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Toxic epidermal necrolysis

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https://www.readbyqxmd.com/read/28914974/mucocutaneous-inflammation-in-the-ikaros-family-zinc-finger-1-ikzf1-keratin-5-specifc-transgenic-mice
#1
Mayumi Ueta, Junji Hamuro, Hiromi Nishigaki, Naomi Nakamura, Katsuhiko Shinomiya, Katsura Mizushima, Yuki Hitomi, Risa Tamagawa-Mineoka, Norihiko Yokoi, Yuji Naito, Katsushi Tokunaga, Norito Katoh, Chie Sotozono, Shigeru Kinoshita
BACKGROUND: Our genome-wide association study documented an association between cold medicine related Stevens-Johnson syndrome / toxic epidermal necrolysis (CM-SJS/TEN) and Ikaros Family Zinc Finger 1 (IKZF1). Few studies examined biological and pathological functions of IKZF1 in mucosal immunity. We hypothesized that IKZF1 contributes to the mucocutaneous inflammation. METHODS: Human skin and conjunctival tissues were obtained for immunohistological studies. Primary human conjunctival epithelial cells (PHCjECs) and adult human epidermal keratinocytes (HEKa) also used for gene expression analysis...
September 15, 2017: Allergy
https://www.readbyqxmd.com/read/28891542/drug-induced-stevens-johnson-syndrome-in-indian-population-a-multicentric-retrospective-analysis
#2
H N Hirapara, T K Patel, M J Barvaliya, C Tripathi
BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening hypersensitivity reactions mainly caused by drugs. Data on incubation period, hospital stay, and outcome for HIV-positive patients are sparse. Role of corticosteroids in their management is still controversial. METHODS: Indoor cases of SJS, SJS-TEN overlap, and TEN were analyzed for causative drugs, incubation period, a severity-of-illness score for toxic epidermal necrolysis (SCORTEN) score, HIV status, treatment, and outcome...
August 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28885988/dapsone-induced-severe-cutaneous-adverse-drug-reactions-are-strongly-linked-with-hla-b-13-01-allele-in-the-thai-population
#3
Therdpong Tempark, Patompong Satapornpong, Pawinee Rerknimitr, Nontaya Nakkam, Niwat Saksit, Penpun Wattanakrai, Thawinee Jantararoungtong, Napatrupron Koomdee, Ajanee Mahakkanukrauh, Wichittra Tassaneeyakul, Sumitra Suttisai, Jirawat Pratoomwun, Jettanong Klaewsongkram, Ticha Rerkpattanapipat, Chonlaphat Sukasem
OBJECTIVES: A previous publication in Chinese leprosy patients showed that the HLA-B*13:01 allele is a strong genetic marker for dapsone-induced drug hypersensitivity reactions, however there are no data describing whether HLA-B*13:01 is a valid marker for prediction of dapsone-induced drug hypersensitivity reactions in other ethnicities or nonleprosy patients. The aim of this study is to investigate whether there is an association between HLA genotypes and dapsone-induced severe cutaneous adverse reactions (SCARs) in nonleprosy patients...
September 6, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28884910/successful-use-of-cyclosporin-a-for-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-three-children
#4
Jessica St John, Vladimir Ratushny, Kristina J Liu, Daniel Q Bach, Omar Badri, Lia E Gracey, Allen W Ho, Adam B Raff, Daniel Y Sugai, Peter Schalock, Daniela Kroshinsky
BACKGROUND/OBJECTIVES: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are medical emergencies. Mainstays of treatment include removal of the offending agent, supportive care, and wound care. The use of immunosuppressive agents such as corticosteroids and intravenous immunoglobulin (IVIg) is controversial. Some case reports and small studies report the successful use of cyclosporin A (CsA) for SJS/TEN in halting disease progression, fostering reepithelialization, and reducing mortality...
September 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28867742/effect-of-infectious-diseases-on-the-pathogenesis-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#5
Yoshimi Okamoto-Uchida, Ryosuke Nakamura, Kimie Sai, Takuya Imatoh, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions. Recent studies have revealed that the prevalence of SJS/TEN is associated with genetic backgrounds, such as polymorphisms in human leukocyte antigens (HLAs). However, non-genetic factors contributing to the etiology of SJS/TEN are largely unknown. This study aimed to assess the involvement of concurrent infection on the pathological states of SJS/TEN, examining the severity of cutaneous symptoms and ocular involvement as well as the time to onset in drug-induced SJS/TEN patients...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28857441/diagnostic-utility-of-hla-b-5801-screening-in-severe-allopurinol-hypersensitivity-syndrome-an-updated-systematic-review-and-meta-analysis
#6
Kuang-Hui Yu, Cheng-Yen Yu, Yao-Fan Fang
BACKGROUND: Despite many studies suggesting an association between human leukocyte antigen (HLA)-B*5801 and allopurinol-induced toxic epidermal necrolysis (TEN) and Stevens-Johnsons syndrome (SJS), the evidence of association in different populations and the degree of association remain uncertain. METHODS: The primary analysis was based on population-control studies. Data were pooled by means of a random-effects model, and sensitivity, specificity, positive likelihood ratios (LR+), negative likelihood ratios (LR-), diagnostic odds ratios (DOR), and areas under summary receiver operating characteristic (SROC) curves (AUC) were calculated...
August 31, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28831528/association-between-infection-and-severe-drug-adverse-reactions-an-analysis-using-data-from-the-japanese-adverse-drug-event-report-database
#7
Takuya Imatoh, Kimie Sai, Chisato Fukazawa, Yasushi Hinomura, Ryosuke Nakamura, Yoshimi Okamoto-Uchida, Katsunori Segawa, Yoshiro Saito
PURPOSE: It has been reported recently that immune reactions are involved in the pathogenesis of certain types of adverse drug reactions (ADRs). We aimed to determine the associations between infections and drug-induced interstitial lung disease (DILD), rhabdomyolysis, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), or drug-induced liver injury (DILI) using a spontaneous adverse drug event reporting database in Japan. METHODS: The reported cases were classified into three categories (anti-infectious drug group, concomitant infection group, and non-infection group) based on the presence of anti-infectious drugs (either as primary suspected drug or concomitant drug) and infectious disease...
August 22, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28830900/mycoplasma-pneumoniae-induced-rash-and-mucositis-a-recently-described-entity
#8
Rui Pedro Santos, Marta Silva, Ana Paula Vieira, Celeste Brito
Mycoplasmapneumoniae is a common cause of respiratory infections. Although most cases are mild, some patients have extrapulmonary complications including mucocutaneous eruptions including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and erythemamultiforme (EM). Recently, a new entity, called M. pneumoniae-induced rash and mucositis (MIRM) was described. The authors present a clinical case difficult to classify attending to the classical classification of epidermolytic syndromes that meets the criteria proposed for the diagnosis of MIRM...
August 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28776776/toxic-epidermal-necrolysis-treatment-without-immunosuppressive-therapy-in-a-burn-centre-a-series-of-10-cases
#9
LETTER
P Gacto-Sanchez, J J Pereyra-Rodriguez, J Carbajal, T Gomez-Cía, J Conejo-Mir
No abstract text is available yet for this article.
August 4, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28769568/incidence-causative-drugs-and-economic-consequences-of-drug-induced-sjs-ten-and-sjs-ten-overlap-and-potential-drug-drug-interactions-during-treatment-a-retrospective-analysis-at-an-indonesian-referral-hospital
#10
Rizky Abdulah, Tazkia F Suwandiman, Nadhira Handayani, Dika P Destiani, Auliya A Suwantika, Melisa I Barliana, Keri Lestari
BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute life-threatening adverse drug reactions (ADRs) that are commonly caused by medications. Apart from their contribution to morbidity and mortality, these diseases may also present substantial consequences on health care resources. In this study, we aimed to identify the incidence, causative drugs, and economic consequences of these serious ADRs and potential drug-drug interactions (DDIs) during treatment...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28758256/hospitalization-and-outcomes-attributed-to-epidermal-necrolysis-in-united-states-predictors-of-mortality
#11
Veerajalandhar Allareddy, Sankeerth Rampa, Veerasathpurush Allareddy
Acute life-threatening mucocutaneous reactions characterized by extensive necrosis and detachment of the epidermis(epidermal necrolysis,EN) includes the spectrum of Stevens-Johnson syndrome (SJS, <10% body surface area), Toxic epidermal necrolysis (TEN, >20% BSA) and the SJS-TEN overlap(10-20%BSA). Prior older studies have revealed that the incidence of these rare conditions was estimated to be 1 to 6 cases per million person-years for SJS and 0.4 to 1.2 cases per million person-years for TEN. Current, large population based hospitalization outcomes attributed to EN in United States are lacking...
July 31, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28751000/linear-iga-bullous-dermatosis-presenting-as-toxic-epidermal-necrolysis
#12
J Ruiz-Rivero, I Hernández-Aragüés, A Pulido-Pérez, R Suárez-Fernández
No abstract text is available yet for this article.
July 24, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28744306/prevalence-and-clinical-profile-of-drug-eruptions-among-antiretroviral-therapy-exposed-hiv-infected-people-in-yaound%C3%A3-cameroon
#13
Emmanuel Armand Kouotou, Jobert Richie Nansseu, Vanessa Nancy Ngono, Sandra A Tatah, Anne Cecile Zoung-Kanyi Bissek, Elie Claude Ndjitoyap Ndam
BACKGROUND: Prevalence and incidence of drug eruptions vary around the world and are influenced by some key factors including HIV infection. OBJECTIVE: This study aimed to find the peculiarities of drug eruptions in people living with HIV (PLHIV) and on antiretroviral therapy (ART). METHODS: This was a retrospective cross-sectional study including ART-taking PLHIV, aged 15+ years, followed up between January 2010 and December 2014 at the day-care unit of the Yaoundé Central Hospital, and who presented with drug eruptions after ART initiation...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/28733562/incidence-of-cutaneous-adverse-drug-reactions-among-medical-inpatients-of-sultanah-aminah-hospital-johor-bahru
#14
S Latha, S E Choon
INTRODUCTION: Cutaneous adverse drug reactions (cADRs) are common. There are only few studies on the incidence of cADRs in Malaysia. OBJECTIVE: To determine the incidence, clinical features and risk factors of cADRs among hospitalized patients. METHODS: A prospective study was conducted among medical inpatients from July to December 2014. RESULTS: A total of 43 cADRs were seen among 11 017 inpatients, yielding an incidence rate of 0...
June 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28724844/a-review-of-the-active-treatments-for-toxic-epidermal-necrolysis
#15
Yuri Kinoshita, Hidehisa Saeki
Toxic epidermal necrolysis (TEN) is a severe adverse drug reaction associated with the separation of skin and mucous membranes at the dermal-epidermal junction. Although it is rare, many treatments have been trialed because of its high mortality rate. Active interventions performed to date include the use of systemic corticosteroids, intravenous immunoglobulins (IVIg), cyclosporine, plasmapheresis, anti-tumor necrosis factor drugs and N-acetylcysteine, but none has been established as the most effective therapy...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28721106/adverse-reactions-in-leprosy-patients-who-underwent-dapsone-multidrug-therapy-a-retrospective-study
#16
Sanjeev Guragain, Namrata Upadhayay, Bishwa Mohan Bhattarai
OBJECTIVE: To investigate the occurrence and clinical characteristics of dapsone-related adverse drug reactions (ADRs) among leprosy patients who underwent multidrug therapy (MDT) from 2010 to 2013 in the western region of Nepal. METHODS: A retrospective review was carried out in the rehabilitation center. Data were collected from the record files of the hospital. RESULTS: From 2010 to 2013, there were 18 patients reported to have dapsone ADRs, with an occurrence rate of 0...
2017: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/28710842/severe-sequelae-of-erythema-multiforme-three-cases
#17
A Viarnaud, S Ingen-Housz-Oro, M Marque, L Valeyrie-Allanore, N Ortonne, J Gueudry, S Grootenboer-Mignot, M Muraine, E Bequignon, C Gagnière, F Schlemmer, P Wolkenstein, O Chosidow
Erythema multiforme (EM) is a skin condition for which main causes are infectious factors (Herpes simplex virus, Mycoplasma pneumoniae). Anti-plakin auto-antibodies are found in some patients (1) . EM must be distinguished from Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which are drug-induced in most cases (2-5) . This article is protected by copyright. All rights reserved.
July 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28709416/warfarin-induced-toxic-epidermal-necrolysis-in-combination-therapy-of-henoch-sch%C3%A3-nlein-purpura-nephritis-a-case-report
#18
Katsuaki Kasahara, Yoshimitsu Gotoh, Yoshiyuki Kuroyanagi, China Nagano
BACKGROUND: Toxic epidermal necrolysis (TEN) is a rare life-threatening condition almost exclusively attributed to drugs. The main etiologic factors for TEN are sulphonamides, anticonvulsants, and antibiotics; however, there are no published reports of warfarin causing TEN. CASE PRESENTATION: We present the case of a 3-year-old patient who developed TEN while receiving treatment for Henoch-Schönlein purpura nephritis (HSPN). With multiple-drug therapy comprising prednisolone, mizoribine, dipyridamole, and warfarin, it is difficult to detect which drug is the causative agent...
July 14, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28689274/impact-of-glutathione-transferases-genes-polymorphisms-in-nevirapine-adverse-reactions-a-possible-role-for-gstm1-in-sjs-ten-susceptibility
#19
Cinzia Ciccacci, Andrea Latini, Cristina Politi, Sandro Mancinelli, Maria C Marazzi, Giuseppe Novelli, Leonardo Palombi, Paola Borgiani
PURPOSE: Nevirapine (NVP) is used in developing countries as first-line treatment of HIV infection. Unfortunately, its use is associated with common serious adverse drug reactions, such as liver toxicity and the most severe and rare Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). GSTT1 and GSTM1 genes code for enzymes involved in the metabolism of a wide range of drugs. We hypothesized that this gene variability could be implicated in NVP adverse reactions. METHODS: We analyzed the GSTM1 and GSTT1 null genotypes by multiplex PCR in a population of 181 patients from Mozambique, treated with NVP...
July 8, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28688239/successful-treatment-of-toxic-epidermal-necrolysis-using-plasmapheresis-a-prospective-observational-study
#20
Feng Han, Jingjing Zhang, Qi Guo, Yanjing Feng, Ya Gao, Litao Guo, Yanli Hou, Jingang An, Xiaopeng Wang, Bin Yan, Yan Zheng, Jingchun Song, Manxiang Li, Gang Wang
Toxic epidermal necrolysis (TEN) is a rare, severe, life-threatening skin disease and it requires urgent critical care, including admission to the intensive care unit (ICU). It is characterized by fatal sequelae and high mortality. Currently, insufficient evidence exists to support the use of any systemic adjuvant therapy, such as cyclophosphamide, intravenous immunoglobulin (IVIg), or corticosteroids. However, plasmapheresis has been increasingly valued by clinicians due to its significant efficacy and little adverse side effects...
July 1, 2017: Journal of Critical Care
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