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Toxic epidermal necrolysis

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https://www.readbyqxmd.com/read/29340540/toxic-epidermal-necrolysis-a-paradigm-of-critical-illness
#1
Alfonso Estrella-Alonso, José Antonio Aramburu, Mercedes Yolanda González-Ruiz, Lucía Cachafeiro, Manuel Sánchez Sánchez, José A Lorente
Toxic epidermal necrolysis is an adverse immunological skin reaction secondary in most cases to the administration of a drug. Toxic epidermal necrolysis, Stevens-Johnson syndrome, and multiform exudative erythema are part of the same disease spectrum. The mortality rate from toxic epidermal necrolysis is approximately 30%. The pathophysiology of toxic epidermal necrolysis is similar in many respects to that of superficial skin burns. Mucosal involvement of the ocular and genital epithelium is associated with serious sequelae if the condition is not treated early...
October 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/29322835/toxic-epidermal-necrolysis-versus-cutaneous-graft-versus-host-disease-in-a-hematopoietic-stem-cell-transplant-recipient-the-role-of-elafin
#2
Alessandra Chen, Kevin Chao, Lina Rodriguez, William Munday, Scott Worswick
No abstract text is available yet for this article.
January 11, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29316113/drug-induced-liver-injury-is-frequently-associated-with-severe-cutaneous-adverse-drug-reactions-experience-from-two-australian-tertiary-hospitals
#3
Wendy C Fang, Nikki R Adler, Linda V Graudins, Caitlin Goldblatt, Michelle Sy Goh, Stuart K Roberts, Jason A Trubiano, Ar Kar Aung
BACKGROUND: Drug-induced liver injury can be associated with certain cutaneous adverse drug reactions. AIMS: We aim to demonstrate the prevalence of drug-induced liver injury in patients with cutaneous adverse drug reactions. Severity and patterns of liver injury, risk factors, causal medications and outcomes are also examined. METHODS: A retrospective cohort study of patients with cutaneous adverse drug reactions was conducted across two hospitals in Australia...
January 8, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29315761/incidence-outcomes-and-resource-use-in-children-with-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#4
James W Antoon, Jennifer L Goldman, Brian Lee, Alan Schwartz
BACKGROUND/OBJECTIVES: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening cutaneous reactions, typically to drugs or infection. The incidence and outcomes of these conditions in children are unknown. The objective of this study was to report the overall burden of Stevens-Johnson syndrome and toxic epidermal necrolysis in children in the United States. METHODS: We performed a retrospective cohort analysis of children and adolescents younger than 18 years of age using the 2009 and 2012 Kids' Inpatient Database...
January 9, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29314302/toxic-epidermal-necrolysis-a-review-of-20-years-of-data
#5
Mark C Marchitto, Sarah Sung, Judy Doong, Anna L Chien
Toxic epidermal necrolysis (TEN) is a rare, yet life-threatening immune-mediated mucocutaneous disorder often occurring in the context of a newly administered medication. The cutaneous manifestations are characterized by extensive epidermal detachment, mucosal surface erosion, and multi-organ damage (1-2). This article is protected by copyright. All rights reserved.
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29310768/sjs-ten-2017-building-multidisciplinary-networks-to-drive-science-and-translation
#6
REVIEW
Katie D White, Riichiro Abe, Michael Ardern-Jones, Thomas Beachkofsky, Charles Bouchard, Bruce Carleton, James Chodosh, Ricardo Cibotti, Robert Davis, Joshua C Denny, Roni P Dodiuk-Gad, Elizabeth N Ergen, Jennifer L Goldman, James H Holmes, Shuen-Iu Hung, Mario E Lacouture, Rannakoe J Lehloenya, Simon Mallal, Teri A Manolio, Robert G Micheletti, Caroline M Mitchell, Maja Mockenhaupt, David A Ostrov, Rebecca Pavlos, Munir Pirmohamed, Elena Pope, Alec Redwood, Misha Rosenbach, Michael D Rosenblum, Jean-Claude Roujeau, Arturo P Saavedra, Hajirah N Saeed, Jeffery P Struewing, Hirohiko Sueki, Chonlaphat Sukasem, Cynthia Sung, Jason A Trubiano, Jessica Weintraub, Lisa M Wheatley, Kristina B Williams, Brandon Worley, Wen-Hung Chung, Neil H Shear, Elizabeth J Phillips
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a life-threatening, immunologically mediated, and usually drug-induced disease with a high burden to individuals, their families, and society with an annual incidence of 1 to 5 per 1,000,000. To effect significant reduction in short- and long-term morbidity and mortality, and advance clinical care and research, coordination of multiple medical, surgical, behavioral, and basic scientific disciplines is required. On March 2, 2017, an investigator-driven meeting was held immediately before the American Academy of Dermatology Annual meeting for the central purpose of assembling, for the first time in the United States, clinicians and scientists from multiple disciplines involved in SJS/TEN clinical care and basic science research...
January 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29301474/eruptive-melanocytic-nevi-in-a-patient-with-toxic-epidermal-necrolysis-like-cutaneous-lupus
#7
C Collantes-Rodríguez, D Jiménez-Gallo, C Arjona-Aguilera, L Ossorio-García, I Villegas-Romero, J M Báez-Perea, M Linares-Barrios
No abstract text is available yet for this article.
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29279184/-histopathology-of-cutaneous-drug-reactions
#8
Nicolas Ortonne
There are many different types of cutaneous adverse reactions. The most classical reactions are driven by T lymphocytes that specifically react towards a drug, with an individual genetic susceptibility linked to certain type I major histocompatibility complex alleles. These reactions are characterized by a wide variety of clinical and histopathological presentations, and a wide range of severity. The most frequent entity is the maculopapular rash, while the most aggressive forms are the Steven-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN)...
December 23, 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/29274302/association-of-cyp2c9-3-with-phenytoin-induced-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-a-systematic-review-and-meta-analysis
#9
X Wu, W Liu, W Zhou
WHAT IS KNOWN AND OBJECTIVE: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions that can be induced by phenytoin (PHT). CYP2C9*3 is the key enzyme in PHT metabolism. The aim of this meta-analysis was to evaluate the association between CYP2C9*3 and PHT-induced SJS/TEN. METHODS: An extensive search was performed in multiple databases, including the Cochrane Library, EMBASE, PubMed, OVID and EBSCO. Studies exploring the relationship between CYP2C9*3 and PHT-induced SJS and TEN were included...
December 23, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29273314/antibiotic-drug-use-and-the-risk-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-a-population-based-case-control-study
#10
Noel Frey, Andreas Bircher, Michael Bodmer, Susan S Jick, Christoph R Meier, Julia Spoendlin
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening mucocutaneous adverse drug reactions. Sulphonamide antibiotics are commonly accepted as one of the primary causes of SJS/TEN. This notion is based on results from two hospital-based case-control studies that identified the combined antibiotic cotrimoxazole (sulfamethoxazole and trimethoprim) as the cause of several SJS/TEN cases. Associations were also reported for penicillins, quinolones, cephalosporins, macrolides, tetracyclines, and metronidazole...
December 19, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29239905/specific-association-of-the-rs6500265-and-rs9933632-single-nucleotide-polymorphisms-in-japanese-patients-with-antipyretic-analgesic-related-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-with-severe-ocular-involvements
#11
Yoshimi Okamoto-Uchida, Ryosuke Nakamura, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito
A recent study using the microarray for single-nucleotide polymorphisms (SNPs) genotyping specifically designed for the Japanese population in combination with genome-wide imputation showed the association of several SNPs with cold medicine-related Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with severe ocular complications. However, it remains to be determined whether these polymorphisms are associated with the onset of antipyretic analgesic (AA)-related SJS/TEN, the progression of severe ocular involvements (SOIs), or both AA-related SJS/TEN and SOI phenotypes...
December 12, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/29238841/stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#12
Elizabeth Noble Ergen, Lauren C Hughey
No abstract text is available yet for this article.
December 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29228499/high-dose-intravenous-immunoglobulins-for-the-treatment-of-dermatological-autoimmune-diseases
#13
Jochen H O Hoffmann, Alexander H Enk
Based on their immunomodulatory properties, high-dose intravenous immunoglobulins (IVIGs) are successfully used in the treatment of various dermatological autoimmune diseases, in particular pemphigus vulgaris and dermatomyositis. In autoimmune bullous diseases, IVIGs can be used in an adjuvant setting (second- or third-line therapy) once combined immunosuppressive regimens have failed. In dermatomyositis, IVIGs may already be employed as an adjuvant second-line therapy after failure of corticosteroid monotherapy...
December 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29226159/immunohistopathological-findings-of-severe-cutaneous-adverse-drug-reactions
#14
REVIEW
Mari Orime
Diagnosis of severe cutaneous adverse drug reactions should involve immunohistopathological examination, which gives insight into the pathomechanisms of these disorders. The characteristic histological findings of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) provide conclusive evidence demonstrating that SJS/TEN can be distinguished from EM. Established SJS/TEN shows full-thickness, extensive keratinocyte necrosis that develops into subepidermal bullae. Drug-induced hypersensitivity syndrome (DIHS) and exanthema in drug reaction with eosinophilia and systemic symptoms (DRESS) each display a variety of histopathological findings, which may partly correlate with the clinical manifestations...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29225976/intensive-care-in-a-patient-with-toxic-epidermal-necrolysis
#15
J Wallenborn, M Fischer
Toxic epidermal necrolysis (TEN) is a serious adverse drug reaction with high lethality, which usually requires intensive-medical care. A 44-year-old man developed generalized exanthema with increasing exfoliation and mucosal involvement after taking allopurinol, ibuprofen, and etoricoxib. The clinical diagnosis of TEN was histologically confirmed. Prednisolone therapy with 3 mg/kg body weight (BW) was not able to prevent further progress to finally 80% of the body surface, and infliximab 5 mg/kg BW was given as a single dose...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29216902/improved-drug-safety-through-intensive-pharmacovigilance-in-hospitalized-pediatric-patients
#16
Alan O Vázquez-Alvarez, Lorena Michele Brennan-Bourdon, Ana Rosa Rincón-Sánchez, María Cristina Islas-Carbajal, Selene G Huerta-Olvera
BACKGROUND: The aim of this study was to detect and analyze Adverse Drug Reactions (ADRs) through Intensive Pharmacovigilance (IPV) in hospitalized pediatric patients to improve drug safety. METHODS: A prospective 6-month cross-sectional study was performed in the pediatric service of a regional hospital in Mexico in order to assess hospitalized children from 1 day to 18 years old. The inclusion criteria were: both genders, all hospitalization causes, and at least one prescribed medication (indistinct drug group)...
December 8, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29215146/case-of-thymoma-associated-cutaneous-graft-versus-host-disease-like-disease-successfully-improved-by-narrowband-ultraviolet-b-phototherapy
#17
Kazuki Yatsuzuka, Mikiko Tohyama, Fumiko Oda, Takashi Hashimoto, Koji Sayama
Thymoma-associated graft-versus-host disease (GVHD)-like disease is a rare paraneoplastic disease seen in patients with thymoma. Here, we describe the first case of thymoma-associated GVHD-like disease localized to the skin that was successfully improved by a combination of systemic corticosteroids and whole-body narrowband ultraviolet (UV)-B phototherapy. The patient had developed toxic epidermal necrolysis-like erosive skin lesions over the whole body. Although systemic corticosteroids were effective up to a point, we were unable to begin the steroid taper...
December 7, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29202605/toxic-epidermal-necrolysis-spectrum-management-at-sunnybrook-health-sciences-centre-our-multidisciplinary-approach-after-review-of-the-current-evidence
#18
Alexandra Mereniuk, Alejandra Jaque, Marc G Jeschke, Neil H Shear
Toxic epidermal necrolysis spectrum (TENS) is a rare yet severe adverse drug reaction associated with a high mortality rate. Beyond supportive care, there is still no established therapy for TENS, although recent meta-analyses and UK guideline recommendations have attempted to offer a review of relevant literature on this difficult topic. As most directed treatments lack clear consensual evidence, care centres often resort to establishing their own strategies. As Canada's largest adult burn centre and the provincial reference centre for most burn patients in Ontario, our team at the Ross Tilley Burn Centre, in collaboration with the Department of Dermatology at Sunnybrook Health Sciences Centre, Toronto, Canada, has managed over 60 confirmed cases of TENS over the past 2 decades...
December 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29188475/current-perspectives-on-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#19
REVIEW
Marianne Lerch, Carlo Mainetti, Benedetta Terziroli Beretta-Piccoli, Thomas Harr
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are considered a delayed-type hypersensitivity reaction to drugs. They represent true medical emergencies and an early recognition and appropriate management is decisive for the survival. SJS/TEN manifest with an "influenza-like" prodromal phase (malaise, fever), followed by painful cutaneous and mucous membrane (ocular, oral, and genital) lesions, and other systemic symptoms. The difference between SJS, SJS/TEN overlap, and TEN is defined by the degree of skin detachment: SJS is defined as skin involvement of < 10%, TEN is defined as skin involvement of > 30%, and SJS/TEN overlap as 10-30% skin involvement...
November 29, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29186246/severe-cutaneous-adverse-drug-reactions-of-chinese-inpatients-a-meta-analysis
#20
Qiancheng Deng, Xia Fang, Qinghai Zeng, Jianyun Lu, Chen Jing, Jinhua Huang
BACKGROUND: The rate of severe cutaneous adverse drug reactions is low, and these reactions can result in death or disability. An evidence-based epidemiological study of severe cutaneous adverse drug reactions in China has not been reported. OBJECTIVE: The aim of this study was to analyze epidemiology and characteristics of severe cutaneous adverse drug reactions of Chinese inpatients during the recent 15 years with meta-analysis. METHODS: We retrospectively reviewed Chinese literature reporting severe cutaneous adverse drug reactions and collecting data from 2000 to 2015, which were in accordance with our inclusion criteria...
May 2017: Anais Brasileiros de Dermatologia
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