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https://www.readbyqxmd.com/read/28640829/an-exploration-of-collaborative-scientific-production-at-mit-through-spatial-organization-and-institutional-affiliation
#1
Matthew Claudel, Emanuele Massaro, Paolo Santi, Fiona Murray, Carlo Ratti
Academic research is increasingly cross-disciplinary and collaborative, between and within institutions. In this context, what is the role and relevance of an individual's spatial position on a campus? We examine the collaboration patterns of faculty at the Massachusetts Institute of Technology, through their academic output (papers and patents), and their organizational structures (institutional affiliation and spatial configuration) over a 10-year time span. An initial comparison of output types reveals: 1...
2017: PloS One
https://www.readbyqxmd.com/read/28637077/-tracheostomy-home-care-of-patients-after-long-term-ventilation-on-the-icu-a-position-paper
#2
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28636821/insight-into-electronic-and-structural-reorganizations-for-defect-induced-vo2-metal-insulator-transition
#3
Xijun Wang, Zhaowu Wang, Guozhen Zhang, Jun Jiang
Oxygen vacancy defect in monoclinic VO2 has been shown to modulate the metal-insulator transition (MIT) at room temperature. However, as the electronic and structural reorganizations occur simultaneously, the origin of MIT is still unclear. Here we performed first-principles calculations to examine electronic variations separately from structural reorganizations during MIT. It is found that oxygen defect induces electronic reorganization by creating polarized 3d-orbitial electrons, while structure reorganization makes the conduction band edge states available for occupation...
June 21, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28624712/classification-of-ecg-heartbeats-using-nonlinear-decomposition-methods-and-support-vector-machine
#4
Kandala N V P S Rajesh, Ravindra Dhuli
Classifying electrocardiogram (ECG) heartbeats for arrhythmic risk prediction is a challenging task due to minute variations in the amplitude, duration and morphology of the ECG signal. In this paper, we propose two feature extraction approaches to classify five types of heartbeats: normal, premature ventricular contraction, atrial premature contraction, left bundle branch block and right bundle branch block. In the first approach, ECG beats are decomposed into intrinsic mode functions (IMFs) using ensemble empirical mode decomposition (EEMD)...
June 15, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28622760/fawcett-j-m-risko-e-f-kingstone-a-eds-the-handbook-of-attention-fawcett-j-m-risko-e-f-kingstone-a-eds-the-handbook-of-attention-cambridge-ma-usa-mit-press-2015-696-pp-isbn-9780262029698-%C3%A2-57-95-hardcover
#5
https://www.readbyqxmd.com/read/28620839/probability-density-distribution-of-delta-rr-intervals-a-novel-method-for-the-detection-of-atrial-fibrillation
#6
Yanjun Li, Xiaoying Tang, Ancong Wang, Hui Tang
Atrial fibrillation (AF) monitoring and diagnosis require automatic AF detection methods. In this paper, a novel image-based AF detection method was proposed. The map was constructed by plotting changes of RR intervals (△RR) into grid panes. First, the map was divided into grid panes with 20 ms fixed resolution in y-axes and 15-60 s step length in x-axes. Next, the blank pane ratio (BPR), the entropy and the probability density distribution were processed using linear support-vector machine (LSVM) to classify AF and non-AF episodes...
June 15, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28619945/transcriptional-activation-of-ragd-gtpase-controls-mtorc1-and-promotes-cancer-growth
#7
Chiara Di Malta, Diletta Siciliano, Alessia Calcagni, Jlenia Monfregola, Simona Punzi, Nunzia Pastore, Andrea N Eastes, Oliver Davis, Rossella De Cegli, Angela Zampelli, Luca G Di Giovannantonio, Edoardo Nusco, Nick Platt, Alessandro Guida, Margret Helga Ogmundsdottir, Luisa Lanfrancone, Rushika M Perera, Roberto Zoncu, Pier Giuseppe Pelicci, Carmine Settembre, Andrea Ballabio
The mechanistic target of rapamycin complex 1 (mTORC1) is recruited to the lysosome by Rag guanosine triphosphatases (GTPases) and regulates anabolic pathways in response to nutrients. We found that MiT/TFE transcription factors-master regulators of lysosomal and melanosomal biogenesis and autophagy-control mTORC1 lysosomal recruitment and activity by directly regulating the expression of RagD. In mice, this mechanism mediated adaptation to food availability after starvation and physical exercise and played an important role in cancer growth...
June 16, 2017: Science
https://www.readbyqxmd.com/read/28606466/hip-rate-of-force-development-and-strength-are-impaired-in-females-with-patellofemoral-pain-without-signs-of-altered-gluteus-medius-and-maximus-morphology
#8
Guilherme S Nunes, Christian John Barton, Fábio Viadanna Serrão
OBJECTIVES: To compare rate of force development (RFD) and isometric muscle strength of the hip abductors and extensors; and the thickness and the amount of non-contractile tissue of the gluteus medius and maximus between females with and without patellofemoral pain (PFP). DESIGN: Cross-sectional study. METHODS: Fifty-four physically active females (27 with PFP and 27 healthy individuals) were studied. Hip muscle isometric strength and RFD was evaluated using isokinetic dynamometry...
May 24, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28605460/modmaps3d-an-interactive-webtool-for-the-quantification-and-3d-visualization-of-interrelationships-in-a-dataset-of-dna-sequences
#9
Rallis Karamichalis, Lila Kari
Summary: MoDMaps3D (Molecular Distance Maps 3D) is an alignment-free, fast, computationally lightweight webtool for computing and visualizing the interrelationships within any dataset of DNA sequences, based on pairwise comparisons between their oligomer compositions. MoDMaps3D is a general-purpose interactive webtool that is free of any requirements on sequence composition, position of the sequences in their respective genomes, presence or absence of similarity or homology, sequence length, or even sequence origin (biological or computer-generated)...
June 10, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28605449/fqc-dashboard-integrates-fastqc-results-into-a-web-based-interactive-and-extensible-fastq-quality-control-tool
#10
Joseph Brown, Meg Pirrung, Lee Ann McCue
Summary: FQC is software that facilitates quality control of FASTQ files by carrying out a QC protocol using FastQC, parsing results, and aggregating quality metrics into an interactive dashboard designed to richly summarize individual sequencing runs. The dashboard groups samples in dropdowns for navigation among the data sets, utilizes human-readable configuration files to manipulate the pages and tabs, and is extensible with CSV data. Availability and Implementation: FQC is implemented in Python 3 and Javascript, and is maintained under an MIT license...
June 9, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28604628/privacy-preserving-electrocardiogram-monitoring-for-intelligent-arrhythmia-detection
#11
Junggab Son, Juyoung Park, Heekuck Oh, Md Zakirul Alam Bhuiyan, Junbeom Hur, Kyungtae Kang
Long-term electrocardiogram (ECG) monitoring, as a representative application of cyber-physical systems, facilitates the early detection of arrhythmia. A considerable number of previous studies has explored monitoring techniques and the automated analysis of sensing data. However, ensuring patient privacy or confidentiality has not been a primary concern in ECG monitoring. First, we propose an intelligent heart monitoring system, which involves a patient-worn ECG sensor (e.g., a smartphone) and a remote monitoring station, as well as a decision support server that interconnects these components...
June 12, 2017: Sensors
https://www.readbyqxmd.com/read/28601028/qrs-complex-detection-in-ecg-signals-using-locally-adaptive-weighted-total-variation-denoising
#12
Tanushree Sharma, Kamalesh Kumar Sharma
The QRS complex is the most prominent feature in the electrocardiogram (ECG), therefore, its detection is required for delineation of other waves and segments in the ECG and derivation of additional clinically useful information. QRS detection is complicated by factors like varying QRS morphologies, noise, artefacts and interference from tall and pointed P- and T-waves. In this paper, we propose a novel technique for QRS detection by preprocessing the ECG using weighted total variation (WTV) denoising. A local estimate of noise in the signal block under consideration is used to determine the regularization parameter in WTV minimization, which determines the amount of smoothing applied...
June 7, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28599197/tomato-lycopersicon-esculentum-or-lycopene-supplementation-attenuates-ventricular-remodeling-after-myocardial-infarction-through-different-mechanistic-pathways
#13
Bruna L B Pereira, Patrícia P Reis, Fábio E Severino, Tainara F Felix, Mariana G Braz, Flávia R Nogueira, Renata A C Silva, Ana C Cardoso, Maria A M Lourenço, Amanda M Figueiredo, Fernanda Chiuso-Minicucci, Paula S Azevedo, Bertha F Polegato, Katashi Okoshi, Ana A H Fernandes, Sergio A R Paiva, Leonardo A M Zornoff, Marcos F Minicucci
The objective of this study was to evaluate the influence of tomato or lycopene supplementation on cardiac remodeling after myocardial infarction (MI). Male Wistar rats were assigned to four groups: the sham group (animals that underwent simulated surgery) that received a standard chow (S; n=18), the infarcted group that received a standard chow (MI; n=13), the infarcted group supplemented with lycopene (1 mg of lycopene/kg body weight/day) (MIL; n=16) and the infarcted group supplemented with tomato (MIT; n=16)...
June 1, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28591983/-clinical-and-pathologic-analysis-of-414-cases-of-renal-angiomyolipomain-in-a-single-institution
#14
H L Bao, X Chen, Y X An, H B Sun, H Y Wang, A T Guo
Objective: To study the different clinicopathological characteristics between classic and epithelioid renal angiomyolipoma, and the relationships between clinicopathological characteristics and biological behaviors as basis for clinical treatment. Methods: The clinicopathological and follow-up data for the patients diagnosed with renal angiomyolipoma between 2004 and 2011 were retrospectively reviewed and analyzed. Results: There were 414 cases of renal angiomyolipoma diagnosed over 8 years ago, accounting for 8...
June 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28591769/functional-characterisation-of-xenopus-thyroid-hormone-transporters-mct8-and-oatp1c1
#15
Bilal B Mughal, Michelle Leemans, Elaine C L de Souza, Sébastien le Mevel, Petra Spirhanzlova, Theo Visser, Jean-Baptiste Fini, Barbara A Demeneix
Xenopus is an excellent model for studying thyroid hormone signalling as it undergoes thyroid hormone-dependent metamorphosis. Despite the fact that receptors and deiodinases have been described in Xenopus, membrane transporters for these hormones are yet to be characterised. We cloned Xenopus monocarboxylate transporter 8 (mct8) and organic anion transporting polypeptide 1C1 (oatpc1c1), focusing on these two transporters given their importance for vertebrate brain development. Protein alignment and bootstrap analysis showed that Xenopus mct8 and oatp1c1 are closer to their mammalian orthologues than their teleost counterparts...
June 7, 2017: Endocrinology
https://www.readbyqxmd.com/read/28591452/professor-hiroaki-ueki-in-memoriam-ein-japaner-mit-herz-f%C3%A3-r-deutschland
#16
Gerd Plewig
No abstract text is available yet for this article.
June 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28591445/retrospektive-expositionsabsch%C3%A3-tzung-der-nat%C3%A3-rlichen-uv-strahlendosis-erfahrungen-mit-dem-online-uv-anamnese-instrument-im-feldversuch
#17
Wobbeke Weistenhöfer, Julia Hiller, Hans Drexler, Johannes Kiesel
No abstract text is available yet for this article.
June 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28588097/high-intensity-interval-training-and-calorie-restriction-promote-remodeling-of-glucose-and-lipid-metabolism-in-diet-induced-obesity
#18
Rachel A H Davis, Jacob E Halbrooks, Emily Watkins, Gordon Fisher, Gary R Hunter, Tim R Nagy, Eric P Plaisance
Calorie restriction (CR) decreases adiposity, but the magnitude and defense of weight loss is less than predicted due to reductions in total daily energy expenditure (TEE). The purpose of the current investigation was to determine if high-intensity interval training (HIIT) would increase markers of sympathetic activation in white adipose tissue (WAT) and rescue CR-mediated reductions in EE to a greater extent than moderate-intensity aerobic exercise training (MIT). Thirty-two 5-wk old male C57BL/6J mice were placed on ad libitum HFD for 11 weeks followed by randomization to one of four groups (n = 8 per group) for an additional 15 weeks: 1) CON (remain on HFD); 2) CR (25% lower energy intake); 3) CR+HIIT (25% energy deficit created by 12...
June 6, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28586483/isolated-mitochondria-transfer-improves-neuronal-differentiation-of-schizophrenia-derived-induced-pluripotent-stem-cells-and-rescues-deficits-in-a-rat-model-of-the-disorder
#19
Odile Robicsek, Hila M Ene, Rachel Karry, Ofer Ytzhaki, Eyal Asor, Donna McPhie, Bruce M Cohen, Rotem Ben-Yehuda, Ina Weiner, Dorit Ben-Shachar
Dysfunction of mitochondria, key players in various essential cell processes, has been repeatedly reported in schizophrenia (SZ). Recently, several studies have reported functional recovery and cellular viability following mitochondrial transplantation, mostly in ischemia experimental models. Here, we aimed to demonstrate beneficial effects of isolated active normal mitochondria (IAN-MIT) transfer in vitro and in vivo, using SZ-derived induced pluripotent stem cells (iPSCs) differentiating into glutamatergic neuron, as well as a rodent model of SZ...
June 6, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28582906/paroxysmal-atrial-fibrillation-recognition-based-on-multi-scale-r%C3%A3-nyi-entropy-of-ecg
#20
Yi Xin, Yizhang Zhao, Yuanhui Mu, Qin Li, Caicheng Shi
BACKGROUND: Atrial fibrillation (AF) is a common type of arrhythmia disease, which has a high morbidity and can lead to some serious complications. The ability to detect and in turn prevent AF is extremely significant to the patient and clinician. OBJECTIVE: Using ECG to detect AF and develop a robust and effective algorithm is the primary objective of this study. METHODS: Some studies show that after AF occurs, the regulatory mechanism of vagus nerve and sympathetic nerve will change...
May 19, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
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