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https://www.readbyqxmd.com/read/29166814/book-review-nanoparticles-and-the-immune-system-safety-and-effects-boraschi-diana-duschl-albert-eds-nanoparticles-and-the-immune-system-safety-and-effects-academic-press-cambridge-massachusetts-usa-2014-138-pp-49-95-paperback-isbn-9780124080850-49-95-ebook
#1
https://www.readbyqxmd.com/read/29164349/the-influence-of-solvent-on-conformational-properties-of-peptides-with-aib-residue-a-dft-study
#2
Roksana Wałęsa, Małgorzata A Broda
The conformational propensities of the Aib residue on the example of two model peptides Ac-Aib-NHMe (1) and Ac-Aib-NMe2 (2), were studied by B3LYP and M06-2X functionals, in the gas phase and in the polar solvents. To verify the reliability of selected functionals, we also performed MP2 calculations for the tested molecules in vacuum. Polarizable continuum models (PCM and SMD) were used to estimate the solvent effect. Ramachandran maps were calculated to find all energy minima. Noncovalent intramolecular interactions due to hydrogen-bonds and dipole attractions between carbonyl groups are responsible for the relative stabilities of the conformers...
November 21, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29162576/functional-visual-fields-a-cross-sectional-uk-study-to-determine-which-visual-field-paradigms-best-reflect-difficulty-with-mobility-function
#3
Hikmat Subhi, Keziah Latham, Joy Myint, Michael Crossland
OBJECTIVES: To develop an appropriate method of assessing visual field (VF) loss which reflects its functional consequences, this study aims to determine which method(s) of assessing VF best reflect mobility difficulty. SETTING: This cross-sectional observational study took place within a single primary care setting. Participants attended a single session at a University Eye Clinic, Cambridge, UK, with data collected by a single researcher (HS), a qualified optometrist...
November 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/29161919/the-effects-of-adhd-on-cognitive-performance
#4
Emma Claesdotter, Matti Cervin, Sofia Åkerlund, Maria Råstam, Magnus Lindvall
BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) is a common and impairing neurodevelopmental disorder. The Cambridge Neuropsychological Test Automated Battery (CANTAB) is a computerized test battery with standardized procedures and solid psychometric properties targeting multiple neuropsychological functions. AIMS: The aim of this study was to look at the effects of ADHD on cognitive performance using CANTAB expressed as a statistical interaction term in regression modeling...
November 21, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29158822/liposomal-64-cu-pet-imaging-of-anti-vegf-drug-effects-on-liposomal-delivery-to-colon-cancer-xenografts
#5
Stephanie J Blocker, Kirk A Douglas, Lisa Anne Polin, Helen Lee, Bart S Hendriks, Enxhi Lalo, Wei Chen, Anthony F Shields
Liposomes (LP) deliver drug to tumors due to enhanced permeability and retention (EPR). LP were labeled with (64)Cu for positron emission tomography (PET) to image tumor localization. Bevacizumab (bev), a VEGF targeted antibody, may modify LP delivery by altering tumor EPR and this change can also be imaged. Objective: Assess the utility of (64)Cu-labeled LP for PET in measuring altered LP delivery early after treatment with bev. Methods: HT-29 human colorectal adenocarcinoma tumors were grown subcutaneously in SCID mice...
2017: Theranostics
https://www.readbyqxmd.com/read/29154287/did-you-know-that-your-animals-have-consciousness
#6
P A Accorsi, E Mondo, M Cocchi
Consciousness is the greatest enigma in human history. For centuries scientists and researchers have tried to describe it without coming to conclusions. In the last years with the neurosciences development, consciousness has become the common goal of numerous studies. But consciousness has always been studied only in humans, but after "Cambridge Declaration on Consciousness" in 2012, even non-human animalsthey feel possessed of the consciousness. According to "theory Orch-OR" of Hameroff and Penrose we have conducted a study on Alaskan malamute and German shepherd to analysed a triplet of platelet fatty acids (linoleic acid; palmitic acid; arachidonic acid)...
November 14, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/29153680/associations-between-bacterial-infections-and-blood-pressure-in-pregnancy
#7
Clive J Petry, Ken K Ong, Ieuan A Hughes, Carlo L Acerini, David B Dunger
OBJECTIVES: To test the hypothesis that bacterial infections in pregnancy are related to maternal blood pressure. STUDY DESIGN: Bacterial infection was assessed using antibiotic usage as a surrogate and its association with blood pressure in pregnancy tested in the Cambridge Baby Growth Study. MAIN OUTCOME MEASURES: Antibiotic usage in pregnancy was self-reported in questionnaires. Blood pressure measurements at four time points in pregnancy were collected from the hospital notes of 622 women...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29150294/small-groups-open-doors-fostering-individual-and-group-creativity-within-research-communities
#8
EDITORIAL
Thomas C Erren, David M Shaw, Philip Lewis
While abundant publications attempt to analyze and understand what makes humans creative, much less attention is being paid to institutional conditions which may enhance or impede creative work. On the basis of evidence from Cambridge and AT&T's Bell Laboratories, and as a condensation of the Janelia Experiment, an institutional focus on "small groups" and "open doors" may foster individual and group creativity. The evidence suggests that small organizational units of up to seven scientists and open door concepts could nurture interactions within and between groups and enhance the critical mass for individual and group creativity...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29147945/stephen-hilgartner-reordering-life-knowledge-and-control-in-the-genomics-revolution-cambridge-massachusetts-the-mit-press-2017-xiv%C3%A2-%C3%A2-343%C3%A2-pp-may-2017-35-00-%C3%A2-27-95
#9
James W E Lowe
No abstract text is available yet for this article.
November 16, 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/29144185/rest-activity-circadian-rhythm-and-sleep-quality-in-patients-with-binge-eating-disorder
#10
E Roveda, A Montaruli, L Galasso, C Pesenti, E Bruno, P Pasanisi, M Cortellini, S Rampichini, S Erzegovesi, A Caumo, F Esposito
Recent findings suggest that altered rest-activity circadian rhythms (RARs) are associated with a compromised health status. RARs abnormalities have been observed also in several pathological conditions, such as cardiovascular, neurological, and cancer diseases. Binge eating disorder (BED) is the most common eating disorder, with a prevalence of 3.5% in women and 2% in men. BED and its associate obesity and motor inactivity could induce RARs disruption and have negative consequences on health-related quality of life...
November 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29138654/syphilis-and-hiv-infections-among-pregnant-women-attending-antenatal-clinics-in-republic-of-congo
#11
Roch Fabien Niama, Nadia Claricelle Loukabou Bongolo, Edith Sophie Bayonne Kombo, Ruth Yengo, Pembe Issamou Mayengue, Etoka-Beka Mandingha Kosso, Igor Louzolo, Lucette Macosso, Ghislain Dzeret, Angélie Serge Patrick Dzabatou Babeaux, Marie-Francke Puruehnce, Henri Joseph Parra
Introduction: HIV and syphilis during pregnancy remain a public health concern especially in developing countries. Pregnant women attending antenatal clinics sites for the first time between September and December 2011 and who accepted to participate in the study were enrolled. The objective was to estimate the syphilis and HIV infection rate in this population. Methods: A study was conducted in 44 selected ANCs from 12 departments (5 urban and 7 rural). Pregnant women who accepted to participate in the study, attending selected sentinel ANCs sites for the first time between September and December 2011 were enrolled...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29134834/book-review-rights-come-to-mind-brain-injury-ethics-and-the-struggle-for-consciousness-rights-come-to-mind-brain-injury-ethics-and-the-struggle-for-consciousness-by-fins-joseph-j-new-york-cambridge-university-press-2015-xvi-379-pp-28-99-paperback
#12
https://www.readbyqxmd.com/read/29130373/book-review-youval-rotman-insanity-and-sanctity-in-byzantium-the-ambiguity-of-religious-experience-rotman-youval-insanity-and-sanctity-in-byzantium-the-ambiguity-of-religious-experience-harvard-university-press-cambridge-ma-2016-256-pp-9780674057616-29-95-hbk
#13
https://www.readbyqxmd.com/read/29128118/associations-between-inflammatory-markers-and-cognitive-function-in-breast-cancer-patients-receiving-chemotherapy
#14
AnnaLynn M Williams, Raven Shah, Michelle Shayne, Alissa J Huston, Marcia Krebs, Nicole Murray, Bryan D Thompson, Kassandra Doyle, Jenna Korotkin, Edwin van Wijngaarden, Sharon Hyland, Jan A Moynihan, Deborah A Cory-Slechta, Michelle C Janelsins
BACKGROUND: Cancer-related cognitive impairment (CRCI) is often related to chemotherapy. Increased chronic inflammation is believed to play a key role in the development of CRCI related to chemotherapy but studies assessing this hypothesis specifically in patients receiving chemotherapy are rare. METHODS: We assessed several cognitive domains using the Cambridge Neuropsychological Test Automated Battery (CANTAB) in twenty-two breast cancer patients currently receiving chemotherapy...
October 18, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29126206/the-incidence-and-origin-of-segmental-aneuploidy-in-human-oocytes-and-preimplantation-embryos
#15
D Babariya, E Fragouli, S Alfarawati, K Spath, D Wells
STUDY QUESTION: What is the incidence, origin and clinical significance of segmental aneuploidy in human oocytes and preimplantation embryos? SUMMARY ANSWER: Segmental aneuploidy occurs at a considerable frequency in preimplantation embryos with a majority being mitotic in origin. WHAT IS KNOWN ALREADY: In recent years, accurate techniques for the detection of aneuploidy in single cells have been developed. Research using such methods has confirmed that aneuploidy is a common feature of human oocytes and preimplantation embryos...
November 8, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29124462/polymorphisms-of-mitochondrial-dna-control-region-are-associated-to-endometriosis
#16
Marina Paula Andres, Mari Maki Siria Godoy Cardena, Cintia Fridman, Sergio Podgaec
PURPOSE: Polymorphisms in the control region of mitochondrial DNA (mtDNA) can affect generation of reactive oxygen species and impact in the pathogenesis of endometriosis. This study investigated the association of mtDNA polymorphisms with endometriosis. METHODS: Patients were divided in two groups: endometriosis (n = 90) and control (n = 92). Inclusion criteria were as follows: women between 18 and 50 years, with histological diagnosis and surgical staging of endometriosis (endometriosis group) or undergoing gynecological surgery for tubal ligation, leiomyoma, or ovarian cysts, with no evidence of endometriosis (control group)...
November 9, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29119797/alexithymia-predicts-loss-chasing-for-people-at-risk-for-problem-gambling
#17
Peter A Bibby, Katherine E Ross
Background and aims The aim of this research was to investigate the relationship between alexithymia and loss-chasing behavior in people at risk and not at risk for problem gambling. Methods An opportunity sample of 58 (50 males and 8 females) participants completed the Problem Gambling Severity Index and the Toronto Alexithymia Scale (TAS-20). They then completed the Cambridge Gambling Task from which a measure of loss-chasing behavior was derived. Results Alexithymia and problem gambling risk were significantly positively correlated...
November 9, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29118833/in-patient-physiotherapy-for-adults-on-veno-venous-extracorporeal-membrane-oxygenation-united-kingdom-ecmo-physiotherapy-network-a-consensus-agreement-for-best-practice
#18
Allaina Eden, Claire Purkiss, Gabriella Cork, Adam Baddeley, Kelly Morris, Leah Carey, Mike Brown, Laura McGarrigle, Samantha Kennedy
Clinical specialist physiotherapists from the five severe respiratory failure centres in England where respiratory extracorporeal membrane oxygenation (ECMO) is practiced have established this consensus agreement for physiotherapy best practice. The severe respiratory failure centres are Wythenshawe Hospital, Manchester; Glenfield Hospital, Leicester; Papworth Hospital, Cambridge; Guy's and St Thomas' Hospital, London and The Royal Brompton Hospital, London. Although research into physiotherapy and ECMO is increasing, there is not a sufficient amount to write evidence-based guidelines; hence the development of a consensus document, using knowledge and experience of the specialist physiotherapists working with patients receiving ECMO...
August 2017: J Intensive Care Soc
https://www.readbyqxmd.com/read/29118635/a-new-species-of-monstrillopsis-crustacea-copepoda-monstrilloida-from-the-lower-northwest-passage-of-the-canadian-arctic
#19
Aurélie Delaforge, Eduardo Suárez-Morales, Wojciech Walkusz, Karley Campbell, C J Mundy
A new species of monstrilloid copepod, Monstrillopsis planifronssp. n., is described from an adult female that was collected beneath snow-covered sea ice during the 2014 Ice Covered Ecosystem - CAMbridge bay Process Study (ICE-CAMPS) in Dease Strait of the Canadian Arctic Archipelago. Currently, up to six species of this order are known to occur in polar latitudes. The new species described herein shares similarities with Monstrillopsis dubia (Scott, 1904) but differs in its body proportions and cephalothorax ornamentation; the cephalothorax is covered by minute scattered papillae on dorsal and ventral surfaces; this species has a reduced fifth leg endopod, fifth leg exopod armed with three setae, antennule with fused segments 3-4, and the genital double-somite bears unique posterolateral processes...
2017: ZooKeys
https://www.readbyqxmd.com/read/29113277/sequence-variations-of-mitochondrial-dna-d-loop-region-in-patients-with-acute-myeloid-leukemia
#20
Juan Zhou, Haimei Gou, Yuanxin Ye, Yi Zhou, Xiaojun Lu, Binwu Ying
The aim of the present study was to explore variations of the displacement (D)-loop region in patients with acute myeloid leukemia (AML) and their possible associations with AML pathogenesis. Blood or bone marrow samples from 216 patients with AML (158 AML patients in the first stage, and 58 more patients with AML-M3 for further verification), and 146 healthy controls were collected. Sanger sequencing was performed for the D-loop region ranging between nucleotide (nt)15811 and nt 775. With the exception of mitochondrial microsatellite instability (mtMSI) variations, a total of 2,630 variations in 232 loci were identified with similar variation rates/person in patients with AML and controls when compared with the revised Cambridge reference sequence (8...
November 2017: Oncology Letters
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