Mariangela Tamburello, Andrea Abate, Elisa Rossini, Ram Manohar Basnet, Daniela Zizioli, Deborah Cosentini, Constanze Hantel, Marta Laganà, Guido Alberto Massimo Tiberio, Salvatore Grisanti, Maurizio Memo, Alfredo Berruti, Sandra Sigala
BACKGROUND: Adrenocortical cancer (ACC) is a rare malignancy with a dismal prognosis. The treatment includes mitotane and EDP chemotherapy (etoposide, doxorubicin, and cisplatin). However, new therapeutic approaches for advanced ACC are needed, particularly targeting the metastatic process. Here, we deepen the role of progesterone as a new potential drug for ACC, in line with its antitumoral effect in other cancers. METHODS: NCI-H295R, MUC-1, and TVBF-7 cell lines were used and xenografted in zebrafish embryos...
April 6, 2023: International Journal of Molecular Sciences