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https://www.readbyqxmd.com/read/29243512/the-relationship-between-hospital-construction-and-high-risk-infant-auditory-function-at-nicu-discharge-a-retrospective-descriptive-cohort-study
#1
Valerie Willis
PURPOSE: To describe the difference in auditory function at neonatal intensive care unit (NICU) discharge between high-risk infant cases exposed to hospital construction during NICU stay and those not exposed. BACKGROUND: Noise produced by routine NICU caregiving exceeds recommended intensity. As California hospitals undergo construction to meet seismic safety regulations, vulnerable neonates are potentially exposed to even higher levels of noise. Ramifications are unknown...
January 1, 2017: HERD
https://www.readbyqxmd.com/read/29242810/-her-life-rests-on-your-shoulders-doing-worry-as-emotion-work-in-the-care-of-children-with-diabetes
#2
Lisa Watt
Research on parents' caregiving experiences in the context of diabetes management have consistently shown that parents experience high levels of pediatric parenting stress, anxiety, depression, and general worry. However, how parents understand their worry is largely unexplored and little attention is paid to the work parents are already actively doing to manage their worry. Adopting Arlie Hochschild's concept of "emotion work" and Dorothy Smith's concept of "work," this article examines how parents engage in the emotion work of doing worry...
January 2017: Global Qualitative Nursing Research
https://www.readbyqxmd.com/read/29239979/monitoring-haloperidol-plasma-concentration-and-associated-adverse-events-in-critically-ill-children-with-delirium-first-results-of-a-clinical-protocol-aimed-to-monitor-efficacy-and-safety
#3
Valerie D Slooff, Desley K van den Dungen, Babette S van Beusekom, Naomi Jessurun, Erwin Ista, Dick Tibboel, Saskia N de Wildt
OBJECTIVES: As delirium in critically ill children is increasingly recognized, more children are treated with the antipsychotic drug haloperidol, while current dosing guidelines are lacking solid evidence and appear to be associated with a high risk of adverse events. We aim to report on the safety and efficacy of a recently implemented clinical dose-titration protocol with active monitoring of adverse events. DESIGN: From July 2014 until June 2015, when a potential delirium was identified by regular delirium scores and confirmed by a child psychiatrist, haloperidol was prescribed according to the Dutch Pediatric Formulary...
December 12, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29239901/prevention-of-hiv-1-transmission-through-breastfeeding-efficacy-and-safety-of-maternal-antiretroviral-therapy-versus-infant-nevirapine-prophylaxis-for-duration-of-breastfeeding-in-hiv-1-infected-women-with-high-cd4-cell-count-impaact-promise-a-randomized-open
#4
Patricia M Flynn, Taha E Taha, Mae Cababasay, Mary Glenn Fowler, Lynne M Mofenson, Maxensia Owor, Susan Fiscus, Lynda Stranix-Chibanda, Anna Coutsoudis, Devasena Gnanashanmugam, Nahida Chakhtoura, Katie McCarthy, Cornelius Mukuzunga, Bonus Makanani, Dhayendre Moodley, Teacler Nematadzira, Bangini Kusakara, Sandesh Patil, Tichaona Vhembo, Raziya Bobat, Blandina T Mmbaga, Maysseb Masenya, Mandisa Nyati, Gerhard Theron, Helen Mulenga, Kevin Butler, David E Shapiro
BACKGROUND: No randomized trial has directly compared the efficacy of prolonged infant antiretroviral prophylaxis versus maternal antiretroviral therapy (mART) for prevention of mother-to-child transmission throughout the breastfeeding period. SETTING: Fourteen sites in sub-Saharan Africa and India. METHODS: A randomized, open label strategy trial was conducted in HIV-1-infected women with CD4 counts >350 cells/mm (or >country-specific ART threshold if higher) and their breastfeeding HIV-1-uninfected newborns...
December 11, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29236411/boosting-social-and-emotional-development-in-and-out-of-school
#5
Ashley Wallace, Jennifer Palmer
(1) Illinois' state ESSA plan reflects the state’s whole-child approach, adding references to the social, emotional and behavioral needs of students, along with high expectations for student achievement. (2) Massachusetts' state ESSA plan lists supporting socialemotional learning, health and safety as among the state's core educational strategies. (3) South Carolina's ESSA plan develops a framework identifying self-direction, perseverance, global perspective and interpersonal skills to be among the characteristics that every student should have when he or she graduates from high school...
November 2017: NCSL Legisbrief
https://www.readbyqxmd.com/read/29235181/fuzheng-huayu-capsule-as-an-adjuvant-treatment-for-hbv-related-cirrhosis-a-systematic-review-and-meta-analysis
#6
REVIEW
Tao Wang, Xuelin Zhou, Honghong Liu, Jiabo Wang, Ping Zhang, Yun Zhu, Kun Li, Shizhang Wei, Haotian Li, Lifu Wang, Ruilin Wang, Yanling Zhao
Fuzheng Huayu (FZHY) capsule, a formulated traditional Chinese medicine product with 6 Chinese herbs, is widely used for HBV-related cirrhosis as an adjuvant treatment. However, the efficacy of FZHY capsule for HBV-induced cirrhosis did not be comprehensively proved by systematic analysis. Our current analysis was aimed to assess the efficacy and safety of FZHY capsule by an evidence-based method. Databases, including China National Knowledge Infrastructure, Wangfang, VIP medicine information system, Pubmed, Embase, and Cochrane Library, were searched, and the randomized controlled trials of FZHY capsule were used for the treatment of HBV-associated liver cirrhosis...
December 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29229774/ethical-considerations-for-the-design-and-implementation-of-child-injury-prevention-interventions-the-example-of-delivering-and-installing-safety-equipment-into-the-home
#7
Beatrice Scholtes, Peter Schröder-Bäck
INTRODUCTION: Public health ethics is a growing field of academic interest but ethical discussion of injury prevention seems to have received limited attention. Interventions that promise to be effective are not necessarily-without explicit justification-'good' and 'right' interventions in every sense. This paper explores public health ethics in the context of child injury prevention with the objective to initiate interdisciplinary dialogue on the ethics of child safety interventions...
December 11, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29229682/pediatric-injuries-related-to-window-blinds-shades-and-cords
#8
Bridget Onders, Eun Hye Kim, Thitphalak Chounthirath, Nichole L Hodges, Gary A Smith
OBJECTIVES: To provide an epidemiologic description of fatal and nonfatal window blind-related injuries among US children younger than 6 years of age. METHODS: Data from the Consumer Product Safety Commission's National Electronic Injury Surveillance System and In-Depth Investigation (IDI) databases were retrospectively analyzed. RESULTS: From 1990 to 2015, there were an estimated 16 827 (95% confidence interval: 13 732-19 922) window blind-related injuries among children younger than 6 years of age treated in emergency departments in the United States, corresponding to an injury rate of 2...
December 11, 2017: Pediatrics
https://www.readbyqxmd.com/read/29225673/update-on-hepatitis-c-and-implications-for-pregnancy
#9
REVIEW
Jeffrey J Post
Mother-to-child transmission of hepatitis C virus infection occurs in a significant minority of cases and the diagnosis, treatment and cure of hepatitis C virus infection with direct acting antivirals prior to pregnancy can eliminate this risk in almost all cases. Women with hepatitis C virus infection have increased risks of adverse events in pregnancy and poor perinatal outcomes for their children, although the contribution of hepatitis C virus per se is difficult to determine. Altering the mode of delivery does not reduce mother to child transmission of hepatitis C virus infection, although avoidance of fetal scalp electrodes and other potential high risk procedures is recommended during pregnancy and delivery...
December 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/29224576/using-structural-equation-modelling-to-assess-factors-influencing-children-s-growth-and-nutrition-in-rural-china
#10
Zixi Cheng, Ling Shi, Ying Li, Yan Wang, Jingxu Zhang
OBJECTIVE: Children's poor growth and nutrition status has serious consequences and therefore it is important to understand its contributing factors. DESIGN: A community-based interventional study focusing on child feeding was conducted in a rural community in China. Data from the intervention group at baseline (1-4 months of age) and follow-up visits (12 and 18 months of age) were used in the present study (n 236). A structural equation model was generated to explore the effects of family wealth, household food safety, dietary intake, diseases and other factors on the growth and nutrition of young children...
December 11, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29223767/evaluation-of-a-national-pediatric-subinternship-curriculum-implemented-through-individual-learning-plans
#11
Linda R Tewksbury, Cristina Carter, Lyuba Konopasek, Sandra M Sanguino, Janice L Hanson
OBJECTIVE: The Council on Medical Student Education in Pediatrics and Association of Pediatric Program Directors developed a Pediatric Subinternship (CAPS) Curriculum for use with an individualized learning plan (ILP). The authors determined which learning objectives (LOs) pediatric subinterns selected when provided the CAPS Curriculum, summarized students' self-reported progress, and determined feasibility of ILPs in subinternship. METHODS: Students from 10 medical schools completed a standardized ILP during pediatric subinternship...
December 6, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/29223619/differential-effects-of-hepatic-cirrhosis-on-the-intrinsic-clearances-of-sorafenib-and-imatinib-by-cyps-in-human-liver
#12
Michael Murray, Tina B Gillani, Sussan Ghassabian, Robert J Edwards, Tristan Rawling
The tyrosine kinase inhibitors sorafenib and imatinib are important in the treatment of a range of cancers but adverse effects in some patients necessitate dosage modifications. CYP3A4 has a major role in the oxidation of sorafenib to its N-oxide and N-hydroxymethyl metabolites and also acts in concert with CYP2C8 to mediate imatinib N-demethylation. CYP3A4 expression and function are impaired in patients with advanced liver disease, whereas the functions of CYP2C enzymes are relatively preserved. We evaluated the biotransformation of sorafenib and imatinib in well-characterized microsomal fractions from 17 control subjects and 19 individuals with hepatic cirrhosis of varying severity...
December 6, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29222612/how-do-parents-manage-irritability-challenging-behaviour-non-compliance-and-anxiety-in-children-with-autism-spectrum-disorders-a-meta-synthesis
#13
Elizabeth O'Nions, Francesca Happé, Kris Evers, Hannah Boonen, Ilse Noens
Although there is increasing research interest in the parenting of children with ASD, at present, little is known about everyday strategies used to manage problem behaviour. We conducted a meta-synthesis to explore what strategies parents use to manage irritability, non-compliance, challenging behaviour and anxiety in their children with ASD. Approaches included: (1) accommodating the child; (2) modifying the environment; (3) providing structure, routine and occupation; (4) supervision and monitoring; (5) managing non-compliance with everyday tasks; (6) responding to problem behaviour; (7) managing distress; (8) maintaining safety and (9) analysing and planning...
December 8, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29216612/child-safety-containers-devices-and-compounding
#14
Loyd V Allen
The U.S. Consumer Product Safety Commission has been around since it was created in 1972 through the Consumer Product Safety Act. Its purpose is to protect "against unreasonable risks of injuries associated with consumer products." Manufactured drugs must meet the standards unless specifically exempted. Dispensing and compounding pharmacists must also meet the standards. Due to a smaller market size, compliant products to meet the U.S. Consumer Product Safety Commission's standards to aid compounding pharmacists have been slow in coming...
September 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29216384/evaluating-smartphone-based-virtual-reality-to-improve-chinese-schoolchildren-s-pedestrian-safety-a-nonrandomized-trial
#15
David C Schwebel, Yue Wu, Peng Li, Joan Severson, Yefei He, Henry Xiang, Guoqing Hu
Objective: This nonrandomized trial evaluated whether classroom-based training in a smartphone-based virtual reality (VR) pedestrian environment (a) teaches schoolchildren to cross streets safely, and (b) increases their self-efficacy for street-crossing. Methods: Fifty-six children, aged 8-10 years, attending primary school in Changsha, China participated. Baseline pedestrian safety assessment occurred in the VR environment and through unobtrusive observation of a subsample crossing a street for 11 days outside school...
December 5, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29215976/supporting-obesity-prevention-in-statewide-quality-rating-and-improvement-systems-a-review-of-state-standards
#16
Nora Ann Geary, Carrie Ann Dooyema, Meredith Ann Reynolds
INTRODUCTION: A quality rating and improvement system (QRIS) is a fundamental component of most states' early care and education infrastructures. States can use a QRIS to set standards that define high-quality care and award child care providers with a quality rating designation based on how well they meet these standards. The objective of this review was to describe the extent to which states' QRIS standards include obesity prevention content. METHODS: We collected publicly available data on states' QRIS standards...
December 7, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29212386/efficacy-and-safety-of-sotagliflozin-in-treating-diabetes-type-1
#17
Marc S Rendell
INTRODUCTION: Sotagliflozin is the first dual SGLT1/SGLT2 inhibitor developed for use in diabetes. Sotagliflozin blocks SGLT2 in the kidneys and SGLT1 in the intestines resulting in reduced early phase glucose absorption and increased blood levels of GLP-1 and PYY. Urinary glucose excretion is lower than with other agents as a result of decreased glucose absorption. The primary development effort to date has been in Type 1 diabetes. AREAS COVERED: The published information on sotagliflozin is reviewed, along with the recent results of several pivotal Type 1 diabetes trials...
December 7, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29209128/role-of-combined-propofol-and-sufentanil-anesthesia-in-endoscopic-injection-sclerotherapy-for-esophageal-varices
#18
Yang Yu, Sheng-Lin Qi, Yong Zhang
AIM: To investigate the efficacy and safety of a combination of sufentanil and propofol injection in patients undergoing endoscopic injection sclerotherapy (EIS) for esophageal varices (EVs). METHODS: Patients with severe EVs who underwent EIS with sufentanil and propofol anesthesia between April 2016 and July 2016 at our hospital were reviewed. Although EIS and sequential therapy were performed under endotracheal intubation, we only evaluated the efficacy and safety of anesthesia for the first EIS procedure...
November 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29209114/combined-endovascular-brachytherapy-sorafenib-and-transarterial-chemobolization-therapy-for-hepatocellular-carcinoma-patients-with-portal-vein-tumor-thrombus
#19
Zi-Han Zhang, Qing-Xin Liu, Wen Zhang, Jing-Qin Ma, Jian-Hua Wang, Jian-Jun Luo, Ling-Xiao Liu, Zhi-Ping Yan
AIM: To evaluate the safety and efficacy of combined endovascular brachytherapy (EVBT), transarterial chemoembolization (TACE), and sorafenib to treat hepatocellular carcinoma (HCC) patients with main portal vein tumor thrombus (MPVTT). METHODS: This single-center retrospective study involved 68 patients with unresectable HCC or those who were unfit for liver transplantation and percutaneous frequency ablation according to the BCLC classification. All patients had Child-Pugh classification grade A or B, Eastern Cooperative Oncology Group (ECOG) performance status of 0-2, and MPVTT...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29208363/the-uk-paediatric-familial-hypercholesterolaemia-register-statin-related-safety-and-1-year-growth-data
#20
Steve E Humphries, Jackie Cooper, Peter Dale, Uma Ramaswami
BACKGROUND: For children with familial hypercholesterolemia (FH), UK guidelines recommend consideration of statin therapy by age 10 years and dietary and lifestyle advice to maintain an ideal body weight. OBJECTIVES: The objective of the study is to use the UK Paediatric Familial Hypercholesterolemia Register to determine: (1) the prevalence of plasma markers of liver toxicity and muscle damage in statin-treated FH children; (2) the prevalence of obesity in FH children compared to the UK general population; and (3) to compare growth rates in statin-treated and nontreated children...
November 22, 2017: Journal of Clinical Lipidology
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