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https://www.readbyqxmd.com/read/27910046/exosomes-based-gene-therapy-for-microrna-delivery
#1
Prabhu Mathiyalagan, Susmita Sahoo
Despite recent advances in scientific knowledge and clinical practice, cardiovascular disease management and treatment remain a major burden. While several treatment strategies using drugs and surgeries are being developed for cardiovascular manifestations, gene-based therapies hold significant promise. Recent findings from our laboratory unveiled a novel mechanism that exosomes, secreted nanovesicles from stem cells, mediate cardiac repair via transferring their unique repertoire of microRNAs (miRNA) to recipient cells in the heart...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27908978/potential-of-laboratory-execution-systems-less-to-simplify-the-application-of-business-process-management-systems-bpmss-in-laboratory-automation
#2
Sebastian Neubert, Bernd Göde, Xiangyu Gu, Norbert Stoll, Kerstin Thurow
Modern business process management (BPM) is increasingly interesting for laboratory automation. End-to-end workflow automation and improved top-level systems integration for information technology (IT) and automation systems are especially prominent objectives. With the ISO Standard Business Process Model and Notation (BPMN) 2.X, a system-independent and interdisciplinary accepted graphical process control notation is provided, allowing process analysis, while also being executable. The transfer of BPM solutions to structured laboratory automation places novel demands, for example, concerning the real-time-critical process and systems integration...
December 1, 2016: Journal of Laboratory Automation
https://www.readbyqxmd.com/read/27905644/requests-of-laboratory-tests-for-the-diagnosis-and-management-of-calcium-phosphate-disorders-in-spain
#3
María Salinas, Maite López-Garrigós, Emilio Flores, Joaquín Uris, Carlos Leiva-Salinas
BACKGROUND: Knowledge about the variability in the request of calcium-phosphate metabolism laboratory tests in primary care is important to design strategies to improve health system efficiency. AIM: To compare the inter-practice variability in calcium-phosphate metabolism laboratory tests requested by general practitioners from diverse regions across Spain. MATERIAL AND METHODS: One hundred and forty one clinical laboratories were invited to participate in an observational cross-sectional study...
August 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27886398/an-in-situ-toxicity-identification-and-evaluation-itie-water-analysis-system-laboratory-validation
#4
August J Steigmeyer, Jiamin Zhang, Jennifer M Daley, Xiaowei Zhang, G Allen Burton
It is difficult to assess the toxicity of a single stressor and establish a strong stressor-causality link when multiple stressors coexist. Toxicity Identification Evaluation (TIE) methodology uses a series of chemical and physical manipulations to fractionate compounds within a matrix and systematically identify potential toxicants. The current EPA application of TIE can provide valuable information, but often lacks ecological realism and is subject to laboratory-related artifacts. An in situ TIE Device (iTIED) was designed to assess the sources of toxicity in aquatic ecosystems...
November 25, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27866061/patterns-of-drugs-poisons-in-southern-area-of-south-korea-in-2014
#5
Eunmi Kim, Yonghoon Park, Hongil Ha, Heesun Chung
The southern area of South Korea consists of three parts; Busan, Ulsan and Gyeongsangnam-do. Busan Institute of National Forensic Service (NFS) performed about 50,000 cases throughout the southern area in 2014, occupying over 15% of total cases covered by NFS. In this study, patterns of drugs and poisons in the southern area of South Korea were investigated. The investigation was carried out by the laboratory information management system of NFS between January and December of 2014. As results, a total of 606 autopsy cases were performed by Busan Institute of NFS in 2014...
November 9, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27863724/-which-approach-of-therapeutic-education-te-for-adolescents-and-young-adults-with-cancer-experience-from-the-te-working-group-of-go-aja
#6
Nadège Corradini, Loïc Dagorne, Marielle Retailleau, Françoise Rédini, Hélène Sudour-Bonnange, Leila Gofti-Laroche, Anne Le Rhun, Nathalie Gaspar
INTRODUCTION: Therapeutic education (TE) is a practice developed over 40 years at an international level to give people with chronic illness the skills necessary to help them better manage their disease. The lengthening survival time of cancer patients as well as changes in the patient-caregiver relationship have contributed to the development of TE in oncologic diseases. Every year in France, about 1900 adolescents and young adults (15-25 years old) are diagnosed with cancer which is the second leading cause of death in this age group...
November 15, 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27863260/applications-of-dna-based-liquid-biopsy-for-central-nervous-system-neoplasms
#7
REVIEW
Joanna Wang, Chetan Bettegowda
The management of central nervous system malignancies remains reliant on histopathological analysis and neuroimaging, despite their complex genetic profile. The intratumoral heterogeneity displayed by these tumors necessitates a more sophisticated method of tumor analysis and monitoring, with the ability to assess tumors over space and time. Circulating biomarkers, including circulating tumor cells, circulating tumor DNA, and extracellular vesicles, hold promise as a type of real-time liquid biopsy able to provide dynamic information not only regarding tumor burden to monitor disease progression and treatment response, but also regarding genetic profile to enable changes in management to match a constantly evolving tumor...
November 15, 2016: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/27836776/the-use-of-clausena-anisata-in-insect-pest-control-in-africa-a-review
#8
REVIEW
L Mukandiwa, V Naidoo, D R Katerere
ETHNOPHARMACOLOGICAL RELEVANCE: Clausena anisata is used traditionally by various communities across Africa against pests such as mosquitoes, flies and weevils among others. Pests are a major cause of disease and production losses in various crop and livestock production systems in Africa. This review discusses the available information on the occurrence, chemistry, biological activity and possible commercialization of Clausena anisata with a view to see the plant species being integrated in pest management...
November 9, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27834768/design-and-implementation-of-a-prospective-adult-congenital-heart-disease-biobank
#9
Alexander R Opotowsky, Brittani Loukas, Christina Ellervik, Lilamarie E Moko, Michael N Singh, Elizabeth I Landzberg, Eric B Rimm, Michael J Landzberg
BACKGROUND: Adults with congenital heart disease (ACHD) comprise a growing, increasingly complex population. The Boston Adult Congenital Heart Disease Biobank is a program for the collection and storage of biospecimens to provide a sustainable resource for scientific biomarker investigation in ACHD. METHODS: We describe a protocol to collect, process, and store biospecimens for ACHD or associated diagnoses developed based on existing literature and consultation with cardiovascular biomarker epidemiologists...
November 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27812309/urinary-orosomucoid-validation-of-an-automated-immune-turbidimetric-test-and-its-possible-clinical-use
#10
Péter Kustán, Balázs Szirmay, Zoltán Horváth-Szalai, Andrea Ludány, Ágnes Lakatos, Diána Mühl, Per Hjort Christensen, Attila Miseta, Gábor L Kovács, Tamás Kőszegi
INTRODUCTION: Besides routine serum markers of inflammatory diseases, the diagnostic potential of selected urinary proteins has not been fully exploited yet. Former studies revealed that urinary orosomucoid (u-ORM) might have complementary information in inflammatory disorders. Our aim was to develop and validate a fully automated method for u-ORM measurements and to evaluate its potential clinical impact on systemic inflammatory diseases. MATERIALS AND METHODS: A particle-enhanced immune turbidimetric assay was validated for a Cobas 8000/c502 analyzer to determine u-ORM levels...
October 15, 2016: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/27811586/verbal-communication-during-airway-management-and-emergent-endotracheal-intubation-observations-of-team-behavior-among-multi-institutional-pediatric-intensive-care-unit-in-situ-simulations
#11
Ranna A Rozenfeld, Anna P Nannicelli, Alexandra R Brown, Walter J Eppich, Donna M Woods, Steven O Lestrud, Zehava L Noah, Jane L Holl
OBJECTIVE: To assess health-care teams' verbal communication, an observable teamwork behavior, during simulations involving pediatric emergency airway management and intubation. METHODS: We conducted video-recorded, risk-informed in situ simulations at 5 hospitals with pediatric intensive care units in the Chicago, Illinois, area. Clinicians participated in their clinical roles (eg, attending physician, bedside nurse) and had access to hospital operational systems (eg, electronic health record, medical imaging, laboratory services)...
November 2, 2016: Journal of Patient Safety
https://www.readbyqxmd.com/read/27807749/lims-and-clinical-data-management
#12
Yalan Chen, Yuxin Lin, Xuye Yuan, Bairong Shen
In order to achieve more accurate disease prevention, diagnosis, and treatment, clinical and genetic data need extensive and systematically associated study. As one way to achieve precision medicine, a laboratory information management system (LIMS) can effectively associate clinical data in a macrocosmic aspect and genomic data in a microcosmic aspect. This chapter summarizes the application of the LIMS in a clinical data management and implementation mode. It also discusses the principles of a LIMS in clinical data management, as well as the opportunities and challenges in the context of medical informatics...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27806588/source-modeling-for-monte-carlo-dose-calculation-of-ct-examinations-with-a-radiotherapy-treatment-planning-system
#13
Hans-Erik Källman, Rickard Holmberg, Jonas Andersson, Love Kull, Erik Tranéus, Anders Ahnesjö
PURPOSE: Radiation dose to patients undergoing examinations with Multislice Computed Tomography (MSCT) as well as Cone Beam Computed Tomography (CBCT) is a matter of concern. Risk management could benefit from efficient replace rational dose calculation tools. The paper aims to verify MSCT dose calculations using a Treatment Planning System (TPS) for radiotherapy and to evaluate four different variations of bow-tie filter characterizations for the beam model used in the dose calculations...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27801874/information-fusion-of-conflicting-input-data
#14
Uwe Mönks, Helene Dörksen, Volker Lohweg, Michael Hübner
Sensors, and also actuators or external sources such as databases, serve as data sources in order to realise condition monitoring of industrial applications or the acquisition of characteristic parameters like production speed or reject rate. Modern facilities create such a large amount of complex data that a machine operator is unable to comprehend and process the information contained in the data. Thus, information fusion mechanisms gain increasing importance. Besides the management of large amounts of data, further challenges towards the fusion algorithms arise from epistemic uncertainties (incomplete knowledge) in the input signals as well as conflicts between them...
October 29, 2016: Sensors
https://www.readbyqxmd.com/read/27785453/distributed-cognition-and-process-management-enabling-individualized-translational-research-the-nih-undiagnosed-diseases-program-experience
#15
Amanda E Links, David Draper, Elizabeth Lee, Jessica Guzman, Zaheer Valivullah, Valerie Maduro, Vlad Lebedev, Maxim Didenko, Garrick Tomlin, Michael Brudno, Marta Girdea, Sergiu Dumitriu, Melissa A Haendel, Christopher J Mungall, Damian Smedley, Harry Hochheiser, Andrew M Arnold, Bert Coessens, Steven Verhoeven, William Bone, David Adams, Cornelius F Boerkoel, William A Gahl, Murat Sincan
The National Institutes of Health Undiagnosed Diseases Program (NIH UDP) applies translational research systematically to diagnose patients with undiagnosed diseases. The challenge is to implement an information system enabling scalable translational research. The authors hypothesized that similar complex problems are resolvable through process management and the distributed cognition of communities. The team, therefore, built the NIH UDP integrated collaboration system (UDPICS) to form virtual collaborative multidisciplinary research networks or communities...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27778086/-on-site-detection-of-bioterrorism-relevant-agents-rapid-detection-methods-for-viruses-bacteria-and-toxins-capabilities-and-limitations
#16
Daniel Stern, Martin Richter, Livia Schrick, Peter Lasch, Kathrin Keeren, Angela Polleichtner, Karin Lemmer, Andreas Nitsche, Roland Grunow, Christian Herzog, Brigitte G Dorner, Lars Schaade
In Europe, besides the threat of terrorist attacks involving conventional methods such as explosive devices and automatic weapons, there is also a potential threat of terrorist groups using non-conventional material like biological agents in the scope of future attacks. Consequently, rapid and reliable detection systems for biological agents are being developed and tested continuously to inform crisis management. For environmental detection, a broad spectrum of different laboratory-based techniques has been developed for relevant biological agents...
October 24, 2016: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/27777902/prevalence-of-dyslipidemia-and-its-association-with-other-coronary-artery-disease-risk-factors-among-urban-population-in-southeast-of-iran-results-of-the-kerman-coronary-artery-disease-risk-factors-study-kercadrs
#17
Hamid Najafipour, Mostafa Shokoohi, Gholamreza Yousefzadeh, Behzad Sarvar Azimzadeh, Gholamreza Moshtaghi Kashanian, Mohamad Mehdi Bagheri, Ali Mirzazadeh
BACKGROUND: Despite the importance of identifying and screening dyslipidemia to prevent coronary artery diseases CAD(Coronary Artery Disease), little information is available on dyslipidemia in our large area. So the present study aimed to assess the management status of lipid abnormalities and its association with other CAD risk factors in an urban population of southeast of Iran. METHODS: This cross-sectional study was a part of the Kerman coronary artery disease risk factor study KERCADRS (Kerman coronary artery disease risk study) as a population-based, epidemiological research among 5900 individuals aged 15 to 75 years who were residents of Kerman city, the largest city in Southeast of Iran...
2016: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/27774718/a-review-of-the-public-health-management-of-shigellosis-in-australia-in-the-era-of-culture-independent-diagnostic-testing
#18
Alex Y C Tai, Marion Easton, Jess Encena, Jessica Rotty, Mary Valcanis, Benjamin P Howden, Simon Slota-Kan, Joy Gregory
OBJECTIVE: To review the national case definition for shigellosis following the introduction of culture independent diagnostic testing by clinical laboratories and provide evidence to reform jurisdictional public health practices for the management shigellosis., . METHODS: A review of all Australian jurisdictional public health guidelines for shigellosis was conducted. Victorian 2014 shigellosis data were analysed: demographics and risk factors for cases identified by conventional culture or culture-independent diagnostic methods were described...
October 23, 2016: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/27734642/current-perspective-on-use-of-noac-in-clinical-practice-in-india
#19
Jamshed J Dalal, Anil Dhall, Abhay Bhave
Oral vitamin K antagonists (VKA) such as warfarin have been the mainstay of therapy for stroke prevention in patients with non valvular atrial fibrillation (NVAF) while low-molecular-weight heparin, fondaparinux and adjusted-dose warfarin or aspirin have been routinely used for thromboembolism (VTE) prophylaxis in patients undergoing total hip or knee replacement. However, VKAs are associated with considerable limitations, including increased risk of bleeding and narrow therapeutic window. Novel oral anticoagulants (NOACs, now referred as Non Vit K dependent oral anticoagulants), including the direct thrombin inhibitor dabigatran and direct Factor Xa inhibitors such as rivaroxaban and apixaban are now approved alternatives to warfarin for prophylaxis of stroke and systemic embolic events (SEE) in patients with NVAF and treatment and prophylaxis of VTE...
April 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27734237/rfid-based-information-visibility-for-hospital-operations-exploring-its-positive-effects-using-discrete-event-simulation
#20
Daniel A Asamoah, Ramesh Sharda, Howard N Rude, Derek Doran
Long queues and wait times often occur at hospitals and affect smooth delivery of health services. To improve hospital operations, prior studies have developed scheduling techniques to minimize patient wait times. However, these studies lack in demonstrating how such techniques respond to real-time information needs of hospitals and efficiently manage wait times. This article presents a multi-method study on the positive impact of providing real-time scheduling information to patients using the RFID technology...
October 12, 2016: Health Care Management Science
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