Peter Saliba-Gustafsson, Johanne M Justesen, Amanda Ranta, Disha Sharma, Ewa Bielczyk-Maczynska, Jiehan Li, Laeya A Najmi, Maider Apodaka, Patricia Aspichueta, Hanna M Björck, Per Eriksson, Anders Franco-Cereceda, Mike Gloudemans, Endrina Mujica, Marcel den Hoed, Themistocles L Assimes, Thomas Quertermous, Ivan Carcamo-Orive, Chong Y Park, Joshua W Knowles
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver pathology in western countries, with serious public health consequences. Efforts to identify causal genes for NAFLD have been hampered by the relative paucity of human data from gold-standard magnetic resonance quantification of hepatic fat. To overcome insufficient sample size, genome-wide association studies using NAFLD surrogate phenotypes have been used, but only a small number of loci have been identified to date...
February 4, 2024: medRxiv