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IGF-1 AND supplement

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https://www.readbyqxmd.com/read/29790945/the-effects-of-protein-supplementation-of-fall-calving-beef-cows-on-pre-and-postpartum-plasma-insulin-glucose-and-igf-i-and-postnatal-growth-and-plasma-insulin-and-igf-i-of-calves
#1
Kyle J McLean, Brit H Boehmer, Leon J Spicer, Robert P Wettemann
Fall calving (September to October) cows (n = 189 calvings in 5 replications; body weight [BW] = 626 ± 6 kg, body condition score [BCS] = 4.76 ± 0.06) grazing native dormant range were used to determine the effects of protein supplementation on performance and endocrine function of cows and calves. Cows were individually fed either a control (CON; 1.82 kg/d of 38% crude protein [CP]) or restricted (RES; 0.2 kg/d of 8% CP) protein supplement from mid-November to mid-March for 6 consecutive years. During each year, cows were reassigned dietary treatments according to calving date and BCS, and half of the CON and half of the RES cows remained on the same diets as the previous year and the other halves were assigned to the other diet...
May 22, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29746517/combined-treatment-with-electrical-stimulation-and-insulin-like-growth-factor-1-promotes-bone-regeneration-in-vitro
#2
Zhiping Qi, Peng Xia, Su Pan, Shuang Zheng, Chuan Fu, Yuxin Chang, Yue Ma, Jincheng Wang, Xiaoyu Yang
Electrical stimulation (ES) and insulin-like growth factor-1 (IGF-1) are widely used in bone regeneration because of their osteogenic activity. However, the combined effects of ES and supplemental IGF-1 on the whole bone formation process remain unclear. In this study, fluorescence staining and an MTT assay were first utilized to observe the influence of ES and IGF-1 on MC3T3-E1 cell proliferation and adhesion in vitro. Subsequently, osteogenic differentiation was evaluated by the alkaline phosphatase activity (ALP) and the expression of osteogenic marker genes...
2018: PloS One
https://www.readbyqxmd.com/read/29742726/igf-and-igfbp-as-an-index-for-discrimination-between-vitamin-d-supplementation-responders-and-nonresponders-in-overweight-saudi-subjects
#3
Nasser M Al-Daghri, Sobhy M Yakout, Kaiser Wani, Malak Nawaz Khan Khattak, Spiro D Garbis, George P Chrousos, Omar S Al-Attas, Majed S Alokail
Vitamin D deficiency is common in the Kingdom of Saudi Arabia (KSA). Therefore, it is significant to recognize which biochemical markers modulate serum 25 hydroxyvitamin D (25(OH)D) in response to vitamin D supplementation in such a population. Our aim was to study the correlation of insulin-like growth factor (IGF) and insulin growth factor binding protein (IGFBP) with serum 25(OH)D in response to vitamin D supplementation in a Saudi population. A total of 199 (89 males/110 females) vitamin D deficient subjects (25(OH)D level <50 nmol/L), aged 40...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29730750/effect-of-selenium-nanoparticle-supplementation-on-tissue-inflammation-blood-cell-count-and-igf-1-levels-in-spinal-cord-injury-induced-rats
#4
Moosa Javdani, Atefeh Habibi, Sadegh Shirian, Gholam Ali Kojouri, Farzaneh Hosseini
Selenium is known to be a neuroprotective agent in respect to a number of neuronal diseases and pain. The aim of this study was to evaluate the neuroprotective effect of the oral administration of selenium nanoparticles in rats with spinal cord injury (SCI). Forty adult female rats were randomly assigned to two equal groups as experimental and control. Under general inhalation anesthesia, in both groups, SCI was created, at the T9-10 level of the column. On the third day after the operation, a supplement of selenium nanoparticle was administered to the experimental group at 0...
May 5, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29730709/lysine-supplement-benefits-the-growth-performance-protein-synthesis-and-muscle-development-of-megalobrama-amblycephala-fed-diets-with-fish-meal-replaced-by-rice-protein-concentrate
#5
Wan-Cun Cai, Wen-Bin Liu, Guang-Zhen Jiang, Kai-Zhou Wang, Cun-Xin Sun, Xiang-Fei Li
This study aimed to investigate the effects of lysine supplement on the growth performance of blunt snout bream Megalobrama amblycephala fed diets with fish meal (FM) replaced by rice protein concentrate (RPC) with the potential mechanisms characterized. Fish were fed three diets, including the FM diet (containing FM), the RPC diet (FM replaced by RPC), and the MRPC diet (the RPC diet supplemented with lysine) for 8 weeks. Weight gain, protein efficiency ratio, and nitrogen and energy utilization of fish fed the FM diet were all significantly higher than those of the RPC treatment, but they showed no statistical difference with those of the MRPC group...
May 5, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29724029/somatotropic-axis-dysfunction-in-non-alcoholic-fatty-liver-disease-beneficial-hepatic-and-systemic-effects-of-hormone-supplementation
#6
Daniel Cabrera, Claudio Cabello-Verrugio, Nancy Solís, Diego San Martín, Catalina Cofré, Margarita Pizarro, Juan Pablo Arab, Johanna Abrigo, Fabián Campos, Betzabé Irigoyen, Gonzalo Carrasco-Avino, Katiuska Bezares, Valentina Riquelme, Arnoldo Riquelme, Marco Arrese, Francisco Barrera
BACKGROUND: Somatotropic axis dysfunction associated with non-alcoholic fatty liver disease (NAFLD) has potential multisystemic detrimental effects. Here, we analysed the effects of growth hormone (GH) and insulin -like growth factor-1 (IGF-1) supplementation on liver histology, adipokine profile and muscle function in an NAFLD model. METHODS: C57BL/6 mice were fed with a high fat diet (HFD) for 12 weeks and were separated into three groups treated for 4 weeks with: (1) High fat diet (HFD) ( n = 10); (2) HFD + GH 9 &mu;g/g/d ( n = 10); (3) HFD + IGF-1 0...
May 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29717686/supplementing-sow-diets-with-palm-oil-during-late-gestation-and-lactation-effects-on-milk-production-sow-hormonal-profiles-and-growth-and-development-of-her-offspring
#7
J Laws, D T Juniper, I J Lean, E Amusquivar, E Herrera, P F Dodds, L Clarke
The supplementing of sow diets with lipids during pregnancy and lactation has been shown to reduce sow condition loss and improve piglet performance. The aim of this study was to determine the effects of supplemental palm oil (PO) on sow performance, plasma metabolites and hormones, milk profiles and pre-weaning piglet development. A commercial sow ration (C) or an experimental diet supplemented with 10% extra energy in the form of PO, were provided from day 90 of gestation until weaning (24 to 28 days postpartum) in two groups of eight multiparous sows...
May 2, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29706427/effect-of-acute-stressors-adrenocorticotropic-hormone-administration-and-cortisol-release-on-milk-yield-the-expression-of-key-genes-proliferation-and-apoptosis-in-goat-mammary-epithelial-cells
#8
G F Bomfim, G K F Merighe, S A de Oliveira, J A Negrao
Cortisol is essential to milk synthesis; however, different acute stressors and the exogenous administration of adrenocorticotropic hormone (ACTH) decrease milk yield. Therefore, the effect of cortisol on milk yield and its influence on the survival of mammary epithelial cells have not been fully elucidated. In this context, the objective of this study was to evaluate the effect of cortisol on the expression of growth hormone receptor (GHR), insulin-like growth factor type 1 (IGF1), insulin-like growth factor type 1 receptor (IGF1R), insulin-like growth factor-binding protein 3 and 5 (IGFBP3 and IGFBP5), BAX, and BCL2 genes on the proliferation and apoptotic rates of mammary epithelial cells, and on milk yield in Saanen goats...
April 26, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29663652/a-longitudinal-study-of-serum-insulin-like-growth-factor-i-igf-i-levels-over-six-years-in-a-large-cohort-of-children-and-adolescents-with-type-1-diabetes-mellitus-a-marker-reflecting-diabetic-retinopathy
#9
Daniel Öberg, Jenny Salemyr, Eva Örtqvist, Anders Juul, Peter Bang
OBJECTIVE: To evaluate longitudinal serum IGF-I in a large cohort of children and adolescents with type 1 diabetes in relation to HbA1c, age, diabetes duration, and BMI, its association to height and retinopathy, and in comparison with healthy subject references. RESEARCH DESIGN AND METHODS: A total of 2,683 serum IGF-I values were obtained from 806 children and adolescents with T1DM, from annual blood samples for up to 6 consecutive years. RESULTS: In a multiple regression analysis IGF-I values were negatively correlated to HbA1c and diabetes duration, and positively correlated to BMI (p<0...
April 16, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29661746/effects-of-oral-vitamin-d-3-supplementation-in-stage-3-chronic-kidney-disease-subjects-insulin-resistance-syndrome-and-hormonal-disturb-interactions
#10
Amina Tahar, Faiza Zerdoumi, Messaoud Saidani, Lakhdar Griene, Elhadj-Ahmed Koceir
The 1-25-hydroxyvitamine D (1-25OHD) or calcitriol deficiency in chronic kidney disease (CKD) patients was associated with increases vascular calcification risk, nephrons reduction, bone deficit and cardiovascular mortality by atherosclerosis. The objective of this study was to investigate the pleiotropic effects of 200.000 IU (D200 group) every 3 months versus 30.000 IU (D30 group) every month dose vitamin D supplementation in stage 3 CKD patients. A cohort of 132 adult subjects was randomized into 2 groups according to dose vitamin D supplementation in deficient subjects (25OHD <50 nmol/L or <20 ng/mL)...
April 16, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29649340/the-relationship-between-alkaline-phosphatase-and-bone-alkaline-phosphatase-activity-and-the-growth-hormone-insulin-like-growth-factor-1-axis-and-vitamin-d-status-in-children-with-growth-hormone-deficiency
#11
Ewelina Witkowska-Sędek, Anna Stelmaszczyk-Emmel, Anna Majcher, Urszula Demkow, Beata Pyrżak
The relationships between bone turnover, the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and vitamin D are complex, but still not fully explained. The GH/IGF-1 axis and vitamin D can mutually modulate each other's metabolism and influence the activation of cell proliferation, maturation, and mineralization as well as bone resorption. The aim of this study was to evaluate the reciprocal associations between bone formation markers [alkaline phosphatase (ALP), bone alkaline phosphatase (BALP)], the GH/IGF-1 axis and 25-hydroxyvitamin D [25(OH)D] in children with growth hormone deficiency at baseline and during recombinant human growth hormone (rhGH) therapy...
April 13, 2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29624099/use-of-electronic-health-records-to-characterize-a-rare-disease-in-the-usa-treatment-comorbidities-and-follow-up-trends-among-patients-with-a-confirmed-diagnosis-of-acromegaly
#12
Julie M Silverstein, Erin D Roe, Kashif M Munir, Janet L Fox, Birol Emir, Maria Kouznetsova, Lois E Lamerato, Donna King
Purpose Understanding of acromegaly disease management is hampered in the US by lack of a national registry. We describe medical management in a population with confirmed acromegaly. Methods Inpatient and outpatient Electronic Health Records (EHR) were used to create a database of de-identified patients assigned the Acromegaly and Gigantism ICD-9 code and/or an appropriate pituitary procedure code at one of four regional hospital systems over a 6-11 year period. Information regarding demographics, medical history, labs, procedures and medications was collected and supplemented with a chart review to validate the diagnosis of acromegaly...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29574310/high-serum-igf-1-levels-are-associated-with-pregnancy-loss-following-frozen-thawed-euploid-embryo-transfer-cycles
#13
Mohamad Irani, Dimitrios Nasioudis, Steven S Witkin, Vinay Gunnala, Steven D Spandorfer
An elevated level of insulin growth factor (IGF-1) in rat uterine fluid has been shown to exert detrimental effects of embryo development possibly leading to an increase in pregnancy loss. Interestingly, the administration of somatostatin to rats undergoing superovulation reduced IGF-1 levels in uterine luminal fluid and thus reversed its deleterious effects on embryo development and increased the number of normal embryos. Therefore, we investigated whether serum levels of IGF-1 correlate with the incidence of pregnancy loss following IVF...
March 16, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29562339/dietary-chlorogenic-acid-improves-growth-performance-of-weaned-pigs-through-maintaining-antioxidant-capacity-and-intestinal-digestion-and-absorption-function
#14
Jiali Chen, Yan Li, Bing Yu, Daiwen Chen, Xiangbing Mao, Ping Zheng, Junqiu Luo, Jun He
Chlorogenic acid (CGA) is a natural phenolic acid, which is an important component of biologically active dietary phenols isolated from various species. Two experiments were conducted to investigate the effects of CGA on growth performance, antioxidant capacity, nutrient digestibility, diarrhea incidence, intestinal digestion and absorption function, and the expression levels of intestinal digestion and absorption-related genes in weaned pigs. In Exp. 1, 200 weaned pigs were randomly allotted to four dietary treatments and fed with a basal diet or a basal diet supplemented with 250, 500, or 1,000 mg/kg CGA, respectively, in a 14-d trial...
April 3, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29524195/maternal-selenium-supplementation-enhanced-skeletal-muscle-development-through-increasing-protein-synthesis-and-selw-mrna-levels-of-their-offspring
#15
Jing Gao, Wei Nie, Fenglai Wang, Yuming Guo
The present study aimed to investigate the influence of maternal selenium supplementation on the skeletal muscle development of the offspring. A total of 720 Ross 308 broiler breeders at 24-week-old were allocated into 3 treatments with 6 replicates of 40 hens each and fed with 0 mg/kg-(group Se/C), 0.5 mg/kg organic-(group Se/O), and 0.5 mg/kg inorganic-(group Se/I) selenium, respectively for 8 weeks. The male offspring from each nutritional treatment were divided and housed into 8 cages of 12 birds each and fed with a commercial diet supplemented with selenium from Na2 SeO3 at 0...
March 9, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29521487/growth-hormone-deficiency-and-pregnancy-any-role-for-substitution
#16
Greisa Vila, Anton Luger
Growth hormone (GH) is not approved for use during conception and pregnancy. Nevertheless, data from the clinical care practice reveal that most women concieve on GH replacement therapy (GHRT), and more than half continue on GHRT also during pregnancy. GH stimulates the hypothalamic-pituitary-gonadal axis at all levels, and there is evidence that GH deficiency impacts the morphology of reproductive organs, onset of puberty, ovarian function and fertility. Patients with hypopituitarism often conceive using assisted reproductive techniques and several studies support the benefit of GH supplementation for achieving fertility in women with growth hormone deficiency...
March 8, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29496417/effect-of-zinc-and-vitamin-e-supplementation-on-hormones-and-blood-biochemicals-in-peri-partum-sahiwal-cows
#17
Gulab Chandra, Anjali Aggarwal, Muneendra Kumar, Anil Kumar Singh
Thirty-two advanced pregnant multiparous Sahiwal cows were used to study the effect of additional zinc (Zn) and vitamin E (VE) supplementation on hormonal and biochemical changes. Cows were randomly assigned to four groups and fed a basal diet of compounded concentrate, berseem fodder, and wheat straw in a ratio of 60:20:20. The groups were: (1) the basal diet with no supplement (control treatment); (2) the basal diet supplemented with 60 mg/kg DM/cow daily of Zn (Zn treatment); (3) the basal diet supplemented with 1000 IU/cow daily of vitamin E (VE treatment); and (4) the basal diet supplemented with a combination of 60 mg Zn/kg DM/cow and 1000 IU vitamin E/cow/d (Zn + VE treatment)...
February 21, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29477152/effect-of-starter-diet-supplementation-on-rumen-epithelial-morphology-and-expression-of-genes-involved-in-cell-proliferation-and-metabolism-in-pre-weaned-lambs
#18
D M Sun, S Y Mao, W Y Zhu, J H Liu
Starter feeding is usually used in lamb production to improve rumen development and to facilitate the weaning process, but molecular mechanism of which is not well understood. Therefore, the objective of this study is to investigate the effect of starter feeding on the expression of ruminal epithelial genes involved in cell proliferation, apoptosis and metabolism in pre-weaned lambs. We selected eight pairs of 10-day-old lamb twins. One twin was fed ewe milk (M, n=8), while the other was fed ewe milk plus starter (M+S, n=8)...
February 26, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29473908/l-carnitine-supplementation-in-older-women-a-pilot-study-on-aging-skeletal-muscle-mass-and-function
#19
Angelika K Sawicka, Dace Hartmane, Patrycja Lipinska, Ewa Wojtowicz, Wieslawa Lysiak-Szydlowska, Robert A Olek
Skeletal muscle wasting, associated with aging, may be regulated by the inflammatory cytokines as well as by insulin-like growth factor 1 (IGF-1). l-carnitine possesses anti-inflammatory properties and increases plasma IGF-1 concentration, leading to the regulation of the genes responsible for protein catabolism and anabolism. The purpose of the present study was to evaluate the effect of a 24-week l-carnitine supplementation on serum inflammatory markers, IGF-1, body composition and skeletal muscle strength in healthy human subjects over 65 years of age...
February 23, 2018: Nutrients
https://www.readbyqxmd.com/read/29470176/association-of-insulin-like-growth-factor-1-and-igf-binding-protein-3-with-25-hydroxy-vitamin-d-in-pre-pubertal-and-adolescent-indian-girls
#20
Ramank K Marwaha, M K Garg, Sushil Gupta, Mohd Ashraf Ganie, Nandita Gupta, Archna Narang, Manoj Shukla, Preeti Arora, Annie Singh, Aditi Chadha, Ambrish Mithal
BACKGROUND: There is a high prevalence of vitamin D deficiency (VDD) in India. Molecular mechanisms suggest a strong relationship between vitamin D and growth factors. However, there is a paucity of literature with regard to a relationship between insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and vitamin D particularly in subjects with VDD. The objective of the study was to assess the relationship between growth factors and serum vitamin D-parathormone (PTH) status in school girls and study the impact of vitamin D supplementation on growth factors in pre-pubertal girls with VDD...
March 28, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
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