtigste Bestandteil des Bindegewebsgerüstes der Haut. Eine Verminderung oder ein Verlust der elastischen Fasern ist bei einer Vielzahl von klinisch sich unterschiedlich präsentierenden Erkrankungen, hereditär oder erworben, beschrieben. Bei den Erkrankungen, die mit einer Entzündung einhergehen ist die Elastophagozytose ein wichtiges histologisches Merkmal. Die Therapie der Erkrankungen dieser Gruppe ist grundsätzlich schwierig.
February 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29418093/spalthauttransplantation-zur-defektdeckung-am-ohr-eine-statistische-analyse
#8
Tobias Thuile, Lorenz Larcher, Barbara Gatscher, Karl Schwaiger, Jenny Deluca, Amgiad Fallaha, Lukas Tappeiner, Mario Puviani, Klaus Eisendle
HINTERGRUND UND ZIELE: Die Rekonstruktion nach Entfernung ausgedehnter maligner Hauttumoren am Ohr ist eine Herausforderung. Verschiedene Methoden der Defektdeckung wurden beschrieben. Lappenplastiken, längere Anästhesiezeiten, geringe Compliance und Antikoagulation stellen bei den oft älteren Patienten zusätzliche Risiken dar. Eine rasch, effizient und unkompliziert durchführbare Methode der Defektdeckung ist daher wünschenswert. Ziel der Studie war die Beurteilung des ästhetischen Resultats, des Heilungsprozesses, der Komplikations- und Rezidivrate nach Transplantation ungenetzter Spalthaut (SPHT) zur Defektdeckung nach knorpelerhaltender Resektion maligner Tumoren am Ohr...
February 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29418087/erythemat%C3%A3-se-and-hypopigmentierte-streifen-mit-atrophie-entlang-der-blaschko-linien
#9
Cheng Tan, Yan-Ning Xue, Zhong-Sheng Min
No abstract text is available yet for this article.
February 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29414131/steven-e-hyman
#10
Steven E Hyman
Interview with Steven Hyman, Director of the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard.
January 8, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29411062/aerogel-from-chemo-enzymatically-oxidized-fenugreek-gum-an-innovative-delivery-system-of-isothiazolinones-biocides
#11
Tiziana Silvetti, Luca Merlini, Milena Brasca, Yves M Galante
Aerogels of chemo-enzymatically oxidized, lyophilized fenugreek gum (EOLFG) were evaluated as "delivery system" (DS) of the microbiocide mix 5-chloro-2-methyl-4-isothiazolin-3-one (CIT) and 2-methyl-4-isothiazolin-3-one (MIT). These biocides have a broad activity spectrum and a low MIC (minimal inhibitory concentration) in the ppm range. They are approved under the EU Biocidal Product Directive for various applications, including cosmetics, are classified as skin sensitizers, and are under increasing scrutiny to limit or eliminate their use...
February 6, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29402881/tunable-metal-insulator-transition-rashba-effect-and-weyl-fermions-in-a-relativistic-charge-ordered-ferroelectric-oxide
#12
Jiangang He, Domenico Di Sante, Ronghan Li, Xing-Qiu Chen, James M Rondinelli, Cesare Franchini
Controllable metal-insulator transitions (MIT), Rashba-Dresselhaus (RD) spin splitting, and Weyl semimetals are promising schemes for realizing processing devices. Complex oxides are a desirable materials platform for such devices, as they host delicate and tunable charge, spin, orbital, and lattice degrees of freedoms. Here, using first-principles calculations and symmetry analysis, we identify an electric-field tunable MIT, RD effect, and Weyl semimetal in a known, charge-ordered, and polar relativistic oxide Ag2BiO3 at room temperature...
February 5, 2018: Nature Communications
https://www.readbyqxmd.com/read/29394053/selective-vapor-pressure-dependent-proton-transport-in-a-metal-organic-framework-with-two-distinct-hydrophilic-pores
#13
Sarah S Park, Adam J Rieth, Christopher Hendon, Mircea Dinca
The mechanism of proton conductivity in porous solids (i.e. Grotthuss or vehicular) is related to the structure and chemical environment of the pores. Direct observation of structure-function relationships is difficult because state-of-the-art solid proton conductors are often amorphous. Here, we present a systematic elucidation of two distinct proton transport pathways within MIT-25, a mesoporous metal-organic framework that exhibits parallel channels of ~27 Å and ~4.5 Å width. We characterize transport through these pores using temperature- and humidity-dependent proton conductivity measurements and density functional theory...
February 2, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29389907/a-sleep-questionnaire-for-children-with-severe-psychomotor-impairment-snake-concordance-with-a-global-rating-of-sleep-quality
#14
Larissa Alice Dreier, Boris Zernikow, Markus Blankenburg, Julia Wager
Sleep problems are a common and serious issue in children with life-limiting conditions (LLCs) and severe psychomotor impairment (SPMI). The "Sleep Questionnaire for Children with Severe Psychomotor Impairment" (Schlaffragebogen für Kinder mit Neurologischen und Anderen Komplexen Erkrankungen, SNAKE) was developed for this unique patient group. In a proxy rating, the SNAKE assesses five different dimensions of sleep(-associated) problems (disturbances going to sleep, disturbances remaining asleep, arousal and breathing disorders, daytime sleepiness, and daytime behavior disorders)...
February 1, 2018: Children
https://www.readbyqxmd.com/read/29384139/highly-selective-and-sensitive-methanol-gas-sensor-based-on-molecular-imprinted-silver-doped-lafeo3-core-shell-and-cage-structures
#15
Qian Rong, Yumin Zhang, Tianping Lv, Kaiyuan Shen, Baoye Zi, Zhongqi Zhu, Ji Zhang, Q J Liu
Silver-doped LaFeO3 molecularly imprinted polymers (SLMIPs) were synthesized by a sol gel method combined with molecularly imprinted technology (MIT) as precursors. The precursors were then used to prepare SLMIPs cage (SLM-cage) and SLMIPs core-shell (SLM-core-shell) structures by using a carbon sphere as template and hydrothermal synthesis, respectively. The structures, morphologies, and surface areas of these materials were determined, as well as their gas-sensing properties and related mechanisms. The SLM-cage and SLM-core-shell samples exhibited good responses to methanol gas, with excellent selectivity...
January 31, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29382740/a-plastidial-pantoate-transporter-with-a-potential-role-in-pantothenate-synthesis
#16
Lili Huang, Michal Pyc, Saleh Alseekh, Donald R McCarty, Valérie de Crécy-Lagard, Jesse F Gregory, Christopher S Henry, Alisdair R Fernie, Robert T Mullen, Andrew D Hanson
The pantothenate (vitamin B5) synthesis pathway in plants is not fully defined because the sub-cell-ular site of its ketopantoate → pantoate reduction step is unclear. However, the pathway is known to be split between cytosol, mit-o-chondria, and potentially plastids, and inferred to involve mitochondrial or plast-idial transport of ketopantoate or pantoate. No proteins that mediate these transport steps have been identified. Compar-at-ive genomic and transcriptomic analyses identified Arabidopsis thal-iana BASS1 (At1g78560) and its maize ( Zea mays ) ortholog as candidates for such a transport role...
January 30, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29378580/automatic-qrs-complex-detection-using-two-level-convolutional-neural-network
#17
Yande Xiang, Zhitao Lin, Jianyi Meng
BACKGROUND: The QRS complex is the most noticeable feature in the electrocardiogram (ECG) signal, therefore, its detection is critical for ECG signal analysis. The existing detection methods largely depend on hand-crafted manual features and parameters, which may introduce significant computational complexity, especially in the transform domains. In addition, fixed features and parameters are not suitable for detecting various kinds of QRS complexes under different circumstances. METHODS: In this study, based on 1-D convolutional neural network (CNN), an accurate method for QRS complex detection is proposed...
January 29, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29377848/metacognitive-interpersonal-therapy-for-personality-disorders-featuring-emotional-inhibition-a-multiple-baseline-case-series
#18
Keely Gordon-King, Robert D Schweitzer, Giancarlo Dimaggio
Metacognitive interpersonal therapy (MIT) is an integrative psychotherapeutic approach targeting personality disorders (PDs) featuring inhibition and avoidance. The current case series reports the outcome of a time-limited, 12-month MIT intervention for people with PDs featuring emotional inhibition. Seven participants were diagnosed with a PD on the basis of a structured clinical interview. The study followed a multiple baseline design, with baseline measures taken for 3 weeks before intervention. Participants underwent 12 months of weekly MIT sessions, with outcome measures taken every 3 months...
January 27, 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29372641/enhanced-metal-insulator-transition-performance-in-scalable-vanadium-dioxide-thin-films-prepared-using-a-moisture-assisted-chemical-solution-approach
#19
Weizheng Liang, Min Gao, Chang Lu, Zhi Zhang, Cheuk Ho Chan, Lanjian Zhuge, Ji-Yan Dai, Hao Yang, Chonglin Chen, Bae Ho Park, Quanxi Jia, Yuan Lin
Vanadium dioxide (VO2) is a strong-correlated metal-oxide with a sharp metal-insulator transition (MIT) for broad device development. However, synthesizing epitaxial VO2 films with desired properties has been a challenge due to the difficulty in controlling the oxygen stoichiometry of VOx, where x can be in the range of 1< x <2.5 and V has multiple valence states. Herein, a unique moisture-assisted chemical solution approach has been developed to successfully manipulate the oxygen stoichiometry, to significantly broaden the growth window, and to significantly enhance the MIT performance of VO2 films...
January 26, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29366938/a-compact-portable-re-configurable-and-automated-system-for-on-demand-pharmaceutical-tablet-manufacturing
#20
Mohammad A Azad, Juan G Osorio, David Brancazio, Gregory Hammersmith, David M Klee, Kersten Rapp, Allan Myerson
Due to the complex nature of the pharmaceutical supply chain, the industry faces several major challenges when it comes to ensuring an adequate supply of quality drug products. These challenges are not only the causes of supply chain disruptions and financial loss, but can also prevent underserved and remote areas from receiving life-saving drugs. As a preliminary demonstration to mitigate all these challenges, at MIT we have developed active pharmaceutical ingredients manufacturing in a miniature platform...
January 20, 2018: International Journal of Pharmaceutics
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