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Dementia-related behaviors

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https://www.readbyqxmd.com/read/29771729/self-regulation-and-executive-functioning-as-related-to-survival-in-motor-neuron-disease-preliminary-findings
#1
Natasha E Garcia-Willingham, Abbey R Roach, Edward J Kasarskis, Suzanne C Segerstrom
OBJECTIVE: Disease progression varies widely among patients with motor neuron disease (MND). Patients with MND and coexisting dementia have shorter survival. However, implications of mild cognitive and behavioral difficulties are unclear. The present study examined the relative contribution of executive functioning and self-regulation difficulties on survival over a 6-year period among patients with MND, who scored largely within normal limits on cognitive and behavioral indices. METHODS: Patients with MND (N=37, age=59...
May 16, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29769783/trichotillomania-ranging-from-ritual-to-illness-and-as-a-rare-clinical-manifestation-of-frontotemporal-dementia-review-of-literature-and-case-report
#2
Thomas Gregor Issac, Ashay Vivek Telang, Sadanandavalli Retnaswami Chandra
Frontotemporal dementia (FTD) is the most common form of dementia in the younger age group and often exists with comorbid obsessions and compulsions in up to 80% of the patients. Trichotillomania or compulsive "hair-pulling" disorder is a rare manifestation of FTD and is a poorly evaluated symptom in this condition. The release of "grooming functions" due to frontal disinhibition is often attributed to the evolutionary perspective; however, recent findings also implicate the role of neurotransmitter dysfunction...
March 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29740312/emotion-detection-deficits-and-decreased-empathy-in-patients-with-alzheimer-s-disease-and-parkinson-s-disease-affect-caregiver-mood-and-burden
#3
Maria Martinez, Namita Multani, Cassandra J Anor, Karen Misquitta, David F Tang-Wai, Ron Keren, Susan Fox, Anthony E Lang, Connie Marras, Maria C Tartaglia
Background : Changes in social cognition occur in patients with Alzheimer's disease (AD) and Parkinson's disease (PD) and can be caused by several factors, including emotion recognition deficits and neuropsychiatric symptoms (NPS). The aims of this study were to investigate: (1) group differences on emotion detection between patients diagnosed with AD or PD and their respective caregivers; (2) the association of emotion detection with empathetic ability and NPS in individuals with AD or PD; (3) caregivers' depression and perceived burden in relation to patients' ability to detect emotions, empathize with others, presence of NPS; and (4) caregiver's awareness of emotion detection deficits in patients with AD or Parkinson...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29738850/intermittent-streptozotocin-administration-induces-behavioral-and-pathological-features-relevant-to-alzheimer-s-disease-and-vascular-dementia
#4
Andrew S Murtishaw, Chelcie F Heaney, Monica M Bolton, Krystal Courtney D Belmonte, Michael A Langhardt, Jefferson W Kinney
RATIONALE: Diabetes mellitus (DM) is a major risk factor for Alzheimer's disease and vascular dementia. Few animal models exist that focus on the metabolic contributions to dementia onset and progression. Thus, there is strong scientific rationale to explore the effects of streptozotocin (STZ), a diabetogenic compound, on vascular and inflammatory changes within the brain. OBJECTIVE AND METHODS: The present study was designed to evaluate the effect of staggered, low-dose administration of STZ on behavioral and cognitive deficits, neuroinflammation, tau pathology, and histopathological alterations related to dementia...
May 5, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29731390/psychological-factors-related-to-nurses-intentions-to-initiate-an-antipsychotic-or-psychosocial-intervention-with-nursing-home-residents
#5
Brian M Ludwin, Suzanne Meeks
This study examined the validity of a psychological model for understanding nursing home providers' treatment choices when managing challenging dementia-related behaviors. Ninety-nine nurses from 26 long-term care facilities responded to a case study with their intentions to initiate an antipsychotic or psychosocial intervention and completed self-report measures of their attitudes, descriptive norms, self-efficacy, and outcome expectancies. The multi-level modeling results demonstrated that nurses with more positive outcome expectancies for the effect of an antipsychotic on resident behavior, and those with more positive attitudes towards antipsychotics, had greater intentions to initiate an antipsychotic...
May 3, 2018: Geriatric Nursing
https://www.readbyqxmd.com/read/29728749/the-role-of-18f-fp-cit-pet-in-differentiation-of-progressive-supranuclear-palsy-and-frontotemporal-dementia-in-the-early-stage
#6
Han Soo Yoo, Seok Jong Chung, Soo-Jong Kim, Jung Su Oh, Jae Seung Kim, Byoung Seok Ye, Young Ho Sohn, Phil Hyu Lee
PURPOSE: The purpose of this study was to evaluate whether the pattern of striatal dopamine transporter (DAT) availability could differentiate between progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) in the first few years of the disease. METHODS: We enrolled patients who had Parkinsonism and frontal dysfunction and/or language deficit, visited the clinic within 2 years of the onset of symptoms, and had been followed-up for longer than 5 years; thus resulting in 26 patients with PSP and 24 patients with FTD...
May 4, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29723128/factors-influencing-family-surrogates-intention-with-regard-to-do-not-resuscitate-directive-for-patients-with-dementia
#7
Yu-Chiung Fang, Ming-Chyi Pai, Liang-Chao Wang, Ya-Ping Yang, Chung-Yi Li, Feng-Ping Lee, Jing-Jy Wang
OBJECTIVE: To investigate the prevalence of family surrogates' do-not-resuscitate (DNR) intention for patients with dementia (PwD), and factors influencing family surrogates' decisions. METHODS: This is a descriptive and cross-sectional study. Patients with dementia and their family surrogates from Dementia Outpatient Clinic of a teaching hospital in southern Taiwan were included. Data were collected using chart review and questionnaire survey. Influential factors were analyzed using multiple logistic regression...
April 10, 2018: Clinical Gerontologist
https://www.readbyqxmd.com/read/29719498/anxiety-and-10-year-risk-of-incident-dementia-an-association-shaped-by-depressive-symptoms-results-of-the-prospective-three-city-study
#8
Marion Mortamais, Meriem Abdennour, Valérie Bergua, Christophe Tzourio, Claudine Berr, Audrey Gabelle, Tasnime N Akbaraly
Background: Anxiety is common in patients with cognitive impairment and dementia. However, whether anxiety is a risk factor for dementia is still not known. We aimed to examine the association between trait anxiety at baseline and the 10-year risk of incident dementia to determine to which extent depressive symptoms influence this relationship in the general population. Methods: Data came from 5,234 community-dwelling participants from the Three-City prospective cohort study, aged 65 years at baseline and followed over 10 years...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29716885/an-assistive-technology-system-that-provides-personalized-dressing-support-for-people-living-with-dementia-capability-study
#9
Winslow Burleson, Cecil Lozano, Vijay Ravishankar, Jisoo Lee, Diane Mahoney
BACKGROUND: Individuals living with advancing stages of dementia (persons with dementia, PWDs) or other cognitive disorders do not have the luxury of remembering how to perform basic day-to-day activities, which in turn makes them increasingly dependent on the assistance of caregivers. Dressing is one of the most common and stressful activities provided by caregivers because of its complexity and privacy challenges posed during the process. OBJECTIVE: In preparation for in-home trials with PWDs, the aim of this study was to develop and evaluate a prototype intelligent system, the DRESS prototype, to assess its ability to provide automated assistance with dressing that can afford independence and privacy to individual PWDs and potentially provide additional freedom to their caregivers (family members and professionals)...
May 1, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29710704/assessment-of-the-mid-life-demographic-and-lifestyle-risk-factors-of-dementia-using-data-from-the-framingham-heart-study-offspring-cohort
#10
Jinlei Li, Matthew Ogrodnik, Vijaya B Kolachalama, Honghuang Lin, Rhoda Au
BACKGROUND: Dementia is the leading cause of dependence and disability in the elderly population worldwide. However, currently there is no effective medication for dementia treatment. Therefore, identifying life-related risk factors including some that are modifiable may provide important strategies for reducing risk of dementia. OBJECTIVE: This study aims to highlight associations between easily obtainable life risk factors in mid-life and dementia in later adulthood...
April 27, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29704213/%C3%A9-synuclein-strains-and-seeding-in-parkinson-s-disease-incidental-lewy-body-disease-dementia-with-lewy-bodies-and-multiple-system-atrophy-similarities-and-differences
#11
REVIEW
W Peelaerts, L Bousset, V Baekelandt, R Melki
Several age-related neurodegenerative disorders are characterized by the deposition of aberrantly folded endogenous proteins. These proteins have prion-like propagation and amplification properties but so far appear nontransmissible between individuals. Because of the features they share with the prion protein, PrP, the characteristics of pathogenic protein aggregates in several progressive brain disorders, including different types of Lewy body diseases (LBDs), such as Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB), have been actively investigated...
April 27, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29695193/efficacy-and-safety-of-atypical-antipsychotics-for-behavioral-and-psychological-symptoms-of-dementia-among-community-dwelling-adults
#12
Katy E Trinkley, Allison M Sturm, Kyle Porter, Milap C Nahata
INTRODUCTION: Options for the treatment of the behavioral and psychological symptoms of dementia (BPSD) are limited. Atypical antipsychotics are often used but have questionable efficacy and are generally considered high risk. Therefore, the objective of this study is to evaluate the efficacy and safety of using any atypical antipsychotic for the treatment of BPSD among outpatients. METHODS: Retrospective observational study of an academic outpatient memory disorders clinic...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29689719/the-behavioral-and-psychological-symptoms-of-dementia-in-down-syndrome-bpsd-ds-scale-comprehensive-assessment-of-psychopathology-in-down-syndrome
#13
Alain D Dekker, Silvia Sacco, Angelo Carfi, Bessy Benejam, Yannick Vermeiren, Gonny Beugelsdijk, Mieke Schippers, Lyanne Hassefras, José Eleveld, Sharina Grefelman, Roelie Fopma, Monique Bomer-Veenboer, Mariángeles Boti, G Danielle E Oosterling, Esther Scholten, Marleen Tollenaere, Laura Checkley, André Strydom, Gert Van Goethem, Graziano Onder, Rafael Blesa, Christine Zu Eulenburg, Antonia M W Coppus, Anne-Sophie Rebillat, Juan Fortea, Peter P De Deyn
People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. In a European multidisciplinary study, the novel Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) scale was developed to identify frequency and severity of behavioral changes taking account of life-long characteristic behavior. 83 behavioral items in 12 clinically defined sections were evaluated...
April 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29683852/reversing-interferon-alpha-neurotoxicity-in-a-hiv-associated-neurocognitive-disorders-mouse-model
#14
Rajeth Koneru, Heather Bimonte-Nelson, Vincent Ciavatta, Woldeab Haile, Kate Elmore, Jennifer Ward, Leonard Maroun, William R Tyor
OBJECTIVE: Increased brain interferon-alpha (IFNα) is associated with neurodegenerative disorders, including HIV-associated neurocognitive disorders (HAND). HAND occurs in approximately 50% of individuals with HIV despite combined antiretroviral therapy (cART). Therefore, adjunctive therapies must be developed that prevent progression of mild forms of HAND to HIV-associated dementia. Increased IFNα in the CNS has been associated with HAND in patients and in a HAND mouse model. DESIGN AND METHODS: B18R binds IFNα and ameliorates HAND mouse brain histopathology (HIV encephalitis)...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29672813/-topics-on-which-relatives-of-persons-with-dementia-seek-counseling-over-telephone-or-email-current-results-of-a-nationwide-counseling-service-of-the-german-alzheimer-society
#15
Anna Pendergrass, Saskia Weiß, Elmar Gräßel
BACKGROUND: Since 15 years, the Alzheimer 's Telephone of the German Alzheimer Society (Deutsche Alzheimer Gesellschaft e.V.; DAlzG), a nationwide psychosocial counseling service, has been offering support for people with dementia (PwD) and their families. The aim of this study was to evaluate: a) why informal PwD caregivers seek telephone counseling, b) whether these telephone calls are one-time counseling or long-term support, and c) whether the telephone inquiries differ from the email-based inquiries with regard to the addressed issues...
April 19, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29671901/using-dolls-for-therapeutic-purposes-a-study-on-nursing-home-residents-with-severe-dementia
#16
A Cantarella, E Borella, S Faggian, A Navuzzi, R De Beni
OBJECTIVES: Among the psychosocial interventions intended to reduce the behavioral and psychological symptoms of dementia (BPSD), doll therapy (DT) is increasingly used in clinical practice. Few studies on DT have been based on empirical data obtained with an adequate procedure; however, none have assessed its efficacy using an active control group, and the scales used to assess changes in BPSD are usually unreliable. The aim of the present study was to measure the impact of DT on people with severe dementia with a reliable, commonly used scale for assessing their BPSD, and the related distress in formal caregivers...
April 19, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29664058/relationships-between-rapid-eye-movement-sleep-behavior-disorder-and-neurodegenerative-diseases-clinical-assessments-biomarkers-and-treatment
#17
REVIEW
Min Li, Li Wang, Jiang-Hong Liu, Shu-Qin Zhan
Objective: Rapid eye movement sleep behavior disorder (RBD) is characterized by dream enactment and loss of muscle atonia during rapid eye movement sleep. RBD is closely related to α-synucleinopathies including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Many studies have investigated the markers of imaging and neurophysiological, genetic, cognitive, autonomic function of RBD and their predictive value for neurodegenerative diseases. This report reviewed the progress of these studies and discussed their limitations and future research directions...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29663065/-individual-activation-of-dementia-sufferers-in-a-home-setting-a-randomized-controlled-study
#18
Renate Stemmer, Elmar Gräßel, Martin Schmid
BACKGROUND AND OBJECTIVES: The present project investigated the hypothesis that a multimodal individual activation of people with mild to moderate dementia in the home setting during a 6-month intervention period leads to improved everyday practice and cognitive abilities compared to the control group. MATERIAL AND METHODS: Intervention: a practical activation was performed by relatives 6 days per week. Cognitive stimulation took place once a week and was done by an external person...
April 16, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29659622/the-association-of-single-and-combined-factors-of-sedentary-behavior-and-physical-activity-with-subjective-cognitive-complaints-among-community-dwelling-older-adults-cross-sectional-study
#19
Yuta Nemoto, Shinichiro Sato, Masaki Takahashi, Noriko Takeda, Munehiro Matsushita, Yoshinori Kitabatake, Kazushi Maruo, Takashi Arao
Subjective cognitive complaints (SCC) might be a meaningful indicator of dementia onset or mild cognitive impairment, and identifying the related factors of SCC could contribute to preventing these diseases. However, the relationship between SCC and lifestyle factors remains largely unproven. The purpose of this study was to examine the association of type of sedentary behavior, physical activity, or their combination with SCC among community-dwelling older adults. In 2016, 6677 community-living elderly were recruited to participate in a survey investigating cognition, physical activity, and sedentary behavior...
2018: PloS One
https://www.readbyqxmd.com/read/29653278/psychometric-validation-of-the-korean-version-of-the-camberwell-assessment-of-need-for-the-elderly-cane-k-in-dementia
#20
Myonghwa Park, Sun Kyung Kim, Miri Jeong, Song Ja Lee, Seon Hwa Kim, Jinha Kim, Dong Young Lee
PURPOSE: The prevalence of dementia has increased rapidly with an aging Korean population. Compared to those without dementia, individuals with dementia have more and complex needs. In this study, the Korean version of the Camberwell Assessment of Need for the Elderly (CANE-K) was evaluated to determine its suitability for individuals with dementia in Korea. METHODS: The CANE-K was developed following linguistic validation. The reliability of the measurement was examined with Cronbach's alpha coefficient...
April 10, 2018: Asian Nursing Research
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