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Rejection of Care

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https://www.readbyqxmd.com/read/29781954/range-and-consistency-of-outcomes-reported-in-randomized-trials-conducted-in-kidney-transplant-recipients-a-systematic-review
#1
Bénédicte Sautenet, Allison Tong, Jeremy R Chapman, Anthony N Warrens, David Rosenbloom, Germaine Wong, John Gill, Klemens Budde, Lionel Rostaing, Lorna Marson, Michelle A Josephson, Peter P Reese, Timothy L Pruett, Nicole Evangelidis, Jonathan C Craig
BACKGROUND: The potential for clinical trials to impact patient care may be limited if the outcomes reported vary by trial and lack direct relevance to patients. Despite the many trials conducted in kidney transplantation, premature death due to cardiovascular disease, infection and malignancy remains high. We aimed to assess the range and consistency of outcomes reported in trials in kidney transplantation. METHODS: We searched for randomized trials conducted in kidney transplantation...
May 16, 2018: Transplantation
https://www.readbyqxmd.com/read/29771697/influenza-vaccine-strategies-for-solid-organ-transplant-recipients
#2
Cédric Hirzel, Deepali Kumar
PURPOSE OF REVIEW: The aim of this study was to highlight recent evidence on important aspects of influenza vaccination in solid organ transplant recipients. RECENT FINDINGS: Influenza vaccine is the most evaluated vaccine in transplant recipients. The immunogenicity of the vaccine is suboptimal after transplantation. Newer formulations such as inactivated unadjuvanted high-dose influenza vaccine and the administration of a booster dose within the same season have shown to increase response rates...
May 15, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29766640/subclinical-inflammation-phenotypes-and-long-term-outcomes-after-pediatric-kidney-transplantation
#3
Michael E Seifert, Megan V Yanik, Daniel I Feig, Vera Hauptfeld-Dolejsek, Elizabeth C Mroczek-Musulman, David R Kelly, Frida Rosenblum, Roslyn B Mannon
The implementation of surveillance biopsies in pediatric kidney transplantation remains controversial. Surveillance biopsies detect subclinical injury prior to clinical dysfunction, which could allow for early interventions that prolong allograft survival. We conducted a single-center retrospective cohort study of 120 consecutive pediatric kidney recipients, of whom 103 had surveillance biopsies ≤ 6 months post-transplant. We tested the hypothesis that subclinical inflammation (borderline or T cell-mediated rejection without clinical dysfunction) is associated with a 5-year composite endpoint of acute rejection and allograft failure...
May 15, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29765577/perception-of-family-caregivers-about-barriers-of-leisure-in-care-of-individuals-with-chronic-psychiatric-disorders-a-qualitative-study
#4
Batool Mandani, Seyed Ali Hosseini, Mohammad Ali Hosseini, Ashraf Karbalaie Noori, Mohammad Reza Khodaie Ardakani
Background: Family caregivers of individuals with chronic psychiatric disorders play an important role in the management of the patient's conditions, which interferes with other activities of daily living, work, social and leisure activities. Objective: This study was conducted in an Iranian context to explore the perception of family caregivers about barriers of leisure in care of individuals with chronic psychiatric disorders. Methods: The current qualitative study was conducted on the basis of conventional content analysis...
March 2018: Electronic Physician
https://www.readbyqxmd.com/read/29757414/vaccination-coverage-in-systemic-lupus-erythematosus-a-cross-sectional-analysis-of-the-german-long-term-study-lula-cohort
#5
Gamal Chehab, Jutta G Richter, Ralph Brinks, Rebecca Fischer-Betz, Borgi Winkler-Rohlfing, Matthias Schneider
Objectives: Vaccinations are an important measure to prevent infections in immunocompromised patients. The knowledge of vaccination coverage and reasons for non-vaccination in patients with SLE is scarce. The aim of this study was to assess coverage rates of selected vaccinations in a representative sample of SLE patients and to identify predictors for non-vaccination. Methods: In 2013, information on selected vaccinations (coverage, application and reservations) and on demographics, clinical parameters and health beliefs was assessed by means of a self-reported questionnaire among a representative sample of SLE patients in Germany (LuLa cohort)...
May 10, 2018: Rheumatology
https://www.readbyqxmd.com/read/29752867/topical-application-of-culture-expanded-cd34-umbilical-cord-blood-cells-from-frozen-units-accelerates-healing-of-diabetic-skin-wounds-in-mice
#6
Jennifer Whiteley, Theresa Chow, Hibret Adissu, Armand Keating, Ian M Rogers
Chronic and nonhealing wounds are constant health issues facing patients with type 2 diabetes. As the incidence of type 2 diabetes mellitus (T2DM) increases, the incidence of chronic wounds and amputations will rise. T2DM is associated with peripheral arterial occlusive disease, which leads to the development of nonhealing skin ulcers after minor trauma. Patients develop severe pain limiting their mobility and ability to work and take care of themselves thus putting a significant burden on the family and society...
May 12, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29747793/reporting-quality-of-randomized-controlled-trials-of-periodontal-diseases-in-journal-abstracts-a-cross-sectional-survey-and-bibliometric-analysis
#7
Satish Kumar, Husain Mohammad, Hita Vora, Kian Kar
OBJECTIVE: Randomized controlled trials (RCTs) by proper design, conduct, analysis, and reporting provide reliable information in clinical care. Reporting of RCT abstracts is of equal importance as there is evidence that many clinicians will change their clinical decisions based on RCT abstracts. The reporting quality of RCT abstracts has been suboptimal. It is not clear whether the reporting quality is related to the journal metrics. The main objective of this study is to conduct a cross-sectional survey to evaluate the reporting quality of RCTs of periodontal diseases in journal abstracts and to perform a bibliometric analysis...
June 2018: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/29746538/use-of-the-emergency-department-by-refugees-under-the-interim-federal-health-program-a-health-records-review
#8
Francis Bakewell, Sarah Addleman, Garth Dickinson, Venkatesh Thiruganasambandamoorthy
INTRODUCTION: In June 2012, the federal government made cuts to the Interim Federal Health (IFH) Program that reduced or eliminated health insurance for refugee claimants in Canada. The purpose of this study was to examine the effect of the cuts on emergency department (ED) use among patients claiming IFH benefits. METHODS: We conducted a health records review at two tertiary care EDs in Ottawa. We reviewed all ED visits where an IFH claim was made at triage, for 18 months before and 18 months after the changes to the program on June 30, 2012 (2011-2013)...
2018: PloS One
https://www.readbyqxmd.com/read/29742115/detecting-the-contagion-effect-in-mass-killings-a-constructive-example-of-the-statistical-advantages-of-unbinned-likelihood-methods
#9
Sherry Towers, Anuj Mubayi, Carlos Castillo-Chavez
BACKGROUND: When attempting to statistically distinguish between a null and an alternative hypothesis, many researchers in the life and social sciences turn to binned statistical analysis methods, or methods that are simply based on the moments of a distribution (such as the mean, and variance). These methods have the advantage of simplicity of implementation, and simplicity of explanation. However, when null and alternative hypotheses manifest themselves in subtle differences in patterns in the data, binned analysis methods may be insensitive to these differences, and researchers may erroneously fail to reject the null hypothesis when in fact more sensitive statistical analysis methods might produce a different result when the null hypothesis is actually false...
2018: PloS One
https://www.readbyqxmd.com/read/29735214/effect-of-vasoactive-therapy-used-for-brain-dead-donors-on-graft-survival-after-kidney-transplantation
#10
D Birtan, M K Arslantas, G T Altun, P C Dincer, S Gecegormez, A Demirel, H O Ayanoglu
Serum catecholamine levels and peripheral vascular resistance decrease after brain death. Vasoactive drugs are used to control these hemodynamic changes and to improve perfusion of the organs. These drugs might have a role in rejection or loss of the graft organ. We aimed to investigate the effects of vasoactive drugs used in the cadaveric donor care on post-transplant renal graft functions. In this retrospective study, medical records of 135 cadaveric donors (270 kidneys) and recipients of these kidneys were evaluated...
May 4, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29731924/the-spectrum-of-histopathological-changes-in-the-renal-allograft-a-12-months-protocol-biopsy-study
#11
Galina Severova-Andreevska, Ladislava Grcevska, Gordana Petrushevska, Koco Cakalaroski, Aleksandar Sikole, Olivera Stojceva-Taneva, Ilina Danilovska, Ninoslav Ivanovski
INTRODUCTION: Renal transplantation became a routine and successful medical treatment for Chronic Kidney Disease in the last 30 years all over the world. Introduction of Luminex based Single Antigen Beads (SAB) and recent BANFF consensus of histopathological phenotypes of different forms of rejection enables more precise diagnosis and changes the therapeutic approach. The graft biopsies, protocol or cause, indicated, remain a golden diagnostic tool for clinical follow up of kidney transplant recipients (KTR)...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29731084/impact-of-pretransplant-infections-on-clinical-course-in-liver-transplant-recipients
#12
Y J Kim, J H Yoon, S I Kim, H J Choi, J Y Choi, S K Yoon, Y-K You, D-G Kim
BACKGROUND: Uncontrolled infections are known to be an absolute contraindication for liver transplantation; however, the posttransplant prognosis of recipients treated for pretransplant infection is unclear. The aim of this study was to analyze pretransplant infections among liver transplant recipients and to determine their impact on posttransplant clinical outcomes. METHODS: This study retrospectively analyzed 357 subjects who had undergone living-donor liver transplantation between January 2008 and May 2014...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29719371/p-t-committee-drug-prioritization-criteria-a-tool-developed-by-a-saudi-health-care-system
#13
Laila Carolina Abu Esba, Hind Almodaimegh, Ali Alhammad, Mazen Ferwana, Consuela Yousef, Sherine Ismail
Introduction: The workflow of a P&T committee can become overwhelming and may be affected by many internal and external factors. Organization, standardization, and an enhanced systematic approach for drug evaluations are necessary to ensure that all requested drugs receive an equal and unbiased evaluation and consideration for addition based on the institution's objectives, priorities, and budget. Our aim was to create a scoring tool that would assist in systematically prioritizing drugs being requested for formulary addition and to eliminate cumbersome evaluations for drugs that clearly do not offer any additional advantage...
May 2018: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29718562/solidarity-as-a-national-health-care-strategy
#14
Peter West-Oram
The Trump Administration's recent attempts to repeal the Affordable Care Act have reignited long-running debates surrounding the nature of justice in health care provision, the extent of our obligations to others, and the most effective ways of funding and delivering quality health care. In this article, I respond to arguments that individualist systems of health care provision deliver higher-quality health care and promote liberty more effectively than the cooperative, solidaristic approaches that characterize health care provision in most wealthy countries apart from the United States...
May 2, 2018: Bioethics
https://www.readbyqxmd.com/read/29703119/individuals-experiences-with-brief-admission-during-the-implementation-of-the-brief-admission-sk%C3%A3-ne-rct-a-qualitative-study
#15
Marjolein Helleman, Lars-Gunnar Lundh, Sophie I Liljedahl, Daiva Daukantaité, Sofie Westling
BACKGROUND: Brief admission (BA) is an adjunctive treatment option for individuals with self-harming behavior, having traits of borderline personality disorder (BPD). It is offered alongside outpatient psychotherapy for the purpose of strengthening autonomy, self-reflection and self-care and to increase the likelihood of being able to stay in therapy by avoiding lengthy inpatient hospitalizations. AIMS: To investigate participants' experiences with BA during the pilot phase of the Brief Admission Skåne Randomized Controlled Trial (BASRCT), in order to detect possible strengths and limitations of the intervention and gain knowledge to facilitate implementation of BA at other treatment centers...
April 27, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29694710/strategies-that-reduce-90-day-readmissions-and-inpatient-costs-after-liver-transplantation
#16
Joseph H Zeidan, David M Levi, Ruth Pierce, Mark W Russo
BACKGROUND: Liver transplantation is hospital-resource intensive and associated with high rates of readmission. We have previously shown a reduction in 30-day readmission rates by implementing a specifically designed protocol to increase access to outpatient care. AIM: To determine if strategies that reduce 30-day readmission after liver transplant were effective in also reducing 90-day readmission rates and costs. METHODS: A protocol was developed to reduce inpatient readmissions after liver transplant that expanded outpatient services and provided alternatives to readmission...
April 25, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29691950/adapting-evidence-based-clinical-practice-guidelines-at-university-teaching-hospitals-a-model-for-the-eastern-mediterranean-region
#17
Yasser S Amer, Hayfaa A Wahabi, Manal M Abou Elkheir, Ghada A Bawazeer, Shaikh M Iqbal, Maher A Titi, Aishah Ekhzaimy, Khalid A Alswat, Rasmieh A Alzeidan, Lubna A Al-Ansary
RATIONALE, AIMS, AND OBJECTIVES: Clinical practice guidelines (CPGs) are significant tools for evidence-based health care quality improvement. The CPG program at King Saud University was launched as a quality improvement program to fulfil the international accreditation standards. This program was a collaboration between the Research Chair for Evidence-Based Healthcare and Knowledge Translation and the Quality Management Department. This study aims to develop a fast-track method for adaptation of evidence-based CPGs and describe results of the program...
April 24, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29684190/can-online-social-support-be-detrimental-in-stigmatized-chronic-diseases-a-quadratic-model-of-the-effects-of-informational-and-emotional-support-on-self-care-behavior-of-hiv-patients
#18
Xunyi Wang, Srikanth Parameswaran, Darshan Mahendra Bagul, Rajiv Kishore
Objective: We studied the impact of online social support on patient self-care behavior in an online health community for human immunodeficiency virus (HIV) patients. We conceptualized emotional and informational support provided by community members into nuanced sub-dimensions. We explored how the direct and interaction effects of these sub-dimensions impact the self-care behavior of a support seeker. Methods: We used data from 330 255 posts in 30 050 threads from POZ, an online health community for HIV patients...
April 18, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29679826/improving-the-organic-and-biological-fouling-resistance-and-removal-of-pharmaceutical-and-personal-care-products-through-nanofiltration-by-using-in-situ-radical-graft-polymerization
#19
Yi-Li Lin, Chia-Cheng Tsai, Nai-Yun Zheng
In this study, an insitu radical graft polarization technique using monomers of 3-sulfopropyl methacrylate potassium salt (SPM) and 2-hydroxyethyl methacrylate (HEMA) was applied to a commercial nanofiltration membrane (NF90) to improve its removal of six commonly detected pharmaceutical and personal care products (PPCPs) and mitigate organic and biological fouling by humic acid (HA) and sodium alginate (SA). Compared with the virgin membrane, the modified NF90 membrane exhibited considerably improved fouling resistance and an increased reversible fouling percentage, especially for SA+HA composite fouling Moreover, the PPCP removal of the modified NF90 membrane was higher than that of the virgin membrane after SA and SA+HA fouling, respectively...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29676957/increasing-information-dissemination-in-cancer-communication-effects-of-using-palliative-supportive-or-hospice-care-terminology
#20
Jessica M Fishman, Patricia Greenberg, Margy Barbieri Bagga, David Casarett, Kathleen Propert
BACKGROUND: When attempting to share information about comfort-oriented care, many use "palliative," "supportive," and "hospice" care terminology interchangeably, but we lack evidence about the effects of using these different terms. OBJECTIVES: This study was designed to test whether the use of "palliative," "supportive," or "hospice" terminology can improve the dissemination of information among breast cancer patients-a large and growing oncology population...
April 20, 2018: Journal of Palliative Medicine
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