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Aggression in Dementia

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https://www.readbyqxmd.com/read/29319920/employee-attitudes-toward-aggression-in-persons-with-dementia-readiness-for-wider-adoption-of-person-centered-frameworks
#1
Vanessa Louise Burshnic, Natalie Douglas, Robert Michael Barker
INTRODUCTION: Implementing person-centered care requires shared attitudes, beliefs, and values among all care employees. Existing research has failed to examine the attitudes of non-nursing employees. AIM: This study examined attitudes toward aggression among nursing and non-nursing employees to address gaps in existing research and assess readiness for wider adoption of person-centered frameworks. METHOD: The Management of Aggression in People with Dementia Attitude Questionnaire was used to survey attitudes of employees in Michigan-based nursing homes...
January 10, 2018: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/29318507/mid-term-prognosis-of-non-functioning-pituitary-adenomas-with-high-proliferative-potential-really-an-aggressive-variant
#2
Yoshikazu Ogawa, Hidefumi Jokura, Kuniyasu Niizuma, Teiji Tominaga
Pituitary adenomas with high proliferation rate and rapid growth are well known, but the clinical characteristics, prognosis, and treatment algorithm remain unclear. The clinical characteristics and mid-term prognosis of patients with non-functioning pituitary adenomas with high proliferative potential were retrospectively investigated. This study identified 53 patients with Ki-67 labeling index of > 3% among 845 patients with non-functioning pituitary adenoma (6.3%) initially treated by surgery. Prophylactic treatment was not applied for patients with residual tumor, but salvage treatment was performed if tumor progression was identified within the follow-up period...
January 9, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29307083/in-thai-nationals-the-apoe4-allele-affects-multiple-domains-of-neuropsychological-biobehavioral-and-social-functioning-thereby-contributing-to-alzheimer-s-disorder-while-the-apoe3-allele-protects-against-neuropsychiatric-symptoms-and-psychosocial-deficits
#3
Sookjaroen Tangwongchai, Thitiporn Supasitthumrong, Solaphat Hemrunroj, Chavit Tunvirachaisakul, Phenphichcha Chuchuen, Natnicha Houngngam, Thiti Snabboon, Ittipol Tawankanjanachot, Yuthachai Likitchareon, Kamman Phanthumchindad, Michael Maes
The apolipoprotein E epsilon 4 (ApoE4) allele is the strongest genetic risk factor for Alzheimer's disorder (AD) and is associated with semantic and episodic memory deficits. The aim of this study was to examine the associations between ApoE alleles (E2, E3, E4) and genotypes and neuropsychological tests, behavioral functions, and dementia symptoms as assessed using Consortium to Establish a Registry for Alzheimer's Disease (CERAD). This study included 60 patients with Alzheimer's disorder (AD), 60 with mild cognitive disorder (MCI), and 62 normal volunteers...
January 6, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29305363/efficacy-and-safety-of-maintenance-electroconvulsive-therapy-for-sustaining-resolution-of-severe-aggression-in-a-major-neurocognitive-disorder
#4
Melanie Isabella Selvadurai, Robyn Waxman, Omar Ghaffar, Ilan Fischler
We report a novel electroconvulsive therapy (ECT) regimen for sustaining the resolution of behavioural and psychological symptoms of dementia (BPSD) using alternating acute and maintenance ECT (M-ECT) trials. A 64-year-old man presenting with major neurocognitive disorder was admitted for acute behavioural disturbances and physical aggression. With few treatment options, the impact on patients' quality of life often supersedes cognitive symptoms and is a predictor of long-term institutionalisation. Recent studies indicate that ECT may be an effective and safe way to address BPSD...
January 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29259137/distinct-differences-in-prion-like-seeding-and-aggregation-between-tau-protein-variants-provide-mechanistic-insights-into-tauopathies
#5
Kevin H Strang, Cara L Croft, Zachary A Sorrentino, Paramita Chakrabarty, Todd E Golde, Benoit I Giasson
The accumulation of aberrantly aggregated microtubule-associated protein tau (MAPT)1 defines a spectrum of tauopathies, including Alzheimer's disease. Mutations in the MAPT gene cause frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), characterized by neuronal pathological tau inclusions in the form of neurofibrillary tangles and Pick bodies, and in some cases glial tau pathology. Increasing evidence points to the importance of prion-like seeding as a mechanism for the pathological spread in tauopathy and other neurodegenerative diseases...
December 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29234900/trace-lithium-and-mental-health
#6
REVIEW
Nobuyoshi Ishii, Takeshi Terao
Lithium therapy is generally accepted as a first-line treatment for bipolar disorder, and it is also identified as one of the best augmenting options for treatment-resistant depression. Furthermore, lithium has been investigated in association with suicide, dementia and aggressiveness. In this review, we examined articles about the effects of very small amounts of lithium in treating suicide, dementia, bipolar disorder and temperament, to assess the present state of trace lithium's effect on mental state. The results indicate that trace lithium may be effective for suicide prevention but randomized, placebo-controlled trials are required to draw a definite conclusion...
December 12, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29226326/retreg1-fam134b-a-new-player-in-human-diseases-15-years-after-the-discovery-in-cancer
#7
REVIEW
Farhadul Islam, Vinod Gopalan, Alfred King-Yin Lam
FAM134B (family with sequence similarity 134, member B) / RETREG1 and its functional roles are relatively new in human diseases. This review aimed to summarize various functions of FAM134B since our first discovery of the gene in 2001. The protein encoded by FAM134B is a reticulophagy receptor that regulates turnover of the endoplasmic reticulum (ER) by selective phagocytosis. Absence or non-functional expression of FAM134B protein impairs ER-turnover and thereby is involved in the pathogenesis of some human diseases...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29169407/the-clinical-significance-of-plasma-clusterin-and-a%C3%AE-in-the-longitudinal-follow-up-of-patients-with-alzheimer-s-disease
#8
Jung-Lung Hsu, Wei-Ju Lee, Yi-Chu Liao, Shuu-Jiun Wang, Jong-Ling Fuh
BACKGROUND: Clusterin and beta-amyloid (Aβ) are involved in the pathogenesis of Alzheimer's disease (AD). The clinical significance of plasma clusterin and Aβ in AD progression remains controversial. METHODS: We recruited 322 patients with AD and 88 controls between August 2012 and June 2013. All participants were evaluated at baseline with a clinical assessment, Mini-Mental State Examination (MMSE), and Clinical Dementia Rating (CDR) scales. Patients with AD were evaluated annually with the MMSE and Neuropsychiatric Inventory (NPI) scale during the 2-year follow-up period...
November 23, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29161971/lying-to-patients-with-dementia-attitudes-versus-behaviours-in-nurses
#9
Daniela Cantone, Francesco Attena, Sabrina Cerrone, Antonio Fabozzi, Riccardo Rossiello, Laura Spagnoli, Concetta Paola Pelullo
BACKGROUND: Using lies, in dementia care, reveals a common practice far beyond the diagnosis and prognosis, extending to the entire care process. OBJECTIVES: In this article, we report results about the attitude and the behaviour of nurses towards the use of lies to patients with dementia. RESEARCH DESIGN: An epidemiological cross-sectional study was conducted between September 2016 and February 2017 in 12 elderly residential facilities and in the geriatric, psychiatric and neurological wards of six specialised hospitals of Italy's Campania Region...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/29156941/supporting-family-dementia-caregivers-testing-the-efficacy-of-dementia-care-management-on-multifaceted-caregivers-burden
#10
I Zwingmann, W Hoffmann, B Michalowsky, A Dreier-Wolfgramm, J Hertel, D Wucherer, T Eichler, I Kilimann, F Thiel, S Teipel, J R Thyrian
OBJECTIVES: Current research suggests that dementia care management (DCM) can decrease burden and associated health impairments of caregivers. The objective of this secondary analysis is to investigate the impact of DCM on multifaceted caregivers' burden dimensions by differentiating between objective and subjective burden. METHODS: A sample of n = 317 dyads of caregivers and community-dwelling people with dementia (PwD) participated in a general practitioner-based, cluster-randomized intervention trial (Identifier:NCT01401582) with two arms and comprehensive data assessment at baseline and 12-month follow-up...
November 20, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29150965/i-thought-he-was-going-to-set-our-house-on-fire
#11
Nancy Lutwak
Recently the wife of an octogenarian suffering from dementia brought her husband to the emergency department stating, "I can't take care of him anymore. He is becoming more aggressive. I thought he was going to set our house on fire last night". She recounted finding her husband in the kitchen at the range turning the dials. This article is protected by copyright. All rights reserved.
November 18, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29146222/nursing-staff-distress-associated-with-neuropsychiatric-symptoms-in-young-onset-dementia-and-late-onset-dementia
#12
Jeannette C L van Duinen-van den IJssel, Ans J M J Mulders, Martin Smalbrugge, Sandra A Zwijsen, Britt Appelhof, Syste U Zuidema, Marjolein E de Vugt, Frans R J Verhey, Christian Bakker, Raymond T C M Koopmans
OBJECTIVE: The aims of this study were (1) to investigate the relationship between different neuropsychiatric symptoms (NPS) and the level of distress experienced by nurses caring for residents with young-onset dementia (YOD) and (2) to compare these findings with those for nurses caring for residents with late-onset dementia (LOD). DESIGN/SETTING: This is a retrospective study conducted in Dutch long-term care facilities. Data were used from the Behavior and Evolution of Young-ONset Dementia studies (BEYOND) Parts I and II and the WAAL Behavior in Dementia-II (Waalbed-II) study...
November 14, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29137700/limitation-of-therapeutic-effort-in-patients-hospitalised-in-departments-of-internal-medicine
#13
R García Caballero, B Herreros, D Real de Asúa, S Gámez, G Vega, L García Olmos
INTRODUCTION: There is little information on the limitation of therapeutic effort (LTE) in patients admitted to hospital internal medicine units. OBJECTIVES: To describe the indicated LTE regimens in the departments of internal medicine and the characteristics of the patients who undergo them. PATIENTS AND METHODS: An observational, descriptive retrospective study was conducted on 4 hospitals of the Community of Madrid. The study collected demographic and comorbidity data and the LTE orders prescribed for all patients who died during a period of 6 months...
November 11, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/29131309/deaths-from-resident-to-resident-aggression-in-australian-nursing-homes
#14
Briony Murphy, Lyndal Bugeja, Jennifer Pilgrim, Joseph E Ibrahim
OBJECTIVES: To describe the frequency and nature of deaths from resident-to-resident aggression (RRA) in nursing homes in Australia. DESIGN: National population-based retrospective cohort study. SETTING: Accredited nursing homes in Australia. PARTICIPANTS: Residents whose deaths resulted from RRA and were reported to the coroner between July 1, 2000, and December 31, 2013. MEASUREMENTS: Cases were identified using the National Coronial Information System, and data on individual, interpersonal, organizational, and societal factors were collected through review of the paper-based coroners' files...
November 13, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29125945/periodic-eeg-patterns-in-sporadic-creutzfeld-jakob-disease-can-be-benzodiazepine-responsive-and-be-difficult-to-distinguish-from-non-convulsive-status-epilepticus
#15
Justus Marquetand, Susanne Knake, Adam Strzelczyk, Bernhard J Steinhoff, Holger Lerche, Matthis Synofzik, Niels K Focke
PURPOSE: Periodic discharges in EEG and a history of rapidly progressive dementia are known to be associated with sporadic Creutzfeld-Jakob Disease (sCJD). Doubts regarding this rare but fatal diagnosis can arise, when episodic symptoms (seizures, psychiatric features, speech disturbances) are present and the EEG shows epileptiform discharges within this periodicity. This scenario may indicate non-convulsive status epilepticus (NCSE), which is - in contrast to sCJD - a treatable and frequent condition...
December 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29124114/impact-of-programs-to-reduce-antipsychotic-and-anticholinergic-use-in-nursing-homes
#16
Ryan M Carnahan, Grant D Brown, Elena M Letuchy, Linda M Rubenstein, Brian M Gryzlak, Marianne Smith, Jeffrey C Reist, Michael W Kelly, Susan K Schultz, Michelle T Weckmann, Elizabeth A Chrischilles
Introduction: Antipsychotics are used for managing behavioral and psychological symptoms of dementia (BPSD) but have risks. Anticholinergics can worsen outcomes in dementia. The Improving Antipsychotic Appropriateness in Dementia Patients educational program (IA-ADAPT) and Centers for Medicare and Medicaid Services Partnership to Improve Dementia Care (CMS Partnership) promote improved care for BPSD. The purpose of this study was to evaluate the impact of these programs on medication use and BPSD among nursing home residents...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29109001/physician-decision-making-in-the-setting-of-advanced-illness-an-examination-of-patient-disposition-and-physician-religiousness
#17
Benjamin W Frush, Simon G Brauer, John D Yoon, Farr A Curlin
CONTEXT: Little is known about patient and physician factors that affect decisions to pursue more or less aggressive treatment courses for patients with advanced illness. OBJECTIVES: This study sought to determine how patient age, patient disposition, and physician religiousness affect physician recommendations in the context of advanced illness. METHODS: A survey was mailed to a stratified random sample of US physicians, which included three vignettes depicting advanced illness scenarios: 1) cancer, 2) heart failure, and 3) dementia with acute infection...
November 3, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29107460/electroconvulsive-therapy-for-agitation-and-aggression-in-dementia-a-systematic-review
#18
Julia F van den Berg, Henk C Kruithof, Rob M Kok, Esmée Verwijk, Harm-Pieter Spaans
OBJECTIVES: Many patients with dementia develop agitation or aggression in the course of their disease. In some severe cases, behavioral, environmental, and pharmacological interventions are not sufficient to alleviate these potentially life-threatening symptoms. It has been suggested that in those cases, electroconvulsive therapy (ECT) could be an option. This review summarizes the scientific literature on ECT for agitation and aggression in dementia. METHODS: We performed a systematic review in accordance with PRISMA guidelines...
September 25, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29035934/dextrometorphan-paroxetine-but-not-dronabinol-effective-for-treatment-resistant-aggression-and-agitation-in-an-elderly-patient-with-lewy-body-dementia
#19
Robert Wilhelm, Björn Ahl, Ion-George Anghelescu
No abstract text is available yet for this article.
October 13, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28988552/change-in-psychotropic-drug-use-in-norwegian-nursing-homes-between-2004-and-2011
#20
G Selbæk, S I M Janus, S Bergh, K Engedal, S Ruths, A S Helvik, J Šaltyte Benth, S U Zuidema
BACKGROUND: We aimed to assess whether there were any changes in the use of psychotropic drugs in Norwegian nursing homes between 2004 and 2011. Also, we investigated whether the predictors of use of specific psychotropic drug groups have changed. METHODS: We conducted a secondary analysis of two cohort studies of two Norwegian nursing home samples (2004/05 and 2010/11). Multivariate models were applied. RESULTS: We found a significant decrease in the prescription of antipsychotic drugs between 2004 and 2011 (0...
October 9, 2017: International Psychogeriatrics
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