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Aggression in Dementia

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https://www.readbyqxmd.com/read/29146222/nursing-staff-distress-associated-with-neuropsychiatric-symptoms-in-young-onset-dementia-and-late-onset-dementia
#1
Jeannette C L van Duinen-van den IJssel, Ans J M J Mulders, Martin Smalbrugge, Sandra A Zwijsen, Britt Appelhof, Syste U Zuidema, Marjolein E de Vugt, Frans R J Verhey, Christian Bakker, Raymond T C M Koopmans
OBJECTIVE: The aims of this study were (1) to investigate the relationship between different neuropsychiatric symptoms (NPS) and the level of distress experienced by nurses caring for residents with young-onset dementia (YOD) and (2) to compare these findings with those for nurses caring for residents with late-onset dementia (LOD). DESIGN/SETTING: This is a retrospective study conducted in Dutch long-term care facilities. Data were used from the Behavior and Evolution of Young-ONset Dementia studies (BEYOND) Parts I and II and the WAAL Behavior in Dementia-II (Waalbed-II) study...
November 14, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29137700/limitation-of-therapeutic-effort-in-patients-hospitalised-in-departments-of-internal-medicine
#2
R García Caballero, B Herreros, D Real de Asúa, S Gámez, G Vega, L García Olmos
INTRODUCTION: There is little information on the limitation of therapeutic effort (LTE) in patients admitted to hospital internal medicine units. OBJECTIVES: To describe the indicated LTE regimens in the departments of internal medicine and the characteristics of the patients who undergo them. PATIENTS AND METHODS: An observational, descriptive retrospective study was conducted on 4 hospitals of the Community of Madrid. The study collected demographic and comorbidity data and the LTE orders prescribed for all patients who died during a period of 6 months...
November 11, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/29131309/deaths-from-resident-to-resident-aggression-in-australian-nursing-homes
#3
Briony Murphy, Lyndal Bugeja, Jennifer Pilgrim, Joseph E Ibrahim
OBJECTIVES: To describe the frequency and nature of deaths from resident-to-resident aggression (RRA) in nursing homes in Australia. DESIGN: National population-based retrospective cohort study. SETTING: Accredited nursing homes in Australia. PARTICIPANTS: Residents whose deaths resulted from RRA and were reported to the coroner between July 1, 2000, and December 31, 2013. MEASUREMENTS: Cases were identified using the National Coronial Information System, and data on individual, interpersonal, organizational, and societal factors were collected through review of the paper-based coroners' files...
November 13, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29125945/periodic-eeg-patterns-in-sporadic-creutzfeld-jakob-disease-can-be-benzodiazepine-responsive-and-be-difficult-to-distinguish-from-non-convulsive-status-epilepticus
#4
Justus Marquetand, Susanne Knake, Adam Strzelczyk, Bernhard J Steinhoff, Holger Lerche, Matthis Synofzik, Niels K Focke
PURPOSE: Periodic discharges in EEG and a history of rapidly progressive dementia are known to be associated with sporadic Creutzfeld-Jakob Disease (sCJD). Doubts regarding this rare but fatal diagnosis can arise, when episodic symptoms (seizures, psychiatric features, speech disturbances) are present and the EEG shows epileptiform discharges within this periodicity. This scenario may indicate non-convulsive status epilepticus (NCSE), which is - in contrast to sCJD - a treatable and frequent condition...
November 4, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29124114/impact-of-programs-to-reduce-antipsychotic-and-anticholinergic-use-in-nursing-homes
#5
Ryan M Carnahan, Grant D Brown, Elena M Letuchy, Linda M Rubenstein, Brian M Gryzlak, Marianne Smith, Jeffrey C Reist, Michael W Kelly, Susan K Schultz, Michelle T Weckmann, Elizabeth A Chrischilles
Introduction: Antipsychotics are used for managing behavioral and psychological symptoms of dementia (BPSD) but have risks. Anticholinergics can worsen outcomes in dementia. The Improving Antipsychotic Appropriateness in Dementia Patients educational program (IA-ADAPT) and Centers for Medicare and Medicaid Services Partnership to Improve Dementia Care (CMS Partnership) promote improved care for BPSD. The purpose of this study was to evaluate the impact of these programs on medication use and BPSD among nursing home residents...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29109001/physician-decision-making-in-the-setting-of-advanced-illness-an-examination-of-patient-disposition-and-physician-religiousness
#6
Benjamin W Frush, Simon G Brauer, John D Yoon, Farr A Curlin
CONTEXT: Little is known about patient and physician factors that affect decisions to pursue more or less aggressive treatment courses for patients with advanced illness. OBJECTIVES: This study sought to determine how patient age, patient disposition, and physician religiousness affect physician recommendations in the context of advanced illness. METHODS: A survey was mailed to a stratified random sample of US physicians, which included three vignettes depicting advanced illness scenarios: 1) cancer, 2) heart failure, and 3) dementia with acute infection...
November 3, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29107460/electroconvulsive-therapy-for-agitation-and-aggression-in-dementia-a-systematic-review
#7
Julia F van den Berg, Henk C Kruithof, Rob M Kok, Esmée Verwijk, Harm-Pieter Spaans
OBJECTIVES: Many patients with dementia develop agitation or aggression in the course of their disease. In some severe cases, behavioral, environmental, and pharmacological interventions are not sufficient to alleviate these potentially life-threatening symptoms. It has been suggested that in those cases, electroconvulsive therapy (ECT) could be an option. This review summarizes the scientific literature on ECT for agitation and aggression in dementia. METHODS: We performed a systematic review in accordance with PRISMA guidelines...
September 25, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29035934/dextrometorphan-paroxetine-but-not-dronabinol-effective-for-treatment-resistant-aggression-and-agitation-in-an-elderly-patient-with-lewy-body-dementia
#8
Robert Wilhelm, Björn Ahl, Ion-George Anghelescu
No abstract text is available yet for this article.
October 13, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28988552/change-in-psychotropic-drug-use-in-norwegian-nursing-homes-between-2004-and-2011
#9
G Selbæk, S I M Janus, S Bergh, K Engedal, S Ruths, A S Helvik, J Šaltyte Benth, S U Zuidema
BACKGROUND: We aimed to assess whether there were any changes in the use of psychotropic drugs in Norwegian nursing homes between 2004 and 2011. Also, we investigated whether the predictors of use of specific psychotropic drug groups have changed. METHODS: We conducted a secondary analysis of two cohort studies of two Norwegian nursing home samples (2004/05 and 2010/11). Multivariate models were applied. RESULTS: We found a significant decrease in the prescription of antipsychotic drugs between 2004 and 2011 (0...
October 9, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28985387/neuropsychiatric-symptoms-and-psychotropic-drug-use-in-patients-with-dementia-in-general-practices
#10
Petra Borsje, Peter L B J Lucassen, Roland B Wetzels, Anne Margriet Pot, Raymond T C M Koopmans
Background: Neuropsychiatric symptoms (NPS) frequently occur in community-dwelling patients with dementia and they are also frequently prescribed psychotropic drugs. The prescription of psychotropic drugs has been found to be associated with the level of NPS. Data on NPS in patients with dementia in general practices are scarce. Objectives: The aim of this study was to assess the prevalence rates of NPS and psychotropic drug use (PDU) in patients with dementia in general practices...
July 14, 2017: Family Practice
https://www.readbyqxmd.com/read/28969570/new-perspectives-of-alzheimer-disease-diagnosis-the-most-popular-and-future-methods
#11
Katarzyna Pietrzak, Kamila Czarnecka, Elżbieta M Ikiciuk-Olasik, Paweł Szymański
As lifespan tendency is increasing, age-related diseases are becoming a burden to the society and health care system. Mostly incurable, constitute a subject of researchers' work. In this review the insight into the problem of Alzheimer Disease (AD) diagnostics will be given. The unquestionable diagnosis is possible only during a post-mortem examination. AD is known as one of the forms of dementia and its differentiation from mild cognitive impairments has to be improved. Despite a great diagnostic progress during last decades, medicine still needs more accurate tools for an early detection of this incurable disease...
October 2, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28969014/do-cancer-patients-with-dementia-receive-less-aggressive-treatment-in-end-of-life-care-a-nationwide-population-based-cohort-study
#12
Huei-Kai Huang, Jyh-Gang Hsieh, Chia-Jung Hsieh, Ying-Wei Wang
Dementia is a progressive, incurable disease that can deprive patients of the ability to make decisions. This study determines whether dementia influences the medical care that a cancer patient receives at the end of life. We conducted a nationwide population-based cohort study on patients aged ≥20 with newly diagnosed cancer during 2000-2012. After matching to reduce confounders, there were 7,111 patients with and 28,444 without dementia. The adjusted odd ratios (OR) for medical interventions, including intensive care, palliative care, invasive procedures, and advanced diagnostic testing, were calculated for the final month and three months of life by a multiple logistic regression model...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28965527/psychometrics-of-the-aan-caregiver-driving-safety-questionnaire-and-contributors-to-caregiver-concern-about-driving-safety-in-older-adults
#13
Janessa O Carvalho, Beth Springate, Rachel A Bernier, Jennifer Davis
BACKGROUND: The American Academy of Neurology (AAN) updated their practice parameters in the evaluation of driving risk in dementia and developed a Caregiver Driving Safety Questionnaire, detailed in their original manuscript (Iverson Gronseth, Reger, Classen, Dubinsky, & Rizzo, 2010). They described four factors associated with decreased driving ability in dementia patients: history of crashes or citations, informant-reported concerns, reduced mileage, and aggressive driving. METHOD: An informant-reported AAN Caregiver Driving Safety Questionnaire was designed with these elements, and the current study was the first to explore the factor structure of this questionnaire...
October 2, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28940504/the-association-between-cognitive-fluctuations-and-activities-of-daily-living-and-quality-of-life-among-institutionalized-patients-with-dementia
#14
Meng Sun, Brian J Mainland, Tisha J Ornstein, Sasha Mallya, Alexandra J Fiocco, Gwen Li Sin, Kenneth I Shulman, Nathan Herrmann
OBJECTIVE: Cognitive fluctuations (CFs) occur commonly in dementia of all types. While it is generally accepted that CFs can affect the clinical rating of dementia severity and neuropsychological performance, little is known about their impact on patients' activities of daily living (ADLs) and quality of life (QOL). Our study aims to explore the impact of CFs on ADLs and QOL among institutionalized patients with dementia. METHODS: The present study examined the nature and frequency of CFs in 55 institutionalized dementia patients...
September 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28939585/mediating-effect-of-postsurgical-chemotherapy-on-presence-of-dementia-and-survival-among-patients-65-and-older-with-stage-iii-colon-cancer
#15
Yingjia Chen, Rosemary D Cress, Susan L Stewart, Thomas J Semrad, Danielle Harvey, Daniel J Tencredi, Laurel Beckett
Introduction: Both colon cancer and dementia are prevalent among the elderly and have a high risk of cooccurrence. Previous studies found that patients with dementia were treated less aggressively. In this study, we hypothesized that presence of preexisting dementia was associated with worse survival for stage III colon cancer patients, and that postoperative chemotherapy was on the causal pathway.Methods: We defined preexisting dementia in Surveillance Epidemiology and End Results Medicare data through either a formal diagnosis or a prescription for dementia drugs or both before the diagnosis of cancer...
September 22, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28931452/factors-associated-with-appropriate-psychotropic-drug-prescription-in-nursing-home-patients-with-severe-dementia
#16
Klaas van der Spek, Raymond Tcm Koopmans, Martin Smalbrugge, Marjorie Hjmg Nelissen-Vrancken, Roland B Wetzels, Claudia Hw Smeets, Steven Teerenstra, Sytse U Zuidema, Debby L Gerritsen
BACKGROUND: We studied the patient and non-patients factors of inappropriate psychotropic drug (PD) prescription for neuropsychiatric symptoms (NPS) in nursing home patients with severe dementia. METHODS: In a cross-sectional study, the appropriateness of prescriptions was explored using the Appropriate Psychotropic drug use In Dementia (APID) index sum score. This index assesses information from medical records on indication, evaluation, dosage, drug-drug interactions, drug-disease interactions, duplications, and therapy duration...
September 21, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28928962/current-concepts-and-controversies-in-the-pathogenesis-of-parkinson-s-disease-dementia-and-dementia-with-lewy-bodies
#17
REVIEW
Rimona S Weil, Tammaryn L Lashley, Jose Bras, Anette E Schrag, Jonathan M Schott
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are relentlessly progressive neurodegenerative disorders that are likely to represent two ends of a disease spectrum. It is well established that both are characterised pathologically by widespread cortical Lewy body deposition. However, until recently, the pathophysiological mechanisms leading to neuronal damage were not known. It was also not understood why some cells are particularly vulnerable in PDD/DLB, nor why some individuals show more aggressive and rapid dementia than others...
2017: F1000Research
https://www.readbyqxmd.com/read/28904449/james-wenceslaus-papez-his-circuit-and-emotion
#18
Kalyan B Bhattacharyya
James Papez worked on the anatomical substrates of emotion and described a circuit, mainly composed of the hippocampus, thalamus and cingulum, and published his observations in 1937. However, such an idea existed before him, as evidenced by the rudimentary indications from Paul Broca, and Paul MacLean added some other structures like, septum, amygdala, and hypothalamus in its ambit and called it the limbic system. Paul Ivan Yakovlev, proposed a circuit which also referred to orbitofrontal, insular, anterior temporal lobe, and other nuclei of thalamus...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28883859/neuropsychiatric-symptoms-and-faster-progression-of-cognitive-impairments-as-predictors-of-risk-of-conversion-of-mild-cognitive-impairment-to-dementia
#19
Mariola Bidzan, Leszek Bidzan, Ilona Bidzan-Bluma
INTRODUCTION: The aim of this research, based on 7 years of observations, was to assess the relationship between the dynamics of changes in the realm of cognitive functions in the early stages of observations and the presence of neuropsychiatric symptoms as well as further progression of cognitive function impairments in people diagnosed with mild cognitive impairment (MCI). MATERIAL AND METHODS: One hundred and ninety three individuals were included in the study, all of whom referred themselves to the Mental Health Clinic and were diagnosed with MCI based on the criteria of the Working Group on MCI...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28882156/comparative-safety-and-efficacy-of-pharmacological-and-non-pharmacological-interventions-for-the-behavioral-and-psychological-symptoms-of-dementia-protocol-for-a-systematic-review-and-network-meta-analysis
#20
Jennifer Watt, Zahra Goodarzi, Andrea C Tricco, Areti-Angeliki Veroniki, Sharon E Straus
BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in patients with dementia. Both pharmacological and non-pharmacological strategies are commonly used to treat these symptoms, but their comparative safety and efficacy is unknown. METHODS: We will conduct a systematic review of the published and unpublished literature to retrieve all articles pertaining to outcomes of safety and efficacy associated with pharmacological and non-pharmacological treatments of BPSD for patients living in the community and institutionalized care settings...
September 7, 2017: Systematic Reviews
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