keyword
https://read.qxmd.com/read/38546754/myopia-control-seeing-beyond-efficacy
#1
JOURNAL ARTICLE
Mark A Bullimore, Monica Jong, Noel A Brennan
The availability of a range of effective myopia control modalities enables the clinician to exercise judgment when discussing the treatment plan with the patient and their parents. This article outlines important considerations beyond efficacy.Clinically meaningful myopia control may be attained with some spectacle lenses, select soft contact lenses, some concentrations of atropine, and overnight orthokeratology. Given that satisfactory efficacy can be achieved with a range of modalities, other factors should be considered when deciding upon the best intervention for a given child...
March 1, 2024: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://read.qxmd.com/read/38546251/fast-track-versus-conventional-perioperative-care-protocols-in-paediatric-intestinal-stoma-closure-%C3%A2-a-randomised-study
#2
JOURNAL ARTICLE
Tanzil Farhad, Md Khurshid Alam Sarwar, Mohammad Zonaid Chowdhury, Adnan Walid, Ayesha Sadia, Tanvir Kabir Chowdhury
BACKGROUND: It is still unclear to what extent fast-track (FT) surgery is applicable in paediatric surgery. The aim of the study was to compare the outcome between FT and conventional perioperative care protocols in paediatric intestinal stoma closure to assess the safety for future application. MATERIALS AND METHODS: This study was a prospective randomised study. Twenty-six paediatric patients who underwent intestinal stoma closure from December 2019 to March 2021 were divided into two groups: group A, conventional methods and Group B FT protocol...
April 1, 2024: African Journal of Paediatric Surgery: AJPS
https://read.qxmd.com/read/38546246/parental-perspectives-regarding-circumcision-during-the-coronavirus-disease-2019-pandemic-in-indonesia
#3
JOURNAL ARTICLE
Jemmy Kurniawan, Besut Daryanto, Pradana Nurhadi, Andri Kustono
BACKGROUND: Coronavirus disease 2019 (COVID-19) pandemic has rapidly spread worldwide and affected the healthcare system, including the deferral of surgical practice. There are various reactions regarding delayed surgeries, but parental viewpoints towards circumcision remain scarce. In light of the pandemic, this study aimed to evaluate how parents feel about circumcision and the probable determining variables. MATERIALS AND METHODS: This study is a cross-sectional study based on an online questionnaire available from March to April 2022...
April 1, 2024: African Journal of Paediatric Surgery: AJPS
https://read.qxmd.com/read/38543867/factors-influencing-childhood-influenza-vaccination-a-systematic-review
#4
REVIEW
Kaiyi Han, Zhiyuan Hou, Shiyi Tu, Mengyun Liu, Tracey Chantler, Heidi Larson
Childhood influenza vaccination coverage remains low in lower/middle-income countries. This systematic review aims to identify influencing factors around childhood influenza vaccination. A systematic literature review was conducted and included empirical studies with original data that investigated factors influencing childhood influenza vaccination. We searched MEDLINE, Web of Science, EMBASE, CINAHL Plus, Global Health, PsycINFO, and two Chinese databases, China Knowledge Resource Integrated Database and Chongqing VIP, using a combination of the key terms 'childhood', 'influenza', 'vaccination', and related syntax for all peer-reviewed publications published before December 2019...
February 23, 2024: Vaccines
https://read.qxmd.com/read/38541273/voices-from-the-ground-community-perspectives-on-preventing-unintentional-child-injuries-in-low-income-settings
#5
JOURNAL ARTICLE
Prasanthi Puvanachandra, Anthony Mugeere, Charles Ssemugabo, Olive Kobusingye, Margaret Peden
Unintentional injuries significantly contribute to mortality and morbidity among children under five, with higher prevalence in low- and middle-income countries (LMICs). Deprived communities in these regions face increased injury risks, yet there is limited research on child safety tailored to their unique challenges. To address this gap, we conducted focus group discussions in rural Uganda, involving parents, village health workers, community leaders, teachers, and maids. The objective was to understand community perceptions around child safety and determine what culturally and age-appropriate solutions may work to prevent child injuries...
February 27, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38539375/suspected-simple-appendicitis-in-children-should-we-use-a-nonoperative-antibiotic-free-approach-an-observational-study
#6
JOURNAL ARTICLE
Patricia Reis Wolfertstetter, John Blanford Ebert, Judith Barop, Markus Denzinger, Michael Kertai, Hans J Schlitt, Christian Knorr
BACKGROUND: Simple appendicitis may be self-limiting or require antibiotic treatment or appendectomy. The aim of this study was to assess the feasibility and safety of a nonoperative, antibiotic-free approach for suspected simple appendicitis in children. METHODS: This single-center, retrospective study included patients (0-17 years old) who were hospitalized at the pediatric surgery department due to suspected appendicitis between 2011 and 2012. Data from patients who primarily underwent appendectomy were used as controls...
March 13, 2024: Children
https://read.qxmd.com/read/38539331/proton-pump-inhibitors-in-pediatric-gastroesophageal-reflux-disease-a-systematic-review-of-randomized-controlled-trials
#7
REVIEW
Sara María Fernández-González, Ana Moreno-Álvarez, Alfonso Solar-Boga
This systematic review was conducted with the objective of understanding the efficacy and safety of proton pump inhibitors (PPIs) in the pediatric population. We used PubMed to identify randomized controlled trials (RCTs) published between 1 June 2010 and 30 June 2023, performed in patients from birth to 18 years old with gastroesophageal reflux disease (GERD) who received treatment with any PPI. This literature search yielded 76 articles and 13 of these met the inclusion criteria. For infants, PPIs were equal to placebos in reducing GERD symptoms in four articles...
March 1, 2024: Children
https://read.qxmd.com/read/38539311/antimicrobial-stewardship-in-pediatric-emergency-medicine-a-narrative-exploration-of-antibiotic-overprescribing-stewardship-interventions-and-performance-metrics
#8
REVIEW
Kevin Meesters, Danilo Buonsenso
Antibiotic overprescribing is prevalent in pediatric emergency medicine, influenced by clinician-caregiver dynamics and diagnostic uncertainties, and poses substantial risks such as increasing antibacterial resistance, adverse drug reactions, and increased healthcare expenditures. While antimicrobial stewardship programs have proven effective in optimizing antibiotic use within inpatient healthcare settings, their implementation in pediatric emergency medicine presents specific challenges. Existing biomarkers like white blood cell count, C-reactive protein, procalcitonin, and presepsin have limitations in their ability to distinguish (serious) bacterial infections from other etiologies of fever...
February 23, 2024: Children
https://read.qxmd.com/read/38535409/a-phase-three-study-of-the-safety-and-immunogenicity-of-a-four-dose-series-of-20-valent-pneumococcal-conjugate-vaccine-in-healthy-infants
#9
JOURNAL ARTICLE
Shelly Senders, Nicola P Klein, Noor Tamimi, Allison Thompson, Gary Baugher, James Trammel, Yahong Peng, Peter Giardina, Ingrid L Scully, Michael Pride, Kimberly J Center, William C Gruber, Daniel A Scott, Wendy Watson
BACKGROUND: The 20-valent pneumococcal conjugate vaccine (PCV20) was developed to extend pneumococcal disease protection beyond 13-valent PCV (PCV13). METHODS: This phase 3, double-blind study conducted in the United States/Puerto Rico evaluated PCV20 safety and immunogenicity. Healthy infants were randomized to receive a 4-dose series of PCV20 or PCV13 at 2, 4, 6 and 12-15 months old. Objectives included demonstrating noninferiority (NI) of PCV20 to PCV13 immunoglobulin G (IgG) geometric mean concentrations after doses 3 and 4 and percentages of participants with predefined IgG concentrations after dose 3, with 7 additional PCV20 serotypes compared with the lowest result among vaccine serotypes in the PCV13 group...
March 26, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38533796/digital-based-interventions-for-complex-post-traumatic-stress-disorder-a-systematic-literature-review
#10
REVIEW
Meg Blackie, Kathleen De Boer, Liz Seabrook, Glen Bates, Maja Nedeljkovic
Research has shown that complex post-traumatic stress disorder (cPTSD) differs from post-traumatic stress disorder (PTSD) on core symptoms relating to the individual's sense of self, and this has driven the need for treatment approaches to address these specific features of cPTSD. The COVID-19 pandemic has led to the increased use of digital-based interventions (DBIs) to treat mental illnesses, including trauma-related disorders. However, while evidence for the use of DBIs for PTSD has previously been synthesized, the current review is the first synthesis of research on the use of DBIs for cPTSD...
March 27, 2024: Trauma, Violence & Abuse
https://read.qxmd.com/read/38533633/clinical-trial-randomized-controlled-trial-of-linaclotide-in-children-aged-6-17-years-with-functional-constipation
#11
JOURNAL ARTICLE
Carlo Di Lorenzo, Samuel Nurko, Jeffrey S Hyams, Gerardo Rodriguez-Araujo, Cristina Almansa, Valentina Shakhnovich, Miguel Saps, Michael Simon
OBJECTIVES: Linaclotide, a guanylate cyclase-C agonist, was recently approved in the United States for treatment of children 6-17 years old with functional constipation (FC). This study evaluated the safety and efficacy of several linaclotide doses in children 6-17 years old with FC. METHODS: In this multicenter, randomized, double-blind, placebo-controlled phase 2 study, 173 children with FC (based on Rome III criteria) were randomized to once-daily linaclotide (A: 9 or 18 μg, B: 18 or 36 μg, or C: 36 or 72 μg) or placebo in a 1:1:1:1 ratio for 6- to 11-year-olds (dosage determined by weight: 18 to <35 or ≥35 kg) and linaclotide (18, 36, 72, or 145 μg) or placebo in a 1:1:1:1:1 ratio for 12- to 17-year-olds...
March 27, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38532901/a-6-year-old-with-childhood-absence-epilepsy-and-motor-hyperactivity
#12
JOURNAL ARTICLE
Stéphane Auvin
A case study of a child with childhood absence epilepsy and hyperactivity introduces the discussion around the psychiatric diagnosis, differential considerations, and pharmacologic treatment options for ADHD/hyperactivity in children with epilepsy. Most of the time, ADHD in children with epilepsy is an inattentive form. The assessment emphasizes the need to differentiate ADHD symptoms from other psychiatric comorbidities. This is also crucial to evaluate when symptoms emerged, their impact on daily life, and if it could be a potential medication side effect...
2024: Epilepsy & behavior reports
https://read.qxmd.com/read/38532338/carbon-ion-radiotherapy-for-hepatocellular-carcinoma-with-major-vascular-invasion-a-retrospective-cohort-study
#13
JOURNAL ARTICLE
Takashi Kaneko, Hirokazu Makishima, Masaru Wakatsuki, Yuichi Hiroshima, Toshiaki Matsui, Shigeo Yasuda, Naomi Nagatake Okada, Kenji Nemoto, Hiroshi Tsuji, Shigeru Yamada, Masaru Miyazaki
BACKGROUND: Macroscopic vascular invasion (MVI) significantly impacts survival in patients with hepatocellular carcinoma (HCC), warranting systemic therapy over locoregional therapy. Despite novel approaches, HCC with MVI has a poor prognosis compared to early-to intermediate-stage HCC. This study aimed to evaluate the safety and efficacy of carbon-ion radiotherapy (C-ion RT) for HCC characterized by MVI. METHODS: This retrospective cohort study evaluated HCC patients with MVI treated using C-ion RT with a dose of 45...
March 26, 2024: BMC Cancer
https://read.qxmd.com/read/38530388/-position-paper-on-working-in-the-intensive-care-unit-during-pregnancy-divi-recommendations-for-improving-the-situation-of-pregnant-employees-in-the-icu
#14
REVIEW
Celina Cornelius, Teresa Deffner, Aileen Hill, Christina Rohlfes, Bernd Ellner, Silke Klarmann, Sabine Riedel, Sabrina Pelz, Sabrina Kopp, Laura Borgstedt, Diana Freund, Andreas Schöpfel, Patrick Meybohm, Felix Walcher, Thorsten Brenner, Stefanie Klenke
The Maternity Protection Act is intended to protect the mother and the child from hazards, excessive demands and damage to health in the workplace, and from financial disadvantages and loss of employment. However, the objectives defined by the Maternity Protection Act-the safety and health of the pregnant employee on the one hand and the prevention of disadvantages in working life on the other-are not yet adequately achieved in the intensive care unit (ICU). Implementation of the Maternity Protection Act to the benefit of all involved parties should also be promoted in the specialist areas represented by the DIVI, in particular the work of pregnant physicians and nursing staff and other working specialists (respiratory therapists, physiotherapists, speech therapists, psychotherapists, and social workers) in the ICU...
March 26, 2024: Anaesthesiologie
https://read.qxmd.com/read/38530386/-position-paper-on-working-in-the-intensive-care-unit-during-pregnancy-divi-recommendations-for-improving-the-situation-of-pregnant-employees-in-the-icu
#15
REVIEW
Celina Cornelius, Teresa Deffner, Aileen Hill, Christina Rohlfes, Bernd Ellner, Silke Klarmann, Sabine Riedel, Sabrina Pelz, Sabrina Kopp, Laura Borgstedt, Diana Freund, Andreas Schöpfel, Patrick Meybohm, Felix Walcher, Thorsten Brenner, Stefanie Klenke
The Maternity Protection Act is intended to protect the mother and the child from hazards, excessive demands and damage to health in the workplace, and from financial disadvantages and loss of employment. However, the objectives defined by the Maternity Protection Act-the safety and health of the pregnant employee on the one hand and the prevention of disadvantages in working life on the other-are not yet adequately achieved in the intensive care unit (ICU). Implementation of the Maternity Protection Act to the benefit of all involved parties should also be promoted in the specialist areas represented by the DIVI, in particular the work of pregnant physicians and nursing staff and other working specialists (respiratory therapists, physiotherapists, speech therapists, psychotherapists, and social workers) in the ICU...
March 26, 2024: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://read.qxmd.com/read/38529710/sq-sublingual-immunotherapy-tablets-for-children-with-allergic-rhinitis-a-review-of-phase-three-trials
#16
REVIEW
Péter Csonka, Eckard Hamelmann, Mirjana Turkalj, Graham Roberts, Douglas P Mack
AIM: To provide paediatricians with a summary of efficacy and safety of SQ sublingual immunotherapy (SLIT) tablets from phase three, randomised, double-blind, placebo-controlled trials in children and adolescents with allergic rhinitis or rhinoconjunctivitis, with and without asthma. METHODS: PubMed searches were conducted and unpublished data were included if necessary. RESULTS: Of the 93 publications, 12 were identified reporting 10 trials...
March 26, 2024: Acta Paediatrica
https://read.qxmd.com/read/38529431/knowledge-and-attitude-toward-child-safety-seat-use-in-saudi-arabia-a-cross-sectional-study
#17
JOURNAL ARTICLE
Hanan Mashi, Esra Alamri, Shahd Alotaibi, Jamal A Omer
Background Car safety seats (CSS) are a well-established strategy to reduce injuries and fatalities among children involved in road traffic accidents. However, the use of CSS is generally low globally due to limited knowledge of its benefits. This study assessed parents' knowledge and attitudes toward CSS in Saudi Arabia. Methods This cross-sectional study used an online self-administered survey distributed among residents in different regions of Saudi Arabia to assess their knowledge and attitude toward CSS...
February 2024: Curēus
https://read.qxmd.com/read/38527824/uptake-of-a-multilingual-intervention-to-promote-toothbrushing-in-a-safety-net-health-care-system
#18
JOURNAL ARTICLE
John Ahern, Brandon Pleman, Nicole O'Connor, Hugh Silk
No abstract text is available yet for this article.
2024: Annals of Family Medicine
https://read.qxmd.com/read/38524859/characteristics-and-influencing-factors-of-post-traumatic-growth-a-cross-sectional-study-of-psychiatric-nurses-suffering-from-workplace-violence-in-guangdong-china
#19
JOURNAL ARTICLE
Wen Wang, Junrong Ye, Yanheng Wei, Lexin Yuan, Jialan Wu, Zhichun Xia, Jiawei Huang, Haoyun Wang, Zezhi Li, Jianxiong Guo, Aixiang Xiao
BACKGROUND: Workplace violence (WPV) had become an important issue that endangered the occupational safety of psychiatric nurses. A growing number of studies showed positive post-traumatic growth (PTG) resulting from coping with trauma. OBJECTIVE: To investigate the characteristics of PTG in psychiatric nurses who experienced violence in the workplace and analyze its influencing factors. METHODS: A total of 1202 psychiatric nurses participated in the study...
2024: Journal of Multidisciplinary Healthcare
https://read.qxmd.com/read/38523492/effect-of-hepatic-impairment-on-the-pharmacokinetics-of-fenfluramine-and-norfenfluramine
#20
JOURNAL ARTICLE
Aravind Mittur, Ryan Madanick, Melanie Langlois, Brooks Boyd
Fenfluramine (Fintepla® ) is approved for the treatment of seizures associated with the rare epileptic encephalopathies Dravet syndrome and Lennox-Gastaut syndrome. Fenfluramine is extensively metabolized; thus, patients with hepatic impairment (HI) might experience changes in exposure to fenfluramine or its metabolites. In this phase 1 study, we investigated the pharmacokinetics (PK) and safety of a single oral dose of 0.35 mg/kg fenfluramine in subjects with mild (n = 8), moderate (n = 8), or severe (n = 7) HI (Child-Pugh A/B/C, respectively) and healthy control subjects (n = 22) matched for sex, age, and BMI...
March 25, 2024: Journal of Clinical Pharmacology
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