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https://www.readbyqxmd.com/read/29143491/fine-needle-aspiration-evaluation-of-pancreatic-lymphoma-a-retrospective-study-of-25-cases-in-a-single-institution
#1
Jiehao Zhou, Howard Wu, Jingmei Lin, Xiaoyan Wang, Shanxiang Zhang, Harvey Cramer, Shaoxiong Chen
BACKGROUND: Accurate diagnosis of pancreatic lymphoma is crucial for clinical management. We evaluate the role of fine-needle aspiration (FNA) in the diagnosis of pancreatic lymphoma with the aid of flow cytometry and/or immunohistochemistry on the cell block. METHODS: Cases of pancreatic lymphoma were collected by searching our pathology laboratory information system over a period of 16 years. The clinical findings, cytologic features, and immunophenotypic results were reviewed...
November 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29135992/internal-quality-assurance-in-diagnostic-microbiology-a-simple-approach-for-insightful-data
#2
Valentin Scherz, Christian Durussel, Gilbert Greub
Given the importance of microbiology results on patient care, high quality standards are expected. Internal quality assurance (IQA) could mitigate the limitations of internal quality control, competency assessment and external quality assurance, adding a longitudinal insight, including pre- and post-analytical steps. Here, we implemented an IQA program in our clinical microbiology facilities with blind resubmission of routine samples during 22 months. One-hundred-and-twenty-one out of 123 (98.4%) serological analyses and 112 out of 122 (91...
2017: PloS One
https://www.readbyqxmd.com/read/29130601/scaling-up-hiv-viral-load-lessons-from-the-large-scale-implementation-of-hiv-early-infant-diagnosis-and-cd4-testing
#3
Trevor Peter, Clement Zeh, Zachary Katz, Ali Elbireer, Bereket Alemayehu, Lara Vojnov, Alex Costa, Naoko Doi, Ilesh Jani
INTRODUCTION: The scale-up of effective HIV viral load (VL) testing is an urgent public health priority. Implementation of testing is supported by the availability of accurate, nucleic acid based laboratory and point-of-care (POC) VL technologies and strong WHO guidance recommending routine testing to identify treatment failure. However, test implementation faces challenges related to the developing health systems in many low-resource countries. The purpose of this commentary is to review the challenges and solutions from the large-scale implementation of other diagnostic tests, namely nucleic-acid based early infant HIV diagnosis (EID) and CD4 testing, and identify key lessons to inform the scale-up of VL...
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29122793/developing-a-classification-system-for-haemoglobin-management-in-patients-with-end-stage-renal-disease-on-haemodialysis-a-secondary-data-analysis
#4
Tibor Kesztyüs, Ulrich Simonsmeier, Dorothea Kesztyüs
BACKGROUND: Ongoing discussion on anaemia management and target haemoglobin (Hb) levels in patients on haemodialysis with erythropoietin treatment require a systematic approach in evaluating current practice. Aim of the present study was to develop a new classification system to easily monitor Hb trajectories and categorise patients on haemodialysis. METHODS: Routine data from five dialysis centres in the USA collected between 2010 and 2016. Data were anonymised and only those from patients with fortnightly Hb values were included in the analysis...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29118166/laboratory-focus-on-improving-the-culture-of-biosafety-statewide-risk-assessment-of-clinical-laboratories-that-process-specimens-for-microbiologic-analysis
#5
Erik Munson, Erin J Bowles, Richard Dern, Eric Beck, Raymond P Podzorski, Allen C Bateman, Timothy K Block, Joshua L Kropp, Tyler Radke, Karen Siebers, Brian Simmons, Mary A Smith, Frances Spray-Larson, David M Warshauer
The Wisconsin State Laboratory of Hygiene challenged Wisconsin laboratories to examine their biosafety practices and improve their culture of biosafety. 103 clinical and public health laboratories completed a questionnaire-based, microbiology-focused biosafety risk assessment. Greater than 96% of respondents performed activities related to specimen processing, direct microscopic examination, and rapid non-molecular testing, while approximately 60% performed culture interpretation. Although important to assessing risk, data specific to patient occupation, symptoms, and travel history were often unavailable to the laboratory and, therefore, less contributory to microbiology biosafety risk assessment than information relative to specimen source and test requisition...
November 8, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29109595/the-role-of-hematological-indices-in-patients-with-acute-coronary-syndrome
#6
REVIEW
Jan Budzianowski, Konrad Pieszko, Paweł Burchardt, Janusz Rzeźniczak, Jarosław Hiczkiewicz
An increased systemic and local inflammation plays a key role in the pathophysiology of acute coronary syndrome (ACS). This review will discuss the role of hematological indices: white blood cells (WBC), neutrophil to lymphocyte ratio (NLR), red cell distribution width (RDW), and platelet indices, that is, platelet to lymphocyte ratio (PLR), mean platelet volume (MPV), and platelet distribution width (PDW) in the case of ACS. In recent years, a strong interest has been drawn to these indices, given that they may provide independent information on pathophysiology, risk stratification, and optimal management...
2017: Disease Markers
https://www.readbyqxmd.com/read/29074157/next-generation-sequencing-technologies-and-their-application-to-the-study-and-control-of-bacterial-infections
#7
REVIEW
John Besser, Heather A Carleton, Peter Gerner-Smidt, Rebecca L Lindsey, Eija Trees
BACKGROUND: With the decreasing cost and efficiency of next generation sequencing, the technology is rapidly introduced into clinical and public health laboratory practice. AIMS: In this review, the historical background and principles of first, second and third generation sequencing are described as are the characteristics of the most commonly used sequencing instruments. SOURCES: Peer reviewed literature, white papers and meeting reports...
October 23, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29074027/an-innovative-hvac-control-system-implementation-and-testing-in-a-vehicular-cabin
#8
Miloš Fojtlín, Jan Fišer, Jan Pokorný, Aleš Povalač, Tomáš Urbanec, Miroslav Jícha
Personal vehicles undergo rapid development in every imaginable way. However, a concept of managing a cabin thermal environment remains unchanged for decades. The only major improvement has been an automatic HVAC controller with one user's input - temperature. In this case, the temperature is often deceiving because of thermally asymmetric and dynamic nature of the cabins. As a result, the effects of convection and radiation on passengers are not captured in detail what also reduces the potential to meet thermal comfort expectations...
December 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29037432/acupuncture-for-small-animal-neurological-disorders
#9
REVIEW
Patrick Roynard, Lauren Frank, Huisheng Xie, Margaret Fowler
Modern research on traditional Chinese veterinary medicine (TCVM), including herbal medicine and acupuncture, has made evident the role of the nervous system as a cornerstone in many of the mechanisms of action of TCVM. Laboratory models and clinical research available are supportive for the use of TCVM in the management of neurologic conditions in small animals, specifically in cases of intervertebral disk disease, other myelopathies, and painful conditions. This article is meant to help guide the use of TCVM for neurologic disorders in small animals, based on available information and recommendations from experienced TCVM practitioners...
October 13, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29036543/pilot-reported-beta-blockers-identified-by-forensic-toxicology-analysis-of-postmortem-specimens
#10
Dennis V Canfield, Kurt M Dubowski, James M Whinnery, Estrella M Forster
Introduction: This study compared beta-blockers reported by pilots with the medications found by postmortem toxicology analysis of specimens received from fatal aviation accidents between 1999 and 2015. Several studies have compared drugs using the standard approach: Compare the drug found by toxicology analysis with the drug reported by the pilot. This study uniquely examined first the pilot-reported medication and then compared it to that detected by toxicology analysis. This study will serve two purposes: (i) to determine the capability of a toxicology laboratory to detect reported medications, and (ii) to identify pilots with medications below detectable limits...
September 25, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29026294/comparison-of-the-peripheral-blood-eosinophil-count-using-near-patient-testing-and-standard-automated-laboratory-measurement-in-healthy-asthmatic-and-copd-subjects
#11
Kirsty Hambleton, Clare M Connolly, Catherine Borg, Joanne H Davies, Helen P Jeffers, Richard Ek Russell, Mona Bafadhel
Near-patient testing (NPT) allows clinical decisions to be made in a rapid and convenient manner and is often cost effective. In COPD the peripheral blood eosinophil count has been demonstrated to have utility in providing prognostic information and predicting response to treatment during an acute exacerbation. For this potential to be achieved having a reliable NPT of blood eosinophil count would be extremely useful. Therefore, we investigated the use of the HemoCue(®) WBC Diff System and evaluated its sensitivity and specificity in healthy, asthmatic and COPD subjects...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28970189/impact-of-a-telehealth-program-with-voice-recognition-technology-in-patients-with-chronic-heart-failure-feasibility-study
#12
Heesun Lee, Jun-Bean Park, Sae Won Choi, Yeonyee E Yoon, Hyo Eun Park, Sang Eun Lee, Seung-Pyo Lee, Hyung-Kwan Kim, Hyun-Jai Cho, Su-Yeon Choi, Hae-Young Lee, Jonghyuk Choi, Young-Joon Lee, Yong-Jin Kim, Goo-Yeong Cho, Jinwook Choi, Dae-Won Sohn
BACKGROUND: Despite the advances in the diagnosis and treatment of heart failure (HF), the current hospital-oriented framework for HF management does not appear to be sufficient to maintain the stability of HF patients in the long term. The importance of self-care management is increasingly being emphasized as a promising long-term treatment strategy for patients with chronic HF. OBJECTIVE: The objective of this study was to evaluate whether a new information communication technology (ICT)-based telehealth program with voice recognition technology could improve clinical or laboratory outcomes in HF patients...
October 2, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28967605/-22q11-2%C3%A2-microdeletion-syndrome-analysis-of-the-care-pathway-before-the-genetic-diagnosis
#13
T Ingrao, L Lambert, M Valduga, G Bosser, E Albuisson, B Leheup
BACKGROUND: 22q11.2 deletion syndrome (22q11.2DS) is a very broad phenotypic spectrum disorder. It can affect many organs or systems. 22q11.2DS is the most common microdeletion syndrome in humans, with a prevalence ranging from one in every 2000 to one in 4000 newborns. It seems to be more prevalent than reported and under-recognized or undiagnosed because of its inherent clinical variability and heterogeneity. In France, 15,000 patients may be affected by this disease, more than half without knowing it...
November 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28947321/causes-consequences-and-management-of-sample-hemolysis-in-the-clinical-laboratory
#14
REVIEW
Laura Heireman, Pieter Van Geel, Lorenz Musger, Evelien Heylen, Wim Uyttenbroeck, Boris Mahieu
Preanalytical hemolysis of blood samples is a common problem in medical practice, especially in emergency departments. Several potential influences on sample hemolysis have been investigated, including sampling techniques, centrifugation and sample transport. In particular, the use of intravenous catheters and the vacuum sampling technique have often been demonstrated to provoke hemolysis. Other factors playing a role include the use of inappropriate puncture sites, complicated blood sampling, prolonged tourniquet application, underfilling of tubes and excessive shaking of specimens...
September 22, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28915106/making-sense-of-a-haemolysis-monitoring-and-reporting-system-a-nationwide-longitudinal-multimethod-study-of-68-australian-laboratory-participant-organisations
#15
Ling Li, Elia Vecellio, Stephanie Gay, Rebecca Lake, Mark Mackay, Leslie Burnett, Douglas Chesher, Stephen Braye, Tony Badrick, Johanna I Westbrook, Andrew Georgiou
BACKGROUND: The key incident monitoring and management systems (KIMMS) quality assurance program monitors incidents in the pre- and postanalytical phases of testing in medical laboratories. Haemolysed specimens have been found to be the most frequent preanalytical error and have major implications for patient care. The aims of this study were to assess the suitability of KIMMS for quality reporting of haemolysis and to devise a meaningful method for reporting and monitoring haemolysis...
September 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28913330/resurgence-of-diphtheria-in-north-kerala-india-2016-laboratory-supported-case-based-surveillance-outcomes
#16
Lucky Sangal, Sudhir Joshi, Shalini Anandan, Veeraraghavan Balaji, Jaichand Johnson, Asish Satapathy, Pradeep Haldar, Ramesh Rayru, Srinath Ramamurthy, Asha Raghavan, Pankaj Bhatnagar
INTRODUCTION: As part of national program, laboratory supported vaccine preventable diseases surveillance was initiated in Kerala in 2015. Mechanisms have been strengthened for case investigation, reporting, and data management. Specimens collected and sent to state and reference laboratories for confirmation and molecular surveillance. The major objective of this study is to understand the epidemiological information generated through surveillance system and its utilization for action...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28902267/-public-production-as-a-key-factor-for-access-to-antivenoms-in-the-region-of-the-americas
#17
Guillermo Temprano, Patricia Aprea, José Christian Dokmetjian
Injuries caused by venomous animals affect vast areas of Latin America, Southern Asia, Southeast Asia, sub-Saharan Africa, and Oceania, and pose a serious problem for global public health. Based on an analysis of the current panorama of global production of ophidian and arachnid antivenoms, it is concluded that they are semi-orphaned products. This is a favorable scenario in which to strengthen public laboratory production. Governments should make a political decision in this regard in the interest of equity in population health...
August 21, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28900370/utility-of-routine-laboratory-preoperative-tests-based-on-previous-results-time-to-give-up
#18
Enrique Rodríguez-Borja, Africa Corchon-Peyrallo, Gerardo Aguilar-Aguilar, Arturo Carratala-Calvo
INTRODUCTION: The usefulness and cost-effectiveness of routine laboratory preoperative tests (POTs) have been challenged recently. In fact, the American Society of Anesthesiologists (ASA) Task Force has stated that test results obtained from the medical record within 6 months of surgery generally are mostly acceptable. The aim of our study was to evaluate the degree of utility of POTs and their clinical benefit based on this recommendation. MATERIAL AND METHODS: We studied retrospectively every routine POT request from 8 randomly selected weeks in 2016...
October 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28898810/the-european-water-based-environmental-quality-standard-for-pentachlorophenol-is-not-protective-of-benthic-organisms
#19
Roberta Bettinetti, Annette Kopp-Schneider, Davide A L Vignati
Risk management of toxic substances is often based on Environmental Quality Standards (EQS) set for the water compartment, assuming they will also protect benthic organisms. In the absence of experimental data, EQS for sediments can be estimated by the equilibrium partitioning approach. The present study investigates whether this approach is protective of benthic organisms against pentachlorophenol (PCP), a legacy contaminant and EU priority substance still used in some parts of the world. Three freshwater species of invertebrates with different life cycles and feeding behaviors (the oligochaetes Lumbriculus variegatus, Tubifex tubifex and the dipteran insect Chironomus riparius) were exposed to PCP spiked sediments (2...
February 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28886171/positive-predictive-value-and-effectiveness-of-measles-case-based-surveillance-in-uganda-2012-2015
#20
Fred Nsubuga, Immaculate Ampaire, Simon Kasasa, Henry Luzze, Annet Kisakye
INTRODUCTION: Disease surveillance is a critical component in the control and elimination of vaccine preventable diseases. The Uganda National Expanded Program on Immunization strives to have a sensitive surveillance system within the Integrated Disease Surveillance and Response (IDSR) framework. We analyzed measles surveillance data to determine the effectiveness of the measles case-based surveillance system and estimate its positive predictive value in order to inform policy and practice...
2017: PloS One
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