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Dementia-related behaviors

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https://www.readbyqxmd.com/read/28332736/dementia-related-restlessness-relationship-to-characteristics-of-persons-with-dementia-and-family-caregivers
#1
Natalie G Regier, Laura N Gitlin
OBJECTIVE: Dementia-related restlessness is commonly endorsed by caregivers but not well understood. This study examines differences in characteristics (demographics, cognitive status, physical function, pain, and mood) of persons with dementia whose caregivers endorse restlessness versus those who do not. We also examine the relationship of restlessness to caregiver well-being including burden, upset with behaviors, mastery, and depressive symptomatology. METHODS: We combined baseline data from three caregiver intervention studies of community-dwelling persons with dementia who exhibited neuropsychiatric symptoms (n = 569) as measured by the Agitated Behaviors in Dementia Scale...
March 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28331324/update-on-the-treatment-of-parkinson-s-disease-psychosis-role-of-pimavanserin
#2
REVIEW
Brianna L Combs, Arthur G Cox
Parkinson's disease (PD) has a prevalence of nearly 1 million people in the USA, with increasing incidence in the elderly population. Generally, the age of presentation is between 55 and 65 years, with the likelihood of diagnosis increasing as patients reach the age of 80 years or above. Some of the common treatments for PD increase dopamine levels in the brain. Dopaminergic therapy helps to improve motor and non-motor symptoms, but it is not without risks. Dopaminergic therapy can cause confusion, delirium, and psychotic-like behavior...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28329827/the-influence-of-the-physical-envirnment-on-residents-with-dementia-in-long-term-care-settings-a-review-of-the-empirical-literature
#3
Habib Chaudhury, Heather A Cooke, Heather Cowie, Leila Razaghi
Background and Objectives: The physical environment in long-term care facilities has an important role in the care of residents with dementia. This paper presents a literature review focusing on recent empirical research in this area and situates the research with therapeutic goals related to the physical environment. Research Design and Methods: A comprehensive literature search was conducted in Ageline, PsychINFO, CINAHL, Medline and Google Scholar databases to identify relevant articles...
March 10, 2017: Gerontologist
https://www.readbyqxmd.com/read/28322152/serotonin-receptor-binding-characteristics-of-geissoschizine-methyl-ether-an-indole-alkaloid-in-uncaria-hook
#4
Yasushi Ikarashi, Kyoji Sekiguchi, Kazushige Mizoguchi
Geissoschizine methyl ether (GM) is one of the indole alkaloids in Uncaria hook, and an active ingredient of yokukansan (YKS) that improves behavioral and psychological symptoms of dementia (BPSD) in patients with several types of dementia. The pharmacological action of GM has been related to various serotonin (5-HT) receptor subtypes. Here we describe previous findings and our own data to review the binding characteristics of GM to the 5-HT receptor subtypes. Competitive receptor-binding assays showed that GM bound the following 5-HT receptor subtypes: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT4, 5-HT5A, 5-HT6, and 5-HT7...
March 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28302047/neuroinflammation-as-a-common-mechanism-associated-with-the-modifiable-risk-factors-for-alzheimer-s-and-parkinson-s-diseases
#5
Jordan Alexander McKenzie, Lindsay J Spielman, Caitlin B Pointer, Jessica R Lowry, Ekta Bajwa, Carolyn W Lee, Andis Klegeris
Alzheimer's disease (AD) and Parkinson's disease (PD) are among the most common causes of dementia, which increasingly contribute to morbidity and mortality worldwide. A common hallmark in the pathogenesis of these two diseases is neuroinflammation, which is initially triggered by the presence of pathological structures associated with these disorders. Chronic neuroinflammation is sustained by persistent and aberrant microglial activation in the brain, which results in damage and death of neighboring cells, including neurons and glial cells...
March 15, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28295134/impact-of-the-reach-ii-and-reach-va-dementia-caregiver-interventions-on-healthcare-costs
#6
Linda O Nichols, Jennifer Martindale-Adams, Carolyn W Zhu, Erin K Kaplan, Jeffrey K Zuber, Teresa M Waters
OBJECTIVE: Examine caregiver and care recipient healthcare costs associated with caregivers' participation in Resources for Enhancing Alzheimer's Caregivers Health (REACH II or REACH VA) behavioral interventions to improve coping skills and care recipient management. DESIGN: RCT (REACH II); propensity-score matched, retrospective cohort study (REACH VA). SETTING: Five community sites (REACH II); 24 VA facilities (REACH VA). PARTICIPANTS: Care recipients with Alzheimer's disease and related dementias (ADRD) and their caregivers who participated in REACH II study (analysis sample of 110 caregivers and 197 care recipients); care recipients whose caregivers participated in REACH VA and a propensity matched control group (analysis sample of 491)...
March 13, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28289811/caffeine-impact-on-working-memory-related-network-activation-patterns-in-early-stages-of-cognitive-decline
#7
Sven Haller, Marie-Louise Montandon, Cristelle Rodriguez, Dominik Moser, Simona Toma, Jeremy Hofmeister, Panteleimon Giannakopoulos
PURPOSE: Recent evidence indicates that caffeine may have a beneficial effect on cognitive decline and dementia. The current investigation assessed the effect of acute caffeine administration on working memory during the earliest stage of cognitive decline in elderly participants. METHODS: The study includes consecutive 45 elderly controls and 18 individuals with mild cognitive impairment (MCI, 71.6 ± 4.7 years, 7 females). During neuropsychological follow-up at 18 months, 24 controls remained stable (sCON, 70...
March 13, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28289749/motor-speech-phenotypes-of-frontotemporal-dementia-primary-progressive-aphasia-and-progressive-apraxia-of-speech
#8
Matthew L Poole, Amy Brodtmann, David Darby, Adam P Vogel
Purpose: Our purpose was to create a comprehensive review of speech impairment in frontotemporal dementia (FTD), primary progressive aphasia (PPA), and progressive apraxia of speech in order to identify the most effective measures for diagnosis and monitoring, and to elucidate associations between speech and neuroimaging. Method: Speech and neuroimaging data described in studies of FTD and PPA were systematically reviewed. A meta-analysis was conducted for speech measures that were used consistently in multiple studies...
March 13, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28288787/evolution-of-autobiographical-memory-impairments-in-alzheimer-s-disease-and-frontotemporal-dementia-a-longitudinal-neuroimaging-study
#9
Muireann Irish, Ramon Landin-Romero, Annu Mothakunnel, Siddharth Ramanan, Sharpley Hsieh, John R Hodges, Olivier Piguet
Compromised autobiographical memory (ABM) retrieval is well established in dementia, attributable to degeneration of a core memory brain network. It remains unclear, however, how the progressive spread of atrophy with advancing disease severity impacts ABM retrieval across life epochs. To this end, we conducted a longitudinal study of recent and remote ABM in Alzheimer's disease (AD, n =11), and a frontotemporal lobar degeneration group (FTD, n =13) comprising 7 behavioral variant FTD and 6 semantic dementia patients, in comparison with 23 healthy older Controls...
March 10, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28285610/the-clinical-course-and-interrelations-of-dementia-related-symptoms
#10
Miriam L Haaksma, Jeannie-Marie S Leoutsakos, Jonne A E Bremer, Pauline Aalten, Inez H G B Ramakers, Frans R J Verhey, Marcel G M Olde Rikkert, René J F Melis
BACKGROUND: Dementia is a neurodegenerative syndrome that interferes with multiple aspects of life, including cognition, daily functioning, and behavior. Despite the large heterogeneity in symptom development, these three domains are seldom studied simultaneously. This study investigates how trajectories of these domains are interrelated within individuals over time, and how they in turn are related to dementia severity and quality of life (QoL). METHODS: We used data from a longitudinal clinical cohort study, including 331 dementia patients...
March 13, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28283381/a-comprehensive-review-of-the-quality-and-feasibility-of-dementia-assessment-measures-the-dementia-outcomes-measurement-suite
#11
REVIEW
Adam Bentvelzen, Liesbeth Aerts, Katrin Seeher, Jacqueline Wesson, Henry Brodaty
The diagnosis of dementia and the management of its associated symptoms are aided by high-quality assessment tools. However, there is disagreement on the optimal tools among abundant alternatives and lack of consistent quality standards across the different domains of dementia-related change (ie, cognition, severity, function, behavioral and psychological symptoms, delirium, quality of life). Standardization is difficult because the relevance of a measurement tool for health professionals may depend on the clinical setting and on the dementia type and severity...
March 7, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28282722/attentional-avoidant-biases-as-mediators-in-the-association-between-experiential-avoidance-and-blood-pressure-in-dementia-family-caregivers
#12
María Márquez-González, Isabel Cabrera, Andrés Losada, Bob G Knight
OBJECTIVES: Experiential avoidance in caregiving (EAC) has been found to be related with dementia family caregivers´ distress and blood pressure (BP). The association between EAC and avoidant attentional biases to emotional stimuli in dementia caregivers, and the potential mediating role of these attentional biases in the association between EAC and increased BP are explored. METHOD: Seventy nine dementia family caregivers performed a dot-probe task with emotional pictures (distressing and positive) varying in content (general vs...
March 2, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28282081/-impact-of-facial-emotional-recognition-alterations-in-dementia-of-the-alzheimer-type
#13
Wanda Rubinstein, Florencia Cossini, Daniel Politis
Face recognition of basic emotions is independent of other deficits in dementia of the Alzheimer type. Among these deficits, there is disagreement about what emotions are more difficult to recognize. Our aim was to study the presence of alterations in the process of facial recognition of basic emotions, and to investigate if there were differences in the recognition of each type of emotion in Alzheimer's disease. With three tests of recognition of basic facial emotions we evaluated 29 patients who had been diagnosed with dementia of the Alzheimer type and 18 control subjects...
July 2016: Vertex: Revista Argentina de Psiquiatriá
https://www.readbyqxmd.com/read/28270179/blood-cholesterol-in-late-life-and-cognitive-decline-a-longitudinal-study-of-the-chinese-elderly
#14
Chaoran Ma, Zhaoxue Yin, Pengfei Zhu, Jiesi Luo, Xiaoming Shi, Xiang Gao
BACKGROUND: Previous studies regarding the lipid-cognition relation in older adults are limited and have generated mixed results. We thus examined whether higher blood cholesterol concentrations were associated with faster cognitive decline in a community-based longitudinal study of Chinese elderly. METHODS: The study included 1,159 Chinese adults aged over 60 years (women: 48.7%, mean age: 79.4 years), who were free of dementia, Parkinson disease and stroke at the baseline...
March 7, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28269777/what-is-the-relationship-of-traumatic-brain-injury-to-dementia
#15
Mario F Mendez
There is a long history linking traumatic brain injury (TBI) with the development of dementia. Despite significant reservations, such as recall bias or concluding causality for TBI, a summary of recent research points to several conclusions on the TBI-dementia relationship. 1) Increasing severity of a single moderate-to-severe TBI increases the risk of subsequent Alzheimer's disease (AD), the most common type of dementia. 2) Repetitive, often subconcussive, mild TBIs increases the risk for chronic traumatic encephalopathy (CTE), a degenerative neuropathology...
March 2, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28269769/do-hearing-aids-influence-behavioral-and-psychological-symptoms-of-dementia-and-quality-of-life-in-hearing-impaired-alzheimer-s-disease-patients-and-their-caregivers
#16
Arnaud Adrait, Xavier Perrot, Marie-France Nguyen, Marine Gueugnon, Charles Petitot, Lionel Collet, Adeline Roux, Marc Bonnefoy
BACKGROUND: It has been suggested that age-related hearing loss (ARHL) and Alzheimer's disease (AD) are commonly associated. OBJECTIVE: The Alzheimer Disease, Presbycusis and Hearing Aids (ADPHA) clinical trial assessed the influence of hearing aids (HAs) on patients affected by ARHL and AD, as judged by behavioral symptoms and functional abilities, as well as patient and caregiver quality of life (QoL). METHODS: A multicenter double-blind randomized placebo-controlled trial, with a semi-crossover procedure over 12 months, was conducted from 2006 to 2012...
March 2, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28265571/validation-of-the-italian-version-of-the-caregiver-abuse-screen-among-family-caregivers-of-older-people-with-alzheimer-s-disease
#17
RANDOMIZED CONTROLLED TRIAL
Maria Gabriella Melchiorre, Mirko Di Rosa, Francesco Barbabella, Norma Barbini, Fabrizia Lattanzio, Carlos Chiatti
Introduction. Elder abuse is often a hidden phenomenon and, in many cases, screening practices are difficult to implement among older people with dementia. The Caregiver Abuse Screen (CASE) is a useful tool which is administered to family caregivers for detecting their potential abusive behavior. Objectives. To validate the Italian version of the CASE tool in the context of family caregiving of older people with Alzheimer's disease (AD) and to identify risk factors for elder abuse in Italy. Methods. The CASE test was administered to 438 caregivers, recruited in the Up-Tech study...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28265458/diagnosing-the-frontal-variant-of-alzheimer-s-disease-a-clinician-s-yellow-brick-road
#18
REVIEW
Russell P Sawyer, Federico Rodriguez-Porcel, Matthew Hagen, Rhonna Shatz, Alberto J Espay
BACKGROUND: Disruption of the frontal lobes and its associated networks are a common consequence of neurodegenerative disorders. Given the wide range of cognitive, behavioral and motor processes in which the frontal lobes are involved, there can be a great variety of manifestations depending on the pathology distribution. The most common are the behavioral variant of frontotemporal dementia (bvFTD) and the frontal variant of Alzheimer's disease (fvAD), which are particularly challenging to disentangle...
2017: Journal of Clinical Movement Disorders
https://www.readbyqxmd.com/read/28260539/background-characteristics-and-treatment-related-factors-associated-with-treatment-success-or-failure-in-a-non-pharmacological-intervention-for-dementia-caregivers
#19
Karen C Rose, Laura N Gitlin
BACKGROUND: Non-pharmacological interventions for persons with dementia often rely on family caregivers for implementation. However, caregivers differ in their readiness to use strategies. This study examines dyadic characteristics and treatment-related mechanisms associated with treatment success (high readiness to use strategies) and failure (low readiness to use strategies) at the conclusion of the Advancing Caregiver Training (ACT) intervention. METHODS: Caregiver and person with dementia characteristics and treatment-related variables (treatment participation, number and type of strategies introduced and enacted) were examined in 110 caregivers in intervention...
March 6, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28251765/factors-related-to-continuous-and-discontinuous-attendance-at-memory-clinics
#20
N Hishikawa, Y Fukui, Y Nakano, R Morihara, M Takemoto, K Sato, T Yamashita, Y Ohta, K Abe
BACKGROUND AND PURPOSE: Few studies have examined why some patients with dementia stop attending medical consultations. We conducted a retrospective study to investigate factors associated with discontinuous clinic attendance. METHODS: Participants were 988 patients with dementia from university hospital (UH) clinics and affiliated local hospital (LH) clinics. We compared continuous and discontinuous attenders on cognitive and affective functions and activities of daily living (ADL), and also compared UH and LH patients (UH: continuous, n = 176; discontinuous, n = 207; LH: continuous, n = 418; discontinuous, n = 187)...
March 1, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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