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Shweta Jain, M K Ahirwal, Anil Kumar, V Bajaj, G K Singh
Electrocardiogram (ECG) is one of the most important physiological signals of human body, which contains important clinical information about the heart. Monitoring of ECG signal is done through QRS detection. In this paper, an improved QRS detection algorithm, based on adaptive filtering principle, has been designed. Enumeration of the effectiveness of various LMS variants used in adaptive filtering based QRS detection algorithm has been done through fidelity parameters like sensitivity and positive predictivity...
October 10, 2016: ISA Transactions
Bryan S Der, Emerson Glassey, Bryan A Bartley, Casper Enghuus, Daniel B Goodman, D Benjamin Gordon, Christopher A Voigt, Thomas E Gorochowski
DNAplotlib ( is a computational toolkit for the programmable visualization of highly customizable, standards-compliant genetic designs. Functions are provided to aid with both visualization tasks and to extract and overlay associated experimental data. High-quality output is produced in the form of vector-based PDFs, rasterized images, and animated movies. All aspects of the rendering process can be easily customized or extended by the user to cover new forms of genetic part or regulation...
October 17, 2016: ACS Synthetic Biology
Ekaterina A Khramtsova, Barbara E Stranger
: Over the last decade, genome-wide association studies (GWAS) have generated vast amounts of analysis results, requiring development of novel tools for data visualization. Quantile-quantile (QQ) plots and Manhattan plots are classical tools which have been utilized to visually summarize GWAS results and identify genetic variants significantly associated with traits of interest. However, static visualizations are limiting in the information that can be shown. Here we present ASSOCPLOTS: , a python package for viewing and exploring GWAS results not only using classic static Manhattan and QQ plots, but also through a dynamic extension which allows to interactively visualize the relationships between GWAS results from multiple cohorts or studies...
October 14, 2016: Bioinformatics
Serge Ayissi, Krisztián Palotás, Hanna Qin, Lijuan Yang, Paul A Charpentier
Rutile-monoclinic phase transitions of vanadium oxide (VO2) nanocrystals adsorbed on graphene-based substrates are of current scientific interest, although their adsorption and growth mechanisms have not been investigated theoretically. In this study, we use density functional theory (DFT) calculations for determining the binding energies and predicting the corresponding directions of growth of VO2 nanostructures (rutile and M1-monoclinic) interacting with both pure graphene and functionalized graphene nanoribbons...
October 12, 2016: Physical Chemistry Chemical Physics: PCCP
Hyunwoo Jin, Keundong Lee, Seung-Hyub Baek, Jin-Sang Kim, Byung-Ki Cheong, Bae Ho Park, Sungwon Yoon, B J Suh, Changyoung Kim, S S A Seo, Suyoun Lee
Interaction between electrons has long been a focused topic in condensed-matter physics since it has led to the discoveries of astonishing phenomena, for example, high-Tc superconductivity and colossal magnetoresistance (CMR) in strongly-correlated materials. In the study of strongly-correlated perovskite oxides, Nb-doped SrTiO3 (Nb:SrTiO3) has been a workhorse not only as a conducting substrate, but also as a host possessing high carrier mobility. In this work, we report the observations of large linear magnetoresistance (LMR) and the metal-to-insulator transition (MIT) induced by magnetic field in heavily-doped Nb:STO (SrNb0...
October 5, 2016: Scientific Reports
Ken-Ichi Tabei, Masayuki Satoh, Chizuru Nakano, Ai Ito, Yasuo Shimoji, Hirotaka Kida, Hajime Sakuma, Hidekazu Tomimoto
Melodic intonation therapy (MIT) is a treatment program for the rehabilitation of aphasic patients with speech production disorders. We report a case of severe chronic non-fluent aphasia unresponsive to several years of conventional therapy that showed a marked improvement following intensive 9-day training on the Japanese version of MIT (MIT-J). The purpose of this study was to verify the efficacy of MIT-J by functional assessment and examine associated changes in neural processing by functional magnetic resonance imaging...
2016: Frontiers in Neurology
Ang Li, Qian-Yuan Wu, Gui-Peng Tian, Hong-Ying Hu
Methylisothiazolone (MIT) is a common biocide that is widely used in water-desalination reverse-osmosis processes. The transformation of MIT during water treatment processes is poorly understood. The kinetics and mechanisms involved in the degradation of MIT during ozonation were investigated in this study. Ozonation was found to be a useful way of degrading MIT in water, and the degradation rate constant was 0.11 (±0.1) × 10(3) L/(mol·s). The degradation rate constant did not change when the pH was increased from 3 to 9...
December 1, 2016: Journal of Environmental Management
Sandeep Raj, Kailash Chandra Ray, Om Shankar
BACKGROUND AND OBJECTIVE: The increase in the number of deaths due to cardiovascular diseases (CVDs) has gained significant attention from the study of electrocardiogram (ECG) signals. These ECG signals are studied by the experienced cardiologist for accurate and proper diagnosis, but it becomes difficult and time-consuming for long-term recordings. Various signal processing techniques are studied to analyze the ECG signal, but they bear limitations due to the non-stationary behavior of ECG signals...
November 2016: Computer Methods and Programs in Biomedicine
Xiaoying Tian, Yongshuai Li, Huan Zhou, Xiang Li, Lisha Chen, Xuming Zhang
Electrocardiogram (ECG) signals contain a great deal of essential information which can be utilized by physicians for the diagnosis of heart diseases. Unfortunately, ECG signals are inevitably corrupted by noise which will severely affect the accuracy of cardiovascular disease diagnosis. Existing ECG signal denoising methods based on wavelet shrinkage, empirical mode decomposition and nonlocal means (NLM) cannot provide sufficient noise reduction or well-detailed preservation, especially with high noise corruption...
2016: Sensors
Raymond P Kesner
The structure and utilization of memory is central to one's knowledge of the past, interpretation of the present, and prediction of the future. Therefore, the understanding of the structural and process components of memory systems at the psychological and neurobiological level is of paramount importance. There have been a number of attempts to divide learning and memory into multiple memory systems. Schacter and Tulving, Memory systems 1994. MIT Press, Cambridge (1994) have suggested that one needs to define memory systems in terms of the kind of information to be represented, the processes associated with the operation of each system, and the neurobiological substrates, including neural structures and mechanisms, that subserve each system...
September 28, 2016: Current Topics in Behavioral Neurosciences
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No abstract text is available yet for this article.
September 2016: VASA. Zeitschrift Für Gefässkrankheiten
Matthew C Swain, Jacqueline M Cole
The emergence of "big data" initiatives has led to the need for tools that can automatically extract valuable chemical information from large volumes of unstructured data, such as the scientific literature. Since chemical information can be present in figures, tables, and textual paragraphs, successful information extraction often depends on the ability to interpret all of these domains simultaneously. We present a complete toolkit for the automated extraction of chemical entities and their associated properties, measurements, and relationships from scientific documents that can be used to populate structured chemical databases...
October 6, 2016: Journal of Chemical Information and Modeling
Fei Liu, Zi-Fa Li, Zhen-Yong Wang, Lin Wang
Ca(2+) signaling plays a vital role in regulating apoptosis and autophagy. We previously proved that cytosolic Ca(2+) overload is involved in cadmium (Cd)-induced apoptosis in rat proximal tubular (rPT) cells, but the source of elevated cytosolic Ca(2+) concentration ([Ca(2+)]c) and the effect of potential subcellular Ca(2+) redistribution on apoptosis and autophagy remain to be elucidated. Firstly, data showed that Cd-induced elevation of [Ca(2+)]c was primarily generated intracellularly. Moreover, elevations of [Ca(2+)]c and mitochondrial Ca(2+) concentration ([Ca(2+)]mit) with depletion of endoplasmic reticulum (ER) Ca(2+) levels ([Ca(2+)]ER) were revealed in Cd-treated rPT cells, but this subcellular Ca(2+) redistribution was significantly suppressed by 2-Aminoethoxydiphenyl borate (2-APB)...
September 14, 2016: Journal of Inorganic Biochemistry
Matthew Norris, Chun Kit Kwok, Jitender Cheema, Matthew Hartley, Richard J Morris, Sharon Aviran, Yiliang Ding
: Most RNA molecules form internal base pairs, leading to a folded secondary structure. Some of these structures have been demonstrated to be functionally significant. High-throughput RNA structure chemical probing methods generate millions of sequencing reads to provide structural constraints for RNA secondary structure prediction. At present, processed data from these experiments are difficult to access without computational expertise. Here we present FoldAtlas, a web interface for accessing raw and processed structural data across thousands of transcripts...
September 22, 2016: Bioinformatics
Y-R Jo, M-W Kim, B-J Kim
Nano-scale VO2 wires with controlled parameters such as electron-doping have attracted intense interest due to their capability of suppressing the temperature of the metal-insulator transition (MIT). However, because their diameters are smaller than the spatial resolutions of the conventional measuring equipment, the ability to perform a thorough examination of the wires has been hindered. Here, we report the fabrication of a transmission electron microscopy (TEM) grid with an optimum design of Si3N4 windows on which the photolithography for individual electron-doped VO2 nanowire devices can be safely accomplished, allowing the cross-examination of the structural and electrical properties...
September 23, 2016: Nanotechnology
M Tie, A-A Dhirani
Strong electron-electron interactions experienced by electrons as they delocalize are widely believed to play a key role in a range of remarkable phenomena such as high Tc superconductivity, colossal magnetoresistance, and others. Strongly correlated electrons are often described by the Hubbard model, which is the simplest description of a correlated system and captures important gross features of phase diagrams of strongly correlated materials. However, open challenges in this field include experimentally mapping correlated electron phenomena beyond those captured by the Hubbard model, and extending the model accordingly...
September 14, 2016: Journal of Chemical Physics
Yohei Ohashi, Nicolas Soler, Miguel García Ortegón, Lufei Zhang, Marie L Kirsten, Olga Perisic, Glenn R Masson, John E Burke, Arjen J Jakobi, Apostolos A Apostolakis, Christopher M Johnson, Maki Ohashi, Nicholas T Ktistakis, Carsten Sachse, Roger L Williams
The phosphatidylinositol 3-kinase Vps34 is part of several protein complexes. The structural organization of heterotetrameric complexes is starting to emerge, but little is known about organization of additional accessory subunits that interact with these assemblies. Combining hydrogen-deuterium exchange mass spectrometry (HDX-MS), X-ray crystallography and electron microscopy (EM), we have characterized Atg38 and its human ortholog NRBF2, accessory components of complex I consisting of Vps15-Vps34-Vps30/Atg6-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34-BECN1/Beclin 1-ATG14 (human)...
September 14, 2016: Autophagy
Ning Song, Ming Zhao, Yuji Wang, Xi Hu, Jianhui Wu, Xueyun Jiang, Shan Li, Chunying Cui, Shiqi Peng
In spite of the usual combination form of methotrexate (MTX)/mitoxantrone (MIT) and various complex combination regimens of MTX/MIT with other anticancer drugs, the survival period, cure rate, and systemic toxicity still need to be improved. For this purpose, a nanostructured amino group-modified mesoporous silica nanoparticles (MSNN)-MTX/MIT was designed. In the preparation, the surface of mesoporous silica nanoparticles (MSNs) was modified with amino groups to form MSNN. The covalent modification of the amino groups on the surface of MSNN with MTX resulted in MSNN-MTX...
2016: Drug Design, Development and Therapy
S R Stewart, P W Barone, A Bellisario, C L Cooney, P A Sharp, A J Sinskey, S Natesan, S L Springs
Despite the rapid pace of biomedical innovation, R&D productivity in the pharmaceutical industry has not improved broadly. Increasingly, firms need to leverage new approaches to product development and commercial execution, while maintaining adaptability to rapid changes in the marketplace and in biomedical science. Firms are also seeking ways to capture some of the talent, infrastructure, and innovation that depends on federal R&D investment. As a result, a major transition to external innovation is taking place across the industry...
September 12, 2016: Clinical Pharmacology and Therapeutics
Matei David, L J Dursi, Delia Yao, Paul C Boutros, Jared T Simpson
MOTIVATION: The highly portable Oxford Nanopore MinION sequencer has enabled new applications of genome sequencing directly in the field. However, the MinION currently relies on a cloud computing platform, Metrichor (, for translating locally generated sequencing data into basecalls. RESULTS: To allow offline and private analysis of MinION data, we created Nanocall. Nanocall is the first freely-available, open-source basecaller for Oxford Nanopore sequencing data and does not require an internet connection...
September 10, 2016: Bioinformatics
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