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Dementia-related behaviors

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https://www.readbyqxmd.com/read/27911311/risk-factors-and-pathological-substrates-associated-with-agitation-aggression-in-alzheimer-s-disease-a-preliminary-study-using-nacc-data
#1
Simrin Sennik, Tom A Schweizer, Corinne E Fischer, David G Munoz
BACKGROUND: Neuropsychiatric symptoms are common manifestations of Alzheimer's disease (AD). A number of studies have targeted psychosis, i.e., hallucinations and delusions in AD, but few have assessed agitation/aggression in AD. OBJECTIVE: To investigate the risk factors and pathological substrates associated with presence [A(+)] and absence [A(-)] of agitation/aggression (A) in autopsy-confirmed AD. METHODS: Data was collected from the UDS data as of 2015 on the NACC database...
November 28, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27904027/retinal-vascular-changes-and-prospective-risk-of-disabling-dementia-the-circulatory-risk-in-communities-study-circs
#2
Hiroshige Jinnouchi, Akihiko Kitamura, Kazumasa Yamagishi, Masahiko Kiyama, Hironori Imano, Takeo Okada, Renzhe Cui, Mitsumasa Umesawa, Isao Muraki, Mina Hayama-Terada, Ryo Kawasaki, Tomoko Sankai, Tetsuya Ohira, Hiroyasu Iso
AIM: To investigate the association of retinal vascular changes with a risk of dementia in longitudinal population-based study. METHODS: We performed a nested case-control study of 3,718 persons, aged 40-89 years, enrolled between 1983 and 2004. Retinal vascular changes were observed in 351 cases with disabling dementia (average period before the onset, 11.2 years) and in 702 controls matched for sex, age, and baseline year. Incidence of disabling dementia was defined as individuals who received cares for disabilities including dementia-related symptoms and/or behavioral disturbance...
December 1, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27903322/non-use-of-day-care-services-for-dementia-in-singapore-a-dilemma-for-caregivers
#3
Shan Huang, Konstadina Griva, Christina A Bryant, Philip Yap
BACKGROUND: Day care services for patients with dementia (PWD) are generally under-utilized worldwide despite evidence of positive outcomes, such as improved behavioral, psychological, and cognitive functioning for patients, and reduced caregiver burden. This study sought to gain an in-depth understanding of the reasons for non-utilization of day care services in Singapore using qualitative methodology. METHODS: A purposive sample of 16 caregivers of PWD who had never attended day care services participated in semi-structured interviews...
December 1, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27903306/dementia-care-worker-stress-associations-with-unit-type-resident-and-work-environment-characteristics-a-cross-sectional-secondary-data-analysis-of-the-swiss-nursing-homes-human-resources-project-shurp
#4
Barbara Vogel, Sabina De Geest, Katharina Fierz, Sonja Beckmann, Franziska Zúñiga
BACKGROUND: Although caring for residents with dementia in nursing homes is associated with various stressors for care workers, the role of the unit type, and particularly the proportion of residents with dementia, remains unclear. This study aimed to explore associations between unit type and care worker stress, taking into account additional potential stressors. METHODS: This cross-sectional study was a secondary data analysis in the Swiss Nursing Homes Human Resources Project, which included data from 3,922 care workers from 156 Swiss nursing homes...
December 1, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27899296/targeting-the-norepinephrinergic-system-in-parkinson-s-disease-and-related-disorders-the-locus-coeruleus-story
#5
Yannick Vermeiren, Peter P De Deyn
Parkinson's disease (PD), dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are related, progressive and debilitating neurodegenerative disorders with hallmark features that include a variety of motor and non-motor symptoms (behavioral, autonomic and cognitive dysfunction). For almost half a century, the motor aspects have been attributed to Lewy pathology (LP) predominantly in the substantia nigra (SN), causing a major loss of dopaminergic neurons. However, the relative success of dopaminergic replacement therapies for alleviation of solely the parkinsonian features has prompted researchers to further explore other monoaminergic strategies which may tackle all PD-related aspects...
November 26, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27897609/a-video-based-intervention-on-and-evaluation-of-nursing-aides-therapeutic-communication-and-residents-agitation-during-mealtime-in-a-dementia-care-unit
#6
Lené Levy-Storms, Lesley M Harris, Xiao Chen
The researchers conducted a communication training intervention for certified nursing assistants (CNAs). The intervention aimed at improving CNAs' therapeutic techniques for relating to agitated residents during care. This study focused on an in-depth evaluation of mealtime interactions using videos. Sixteen CNAs and 16 residents living with dementia from one long-term care facility were videotaped during mealtime interactions before and after a therapeutic communication training program. Mixed-effect Poisson regression revealed no effect of the intervention as a whole on residents' refusals, but the intervention did improve CNAs' communication...
October 2016: Journal of Nutrition in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27896309/olfactory-stimulus-control-and-the-behavioral-pharmacology-of-remembering
#7
Mark Galizio
Behavior analytic approaches and techniques have much to offer to the study of remembering. There is currently great interest in the development of animal models of human memory processes in order to enhance understanding of the neurobiology of memory and treatment of dementia and related disorders. Because rodent models are so important in contemporary neuroscience and genetics, development of procedures to study various forms of memory in rodents is a point of emphasis. The sense of smell plays an important role in rodent behavior and use of olfactory stimuli has permitted demonstrations of complex forms of stimulus control that have also served as baselines for studying drug effects on remembering...
November 2016: Behav Anal (Wash D C)
https://www.readbyqxmd.com/read/27890543/hearing-care-intervention-for-persons-with-dementia-a-pilot-study
#8
Sara K Mamo, Olivia Nirmalasari, Carrie L Nieman, Matthew K McNabney, Allison Simpson, Esther S Oh, Frank R Lin
OBJECTIVE: Hearing loss is a commonly unmet need among adults with dementia that may exacerbate common dementia-related behavioral symptoms. Accessing traditional audiology services for hearing loss is a challenge because of high cost and time commitment. To improve accessibility and affordability of hearing treatment for persons with dementia, there is a need for unique service delivery models. The purpose of this study is to test a novel hearing intervention for persons with dementia and family caregivers delivered in outpatient settings...
September 22, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27866729/molecular-imaging-in-the-diagnosis-of-alzheimer-s-disease-and-related-disorders
#9
REVIEW
L Koric, E Guedj, M O Habert, F Semah, P Branger, P Payoux, F Le Jeune
INTRODUCTION: The diagnosis of Alzheimer's disease (AD) and its related disorders rely on clinical criteria. There is, however, a large clinical overlap between the different neurodegenerative diseases affecting cognition and, frequently, there are diagnostic uncertainties with atypical clinical presentations. Current clinical practices can now regularly use positron emission tomography (PET) and single-photon emission computed tomography (SPECT) molecular imaging to help resolve such uncertainties...
November 17, 2016: Revue Neurologique
https://www.readbyqxmd.com/read/27866485/determinants-of-the-nurses-and-nursing-assistants-request-for-antipsychotics-for-people-with-dementia
#10
Sarah I M Janus, Jeannette G van Manen, Maarten J IJzerman, Marloes Bisseling, Constance H C Drossaert, Sytse U Zuidema
BACKGROUND: Although physicians are responsible for writing the antipsychotic prescriptions for patients with dementia, the initiative is often taken by nurses or nursing assistants. To reduce antipsychotics uses, one needs to understand the reasons for nurses and nursing assistants to request them. This study gives an overview of the influencing factors for this request based on the Theory of Planned Behavior in which attitude, beliefs, and behavioral control is thought to influence the intention to request, which in turn affects the behavior to request for a prescription...
November 21, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27859539/clinicopathologic-heterogeneity-in-ftdp-17-due-to-mapt-p-p301l-mutation-including-a-patient-with-globular-glial-tauopathy
#11
Pawel Tacik, Monica Sanchez-Contreras, Michael DeTure, Melissa E Murray, Rosa Rademakers, Owen A Ross, Zbigniew K Wszolek, Joseph E Parisi, David S Knopman, Ronald C Petersen, Dennis W Dickson
AIM: The p.P301L mutation in microtubule-associated protein tau (MAPT) is a common cause of frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17). We compare clinicopathologic features of five unrelated and three related (brother, sister and cousin) patients with FTDP-17 due to p.P301L mutation. METHODS: Genealogical, clinical, neuropathologic, and genetic data were reviewed from eight individuals RESULTS: The series consisted of five men and three women with an average age of death of 58 years (52-65 years) and average disease duration of 9 years (3-14 years)...
November 8, 2016: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/27858712/self-consciousness-deficits-in-alzheimer-s-disease-and-frontotemporal-dementia
#12
Eva Ma Arroyo-Anlló, Adèle Turpin Boustonb, Marie-Noëlle Fargeau, Begoña Orgaz Baz, Roger Gil
Self-consciousness (SC) is multifaceted and considered to be the consciousness of one's own mental states. The main aim of this paper is to compare SC in patients with Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD). Three groups (control and patient groups) of 23 subjects each were assessed using an SC questionnaire. Both types of dementia clearly induce an alteration of SC. The bvFTD group showed a greater impairment in SC than the AD and control groups. The SC score was strongly associated with frontal functions...
November 14, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27837033/pain-in-dementia-use-of-observational-pain-assessment-tools-by-people-who-are-not-health-professionals
#13
Delaine A Ammaturo, Thomas Hadjistavropoulos, Jaime Williams
OBJECTIVE: Pain is prevalent among older adults but is often underestimated and undertreated, especially in people with severe dementia who have limited ability to self-report pain. Pain in patients with moderate to severe dementia can be assessed using observational tools. Informal caregivers (relatives of seniors with dementia) are an untapped assessor group who often bear the responsibility of care for their loved ones. Our objective was to evaluate the ability of laypeople to assess pain using observational measures originally developed for use by health care professionals...
November 10, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27834773/validation-of-the-korean-version-of-the-lewy-body-composite-risk-score-k-lbcrs
#14
Hui Jin Ryu, Minyoung Kim, Yeonsil Moon, Yeji Choi, Jiyoung Han, James E Galvin, Seol-Heui Han
The Lewy body composite risk score (LBCRS) is a useful clinical screening tool to help determine whether the dementia is related to Lewy body pathology. The purpose of this study is to verify reliability, validity, and diagnostic usefulness of Korean version of LBCRS (K-LBCRS). CDR-sum of boxes, Mini-Mental State Examination, and standardized scales related to cognition, mood, behavior, and motor function were administered to a total of 107 subjects, including 30 dementia with Lewy bodies (DLB), 54 Alzheimer's disease (AD), and 23 cognitively normal elderly people and their collateral informants...
November 9, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27833221/profile-of-patients-attending-psychogeriatric-clinic-in-a-tertiary-care-setting
#15
Suresh Neethu, P V Indu, Prabhakaran Anil
BACKGROUND: Proportion of elderly is increasing among the total population of Kerala, and mental health problems of this group are unique. OBJECTIVES: To assess the clinical and sociodemographic profile of patients attending Psychogeriatric Clinic in a tertiary care center and to study the correlation of sociodemographic and clinical variables with psychiatric diagnoses in this population. MATERIALS AND METHODS: A retrospective chart review of patients, who attended the Psychogeriatric Clinic of a tertiary care center over a period of 1 year, was done...
September 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27819787/-insomnia-a-severe-health-care-problem
#16
Ana Gabriela Sánchez-Cárdenas, Christian Navarro-Gerrard, Haiko Nellen-Hummel, José Halabe-Cherem
The magnitude which sleep has on personal well-being is similar to the effects of diet and exercise. Sleep deprivation has severe negative effects on an individual's overall health, and this is usually overseen. From 30 to 40 % of the population has presented insomnia at a certain moment of life and from 9 to 15 % have evolved into a chronic and severe insomnia. Recent investigations have related sleep deprivation with obesity, metabolic disorders, heart disease, mental health problems and dementia. Recently, more investigations have focused on the multiple alterations suffered by the immune system in cases of sleep deprivation...
November 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27809556/individualized-formulation-led-interventions-for-analyzing-and-managing-challenging-behavior-of-people-with-dementia-an-integrative-review
#17
Daniela Holle, Margareta Halek, Bernhard Holle, Christiane Pinkert
OBJECTIVE: Individualized formulation-led interventions offer a promising approach for analyzing and managing challenging behaviors in people with dementia. Little is known about which individualized formulation-led interventions exist and what effects these interventions have on people with dementia and their caregivers. Therefore, the review aims to describe and examine existing interventions and to review their evidence. METHODS: An integrative review of individualized formulation-led interventions for managing challenging behavior in people with dementia was conducted...
November 3, 2016: Aging & Mental Health
https://www.readbyqxmd.com/read/27802239/rapidly-progressive-frontotemporal-dementia-associated-with-mapt-mutation%C3%A2-g389r
#18
Lin Sun, Kathryn Chen, Xia Li, Shifu Xiao
Frontotemporal dementia includes a large spectrum of neurodegenerative disorders. Here, we report the case of a young patient with MAPT mutation G389R, who was 27 years old when he progressively developed severe behavioral disturbances. Initially, he presented with slowly progressive personality change. After 1 year, he exhibited moderate dementia with extrapyramidal and pyramidal symptoms. MRI showed frontotemporal atrophy. He rapidly progressed to severe dementia 3 years after onset. Genetic testing revealed a heterozygous guanine to cytosine mutation at the first base of codon 389 (c...
October 11, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27772752/role-of-neurodevelopment-involved-genes-in-psychiatric-comorbidities-and-modulation-of-inflammatory-processes-in-alzheimer-s-disease
#19
Porcelli Stefano, Crisafulli Concetta, Donato Luigi, Calabrò Marco, Politis Antonis, Liappas Ioannis, Albani Diego, Atti Anna Rita, Salfi Raffaele, Raimondi Ilaria, Forloni Gianluigi, Papadimitriou George N, De Ronchi Diana, Serretti Alessandro
INTRODUCTION: With the increase of the population's average age, Alzheimer's disease (AD) is becoming one of the most disabling diseases worldwide. Recently, neurodevelopment processes have been involved in the AD etiopathogenesis. Genetic studies in this field could contribute to our knowledge and suggest new molecular targets for possible treatments. METHODS: Our primary aim was to investigate the associations among single nucleotide polymorphisms (SNPs) within neurodevelopment related genes (BDNF, ST8SIA2, C15orf32, NCAPG2, ESYT2, WDR60, LOC154822, VIPR2, GSK3B, NR1I2, ZNF804A, SP4) and AD...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27772665/-reconciliating-neurology-and-psychiatry-the-prototypical-case-of-frontotemporal-dementia
#20
J Lagarde, M Sarazin
Frontotemporal degeneration (FTD) in its behavioral variant (bvFTD) is probably one of the conditions that best illustrates the links between psychiatry and neurology. It is indeed admitted that between a third and half of patients with this condition, especially in early-onset forms, receive an initial diagnosis of psychiatric disorder (depression, schizophrenia, bipolar disorder) and are then referred to a psychiatric ward. BvFTD can thus be considered a neurological disorder with a psychiatric presentation...
October 20, 2016: L'Encéphale
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