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JOURNAL ARTICLE
LaNisha L Patterson, Caitlan D Byerly, Regina Solomon, Nicholas Pittner, Duc Cuong Bui, Jignesh Patel, Jere W McBride
Ehrlichia chaffeensis has evolved multiple strategies to evade innate defenses of the mononuclear phagocyte. Recently, we reported the E. chaffeensis tandem repeat protein (TRP)120 effector functions as a Notch ligand mimetic and a ubiquitin ligase that degrades the nuclear tumor suppressor, F-box and WD repeat domain-containing 7, a negative regulator of Notch. The Notch intracellular domain (NICD) is known to inhibit apoptosis primarily by interacting with X-linked inhibitor of apoptosis <u>p</u>rotein (XIAP) to prevent degradation...
August 18, 2023: Infection and Immunity
#22
JOURNAL ARTICLE
Nicolas Fissolo, Laura Calvo-Barreiro, Herena Eixarch, Ursula Boschert, Luisa M Villar, Lucienne Costa-Frossard, Mireia Ferrer, Alex Sanchez, Eva Borràs, Eduard Sabidó, Carmen Espejo, Xavier Montalban, Manuel Comabella
INTRODUCTION: Little is known about the molecular profiling associated with the effect of cladribine in patients with multiple sclerosis (MS). Here, we aimed first to characterize the transcriptomic and proteomic profiles induced by cladribine in blood cells, and second to identify potential treatment response biomarkers to cladribine in patients with MS. METHODS: Gene, protein and microRNA (miRNA) expression profiles were determined by microarrays (genes, miRNAs) and mass spectrometry (proteins) in peripheral blood mononuclear cells (PBMCs) from MS patients after in vitro treatment with cladribine in its active and inactive forms...
2023: Frontiers in Immunology
#23
JOURNAL ARTICLE
Cuiling Wu, Shengchao Ma, Bingru Zhao, Chongkai Qin, Yujiang Wu, Jiang Di, Langda Suo, Xuefeng Fu
BACKGROUND: The adaptive evolution of plateau indigenous animals is a current research focus. However, phenotypic adaptation is complex and may involve the interactions between multiple genes or pathways, many of which remain unclear. As a kind of livestock with important economic value, cashmere goat has a high ability of plateau adaptation, which provides us with good materials for studying the molecular regulation mechanism of animal plateau adaptation. RESULTS: In this study, 32 Jiangnan (J) and 32 Tibetan (T) cashmere goats were sequenced at an average of 10...
August 1, 2023: BMC Genomics
#24
JOURNAL ARTICLE
Vittoria Bisutti, Núria Mach, Diana Giannuzzi, Alice Vanzin, Emanuele Capra, Riccardo Negrini, Maria Elena Gelain, Alessio Cecchinato, Paolo Ajmone-Marsan, Sara Pegolo
BACKGROUND: Subclinical intramammary infection (IMI) represents a significant problem in maintaining dairy cows' health. Disease severity and extent depend on the interaction between the causative agent, environment, and host. To investigate the molecular mechanisms behind the host immune response, we used RNA-Seq for the milk somatic cells (SC) transcriptome profiling in healthy cows (n = 9), and cows naturally affected by subclinical IMI from Prototheca spp. (n = 11) and Streptococcus agalactiae (S...
July 5, 2023: Journal of Animal Science and Biotechnology
#25
JOURNAL ARTICLE
Talha Rafiq, Jennifer C Stearns, Meera Shanmuganathan, Sandi M Azab, Sonia S Anand, Lehana Thabane, Joseph Beyene, Natalie C Williams, Katherine M Morrison, Koon K Teo, Philip Britz-McKibbin, Russell J de Souza
Evidence supports a complex interplay of gut microbiome and host metabolism as regulators of obesity. The metabolic phenotype and microbial metabolism of host diet may also contribute to greater obesity risk in children early in life. This study aimed to identify features that discriminated overweight/obese from normal weight infants by integrating gut microbiome and serum metabolome profiles. This prospective analysis included 50 South Asian children living in Canada, selected from the SouTh Asian biRth cohorT (START)...
June 2023: Heliyon
#26
JOURNAL ARTICLE
Miaomiao Sun, Ke Li, Xiao Li, Huajun Wang, Li Li, Guangying Zheng
BACKGROUND: As one of the early discovered long non-coding RNAs (lncRNA), taurine upregulation gene 1 (TUG1) has been widely expressed in a variety of tumors. Moreover, it promotes cell proliferation, differentiation, apoptosis, and migration. However, our understanding of its importance in the pathogenesis of cataracts remains limited. This study aimed to explore the mechanism by which lncRNA TUG1 mediates lens epithelial cell apoptosis in age-related cataracts (ARC) by regulating the microRNAs (miR-29b)/second mitochondria-derived activator of caspases axis, and to identify more non-surgical strategies for cataract treatment...
April 26, 2023: Chinese Medical Journal
#27
JOURNAL ARTICLE
Lynne Rosenberg, Cuining Liu, Rinku Sharma, Cheyret Wood, Carrie A Vyhlidal, Roger Gaedigk, Alvin T Kho, John P Ziniti, Juan C Celedón, Kelan G Tantisira, Scott T Weiss, Michael J McGeachie, Katerina Kechris, Sunita Sharma
Intrauterine smoke (IUS) exposure during early childhood has been associated with a number of negative health consequences, including reduced lung function and asthma susceptibility. The biological mechanisms underlying these associations have not been established. MicroRNAs regulate the expression of numerous genes involved in lung development. Thus, investigation of the impact of IUS on miRNA expression during human lung development may elucidate the impact of IUS on post-natal respiratory outcomes. We sought to investigate the effect of IUS exposure on miRNA expression during early lung development...
April 23, 2023: International Journal of Molecular Sciences
#28
JOURNAL ARTICLE
Mansour Nawasreh, Lubna Tahtamouni
Since the discovery of cephalostatins, which have shown remarkable activity against human cancer cells, they have attracted the attention of researchers to target the synthesis of such impressive, complicated molecules using the green desymmetrization approach. In the current review, we report the progress in the desymmetrization of symmetrical bis-steroidal pyrazines (BSPs) as an approach toward potentially active anti-cancer agents, namely cephalostatins/ ritterazines. The achievement of synthesizing a gram-scaled prodrug with comparable activity to the potent natural cephalostatins using green methods is our primary target...
May 8, 2023: Current Medicinal Chemistry
#29
JOURNAL ARTICLE
Roderick C Slieker, Louise A Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Ayşim Güneş, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N Giordano, Mikael Åkerlund, Emma Ahlqvist, Ashfaq Ali, Karina Banasik, Søren Brunak, Marko Barovic, Gerard A Bouland, Frédéric Burdet, Mickaël Canouil, Iulian Dragan, Petra J M Elders, Celine Fernandez, Andreas Festa, Hugo Fitipaldi, Phillippe Froguel, Valborg Gudmundsdottir, Vilmundur Gudnason, Mathias J Gerl, Amber A van der Heijden, Lori L Jennings, Michael K Hansen, Min Kim, Isabelle Leclerc, Christian Klose, Dmitry Kuznetsov, Dina Mansour Aly, Florence Mehl, Diana Marek, Olle Melander, Anne Niknejad, Filip Ottosson, Imre Pavo, Kevin Duffin, Samreen K Syed, Janice L Shaw, Over Cabrera, Timothy J Pullen, Kai Simons, Michele Solimena, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W Franks, Gareth E Lim, Jennifer Estall, Mark Ibberson, Joline W J Beulens, Leen M 't Hart, Ewan R Pearson, Guy A Rutter
We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol species, and lowered sphingomyelin 42:2;2 levels are predictive of faster progression towards insulin requirement. Of ~1,300 proteins examined in two cohorts, levels of GDF15/MIC-1, IL-18Ra, CRELD1, NogoR, FAS, and ENPP7 are associated with faster progression, whilst SMAC/DIABLO, SPOCK1 and HEMK2 predict lower progression rates...
May 3, 2023: Nature Communications
#30
JOURNAL ARTICLE
Brian Farneti, Iuliia Khomenko, Matteo Ajelli, Karen Elizabeth Wells, Emanuela Betta, Eugenio Aprea, Lara Giongo, Franco Biasioli
The application of direct-injection mass spectrometric (DI-MS) techniques, like Proton Transfer Reaction Time of Flight Mass Spectrometry (PTR-ToF-MS) has been suggested as a reliable phenotyping tool for fruit volatilome assessment in both genetic and quality-related studies. In this study the complexity of raspberry aroma was investigated by a comprehensive untargeted VOC analysis, done by combining SPME-GC-MS and PTR-ToF-MS assessments with multi-block discriminant analysis using the DIABLO mixOmics framework...
2023: Frontiers in Molecular Biosciences
#31
JOURNAL ARTICLE
Getinet M Adinew, Samia Messeha, Equar Taka, Shade A Ahmed, Karam F A Soliman
BACKGROUND/AIM: Compared to other breast cancer types, triple-negative breast cancer (TNBC) has historically had few treatment alternatives. Therefore, exploring and pinpointing potentially implicated genes could be used for treating and managing TNBC. By doing this, we will provide essential data to comprehend how the genes are involved in the apoptotic pathways of the cancer cells to identify potential therapeutic targets. Analysis of a single genetic alteration may not reveal the pathogenicity driving TNBC due to the high genomic complexity and heterogeneity of TNBC...
2023: Cancer Genomics & Proteomics
#32
JOURNAL ARTICLE
Mohd Mukrish Mohd Hanafi, Harisun Yaakob, Simon Gibbons, Jose M Prieto
This study aims to evaluate the in vitro cytotoxic and anti-migratory effects of Marantodes pumilum Blume Kuntze plant extracts on prostate cancer cells, identify the active compound/s, and characterize their mechanism of action. The crude methanolic extract was partitioned into n -hexane (MPh), chloroform (MPc), and aqueous (MPa) extracts. Antiproliferative fractions (IC50 < 30 μg/mL based on SRB staining of LNCaP and PC3 cell lines) were further fractionated. Active compound/s were identified using spectroscopic methods...
April 6, 2023: Plants (Basel, Switzerland)
#33
REVIEW
Varda Shoshan-Barmatz, Tasleem Arif, Anna Shteinfer-Kuzmine
Apoptosis is a process of programmed cell death in which a cell commits suicide while maintaining the integrity and architecture of the tissue as a whole. Apoptosis involves activation of one of two major pathways: the extrinsic pathway, where extracellular pro-apoptotic signals, transduced through plasma membrane death receptors, activate a caspase cascade leading to apoptosis. The second, the intrinsic apoptotic pathway, where damaged DNA, oxidative stress, or chemicals, induce the release of pro-apoptotic proteins from the mitochondria, leading to the activation of caspase-dependent and independent apoptosis...
June 2023: Apoptosis: An International Journal on Programmed Cell Death
#34
JOURNAL ARTICLE
Qiao Chen, Shugen Qu, Zhenzhen Liang, Yi Liu, Huajian Chen, Shumei Ma, Xiaodong Liu
Despite the wide application of radiotherapy in HCC, radiotherapy efficacy is sometimes limited due to radioresistance. Although radioresistance is reported with high glycolysis, the underlying mechanism between radioresistance and cancer metabolism, as well as the role of cathepsin H (CTSH) within it, remain unclear. In this study, tumor-bearing models and HCC cell lines were used to observe the effect of CTSH on radioresistance. Proteome mass spectrometry, followed by enrichment analysis, were used to investigate the cascades and targets regulated by CTSH...
March 9, 2023: International Journal of Molecular Sciences
#35
JOURNAL ARTICLE
Somayeh Tavakoli, Loghman Firoozpour, Jamshid Davoodi
Drug resistance is one of the most important obstacles in effective cancer therapy triggered through various mechanisms. One of these mechanisms is caused by the upregulation of Inhibitor of Apoptosis Proteins (IAPs). IAPs, inhibit apoptosis through direct and/or indirect caspase inhibition, which themselves are antagonized by an endogenous protein called Second Mitochondrial-derived Activator of Caspases, Smac/Diablo, mediated by the presence of a tetrapeptide IAP binding motif at its N-terminus. Accordingly, Smac-based peptides are under intense investigation as anti-cancer drugs and have reached Phase 2 clinical trials, although, Smac based peptides or mimetics alone have not been effective as anti-cancer agents...
March 6, 2023: Biochemical and Biophysical Research Communications
#36
REVIEW
Jose M Prieto, Mohd Mukrish Mohd Hanafi
Prostate cancer (PCa) remains both a global health burden and a scientific challenge. We present a review of the molecular targets driving current drug discovery to fight this disease. Moreover, the preventable nature of most PCa cases represents an opportunity for phytochemicals as chemopreventive when adequately integrated into nutritional interventions. With a renovated interest in natural remedies as a commodity and their essential role in cancer drug discovery, Malaysia is looking towards capitalizing on its mega biodiversity, which includes the oldest rainforest in the world and an estimated 1200 medicinal plants...
February 9, 2023: Current Issues in Molecular Biology
#37
LaNisha L Patterson, Caitlan D Byerly, Regina Solomon, Nicholas Pittner, Duc Cuong Bui, Jignesh Patel, Jere W McBride
UNLABELLED: Ehrlichia chaffeensis has evolved multiple strategies to evade innate defenses of the mononuclear phagocyte. Recently, we reported the E. chaffeensis TRP120 effector functions as a Notch ligand mimetic and a ubiquitin ligase that degrades the nuclear tumor suppressor, F-box and WD repeat domain-containing 7 (FBW7), a negative regulator of Notch. The Notch receptor intracellular domain (NICD) is known to inhibit apoptosis primarily by interacting with X-linked inhibitor of apoptosis protein (XIAP) to prevent degradation...
January 7, 2023: bioRxiv
#38
JOURNAL ARTICLE
Xiangyu Wang, Xiaofei Guo, Xiaoyun He, Ran Di, Xiaosheng Zhang, Jinlong Zhang, Mingxing Chu
The litter size and ovulation rate are different among ewes of different FecB genotypes in Small Tail Han sheep. These variants in reproductive phenotypes may be regulated by hormones released by the hypothalamic-pituitary-ovarian axis. However, there have been few reports on the hypothalamus regarding regulating an increase in ovulation in sheep with FecB mutation at different estrous stages. Thus, we examined the abundance of hypothalamus tissue protein profiles of six FecB mutant homozygous (BB) and six wild-type (WW) ewes at the luteal and follicular phases...
December 30, 2022: Biology
#39
JOURNAL ARTICLE
Andrea Bonicelli, Hayley L Mickleburgh, Alberto Chighine, Emanuela Locci, Daniel J Wescott, Noemi Procopio
The combined use of multiple omics allows to study complex interrelated biological processes in their entirety. We applied a combination of metabolomics, lipidomics and proteomics to human bones to investigate their combined potential to estimate time elapsed since death (i.e., the postmortem interval [PMI]). This 'ForensOMICS' approach has the potential to improve accuracy and precision of PMI estimation of skeletonized human remains, thereby helping forensic investigators to establish the timeline of events surrounding death...
December 30, 2022: ELife
#40
REVIEW
Rachel P Sarnoff, Ravi R Bhatt, Vadim Osadchiy, Tien Dong, Jennifer S Labus, Lisa A Kilpatrick, Zixi Chen, Vishvak Subramanyam, Yurui Zhang, Benjamin M Ellingson, Bruce Naliboff, Lin Chang, Emeran A Mayer, Arpana Gupta
Alterations of the brain-gut-microbiome system (BGM) have been implicated in the pathophysiology of irritable bowel syndrome (IBS), yet bowel habit-specific alterations have not been elucidated. In this cross-sectional study, we apply a systems biology approach to characterize BGM patterns related to predominant bowel habit. Fecal samples and resting state fMRI were obtained from 102 premenopausal women (36 constipation-predominant IBS (IBS-C), 27 diarrhea-predominant IBS (IBS-D), 39 healthy controls (HCs))...
December 17, 2022: Neuropharmacology
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