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https://www.readbyqxmd.com/read/28212320/a-mediterranean-diet-to-improve-cardiovascular-and-cognitive-health-protocol-for-a-randomised-controlled-intervention-study
#1
Alexandra T Wade, Courtney R Davis, Kathryn A Dyer, Jonathan M Hodgson, Richard J Woodman, Hannah A D Keage, Karen J Murphy
The Mediterranean diet has demonstrated efficacy for improving cardiovascular and cognitive health. However, a traditional Mediterranean diet delivers fewer serves of dairy and less dietary calcium than is currently recommended in Australia, which may limit long-term sustainability. The present study aims to evaluate whether a Mediterranean diet with adequate dairy and calcium can improve cardiovascular and cognitive function in an at-risk population, and thereby reduce risk of cardiovascular disease (CVD) and cognitive decline...
February 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28211024/comparative-effectiveness-research-of-disease-modifying-therapies-for-the-management-of-multiple-sclerosis-analysis-of-a-large-health-insurance-claims-database
#2
Aaron Boster, Jacqueline Nicholas, Ning Wu, Wei-Shi Yeh, Monica Fay, Michael Edwards, Ming-Yi Huang, Andrew Lee
INTRODUCTION: Limited data are available on the real-world effectiveness of newer oral disease-modifying therapies (DMTs) in multiple sclerosis. The purpose of this study was to retrospectively compare the real-world effectiveness of dimethyl fumarate (DMF), fingolimod, teriflunomide, and injectable DMTs in routine clinical practice based on US claims data. METHODS: Patients newly-initiating DMF, interferon beta (IFNβ), glatiramer acetate (GA), teriflunomide, or fingolimod in 2013 were identified in the Truven MarketScan Commercial Claims Databases (N = 6372)...
February 16, 2017: Neurology and Therapy
https://www.readbyqxmd.com/read/28207378/book-review-atlas-of-histology-of-the-juvenile-rat-atlas-of-histology-of-the-juvenile-rat-parker-george-a-picut-catherine-a-editors-academic-press-elsevier-cambridge-ma-2016-150-hardcover-or-ebook-isbn-978-0-12-802682-3
#3
https://www.readbyqxmd.com/read/28207168/design-and-rationale-of-the-ebbinghaus-trial-a-phase-3-double-blind-placebo-controlled-multicenter-study-to-assess-the-effect-of-evolocumab-on-cognitive-function-in-patients-with-clinically-evident-cardiovascular-disease-and-receiving-statin-background-lipid
#4
Robert P Giugliano, Francois Mach, Kenton Zavitz, Christopher Kurtz, Jingjing Schneider, Huei Wang, Anthony Keech, Terje R Pedersen, Marc S Sabatine, Peter S Sever, Narimon Honarpour, Scott M Wasserman, Brian R Ott
Some observational studies raised concern that statins may cause memory impairment, leading to a US Food and Drug Administration warning. Similar questions were raised regarding proprotein convertase subtilisin/kexin-type 9 inhibitors (PCSK9i) and neurocognitive function. No prospectively designed study has evaluated the relationship between long-term PCSK9i use and cognition changes. Patients with prior cardiovascular disease treated with maximally tolerated statin enrolled in FOURIER (the randomized, double-blind, placebo-controlled cardiovascular outcome study of the PCSK9i evolocumab) could participate in this prospective assessment of cognitive function (EBBINGHAUS)...
February 16, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28190990/the-translation-of-lipid-profiles-to-nutritional-biomarkers-in-the-study-of-infant-metabolism
#5
Animesh Acharjee, Philippa Prentice, Carlo Acerini, James Smith, Ieuan A Hughes, Ken Ong, Julian L Griffin, David Dunger, Albert Koulman
INTRODUCTION: Links between early life exposures and later health outcomes may, in part, be due to nutritional programming in infancy. This hypothesis is supported by observed long-term benefits associated with breastfeeding, such as better cognitive development in childhood, and lower risks of obesity and high blood pressure in later life. However, the possible underlying mechanisms are expected to be complex and may be difficult to disentangle due to the lack of understanding of the metabolic processes that differentiate breastfed infants compared to those receiving just formula feed...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28186934/protocol-for-the-mindful-student-study-a-randomised-controlled-trial-of-the-provision-of-a-mindfulness-intervention-to-support-university-students-well-being-and-resilience-to-stress
#6
Julieta Galante, Geraldine Dufour, Alice Benton, Emma Howarth, Maris Vainre, Timothy J Croudace, Adam P Wagner, Jan Stochl, Peter B Jones
INTRODUCTION: Levels of stress in UK university students are high, with an increase in the proportion of students seeking help in recent years. Academic pressure is reported as a major trigger. Mindfulness training has been shown to reduce stress and is popular among students, but its effectiveness in this context needs to be ascertained. In this pragmatic randomised controlled trial, we hypothesise that the provision of a preventative mindfulness intervention in universities could reduce students' psychological distress during the examination period (primary outcome), improve their resilience to stress up to at least 1 year later, reduce their use of mental health support services and improve academic performance...
November 9, 2016: BMJ Open
https://www.readbyqxmd.com/read/28179035/impact-of-deep-brain-stimulation-of-the-ventral-anterior-limb-of-the-internal-capsule-on-cognition-in-depression
#7
I O Bergfeld, M Mantione, M L C Hoogendoorn, H G Ruhé, F Horst, P Notten, J van Laarhoven, P van den Munckhof, G Beute, P R Schuurman, D Denys
BACKGROUND: Preliminary studies report no negative and a possible positive impact of deep brain stimulation (DBS) on cognition of patients with treatment-resistant depression (TRD). However, these studies neither controlled for practice effects nor compared active with sham stimulation. METHOD: To address these limitations, we compared 25 TRD patients, who underwent DBS of the ventral anterior limb of the internal capsule (vALIC), with 21 healthy controls (HCs) matched on gender, age and education level...
February 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28177306/validation-and-extraction-of-molecular-geometry-information-from-small-molecule-databases
#8
Fei Long, Robert A Nicholls, Paul Emsley, Saulius Graǽulis, Andrius Merkys, Antanas Vaitkus, Garib N Murshudov
A freely available small-molecule structure database, the Crystallography Open Database (COD), is used for the extraction of molecular-geometry information on small-molecule compounds. The results are used for the generation of new ligand descriptions, which are subsequently used by macromolecular model-building and structure-refinement software. To increase the reliability of the derived data, and therefore the new ligand descriptions, the entries from this database were subjected to very strict validation...
February 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28173890/differences-in-executive-functioning-between-violent-and-non-violent-offenders
#9
J Meijers, J M Harte, G Meynen, P Cuijpers
BACKGROUND: A growing body of neuropsychological and neurobiological research shows a relationship between functioning of the prefrontal cortex and criminal and violent behaviour. The prefrontal cortex is crucial for executive functions such as inhibition, attention, working memory, set-shifting and planning. A deficit in these functions - a prefrontal deficit - may result in antisocial, impulsive or even aggressive behaviour. While several meta-analyses show large effect sizes for the relationship between a prefrontal deficit, executive dysfunction and criminality, there are few studies investigating differences in executive functions between violent and non-violent offenders...
February 8, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28172540/dop079-the-role-of-intestinal-transplant-in-patients-with-complicated-inflammatory-bowel-disease-the%C3%A2-cambridge-experience
#10
S P Yeap, L M Sharkey, J M Woodward, D C Massey, S J Middleton, N K Russell, A J Butler
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28167687/prediction-of-preeclampsia-using-the-soluble-fms-like-tyrosine-kinase-1-to-placental-growth-factor-ratio-a-prospective-cohort-study-of-unselected-nulliparous-women
#11
Ulla Sovio, Francesca Gaccioli, Emma Cook, Martin Hund, D Stephen Charnock-Jones, Gordon C S Smith
We sought to assess the ratio of sFlt-1 (soluble fms-like tyrosine kinase 1) to PlGF (placental growth factor) in maternal serum as a screening test for preeclampsia in unselected nulliparous women with a singleton pregnancy. We studied 4099 women recruited to the POP study (Pregnancy Outcome Prediction) (Cambridge, United Kingdom). The sFlt-1:PlGF ratio was measured using the Roche Cobas e411 platform at ≈20, ≈28, and ≈36 weeks of gestational age (wkGA). Screen positive was defined as an sFlt-1:PlGF ratio >38, but higher thresholds were also studied...
February 6, 2017: Hypertension
https://www.readbyqxmd.com/read/28163654/epistemic-cultures-in-complementary-medicine-knowledge-making-in-university-departments-of-osteopathy-and-chinese-medicine
#12
Caragh Brosnan
There is increasing pressure on complementary and alternative medicine (CAM) to follow the evidence-based approach promoted in allied health and medicine, in which the randomised control trial represents the evidence gold standard. However, many CAM advocates see these methods as undermining the holism of CAM practice. This paper explores how such tensions are managed in CAM university departments - settings in which particular forms of knowledge and evidence are given 'official' imprimatur by CAM educators and researchers...
May 3, 2016: Health Sociology Review: the Journal of the Health Section of the Australian Sociological Association
https://www.readbyqxmd.com/read/28162928/secretin-stimulated-mri-characterization-of-pancreatic-morphology-and-function-in-patients-with-chronic-pancreatitis
#13
Adnan Madzak, Søren Schou Olesen, Ingfrid Salvesen Haldorsen, Asbjørn Mohr Drewes, Jens Brøndum Frøkjær
BACKGROUND/OBJECTIVES: Chronic pancreatitis (CP) is characterized by abnormal pancreatic morphology and impaired endocrine and exocrine function. However, little is known about the relationship between pancreatic morphology and function, and also the association with the etiology and clinical manifestations of CP. The aim was to explore pancreatic morphology and function with advanced MRI in patients with CP and healthy controls (HC) METHODS: Eighty-two patients with CP and 22 HC were enrolled in the study...
January 27, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28155072/challenges-in-determining-intrinsic-viscosity-under-low-ionic-strength-solution-conditions
#14
Mariya A Pindrus, Steven J Shire, Sandeep Yadav, Devendra S Kalonia
PURPOSE: To determine the intrinsic viscosity of several monoclonal antibodies (mAbs) under varying pH and ionic strength solution conditions. METHODS: An online viscosity detector attached to HPLC (Viscotek®) was used to determine the intrinsic viscosity of mAbs. The Ross and Minton equation was used for viscosity prediction at high protein concentrations. Bulk viscosity was determined by a Cambridge viscometer. RESULTS: At 15 mM ionic strength, intrinsic viscosity of the mAbs determined by the single-point approach varied from 5...
February 2, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28151002/lack-of-associations-between-modifiable-risk-factors-and-dementia-in-the-very-old-findings-from-the-cambridge-city-over-75s-cohort-study
#15
Kay Deckers, Sebastian Köhler, Martin van Boxtel, Frans Verhey, Carol Brayne, Jane Fleming
OBJECTIVES: To investigate the association between modifiable risk and protective factors and severe cognitive impairment and dementia in the very old. Additionally, the present study tests the predictive validity of the 'LIfestyle for BRAin health' (LIBRA) score, an index developed to assess an individual's dementia prevention potential. METHOD: Two hundred seventy-eight individuals aged 85 years or older from the Cambridge City over-75s cohort study were followed-up until death...
February 2, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28149333/the-epigenomic-basis-of-common-diseases
#16
Euan J Rodger, Aniruddha Chatterjee
A report of the 6(th) Epigenomics of Common Diseases Conference held at the Wellcome Genome Campus in Hinxton, Cambridge, UK, on 1-4 November 2016.
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28148738/cell-scientist-to-watch-andrew-holland
#17
(no author information available yet)
Andrew received his first degree in natural sciences from the University of Cambridge and a Masters degree from the University of Manchester, followed by a PhD with Stephen Taylor in Manchester. He then moved to California in 2007 with an EMBO long-term fellowship for his postdoctoral research with Don Cleveland at the Ludwig Institute for Cancer Research. In 2013, Andrew started his own lab as an Assistant Professor in the Department of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine, having been named a Kimmel Scholar and a Pew-Stewart Scholar in 2014...
February 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28147555/the-influence-of-finite-and-infinite-wall-cavities-on-the-sound-insulation-of-double-leaf-walls
#18
Jason E Cambridge, John L Davy, John Pearse
Theories used to predict the sound insulation of double-leaf cavity wall systems are usually based on the assumption that the wall is of an infinite extent. To account for the effect of the finite extent of the wall, limiting the angle of incidence, a finite radiation efficiency model or the spatial windowing method is used in order to obtain realistic predictions. However, the effects of the finite extent of the cavity are often not included. This paper presents an extension of a finite two-dimensional cavity theory to include limp panels on each side of the cavity...
January 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28145945/training-internal-medicine-residents-in-social-medicine-and-research-based-health-advocacy-a-novel-in-depth-curriculum
#19
Gaurab Basu, Richard J Pels, Rachel L Stark, Priyank Jain, David H Bor, Danny McCormick
PROBLEM: Health disparities are pervasive worldwide. Physicians have a unique vantage point from which they can observe the ways social, economic, and political factors impact health outcomes and can be effective advocates for enhanced health outcomes and health equity. However, social medicine and health advocacy curricula are uncommon in postgraduate medical education. APPROACH: In academic year (AY) 2012, the Cambridge Health Alliance internal medicine residency program transformed an elective into a required social medicine and research-based health advocacy curriculum...
January 31, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28140834/validation-of-a-standalone-smartphone-application-for-measuring-heart-rate-using-imaging-photoplethysmography
#20
Ming-Zher Poh, Yukkee C Poh
BACKGROUND: The aim of this study was to determine the accuracy of a freely available smartphone application, Cardiio app (Cardiio, Inc., Cambridge, MA), to measure heart rate from the finger or face using imaging photoplethysmography, by comparing against an FDA-cleared pulse oximeter at rest, and after moderate to vigorous exercise. METHODS: A total of 40 healthy adults participated in this study. Participants engaged in a period of rest, followed by 3 min of moderate to vigorous intensity cycling on a stationary bicycle...
January 31, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
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