keyword
MENU ▼
Read by QxMD icon Read
search

Sprint hypertension

keyword
https://www.readbyqxmd.com/read/28331987/hypertension-up-to-date-sprint-to-spyral
#1
REVIEW
Saarraaken Kulenthiran, Sebastian Ewen, Michael Böhm, Felix Mahfoud
Hypertension is the most common chronic cardiovascular condition with increasing prevalence all over the world. Treatment of patients at risk requires a multimodal therapeutic concept to adjust blood pressure, including systematic identification of secondary causes of hypertension or pseudo-resistance, lifestyle modification, polypharmacy, and as well as accompanying risk factors and comorbidities. The present review discusses recent studies on patients with increased cardiovascular risk potentially influencing future treatment strategies...
March 22, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28267687/hypertension-s-3-dilemmas-and-3-solutions-pharmacology-of-the-kidney-in-hypertension
#2
William A Pettinger
The Hypertension Community has 3 conflicting dilemmas: a goal systolic pressure of 120 mm Hg or less (the SPRINT Trials), 40% of our 60,000,000 hypertensives still sustain blood pressures above 140/90 mm Hg, and our most potent antihypertensive drug minoxidil sits on the sidelines, imprisoned in the Food and Drug Administration's Black Box designation. My solutions to these dilemmas are: (1) review of the facts of our most potent antihypertensive drug minoxidil which is essentially free of toxicity, (2) treatment focus on the fundamental cause of high blood pressure, that is excess dietary sodium and, (3) prevention of, and/or reversal of, the fundamental mechanism of worsening hypertension, arteriolar hypertrophy...
March 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28185469/hypertension-treatment-in-the-elderly-a-sprint-to-the-finish
#3
Christine Parsons, Farouk Mookadam, Martina Mookadam
No abstract text is available yet for this article.
March 2017: Future Cardiology
https://www.readbyqxmd.com/read/28166324/effect-of-intensive-blood-pressure-control-on-gait-speed-and-mobility-limitation-in-adults-75-years-or-older-a-randomized-clinical-trial
#4
Michelle C Odden, Carmen A Peralta, Dan R Berlowitz, Karen C Johnson, Jeffrey Whittle, Dalane W Kitzman, Srinivasan Beddhu, John W Nord, Vasilios Papademetriou, Jeff D Williamson, Nicholas M Pajewski
Importance: Intensive blood pressure (BP) control confers a benefit on cardiovascular morbidity and mortality; whether it affects physical function outcomes is unknown. Objective: To examine the effect of intensive BP control on changes in gait speed and mobility status. Design, Setting, and Participants: This randomized, clinical trial included 2636 individuals 75 years or older with hypertension and no history of type 2 diabetes or stroke who participated in the Systolic Blood Pressure Intervention Trial (SPRINT)...
February 6, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28163557/experts-provide-a-glimpse-of-the-new-post-sprint-era-of-hypertension
#5
Susan L Worley
In advance of the new guidelines being published this year, the author discusses treatment targets, diagnostics, and public policy with three hypertension experts.
February 2017: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/28161697/in-the-wake-of-systolic-blood-pressure-intervention-trial-new-targets-for-improving-hypertension-management-in-chronic-kidney-disease
#6
Crystal C Tyson, Thomas M Coffman
Systolic Blood Pressure Intervention Trial (SPRINT) was a multicenter randomized controlled trial showing the significant benefit of intensive reduction of blood pressure to a target of 120 mm Hg in individuals with hypertension and elevated cardiovascular risk. Because SPRINT includes the largest cohort of adults with chronic kidney disease (CKD) to be prospectively studied in a hypertension intervention trial, it has particular relevance to the field of nephrology. Here, we review the findings of SPRINT and assess their potential impact on guidelines for treatment of hypertension in patients with CKD...
February 4, 2017: Nephron
https://www.readbyqxmd.com/read/28124381/broad-spectrum-health-improvements-with-one-year-of-soccer-training-in-inactive-mildly-hypertensive-middle-aged-women
#7
P Krustrup, M-B Skoradal, M B Randers, P Weihe, J Uth, J Mortensen, M Mohr
The study tested the hypothesis that long-term soccer training has positive impact on cardiovascular profile, body composition, bone health, and physical capacity in inactive, pre-menopausal women with mild hypertension. The study applied a randomized controlled design in which physically inactive middle-aged women were separated into a soccer training group (n=19; SOC) and a control group (n=12; CON). SOC performed 128±29 (±SD) one-h small-sided soccer training sessions over one year. Blood pressure, body composition, blood lipid profile, and fitness level were determined pre- and post-intervention...
January 25, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28118620/association-of-albuminuria-and-estimated-glomerular-filtration-rate-with-functional-performance-measures-in-older-adults-with-chronic-kidney-disease
#8
Dawn F Wolfgram, Katelyn Garcia, Greg Evans, Sara Zamanian, Rocky Tang, Thomas Wiegmann, Rajeev Sharma, Ruth Campbell, Jeff Whittle
BACKGROUND: Chronic kidney disease (CKD) is increasingly common and disproportionately affects older adults. The contribution of kidney disease to the functional impairment noted in the elderly CKD population is unclear. METHODS: This is a cross-sectional analysis of a hypertensive cohort of people aged ≥75 years from the Systolic Blood Pressure Intervention Trial. We evaluated estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) as predictors of 3 measures of functional status: EuroQol-5 Dimensional (EQ-5D) score, Falls Efficacy Scale (FES) score, and gait speed...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28109971/optimal-systolic-blood-pressure-target-after-sprint-insights-from-a-network-meta-analysis-of-randomized-trials
#9
Sripal Bangalore, Bora Toklu, Eugenia Gianos, Arthur Schwartzbard, Howard Weintraub, Gbenga Ogedegbe, Franz H Messerli
BACKGROUND: The optimal on-treatment blood pressure (BP) target has been a matter of debate. The recent SPRINT trial showed significant benefits of a BP target of <120 mm Hg, albeit with an increase in serious adverse effects related to low BP. METHODS: PubMed, EMBASE, and CENTRAL were searched for randomized trials comparing treating with different BP targets. Trial arms were grouped into 5 systolic BP target categories: 1) <160 mm Hg, 2) <150 mm Hg, 3) <140 mm Hg, 4) <130 mm Hg, and 5) <120 mm Hg...
January 19, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28106149/blood-pressure-reduction-in-diabetes-lessons-from-accord-sprint-and-empa-reg-outcome
#10
REVIEW
Pantelis A Sarafidis, Antonios A Lazaridis, Gema Ruiz-Hurtado, Luis M Ruilope
In patients with diabetes mellitus, the presence of hypertension substantially increases the risk of cardiovascular events, and reductions in blood pressure (BP) can reduce cardiovascular morbidity and mortality. Following evidence from trials randomizing patients to diastolic BP levels, previous guidelines recommended an office BP target of <130/80 mmHg in individuals with diabetes mellitus. However, the evidence for this systolic BP (SBP) target was derived from observational studies. When the results of the ACCORD-BP study showed that those individuals with diabetes mellitus and a target BP of <120 mmHg had a cardiovascular risk that is similar to those with <140 mmHg, all guidelines returned to a recommended SBP of <140 mmHg...
January 20, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28090762/use-of-ace-inhibition-and-blood-pressure-management-in-deferring-dialysis-initiation
#11
Lucia Del Vecchio, Ugo Teatini, Francesco Locatelli
Elevated blood pressure is one of the most significant risk factor for the development of chronic kidney disease (CKD); its treatment is a milestone in CKD management. While it is accepted that a stricter blood pressure control is indicated in patients with proteinuria or microalbuminuria, the exact degree of blood pressure reduction to be obtained in CKD patients is still under debate. Following more recent interpretation of old trials, a BP target for <140/90 mmHg is suggested for non-proteinuric CKD patients...
June 2017: Panminerva Medica
https://www.readbyqxmd.com/read/27981434/novel-pathophysiological-mechanisms-in-hypertension
#12
Rohan Samson, Andrew Lee, Sean Lawless, Robert Hsu, Gary Sander
Hypertension is the most common disease affecting humans and imparts a significant cardiovascular and renal risk to patients. Extensive research over the past few decades has enhanced our understanding of the underlying mechanisms in hypertension. However, in most instances, the cause of hypertension in a given patient continues to remain elusive. Nevertheless, achieving aggressive blood pressure goals significantly reduces cardiovascular morbidity and mortality, as demonstrated in the recently concluded SPRINT trial...
December 16, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27926691/on-treatment-blood-pressures-of-older-hypertensive-patients-in-canada-implications-for-systolic-blood-pressure-intervention-trial
#13
Jiri George Fodor, Penelope Baker, Li Chen, Frans H H Leenen
OBJECTIVE: The therapeutic target level for the blood pressure (BP) on antihypertensive drug treatment in older hypertensive patients is still extensively debated. We assessed the achieved BP levels in older treated hypertensive patients in a representative sample of the population. DESIGN: During the 2006 Ontario Survey on the Prevalence and Control of Hypertension, BP (using the SPRINT protocol) and treatment data were collected in 2551 respondents from a random and representative sample of the adult (20-79 years) population...
March 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27919826/should-blood-pressure-goal-be-individualized-in-hypertensive-patients
#14
REVIEW
Alexandra Yannoutsos, Rania Kheder-Elfekih, Jean-Michel Halimi, Michel E Safar, Jacques Blacher
The aim of the present review is to consider the clinical relevance of individualized blood pressure (BP) goal under treatment in hypertensive patients according to their age, comorbidities or established cardiovascular (CV) disease. Evidence from large-scale randomized trials to support a lower BP goal, as initially recommended by guidelines in high-risk hypertensive patients, were lacking. Recently, the randomized intervention SPRINT trial studied two treatment targets for systolic BP (120mm Hg versus 140mm Hg in the intensive and standard treatment group, respectively) among high-risk hypertensive patients, without diabetes and without a history of prior stroke...
December 2, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27884231/guidelines-for-the-management-of-hypertension
#15
REVIEW
Aram V Chobanian
This article summarizes pertinent data from clinical trials on the effects of antihypertensive therapy on cardiovascular complications. Prior definitions of hypertension and blood pressure goals of therapy are discussed, and differences between national and international guidelines on such goals are summarized. The results of the SPRINT study are summarized, and the impact of this study on future goals of treatment is discussed. New recommendations are provided on blood pressure goals, and the effects such goals might have on clinical practice are discussed...
January 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/27865822/ambulatory-blood-pressure-in-hypertensive-patients-with-inclusion-criteria-for-the-sprint-trial
#16
Alejandro de la Sierra, José R Banegas, Juan A Divisón, Manuel Gorostidi, Ernest Vinyoles, Juan J de la Cruz, Julián Segura, Luis M Ruilope
We aimed to characterize 24-hour blood pressure (BP) values and categories in patients with inclusion/exclusion criteria of the Systolic Blood Pressure Intervention (SPRINT) trial from the Spanish ABPM Registry. We selected patients older than 50 years, with office systolic BP (SBP) above 130 mm Hg and at high cardiovascular risk, but without diabetes, previous stroke, or symptomatic heart failure. Ambulatory BP was compared among BP categories. A total of 39,132 patients (34%) fulfilled inclusion criteria of SPRINT trial...
December 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27862904/baseline-blood-pressure-control-in-hispanics-characteristics-of-hispanics-in-the-systolic-blood-pressure-intervention-trial
#17
Carlos J Rodriguez, Carolyn H Still, Katelyn R Garcia, Lynne Wagenknecht, Suzanne White, Jeffrey T Bates, Margareth V Del Cid, Michael Lioudis, Nieves Lopez Barrera, Abel Moreyra, Henry Punzi, Robert J Ringer, William C Cushman, Gabriel Contreras, Karen Servilla, Michael Rocco
The Systolic Blood Pressure Intervention Trial (SPRINT) tested whether a systolic blood pressure (SBP) value <120 mm Hg reduces adverse clinical outcomes compared with the goal of <140 mm Hg. Here the authors describe the baseline characteristics of Hispanic participants in SPRINT. Nondiabetic hypertensive patients 50 years and older with SBP 130-180 mm Hg taking zero to four blood pressure (BP) medications were enrolled from the mainland United States and Puerto Rico. Cross-sectional, bivariate analysis was employed comparing sociodemographic and clinical factors in Hispanics vs non-Hispanics...
February 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/27849563/effect-of-intensive-versus-standard-clinic-based-hypertension-management-on-ambulatory-blood-pressure-results-from-the-sprint-systolic-blood-pressure-intervention-trial-ambulatory-blood-pressure-study
#18
Paul E Drawz, Nicholas M Pajewski, Jeffrey T Bates, Natalie A Bello, William C Cushman, Jamie P Dwyer, Lawrence J Fine, David C Goff, William E Haley, Marie Krousel-Wood, Andrew McWilliams, Dena E Rifkin, Yelena Slinin, Addison Taylor, Raymond Townsend, Barry Wall, Jackson T Wright, Mahboob Rahman
The effect of clinic-based intensive hypertension treatment on ambulatory blood pressure (BP) is unknown. The goal of the SPRINT (Systolic Blood Pressure Intervention Trial) ambulatory BP ancillary study was to evaluate the effect of intensive versus standard clinic-based BP targets on ambulatory BP. Ambulatory BP was obtained within 3 weeks of the 27-month study visit in 897 SPRINT participants. Intensive treatment resulted in lower clinic systolic BP (mean difference between groups=16.0 mm Hg; 95% confidence interval, 14...
January 2017: Hypertension
https://www.readbyqxmd.com/read/27842710/-hypertension-and-coronary-artery-disease-new-concept
#19
G Lefèvre, E Puymirat
Hypertension is the most important preventable cause of heart disease and stroke worldwide. More than 1 in 5 adults worldwide have raised blood pressure - a condition that causes around half of all deaths from stroke and heart disease. Complications from hypertension account for 9.4 million deaths worldwide every year. During the last decade, the association between blood pressure reduction from above-normal initial values and cardiovascular-risk has been documented in a large number of randomized trials...
February 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/27771852/threshold-and-target-for-blood-pressure-lowering-in-the-elderly
#20
Guido Grassi, Fosca Quarti-Trevano, Anna Casati, Raffaella Dell'Oro
PURPOSE OF REVIEW: Detection of elevated blood pressure values in elderly patients represents a common clinical condition associated with an increased cardiovascular risk. This has been shown to be the case in both systodiastolic and isolated systolic hypertension as well. However, despite the evidence of the benefits of the blood pressure lowering intervention in terms of reduction of cardiovascular morbidity and mortality, at least two issues related to antihypertensive drug treatment in aged individuals are still undefined: (1) the blood pressure threshold at which antihypertensive drug should be initiated and (2) the blood pressure goals of the therapeutic intervention...
December 2016: Current Atherosclerosis Reports
keyword
keyword
91675
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"