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Lucas Device

Florence Benn, Natalie E C Haley, Alexandra E Lucas, Emma Silvester, Seham Helmi, Robert Schreiber, Jonathan Bath, Andrew J Turberfield
We report the design and assembly of chiral DNA nanotubes with well-defined and addressable inside and outside surfaces. We demonstrate that the outside surface can be functionalised with a chiral arrangement of gold nanoparticles to create a plasmonic device and that the inside surface can be functionalised with a track for a molecular motor allowing transport of a cargo within the central cavity.
April 18, 2018: Angewandte Chemie
Arianna Ferrari, Luca Bertolaccini, Piergiorgio Solli, Paola Oriana Di Salvia, David Scaradozzi
Lung cancer is the leading cause of cancer death and second most common cancer among both men and women, but most of them are detected when patients become symptomatic and in late-stage. Chest radiography (CR) is a basic technique for the investigation of lung cancer and has the benefit of convenience and low radiation dose, but detection of malignancy is often difficult. The introduction of computed tomography (CT) for screening has increased the proportion of lung cancer detected but with higher exposure dose and higher costs...
March 2018: Annals of Translational Medicine
Gil Joon Suh, Jaeheung Park, Jung Chan Lee, Sang Hoon Na, Woon Yong Kwon, Kyung Su Kim, Taegyun Kim, Yoon Sun Jung, Jung-In Ko, So Mi Shin, Kyoung Min You
BACKGROUND: Our aim was to compare the efficacy of the end-tidal CO2 -guided automated robot CPR (robot CPR) system with manual CPR and mechanical device CPR. METHODS: We developed the algorithm of the robot CPR system which automatically finds the optimal compression position under the guidance of end-tidal CO2 feedback in swine models of cardiac arrest. Then, 18 pigs after 11 minutes of cardiac arrest were randomly assigned to one of three groups, robot CPR, LUCAS CPR, and manual CPR groups (n = 6 each group)...
April 14, 2018: Resuscitation
Giuseppe Stabile, Patrizia Pepi, Pietro Palmisano, Antonio D'Onofrio, Antonio De Simone, Salvatore Ivan Caico, Domenico Pecora, Antonio Rapacciuolo, Giuseppe Arena, Massimiliano Marini, Paolo Pieragnoli, Sandra Badolati, Gianluca Savarese, Gianpiero Maglia, Assunta Iuliano, Giovanni Luca Botto, Maurizio Malacrida, Emanuele Bertaglia
BACKGROUND: Professional guidelines are based on the best available evidence. However, patients treated in clinical practice may differ from those included in reference trials. OBJECTIVE: The aim of this study was to evaluate the effects of cardiac resynchronization therapy (CRT) in a large population of patients implanted with a CRT device, stratified in accordance with the 2016 European heart failure (HF) guidelines. METHODS: We collected data on 930 consecutive patients from the CRT-MORE registry...
April 14, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Sergii Golovynskyi, Oleksandr I Datsenko, Luca Seravalli, Giovanna Trevisi, Paola Frigeri, Ivan S Babichuk, Iuliia Golovynska, Junle Qu
Photoelectric properties of the metamorphic InAs/In x Ga1 - x As quantum dot (QD) nanostructures were studied at room temperature, employing photoconductivity (PC) and photoluminescence spectroscopies, electrical measurements, and theoretical modeling. Four samples with different stoichiometry of In x Ga1 - x As cladding layer have been grown: indium content x was 0.15, 0.24, 0.28, and 0.31. InAs/In0.15 Ga0.85 As QD structure was found to be photosensitive in the telecom range at 1.3 μm. As x increases, a redshift was observed for all the samples, the structure with x = 0...
April 16, 2018: Nanoscale Research Letters
Luca Koechlin, Joachim M Erb, Christoph Kohler, Thibault Schaeffer, Friedrich S Eckstein, Martin T R Grapow
No abstract text is available yet for this article.
April 2018: Circulation. Cardiovascular Imaging
Luca D'Amario, Jens Föhlinger, Gerrit Boschloo, Leif Hammarström
The research effort in mesoporous p-type semiconductors is increasing due to their potential application in photoelectrochemical energy conversion devices. In this paper an electron-hole pair is created by band-gap excitation of NiO nanoparticles and the dynamics of the electron and the hole is followed until their recombination. By spectroscopic characterization it was found that surface Ni3+ states work as traps for both electrons and holes. The trapped electron was assigned to a Ni2+ state and the trapped hole to a "Ni4+ " state positioned close to the valence band edge...
January 7, 2018: Chemical Science
Miguel Gonzalez-Andrades, Roholah Sharifi, Mohammad-Mirazul Islam, Thibaut Divoux, Michael Haist, Eleftherios Paschalis, Larisa Gelfand, Shamina Mamodaly, Luca Di Cecilia, Andrea Cruzat, Franz-Josef Ulm, James Chodosh, Francois Delori, Claes H Dohlman
PURPOSE: To make the Boston keratoprosthesis (B-KPro), together with its carrier corneal graft, more easily procured, transported and stored, as well as less expensive, easier for the surgeon to implant and safer for the patient, it is proposed that the B-KPro-graft combination be pre-assembled by an expert technician, followed by sterilization with gamma ray irradiation (GI) allowing long-term storage at room temperature. For this to be possible, it must be shown that the B-KPro itself (not only the graft) remains unharmed by the irradiation...
April 5, 2018: Ocular Surface
Sergio F Bodini, Marzio Malizia, Annalisa Tortelli, Luca Sanfilippo, Xingpeng Zhou, Roberta Arosio, Marzia Bernasconi, Stefano Di Lucia, Angela Manenti, Pompeo Moscetta
A novel tool, the DAMTA analyzer (Device for Analytical Monitoring and Toxicity Assessment), designed for fully automated toxicity measurements based on luminescent bacteria as well as for concomitant determination of chemical parameters, was developed and field-tested. The instrument is a robotic water analyzer equipped with a luminometer and a spectrophotometer, integrated on a thermostated reaction plate which contains a movable carousel with 80 cuvettes. Acute toxicity is measured on-line using a wild type Photobacterium phosphoreum strain with measurable bioluminescence and unaltered sensitivity to toxicants lasting up to ten days...
April 5, 2018: Ecotoxicology and Environmental Safety
Antonello Maria Messina, Luca Marini, Ettore Marini
With the increasing popularity of dental implants, the removal of fractured implants has become a major challenge for clinicians. Several tools can be used for the removal of osseointegrated implants; however, few of these have the characteristics of easy control, selective cutting, and rapid healing. In this study, the authors describe a step-by-step technique for the removal of osseointegrated fractured implants via multiple peri-implant osteotomies performed using a piezoelectric device and appropriate inserts...
April 4, 2018: Journal of Craniofacial Surgery
Alexander Epping, Luca Banszerus, Johannes Guettinger, Luisa Krueckeberg, Kenji Watanabe, Takashi Taniguchi, Fabian Hassler, Bernd Beschoten, Christoph Stampfer
We present a device scheme to explore mesoscopic transport through molybdenum disulfide (MoS<sub>2</sub>) constrictions using photodoping. The devices are based on van-der-Waals heterostructures where few-layer MoS<sub>2</sub> flakes are partially encapsulated by hexagonal boron nitride (hBN) and covered by a few-layer graphene flake to fabricate electrical contacts. Since the as-fabricated devices are insulating at low temperatures, we use photo-induced remote doping in the hBN substrate to create free charge carriers in the MoS<sub>2</sub> layer...
April 5, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Pietro Cataldi, Simeone Dussoni, Luca Ceseracciu, Marco Maggiali, Lorenzo Natale, Giorgio Metta, Athanassia Athanassiou, Ilker S Bayer
Stretchable capacitive devices are instrumental for new-generation multifunctional haptic technologies particularly suited for soft robotics and electronic skin applications. A majority of elongating soft electronics still rely on silicone for building devices or sensors by multiple-step replication. In this study, fabrication of a reliable elongating parallel-plate capacitive touch sensor, using nitrile rubber gloves as templates, is demonstrated. Spray coating both sides of a rubber piece cut out of a glove with a conductive polymer suspension carrying dispersed carbon nanofibers (CnFs) or graphene nanoplatelets (GnPs) is sufficient for making electrodes with low sheet resistance values (≈10 Ω sq-1 )...
February 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Martin K Schmid, Livia Faes, Lucas M Bachmann, Michael A Thiel
Objective: To evaluate diagnostic accuracy of a new self-monitoring device using a Vernier hyperacuity alignment task. Method: A total of 11 wet Age-Related Macular Degeneration (AMD) patients and 9 controls contributing 37 eyes were consecutively enrolled into this prospective diagnostic case-control study at the retina centre of the Cantonal Hospital Lucerne, Switzerland. Vernier acuity testing (index test) and Optical Coherence Tomography (OCT, reference test) were performed in all participants...
2018: Open Ophthalmology Journal
Lucas G Cavallaro, Cesare Hassan, Pierenrico Lecis, Ermenegildo Galliani, Elisabetta Dal Pont, Paolo Iuzzolino, Claudia Roldo, Fabio Soppelsa, Bastianello Germanà
Background and study aims:  Colorectal cancer (CRC) screening with biennial fecal occult blood test has been shown to reduce CRC mortality. For the effectiveness of the CRC screening program is crucial that a high-quality colonoscopy with a high adenoma detection rate (ADR) be performed. To improve ADR, various endoscopic devices have been developed. Endocuff, an endoscopic cap with finger-like projections, has been shown to improve ADR. The aim of this study was to compare in an organized CRC screening program ADR, advanced adenoma detection rate (AADR) and mean number of adenomas per patient (MAP) using standard colonoscopy (SC) and Endocuff-assisted colonoscopy (EAC)...
April 2018: Endoscopy International Open
Matus Stredansky, Alessandro Sala, Tommaso Fontanot, Roberto Costantini, Cristina Africh, Giovanni Comelli, Luca Floreano, Alberto Morgante, Albano Cossaro
The synthesis and preliminary characterization of a boron-based 2D framework are presented. The peculiar electronic and morphological properties of this compound, together with its facile formation process, enable it to be used as a novel smart material for the design of electronic devices.
April 3, 2018: Chemical Communications: Chem Comm
Donatas Gesevičius, Antonia Neels, Sandra Jenatsch, Erwin Hack, Lucas Viani, Stavros Athanasopoulos, Frank Nüesch, Jakob Heier
A symmetrical cyanine dye chromophore is modified with different counteranions to study the effect on crystal packing, polarizability, thermal stability, optical properties, light absorbing layer morphology, and organic photovoltaic (OPV) device parameters. Four sulfonate-based anions and the bulky bistriflylimide anion are introduced to the 2-[5-(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)-1,3-pentadien-1-yl]-1,3,3-trimethyl-3H-indolium chromophore using an Amberlyst A26 (OH- form) anion exchanger. Anionic charge distribution clearly correlates with device performance, whereby an average efficiency of 2% was reached in a standard bilayer organic solar...
February 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Niels C Munksgaard, Alexander W Cheesman, Andrew Gray-Spence, Lucas A Cernusak, Michael I Bird
RATIONALE: Continuous measurement of stable O and H isotope compositions in water vapour requires automated calibration for remote field deployments. We developed a new low-cost device for calibration of both water vapour mole fraction and isotope composition. METHODS: We coupled a commercially available dew point generator (DPG) to a laser spectrometer and developed hardware for water and air handling along with software for automated operation and data processing...
March 30, 2018: Rapid Communications in Mass Spectrometry: RCM
Srinidhi Nagaraja, Stacey J L Sullivan, Phillip R Stafford, Anne D Lucas, Elon Malkin
Although nitinol is used widely in percutaneous cardiovascular interventions, a causal relationship between nickel released from implanted cardiovascular devices and adverse systemic or local biological responses has not been established. The objective of this study was to investigate the relationship between nitinol surface processing, in-vivo nickel release, and biocompatibility. Nitinol stents manufactured using select surface treatments were implanted into the iliac arteries of minipigs for 6 months. Clinical chemistry profile, complete blood count, serum and urine nickel analyses were performed periodically during the implantation period...
March 26, 2018: Acta Biomaterialia
Roberto Di Bartolomeo, Giacomo Murana, Luca Di Marco, Jacopo Alfonsi, Gregorio Gliozzi, Ciro Amodio, Alessandro Leone, Davide Pacini
The elephant trunks, either conventional or frozen represent the major technical improvements in the treatment of complex thoracic aortic disease. In the last decades, these useful techniques progressively evolved along with the introduction of new devices to facilitate the procedure and ameliorate post-operative results. The latest multi-branched hybrid FET prostheses give us the opportunity to greatly facilitate graft implantation and reduce operative times. The following review will provide an overview of the FET technique throughout the current available devices, possible surgical indications and principal surgical steps...
March 28, 2018: General Thoracic and Cardiovascular Surgery
Lucas Phil, Muhammad Naveed, Imran Shair Mohammad, Li Bo, Di Bin
Being the most versatile biopolymer, chitooligosaccharide/chitosan oligosaccharide (COS) has been extensively studied for a range of exceptional biological activities and potential developments of novel medical devices and systems in biomedical and pharmaceutical fields. While possessing intrinsic biocompatibility, mucoadhesiveness, and non-toxicity it gained more interests in the biomedical development of novel systems, devices, and pharmaceutical formulations. The bioactive relativity of chitosan and COS are of highly significant and thus explored in this paper while highlighting its multiple biological activities and promising biomedical applications...
March 23, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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