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Weight loss in the elderly

Yu Ohkura, Shusuke Haruta, Tsuyoshi Tanaka, Masaki Ueno, Harushi Udagawa
BACKGROUND: We aimed to investigate the efficacy of postoperative early intervention with an elemental diet to reduce weight loss and enhance recovery after gastrectomy. Nutritional status and gastrointestinal immune function tend to worsen, and postoperative weight loss is inevitable in these patients; therefore, improvement in their postoperative condition is important, especially in gastric cancer patients aged ≥80 years. METHODS: Clinical outcomes and postoperative nutritional status were compared between 21 and 22 consecutive elderly patients aged ≥80 years who underwent distal gastrectomy before and after the introduction of postoperative oral elemental diet (Elental®, 300 kcal/day), respectively, between October 2011 and June 2016...
October 19, 2016: World Journal of Surgical Oncology
Angela K Beckert, Megan Huisingh-Scheetz, Katherine Thompson, Amy D Celauro, Jordan Williams, Paul Pachwicewicz, Mark K Ferguson
BACKGROUND: The presence of frailty or prefrailty in older adults is a risk factor for postsurgical complications. The frailty phenotype can be improved through long-term resistance and aerobic training. It is unknown whether short-term preoperative interventions targeting frailty will help to mitigate surgical risk. The purpose of this study was to determine the proportion of frail and prefrail patients presenting to a thoracic surgical clinic who could benefit from a frailty reduction intervention...
October 4, 2016: Annals of Thoracic Surgery
Yao Wang, Xiaoyan Yi, Qifu Li, Jun Zhang, Zhihong Wang
BACKGROUND: This systematic review was performed to compare the effectiveness and safety of SG in the obese elderly patients with the young ones. METHODS: Cohort studies that compared outcomes among old and young patients who had undergone SG were included. Summary odds ratios were estimated using a random effect model. RESULTS: Eleven studies were included. Old patients had a worse outcome in percentage of excess weight loss than the young ones (SMD -0...
October 6, 2016: Obesity Surgery
Sami Hamdan Alzahrani, Ismail Abdelmoneim El Sayed, Sarah Mohammed Alshamrani
BACKGROUND: Malnutrition is highly prevalent among the elderly and is associated with poor clinical prognosis, decreased functional status, and increased morbidity and mortality. OBJECTIVE: To estimate the prevalence of geriatric malnutrition among outpatients of a geriatric clinic and to determine factors associated with malnutrition. DESIGN: Cross-sectional study. SETTING: Geriatric outpatient clinic of the King Abdul Aziz University Hospital, Jeddah...
September 2016: Annals of Saudi Medicine
Ying Hua, Yue-Ying Jiao, Yao Ma, Xiang-Lei Peng, Yuan-Hui Fu, Yan-Peng Zheng, Tao Hong, Jin-Sheng He
Human respiratory syncytial virus (RSV) can cause serious infection in the lower respiratory tract, especially in infants, young children, the elderly and the immunocompromised population worldwide. Previous study demonstrated the polypeptide (amino acids 148-198) of RSV attachment (G) glycoprotein, corresponding to the central conserved region and encompassing CX3C chemokine motif, could induce antibodies and protection from RSV challenge in mice [1,2]. In this study, we evaluated the immune efficacy of the recombinant DNA vaccine of pVAX1/3G148-198 encoding RSV G protein polypeptide...
September 26, 2016: Immunology Letters
Martin Nilsson, Daniel Sundh, Dan Mellström, Mattias Lorentzon
Physical activity is believed to have the greatest effect on the skeleton if exerted early in life, but whether or not possible benefits of physical activity on bone microstructure or geometry remain at old age has not been investigated in women. The aim of this study was to investigate if physical activity during skeletal growth and young adulthood or at old age was associated with cortical geometry and trabecular microarchitecture in weight-bearing and non-weight bearing bone, and areal bone mineral density (aBMD) in elderly women...
September 27, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
John E Morley
Frailty is a pre-disability syndrome where an older person can be identified as being at risk when exposed to stressors associated with high risk for disability or needing to be hospitalized. Two major frailty definitions exist. The physical phenotype of frailty and the multiple deficit model. A simple frailty screening tool-FRAIL-has been validated. Treatment of frailty involves resistance exercise, optimization of nutrition, and treatment of fatigue (sleep apnea, depression), treatable causes of weight loss and adjustment of polypharmacy...
September 26, 2016: Wiener Klinische Wochenschrift
Dolores Sánchez-Rodríguez, Ester Marco, Natalia Ronquillo-Moreno, Ramón Miralles, Olga Vázquez-Ibar, Ferran Escalada, Josep M Muniesa
BACKGROUNDS & AIMS: The European Society of Clinical Nutrition and Metabolism (ESPEN) consensus definition of malnutrition has been applied in hospitalized older diabetics and middle-aged patients, geriatric outpatients, and healthy elderly and young individuals. In a post-acute care setting, our aim was to assess malnutrition (ESPEN definition) and determine its relationship with sarcopenia in older in-patients deconditioned due to an acute process. METHODS: Eighty-eight in-patients aged ≥70 years with body mass index (BMI) <30 kg/m(2) were included (84...
September 9, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Julia Wojzischke, Rebecca Diekmann, Jürgen M Bauer
In later life a high body mass index (BMI) is associated with the lowest age-related mortality rate. The BMI range used by the World Health Organization (WHO) to classify overweight, a BMI of 25-30 kg/m(2), can be regarded as normal weight in old age; nevertheless, obesity is associated with an increased risk of disability and of a deterioration in physical functionality, particularly among older age groups. This relationship to obesity has also been established for frailty. For this reason, a reduction in weight may be appropriate under functional aspects if BMI values exceed 30 kg/m(2); however, such a decision cannot be made on the basis of an individual BMI alone...
October 2016: Zeitschrift Für Gerontologie und Geriatrie
Won-Jin Moon, Ju-Yeon Park, Won-Sung Yun, Ji Yeong Jeon, Yeon Sil Moon, Heejin Kim, Ki-Chang Kwak, Jong-Min Lee, Seol-Heui Han
OBJECTIVE: Neuromelanin loss of substantia nigra (SN) can be visualized as a T1 signal reduction on T1-weighted high-resolution imaging. We investigated whether volumetric analysis of T1 hyperintensity for SN could be used to differentiate between Parkinson's disease dementia (PDD), Alzheimer's disease (AD) and age-matched controls. MATERIALS AND METHODS: This retrospective study enrolled 10 patients with PDD, 18 patients with AD, and 13 age-matched healthy elderly controls...
September 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Adomas Bunevicius, Paulius Cikotas, Vesta Steibliene, Vytenis P Deltuva, Arimantas Tamsauskas
BACKGROUND: Intracranial aneurysms most commonly present following rupture causing subarachnoid hemorrhage. Mental disorders are common among patients with unruptured intracranial aneurysms and in aneurysmal subarachnoid hemorrhage survivors. However, to the best of our knowledge, there is no published report of unruptured intracranial aneurysm presenting as a mental disorder. CASE DESCRIPTION: A 69-year-old male without a past history of mental disorders and neurological symptoms presented with a 2-month history of anxiety, sadness, lack of pleasure in usual activities, fatigue, difficulties falling asleep and waking up early in the morning, reduced appetite, and weight loss...
2016: Surgical Neurology International
Qi Zeng, Jie Wang, Xing Lv, Jie Li, Li-Jie Yin, Yan-Qun Xiang, Xiang Guo
BACKGROUND: To date, no guideline is proposed for elderly nasopharyngeal carcinoma (NPC) due to lack of prospective clinical trials. The present study comparing the survivals and toxicities in elderly NPC patients received either induction chemotherapy followed by radiotherapy(IC + RT) or concurrent chemoradiotherapy (CCRT) was therefore undertaken to provide a more accurate basis for future clinical practice. METHODS: The eligible elderly NPC patients were retrospectively enrolled...
2016: BMC Cancer
Mohammad S Alam, Matthew Costales, Christopher Cavanaugh, Marion Pereira, Dennis Gaines, Kristina Williams
Foodborne Listeria monocytogenes (LM) is a cause of serious illness and death in the US. The case-fatality rate of invasive LM infection in the elderly population is >50%. The goal of this study is to establish a murine model of oral LM infection that can be used as a surrogate for human foodborne listeriosis in the geriatric population. Adult C57BL/6 (wild-type, WT) and adult or old IL17R-KO (knock-out) mice were gavaged with a murinized LM strain (Lmo-InlA(m)) and monitored for body-weight loss and survivability...
October 2016: Microbial Pathogenesis
Massimiliano Rizzi, Silvia Mazzuoli, Nunzia Regano, Rosa Inguaggiato, Margherita Bianco, Gioacchino Leandro, Elisabetta Bugianesi, Donatella Noè, Nicoletta Orzes, Paolo Pallini, Maria Letizia Petroni, Gianni Testino, Francesco William Guglielmi
AIM: To investigate the prevalence of undernutrition, risk of malnutrition and obesity in the Italian gastroenterological population. METHODS: The Italian Hospital Gastroenterology Association conducted an observational, cross-sectional multicenter study. Weight, weight loss, and body mass index were evaluated. Undernutrition was defined as unintentional weight loss > 10% in the last three-six months. Values of Malnutrition Universal Screening Tool (MUST) > 2, NRS-2002 > 3, and Mini Nutritional Assessment (MNA) from 17 to 25 identified risk of malnutrition in outpatients, inpatients and elderly patients, respectively...
July 15, 2016: World Journal of Gastrointestinal Oncology
Sayoni Saha, Daniel J Hatch, Kathleen M Hayden, David C Steffens, Guy G Potter
OBJECTIVE: Identify depression symptoms during active late-life depression (LLD) that predict conversion to dementia. METHODS: The authors followed a cohort of 290 participants from the Neurocognitive Outcomes of Depression in the Elderly study. All participants were actively depressed and cognitively normal at enrollment. Depression symptom factors were derived from prior factor analysis: anhedonia and sadness, suicidality and guilt, appetite and weight loss, sleep disturbance, and anxiety and tension...
October 2016: American Journal of Geriatric Psychiatry
Seok Min Hong, Il-Seok Park, Yong Bok Kim, Seok Jin Hong, Byungho Lee
BACKGROUND: Hearing loss can lead to a number of disabilities, subsequently reducing the quality of life. In general, hearing thresholds of adolescents are better than adults and the elderly. However, occasionally, adolescents acquire hearing loss for a number of reasons. In this study, our goal was to estimate the prevalence of hearing loss in the Korean population and to investigate the factors related to hearing thresholds in adolescents. METHODS: A cross-sectional study was conducted using data from the Korean National Health and Nutrition Examination Survey (KNHANES) between 2010 and 2012...
2016: PloS One
Kittichet Phiphatpatthamaamphan, RathaKorn Vilaichone
BACKGROUND: Colorectal cancer is one of the major health problems worldwide. However, limited studies have been reported from ASEAN countries. This study was conducted to evaluate clinical characteristics and survival of colorectal cancer cases aged <65 years and ≥65 years in the central region of Thailand. MATERIALS AND METHODS: Clinical information, histological features, endoscopic findings and treatment outcome were collected and reviewed from Thammasat University Hospital, Pathumthani, Thailand between November 2011 and October 2015...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Thanachai Punjachaipornpon, Varocha Mahachai, RathaKorn Vilaichone
BACKGROUND: Gastric cancer is the second leading cause of cancer death worldwide and occurs most frequently in the age group of 5070 years. Rarely reports have appeared regarding younger age groups. The purpose of this study was to compare clinical characteristics and outcome of treatment between young and elderly patients with gastric cancer in Thailand. MATERIALS AND METHODS: Clinical information, histological features, endoscopic findings and treatment outcome were reviewed and collected from Thammasat University Hospital, Pathumthani and Bangkok Medical Center, Bangkok, Thailand between September 2011March 2015...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
S Molino, M Dossena, D Buonocore, M Verri
Today's increased life expectancy highlights both age-related changes in body composition and a higher prevalence of obesity. Sarcopenic obesity (SO) is assuming a prominent role in cardio-metabolic risk because of the double metabolic burden derived from low muscle mass (sarcopenia) and excess adiposity (obesity). This review evaluates the related studies that have been published over the past 10 years in order to give an updated overview of this new syndrome. There is no consensus on the definition of SO due to the wide heterogeneity of diagnostic criteria and choice of body composition components needed to assess this phenotype...
2016: Journal of Nutrition, Health & Aging
Anne Camirand, David Goltzman, Ajay Gupta, Mohammadi Kaouass, Dibyendu Panda, Andrew Karaplis
Prolonged skeletal unloading through bedrest results in bone loss similar to that observed in elderly osteoporotic patients, but with an accelerated timeframe. This rapid effect on weight-bearing bones is also observed in astronauts who can lose up to 2% of their bone mass per month spent in Space. Despite the important implications for Spaceflight travelers and bedridden patients, the exact mechanisms involved in disuse osteoporosis have not been elucidated. Parathyroid hormone-related protein (PTHrP) regulates many physiological processes including skeletal development, and has been proposed as a mechanosensor...
2016: PloS One
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