Hillel S Panitch, Ronald A Thisted, Richard A Smith, Daniel R Wynn, James P Wymer, Anat Achiron, Timothy L Vollmer, Raul N Mandler, Dennis W Dietrich, Malcolm Fletcher, Laura E Pope, James E Berg, Ariel Miller
OBJECTIVE: To evaluate the efficacy and safety of DM/Q (capsules containing dextromethorphan [DM] and quinidine [Q]) compared with placebo, taken twice daily, for the treatment of pseudobulbar affect over a 12-week period in multiple sclerosis patients. METHODS: A total of 150 patients were randomized in a double-blind, placebo-controlled study to assess pseudobulbar affect with the validated Center for Neurologic Study-Lability Scale. Each patient also recorded the number of episodes experienced between visits, estimated quality of life and quality of relationships on visual analog scales, and completed a pain rating scale...
May 2006: Annals of Neurology