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https://www.readbyqxmd.com/read/29777691/improving-electrical-properties-of-ipsc-cardiomyocytes-by-enhancing-cx43-expression
#1
Valentin Sottas, Carl-Mattheis Wahl, Mihnea C Trache, Michael Bartolf-Kopp, Sidney Cambridge, Markus Hecker, Nina D Ullrich
The therapeutic potential of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is limited by immature functional features including low impulse propagation and reduced cell excitability. Key players regulating electrical activity are voltage-gated Na+ channels (Nav 1.5) and gap junctions built from connexin-43 (Cx43). Here we tested the hypothesis that enhanced Cx43 expression increases intercellular coupling and influences excitability by modulating Nav 1.5. Using transgenic approaches, Cx43 and Nav 1...
May 16, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29777464/the-key-features-approach-to-assess-clinical-decisions-validity-evidence-to-date
#2
REVIEW
G Bordage, G Page
The key-features (KFs) approach to assessment was initially proposed during the First Cambridge Conference on Medical Education in 1984 as a more efficient and effective means of assessing clinical decision-making skills. Over three decades later, we conducted a comprehensive, systematic review of the validity evidence gathered since then. The evidence was compiled according to the Standards for Educational and Psychological Testing's five sources of validity evidence, namely, Content, Response process, Internal structure, Relations to other variables, and Consequences, to which we added two other types related to Cost-feasibility and Acceptability...
May 17, 2018: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/29773959/conservation-systematics-of-the-shield-backed-trapdoor-spiders-of-the-nigrum-group-mygalomorphae-idiopidae-idiosoma-integrative-taxonomy-reveals-a-diverse-and-threatened-fauna-from-south-western-australia
#3
Michael G Rix, Joel A Huey, Steven J B Cooper, Andrew D Austin, Mark S Harvey
The aganippine shield-backed trapdoor spiders of the monophyletic nigrum -group of Idiosoma Ausserer s. l. are revised, and 15 new species are described from Western Australia and the Eyre Peninsula of South Australia: I. arenaceum Rix & Harvey, sp. n. , I. corrugatum Rix & Harvey, sp. n. , I. clypeatum Rix & Harvey, sp. n. , I. dandaragan Rix & Harvey, sp. n. , I. formosum Rix & Harvey, sp. n. , I. gardneri Rix & Harvey, sp. n. , I. gutharuka Rix & Harvey, sp. n. , I. incomptum Rix & Harvey, sp...
2018: ZooKeys
https://www.readbyqxmd.com/read/29772392/effects-of-task-repetition-but-no-transfer-of-inhibitory-control-training-in-healthy-adults
#4
Tobias Talanow, Ulrich Ettinger
Executive functions (EFs) comprise the updating, shifting and inhibition dimensions. According to the Unity and Diversity Model, the inhibition dimension is fully accounted for by a general EFs factor. This suggests that training of inhibition should transfer, in part, to updating and shifting. Therefore, we tested the effectiveness of a three-week inhibition training (high-conflict Stroop task) and explored near transfer effects to an untrained inhibition task (antisaccade task) and far transfer effects to untrained tasks demanding task-set shifting (number-letter-task), working memory updating (n-back task) and planning abilities (Stockings of Cambridge task)...
May 14, 2018: Acta Psychologica
https://www.readbyqxmd.com/read/29771615/risk-and-protective-factors-for-intimate-partner-violence-against-women-systematic-review-and-meta-analyses-of-prospective-longitudinal-studies
#5
Alexa R Yakubovich, Heidi Stöckl, Joseph Murray, G J Melendez-Torres, Janina I Steinert, Calla E Y Glavin, David K Humphreys
BACKGROUND: The estimated lifetime prevalence of physical or sexual intimate partner violence (IPV) is 30% among women worldwide. Understanding risk and protective factors is essential for designing effective prevention strategies. OBJECTIVES: To quantify the associations between prospective-longitudinal risk and protective factors and IPV and identify evidence gaps. SEARCH METHODS: We conducted systematic searches in 16 databases including MEDLINE and PsycINFO from inception to June 2016...
May 17, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29769713/author-correction-discovery-of-a-selective-catalytic-p300-cbp-inhibitor-that-targets-lineage-specific-tumours
#6
Loren M Lasko, Clarissa G Jakob, Rohinton P Edalji, Wei Qiu, Debra Montgomery, Enrico L Digiammarino, T Matt Hansen, Roberto M Risi, Robin Frey, Vlasios Manaves, Bailin Shaw, Mikkel Algire, Paul Hessler, Lloyd T Lam, Tamar Uziel, Emily Faivre, Debra Ferguson, Fritz G Buchanan, Ruth L Martin, Maricel Torrent, Gary G Chiang, Kannan Karukurichi, J William Langston, Brian T Weinert, Chunaram Choudhary, Peter de Vries, Arthur F Kluge, Michael A Patane, John H Van Drie, Ce Wang, David McElligott, Edward A Kesicki, Ronen Marmorstein, Chaohong Sun, Philip A Cole, Saul H Rosenberg, Michael R Michaelides, Albert Lai, Kenneth D Bromberg
In the originally published version of this Letter, the authors Arthur F. Kluge, Michael A. Patane and Ce Wang were inadvertently omitted from the author list. Their affiliations are: I-to-D, Inc., PO Box 6177, Lincoln, Massachusetts 01773, USA (A.F.K.); Mitobridge, Inc. 1030 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA (M.A.P.); and China Novartis Institutes for BioMedical Research, No. 4218 Jinke Road, Zhangjiang Hi-Tech Park, Pudong District, Shanghai 201203, China (C.W.). These authors contributed to the interpretation of results and design of compounds...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29767745/preconception-maternal-iodine-status-is-positively-associated-with-iq-but-not-with-measures-of-executive-function-in-childhood
#7
Sian M Robinson, Sarah R Crozier, Elizabeth A Miles, Catharine R Gale, Philip C Calder, Cyrus Cooper, Hazel M Inskip, Keith M Godfrey
Background: Adverse effects of severe maternal iodine deficiency in pregnancy on fetal brain development are well-established, but the effects of milder deficiency are uncertain. Most studies examine iodine status in pregnancy; less is known about iodine nutrition before conception. Objective: We examined relations between maternal preconception iodine status and offspring cognitive function, within a prospective mother-offspring cohort. Methods: Maternal iodine status was assessed through the use of the ratio of iodine:creatinine concentrations (I/Cr) in spot urine samples [median (IQR) period before conception 3...
May 15, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29765601/survey-and-analysis-of-crystal-polymorphism-in-organic-structures
#8
Kortney Kersten, Ramanpreet Kaur, Adam Matzger
With the intention of producing the most comprehensive treatment of the prevalence of crystal polymorphism among structurally characterized materials, all polymorphic compounds flagged as such within the Cambridge Structural Database (CSD) are analysed and a list of crystallographically characterized organic polymorphic compounds is assembled. Classifying these structures into subclasses of anhydrates, salts, hydrates, non-hydrated solvates and cocrystals reveals that there are significant variations in polymorphism prevalence as a function of crystal type, a fact which has not previously been recognized in the literature...
March 1, 2018: IUCrJ
https://www.readbyqxmd.com/read/29764522/treatment-resistant-depression-and-peripheral-c-reactive-protein
#9
Samuel R Chamberlain, Jonathan Cavanagh, Peter de Boer, Valeria Mondelli, Declan N C Jones, Wayne C Drevets, Philip J Cowen, Neil A Harrison, Linda Pointon, Carmine M Pariante, Edward T Bullmore
BACKGROUND: C-reactive protein (CRP) is a candidate biomarker for major depressive disorder (MDD), but it is unclear how peripheral CRP levels relate to the heterogeneous clinical phenotypes of the disorder.AimTo explore CRP in MDD and its phenotypic associations. METHOD: We recruited 102 treatment-resistant patients with MDD currently experiencing depression, 48 treatment-responsive patients with MDD not currently experiencing depression, 48 patients with depression who were not receiving medication and 54 healthy volunteers...
May 16, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29762534/tetrel-bonds-with-%C3%AF-electrons-acting-as-lewis-bases-theoretical-results-and-experimental-evidences
#10
Sławomir J Grabowski
MP2/aug-cc-pVTZ calculations were carried out for the ZFH₃-B complexes (Z = C, Si, Ge, Sn and Pb; B = C₂H₂, C₂H₄, C₆H₆ and C₅H₅⁻; relativistic effects were taken into account for Ge, Sn and Pb elements). These calculations are supported by other approaches; the decomposition of the energy of interaction, Quantum Theory of Atoms in Molecules (QTAIM) and Natural Bond Orbital (NBO) method. The results show that tetrel bonds with π-electrons as Lewis bases are classified as Z···C links between single centers (C is an atom of the π-electron system) or as Z···π interactions where F‒Z bond is directed to the mid-point (or nearly so) of the CC bond of the Lewis base...
May 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29761265/snait-b-gissis-ehud-lamm-and-ayelet-shavit-eds-landscapes-of-collectivity-in-the-life-sciences-cambridge-ma-the-mit-press-2017-xv-415-pp-60-%C3%A2-49-95-42-00-paperback
#11
Javier Suárez
No abstract text is available yet for this article.
May 14, 2018: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/29761191/highlights-from-the-faraday-discussion-on-ionic-liquids-from-fundamental-properties-to-practical-applications-cambridge-uk-september-2017
#12
Leigh Aldous, Magdalena Bendova, Maria Gonzalez-Miquel, Małgorzata Swadźba-Kwaśny
For the third time, a Faraday Discussion addressed ionic liquids. Encompassing the wealth of research in this field, the contributions ranged from fundamental insights to the diverse applications of ionic liquids. Lively discussions initiated in the lecture hall and during poster sessions then seamlessly continued during the social program.
May 15, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29755747/structural-studies-of-crystalline-forms-of-triamterene-with-carboxylic-acid-gras-and-api-molecules
#13
Abida Rehman, Amit Delori, David S Hughes, William Jones
Pharmaceutical salt solvates (dimethyl sulfoxide, DMSO) of the drug triamterene with the coformers acetic, succinic, adipic, pimelic, azelaic and nicotinic acid and ibuprofen are prepared by liquid-assisted grinding and solvent-evaporative crystallization. The modified Δp K a rule as proposed by Cruz-Cabeza [(2012 ▸). CrystEngComm , 14 , 6362-6365] is in close agreement with the results of this study. All adducts were characterized by X-ray diffraction and thermal analytical techniques, including single-crystal X-ray diffraction, powder X-ray diffraction, differential scanning calorimetry and thermal gravimetric analysis...
May 1, 2018: IUCrJ
https://www.readbyqxmd.com/read/29750153/health-related-quality-of-life-in-pulmonary-hypertension-and-its-clinical-correlates-a-cross-sectional-study
#14
Abílio Reis, Mário Santos, Margarida Vicente, Inês Furtado, Célia Cruz, Alzira Melo, Luísa Carvalho, Fabienne Gonçalves, Pedro Sa-Couto, Luís Almeida
Background: Health-related quality of life (HRQoL) impairment is common in pulmonary hypertension (PH), but its clinical predictors are not well established. This study aims to characterize the HRQoL of patients with pulmonary arterial hypertension (PAH) and other precapillary forms of PH (pcPH) and to explore its clinical correlates. Materials and Methods: A cross-sectional, observational study of patients with documented PAH and other forms of pcPH. Patients completed two patient-reported outcome measures (PROM): Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) and Nottingham Health Profile (NHP)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29749060/visual-processing-as-a-potential-endophenotype-in-youths-with-attention-deficit-hyperactivity-disorder-a-sibling-study-design-using-the-counting-stroop-functional-mri
#15
Li-Ying Fan, Chi-Yung Shang, Wen-Yih Isaac Tseng, Susan Shur-Fen Gau, Tai-Li Chou
Deficits in inhibitory control and visual processing are common in youths with attention-deficit/hyperactivity disorder (ADHD), but little is known about endophenotypes for unaffected siblings of youths with ADHD. This study aimed to investigate the potential endophenotypes of brain activation and performance in inhibitory control and visual processing among ADHD probands, their unaffected siblings, and neurotypical youths. We assessed 27 ADHD probands, 27 unaffected siblings, and 27 age-, gender-, and IQ-matched neurotypical youths using the counting Stroop functional magnetic resonance imaging and two tasks of the Cambridge Neuropsychological Test Automated Battery (CANTAB): rapid visual information processing (RVP) for inhibitory control and spatial span (SSP) for visual processing...
May 10, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29745942/chelated-metal-ions-modulate-the-strength-and-geometry-of-stacking-interactions-energies-and-potential-energy-surfaces-for-chelate-chelate-stacking
#16
Dušan P Malenov, SneŽana D Zarić
Quantum chemical calculations were performed on model systems of stacking interactions between the acac type chelate rings of nickel, palladium, and platinum. CCSD(T)/CBS calculations showed that chelate-chelate stacking interactions are significantly stronger than chelate-aryl and aryl-aryl stacking interactions. Interaction energy surfaces were calculated at the LC-ωPBE-D3BJ/aug-cc-pVDZ level, which gives energies in good agreement with CCSD(T)/CBS. The stacking of chelates in an antiparallel orientation is stronger than the stacking in a parallel orientation, which is in agreement with the larger number of antiparallel stacked chelates in crystal structures from the Cambridge Structural Database...
May 10, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29734952/arachidonic-acid-and-dha-status-in-pregnant-women-is-not-associated-with-cognitive-performance-of-their-children-at-4-or-6-7-years
#17
Sarah R Crozier, Charlene M Sibbons, Helena L Fisk, Keith M Godfrey, Philip C Calder, Catharine R Gale, Sian M Robinson, Hazel M Inskip, Janis Baird, Nicholas C Harvey, Cyrus Cooper, Graham C Burdge
Arachidonic acid (ARA) and DHA, supplied primarily from the mother, are required for early development of the central nervous system. Thus, variations in maternal ARA or DHA status may modify neurocognitive development. We investigated the relationship between maternal ARA and DHA status in early (11·7 weeks) or late (34·5 weeks) pregnancy on neurocognitive function at the age of 4 years or 6-7 years in 724 mother-child pairs from the Southampton Women's Survey cohort. Plasma phosphatidylcholine fatty acid composition was measured in early and late pregnancy...
May 8, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29730994/initial-validation-of-a-transdiagnostic-compulsivity-questionnaire-the-cambridge-chicago-compulsivity-trait-scale
#18
Samuel R Chamberlain, Jon E Grant
OBJECTIVE: Compulsivity refers to a tendency toward repetitive habitual behaviors. Multiple disorders have compulsive symptoms at their core, including substance use disorders, gambling disorder, and obsessive-compulsive disorder. The aim of this study was to validate a scale for the objective, transdiagnostic measurement of compulsivity. METHODS: The 15-item Cambridge-Chicago Compulsivity Trait Scale (CHI-T) was developed for the rapid but comprehensive measurement of compulsivity...
May 7, 2018: CNS Spectrums
https://www.readbyqxmd.com/read/29730492/trade-off-of-cerebello-cortical-and-cortico-cortical-functional-networks-for-planning-in-6-year-old-children
#19
Judy A Kipping, Daniel S Margulies, Simon Eickhoff, Annie Lee, Anqi Qiu
Childhood is a critical period for the development of cognitive planning. There is a lack of knowledge on its neural mechanisms in children. This study aimed to examine cerebello-cortical and cortico-cortical functional connectivity in association with planning skills in 6-year-olds (n = 76). We identified the cerebello-cortical and cortico-cortical functional networks related to cognitive planning using activation likelihood estimation (ALE) meta-analysis on existing functional imaging studies on spatial planning, and data-driven independent component analysis (ICA) of children's resting-state functional MRI (rs-fMRI)...
May 3, 2018: NeuroImage
https://www.readbyqxmd.com/read/29729847/siope-brain-tumor-group-consensus-guideline-on-craniospinal-target-volume-delineation-for-high-precision-radiotherapy
#20
Thankamma Ajithkumar, Gail Horan, Laetitia Padovani, Nicky Thorp, Beate Timmermann, Claire Alapetite, Lorenza Gandola, Monica Ramos, Karen Van Beek, Melissa Christiaens, Yasmin Lassen-Ramshad, Henriette Magelssen, Kristina Nilsson, Frank Saran, Barbara Rombi, Rolf Kortmann, Geert O Janssens
OBJECTIVE: To develop a consensus guideline for craniospinal target volume (TV) delineation in children and young adults participating in SIOPE studies in the era of high-precision radiotherapy. METHODS AND MATERIALS: During four consensus meetings (Cambridge, Essen, Liverpool, and Marseille), conventional field-based TV has been translated into image-guided high-precision craniospinal TV by a group of expert paediatric radiation oncologists and enhanced by MRI images of liquor distribution...
May 2, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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