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Aggression in Dementia

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https://www.readbyqxmd.com/read/29770363/the-multifaceted-clinical-presentation-of-vcp-proteinopathy-in-a-greek-family
#1
George K Papadimas, George P Paraskevas, Thomas Zambelis, Chrisostomos Karagiaouris, Mara Bourbouli, Anastasia Bougea, Maggie C Walter, Nicolas U Schumacher, Sabine Krause, Elisabeth Kapaki
VCP-proteinopathy is a multisystem neurodegenerative disorder caused by mutations in valosin containing protein. Here, we report the first Greek case of VCP-proteinopathy in a 62 year old patient with a slowly progressing muscular weakness since his mid-40s and a severe deterioration during the last year. He also manifested dementia with prominent neuropsychiatric symptoms, including aggression, apathy, palilalia and obsessions. Brain MRI revealed frontal atrophy, while muscle MRI showed diffuse muscle atrophy...
December 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/29764282/animal-assisted-therapy-in-elderly-patients-evidence-and-controversies-in-dementia-and-psychiatric-disorders-and-future-perspectives-in-other-neurological-diseases
#2
Silvio Peluso, Anna De Rosa, Natascia De Lucia, Antonella Antenora, Maddalena Illario, Marcello Esposito, Giuseppe De Michele
Animal-assisted therapy (AAT) includes a set of nonpharmacological interventions aimed at improving human health through the use of trained or untrained animals. In recent decades, AAT has been trialed for different neurological and psychiatric disorders. In patients with dementia, interaction with animals seems to have a positive influence on aggressiveness and anxiety and to ameliorate quality of life and relationship skills. In psychiatric patients, AAT seems to increase motivation and self-esteem, improve prosocial conduct, and decrease behavioral problems...
January 1, 2018: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/29755713/a-mobile-multimedia-reminiscence-therapy-application-to-reduce-behavioral-and-psychological-symptoms-in-persons-with-alzheimer-s
#3
Danish Imtiaz, Arshia Khan, Adriana Seelye
The goal of this project is to develop a novel and innovative mobile solution to address behavioral and psychological symptoms of dementia (BPSD) that occur in individuals with Alzheimer's. BPSD can include agitation, restlessness, aggression, apathy, obsessive-compulsive and repetitive behaviors, hallucinations, delusions, paranoia, and wandering. Alzheimer's currently affects 5.4 million adults in the United States and that number is projected to increase to 14 million by 2050. Almost 90% of all affected with AD experience BPSD, resulting in increased healthcare costs, heavier burden on caregivers, poor patient outcomes, early nursing home placement, long-term hospitalizations, and misuse of medications...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29755341/plasma-biomarkers-differentiate-parkinson-s-disease-from-atypical-parkinsonism-syndromes
#4
Chin-Hsien Lin, Shieh-Yueh Yang, Herng-Er Horng, Che-Chuan Yang, Jen-Jie Chieh, Hsin-Hsien Chen, Bing-Hsien Liu, Ming-Jang Chiu
Objective: Parkinson's disease (PD) has significant clinical overlaps with atypical parkinsonism syndromes (APS), which have a poorer treatment response and a more aggressive course than PD. We aimed to identify plasma biomarkers to differentiate PD from APS. Methods: Plasma samples ( n = 204) were obtained from healthy controls and from patients with PD, dementia with Lewy bodies (DLB), multiple system atrophy, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), or frontotemporal dementia (FTD) with parkinsonism (FTD-P) or without parkinsonism...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29743672/cellular-milieu-imparts-distinct-pathological-%C3%AE-synuclein-strains-in-%C3%AE-synucleinopathies
#5
Chao Peng, Ronald J Gathagan, Dustin J Covell, Coraima Medellin, Anna Stieber, John L Robinson, Bin Zhang, Rose M Pitkin, Modupe F Olufemi, Kelvin C Luk, John Q Trojanowski, Virginia M-Y Lee
In Lewy body diseases-including Parkinson's disease, without or with dementia, dementia with Lewy bodies, and Alzheimer's disease with Lewy body co-pathology 1 -α-synuclein (α-Syn) aggregates in neurons as Lewy bodies and Lewy neurites 2 . By contrast, in multiple system atrophy α-Syn accumulates mainly in oligodendrocytes as glial cytoplasmic inclusions (GCIs) 3 . Here we report that pathological α-Syn in GCIs and Lewy bodies (GCI-α-Syn and LB-α-Syn, respectively) is conformationally and biologically distinct...
May 9, 2018: Nature
https://www.readbyqxmd.com/read/29739423/isupport-an-online-training-and-support-program-for-caregivers-of-people-with-dementia-study-protocol-for-a-randomized-controlled-trial-in-india
#6
Kala M Mehta, Dolores Gallagher-Thompson, Mathew Varghese, Santosh Loganathan, Upasana Baruah, Katrin Seeher, Diana Zandi, Tarun Dua, Anne Margriet Pot
BACKGROUND: Dementia has a huge physical, psychological, social and economic impact upon caregivers, families and societies at large. There has been a growing impetus to utilize Internet interventions given the potential scalability, and presumed cost-effectiveness and accessibility. In this paper, we describe the design of a randomized controlled trial (RCT) aiming to study the impact of online self-help programs on caregivers of people with dementia in India. The experimental group will receive an interactive training and support program and the comparison group will receive an education-only e-book...
May 8, 2018: Trials
https://www.readbyqxmd.com/read/29734098/investigation-of-possible-risk-factors-for-depression-in-alzheimer-s-disease-a-systematic-review-of-the-evidence
#7
REVIEW
Natassa Steck, Claudia Cooper, Vasiliki Orgeta
BACKGROUND: Depression is common in people with Alzheimer's disease (AD), and is associated with increased risk of institutionalization and mortality. Understanding risk factors for depression in AD is key to its development and treatment. METHODS: We searched the MEDLINE, EMBASE, PsycINFO, and CINAL databases for longitudinal prospective cohort studies that evaluated risk factors for depression in people with AD. Two authors independently selected articles for inclusion and assessed quality of studies using predetermined criteria...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29723236/health-management-and-pattern-analysis-of-daily-living-activities-of-people-with-dementia-using-in-home-sensors-and-machine-learning-techniques
#8
Shirin Enshaeifar, Ahmed Zoha, Andreas Markides, Severin Skillman, Sahr Thomas Acton, Tarek Elsaleh, Masoud Hassanpour, Alireza Ahrabian, Mark Kenny, Stuart Klein, Helen Rostill, Ramin Nilforooshan, Payam Barnaghi
The number of people diagnosed with dementia is expected to rise in the coming years. Given that there is currently no definite cure for dementia and the cost of care for this condition soars dramatically, slowing the decline and maintaining independent living are important goals for supporting people with dementia. This paper discusses a study that is called Technology Integrated Health Management (TIHM). TIHM is a technology assisted monitoring system that uses Internet of Things (IoT) enabled solutions for continuous monitoring of people with dementia in their own homes...
2018: PloS One
https://www.readbyqxmd.com/read/29710716/brain-inflammation-connects-cognitive-and-non-cognitive-symptoms-in-alzheimer-s-disease
#9
M Clara Selles, Mauricio M Oliveira, Sergio T Ferreira
Alzheimer's disease (AD) is the main form of dementia in the elderly and affects greater than 47 million people worldwide. Care for AD patients poses very significant personal and economic demands on individuals and society, and the situation is expected to get even more dramatic in the coming decades unless effective treatments are found to halt the progression of the disease. Although AD is most commonly regarded as a disease of the memory, the entire brain is eventually affected by neuronal dysfunction or neurodegeneration, which brings about a host of other behavioral disturbances...
April 25, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29708208/apathy-and-functional-disability-in-behavioral-variant-frontotemporal-dementia
#10
Mônica S Yassuda, Thais B Lima da Silva, Claire M O'Connor, Shailaja Mekala, Suvarna Alladi, Valeria S Bahia, Viviane Almaral-Carvalho, Henrique C Guimaraes, Paulo Caramelli, Marcio L F Balthazar, Benito Damasceno, Sonia M D Brucki, Ricardo Nitrini, John R Hodges, Olivier Piguet, Eneida Mioshi
Background: Behavioral variant frontotemporal dementia (bvFTD) has profound consequences on patients and their families. In this multicenter study, we investigated the contribution of cognitive and neuropsychiatric factors to everyday function at different levels of overall functional impairment. Methods: In a retrospective cross-sectional study, 109 patients with bvFTD from 4 specialist frontotemporal dementia centers (Australia, England, India, and Brazil) were included...
April 2018: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29689719/the-behavioral-and-psychological-symptoms-of-dementia-in-down-syndrome-bpsd-ds-scale-comprehensive-assessment-of-psychopathology-in-down-syndrome
#11
Alain D Dekker, Silvia Sacco, Angelo Carfi, Bessy Benejam, Yannick Vermeiren, Gonny Beugelsdijk, Mieke Schippers, Lyanne Hassefras, José Eleveld, Sharina Grefelman, Roelie Fopma, Monique Bomer-Veenboer, Mariángeles Boti, G Danielle E Oosterling, Esther Scholten, Marleen Tollenaere, Laura Checkley, André Strydom, Gert Van Goethem, Graziano Onder, Rafael Blesa, Christine Zu Eulenburg, Antonia M W Coppus, Anne-Sophie Rebillat, Juan Fortea, Peter P De Deyn
People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. In a European multidisciplinary study, the novel Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) scale was developed to identify frequency and severity of behavioral changes taking account of life-long characteristic behavior. 83 behavioral items in 12 clinically defined sections were evaluated...
April 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29682241/drug-administration-adjustments-for-elderly-patients-with-dysphagia-a-case-report
#12
Patrícia de Carvalho Mastroianni, Marcela Forgerini
An elderly patient, aged 76 years, diagnosed with dysphagia, depression, hypothyroidism, Alzheimer's disease and mild cognitive deficit, was identified with sertraline and levothyroxine- drug-related problems. Medication Therapy Management (MTM) was used to adjust therapy to the patient's needs by macerating sertraline tablets and solubilizing them in 10-30 mL of orange juice. The patient was advised to take levothyroxine after fasting. Six months later, pharmaceutical follow-up identified an increase in the Mini-Mental State Exam score from 22 to 26 and a decrease in the Clinical Dementia Rating (CDR) scale score from 1...
January 2018: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29663890/methodologies-related-to-computational-models-in-view-of-developing-anti-alzheimer-drugs-an-overview
#13
Kirtee Baheti, Mayura Ajay Kale
BACKGROUND: Since last two decades, there has been more focus on the development strategies related to Anti-Alzheimer's drug research. This may be attributed to the fact that most of the Alzheimer's cases are still mostly unknown except for a few cases, where genetic differences have been identified. With the progress of the disease, the symptoms involve intellectual deterioration, memory impairment, abnormal personality and behavioural patterns, confusion, aggression, mood swings, irritability Current therapies available for this disease give only symptomatic relief and do not focus on manipulations of biololecular processes...
April 17, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29616602/correlates-of-nursing-care-burden-among-institutionalized-patients-with-dementia
#14
Meng Sun, Brian J Mainland, Tisha J Ornstein, Gwen Li Sin, Nathan Herrmann
ABSTRACTBackground:The stress associated with care of patients with dementia has led to high nursing staff turnover. This study aims to explore patient factors that are related to nursing burden. METHODS: The present study examined nursing care burden related to 55 institutionalized dementia patients using the Modified Nursing Care Assessment Scale (M-NCAS). Cognition was assessed with the Severe Impairment Battery (SIB), activities of daily living (ADLs) were measured with the Alzheimer's Disease Functional Assessment of Change Scale (ADFACS), aggression was measured with the Aggressive Behavior Scale (ABS), and the Charlson Comorbidity Index (CCI) was used to assess medical comorbidity...
April 4, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29615111/metabolic-correlates-of-reserve-and-resilience-in-mci-due-to-alzheimer-s-disease-ad
#15
Matteo Bauckneht, Andrea Chincarini, Roberta Piva, Dario Arnaldi, Nicola Girtler, Federico Massa, Matteo Pardini, Matteo Grazzini, Hulya Efeturk, Marco Pagani, Gianmario Sambuceti, Flavio Nobili, Silvia Morbelli
BACKGROUND: We explored the presence of both reserve and resilience in late-converter mild cognitive impairment due to Alzheimer's disease (MCI-AD) and in patients with slowly progressing amyloid-positive MCI by assessing the topography and extent of neurodegeneration with respect to both "aggressive" and typically progressing phenotypes and in the whole group of patients with MCI, grounding the stratification on education level. METHODS: We analyzed 94 patients with MCI-AD followed until conversion to dementia and 39 patients with MCI who had brain amyloidosis (AMY+ MCI), all with available baseline18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) results...
April 3, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29605970/withdrawal-versus-continuation-of-long-term-antipsychotic-drug-use-for-behavioural-and-psychological-symptoms-in-older-people-with-dementia
#16
REVIEW
Ellen Van Leeuwen, Mirko Petrovic, Mieke L van Driel, An Im De Sutter, Robert Vander Stichele, Tom Declercq, Thierry Christiaens
BACKGROUND: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS...
March 30, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29578357/african-american-caregivers-perspectives-on-aggressive-behaviors-in-dementia
#17
Bryan R Hansen, Nancy A Hodgson, Laura N Gitlin
Purpose Although African-American dementia caregivers report less upset and more confidence managing aggressive behaviors when compared to whites, their contextual experience remains unclear and this study explores that context. Methods Semi-structured interviews with 13 African-American family caregivers were analyzed using content analysis. Results Two themes emerged, "It's the disease…not the person" and "You got to pick your battles." "It's the disease…not the person," reframing aggressive behavior, included three sub-themes...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29571749/detecting-agitation-and-aggression-in-people-with-dementia-using-sensors-a-systematic-review
#18
REVIEW
Shehroz S Khan, Bing Ye, Babak Taati, Alex Mihailidis
Agitation and aggression are among the most challenging symptoms of dementia. Agitated persons with dementia can harm themselves, their caregivers, or other patients in a care facility. Automatic detection of agitation would be useful to alert caregivers so that appropriate interventions can be performed. The building blocks in the automatic detection of agitation and aggression are appropriate sensing platforms and generalized predictive models. In this article, we perform a systematic review of studies that use different types of sensors to detect agitation and aggression in persons with dementia...
March 20, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29557193/managing-behavioural-and-psychological-symptoms-in-community-dwelling-older-people-with-dementia-2-a-systematic-review-of-qualitative-studies
#19
Andreas Braun, Daksha P Trivedi, Angela Dickinson, Laura Hamilton, Claire Goodman, Heather Gage, Kunle Ashaye, Steve Iliffe, Jill Manthorpe
Background People living with dementia often develop distressing behavioural and psychological symptoms (BPSD) that can affect their quality of life and the capacity of family carers and staff providing support at home. This systematic review of qualitative studies considers the views and experiences of people living with dementia and care providers about these symptoms and what helps to reduce their impact. Methods The two-stage review involved (a) An initial mapping of the literature to understand the range of BPSD, and how it is operationalised by different groups, to develop a search strategy; (b) A search of electronic databases from January 2000 to March 2015, updated in October 2016...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29549870/putting-responsive-behaviours-in-place-examining-how-formal-and-informal-carers-understand-the-actions-of-people-with-dementia
#20
R V Herron, M A Wrathall
Living alongside and working with people with dementia who yell or strike out can be very demanding and sometimes harmful. It is generally understood that such actions may be a response to the social and physical environment, yet very little attention has been paid to understanding what role the environment plays in eliciting and responding to these actions across different settings. Drawing on 27 semi-structured interviews with formal and informal carers, this article examines how carers understand the actions of people with dementia in relation to their environment...
May 2018: Social Science & Medicine
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