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https://www.readbyqxmd.com/read/29049463/prevalence-of-age-related-macular-degeneration-in-australia-the-australian-national-eye-health-survey
#1
Stuart Keel, Jing Xie, Joshua Foreman, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
Importance: Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among the elderly population globally. Currently, knowledge of the epidemiology of AMD in Australia remains scarce because of a paucity of recent population-based data. Objective: To examine the prevalence of AMD in Australia. Design, Setting, and Participants: In this population-based, cross-sectional survey performed from March 11, 2015, to April 18, 2016, a sample of 3098 nonindigenous Australians 50 years and older and 1738 indigenous Australians 40 years and older from 30 geographic areas across Australia were examined...
October 12, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29043211/native-valve-endocarditis-caused-by-achromobacter-xylosoxidans-a-case-report-and-review-of-literature
#2
Caio Godoy Rodrigues, Jairo Rays, Marcia Yoshie Kanegae
Achromobacter xylosoxidans is a Gram-negative aerobic bacterium first described by Yabuuchi and Ohyama in 1971. A. xylosoxidans is frequently found in aquatic environments. Abdominal, urinary tract, ocular, pneumonia, meningitis, and osteomyelitis are the most common infections. Infective endocarditis is rare. As far as we know, until now, only 19 cases have been described, including this current report. We report the case of community-acquired native valve endocarditis caused by A. xylosoxidans in an elderly patient without a concomitant diagnosis of a malignancy or any known immunodeficiency...
July 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/29040554/frailty-syndrome-an-emerging-clinical-problem-in-the-everyday-management-of-clinical-arrhythmias-the-results-of-the-european-heart-rhythm-association-survey
#3
Stefano Fumagalli, Tatjana S Potpara, Torben Bjerregaard Larsen, Kristina H Haugaa, Dan Dobreanu, Alessandro Proclemer, Nikolaos Dagres
The age of patients presenting with complex arrhythmias is increasing. Frailty is a multifaceted syndrome characterized by an increased vulnerability to stressors and a decreased ability to maintain homeostasis. The prevalence of frailty is associated with age. The aims of this European Heart Rhythm Association (EHRA) EP Wire survey were to evaluate the proportion of patients with frailty and its influence on the clinical management of arrhythmias. A total of 41 centres-members of the EHRA Electrophysiology Research Network-in 14 European countries completed the web-based questionnaire in June 2017...
October 10, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29026760/etiological-and-clinicopathological-study-of-secondary-small-vessel-vasculitis-in-elderly-a-case-series-of-12-patients
#4
Ajay Kumar Mishra, Ramya Iyadurai, Anu Anna George, Ebenezer Rajdurai, V Surekha
BACKGROUND: Inflammation involving the postcapillary venular wall is defined as small vessel vasculitis. Small vessel vasculitis has various clinical manifestations. Etiologically, it can be primary or secondary. Literature regarding secondary vasculitis in elderly is scanty. AIM AND OBJECTIVES: In this case series, we aimed to assess the clinical features and etiologies of biopsy-proven secondary small vessel vasculitis in the elderly. METHODOLOGY: Twelve elderly patients with biopsy-proven small vessel vasculitis were included in this study...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29020715/diagnosis-and-management-of-polymyalgia-rheumatica
#5
Olwyn Jones, Fraser Birrell
Polymyalgia rheumatica (PMR) is a common inflammatory condition of unknown aetiology with a prevalence of 1 in 133 in the over 50s, and a female to male ratio of 2:1. Symptoms develop over a matter of weeks; typically bilateral shoulder or pelvic girdle pain and stiffness, that is worse in the mornings. Associated symptoms include low-grade fever, malaise, fatigue, low mood, poor appetite, and weight loss. There is no specific diagnostic test for PMR but the usual pattern is a commensurate rise in CRP and ESR...
December 2016: Practitioner
https://www.readbyqxmd.com/read/28985342/the-effect-of-head-and-neck-radiotherapy-on-blood-pressure-and-orthostatic-hypotension-in-patients-with-head-and-neck-tumors
#6
Avshalom Leibowitz, Ehud Grossman, Anat Berkovitch, Meital Levartovski, Sarit Appel, Yehonatan Sharabi, Iris Gluck
Background: Radiotherapy (RT) plays a key role in the management of head and neck cancer (HNC), especially in locally advanced disease. Patients undergoing head and neck RT, especially elderly ones, are suffering from low and labile blood pressure (BP) during the treatment. They complain of weakness and fatigue and are prone to recurrent falls. The aim of this study was to characterized BP changes during RT period. Methods: Patients with HNC, recieving radiation to the neck, were recruited from Sheba medical center RT unit...
August 29, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28982190/weight-loss-from-20-years-of-age-is-associated-with-cognitive-impairment-in-middle-aged-and-elderly-individuals
#7
Kaori Kitamura, Yumi Watanabe, Kazutoshi Nakamura, Akemi Takahashi, Ribeka Takachi, Rieko Oshiki, Ryosaku Kobayashi, Toshiko Saito, Shoichiro Tsugane, Ayako Sasaki
BACKGROUND: Few empirical studies have been conducted to identify modifiable factors that may affect cognitive impairment in Japanese individuals. The present study aimed to clarify whether body mass and lifestyle are associated with cognitive impairment in Japanese middle-aged and elderly individuals. METHODS: Subjects were 1814 community-dwelling individuals aged 44-79 years, all of whom were participants of the Murakami Cohort Study baseline survey conducted in 2011-2013...
2017: PloS One
https://www.readbyqxmd.com/read/28972237/the-effects-of-weight-and-waist-change-on-the-risk-of-long-term-mortality-in-older-adults-the-bambu%C3%A3-brazil-cohort-study-of-aging
#8
A M Beleigoli, M D F H Diniz, E Boersma, J L Silva, M F Lima-Costa, A L Ribeiro
OBJECTIVE: We aimed to investigate the risk of long-term mortality associated with weight and waist circumference (WC) change among older adults, particularly the overweight and obese ones. DESIGN: Cohort Study. SETTING: The Bambuí (Brazil) Cohort Study of Aging. PARTICIPANTS: Community-dwelling elderly (n=1138). MEASUREMENTS: Weight and WC were reassessed three years after baseline. Mortality risk associated with a 5% weight/WC loss and gain was compared to that of weight/WC stability by Cox models adjusted for clinical, behavioral and social known risk factors for death (age, gender, BMI, smoking, diabetes, total cholesterol, hypertension, Chagas disease, major electrocardiographic changes, physical activity, B-type natriuretic peptide, C-reactive protein, creatinine, education and household income)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28966459/epstein-barr-virus-positive-diffuse-large-b-cell-lymphoma
#9
Stacey L Murthy, Michael A Hitchcock, Tiana R Endicott-Yazdani, John T Watson, John R Krause
While the World Health Organization included Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) as a provisional entity of a lymphoma occurring in older individuals without any known immunodeficiency in 2008, it has since been recognized that this entity may occur in younger individuals. As a result, the 2016 revision has substituted the modifier "elderly" with "not otherwise specified" (NOS). The NOS highlights that there are more specific entities with neoplastic EBV-positive large B cells such as lymphomatoid granulomatosis...
October 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28956710/fermented-rice-germ-extract-alleviates-morphological-and-functional-damage-to-murine-gastrocnemius-muscle-by-inactivation-of-amp-activated-protein-kinase
#10
Miyu Tanaka, Yuta Yoshino, Shogo Takeda, Kazuya Toda, Hiroshi Shimoda, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara
Sarcopenia, loss of muscle mass and function, is mainly observed in elderly people. In this study, we investigated whether fermented rice germ extract (FRGE) has some effects on the mouse gastrocnemius muscle by using behavioral and morphological analyses, Western blotting, and a murine model of immobilization-induced muscle atrophy. Daily oral FRGE administration increased muscle weight and strength. In addition, myofiber size in gastrocnemius muscle of FRGE-treated mice was increased as revealed by morphological quantification...
October 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28955440/effects-of-low-dose-lipopolysaccharide-and-age-on-spatial-learning-in-different-morris-water-maze-protocols
#11
Barbara J Kupferschmid, Barbara Therrien, Pamela J Rowsey
OBJECTIVES: Animals administered lipopolysaccharide exhibit dose-related sickness behaviors (decreased food intake, weight loss, and cognitive changes). While research has demonstrated that spatial learning is impaired following a lipopolysaccharide immune challenge, the results differ depending on the methodology used to evaluate spatial learning. Additionally, few studies have evaluated the effects of low-dose lipopolysaccharide on spatial learning. Therefore, we assessed spatial learning, food intake, and weight changes in adult and aged rats after a low-dose lipopolysaccharide immune challenge in the Morris water maze using two water temperatures...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28947687/-gustation-and-dysgeusia
#12
Takashi Sasano
The enjoyment of tastes should be one of the greatest pleasures in life. Without the sense of taste, one cannot enjoy one's food. The result would then be poor appetite, eating less and weight loss. As the elderly population in Japan increases, the number of patients suffering from taste disorder has also increased. While changes in the ability to distinguish tastes are partly associated with advancing age, they occur moreover in response to secondary influences, such as the side effects of drugs, or the effects of some diseases including periodontal disease/oral infections, nervous disorders, nutritional impairment, and endocrine disorders...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28943182/the-relationship-between-the-dietary-inflammatory-index-and-incident-frailty-a-longitudinal-cohort-study
#13
Nitin Shivappa, Brendon Stubbs, James R Hébert, Matteo Cesari, Patricia Schofield, Pinar Soysal, Stefania Maggi, Nicola Veronese
OBJECTIVE: Inflammation is key risk factor for several conditions in the elderly. However, the relationship between inflammation and frailty is still unclear. We investigated whether higher dietary inflammatory index (DII) scores were associated with higher incidence of frailty in a cohort of North Americans. DESIGN: Longitudinal, with a follow-up of 8 years. SETTING: Osteoarthritis Initiative. PARTICIPANTS: A total of 4421 participants with, or at high risk of, knee osteoarthritis...
September 21, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28942708/laparoscopic-roux-en-y-gastric-bypass-in-elderly-patients-60%C3%A2-years-or-older-a-meta-analysis-of-comparative-studies
#14
S Giordano, M Victorzon
BACKGROUND AND AIMS: Elderly patient might experience an increased risk of complications after laparoscopic Roux-en-Y gastric bypass. We aimed to perform a meta-analysis of comparative studies on this issue in patients aged 60 years or older. MATERIAL AND METHODS: A systematic literature search was performed. Medline, Cochrane Library, Embase, Scopus, and Google Scholar were searched until July 2016 for studies on outcomes of laparoscopic Roux-en-Y gastric bypass in elderly versus younger patients...
September 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28939527/assessment-of-fructose-overload-in-the-metabolic-profile-and-oxidative-nitrosative-stress-in-the-kidney-of-senescent-female-rats
#15
Deborah Chianelli Costalonga Seraphim, Giovana Rita Punaro, Thamires de Oliveira Fernandes, Milton Ginoza, Guiomar Silva Lopes, Elisa Mieko Suemitsu Higa
The aging process is a complex phenomenon that leads the body to several changes, affecting its integrity and resulting in chronic pathologies, which compromises health and quality of life of elderly people. Animals supplemented with fructose have been used as an experimental model for induction of insulin resistance. The objective of this study was to evaluate the metabolic effects and the levels of oxidative/nitrosative stress in the kidney of senescent rats with a high fructose intake. The animals were allocated into 4 groups: young control (Y), aged control (A), young fructose (YF) and aged fructose (AF)...
September 20, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28921839/hepatoblastoma-in-children-aged-less-than-six-months-at-diagnosis-a-report-from-the-siopel-group
#16
Patrizia Dall'Igna, Laurence Brugieres, Anne Sanlaville Christin, Rudolf Maibach, Michela Casanova, Rita Alaggio, Jean de Ville de Goyet, Jozsef Zsiros, Bruce Morland, Piotr Czauderna, Margaret Childs, Daniel C Aronson, Sophie Branchereau, Penelope Brock, Giorgio Perilongo
BACKGROUND: The purpose of this study was to evaluate clinical characteristics, treatment, and survival of children, who were diagnosed with hepatoblastoma (HB) in their first 6 months of age, enrolled in the SIOPEL 2 and 3 protocols. METHODS: Seventy-nine patients, treated between 1994 and 2006, were analyzed after stratification into three age groups: <1 month, between 1 and 3 months, and between 3 and 6 months. All received preoperative chemotherapy. RESULTS: Clinical characteristics were similar in both trials: 4 patients had pulmonary metastases at diagnosis, 4 had α-fetoprotein <100 ng/ml, 68 were operated by partial hepatectomy, and 7 received liver transplant...
September 18, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28917223/validity-of-the-malnutrition-universal-screening-tool-must-in-australian-hospitalized-acutely-unwell-elderly-patients
#17
Yogesh Sharma, Campbell Thompson, Billingsley Kaambwa, Rashmi Shahi, Michelle Miller
BACKGROUND AND OBJECTIVES: This study validated the Malnutrition Universal Screening Tool (MUST) for nutritional screening in acutely unwell elderly patients against a reference assessment tool - Patient-Generated Subjective Global Assessment (PG-SGA). METHODS AND STUDY DESIGN: One hundred and thirty two acutely admitted general medical patients contributed data for this study. In addition to performance of MUST and PG-SGA the following nutritional parameters were measured: weight loss >5% in previous 3-6 months, handgrip strength, triceps skinfold thickness, Mid-arm circumference, Mid-arm muscle circumference (MAMC)...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28894077/-experience-of-frailty-in-korean-elderly-a-phenomenological-study-utilizing-the-colaizzi-method
#18
Jin Kyoung Park
PURPOSE: This study attempts to explore the subjective experience of frailty among elderly individuals in Korea. METHODS: From June to August in 2014, 11 elderly persons who had experienced frailty in a community were interviewed. For data analysis, the method suggested by Colaizzi was applied as a phenomenological method. RESULTS: According to the analysis, the study participants' frailty process was structured in seven categories: (a) 'natural phenomenon with ageing,' (b) 'life force comes to an end,' (c) 'the light in my heart turns off,' (d) 'unavoidable situation,' (e) 'continuous and connected vicious cycle,' (f) 'the limit of recovery energy already passes,' and (g) 'life is supported by someones help...
August 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28891299/spatial-learning-responses-to-lipopolysaccharide-in-adult-and-aged-rats
#19
Barbara J Kupferschmid, Barbara A Therrien
Sickness behaviors, adaptive responses to infections, include lethargy, depression, reduced eating and grooming, and concentration problems resulting from interactions between the immune and neuroendocrine systems. Detecting these responses is especially critical in the elderly, as the infections that cause them can lead to cognitive impairment. While deficits in spatial learning, a hippocampal-dependent form of learning, are part of the sickness response, directional heading errors (DHEs; an indicator of spatial-learning deficits) and their time trajectories need further examination...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28889231/favorable-effects-of-early-tolvaptan-administration-in-very-elderly-patients-after-repeat-hospitalizations-for-acute-decompensated-heart-failure
#20
Masaki Kinoshita, Hideki Okayama, Tetsuya Kosaki, Saki Hosokawa, Go Kawamura, Tatsuya Shigematsu, Tatsunori Takahashi, Yoshitaka Kawada, Go Hiasa, Tadakatsu Yamada, Hiroshi Matsuoka, Yukio Kazatani
Tolvaptan (TLV) is an oral selective vasopressin 2 receptor antagonist that acts on the distal nephrons, causing a loss of electrolyte-free water. To date, its early administration in very elderly patients after repeat hospitalizations for acute decompensated heart failure (ADHF) despite receiving optimal medical therapy has not been evaluated. Fifty-six ADHF patients who were >80 years old and had been repeatedly hospitalized were retrospectively enrolled in this study. Twenty-five patients (14 men; mean age 86...
September 9, 2017: Heart and Vessels
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