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https://www.readbyqxmd.com/read/28809748/new-issues-on-measurement-of-b-type-natriuretic-peptides
#1
Aldo Clerico, Martina Zaninotto, Claudio Passino, Mario Plebani
The measurement of the active hormone of B-type natriuretic peptide (BNP) system actually has several analytical limitations and difficulties in clinical interpretations compared to that of inactive peptide N-terminal proBNP (NT-proBNP) because of the different biochemical and pathophysiological characteristics of two peptides and quality specifications of commercial immunoassay methods used for their measurement. Because of the better analytical characteristics of NT-proBNP immunoassays and the easier pathophysiological and clinical interpretations of variations of NT-proBNP levels in patients with heart failure (HF), some authors claimed to measure the inactive peptide NT-proBNP instead of the active hormone BNP for management of HF patients...
August 15, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28800780/a-novel-scoring-system-based-on-common-laboratory-tests-predicts-the-efficacy-of-tnf-inhibitor-and-il-6-targeted-therapy-in-patients-with-rheumatoid-arthritis-a-retrospective-multicenter-observational-study
#2
Jin Nakagawa, Yoshinobu Koyama, Atsushi Kawakami, Yukitaka Ueki, Hiroshi Tsukamoto, Takahiko Horiuchi, Shuji Nagano, Ayumi Uchino, Toshiyuki Ota, Mitsuteru Akahoshi, Koichi Akashi
BACKGROUND: Currently, although several categories of biological disease-modifying antirheumatic drugs (bDMARDs) are available, there are few data informing selection of initial treatment for individual patients with rheumatoid arthritis (RA). Therefore, tumor necrosis factor inhibitor (TNF-i) and tocilizumab (TCZ) are treated as equivalent treatments in the recent disease management recommendations. We focused on two anticytokine therapies, TCZ and TNF-i, and aimed to develop a scoring system that predicts a better treatment for each RA patient before starting an IL-6 or a TNF-i...
August 11, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28783547/impact-of-soil-organic-carbon-on-monosodium-methyl-arsenate-msma-sorption-and-species-transformation
#3
Ling Ou, Travis W Gannon, Matthew L Polizzotto
Monosodium methyl arsenate (MSMA), a common arsenical herbicide, is a major contributor of anthropogenic arsenic (As) to the environment. Uncertainty about controls on MSMA fate and the rates and products of MSMA species transformation limits effective MSMA regulation and management. The main objectives of this research were to quantify the kinetics and mechanistic drivers of MSMA species transformation and removal from solution by soil. Laboratory MSMA incubation studies with two soils and varying soil organic carbon (SOC) levels were conducted...
July 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/28757465/mini-encyclopaedia-of-the-wound-healing-opportunities-for-integrating-multi-omic-approaches-into-medical-practice
#4
Lara Stolzenburg-Veeser, Olga Golubnitschaja
Wound healing is a highly complex life-important repair process triggered by plenty of local and/or systemic organ and tissue damaging events, such as an acute surgical invasion, accidental organ and tissue damages, acute and chronic diseases, aggressive local and systemic therapeutic approaches (e.g. irradiation and systemic chemotherapy). Individual health condition determines over the quality of wound healing. Impaired wound healing, in turn, may lead, for example, to post-surgical complications frequently observed in elderly, chronic ulcers in diabetic patients, hindered and ineffective pain management, etc...
July 28, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28737658/regulation-of-clinical-xenotransplantation-time-for-a-reappraisal
#5
David K C Cooper, Richard N Pierson, Bernhard J Hering, Muhammad M Mohiuddin, Jay A Fishman, Joachim Denner, Curie Ahn, Agnes M Azimzadeh, Leo H Buhler, Peter J Cowan, Wayne J Hawthorne, Takaaki Kobayashi, David H Sachs
The continual critical shortage of organs and cells from deceased human donors has stimulated research in the field of cross-species transplantation (xenotransplantation), with the pig selected as the most suitable potential source of organs. Since the US Food and Drug Administration concluded a comprehensive review of xenotransplantation in 2003, considerable progress has been made in the experimental laboratory to improve cell and organ xenograft survival in several pig-to-nonhuman primate systems that offer the best available models to predict clinical outcomes...
August 2017: Transplantation
https://www.readbyqxmd.com/read/28732038/analysis-of-patient-data-from-laboratories-during-the-ebola-virus-disease-outbreak-in-liberia-april-2014-to-march-2015
#6
Yuki Furuse, Mosoka Fallah, Hitoshi Oshitani, Ling Kituyi, Nuha Mahmoud, Emmanuel Musa, Alex Gasasira, Tolbert Nyenswah, Bernice Dahn, Luke Bawo
An outbreak of Ebola virus disease (EVD) in Liberia began in March 2014 and ended in January 2016. Epidemiological information on the EVD cases was collected and managed nationally; however, collection and management of the data were challenging at the time because surveillance and reporting systems malfunctioned during the outbreak. EVD diagnostic laboratories, however, were able to register basic demographic and clinical information of patients more systematically. Here we present data on 16,370 laboratory samples that were tested between April 4, 2014 and March 29, 2015...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28728489/idarucizumab-for-the-treatment-of-hemorrhage-and-dabigatran-reversal-in-patients-requiring-urgent-surgery-or-procedures
#7
Ovidiu Vornicu, Anne-Sophie Larock, Anne-Sophie Dincq, Jonathan Douxfils, Jean-Michel Dogné, François Mullier, Sarah Lessire
Idarucizumab is a specific antagonist for dabigatran etexilate (DE). The recent market authorization of idarucizumab in Europe and the USA may reassure prescribers of DE, as it can increase the safety of the emergency management of patients taking this anticoagulant. However, idarucizumab use should be limited to specific indications to avoid unnecessary risks to patients and costs to healthcare systems. Areas covered: The authors provide an overview of idarucizumab development and its pharmacokinetic and pharmacodynamic properties...
July 20, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28715306/a-data-rich-longitudinal-wellness-study-for-the-digital-age-fixing-a-broken-medical-system-requires-data-about-each-patient
#8
Gustavo Glusman
We live in an age of plentiful information, collected continuously by pervasive gadgetry, distributed through digital and social networks, and mined deeply by ever-more-powerful analytics systems. And yet, one of the things we know the least about is our bodies. When it comes to our own health, we are driving blindly. Modern medicine has clearly been remarkably successful, as evidenced by continually growing life expectancies. For example, the number of people 65 and older in the United States has seen a steady increase over the last century, rising from 3...
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28712078/effects-based-spatial-assessment-of-contaminated-estuarine-sediments-from-bear-creek-baltimore-harbor-md-usa
#9
Sharon E Hartzell, Michael A Unger, Beth L McGee, Lance T Yonkos
Estuarine sediments in regions with prolonged histories of industrial activity are often laden to significant depths with complex contaminant mixtures, including trace metals and persistent organic pollutants. Given the complexity of assessing risks from multi-contaminant exposures, the direct measurement of impacts to biological receptors is central to characterizing contaminated sediment sites. Though biological consequences are less commonly assessed at depth, laboratory-based toxicity testing of subsurface sediments can be used to delineate the scope of contamination at impacted sites...
July 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28709455/barriers-and-facilitators-to-reducing-frequent-laboratory-testing-for-patients-who-are-stable-on-warfarin-a-mixed-methods-study-of-de-implementation-in-five-anticoagulation-clinics
#10
Geoffrey D Barnes, Sevan Misirliyan, Scott Kaatz, Elizabeth A Jackson, Brian Haymart, Eva Kline-Rogers, Jay Kozlowski, Gregory Krol, James B Froehlich, Anne Sales
BACKGROUND: Patients on chronic warfarin therapy require regular laboratory monitoring to safely manage warfarin. Recent studies have challenged the need for routine monthly blood draws in the most stable warfarin-treated patients, suggesting the safety of less frequent laboratory testing (up to every 12 weeks). De-implementation efforts aim to reduce the use of low-value clinical practices. To explore barriers and facilitators of a de-implementation effort to reduce the use of frequent laboratory tests for patients with stable warfarin management in nurse/pharmacist-run anticoagulation clinics, we performed a mixed-methods study conducted within a state-wide collaborative quality improvement collaborative...
July 14, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28706383/a-clinico-pathological-study-of-lupus-nephritis-based-on-the-international-society-of-nephrology-renal-pathology-society-2003-classification-system
#11
Suchitha Satish, Pallavi Deka, Manjunath Sanjeev Shetty
INTRODUCTION: Lupus nephritis (LN) is a major complication of systemic lupus erythematosus (SLE). Renal involvement is a major determinant of the prognosis of SLE. The histological classification of LN is a key factor in determining the renal survival of patients with LN. Prompt recognition and treatment of renal disease are important, as early response to therapy is correlated with better outcome and renal biopsy plays an important role in achieving this. OBJECTIVES: The objective of this study was to correlate the clinical and laboratory findings with histopathological classes of LN as per the 2003 International Society of Nephrology-Renal Pathology Society (ISN/RPS) classification system...
July 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28693453/an-account-of-the-ebola-virus-disease-outbreak-in-nigeria-implications-and-lessons-learnt
#12
Akaninyene Otu, Soter Ameh, Egbe Osifo-Dawodu, Enoma Alade, Susan Ekuri, Jide Idris
BACKGROUND: The 2014 Ebola virus disease (EVD) outbreak remains unprecedented both in the number of cases, deaths and geographic scope. The first case of EVD was confirmed in Lagos Nigeria on 23 July 2014 and spread to involve 19 laboratory-confirmed EVD cases. The EVD cases were not limited to Lagos State as Rivers State recorded 2 confirmed cases of EVD with 1 out of the 2 dying. Swift implementation of public health measures were sufficient to forestall a country -wide spread of this dreaded disease...
July 10, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28681432/computer-generated-reminders-delivered-on-paper-to-healthcare-professionals-effects-on-professional-practice-and-healthcare-outcomes
#13
REVIEW
Chantal Arditi, Myriam Rège-Walther, Pierre Durieux, Bernard Burnand
BACKGROUND: Clinical practice does not always reflect best practice and evidence, partly because of unconscious acts of omission, information overload, or inaccessible information. Reminders may help clinicians overcome these problems by prompting them to recall information that they already know or would be expected to know and by providing information or guidance in a more accessible and relevant format, at a particularly appropriate time. This is an update of a previously published review...
July 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28667812/utility-of-3d-oct-imaging-with-angiographic-co-registration-in-acute-coronary-syndrome-with-normal-or-near-normal-coronary-arteries
#14
Santiago Jesús Camacho Freire, Javier León Jiménez, Antonio Enrique Gómez Menchero, Jessica Roa Garrido, Rosa Cardenal Piris, José Francisco Díaz Fernández
The OPTIS integrated system (St. Jude Medical) is a new technology allowing the online co-registration of optical coherence tomography (OCT) images with the angiogram in the catheterization laboratory. Additionally, 3D navigation can be performed. This integration of OCT information on an angiographic roadmap could find broad application in the characterization of substrates causing acute coronary syndromes with normal or near-normal coronary arteries. The utility of OCT with co-registration for the guidance of percutaneous coronary intervention could be considerable in the management of patients with acute coronary syndromes...
July 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28651533/profiling-of-antibiotic-resistance-of-bacterial-species-recovered-from-routine-clinical-isolates-in-ethiopia
#15
Robert-Jan Ten Hove, Melaku Tesfaye, Witold Frederik Ten Hove, Mesfin Nigussie
BACKGROUND: With the alarming rise in antibiotic resistance in African countries, the need for a surveillance system in the region has become pressing. The rapid expansion of data networks makes it possible to set up healthcare applications that can be both cost-efficient and effective. Large data sets are available for assessment of current antibiotic resistance among Ethiopian patients. Based on the data-presentation, a practical approach is proposed on how diagnostic laboratories can participate remedial action against antibiotic resistance in Ethiopia...
June 26, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28647237/developing-a-chloramine-decay-index-to-understand-nitrification-a-case-study-of-two-chloraminated-drinking-water-distribution-systems
#16
Sina Moradi, Sanly Liu, Christopher W K Chow, John van Leeuwen, David Cook, Mary Drikas, Rose Amal
The management of chloramine decay and the prevention of nitrification are some of the critical issues faced by water utilities that use chloramine as a disinfectant. In this study, potential association between high performance size exclusion chromatography (HPSEC) data obtained with multiple wavelength Ultraviolet (UV) detection from two drinking water distribution systems in Australia and nitrification occurrence was investigated. An increase in the absorbance signal of HPSEC profiles with UV detection at λ=230nm between apparent molecular weights of 200 to 1000Da was observed at sampling sites that experienced rapid chloramine decay and nitrification while its absorbance signal at λ=254nm decreased...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28646808/traditional-uyghur-medicine-concepts-historical-perspective-and-modernization
#17
Adelijang Wusiman, Saifuding Abula, Mikeremu Shayibuzhati, Xiaoying Zhang
Context • Traditional Uyghur medicine (TUM) is rooted in ancient Uyghur medical theory that was developed with the combined essence of different traditional medicines, such as Han Chinese, Egyptian, ancient Greek, Arabian, Persian, and Indian medicines. Modern experimental methods and technologies for disease diagnoses have accelerated the modernization of Uyghur medicine. Objective • The research team intended to compile a comprehensive introduction to TUM and to determine the current state of research in the field to establish a basis for future modernization of Uygur medicine...
June 23, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28645053/assessment-of-imaging-in-flow-system-flowcam-for-systematic-ballast-water-management
#18
Leonardo Romero-Martínez, Cees van Slooten, Enrique Nebot, Asunción Acevedo-Merino, Louis Peperzak
Assessing the disinfection of ballast water and its compliance with international standards requires determining the size, viability, and concentration of planktonic organisms. The FlowCAM (Flow Cytometer and Microscope) is an Imaging Flow Cytometry designed to obtain the particle concentration, images, and quantitative morphologic information. The objective in this paper is to establish the basis for transforming the FlowCAM from being a laboratory analyzer into a tool for systematic monitoring of ballast water...
June 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28633405/addressing-the-key-communication-barriers-between-microbiology-laboratories-and-clinical-units-a-qualitative-study
#19
Brita Skodvin, Karina Aase, Anita Løvås Brekken, Esmita Charani, Paul Christoffer Lindemann, Ingrid Smith
Background: Many countries are on the brink of establishing antibiotic stewardship programmes in hospitals nationwide. In a previous study we found that communication between microbiology laboratories and clinical units is a barrier to implementing efficient antibiotic stewardship programmes in Norway. We have now addressed the key communication barriers between microbiology laboratories and clinical units from a laboratory point of view. Methods: Qualitative semi-structured interviews were conducted with 18 employees (managers, doctors and technicians) from six diverse Norwegian microbiological laboratories, representing all four regional health authorities...
June 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28632968/perspective-on-precision-medicine-in-oncology
#20
Tali M Johnson
The topic of precision medicine is increasingly more prevalent in the general medical literature with oncology research leading the way. Many factors, such as, availability of targeted drugs, advances in laboratory science, and improved information systems, converged to make precision medicine research possible on a large scale at the National Cancer Institute. The resultant big data will spur new kinds of research in the decades to come, but until then, all clinicians are challenged to make sense of an overabundance of information when managing individual patients...
June 20, 2017: Pharmacotherapy
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