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Rejection of Care

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https://www.readbyqxmd.com/read/28733800/steroid-mediated-decrease-in-blood-mesenchymal-stem-cells-in-liver-transplant-could-impact-long-term-recovery
#1
Nykia D Walker, Yasmine Mourad, Katherine Liu, Michael Buxhoeveden, Catherine Schoenberg, Jean D Eloy, Dorian J Wilson, Lloyd G Brown, Andrei Botea, Faraz Chaudhry, Steven J Greco, Nicholas M Ponzio, Nikolaos Pyrsopoulos, Baburao Koneru, Yuriy Gubenko, Pranela Rameshwar
Orthotopic liver transplant (OLT) remains the standard of care for end stage liver disease. To circumvent allo-rejection, OLT subjects receive gluococorticoids (GC). We investigated the effects of GC on endogenous mesenchymal stem (stromal) cells (MSCs) in OLT. This question is relevant because MSCs have regenerative potential and immune suppressor function. Phenotypic analyses of blood samples from 12 OLT recipients, at pre-anhepatic, anhepatic and post-transplant (2 h, Days 1 and 5) indicated a significant decrease in MSCs after GC injection...
July 21, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28733461/should-heart-failure-be-regarded-as-a-terminal-illness-requiring-palliative-care-a-study-of-heart-failure-patients-carers-and-clinicians-understanding-of-heart-failure-prognosis-and-its-management
#2
Rachel Stocker, Helen Close, Helen Hancock, A Pali S Hungin
OBJECTIVES: Communication and planning for heart failure (HF) care near the end of life is known to be complex. Little is known about how the patient experience of palliative assessment and communication needs change over time, and how this might inform management. Our aim was to explore experiences of giving or receiving a prognosis and advanced palliative care planning (ACP) for those with HF. METHODS: We carried out a longitudinal grounded theory study, employing in-depth interviews with 14 clinicians (primary and secondary care) and observations of clinic and home appointments, followed by a series of interviews with 13 patients with HF and 9 carers...
July 21, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28732465/genome-wide-signals-of-positive-selection-in-strongylocentrotid-sea-urchins
#3
Kord M Kober, Grant H Pogson
BACKGROUND: Comparative genomics studies investigating the signals of positive selection among groups of closely related species are still rare and limited in taxonomic breadth. Such studies show great promise in advancing our knowledge about the proportion and the identity of genes experiencing diversifying selection. However, methodological challenges have led to high levels of false positives in past studies. Here, we use the well-annotated genome of the purple sea urchin, Strongylocentrotus purpuratus, as a reference to investigate the signals of positive selection at 6520 single-copy orthologs from nine sea urchin species belonging to the family Strongylocentrotidae paying careful attention to minimizing false positives...
July 21, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28731824/evolutionary-scenarios-and-primate-natural-history
#4
Harry W Greene
Scenarios summarize evolutionary patterns and processes by interpreting organismal traits and their natural history correlates in a phylogenetic context. They are constructed by (1) describing phenotypes (including physiology and behavior), ideally with attention to formative roles of development, experience, and culture; (2) inferring homologies, homoplasies, ancestral character states, and their transformations with phylogenetic analyses; and (3) integrating those components with ecological and other ancillary data...
August 2017: American Naturalist
https://www.readbyqxmd.com/read/28725393/water-mold-infection-but-not-paternity-induces-selective-filial-cannibalism-in-a-goby
#5
Martin Vallon, Nils Anthes, Katja U Heubel
Many animals heavily invest in parental care but still reject at least some of their offspring. Although seemingly paradoxical, selection can favor parents to neglect offspring of particularly low reproductive value, for example, because of small survival chances. We here assess whether filial cannibalism (FC), where parents routinely eat some of their own young, is selective in response to individual offspring reproductive value. We performed two independent laboratory experiments in the common goby (Pomatoschistus microps) to test whether caring fathers preferentially cannibalize eggs of a given infection history and paternity...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28722167/assisted-autogenic-drainage-in-infants-and-young-children-hospitalized-with-uncomplicated-pneumonia-a-pilot-study
#6
Lieselotte Corten, Jennifer Jelsma, Anri Human, Sameer Rahim, Brenda M Morrow
BACKGROUND AND PURPOSE: Pneumonia is the most important respiratory problem in low-to-middle income countries. Airway clearance therapy continues to be used in children with pneumonia and secretion retention; however, there is lack of evidence to support or reject this treatment. This study aimed to investigate the feasibility of a randomized controlled trial (RCT) on the efficacy and safety of assisted autogenic drainage (AAD) compared to standard nursing care in children hospitalized with uncomplicated pneumonia...
July 19, 2017: Physiotherapy Research International: the Journal for Researchers and Clinicians in Physical Therapy
https://www.readbyqxmd.com/read/28719723/de-novo-hhv-8-tumors-induced-by-rituximab-in-autoimmune-or-inflammatory-systemic-diseases
#7
Amandine Perier, Léa Savey, Anne-Geneviève Marcelin, Philippe Serve, David Saadoun, Stéphane Barete
OBJECTIVES: HHV-8, also known as Kaposi's sarcoma (KS) associated herpesvirus is involved in KS and other tumors comprising multicentric Castleman disease (MCD) and primary effusion lymphoma (PEL). Rituximab is currently used for treatment of several autoimmune or inflammatory diseases and humoral organ rejection. De novo HHV-8 induced tumors by rituximab used for autoimmune or inflammatory diseases or humoral organ rejection have not been reported. METHODS: In this retrospective study, we report clinical, virological and pathology of five HIV-negative male patients with HHV-8-induced tumors following rituximab therapy...
July 18, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28715439/knowledge-attitude-and-perceived-stigma-towards-tuberculosis-among-pastoralists-do-they-differ-from-sedentary-communities-a-comparative-cross-sectional-study
#8
Bezawit Temesgen Sima, Tefera Belachew, Fekadu Abebe
BACKGROUND: Ethiopia is ninth among the world high tuberculosis (TB) burden countries, pastoralists being the most affected population. However, there is no published report whether the behavior related to TB are different between pastoralist and the sedentary communities. Therefore, the main aim of this study is to assess the pastoralist community knowledge, attitude and perceived stigma towards tuberculosis and their health care seeking behavior in comparison to the neighboring sedentary communities and this may help to plan TB control interventions specifically for the pastoralist communities...
2017: PloS One
https://www.readbyqxmd.com/read/28714558/everolimus-and-reduced-calcineurin-inhibitor-therapy-in-pediatric-liver-transplant-recipients-results-from-a-multicenter-prospective-study
#9
Rainer Ganschow, Bo-Goran Ericzon, Anil Dhawan, Khalid Sharif, El-Djouher Martzloff, Barbara Rauer, Jennifer Ng, Patricia Lopez
In a 24-month, multicenter, single-arm, prospective study, 56 pediatric liver transplant patients with or without basiliximab induction were converted at 1-6 months post-transplant from standard calcineurin inhibitor (CN) therapy (± mycophenolic acid), to everolimus with reduced exposure to CNI (tacrolimus n=50, cyclosporine n=6). Steroid therapy was optional. Recruitment was stopped prematurely due to high rates of PTLD, treatment-related serious infections leading to hospitalization and premature study drug discontinuation...
July 17, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28711221/the-evolution-of-lung-transplantation-for-cystic-fibrosis-a-2017-update
#10
REVIEW
Gregory Snell, Anna Reed, Marc Stern, Denis Hadjiliadis
Lung transplantation (LTx) is an established therapy for patients with end-stage cystic fibrosis (CF). Indeed, CF is the commonest indication for those aged<50years of age needing LTx. CF LTx is associated with a 45% 10year survival - according to the world's largest registry. It is important all otherwise suitable CF patients with severe lung disease have a timely referral for discussion and consideration of the possibility of LTx. LTx discussions must carefully consider colonisation or infection with Burkholderia cenocepacia, Mycobacterium abscessus and Scediosporium - as good LTx outcomes cannot be guaranteed...
July 12, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28707637/implementation-and-sex-specific-analysis-of-students-attitudes-toward-a-longitudinal-gender-specific-medical-curriculum-a-pilot-study
#11
Anja Böckers, Claudia Grab, Christiane Waller, Ulrike Schulze, Susanne Gerhardt-Szep, Benjamin Mayer, Tobias Maria Böckers, Wolfgang Öchsner
BACKGROUND: Gender medicine has gained importance over the past 20 years. Nevertheless, the scientific findings concerning gender- and sex-specific patient care have not been sufficiently integrated into the education of physicians. It was therefore our aim, against initial resistance in our school, to integrate clinically relevant aspects of gender medicine into the existing medical curriculum. This paper describes the implementation process of a lecture-based interdisciplinary, longitudinal, basic gender curriculum and evaluates students' attitudes in relation to sex and semester level...
January 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/28702185/potential-cost-savings-by-minimisation-of-blood-sample-delays-on-care-decision-making-in-urgent-care-services
#12
David M S Bodansky, Sophie E Lumley, Rudrajoy Chakraborty, Dhanasekaran Mani, James Hodson, Mike T Hallissey, Olga N Tucker
BACKGROUND: Timely availability of blood sample results for interpretation affects planning and delivery of patient care from initial assessment in Accident and Emergency (A&E) departments. MATERIALS AND METHODS: Rates of, and reasons for, rejected blood samples submitted from all clinical areas over one month were evaluated. Haemoglobin (Hb) represented haematology and potassium (K(+)), biochemistry. A prospective observational study evaluated the methodology of sample collection and impact on utility...
August 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28699897/posttransplant-lymphoproliferative-disorders-in-kidney-transplant-recipients-a-retrospective-cohort-analysis-over-two-decades-in-hong-kong
#13
Chi Yuen Cheung, Maggie Kam Man Ma, Ka Foon Chau, Wai Leung Chak, Sydney Chi Wai Tang
OBJECTIVE: To characterize the posttransplant lymphoproliferative disorders (PTLD) including the Epstein-Barr virus (EBV) status, histological subgroups, site of occurrence and the clinical outcome in the Chinese kidney transplant recipients. METHODS: A retrospective cohort study of 1, 227 adult kidney transplant recipients who were followed up in two transplant centers in Hong Kong over two decades. RESULTS: 23 (1.9%) patients developed PTLD...
June 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28697715/conversion-from-once-daily-prolonged-release-tacrolimus-to-once-daily-extended-release-tacrolimus-in-stable-liver-transplant-recipients
#14
Mario Altieri, Guillaume Delaval, Elisabeth Kimmoun, Manon Allaire, Ephrem Salamé, Jérôme Dumortier
OBJECTIVES: After organ transplant, strategies to simplify the therapeutic regimen may improve adherence and prevent rejection and/or graft loss. The aim of the present study was to evaluate the safety of conversion from once-daily prolonged-release tacrolimus (Advagraf; Astellas Pharma Europe Limited, Middlesex, UK) to once-daily extended-release tacrolimus (Envarsus; Chiesi SAS, Nanterre, France) in stable adult liver transplant recipients. MATERIALS AND METHODS: This observational study inclu-ded 44 liver transplant patients (median age of 59 y; 63...
July 11, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28693870/the-impact-of-parental-reaction-to-sexual-orientation-on-depressive-symptoms-and-sexual-risk-behavior-among-hispanic-men-who-have-sex-with-men
#15
Victoria B Mitrani, Joseph P De Santis, Brian E McCabe, Diego A Deleon, Karina A Gattamorta, Natalie M Leblanc
PURPOSE: This study examined the relationship of parent reaction to sexual orientation with depressive symptoms and safer sex among Hispanic adult men who have sex with men (MSM). We also examined men's acculturation to the U.S. (Americanism) in relation with these variables. METHOD: Cross-sectional data collected from July 2011 to December 2012, from 125 MSM with a mean age of 43.02years. Instruments included the Perceived Parent Reaction Scale, the Centers for Epidemiological Studies Depression Scale, the Safer Sex Behavior Questionnaire and the Bidimensional Acculturation Scale...
August 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28688168/-hidden-identities-perceptions-of-sexual-identity-in-beijing
#16
Toby Miles-Johnson, Yurong Wang
This article draws upon responses given by volunteers who work in the Beijing LGBT Centre regarding perceptions of sexual identity, and how Chinese culture affects hidden or open sexual identities of Chinese lesbian and gay people in this region. The insights gained from those working carefully to create social change offers an important and original contribution to the field of gay and lesbian studies in China. The findings indicate the volunteers at the Beijing LGBT Centre are frustrated by the lack of acceptance of non-heterosexual relationships among Chinese culture and society, and by the disregard of lesbian gay and bisexual (LGB) people by the Chinese government...
July 8, 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/28679411/child-and-parent-predictors-of-picky-eating-from-preschool-to-school-age
#17
Silje Steinsbekk, Arielle Bonneville-Roussy, Alison Fildes, Clare H Llewellyn, Lars Wichstrøm
BACKGROUND: Picky eating is prevalent in childhood. Because pickiness concerns parents and is associated with nutrient deficiency and psychological problems, the antecedents of pickiness need to be identified. We propose an etiological model of picky eating involving child temperament, sensory sensitivity and parent-child interaction. METHODS: Two cohorts of 4-year olds (born 2003 or 2004) in Trondheim, Norway were invited to participate (97.2% attendance; 82.0% consent rate, n = 2475) and a screen-stratified subsample of 1250 children was recruited...
July 6, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28678900/clinical-care-of-nursing-reasoned-in-parse-contribution-in-the-transcendence-process-of-cardiac-transplantation
#18
Lia Bezerra Furtado Barros, Lúcia de Fátima da Silva, Maria Vilani Cavalcante Guedes, Vera Lúcia Mendes de Paula Pessoa
Objetivo: To identify how the clinical and educational nursing care based on the Theory of Human Becoming can contribute to the transcendence process of heart transplant patients in pursuit of good living. Method: Research-intervention developed with four heart transplant patients linked to a reference transplant hospital in Ceara. Data was collected through interviews in 2014 and analyzed using Parse's theoretical framework and pertinent literature. Resultados: Transplant patients revealed they gave living in such condition an ambiguous meaning, showing satisfaction and dissatisfaction...
June 29, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28678898/strategies-used-by-nursing-staff-in-situations-of-workplace-violence-in-a-haemodialysis-unit
#19
Onélia da Costa Pedro Cordenuzzi, Suzinara Beatriz Soares de Lima, Francine Cassol Prestes, Carmem Lúcia Colomé Beck, Rosângela Marion da Silva, Daiane Dal Pai
Objective: To identify strategies that nursing staff use at a haemodialysis unit in situations of violence by patients during care. Method: Qualitative descriptive and exploratory research with focus groups and the participation of eight workers of the nursing staff of a private haemodialysis unit in southern Brazil. The data were subjected to thematic content analysis. Results: The adopted strategies are described in the following categories: Tolerating violence due to the patient's health condition; Working around conflicting situations and giving in to patient's requests; Adopting a position of rejection to violence; and Staying away from the aggressor patient...
June 29, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28674741/new-tumour-entities-in-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-odontogenic-and-maxillofacial-bone-tumours
#20
REVIEW
Paul M Speight, Takashi Takata
The latest (4th) edition of the World Health Organization Classification of Head and Neck tumours has recently been published with a number of significant changes across all tumour sites. In particular, there has been a major attempt to simplify classifications and to use defining criteria which can be used globally in all situations, avoiding wherever possible the use of complex molecular techniques which may not be affordable or widely available. This review summarises the changes in Chapter 8: Odontogenic and maxillofacial bone lesions...
July 3, 2017: Virchows Archiv: An International Journal of Pathology
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