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Weight loss in the elderly

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https://www.readbyqxmd.com/read/28428010/a-strategy-of-faster-movements-used-by-elderly-humans-to-lift-objects-of-increasing-weight-in-ecological-context
#1
Thomas Hoellinger, Joseph McIntyre, Lena Jami, Sylvain Hanneton, Guy Cheron, Agnes Roby-Brami
It is not known whether, during the course of ageing, changes occur in the motor strategies used by the CNS for lifting objects of different weights. Here, we analysed the kinematics of object-lifting in two different healthy groups (young and elderly people) plus one well known deafferented patient (GL). The task was to reach and lift onto a shelf an opaque cylindrical object with changing weight. The movements of the hand and object were recorded with electromagnetic sensors. In an ecological context (i.e...
April 17, 2017: Neuroscience
https://www.readbyqxmd.com/read/28420105/one-year-results-of-a-synthetic-intervention-model-for-the-primary-prevention-of-t2d-among-elderly-individuals-with-prediabetes-in-rural-china
#2
Zhao Hu, Lulu Qin, Huilan Xu
Objective: The objective of this study was to evaluate the effectiveness of a synthetic intervention model aimed at preventing type 2 diabetes and controlling plasma glucose, body weight and waist circumference in elderly individuals with prediabetes in rural China. Methods: We randomly assigned 434 (180 men and 254 women; mean age, 69 years; mean body mass index, 23.6 kg/m²) with prediabetes to either the intervention group or the control group. Each participant in the intervention group received synthetic intervention for 1 year...
April 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28418359/-a-rare-concurrence-of-polymyalgia-rheumatica-and-aa-amyloidosis
#3
S G Radenska-Lopovok, O N Kotenko, N F Frolova, A I Zagrebneva, E S Stolyarevich, E V Volodina, V I Chervinko, E V Kryukov, M L Zubkin
Polymyalgia rheumatica (PMR) is a rare chronic inflammatory disease. It predominantly affects the elderly. The disease has a slow onset, pain and stiffness in the muscles of the shoulder and pelvic girdle, fever, weight loss, and a high acute-phase inflammatory response. The disease is concurrent with giant cell arteritis in a quarter of cases, which allows some authors to consider them as two different manifestations of the same pathological process. The kidneys are rarely involved. This disease is rarely complicated by AA amyloidosis...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28405820/higher-dietary-acid-load-is-associated-with-a-higher-prevalence-of-frailty-particularly-slowness-weakness-and-low-physical-activity-in-elderly-japanese-women
#4
Yuki Kataya, Kentaro Murakami, Satomi Kobayashi, Hitomi Suga, Satoshi Sasaki
OBJECTIVE: Epidemiologic evidence on the potential effects of dietary acid load on frailty is lacking. This cross-sectional study examined the association between dietary acid load and frailty. METHODS: This study was based on self-reported data obtained from 2176 Japanese women aged 65-94 years. Dietary acid load was characterized as potential renal acid load (PRAL) and net endogenous acid production (NEAP), based on information on nutrient intake, obtained from a validated brief diet history questionnaire...
April 12, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28402960/feasibility-of-laparoscopic-gastrectomy-for-elderly-gastric-cancer-patients-meta-analysis-of-non-randomized-controlled-studies
#5
REVIEW
Liang Zong, Aiwen Wu, Wenyue Wang, Jingyu Deng, Susumu Aikou, Hiroharu Yamashita, Masahiro Maeda, Masanobu Abe, Duonan Yu, Zhiwei Jiang, Yasuyuki Seto, Jiafu Ji
The aim of this meta-analysis was to determine the feasibility of laparoscopic gastrectomy (LG) for elderly gastric cancer patients by comparing laparoscopic and conventional open gastrectomies (OG). Comprehensive search of the PubMed, EMBASE, and Cochrane Library databases revealed nine non-randomized controlled studies that compared LG and OG in elderly gastric cancer patients We then analyzed dichotomous or continuous parameters using odds ratios (ORs) or weighted mean differences (WMDs). Overall survival was estimated using hazard ratios (HRs) with a fixed effects or random effects model...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28396303/effect-of-a-nine-month-web-and-app-based-workplace-intervention-to-promote-healthy-lifestyle-and-weight-loss-for-employees-in-the-social-welfare-and-health-care-sector-a-randomized-controlled-trial
#6
Nina Charlotte Balk-Møller, Sanne Kellebjerg Poulsen, Thomas Meinert Larsen
BACKGROUND: General health promoting campaigns are often not targeted at the people who need them the most. Web- and app-based tools are a new way to reach, motivate, and help people with poor health status. OBJECTIVE: The aim of our study was to test a Web- and mobile app-based tool ("SoSu-life") on employees in the social welfare and health care sector in Denmark. METHODS: A randomized controlled trial was carried out as a workplace intervention...
April 10, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28388378/protein-turnover-and-metabolism-in-the-elderly-intensive-care-unit-patient
#7
Stuart M Phillips, Roland N Dickerson, Frederick A Moore, Douglas Paddon-Jones, Peter J M Weijs
Many intensive care unit (ICU) patients do not achieve target protein intakes particularly in the early days following admittance. This period of iatrogenic protein undernutrition contributes to a rapid loss of lean, in particular muscle, mass in the ICU. The loss of muscle in older (aged >60 years) patients in the ICU may be particularly rapid due to a perfect storm of increased catabolic factors, including systemic inflammation, disuse, protein malnutrition, and reduced anabolic stimuli. This loss of muscle mass has marked consequences...
April 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28387197/primary-hemiarthroplasty-for-treatment-of-unstable-pertrochanteric-femoral-fractures-ao-ota-type-31-a2-3-in-elderly-osteoporotic-patients
#8
Skender Ukaj, Bahri Gjyshinca, Vlora Podvorica, Fatime Ukaj, Granit Molliqaj, Arben Boshnjaku, Axel Gamulin
INTRODUCTION: The aim of this study was to prospectively analyze the role of primary hemiarthroplasty in unstable osteoporotic pertrochanteric fractures (AO/OTA Type 31 A2.3), with emphasis given to postoperative Functional Independent Measure (FIM) and Harris Hip Score (HHS). METHODS: Fifty-six consecutive patients (average age 78.25 ± 5.45), out of which 24 males (79.29 ± 4.99) and 32 females (77.47 ± 5.72), with unstable pertrochanteric femoral fractures, operated with primary hemiarthroplasty procedure from 2012 to 2014 were included in this prospective study with a follow-up of two years...
2017: SICOT-J
https://www.readbyqxmd.com/read/28385929/cemented-versus-cementless-hemiarthroplasty-for-a-displaced-fracture-of-the-femoral-neck-a-systematic-review-and-meta-analysis-of-current-generation-hip-stems
#9
REVIEW
H D Veldman, I C Heyligers, B Grimm, T A E J Boymans
AIMS: Our aim was to prepare a systematic review and meta-analysis to compare the outcomes of cemented and cementless hemiarthroplasty of the hip, in elderly patients with a fracture of the femoral neck, to investigate the mortality, complications, length of stay in hospital, blood loss, operating time and functional results. MATERIALS AND METHODS: A systematic review and meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines on randomised controlled trials (RCTs), studying current generation designs of stem only...
April 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28384263/universal-vaccine-against-respiratory-syncytial-virus-a-and-b-subtypes
#10
Jeong-Yoon Lee, Jun Chang
Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection in infants, young children, and the elderly. Two subtypes of RSV, A and B, circulate alternately at 1-2-year intervals during epidemics. The attachment glycoprotein (G protein) of RSV is one of the major targets for immune responses. In this study, we generated a recombinant fusion protein, GcfAB, which consists of the central regions (a.a. residues 131-230) of the G proteins of both RSV A (A2 strain) and B (B1 strain) subtypes, and investigated immunogenicity, protective efficacy, and immunopathology...
2017: PloS One
https://www.readbyqxmd.com/read/28383453/predictors-of-anastomotic-leak-in-elderly-patients-after-colectomy-nomogram-based-assessment-from-the-american-college-of-surgeons-national-surgical-quality-program-procedure-targeted-cohort
#11
Ahmet Rencuzogullari, Cigdem Benlice, Michael Valente, Maher A Abbas, Feza H Remzi, Emre Gorgun
BACKGROUND: Elderly patients undergoing colorectal surgery have increasingly become under scrutiny by accounting for the largest fraction of geriatric postoperative deaths and a significant proportion of all postoperative complications, including anastomotic leak. OBJECTIVE: This study aimed to determine predictors of anastomotic leak in elderly patients undergoing colectomy by creating a novel nomogram for simplistic prediction of anastomotic leak risk in a given patient...
May 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28371292/outcomes-of-laparoscopic-sleeve-gastrectomy-in-elderly-obese-japanese-patients
#12
Aiko Hayashi, Yukari Maeda, Minoru Takemoto, Hirotake Tokuyama, Hisashi Koide, Aya Kitahara, Hideki Hayashi, Takumi Kitamoto, Masaya Yamaga, Kazuki Kobayashi, Koutaro Yokote
AIM: Laparoscopic sleeve gastrectomy (LSG) has proven to be the most effective strategy for the treatment of morbid obesity, however its efficacy and safety in an aging population has not yet been confirmed. In this study, we evaluated the effectiveness and safety of LSG in elderly obese Japanese patients. METHODS: Three obese individuals aged >60 years and 11 obese individuals aged <60 years who underwent LSG were enrolled. Pre- and postoperative changes after at least 12 months were examined, including bodyweight, body mass index, total weight loss, excess weight loss, bone mineral density and bone-related markers...
March 30, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28359689/frailty-measure-is-more-predictive-of-outcomes-after-curative-therapy-for-endometrial-cancer-than-traditional-risk-factors-in-women-60-and-older
#13
Jane A Driver, Akila N Viswanathan
OBJECTIVES: To determine if readily obtainable markers of frailty predict disease-free survival (DFS) in elderly women with endometrial cancer treated with curative intent. METHODS: 88 consecutive women≥age 60 treated with surgery, chemotherapy and radiation for stage I-IV endometrial cancer were included. We considered the following health deficits as markers of "frailty": albumin <3.5mg/dL, hemoglobin <10mg/dL, BMI<20kg/m,(2) unintentional weight loss, ECOG performance status ≥2, history of osteopenia or osteoporosis and Charlson comorbidity score...
March 27, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28359364/age-dependent-risk-factors-for-malnutrition-in-traumatology-and%C3%A2-orthopedic-patients
#14
Christine Lambert, Andreas Nüssler, Hans Konrad Biesalski, Thomas Freude, Christian Bahrs, Gunnar Ochs, Ingo Flesch, Ulrich Stöckle, Christoph Ihle
OBJECTIVE: The aim of this study was to investigate the prevalence of risk of malnutrition (RoM) in an orthopedic and traumatology patient cohort with a broad range of ages. In addition to the classical indicators for risk assessment (low body mass index, weight loss, and comorbidity), this study aimed to analyze the effects of lifestyle factors (eating pattern, smoking, physical activity) on RoM. METHODS: The prospective cohort study included 1053 patients in a level 1 trauma center in Germany...
May 2017: Nutrition
https://www.readbyqxmd.com/read/28326295/role-of-the-cytokine-like-hormone-leptin-in-muscle-bone-crosstalk-with-aging
#15
REVIEW
Mark W Hamrick
The cytokine-like hormone leptin is a classic adipokine that is secreted by adipocytes, increases with weight gain, and decreases with weight loss. Additional studies have, however, shown that leptin is also produced by skeletal muscle, and leptin receptors are abundant in both skeletal muscle and bone-derived mesenchymal (stromal) stem cells. These findings suggest that leptin may play an important role in muscle-bone crosstalk. Leptin treatment in vitro increases the expression of myogenic genes in primary myoblasts, and leptin treatment in vivo increases the expression of microRNAs involved in myogenesis...
February 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28326112/associations-of-upper-arm-and-thigh-circumferences-with-dementia-and-depression-in-korean-elders
#16
Yong-Seong Lee, Sang-Dae Kim, Hee-Ju Kang, Sung-Wan Kim, Il-Seon Shin, Jin-Sang Yoon, Jae-Min Kim
OBJECTIVE: Previous studies have reported an association between weight loss and cognitive impairment. Changes in anthropometric measurements, such as arm and thigh circumferences, are associated with body mass changes and physical activity. Our aim was to investigate the association of upper arm and thigh circumferences with dementia and depression in the community-dwelling elderly population. METHODS: In total, 2,498 community residents aged 65 years or over were clinically assessed for dementia using the Korean version of the Community Screening Interview for Dementia...
March 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28323025/ability-to-predict-resting-energy-expenditure-with-six-equations-compared-to-indirect-calorimetry-in-octogenarian-men
#17
Mikael Karlsson, Erika Olsson, Wulf Becker, Brita Karlström, Tommy Cederholm, Per Sjögren
The accuracy of predictive equations for calculating resting energy expenditure (REE) in elderly people has been questioned. Aging is associated with progressive declines in REE, which partly is explained by loss of fat free mass (FFM). Against this background we aimed to identify the most accurate predictive equation for REE in octogenarian men, taking body composition into account and using indirect calorimetry as reference value. REE was measured in 22 men (mean age 82.6±0.3years) and compared with six predictive equations: two based on FFM and four based on body weight, height and/or age...
June 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28300617/sex-and-gender-related-prevalence-cardiovascular-risk-and-therapeutic-approach-in-metabolic-syndrome-a-review-of-the-literature
#18
REVIEW
Giacomo Pucci, Riccardo Alcidi, Lisanne Tap, Francesca Battista, Francesco Mattace-Raso, Giuseppe Schillaci
Metabolic syndrome (MS), a cluster of metabolic abnormalities linked to insulin-resistance and abdominal obesity, is associated with an increased risk of Type II diabetes mellitus (DM) and cardiovascular (CV) disease. Its prevalence is high, affecting 20%-30% of the general population, and increases with age in a sex-specific manner: in fact, while below 50 years it is slightly higher in men, it reverses after 50 years. The pronounced age-related increase in the prevalence of MS in women occurs as the result of several factors, which may be classified into sex- and gender-related factors...
March 12, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28286988/exercise-and-nutritional-approaches-to-prevent-frail-bones-falls-and-fractures-an-update
#19
REVIEW
R M Daly
Osteoporosis (low bone strength) and sarcopenia (low muscle mass, strength and/or impaired function) often co-exist (hence the term 'sarco-osteoporosis') and have similar health consequences with regard to disability, falls, frailty and fractures. Exercise and adequate nutrition, particularly with regard to vitamin D, calcium and protein, are key lifestyle approaches that can simultaneously optimize bone, muscle and functional outcomes in older people, if they are individually tailored and appropriately prescribed in terms of the type and dose...
April 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28250246/age-related-normative-values-for-handgrip-strength-and-grip-strength-s-usefulness-as-a-predictor-of-mortality-and-both-cognitive-and-physical-decline-in-older-adults-in-northwest-russia
#20
A Turusheva, E Frolova, J-M Degryse
OBJECTIVES: This paper sought to provide normative values for grip strength among older adults across different age groups in northwest Russia and to investigate their predictive value for adverse events. METHODS: A population-based prospective cohort study of 611 community-dwelling individuals 65+. Grip strength was measured using the standard protocol applied in the Groningen Elderly Tests. The cut-off thresholds for grip strength were defined separately for men and women of different ages using a weighted polynomial regression...
March 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
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