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https://www.readbyqxmd.com/read/28938652/correlation-between-apparent-diffusion-coefficient-adc-and-cellularity-is-different-in-several-tumors-a-meta-analysis
#1
Alexey Surov, Hans Jonas Meyer, Andreas Wienke
The purpose of this meta-analysis was to provide clinical evidence regarding relationship between ADC and cellularity in different tumors based on large patient data. Medline library was screened for associations between ADC and cell count in different tumors up to September 2016. Only publications in English were extracted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA) was used for the research. Overall, 39 publications with 1530 patients were included into the analysis...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938638/prognostic-modeling-of-oral-cancer-by-gene-profiles-and-clinicopathological-co-variables
#2
Steven W Mes, Dennis Te Beest, Tito Poli, Silvia Rossi, Kathrin Scheckenbach, Wessel N van Wieringen, Arjen Brink, Nicoletta Bertani, Davide Lanfranco, Enrico M Silini, Paul J van Diest, Elisabeth Bloemena, C René Leemans, Mark A van de Wiel, Ruud H Brakenhoff
Accurate staging and outcome prediction is a major problem in clinical management of oral cancer patients, hampering high precision treatment and adjuvant therapy planning. Here, we have built and validated multivariable models that integrate gene signatures with clinical and pathological variables to improve staging and survival prediction of patients with oral squamous cell carcinoma (OSCC). Gene expression profiles from 249 human papillomavirus (HPV)-negative OSCCs were explored to identify a 22-gene lymph node metastasis signature (LNMsig) and a 40-gene overall survival signature (OSsig)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938536/integrating-omics-data-and-protein-interaction-networks-to-prioritize-driver-genes-in-cancer
#3
Tiejun Zhang, Di Zhang
Although numerous approaches have been proposed to discern driver from passenger, identification of driver genes remains a critical challenge in the cancer genomics field. Driver genes with low mutated frequency tend to be filtered in cancer research. In addition, the accumulation of different omics data necessitates the development of algorithmic frameworks for nominating putative driver genes. In this study, we presented a novel framework to identify driver genes through integrating multi-omics data such as somatic mutation, gene expression, and copy number alterations...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938339/reduction-techniques-for-diaphyseal-femur-fractures
#4
Philip R Wolinsky, Justin F Lucas
Achieving and maintaining reduction in patients with a diaphyseal femur fracture may be difficult; therefore, thorough preoperative planning is required. To fully prepare for successful surgical management of diaphyseal femur fractures, surgeons must consider appropriate patient positioning and necessary tools, including surgical tables, traction devices, and instruments. Principles of acceptable reduction rely on the restoration of length, alignment, and rotation. Reduction of diaphyseal femur fractures should be attained in the least invasive manner, via percutaneous reduction techniques, if possible, to preserve fracture biology and promote successful fracture healing...
September 21, 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28938323/neck-surgery-under-local-anesthesia
#5
Bojan Obradovic
The value of local anesthesia (LA) is widely recognized in oral and maxillofacial surgery. Many procedures can be performed with the use of local anesthetic alone, instilled at or near the site of surgery.The author presents a patient with neck tumor, where the tumor removal was managed under LA at outpatient clinic. Treatment and postoperative period was routine.Neck surgery under LA in outpatient environment shows a great potential in adequately selected patients.
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28938108/cervical-arthroplasty-versus-anterior-cervical-fusion-for-symptomatic-adjacent-segment-disease-after-anterior-cervical-fusion-surgery-review-of-treatment-in-41-patients
#6
Sang-Bok Lee, Kyoung-Suok Cho
OBJECTIVE: The purpose of this study is to compare the efficacy and safety of anterior cervical discectomy and fusion (ACDF) and cervical total disc replacement (CTDR) as revision surgeries for symptomatic adjacent segment degeneration (ASD) in cases with previous ACDF. PATIENTS AND METHODS: Between 2010 and 2014, 41 patients with previous cervical fusion surgery underwent ACDF or CTDR for symptomatic ASD. Twenty-two patients in the ACDF group underwent 26 ACDFs, and 19 patients in the CTDR group underwent 25 arthroplasties for symptomatic ASD...
August 4, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28938008/vca-nanobodies-target-n-wasp-to-reduce-invadopodium-formation-and-functioning
#7
Tim Hebbrecht, Isabel Van Audenhove, Olivier Zwaenepoel, Adriaan Verhelle, Jan Gettemans
Invasive cancer cells develop small actin-based protrusions called invadopodia, which perform a primordial role in metastasis and extracellular matrix remodelling. Neural Wiskott-Aldrich syndrome protein (N-WASp) is a scaffold protein which can directly bind to actin monomers and Arp2/3 and is a crucial player in the formation of an invadopodium precursor. Expression modulation has pointed to an important role for N-WASp in invadopodium formation but the role of its C-terminal VCA domain in this process remains unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28937786/prevalence-of-femoral-and-acetabular-version-abnormalities-in-patients-with-symptomatic-hip-disease-a-controlled-study-of-538-hips
#8
Till D Lerch, Inga A S Todorski, Simon D Steppacher, Florian Schmaranzer, Stefan F Werlen, Klaus A Siebenrock, Moritz Tannast
BACKGROUND: Variations in femoral and acetabular version are becoming increasingly recognized as contributing factors to the development of hip pain in patients with femoroacetabular impingement (FAI) and hip dysplasia. It is still unknown what the true prevalence of these rotational abnormalities is in this patient population. PURPOSE: To determine (1) the prevalence of femoral version abnormalities in symptomatic hips with FAI and hip dysplasia, (2) the prevalence of combined abnormalities of femoral and acetabular version in these patients, and (3) which specific hip morphologies are associated with abnormalities of femoral version...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28937577/trajectories-of-musculoskeletal-pain-from-adolescence-to-middle-age-the-role-of-early-depressive-symptoms-a-27-year-follow-up-of-the-northern-swedish-cohort
#9
Päivi Leino-Arjas, Kristiina Rajaleid, Gashaw Mekuria, Tapio Nummi, Pekka Virtanen, Anne Hammarström
Depression and musculoskeletal pain are associated, but long-term follow-up studies are rare. We aimed to examine the relationship of early depressive symptoms with developmental patterns of musculoskeletal pain from adolescence to middle age. Adolescents ending compulsory school (age 16) in Luleå, Northern Sweden, in 1981 (n = 1083) were studied and followed up in 1986, 1995, and 2008 (age 43) for musculoskeletal pain. Attrition was very low. Indicators for any and severe pain were based on pain in the neck-shoulders, low back, and the extremities...
September 19, 2017: Pain
https://www.readbyqxmd.com/read/28937485/monitoring-dynamic-morphological-changes-with-electrocardiography-gated-dynamic-4-dimensional-computed-tomography-angiography-to-predict-intraoperative-rupture-of-intracranial-aneurysms
#10
Yan Gu, Lun Xu, Chunhong Hu, Meng Luo, Hongwei Zhang, Xiguang Liu
OBJECTIVE: This study aims to evaluate dynamic morphological changes of intracranial aneurysms to predict intraoperative aneurysm rupture (IAR) during clipping. METHODS: Included in this study were 153 patients, who had ruptured and microsurgical-clipped aneurysms. All patients underwent dual-source computed tomography examination of electrocardiography-gated dynamic 4-dimensional computed tomography angiography before clipping. Original scanning data were reconstructed to produce 20 data sets of cardiac cycles with 5% time intervals...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28937464/comparison-of-clinical-outcomes-after-anterior-cervical-discectomy-and-fusion-versus-cervical-total-disk-replacement-in-patients-with-modic-2-changes-on-mri
#11
Jia Li, Di Zhang, Wenyuan Ding, Yingze Zhang, Yong Shen
STUDY DESIGN: A retrospective investigation. OBJECTIVE: The aim of this research is to compare the clinical and radiologic outcomes of patients with Modic-2 changes who underwent anterior cervical discectomy and fusion (ACDF) or cervical total disk replacement (TDR) in single level. SUMMARY OF BACKGROUND DATA: There were few studies focused on the clinical and radiologic outcomes of patients with Modic-2 changes who underwent ACDF or cervical TDR in single level...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28937463/combined-anterior-posterior-fixation-and-fusion-for-completely-dislocated-hangman-s-fracture-a-retrospective-analysis-of-11-cases
#12
Jianxi Wang, Huajiang Chen, Peng Cao, Wen Yuan, Xiaodong Wu, Gang Liu, Renhu Li, Fazhi Zang, Liangyu Shi, An Wang
STUDY DESIGN: Retrospective clinical study. PURPOSE: To evaluate the effectiveness and feasibility of combined anterior-posterior fixation and fusion for the treatment of completely dislocated hangman's fracture. SUMMARY OF BACKGROUND DATA: A completely dislocated hangman's fracture describes the complete anterior displacement of the C2 vertebral body onto the C3 body. This type of fracture is exceptionally unstable, and for which the management is challenging...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28937303/palliative-coverage-of-cranial-defect-following-failed-cranial-flap-for-advanced-squamous-cell-carcinoma-case-report
#13
Vyacheslav Makler, Jeffrey S Litt, N Scott Litofsky
INTRODUCTION: With advanced-stage head and neck cancers, patients may develop large and/or complex wounds despite multiple reconstruction attempts. Wound coverage may require novel approaches to palliate the patient. METHOD: We present the case of a 56-year-old female with advanced squamous cell carcinoma of the scalp and skull who required multiple surgical interventions. Despite our best reconstructive efforts, the patient subsequently developed scalp infection and sepsis, necessitating further debridement for source control...
September 22, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28937024/celiac-disease-related-osteopathy-among-saudi-celiac-patients-are-we-adherent-to-recommendations
#14
Mona A Fouda
BACKGROUND/AIMS: There are no reports from Saudi Arabia documenting the picture of osteopathy in celiac disease (CD) and the adherence of physicians to the guidelines and recommendations to screen for bone disease. We conducted this study to document the prevalence of CD-related osteopathy and the Saudi physicians' adherence to the screening recommendations. PATIENTS AND METHODS: We identified the biopsy proven CD cases diagnosed between 2003 and 2012. In addition to demographic data, we collected laboratory (serum calcium, phosphate, alkaline phosphatase, 25-dihydroxy vitamin D, and parathyroid hormone levels) and imaging [Dual-energy X-ray absorptiometry (DEXA)] data...
September 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28936962/-evaluation-of-the-effect-of-a-new-fixation-tape-for-tracheal-catheter-in-intensive-care-patients
#15
Limin Chen, Ruihong Liu, Biyu Shen, Lingling Wang, Zhiming Cui, Guanhua Xu
OBJECTIVE: To evaluate the effect of a new type of fixation tape for tracheal catheter in intensive care patients. METHODS: A purposive sampling study was conducted. Ninety patients experienced oral tracheal intubation for mechanical ventilation, and admitted to respiratory intensive care unit (ICU) of the Second Affiliated Hospital of Nantong University from November 2015 to February 2017 were enrolled. All the patients were randomly (random number) divided into the control group and the observation group with 45 patients in each group...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28936758/mucinous-cystic-neoplasms-of-the-pancreas-high-resolution-cross-sectional-imaging-features-with-clinico-pathologic-correlation
#16
Alejandro Garces-Descovich, Kevin Beker, Manuel Castillo-Angeles, Alexander Brook, Elena Resnick, Shweta Shinagare, Robert M Najarian, Koenraad J Mortele
PURPOSE: To describe the high-resolution cross-sectional (MDCT/MRI) features of mucinous cystic neoplasms (MCN) of the pancreas with clinico-pathologic correlation; to identify imaging predictors of high-grade dysplasia/carcinoma; and to estimate MCN growth rate. MATERIALS AND METHODS: Thirty-two women (mean age: 46; range, 25-79 years) with resected MCN who underwent preoperative MDCT (n = 20) or MRI (n = 12) examinations over a 14-year period were included...
September 21, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28936612/endotracheal-intubation-ultrasound-guided-versus-fiberscope-in-patients-with-cervical-spine-immobilization
#17
Moustafa Abdelaziz Moustafa, Emad A Arida, Ola M Zanaty, Sameh Fathy El-Tamboly
BACKGROUND: Ultrasound has growing applications in airway management during anesthesia. The aim of the present study was to evaluate the feasibility of real-time ultrasound-guided tracheal intubation in patients with cervical spine immobilization relative to fiberscope-guided tracheal intubation. PATIENTS AND METHODS: This randomized controlled study was carried out on 266 adult patients who have a rigid neck collar in place for cervical spine immobilization and were randomly allocated into two equal groups...
September 21, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28936545/open-tracheostomy-training-a-nationwide-survey-among-otolaryngology-head-and-neck-surgery-residents
#18
Limor Muallem-Kalmovich, Jacob Pitaro, Ayman Asaly, Alex Kessler, Ephraim Eviatar, Moran Shteiner, Tal Marom
The aim of this study was to examine the training methods and needs of Otolaryngology-Head and Neck Surgery (OTO-HNS) residents to independently perform open tracheostomy (OT). An anonymous 26-items questionnaire pertaining to OT teaching aspects was distributed to all 93 Israeli OTO-HNS residents during March-June 2016. Residents were categorized as 'juniors,' if they were in their post-graduate year (PGY)-1 and PGY-2; 'mid-residency' (PGY-3 and PGY-4); or 'seniors' (PGY-5 and PGY-6). Response rate was 74% (n = 69)...
September 21, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28936292/evolution-of-oral-cancer-treatment-in-an-andalusian-population-sample-rehabilitation-with-prosthetic-obturation-and-removable-partial-prosthesis
#19
Rafael Flores-Ruiz, Lizette Castellanos-Cosano, María-Angeles Serrera-Figallo, Aida Gutiérrez-Corrales, Maribel Gonzalez-Martin, Jose-Luis Gutiérrez-Pérez, Daniel Torres-Lagares
BACKGROUND: Radical surgical resection as a treatment modality for oral cancer often leads to an extensive deficit in both the maxillary and mandibular levels, where the use of a palatal obturator prosthesis (POP) or removable partial denture (RPP). The aim of this study was to evaluate the treatment with POP and RPP in patients treated for oral cancer in the Unit of Prosthetic Rehabilitation of the University Hospital Virgen del Rocío in a period of 20 years. MATERIAL AND METHODS: Retrospective descriptive study during the years 1991 and 2011 analyzing oral cancer type, characteristics, treatment and follow-up...
August 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28936056/syringocystadenoma-papilliferum-of-sweat-gland-of-caruncle-a-unique-case-report
#20
Anuradha Raj, R C Nagpal, Meena Harsh, Harsh Bahadur
Syringocystadenoma papilliferum (SP) is a rare benign hamartomatous malformation of skin which arises from apocrine or eccrine sweat glands. Skin of the head and neck is the usual site for this but rarely involves the eyelids. It is also called as a childhood tumor since it usually appears at birth or during puberty. The diagnosis is confirmed on histopathological examination after surgical excision. We are first to report a case of SP involving the caruncle in an elderly female.
April 2017: Middle East African Journal of Ophthalmology
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