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https://www.readbyqxmd.com/read/27870712/a-phase-2-randomized-open-label-study-of-irosustat-versus-megestrol-acetate-in-advanced-endometrial-cancer
#1
Patricia Pautier, Ignace Vergote, Florence Joly, Bohuslav Melichar, Elzbieta Kutarska, Geoffrey Hall, Anna Lisyanskaya, Nicholas Reed, Ana Oaknin, Valerijus Ostapenko, Zanete Zvirbule, Eric Chetaille, Agnès Geniaux, Muhammad Shoaib, John A Green
OBJECTIVE: Advanced/metastatic or recurrent endometrial cancer has a poor prognosis. Malignant endometrial tissue has high steroid sulphatase (STS) activity. The aim of this study was to evaluate STS as a therapeutic target in patients with endometrial cancer. METHODS: This was a phase 2, multicenter, international, open-label, randomized (1:1), 2-arm study of the STS inhibitor oral irosustat 40 mg/d versus oral megestrol acetate 160 mg/d in women with advanced/metastatic or recurrent estrogen receptor-positive endometrial cancer...
November 17, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27858548/cancer-cachexia-beyond-weight-loss
#2
Andrew R Bruggeman, Arif H Kamal, Thomas W LeBlanc, Joseph D Ma, Vickie E Baracos, Eric J Roeland
Cancer cachexia is a multifactorial syndrome characterized by skeletal muscle loss leading to progressive functional impairment. Despite the ubiquity of cachexia in clinical practice, prevention, early identification, and intervention remain challenging. The impact of cancer cachexia on quality of life, treatment-related toxicity, physical function, and mortality are well established; however, establishing a clinically meaningful definition has proven challenging because of the focus on weight loss alone. Attempts to more comprehensively define cachexia through body composition, physical functioning, and molecular biomarkers, while promising, are yet to be routinely incorporated into clinical practice...
November 2016: Journal of Oncology Practice
https://www.readbyqxmd.com/read/27829826/evaluate-the-effectiveness-of-conservative-treatment-for-menorrhagia-in-women-who-were-admitted-to-the-shahid-sadoughi-hospital-of-yazd-iran-in-2014-2015
#3
M Karimi-Zarchi, M Zaid Abadinezhad, B Bonyadpour, S Kabyrpour-Ashkezar, A M Abhaji
BACKGROUND AND AIM: Abnormal uterine bleeding is one of the most common debilitating menstrual problems. The first therapeutic strategy for abnormal uterine bleeding is drug treatment. This study was, therefore, designed to determine the efficacy of megestrol, medroxyprogesterone, GnRh agonist, Levonorgestrol IUD and endometrial ablation on bleeding and also to evaluate the side effects of each methods in patients with menorrhagia who were admitted to the Shahid Sadoughi clinic of Yazd University of Medical Sciences...
September 2016: International Journal of Biomedical Science: IJBS
https://www.readbyqxmd.com/read/27690687/a-comparison-between-the-effects-of-metformin-and-megestrol-on-simple-endometrial-hyperplasia
#4
Fatemeh Sharifzadeh, Soheila Aminimoghaddam, Maryam Kashanian, Masoomeh Fazaeli, Narges Sheikhansari
INTRODUCTION: Endometrial hyperplasia is one of the most serious causes of severe abnormal bleeding and also can be a precursor of endometrial carcinoma. OBJECTIVE: The purpose of the present study was to compare the effects of metformin and megestrol on the endometrial hyperplasia. METHODS: The study was performed as a randomized clinical trial on 42 cases of histopathologically confirmed simple endometrial hyperplasia without atypia. The eligible women were randomly assigned into two groups...
September 30, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27670256/fertility-preserving-treatment-with-hysteroscopic-resection-followed-by-progestin-therapy-in-young-women-with-early-endometrial-cancer
#5
Francesca Falcone, Giuseppe Laurelli, Simona Losito, Marilena Di Napoli, Vincenza Granata, Stefano Greggi
OBJECTIVE: To report our 15-year institutional experience of fertility-sparing treatment in young patients with early endometrial cancer (EC) treated by combined hysteroscopic resection and progestin therapy. METHODS: Twenty-eight patients (stage IA, G1 and 2 endometrioid EC) wishing to preserve their fertility were enrolled into this prospective study. Hysteroscopic resection was used to resect the tumor, endometrium adjacent to the tumor and myometrium underlying the tumor...
August 8, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27639080/quantitative-assessment-of-food-effect-on-the-pharmacokinetics-of-nano-crystallized-megestrol-acetate
#6
Jinju Guk, Hankil Son, Dong Woo Chae, Kyungsoo Park
Megestrol acetate, an appetite stimulant with low bioavailability, shows increased bioavailability when taken together with food. However, the pharmacokinetic characteristics of megestrol acetate and its relation with food are not well understood. This study aimed to investigate the food effect on the pharmacokinetics (PK) of the recently developed nano-crystallized megestrol acetate (NCMA), using a model-based approach. Data were obtained from an NCMA PK study consisting of a single dose in fasting (39 individuals) and fed conditions (40 individuals)...
September 17, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27343306/clinicopathologic-characteristics-and-treatment-features-of-women-with-the-incidental-diagnosis-of-endometrial-adenocarcinoma-during-infertility-follow-up-in-ankara-turkey
#7
Tayfun Gungor, Nilufer Cetinkaya, Hakan Yalcin, Sema Zergeroglu, Salim Erkaya
OBJECTIVE: The aim of this study was to investigate the clinical and laboratory features of patients with the incidental diagnosis of endometrial adenocarcinoma (EC) during infertility work-up, with special attention given to treatment approaches, recurrence rate, and fertility outcome. MATERIAL AND METHODS: The medical records of 577 patients who were diagnosed with EC and treated between 2007 and 2013 were included in the study. Out of 577 EC patients, 5.1% (n = 30) were ≤ 40 years of age...
June 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27239419/megestrol-acetate-improves-cardiac-function-in-a-model-of-cancer-cachexia-induced-cardiomyopathy-by-autophagic-modulation
#8
Vincenzo Musolino, Sandra Palus, Anika Tschirner, Cathleen Drescher, Micaela Gliozzi, Cristina Carresi, Cristiana Vitale, Carolina Muscoli, Wolfram Doehner, Stephan von Haehling, Stefan D Anker, Vincenzo Mollace, Jochen Springer
BACKGROUND: Cachexia is a complex metabolic syndrome associated with cancer. One of the features of cachexia is the loss of muscle mass, characterized by an imbalance between protein synthesis and protein degradation. Muscle atrophy is caused by the hyperactivation of some of the main cellular catabolic pathways, including autophagy. Cachexia also affects the cardiac muscle. As a consequence of the atrophy of the heart, cardiac function is impaired and mortality is increased. Anti-cachectic therapy in patients with cancer cachexia is so far limited to nutritional support and anabolic steroids...
December 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27218795/pharmacy-report-megestrol-acetate-induced-adrenal-insufficiency
#9
Sowmya Nanjappa, Christy Thai, Sweta Shah, Matthew Snyder
A man aged 65 years with metastatic renal cell carcinoma presented for evaluation after a recent fall. A thorough workup of the case was performed and secondary adrenal insufficiency induced by the administration of megestrol acetate was determined to be the cause. Adrenal insufficiency is a serious disorder that is a potential adverse event of megestrol acetate, a medication used to help patients with cancer cachexia increase their appetite and gain weight. This association is not well recognized in clinical practice, so this case highlights the importance of distinguishing possible endocrine complications induced by the long-term administration or sudden discontinuation of megestrol acetate...
April 2016: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/27191767/pharmacokinetics-of-a-nanocrystal-containing-megestrol-acetate-formulation-a-single-dose-randomized-open-label-2-part-2-period-crossover-study-in-healthy-korean-subjects
#10
Dong Woo Chae, Hankil Son, Jinju Guk, Changhun Park, Kyungsoo Park
UNLABELLED: <u> OBJECTIVE: </u> The conventional suspension of megestrol acetate contains micronized megestrol acetate, which was recently discovered to have a disadvantage of decreasing bioavailability when taken in a fasting state. Since megestrol acetate is taken to increase appetite, this property becomes a discouraging factor. To improve upon this, an advanced formulation was developed using a nanocrystal drug-delivery system. This study was conducted to compare the safety and pharmacokinetic characteristics between the conventional formulation of megestrol acetate and a generic version of the advanced formulation containing nanocrystals...
September 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27123883/systemic-therapy-for-recurrent-meningioma
#11
E Le Rhun, S Taillibert, M C Chamberlain
INTRODUCTION: Meningioma comprise 20-30% of all primary brain tumors. Notwithstanding surgery and radiotherapy, a subset of patients will manifest recurrent meningioma. Systemic therapy is recommended only when further surgery and radiotherapy are not possible. No prospective study with a high level of evidence is available to inform as to recommendations regarding systemic therapy. AREAS COVERED: We aim to summarize systemic therapies for recurrent meningioma. Expert commentary: Hydroxurea, temozolomide, irinotecan, the combination of cyclophosphamide/adriamycine/vincristine, interferon-alpha, somatostatin analogs, mifepristone, megestrol acetate, imatinib, erlotinib and gefitinib are considered as having limited efficacy...
August 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27098973/progesterone-therapy-for-the-treatment-of-non-cancer-cachexia-a-systematic-review
#12
REVIEW
Joanne K Taylor, Neil Pendleton
BACKGROUND: Cachexia describes a complex pathological syndrome of muscle wasting, anorexia and weight loss. Progesterone therapies have been shown to improve appetite and promote weight gain in patients with cachexia; however, research has focused heavily on patients with cancer, and its effectiveness in other diseases remains unclear. AIMS: This systematic review aimed to present the evidence available for progesterone therapy as a treatment for non-cancer cachexia...
September 2016: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/27066318/a-multifactorial-anti-cachectic-approach-for-cancer-cachexia-in-a-rat-model-undergoing-chemotherapy
#13
Míriam Toledo, Fabio Penna, Francesc Oliva, Melania Luque, Angelica Betancourt, Enrica Marmonti, Francisco J López-Soriano, Josep M Argilés, Sílvia Busquets
BACKGROUND: The effectiveness of drugs aimed at counteracting cancer cachexia is generally tested in pre-clinical rodent models, where only the tumour-induced alterations are taken into account, excluding the co-presence of anti-tumour molecules that could worsen the scenario and/or interfere with the treatment. METHODS: The aim of the present investigation has been to assess the efficacy of a multifactorial treatment, including formoterol and megestrol acetate, in cachectic tumour-bearing rats (Yoshida AH-130, a highly cachectic tumour) undergoing chemotherapy (sorafenib)...
March 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27060622/characterizing-the-dissolution-profiles-of-supersaturable-salts-cocrystals-and-solvates-to-enhance-in-vivo-oral-absorption
#14
Nozomi Hisada, Ryusuke Takano, Noriyuki Takata, Koji Shiraki, Takamitsu Ueto, Satoshi Tanida, Makoto Kataoka, Shinji Yamashita
The purposes of this study were to elucidate the type-specific characteristics of salt, cocrystal, and solvate formulations upon dissolution and precipitation, and to clarify their effect on enhancing oral absorption. Several types of solid formulations (dantrolene sodium salt [DAN-NA], pioglitazone hydrochloride salt [PIO-HCL], megestrol acetate saccharin cocrystal [MEG-SA], and an in-house compound ZR ethanolate [ZR-ETH]) that induce supersaturation of BCS class II drugs were compared to their crystalline free forms...
June 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27038209/the-binary-mixtures-of-megestrol-acetate-and-17%C3%AE-ethynylestradiol-adversely-affect-zebrafish-reproduction
#15
Jianghuan Hua, Jian Han, Xianfeng Wang, Yongyong Guo, Bingsheng Zhou
Synthetic progesterones and estrogens are broadly used bioactive pharmaceutical agents and have been detected in aquatic environments. In the present study, we investigated the combined reproductive effects of megestrol acetate (MTA) and 17α-ethinylestradiol (EE2) on zebrafish. Adult zebrafish were exposed to MTA (33, 100 or 333 ng/L), EE2 (10 ng/L) or a mixture of both (MTA + EE2: 33 + 10, 100 + 10 or 333 + 10 ng/L) for 21 days. Results demonstrated that egg production was significantly reduced by exposure to 10 ng/L EE2, but not MTA...
June 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27016228/tumor-mutational-analysis-of-gog248-a-phase-ii-study-of-temsirolimus-or-temsirolimus-and-alternating-megestrol-acetate-and-tamoxifen-for-advanced-endometrial-cancer-ec-an-nrg-oncology-gynecologic-oncology-group-study
#16
Andrea P Myers, Virginia L Filiaci, Yuping Zhang, Michael Pearl, Kian Behbakht, Vicky Makker, Parviz Hanjani, Susan Zweizig, James J Burke, Gordon Downey, Kimberly K Leslie, Paul Van Hummelen, Michael J Birrer, Gini F Fleming
OBJECTIVE: Rapamycin analogs have reproducible but modest efficacy in endometrial cancer (EC). Identification of molecular biomarkers that predict benefit could guide clinical development. METHODS: Fixed primary tissue and whole blood were collected prospectively from patients enrolled on GOG 248. DNA was isolated from macro-dissected tumors and blood; next-generation sequence analysis was performed on a panel of cancer related genes. Associations between clinical outcomes [response rate (RR) 20%; progression-free survival (PFS) median 4...
April 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/26971303/network-meta-analysis-comparing-overall-survival-for-fulvestrant-500-mg-versus-alternative-therapies-for-treatment-of-postmenopausal-estrogen-receptor-positive-advanced-breast-cancer-following-failure-on-prior-endocrine-therapy
#17
Claire Telford, Nick Jones, Christopher Livings, Sarah Batson
BACKGROUND: We conducted a review of randomized trials to compare the overall survival (OS) with fulvestrant 500 mg versus alternative treatment for estrogen receptor-positive advanced breast cancer following endocrine therapy failure. MATERIALS AND METHODS: Hazard ratios (HRs) were obtained by modeling OS data with the Weibull distribution. A fixed-effect Bayesian network meta-analysis was conducted. The evidence network included anastrozole 1 mg, letrozole 2.5 mg, fulvestrant 250 mg, exemestane 25 mg, megestrol acetate 40 mg, and everolimus 10 mg plus exemestane 25 mg as comparators...
June 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/26938779/use-of-an-ophthalmic-formulation-of-megestrol-acetate-for-the-treatment-of-eosinophilic-keratitis-in-cats
#18
Jean Stiles, Martin Coster
OBJECTIVE: To evaluate a compounded ophthalmic formulation of 0.5% megestrol acetate to treat eosinophilic keratitis in cats. STUDY DESIGN: Prospective study. ANIMALS STUDIED: Seventeen client owned cats with eosinophilic keratitis in one or both eyes. METHODS: Eosinophilic keratitis was confirmed by cytology. At each visit, fluorescein staining and photography were performed. Cats were initially treated q 8-12 h with 0...
July 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/26937477/prolonged-response-to-exemestane-following-multiple-surgical-resections-and-hormonal-therapies-in-a-patient-with-recurrent-endometrial-stromal-sarcoma
#19
Heather Wolfe, Kristen Bunch, Michael Stany
BACKGROUND: Endometrial stromal sarcomas (ESSs) are rare, indolent tumors with high recurrence rates. Management includes surgery and hormonal therapy given high estrogen and progesterone receptor (ER/PR) expression. CASE: A pre-menopausal patient with stage II ESSs (ER +/PR +) underwent primary surgery followed by adjuvant megestrol. Recurrence in the bladder/upper vagina (ER +/PR -) was diagnosed one year later and treated with anterior pelvic exenteration and adjuvant letrozole...
January 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/26929669/clinical-utility-of-dronabinol-in-the-treatment-of-weight-loss-associated-with-hiv-and-aids
#20
REVIEW
Melissa E Badowski, Sarah E Perez
Since the beginning of the HIV/AIDS epidemic, weight loss has been a common complaint for patients. The use of various definitions defining HIV wasting syndrome has made it difficult to determine its actual prevalence. Despite the use of highly active antiretroviral therapy, it is estimated that the prevalence of HIV wasting syndrome is between 14% and 38%. HIV wasting syndrome may stem from conditions affecting chewing, swallowing, or gastrointestinal motility, neurologic disease affecting food intake or the perception of hunger or ability to eat, psychiatric illness, food insecurity generated from psychosocial or economic concerns, or anorexia due to medications, malabsorption, infections, or tumors...
2016: HIV/AIDS: Research and Palliative Care
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