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https://www.readbyqxmd.com/read/29341417/synthesis-and-characterization-of-photoactivatable-doxycycline-analogues-bearing-two-photon-sensitive-photoremovable-groups-suitable-for-light-induced-gene-expression
#1
Alexandre Specht, Bastien Goegan, Firat Terzi, Frédéric Bolze, Sidney Cambridge
We report herein the synthesis and the photolytic properties of EANBP and PEG7-DEACM caged 9-aminodoxycycline. 9-Aminodoxycycline is a tetracycline analogue able to activate transcription via the inducible TetOn transgene expression system and can be regioselectively coupled by carbamoylation to two-photon sensitive photoremovable protecting groups. The EANBP caged 9-aminodoxycycline showed complex photochemical reactions but did release 10% of 9-aminodoxycycline. However, the PEG7-DEACM-9-aminodoxycycline exhibited excellent photolysis efficiency at 405 nm with a quantitative release of 9-aminodoxycycline and a 0...
January 17, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29336598/quantitative-mr-evaluation-of-chronic-pancreatitis-extracellular-volume-fraction-and-mr-relaxometry
#2
Temel Tirkes, Chen Lin, Enming Cui, Yu Deng, Paul R Territo, Kumaresan Sandrasegaran, Fatih Akisik
OBJECTIVE: The purpose of this study was to determine if extracellular volume fraction and T1 mapping can be used to diagnose chronic pancreatitis (CP). MATERIALS AND METHODS: This HIPAA-compliant study analyzed 143 consecutive patients with and without CP who underwent MR imaging between May 2016 and February 2017. Patients were selected for the study according to inclusion and exclusion criteria that considered history and clinical and laboratory findings. Eligible patients (n = 119) were grouped as normal (n = 60) or with mild (n = 22), moderate (n = 27), or severe (n = 10) CP on the basis of MRCP findings using the Cambridge classification as the reference standard...
January 16, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29333883/simultaneous-intestinal-and-kidney-transplantation-in-adults
#3
Irum Amin, Charlotte Rutter, Adam Barlow, Neil K Russell, J Andrew Bradley, Andrew Jackson, Andrew J Butler
AIM OF THE STUDY: Intestinal transplantation (IT) is a life-saving procedure for carefully selected patients with intestinal failure. We evaluated patients who had undergone simultaneous intestinal and kidney transplantation (SIKT) to determine whether UK guidelines for inclusion of a renal allograft (dialysis dependent or estimated glomerular filtration rate ((eGFR)) < 45 ml/min/1.73 m2) are justified. METHODS: A single centre analysis was undertaken of adults undergoing IT at the Cambridge Transplant Centre between December 2007 and January 2016...
January 15, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29333611/cognitive-dysfunction-after-generalized-tonic-clonic-status-epilepticus-in-adults
#4
K N Power, A Gramstad, N E Gilhus, K O Hufthammer, B A Engelsen
OBJECTIVES: Generalized tonic-clonic status epilepticus (GTC-SE) is considered a risk for cognitive impairment. Research with standardized tools is scarce and non-conclusive. We systematically assessed short-term and long-term cognitive function after GTC-SE. MATERIALS AND METHODS: Thirty-three patients were tested after the clinical post-ictal phase of GTC-SE (timepoint 1) and again after 1 year (timepoint 2). Twenty controls were examined with the same tests...
January 14, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29332120/severe-loss-of-tritan-color-discrimination-in-rpe65-associated-leber-congenital-amaurosis
#5
Neruban Kumaran, Caterina Ripamonti, Angelos Kalitzeos, Gary S Rubin, James W B Bainbridge, Michel Michaelides
Purpose: RPE65-associated Leber congenital amaurosis (RPE65-LCA) is a progressive severe retinal dystrophy with early profound dysfunction of rod photoreceptors followed by progressive cone photoreceptor degeneration. We aim to provide detailed information about how cone dysfunction affects color discrimination. Methods: Seven adults (aged 16-21) with RPE65-LCA underwent monocular color discrimination assessment using the Trivector and Ellipse versions of three computerized tests: Cambridge Colour Test (CCT), low vision version of the Cambridge Colour Test (lvvCCT), and the Universal Colour Discrimination Test (UCDT)...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29320938/diagnosing-prosopagnosia-the-utility-of-visual-noise-in-the-cambridge-face-recognition-test
#6
Sherysse L Corrow, Andrea Albonico, Jason J S Barton
Adding visual noise to facial images has been used to increase reliance on configural processing. Whether this enhances the ability of tests to diagnose prosopagnosia is not known. We examined 15 subjects with developmental prosopagnosia, 13 subjects with acquired prosopagnosia, and 38 control subjects with the Cambridge Face Memory Test. We compared their performance on the second phase, without visual noise, and on the third phase, which adds visual noise. We analyzed the results with signal detection theory methods...
January 1, 2018: Perception
https://www.readbyqxmd.com/read/29319333/an-investigation-of-executive-functioning-in-pediatric-anxiety
#7
Yolanda E Murphy, Anna Luke, Elle Brennan, Sarah Francazio, Isabella Christopher, Christopher A Flessner
Although science's understanding (e.g., etiology, maintaining factors, etc.) of pediatric anxiety and related problems has grown substantially over recent years, several aspects to anxiety in youths remain elusive, particularly with relation to executive functioning. To this end, the current study sought to examine several facets to executive functioning (i.e., cognitive flexibility, inhibition, planning, working memory) within a transdiagnostic sample of youths exhibiting varying degrees of anxiety symptoms...
January 1, 2018: Behavior Modification
https://www.readbyqxmd.com/read/29315800/walter-harris-1647-1732-and-his-contribution-to-paediatrics
#8
Konstantinos Laios
Walter Harris (1647-1732) was a very interesting figure in paediatrics during the second half of the 17th century and first half of 18th century. He was born in Gloucester, England, and studied medicine at Bourge, France, in 1675. He continued his medical studies at Cambridge. He became physician in ordinary to Charles II (1630-1685) in 1683 and later to William III (1650-1702), accompanying him to Holland (1). This article is protected by copyright. All rights reserved.
January 8, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29315751/does-the-choice-of-the-crystal-structure-influence-the-results-of-the-periodic-dft-calculations-a-case-of-glycine-alpha-polymorph-gipaw-nmr-parameters-computations
#9
Łukasz Szeleszczuk, Dariusz Maciej Pisklak, Monika Zielińska-Pisklak
Glycine is a common amino acid with relatively complex chemistry in solid state. Although several polymorphs (α, β, δ, γ, ε) of crystalline glycine are known, for NMR spectroscopy the most important is a polymorph, which is used as a standard for calibration of spectrometer performance and therefore it is intensively studied by both experimental methods and theoretical computation. The great scientific interest in a glycine results in a large number of crystallographic information files (CIFs) deposited in Cambridge Structural Database (CSD)...
January 5, 2018: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/29314295/structure-packing-property-correlation-of-self-sorted-vs-interdigitated-assembly-in-ttf-tcnq-based-charge-transport-materials
#10
M A Niyas, Remya Ramakrishnan, Vishnu Vijay, Mahesh Hariharan
Among the various donor-acceptor (D-A) charge transfer cocrystals investigated in the past few decades, tetrathiafulvalene-tetracyanoquinodimethane (F.Q, popularly known as TTF.TCNQ) based cocrystals have fascinated materials chemists owing to its packing and exceptional properties. Here, crystallographic information files of eighteen F.Q based cocrystals were extracted from Cambridge Structural Database and classified into Class 1 (D on D and A on A segregated stacks; F.Q, F1.Q - F6.Q and F.Q1), Class 2 (-A-D-A-D-A-D- mixed stacks; F6a...
January 3, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29313343/high-throughput-computational-screening-of-the-mof-database-for-ch4-h2-separations
#11
Cigdem Altintas, Ilknur Erucar, Seda Keskin
Metal organic frameworks (MOFs) have been considered as one of the most exciting porous materials discovered in the last decade. Large surface areas, high pore volumes, tailorable pore sizes make MOFs highly promising in a variety of applications, mainly in gas separations. The number of MOFs has been increasing very rapidly and experimental identification of materials exhibiting high gas separation potential is simply impractical. High-throughput computational screening studies in which thousands of MOFs are evaluated to identify the best candidates for a target gas separation is crucial in directing experimental efforts to the most useful materials...
January 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29313131/close-contacts-involving-germanium-and-tin-in-crystal-structures-experimental-evidence-of-tetrel-bonds
#12
Patrick Scilabra, Vijith Kumar, Maurizio Ursini, Giuseppe Resnati
Modeling indicates the presence of a region of low electronic density (a "σ-hole") on group 14 elements, and this offers an explanation for the ability of these elements to act as electrophilic sites and to form attractive interactions with nucleophiles. While many papers have described theoretical investigations of interactions involving carbon and silicon, such investigations of the heavier group 14 elements are relatively scarce. The purpose of this review is to rectify, to some extent, the current lack of experimental data on interactions formed by germanium and tin with nucleophiles...
January 8, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29304263/the-prevalence-of-adverse-ocular-hemorrhagic-events-in-patients-utilizing-oral-anticoagulant-and-antiplatelet-therapy-in-routine-clinical-practice
#13
Dattanand M Sudarshana, Eleni K Konstantinou, Sruthi Arepalli, Fabiana Q Silva, Andrew P Schachat, Justis P Ehlers, Rishi P Singh
BACKGROUND AND OBJECTIVE: Previous literature assessing ocular hemorrhagic complications of anticoagulant/antiplatelet medications in routine clinical practice is limited. This study evaluates the prevalence of spontaneous ocular hemorrhagic events associated with anticoagulation/antiplatelet therapy. PATIENTS AND METHODS: A retrospective study was performed to identify patients taking anticoagulants (rivaroxaban [Xarelto; Janssen Pharmaceuticals, Beerse, Belgium], bivalirudin [Angiomax; The Medicines Company, Parsippany, NJ], lepirudin [Refludan; Bayer HealthCare Pharmaceuticals, Berlin, Germany], dabigatran [Pradaxa; Boehringer Ingelheim, Ingelheim am Rhein, Germany], and argatroban) and antiplatelet agents (clopidogrel [Plavix; Bristol-Myers Squibb, New York City, NY], prasugrel [Effient; Lilly Medical, Indianapolis, IN], and ticagrelor [Brilinta; AstraZeneca, Cambridge, UK]) who presented for an eye examination...
January 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29303497/a-chiral-diamine-practical-implications-of-a-three-stereoisomer-cocrystallization
#14
Brian S Dolinar, Kerim Samedov, Andrew G P Maloney, Robert West, Victor N Khrustalev, Ilia A Guzei
A brief comparison of seven straightforward methods for molecular crystal-volume estimation revealed that their precisions are comparable. A chiral diamine, N2,N3-bis[2,6-bis(propan-2-yl)phenyl]butane-2,3-diamine, C28H44N2, has been used to illustrate the application of the methods. Three stereoisomers of the diamine cocrystallize in the centrosymmetric space group P21/c with Z' = 1.5. The molecules occupying general positions are RR and SS, whereas that residing on an inversion center is meso. This is one of only ten examples of three stereoisomers with two asymmetric atoms cocrystallizing together reported to the Cambridge Structural Database (CSD)...
January 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29303149/assessment-and-management-of-dry-eye-disease
#15
R J Buckley
The topic of the 1984 Cambridge Ophthalmological Symposium was 'The Dry Eye'; it was chaired by my colleague and mentor Mr Peter Wright. In the 33 years that have passed since then we have learned a great deal more about this condition. This short paper sets out to review some of the more recent developments.Eye advance online publication, 5 January 2018; doi:10.1038/eye.2017.289.
January 5, 2018: Eye
https://www.readbyqxmd.com/read/29301440/advancing-the-understanding-of-progression-in-multiple-sclerosis-an-interview-with-shibeshih-belachew
#16
Shibeshih Belachew
Shibeshih Belachew speaks to Laura Dormer, Commissioning Editor: Dr Shibeshih Belachew, MD, PhD, is a Senior Medical Director for Multiple Sclerosis (MS) Disease Area in Global Product Development Medical Affairs at Roche (Basel, Switzerland). Prior to joining Roche in January 2016, he was Director of MS Franchise and Head of Medical Director's office for Biogen Region Europe and Canada. Previously at Biogen he also served as a Director in Global Neurology for the natalizumab program in Cambridge (MA, USA)...
January 5, 2018: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29301432/the-diagnosis-and-management-of-agitationedited-by-scott-l-zeller-kimberly-d-nordstrom-and-michael-p-wilson-new-york-cambridge-university-press-2017-292-pp-110-00-hardcover
#17
https://www.readbyqxmd.com/read/29296616/everolimus-for-treatment-of-tuberous-sclerosis-complex-associated-neuropsychiatric-disorders
#18
Darcy A Krueger, Anjali Sadhwani, Anna W Byars, Petrus J de Vries, David N Franz, Vicky H Whittemore, Rajna Filip-Dhima, Donna Murray, Kush Kapur, Mustafa Sahin
Objective: To evaluate if short-term treatment with everolimus was safe and could improve neurocognition and behavior in children with TSC. Methods: This was a prospective, double-blind randomized, placebo-controlled two-center phase II study. Participants diagnosed with TSC and age 6-21 years were treated with 4.5 mg/m2 per day of oral everolimus (n = 32) or matching placebo (n = 15) taken once daily for 6 months. For efficacy, a comprehensive neurocognitive and behavioral evaluation battery was performed at baseline, 3 months, and 6 months...
December 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29290155/book-review-arts-health-and-wellbeing-a-theoretical-inquiry-for-practice-arts-health-and-wellbeing-a-theoretical-inquiry-for-practice-edited-by-stickley-stickley-clift-stephen-published-by-cambridge-scholars-publishing-newcastle-2017-isbn-9781443891363
#19
https://www.readbyqxmd.com/read/29284174/bilayer-matrix-autologous-chondrocyte-implantation-without-bone-graft-for-knee-osteochondral-lesion-less-than-8%C3%A2-mm-deep
#20
Murat Bozkurt, Cetin Isik, Safa Gursoy, Mustafa Akkaya, Oktay Algin, Metin Dogan
This article investigates the clinical and radiological results of bilayer matrix autologous chondrocyte implantation (MACI) membrane technique in the treatment of shallow osteochondral defects. An analysis was made of eight patients who were operated on using the bilayer MACI (Genzyme Biosurgery, Cambridge, MA) technique (mean age: 20.2 years, mean defect size: 3.8 cm2, mean defect depth: 6.2 ± 0.9 mm, and mean follow-up time: 22.1 ± 5.3 [14-26.1] months). According to the defect, the first membrane was secured to the base of the defect with the cells facing up, and the second membrane was implanted on top of the first membrane with the cells facing down using fibrin glue...
December 28, 2017: Journal of Knee Surgery
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