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https://www.readbyqxmd.com/read/29226556/solvent-or-thermal-extraction-of-ethylene-oxide-from-polymeric-materials-medical-device-considerations
#1
Anne D Lucas, Christopher Forrey, David M Saylor, Katherine Vorvolakos
Ethylene oxide (EO) gas is commonly used to sterilize medical devices. Bioavailable residual EO, however, presents a significant toxicity risk to patients. Residual EO is assessed using international standards describing extraction conditions for different medical device applications. We examine a series of polymers and explore different extraction conditions to determine residual EO. Materials were sterilized with EO and exhaustively extracted in water, in one of three organic solvents, or in air using thermal desorption...
December 11, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29191323/transcatheter-aortic-valve-replacement-in%C3%A2-pure-native-aortic-valve-regurgitation
#2
MULTICENTER STUDY
Sung-Han Yoon, Tobias Schmidt, Sabine Bleiziffer, Niklas Schofer, Claudia Fiorina, Antonio J Munoz-Garcia, Ermela Yzeiraj, Ignacio J Amat-Santos, Didier Tchetche, Christian Jung, Buntaro Fujita, Antonio Mangieri, Marcus-Andre Deutsch, Timm Ubben, Florian Deuschl, Shingo Kuwata, Chiara De Biase, Timothy Williams, Abhijeet Dhoble, Won-Keun Kim, Enrico Ferrari, Marco Barbanti, E Mara Vollema, Antonio Miceli, Cristina Giannini, Guiherme F Attizzani, William K F Kong, Enrique Gutierrez-Ibanes, Victor Alfonso Jimenez Diaz, Harindra C Wijeysundera, Hidehiro Kaneko, Tarun Chakravarty, Moody Makar, Horst Sievert, Christian Hengstenberg, Bernard D Prendergast, Flavien Vincent, Mohamed Abdel-Wahab, Luis Nombela-Franco, Miriam Silaschi, Giuseppe Tarantini, Christian Butter, Stephan M Ensminger, David Hildick-Smith, Anna Sonia Petronio, Wei-Hsian Yin, Federico De Marco, Luca Testa, Nicolas M Van Mieghem, Brian K Whisenant, Karl-Heinz Kuck, Antonio Colombo, Saibal Kar, Cesar Moris, Victoria Delgado, Francesco Maisano, Fabian Nietlispach, Michael J Mack, Joachim Schofer, Ulrich Schaefer, Jeroen J Bax, Christian Frerker, Azeem Latib, Raj R Makkar
BACKGROUND: Limited data exist about safety and efficacy of transcatheter aortic valve replacement (TAVR) in patients with pure native aortic regurgitation (AR). OBJECTIVES: This study sought to compare the outcomes of TAVR with early- and new-generation devices in symptomatic patients with pure native AR. METHODS: From the pure native AR TAVR multicenter registry, procedural and clinical outcomes were assessed according to VARC-2 criteria and compared between early- and new-generation devices...
December 5, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29184426/recommendations-for-volume-augmentation-and-rejuvenation-of-the-face-and-hands-with-the-new-generation-polycaprolactone-based-collagen-stimulator-ellans%C3%A3-%C3%A2
#3
REVIEW
Francisco de Melo, Pierre Nicolau, Luca Piovano, Shang-Li Lin, Tiago Baptista-Fernandes, Martyn I King, Alessandra Camporese, Kyungkook Hong, Maria M Khattar, Marie-Odile Christen
Background: The range of fillers currently available for soft-tissue augmentation is constantly expanding. The latest advances in filler technology include collagen biostimulators that exert their esthetic effect by promoting neocollagenesis. One such product is the next-generation collagen biostimulator (Ellansé®) that demonstrates properties as yet unseen in soft-tissue fillers. It is composed of polycaprolactone (PCL) microspheres in an aqueous carboxymethylcellulose gel carrier...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29180742/out-of-plane-heat-transfer-in-van-der-waals-stacks-through-electron-hyperbolic-phonon-coupling
#4
Klaas-Jan Tielrooij, Niels C H Hesp, Alessandro Principi, Mark B Lundeberg, Eva A A Pogna, Luca Banszerus, Zoltán Mics, Mathieu Massicotte, Peter Schmidt, Diana Davydovskaya, David G Purdie, Ilya Goykhman, Giancarlo Soavi, Antonio Lombardo, Kenji Watanabe, Takashi Taniguchi, Mischa Bonn, Dmitry Turchinovich, Christoph Stampfer, Andrea C Ferrari, Giulio Cerullo, Marco Polini, Frank H L Koppens
Van der Waals heterostructures have emerged as promising building blocks that offer access to new physics, novel device functionalities and superior electrical and optoelectronic properties 1-7 . Applications such as thermal management, photodetection, light emission, data communication, high-speed electronics and light harvesting 8-16 require a thorough understanding of (nanoscale) heat flow. Here, using time-resolved photocurrent measurements, we identify an efficient out-of-plane energy transfer channel, where charge carriers in graphene couple to hyperbolic phonon polaritons 17-19 in the encapsulating layered material...
November 27, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/29178798/dissolution-of-monocrystalline-silicon-nanomembranes-and-their-use-as-encapsulation-layers-and-electrical-interfaces-in-water-soluble-electronics
#5
Yoon Kyeung Lee, Ki Jun Yu, Enming Song, Amir Barati Farimani, Flavia Vitale, Zhaoqian Xie, Younghee Yoon, Yerim Kim, Andrew Richardson, Haiwen Luan, Yixin Wu, Xu Xie, Timothy H Lucas, Kaitlyn Crawford, Yongfeng Mei, Xue Feng, Yonggang Huang, Brian Litt, Narayana R Aluru, Lan Yin, John A Rogers
The chemistry that governs the dissolution of device-grade, monocrystalline silicon nanomembranes into benign end products by hydrolysis serves as the foundation for fully eco/biodegradable classes of high performance electronics. This paper examines these processes in aqueous solutions with chemical compositions relevant to ground water and biofluids. The results show that the presence of Si(OH)4 and proteins in these solutions can slow the rates of dissolution and that ion specific effects associated with Ca2+ can significantly increase these rates...
November 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/29178780/extra-ordinary-effects-in-quasi-periodic-gold-nano-cavities-enhanced-transmission-and-polarization-control-of-cavity-modes
#6
Rakesh Dhama, Vincenzo Caligiuri, Lucia Petti, Alireza Rahimi Rashed, Massimo Rippa, Raffaella Lento, Roberto Termine, Humeyra Caglayan, Antonio De Luca
Plasmonic quasi periodic structures are well known to exhibit several surprising phenomena with respect to their periodic counterparts, due to their long range order and higher rotational symmetry. Thanks to their specific geometrical arrangement, plasmonic quasi-crystals offer unique possibilities in tailoring the coupling and propagation of surface plasmons through their lattice, a scenario in which a plethora of novel phenomena can take place. In this paper we investigate the Extra-Ordinary Transmission (EOT) phenomenon occurring in specifically patterned Thue-Morse nano-cavities, demonstrating noticeable enhanced transmission, directly revealed by near field optical experiments, performed by means of a Scanning Near-field Optical Microscope (SNOM)...
November 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/29178262/selective-detection-of-%C3%AE-4%C3%AE-1-integrin-vla-4-expressing-cells-using-peptide-functionalized-nanostructured-materials-mimicking-endothelial-surfaces-adjacent-to-inflammatory-sites
#7
Rossella De Marco, Arianna Greco, Natalia Calonghi, Samantha D Dattoli, Monica Baiula, Santi Spampinato, Pierre Picchetti, Luisa De Cola, Michele Anselmi, Francesca Cipriani, Luca Gentilucci
Persistent accumulation of immune cells mediated by α4β1 integrin (VLA-4) is a hallmark of the inflammatory diseases and of chronic inflammation observed in the affected tissues of autoimmune diseases. Aiming at exploring new methods for monitoring the course of the inflammatory processes, we designed the first peptide-functionalized nanostructured devices capable to mimic the high-density multivalency binding between the α4β1 integrin-expressing cells and the ligands overexpressed on the endothelial surfaces, in the proximity of the sites of inflammation...
November 27, 2017: Biopolymers
https://www.readbyqxmd.com/read/29173476/free-copper-in-serum-an-analytical-challenge-and-its-possible-applications
#8
Simona Catalani, Matteo Paganelli, Maria Enrica Gilberti, Luca Rozzini, Francesco Lanfranchi, Alessandro Padovani, Pietro Apostoli
Copper (Cu), as an essential metal, plays a crucial role in biochemical reactions and in physiological regulations. Cu in plasma is mostly bound to proteins; about 65-90% of Cu is tightly binds with caeruloplasmin and the rest of Cu is loosely binds with albumin and transcuprein. A small but significant relatively "free" fraction, probably complexed with amino acids, is present at around 5% of the total concentration. We developed and validated a new method for direct measurement of free Cu in serum by ultrafiltration with AMICON®Ultra 100K device and determination with AAS...
January 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29160331/primum-non-nocere-or-primum-facere-meliorem-hacking-the-brain-in-the-21st-century
#9
Lucas Borrione, Andre R Brunoni
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that modulates cortical excitability. It is devoid of serious adverse events and exerts variable effects on cognition, with several research findings suggesting that it can improve memory, verbal and mathematical skills. Because tDCS devices are low-cost, portable and relatively easy to assemble, they have become available outside of the medical setting and used for non-medical ("cosmetic") purposes by laypersons. In this sense, tDCS has become a popular technique aiming to improve cognition and the achievement of a better performance not only at work, but also in other fields such as sports, leisure activities (video games) and even the military...
November 13, 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/29147083/spinal-cord-stimulation-in-failed-back-surgery-syndrome-effects-on-posture-and-gait-a-preliminary-3d-biomechanical-study
#10
L Brugliera, A De Luca, S Corna, M Bertolotto, G A Checchia, M Cioni, P Capodaglio, C Lentino
We studied 8 patients with spinal cord stimulation (SCS) devices which had been previously implanted to treat neuropathic chronic pain secondary to Failed Back Surgery Syndrome. The aim of our study was to investigate the effects of SCS on posture and gait by means of clinical scales (Short Form Health Survey-36, Visual Analogue Scale for pain, and Hamilton Depression Rating Scale) and instrumented evaluation with 3D Gait Analysis using a stereophotogrammetric system. The latter was performed with the SCS device turned both OFF and ON...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29108514/hypothermic-oxygenated-machine-perfusion-for-liver-transplantation-an-initial-experience
#11
Damiano Patrono, Bruna Lavezzo, Luca Molinaro, Giorgia Rizza, Giorgia Catalano, Federica Gonella, Mauro Salizzoni, Renato Romagnoli
OBJECTIVES: Due to widespread exploitation of extended criteria donors, machine perfusion is emerging as an alternative to static cold storage for organ preservation. Hypothermic oxygenated machine perfusion has been associated with improved outcomes after liver transplant, both in laboratory and clinical settings. Here, we present our initial experience with hypothermic oxygenated machine perfusion, evaluating incidence of postreperfusion syndrome, early allograft dysfunction, and long-term biliary complications...
October 31, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29107162/artificial-stroke-clots-how-wide-is-the-gap-to-the-real-world
#12
Maria Berndt, Sascha Prothmann, Christian Maegerlein, Paul Oberdieck, Claus Zimmer, Barbara Hegge, Jaroslav Pelisek, Lucas Schirmer, Holger Poppert, Tobias Boeckh-Behrens
OBJECTIVE: Especially since the establishment of mechanical thrombectomy as part of the standard stroke therapy, artificial thrombi have become important in the training of interventionalists as well as for the development and testing of devices. So far, these in vitro clots lack direct comparisons with ex vivo thrombi. We therefore compared the histological appearance of dynamically produced clots with that of stroke thrombi acquired during mechanical recanalization. METHODS: Thrombi of 145 consecutive stroke patients with large-vessel occlusions were histologically compared with 10 artificial clots, dynamically created from human blood and pig's blood using a Chandler loop system...
October 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29106523/combining-watchman-left-atrial-appendage-closure-and-catheter-ablation-for-atrial-fibrillation-multicentre-registry-results-of-feasibility-and-safety-during-implant-and-30-days-follow-up
#13
Karen P Phillips, Evgeny Pokushalov, Aleksandr Romanov, Sergey Artemenko, Richard J Folkeringa, Tamas Szili-Torok, Gaetano Senatore, Kenneth M Stein, Omar Razali, Nicole Gordon, Lucas V A Boersma
Aims: Long-term results from catheter ablation therapy for atrial fibrillation (AF) remain uncertain and clinical practice guidelines recommend continuation of long-term oral anticoagulation in patients with a high stroke risk. Left atrial appendage closure (LAAC) with Watchman has emerged as an alternative to long-term anticoagulation for patients accepting of the procedural risks. We report on the initial results of combining catheter ablation procedures for AF and LAAC in a multicentre registry...
July 3, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29105687/-early-and-mid-term-results-of-the-transapical-aortic-valve-symetis-acurate-ta-a-viable-solution-in-high-risk-patients-with-severe-vascular-disease
#14
Giuseppe Rescigno, Maria Giovanna Fratesi, Carlo Aratari, Stefano Moretti, Filippo Capestro, Massimiliano Serenelli, Luca Piangerelli, Anca Delca, Gian Piero Perna, Alessandro Capucci, Marco Di Eusanio
BACKGROUND: Aortic valve stenosis is the most common valvular disease in the elderly. Transcatheter aortic valve implantation represents a viable alternative to conventional aortic valve replacement. In our Department, the transapical approach is the preferred method in patients with severe peripheral vascular disease. The aim of this study was to analyze the early and midterm results of Symetis Acurate TA implantation in our series. METHODS: From June 2013 to January 2017, 21 patients with severe peripheral vascular disease (11 male, mean age 78 ± 2...
October 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29105685/-cardiogenic-shock-from-pharmacological-treatment-to-mechanical-circulatory-support
#15
Ilaria Battistoni, Marco Marini, Alberto Lavorgna, Fabio Vagnarelli, Fabiana Lucà, Emilia Biscottini, Giorgio Caretta, Vincenza Procaccini, Letizia Riva, Gabriele Vianello, Massimo Iacoviello, Renata De Maria, Alessandro Navazio, Nadia Aspromonte, Andrea Di Lenarda, Michele Massimo Gulizia, Serafina Valente
Cardiogenic shock (CS) is a state of critical end-organ hypoperfusion due to reduced cardiac output, despite adequate filling status. The development of multiorgan dysfunction is believed to be the major contributor to the high early mortality. Little evidence exists as to which vasopressor or inotrope should best be used for early treatment; however, customized pharmacological therapy, tailored on hemodynamic monitoring, is essential to achieve normal peripheral perfusion. Moreover, an increasing number of mechanical circulatory support devices are available for hemodynamic support in patients with CS but, at present, data derived from randomized clinical trials on the effectiveness, safety, differential indications for mechanical support devices, and optimal implant timing are limited...
October 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29100806/comparison-of-sacrificed-healthy-aorta-during-thoracoabdominal-aortic-aneurysm-repair-using-off-the-shelf-endovascular-branched-devices-and-open-surgery
#16
Luca Bertoglio, Tommaso Cambiaghi, Ciro Ferrer, Domenico Baccellieri, Fabio Verzini, Germano Melissano, Roberto Chiesa, Yamume Tshomba
BACKGROUND: Off-the-shelf devices for branched endovascular aortic repair of thoracoabdominal aortic aneurysm (TAAA) have been developed to overcome the manufacturing- and logistics-related delays characteristic of device customization. Nonetheless, the structural requirements of branched endovascular aortic repair, together with the need for additional thoracic components to suit different anatomies, might lead to a large sacrifice of healthy aorta. METHODS: We enrolled 18 consecutive TAAA patients treated between 2010 and 2016 in two centers employing the off-the-shelf t-Branch (Cook Medical, Bloomington, Ind) device (TB group)...
October 31, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29099572/all-in-one-graphene-based-composite-fiber-toward-wearable-supercapacitor
#17
Lucas Lim, Yangshuai Liu, Wenwen Liu, Ricky Tjandra, Lathankan Rasenthiram, Zhongwei Chen, Aiping Yu
Graphene fibers (GF) have aroused great interest in wearable electronics applications because of their excellent mechanical flexibility and superior electrical conductivity. Herein, an all-in-one graphene and MnO2 composite hybrid supercapacitor fiber device has been developed. The unique coaxial design of this device facilitates large-scale production while avoiding the risk of short circuiting. The core backbone of the device consists of GF that not only provides mechanical stability but also ensures fast electron transfer during charge-discharge...
November 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29095059/tendon-transfer-surgery-focus-on%C3%A2
#18
Roberto Cuomo, Luca Grimaldi, Giuseppe Nisi, Cesare Brandi, Carlo D'Aniello
Median and Ulnar nerve palsy is a devastating condition that compromise hand function. A procedure of tendon transfer may be helpful to restore the movements by linking palsy muscles to other muscles able to contract. Scientific discoveries and technological innovations have profoundly changed this kind of surgery; studies on sarcomeres, for example, changed the concept of tensioning. To date we know that muscle strength and its contraction capacity depends on many factors (not only tensioning) such as sarcomeres length, cellular cytoskeleton and extracellular matrix composition: all of these factors interact together and in a ways not still fully understood, determining the complex concept of "movement...
November 2, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29092522/design-and-operating-characteristic-of-a-vacuum-furnace-for-time-of-flight-inelastic-neutron-scattering-measurements
#19
J L Niedziela, R Mills, M J Loguillo, H D Skorpenske, D Armitage, H L Smith, J Y Y Lin, M S Lucas, M B Stone, D L Abernathy
We present the design and operating characteristics of a vacuum furnace used for inelastic neutron scattering experiments on a time-of-flight chopper spectrometer. The device is an actively water cooled radiant heating furnace capable of performing experiments up to 1873 K. Inelastic neutron scattering studies performed with this furnace include studies of phonon dynamics and metallic liquids. We describe the design, control, characterization, and limitations of the equipment. Further, we provide comparisons of the neutron performance of our device with commercially available options...
October 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29084016/validation-of-a-new-piezoelectric-device-for-noninvasive-measurement-of-central-aortic-systolic-blood-pressure
#20
Paula E Cuffaro, Margarita S Morales, Jessica Barochiner, Marcelo A Rada, José Alfie, Lucas S Aparicio, Carlos R Galarza, Rubén G Micali, Marcos J Marin, Gabriel D Waisman
OBJECTIVE: The objective of this study was to compare the aortic piezoelectric device for noninvasive measurement of central aortic systolic blood pressure (cSBP) with the SphygmoCor. PARTICIPANTS AND METHODS: A total of 85 participants from both sexes, aged 18-80 years, were stratified into three age groups (<30, 30-60, >60 years), with an equal number of healthy volunteers and hypertensive patients. We performed three cSBP measurements with each device, in an alternate manner, using the Bland-Altman method to determine the level of agreement...
October 27, 2017: Blood Pressure Monitoring
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