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https://www.readbyqxmd.com/read/29457204/prevention-and-management-of-childhood-obesity
#1
Aashima Dabas, Anju Seth
Childhood obesity has been recognized as a global pandemic. Preventive strategies have proven to be the most effective public health intervention in curbing this pandemic. A multi-component approach involving dietary modification and advocacy for a healthy lifestyle comprising of regular physical activity, minimizing screen time and behavioral interventions have been found beneficial in preventing obesity. A life-cycle approach has been recommended where preventive interventions go as far back as affecting maternal, fetal and early childhood nutrition and lifestyle...
February 19, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29454255/effects-of-adjunctive-eslicarbazepine-acetate-on-neurocognitive-functioning-in-children-with-refractory-focal-onset-seizures
#2
Sergiusz Jóźwiak, P Veggiotti, J Moreira, H Gama, F Rocha, P Soares-da-Silva
PURPOSE: This was a phase-II, randomized, double-blind (DB), placebo-controlled study aimed to evaluate neurocognitive effects of eslicarbazepine acetate (ESL) as adjunctive therapy in pediatric patients with refractory focal-onset seizures (FOS). METHODS: Children (6-16years old) with FOS were randomized (2:1) to ESL or placebo. Treatment started at 10mg/kg/day, was up-titrated up to 30mg/kg/day (target dose), and maintained for 8weeks, followed by one-year open-label follow-up...
February 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29453272/building-the-child-safety-collaborative-innovation-and-improvement-network-how-does-it-work-and-what-is-it-achieving
#3
Jennifer B Leonardo, Rebecca S Spicer, Maria Katradis, Jennifer Allison, Rebekah Thomas
OBJECTIVE: This study investigated whether the Child Safety Collaborative Innovation and Improvement Network (CS CoIIN) framework could be applied in the field of injury and violence prevention to reduce fatalities, hospitalizations and emergency department visits among 0-19 year olds. SAMPLE: Twenty-one states/jurisdictions were accepted into cohort 1 of the CS CoIIN, and 14 were engaged from March 2016 through April 2017. A quality improvement framework was used to test, implement and spread evidence-based change ideas (strategies and programs) in child passenger safety, falls prevention, interpersonal violence prevention, suicide and self-harm prevention and teen driver safety...
February 16, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29449180/effectiveness-of-systemic-family-therapy-versus-treatment-as-usual-for-young-people-after-self-harm-a-pragmatic-phase-3-multicentre-randomised-controlled-trial
#4
David J Cottrell, Alexandra Wright-Hughes, Michelle Collinson, Paula Boston, Ivan Eisler, Sarah Fortune, Elizabeth H Graham, Jonathon Green, Allan O House, Michael Kerfoot, David W Owens, Eirini-Christina Saloniki, Mima Simic, Fiona Lambert, Justine Rothwell, Sandy Tubeuf, Amanda J Farrin
BACKGROUND: Self-harm in adolescents is common and repetition occurs in a high proportion of these cases. Scarce evidence exists for effectiveness of interventions to reduce self-harm. METHODS: This pragmatic, multicentre, randomised, controlled trial of family therapy versus treatment as usual was done at 40 UK Child and Adolescent Mental Health Services (CAMHS) centres. We recruited young people aged 11-17 years who had self-harmed at least twice and presented to CAMHS after self-harm...
February 12, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29444116/field-evaluation-of-the-safety-acceptability-and-feasibility-of-early-infant-male-circumcision-using-the-accucirc-device
#5
Robert C Bailey, Irene Nyaboke, Mary Ellen Mackesy-Amiti, Erick Okello, Valentine Pengo, Betha Ochomo, Mary Emmaculate Auma, Simon Were, Stella Ojuok, Evelyne Adoyo, Mildred Adhiambo, Marisa R Young, Rebeca M Plank, Fredrick O Otieno
BACKGROUND: As countries scale up adult voluntary medical male circumcision (VMMC) for HIV prevention, they are looking ahead to long term sustainable strategies, including introduction of early infant male circumcision (EIMC). Although a number of devices for EIMC are prequalified by the World Health Organization, evaluation of additional devices can provide policy-makers and clinicians the information required to make informed decisions. We undertook a field evaluation of the safety and acceptability of the AccuCirc device in Kisumu County, Kenya...
2018: PloS One
https://www.readbyqxmd.com/read/29443456/pharmacokinetics-and-safety-of-bazedoxifene-in-hepatically-impaired-and-healthy-postmenopausal-women
#6
William McKeand, Susan Baird-Bellaire, James Ermer, Alain Patat
Bazedoxifene, a selective estrogen receptor modulator with proestrogenic effects on bone and lipid metabolism and antiestrogenic effects on the breast and endometrium, is a treatment option for osteoporosis in postmenopausal women. It is extensively metabolized by the liver; therefore, a decrease in liver function was expected to decrease bazedoxifene clearance. This single-dose, open-label, inpatient/outpatient, nonrandomized study assessed the pharmacokinetics of bazedoxifene 20 mg in 18 postmenopausal women with hepatic impairment and 18 matched healthy postmenopausal women...
February 14, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29436037/parental-use-of-sun-protection-for-their-children-does-skin-color-matter
#7
Marcus G Tan, Shudeshna Nag, Miriam Weinstein
BACKGROUND/OBJECTIVES: Excessive sun exposure during childhood is a risk factor for skin cancer. This study aimed to compare the frequency of ideal sun protection use between parents with lighter- and darker-skinned children and explore their attitudes and beliefs on sun safety and their choice of sun protection. METHODS: Parents of children aged 6 months to 6 years completed self-administered questionnaires about sun protection practices for their children. Parents assessed their child's Fitzpatrick phototype and were divided into lighter- (Fitzpatrick phototype I-III) and darker-skinned (Fitzpatrick phototype IV-VI) groups...
February 13, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29435699/psychosocial-benefits-of-fertility-preservation-for-young-cancer-patients
#8
Juliana Assi, Juliana Santos, Tatiana Bonetti, Paulo C Serafini, Eduardo L A Motta, Mauricio Barbour Chehin
PURPOSE: The risk of ovarian failure after radiotherapy and/or chemotherapy is a concern among oncologic women. There is no doubt regarding the psycho-emotional benefits of fertility preservation (FP) after a cancer diagnosis because concerns about biological conception are a source of anxiety and can even affect the patient's cancer recovery. The aim of this study was to evaluate oncology patients' feelings, concerns, and life quality impacts related to FP. METHODS: This qualitative cross-sectional study was based on a questionnaire administered to a selected group of women diagnosed with cancer who underwent FP...
February 12, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29432338/patient-reported-experience-in-the-pediatric-emergency-department-what-matters-most
#9
Mher Barbarian, Andrea Bishop, Patricia Alfaro, Alain Biron, Daniel Adam Brody, Gabrielle Cunningham-Allard, Alexander Sasha Dubrovsky
INTRODUCTION: Although the Child Hospital Consumer Assessment of Healthcare Providers and Systems is a validated tool for the inpatient experience, it may not address features unique to the pediatric emergency department (PED). There is currently no publicly available validated patient-reported experience survey for the PED, and what matters most in this setting remains unknown. METHODS: Twelve semistructured interviews were conducted with a convenience sample of parents of children younger than 14 years at a Canadian PED...
February 9, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29431477/evaluation-of-give-kids-a-boost-a-school-based-program-to-increase-booster-seat-use-among-urban-children-in-economically-disadvantaged-areas
#10
Merissa A Yellman, Marissa A Rodriguez, Maria Isabel Colunga, Mary A McCoy, Shelli Stephens-Stidham, L Steven Brown, Gregory R Istre
Objective This study evaluated the effectiveness of a series of one-year, multi-faceted, school-based programs aimed at increasing booster seat use among urban children 4-7 years of age in economically-disadvantaged areas. Methods During four consecutive school years, 2011-2015, the Give Kids a Boost (GKB) program was implemented in a total of 8 schools with similar demographics in Dallas County. Observational surveys were conducted at project schools before project implementation (P0), 1-4 weeks after the completion of project implementation (P1), and 4-5 months later (P2)...
February 12, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29431187/migration-factors-in-west-african-immigrant-parents-perceptions-of-their-children-s-neighborhood-safety
#11
Andrew Rasmussen, Aïcha Cissé, Ying Han, Sonia Roubeni
Immigrants make up large proportions of many low-income neighborhoods, but have been largely ignored in the neighborhood safety literature. We examined perceived safety's association with migration using a six-item, child-specific measure of parents' perceptions of school-aged (5-12 years of age) children's safety in a sample of 93 West African immigrant parents in New York City. Aims of the study were (a) to identify pre-migration correlates (e.g., trauma in home countries), (b) to identify migration-related correlates (e...
February 12, 2018: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29431008/gasoline-related-injuries-and-fatalities-in-the-united-states-1995-2014
#12
Dorothy A Drago
This descriptive study examines twenty years of gasoline-related fatalities and emergency department treated injuries in the United States, based on data from the US Consumer Product Safety Commission. Thermal burns consistently accounted for the majority (56%) of gasoline-related injuries and for most (82%) gasoline-related deaths, and were commonly (57-71%) associated with the use of gasoline as an accelerant. Poisoning accounted for 13% of injuries and 17% of deaths. The primary poisoning injury pattern was ingestion; the primary fatality pattern was inhalation, with about half of those associated with deliberate abuse...
February 12, 2018: International Journal of Injury Control and Safety Promotion
https://www.readbyqxmd.com/read/29426324/role-of-parental-and-environmental-characteristics-in-toddlers-physical-activity-and-screen-time-bayesian-analysis-of-structural-equation-models
#13
Eun-Young Lee, Kylie D Hesketh, Ryan E Rhodes, Christina M Rinaldi, John C Spence, Valerie Carson
BACKGROUND: Guided by the Socialization Model of Child Behavior (SMCB), this cross-sectional study examined direct and indirect associations of parental cognitions and behavior, the home and neighborhood environment, and toddlers' personal attributes with toddlers' physical activity and screen time. METHODS: Participants included 193 toddlers (1.6 ± 0.2 years) from the Parents' Role in Establishing healthy Physical activity and Sedentary behavior habits (PREPS) project...
February 9, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29425519/an-adverse-event-analysis-inadvertent-exsanguination-following-left-ventricular-assist-device-implantation-in-a-child
#14
REVIEW
Alex Robertson, Tain-Yen Hsia
Neurologic deficit subsequent to cardiac surgery remains a cause of postoperative morbidity and mortality. Although myriad risk factors for postoperative cognitive decline have been identified, their individual influence remains undefined. Although less emphasis is now placed on the heart lung machine as the major source of postoperative cognitive decline, the conduct of cardiopulmonary bypass and, in particular, the management of the bypass circuit remain key to patient safety. We present a case of inadvertent intraoperative exsanguination of a patient following open heart surgery for implantation of a left ventricular assist device...
March 2018: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
https://www.readbyqxmd.com/read/29425111/the-safety-of-lipistart-a-medium-chain-triglyceride-based-formula-in-the-dietary-treatment-of-long-chain-fatty-acid-disorders-a-phase-i-study
#15
Anita MacDonald, Rachel Webster, Matthew Whitlock, Adam Gerrard, Anne Daly, Mary Anne Preece, Sharon Evans, Catherine Ashmore, Anupam Chakrapani, Suresh Vijay, Saikat Santra
BACKGROUND: Children with long-chain fatty acid β-oxidation disorders (LCFAOD) presenting with clinical symptoms are treated with a specialist infant formula, with medium chain triglyceride (MCT) mainly replacing long chain triglyceride (LCT). It is essential that the safety and efficacy of any new specialist formula designed for LCFAOD be tested in infants and children. METHODS: In an open-label, 21-day, phase I trial, we studied the safety of a new MCT-based formula (feed 1) in six well-controlled children (three male), aged 7-13 years (median 9 years) with LCFAOD (very long chain acyl CoA dehydrogenase deficiency [VLCADD], n=2; long chain 3-hydroxyacyl CoA dehydrogenase deficiency [LCHADD], n=2; carnitine acyl carnitine translocase deficiency [CACTD], n=2)...
February 9, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29423260/a-heel-strike-real-time-auditory-feedback-device-to-promote-motor-learning-in-children-who-have-cerebral-palsy-a-pilot-study-to-test-device-accuracy-and-feasibility-to-use-a-music-and-dance-based-learning-paradigm
#16
Jaswandi Tushar Pitale, John H Bolte
Background: Cerebral palsy (CP) is a developmental disorder of movement and posture that occurs due to damage to the developing nervous system. As part of therapy, wearable sensors that trigger interactive feedback may provide multi-sensory guidance and motivation. A prototype of a heel-strike real-time feedback system has been developed which records the number of heel strikes during gait and indicates successful heel contact through real-time auditory feedback. The first aim of this feasibility study was to test the prototype accuracy...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29421475/safety-trust-and-disclosure-a-qualitative-examination-of-violence-against-refugee-adolescents-in-kiziba-camp-rwanda
#17
Laura Gauer Bermudez, Lauren Parks, Sarah R Meyer, Liberata Muhorakeye, Lindsay Stark
Refugee adolescents face increased vulnerability to child protection risks including abuse, neglect, violence, and exploitation. The aim of this qualitative study was to examine the nature of violence against adolescents in Kiziba Camp, Rwanda, using an ecological framework to analyze the factors that influence protection risks and abuse disclosure across multiple system levels. In order to understand these issues more comprehensively, a transgenerational inquiry sought perceptions from both adolescents and their caregivers...
January 26, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29421474/improving-recruitment-to-clinical-trials-during-pregnancy-a-mixed-methods-investigation
#18
Sofia Strömmer, Wendy Lawrence, Taylor Rose, Christina Vogel, Daniella Watson, Joanne N Botell, Nicholas C Harvey, Cyrus Cooper, Hazel Inskip, Janis Baird, Mary Barker
OBJECTIVE: To identify reasons underlying women's refusal to participate in a pregnancy trial and to identify ways of increasing recruitment. DESIGN: Mixed methods study using a questionnaire and qualitative interviews. SAMPLE: A questionnaire asking them to indicate reasons for their decision was completed by 296 pregnant women who declined to participate in one of two trials of nutritional supplementation in a large teaching hospital in southern England...
January 17, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29420549/contexts-of-vulnerability-and-the-acceptability-of-new-biomedical-hiv-prevention-technologies-among-key-populations-in-south-africa-a-qualitative-study
#19
Millicent Atujuna, Peter A Newman, Melissa Wallace, Megan Eluhu, Clara Rubincam, Ben Brown, Linda-Gail Bekker
BACKGROUND: New biomedical prevention technologies (NPTs) may contribute to substantially reducing incident HIV infections globally. We explored acceptability and preferences for NPTs among key and other vulnerable populations in two South African townships. METHODS: We conducted six focus groups and 12 in-depth interviews with adolescents, and adult heterosexual men, women, and men who have sex with men (MSM) (n = 48), and eight in-depth interviews with key informant healthcare workers...
2018: PloS One
https://www.readbyqxmd.com/read/29417302/balancing-animal-welfare-and-assisted-reproduction-ethics-of-preclinical-animal-research-for-testing-new-reproductive-technologies
#20
Verna Jans, Wybo Dondorp, Ellen Goossens, Heidi Mertes, Guido Pennings, Guido de Wert
In the field of medically assisted reproduction (MAR), there is a growing emphasis on the importance of introducing new assisted reproductive technologies (ARTs) only after thorough preclinical safety research, including the use of animal models. At the same time, there is international support for the three R's (replace, reduce, refine), and the European Union even aims at the full replacement of animals for research. The apparent tension between these two trends underlines the urgency of an explicit justification of the use of animals for the development and preclinical testing of new ARTs...
February 7, 2018: Medicine, Health Care, and Philosophy
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