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https://www.readbyqxmd.com/read/29442518/large-area-high-performance-flexible-pressure-sensor-with-carbon-nanotube-active-matrix-for-electronic-skin
#1
Luca Nela, Jianshi Tang, Qing Cao, George S Tulevski, Shu-Jen Han
Artificial "electronic skin" is of great interest for mimicking the functionality of human skin, such as tactile pressure sensing. Several important performance metrics include mechanical flexibility, operation voltage, sensitivity and accuracy, as well as response speed. In this paper, we demonstrate a large-area high-performance flexible pressure sensor built on an active matrix of 16×16 carbon nanotube thin-film transistors (CNT TFTs). Made from highly-purified solution tubes, the active matrix exhibits superior flexible TFT performance with high mobility and large current density, along with a high device yield of nearly 99% over 4-inch sample area...
February 14, 2018: Nano Letters
https://www.readbyqxmd.com/read/29440943/state-of-the-art-of-robotic-surgery-related-to-vision-brain-and-eye-applications-of-newly-available-devices
#2
REVIEW
Raffaele Nuzzi, Luca Brusasco
Background: Robot-assisted surgery has revolutionized many surgical subspecialties, mainly where procedures have to be performed in confined, difficult to visualize spaces. Despite advances in general surgery and neurosurgery, in vivo application of robotics to ocular surgery is still in its infancy, owing to the particular complexities of microsurgery. The use of robotic assistance and feedback guidance on surgical maneuvers could improve the technical performance of expert surgeons during the initial phase of the learning curve...
2018: Eye and Brain
https://www.readbyqxmd.com/read/29438080/thrombus-neutrophil-extracellular-traps-content-impair-tpa-induced-thrombolysis-in-acute-ischemic-stroke
#3
Celina Ducroux, Lucas Di Meglio, Stephane Loyau, Sandrine Delbosc, William Boisseau, Catherine Deschildre, Malek Ben Maacha, Raphael Blanc, Hocine Redjem, Gabriele Ciccio, Stanislas Smajda, Robert Fahed, Jean-Baptiste Michel, Michel Piotin, Laurence Salomon, Mikael Mazighi, Benoit Ho-Tin-Noe, Jean-Philippe Desilles
BACKGROUND AND PURPOSE: Neutrophil Extracellular Traps (NETs) are DNA extracellular networks decorated with histones and granular proteins produced by activated neutrophils. NETs have been identified as major triggers and structural factors of thrombosis. A recent study designated extracellular DNA threads from NETs as a potential therapeutic target for improving tissue-type plasminogen activator (tPA)-induced thrombolysis in acute coronary syndrome. The aim of this study was to assess the presence of NETs in thrombi retrieved during endovascular therapy in patients with acute ischemic stroke (AIS) and their impact on tPA-induced thrombolysis...
February 8, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29421916/a-prospective-controlled-assessment-of-the-technical-characteristics-of-a-novel-forward-viewing-echoendoscope
#4
Ángel Cañete Ruiz, Jose Ramón Foruny Olcina, Fernando González-Panizo, Alejandra Caminoa, Antonia Navarro, Diego Juzgado Lucas, Agustín Albillos Martínez, Enrique Vázquez Sequeiros
INTRODUCTION: endoscopic ultrasound (EUS) is a highly useful technique for the diagnosis and management of different gastrointestinal (GI) tract conditions. OBJECTIVE: to prospectively assess the clinical usefulness of a novel forward-viewing echoendoscope (FV-CLA). METHODS: this was a cross-sectional observational study. All patients that underwent EUS over a two-month period were considered for the study. All mediastinal, perigastric and periduodenal stations were consistently assessed with a rating from 0 to 10 points with regard to the ease to obtain ultrasonographic sections and the quality of ultrasound images...
February 9, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29416554/2017-wses-guidelines-for-the-management-of-iatrogenic-colonoscopy-perforation
#5
REVIEW
Nicola de'Angelis, Salomone Di Saverio, Osvaldo Chiara, Massimo Sartelli, Aleix Martínez-Pérez, Franca Patrizi, Dieter G Weber, Luca Ansaloni, Walter Biffl, Offir Ben-Ishay, Miklosh Bala, Francesco Brunetti, Federica Gaiani, Solafah Abdalla, Aurelien Amiot, Hany Bahouth, Giorgio Bianchi, Daniel Casanova, Federico Coccolini, Raul Coimbra, Gian Luigi de'Angelis, Belinda De Simone, Gustavo P Fraga, Pietro Genova, Rao Ivatury, Jeffry L Kashuk, Andrew W Kirkpatrick, Yann Le Baleur, Fernando Machado, Gustavo M Machain, Ronald V Maier, Alain Chichom-Mefire, Riccardo Memeo, Carlos Mesquita, Juan Carlos Salamea Molina, Massimiliano Mutignani, Ramiro Manzano-Núñez, Carlos Ordoñez, Andrew B Peitzman, Bruno M Pereira, Edoardo Picetti, Michele Pisano, Juan Carlos Puyana, Sandro Rizoli, Mohammed Siddiqui, Iradj Sobhani, Richard P Ten Broek, Luigi Zorcolo, Maria Clotilde Carra, Yoram Kluger, Fausto Catena
Iatrogenic colonoscopy perforation (ICP) is a severe complication that can occur during both diagnostic and therapeutic procedures. Although 45-60% of ICPs are diagnosed by the endoscopist while performing the colonoscopy, many ICPs are not immediately recognized but are instead suspected on the basis of clinical signs and symptoms that occur after the endoscopic procedure. There are three main therapeutic options for ICPs: endoscopic repair, conservative therapy, and surgery. The therapeutic approach must vary based on the setting of the diagnosis (intra- or post-colonoscopy), the type of ICP, the characteristics and general status of the patient, the operator's level of experience, and surgical device availability...
2018: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/29411962/oxygen-impurities-link-bistability-and-magnetoresistance-in-organic-spin-valves
#6
Ilaria Bergenti, Francesco Borgatti, Marco Calbucci, Alberto Riminucci, Raimondo Cecchini, Patrizio Graziosi, Donald MacLaren, Angelo Giglia, Jean-Pascal Rueff, Denis Céolin, Luca Pasquali, Valentin Alek Dediu
Vertical cross-bar devices based on manganite and cobalt injecting electrodes and metal-quinoline molecular transport layer are known to manifest both magnetoresistance and electrical bistability. The two effects are strongly interwoven, inspiring new device applications such as electrical control of the magnetoresistance and magnetic modulation of bistability. To investigate the full device functionality, we first identify the mechanism responsible for electrical switching by associating the electrical conductivity and the impedance behavior with chemical states of buried layers obtained by in operando photoelectron spectroscopy...
February 7, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29401783/design-of-a-compact-cmos-compatible-photonic-antenna-by-topological-optimization
#7
Julián L Pita, Ivan Aldaya, Paulo Dainese, Hugo E Hernandez-Figueroa, Lucas H Gabrielli
Photonic antennas are critical in applications such as spectroscopy, photovoltaics, optical communications, holography, and sensors. In most of those applications, metallic antennas have been employed due to their reduced sizes. Nevertheless, compact metallic antennas suffer from high dissipative loss, wavelength-dependent radiation pattern, and they are difficult to integrate with CMOS technology. All-dielectric antennas have been proposed to overcome those disadvantages because, in contrast to metallic ones, they are CMOS-compatible, easier to integrate with typical silicon waveguides, and they generally present a broader wavelength range of operation...
February 5, 2018: Optics Express
https://www.readbyqxmd.com/read/29401306/subaxillary-approach-to-cardiac-electronic-device-implantation-using-a-single-surgical-incision-a-single-centre-experience
#8
Bruna Bolzan, Martina Morosato, Domenico Caponi, Luca Tomasi, Giuseppe Silvestre, Giovanni Morani
OBJECTIVES: Pacemakers and implantable cardioverter defibrillators have become more common in younger individuals, owing to broader indications and technological advances. Our goal was to report our long-term experience of implanting cardiac devices in young adults via a subaxillary approach with a hidden single incision, to minimize the aesthetic impact of the device. METHODS: From 2003 to 2012, 23 patients underwent cardiac device implantation via a subaxillary approach while they were under general anaesthesia...
February 1, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29398575/rigor-and-reproducibility-in-research-with-transcranial-electrical-stimulation-an-nimh-sponsored-workshop
#9
REVIEW
Marom Bikson, Andre R Brunoni, Leigh E Charvet, Vincent P Clark, Leonardo G Cohen, Zhi-De Deng, Jacek Dmochowski, Dylan J Edwards, Flavio Frohlich, Emily S Kappenman, Kelvin O Lim, Colleen Loo, Antonio Mantovani, David P McMullen, Lucas C Parra, Michele Pearson, Jessica D Richardson, Judith M Rumsey, Pejman Sehatpour, David Sommers, Gozde Unal, Eric M Wassermann, Adam J Woods, Sarah H Lisanby
BACKGROUND: Neuropsychiatric disorders are a leading source of disability and require novel treatments that target mechanisms of disease. As such disorders are thought to result from aberrant neuronal circuit activity, neuromodulation approaches are of increasing interest given their potential for manipulating circuits directly. Low intensity transcranial electrical stimulation (tES) with direct currents (transcranial direct current stimulation, tDCS) or alternating currents (transcranial alternating current stimulation, tACS) represent novel, safe, well-tolerated, and relatively inexpensive putative treatment modalities...
December 29, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29395757/standardized-model-of-porcine-resuscitation-using-a-custom-made-resuscitation-board-results-in-optimal-hemodynamic-management
#10
Jakob Wollborn, Eva Ruetten, Bjoern Schlueter, Joerg Haberstroh, Ulrich Goebel, Martin A Schick
AIM: Standardized modeling of cardiac arrest and cardiopulmonary resuscitation (CPR) is crucial to evaluate new treatment options. Experimental porcine models are ideal, closely mimicking human-like physiology. However, anteroposterior chest diameter differs significantly, being larger in pigs and thus poses a challenge to achieve adequate perfusion pressures and consequently hemodynamics during CPR, which are commonly achieved during human resuscitation. The aim was to prove that standardized resuscitation is feasible and renders adequate hemodynamics and perfusion in pigs, using a specifically designed resuscitation board for a pneumatic chest compression device...
January 22, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29389805/radiotherapy-and-risk-of-implantable-cardioverter-defibrillator-malfunctions-experimental-data-from-direct-exposure-at-increasing-doses
#11
Massimo Zecchin, Jessica Artico, Gaetano Morea, Mara Severgnini, Elisabetta Bianco, Antonio De Luca, Anna Zorzin Fantasia, Luca Salvatore, Vittorino Milan, Matteo Lucarelli, Roberta Dissegna, Antonio Cannatà, Gianfranco Sinagra
AIM: During radiotherapy, in patients with implantable cardioverter-defibrillators (ICDs) malfunctions are considered more likely if doses more than 2 Gy reach the ICD site; however, most malfunctions occur with high-energy (>10 MV) radiations, and the risk is less defined using 6-MV linear accelerators. The purpose of the study is to experimentally evaluate the occurrence of malfunctions in ICDs radiated with a 6-MV linear accelerator at increasing photon doses. METHODS: Thirty-two ICDs from all manufacturers (31 explanted and one demo) were evaluated; all devices with a sufficient battery charge underwent multiple radiations with a 6-MV photon beam reaching a cumulative dose at ICD site of 0...
January 30, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29386562/polarization-maintaining-reflection-mode-thz-time-domain-spectroscopy-of-a-polyimide-based-ultra-thin-narrow-band-metamaterial-absorber
#12
Maria Denise Astorino, Renato Fastampa, Fabrizio Frezza, Luca Maiolo, Marco Marrani, Mauro Missori, Marco Muzi, Nicola Tedeschi, Andrea Veroli
This paper reports the design, the microfabrication and the experimental characterization of an ultra-thin narrow-band metamaterial absorber at terahertz frequencies. The metamaterial device is composed of a highly flexible polyimide spacer included between a top electric ring resonator with a four-fold rotational symmetry and a bottom ground plane that avoids misalignment problems. Its performance has been experimentally demonstrated by a custom polarization-maintaining reflection-mode terahertz time-domain spectroscopy system properly designed in order to reach a collimated configuration of the terahertz beam...
January 31, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29384755/direct-echocardiographic-imaging-of-berlin-heart-valves-can-aid-in-early-detection-of-berlin-heart-valve-dysfunction
#13
Gary S Beasley, Kristen Nelson-McMillan, Luca Vricella, William R Thompson, William Ravekes
Mechanical circulatory support options remain limited for pediatric patients, especially neonates. The only FDA-approved pediatric device remains the Berlin Heart EXCOR, which unfortunately carries with it a 20-30% risk of neurologic complications, such as strokes. We demonstrate a new technique of direct echocardiographic color-Doppler imaging of the Berlin Heart valves to detect valve regurgitation. Increases in valve regurgitation could indicate issues with pump-valve thrombosis or increased afterload leading to valve insufficiency...
January 30, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29382237/in-vivo-nose-to-brain-delivery-of-the-hydrophilic-antiviral-ribavirin-by-microparticle-agglomerates
#14
Alessandro Giuliani, Anna Giulia Balducci, Elisa Zironi, Gaia Colombo, Fabrizio Bortolotti, Luca Lorenzini, Viola Galligioni, Giampiero Pagliuca, Alessandra Scagliarini, Laura Calzà, Fabio Sonvico
Nasal administration has been proposed as a potential approach for the delivery of drugs to the central nervous system. Ribavirin (RBV), an antiviral drug potentially useful to treat viral infections both in humans and animals, has been previously demonstrated to attain several brain compartments after nasal administration. Here, a powder formulation in the form of agglomerates comprising micronized RBV and spray-dried microparticles containing excipients with potential absorption enhancing properties, i.e...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29378312/under-dilated-tips-associate-with-efficacy-and-reduced-encephalopathy-in-a-prospective-non-randomized-study-of-patients-with-cirrhosis
#15
Filippo Schepis, Francesco Vizzutti, Guadalupe Garcia-Tsao, Guido Marzocchi, Luigi Rega, Nicola De Maria, Tommaso Di Maira, Stefano Gitto, Cristian Caporali, Stefano Colopi, Mario De Santis, Umberto Arena, Antonio Rampoldi, Aldo Airoldi, Alessandro Cannavale, Fabrizio Fanelli, Cristina Mosconi, Matteo Renzulli, Roberto Agazzi, Roberto Nani, Pietro Quaretti, Ilaria Fiorina, Lorenzo Moramarco, Roberto Miraglia, Angelo Luca, Raffaele Bruno, Stefano Fagiuoli, Rita Golfieri, Pietro Torricelli, Fabrizio Di Benedetto, Luca Saverio Belli, Federico Banchelli, Giacomo Laffi, Fabio Marra, Erica Villa
BACKGROUND & AIMS: Portosystemic encephalopathy (PSE) is a major complication of trans-jugular intrahepatic porto-systemic shunt (TIPS) placement. Most devices are self-expandable polytetrafluoroethylene-covered stent grafts (PTFE-SGs) that are dilated to their nominal diameter (8 or 10 mm). We investigated whether PTFE-SGs dilated to a smaller caliber (under-dilated TIPS) reduce PSE yet maintain clinical and hemodynamic efficacy. We also studied whether under-dilated TIPS self-expand to nominal diameter over time...
January 25, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29364837/volumetric-modulated-arc-radio-therapy-in-pets-treatment-the-la-cittadina-fondazione-experience
#16
REVIEW
Mario Dolera, Luca Malfassi, Nancy Carrara, Sara Finesso, Silvia Marcarini, Giovanni Mazza, Simone Pavesi, Massimo Sala, Gaetano Urso
Volumetric Modulated Arc Therapy (VMAT) is a modern technique, widely used in human radiotherapy, which allows a high dose to be delivered to tumor volumes and low doses to the surrounding organs at risk (OAR). Veterinary clinics takes advantage of this feature due to the small target volumes and distances between the target and the OAR. Sparing the OAR permits dose escalation, and hypofractionation regimens reduce the number of treatment sessions with a simpler manageability in the veterinary field. Multimodal volumes definition is mandatory for the small volumes involved and a positioning device precisely reproducible with a setup confirmation is needed before each session for avoiding missing the target...
January 24, 2018: Cancers
https://www.readbyqxmd.com/read/29359881/three-year-follow-up-of-temporary-implantable-nitinol-device-tind%C3%A2-implantation-for-the-treatment-of-benign-prostatic-obstruction
#17
Francesco Porpiglia, Cristian Fiori, Riccardo Bertolo, Andrea Giordano, Enrico Checcucci, Diletta Garrou, Giovanni Cattaneo, Stefano De Luca, Daniele Amparore
OBJECTIVES: To report 3-year follow-up results of the first implantations with the Temporary Implantable Nitinol Device (TIND - Meditate® ) for the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). PATIENTS AND METHODS: Thirty-two patients with LUTS were enrolled in this prospective study. The study was approved by the local Ethics Committee. Inclusion criteria were: age > 50 years, IPSS scores ≥ 10, peak urinary flow (Qmax) ≤ 12 ml/sec, prostate volume < 60 cc...
January 23, 2018: BJU International
https://www.readbyqxmd.com/read/29358003/predicting-device-failure-after-percutaneous-repair-of-functional-mitral-regurgitation-in-advanced-heart-failure-implications-for-patient-selection
#18
Davide Stolfo, Antonio De Luca, Gaetano Morea, Marco Merlo, Giancarlo Vitrella, Thomas Caiffa, Giulia Barbati, Serena Rakar, Renata Korcova, Andrea Perkan, Bruno Pinamonti, Aniello Pappalardo, Alessandra Berardini, Elena Biagini, Francesco Saia, Francesco Grigioni, Claudio Rapezzi, Gianfranco Sinagra
BACKGROUND: Patients with heart failure (HF) and severe symptomatic functional mitral regurgitation (FMR) may benefit from MitraClip implantation. With increasing numbers of patients being treated the success of procedure becomes a key issue. We sought to investigate the pre-procedural predictors of device failure in patients with advanced HF treated with MitraClip. METHODS: From April 2012 to November 2016, 76 patients with poor functional class (NYHA class III-IV) and severe left ventricular (LV) remodeling underwent MitraClip implantation at University Hospitals of Trieste and Bologna (Italy)...
January 6, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29351759/tracheal-intubation-in-critically-ill-patients-a-comprehensive-systematic-review-of-randomized-trials
#19
Luca Cabrini, Giovanni Landoni, Martina Baiardo Radaelli, Omar Saleh, Carmine D Votta, Evgeny Fominskiy, Alessandro Putzu, Cézar Daniel Snak de Souza, Massimo Antonelli, Rinaldo Bellomo, Paolo Pelosi, Alberto Zangrillo
BACKGROUND: We performed a systematic review of randomized controlled studies evaluating any drug, technique or device aimed at improving the success rate or safety of tracheal intubation in the critically ill. METHODS: We searched PubMed, BioMed Central, Embase and the Cochrane Central Register of Clinical Trials and references of retrieved articles. Finally, pertinent reviews were also scanned to detect further studies until May 2017. The following inclusion criteria were considered: tracheal intubation in adult critically ill patients; randomized controlled trial; study performed in Intensive Care Unit, Emergency Department or ordinary ward; and work published in the last 20 years...
January 20, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29345585/mandatory-reporting-of-coronary-artery-calcifications-incidentally-noted-on-chest-multi-detector-computed-tomography-a-multicentre-experience
#20
Salvatore Cappabianca, Maria Paola Belfiore, Alfonso Reginelli, Raffaella Capasso, Alessandra Del Prete, Mario Petrillo, Paola Mascia, Claudia Rossi, Francesco Romano, Massimo De Filippo, Michele Scialpi, Felice Gragnano, Paolo Calabro, Giuseppe Belfiore, Luca Brunese, Roberto Grassi, Antonio Rotondo
BACKGROUND Coronary artery calcifications (CACs) are associated with coronary atherosclerosis and cardiovascular (CV) events. In "non-cardiovascular" settings, CACs can be easily detected on chest multi-detector computed tomography (MDCT). Their evaluation may help to better stratify CV risk in the general population, especially for primary prevention. AIMS We retrospectively evaluated the relationship between CAC distribution and CV risk, determined by Framingham Risk Score (FRS), in a cohort of patients who underwent chest MDCT performed for several clinical indications...
January 16, 2018: Current Vascular Pharmacology
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