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https://www.readbyqxmd.com/read/29684199/patterns-of-ses-health-disparities-among-older-adults-in-three-upper-middle-and-two-high-income-countries
#1
Mary McEniry, Rafael Samper-Ternent, Carmen Elisa Flórez, Renata Pardo, Carlos Cano-Gutierrez
Objectives: To examine the socioeconomic status (SES) health gradient for obesity, diabetes, and hypertension within a diverse group of health outcomes and behaviors among older adults (60+) in upper middle-income countries benchmarked with high-income countries. Method : We used data from three upper middle-income settings (Colombia-SABE-Bogotá, Mexico-SAGE, and South Africa-SAGE) and two high-income countries (England-ELSA and US-HRS) to estimate logistic regression models using age, gender, and education to predict health and health behaviors...
April 19, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29684077/medication-burden-attributable-to-chronic-co-morbid-conditions-in-the-very-old-and-vulnerable
#2
Kelly L Moore, Kanan Patel, W John Boscardin, Michael A Steinman, Christine Ritchie, Janice B Schwartz
OBJECTIVE: Polypharmacy is common in older patients but relationships between polypharmacy and common co-morbid conditions have not been elucidated. Our goal was to determine relationships between daily oral medication use and common co-morbid disease dyads and triads using comprehensive medication and diagnostic data from a national sample of nursing homes (NH). DESIGN: Retrospective, cross-sectional study. SETTING: Nationally representative sample of U...
2018: PloS One
https://www.readbyqxmd.com/read/29682584/patient-related-determinants-of-glycaemic-control-in-people-with-type-2-diabetes-in-the-gulf-cooperation-council-countries-a-systematic-review
#3
REVIEW
Mohammed J Alramadan, Afsana Afroz, Sultana Monira Hussain, Mohammed Ali Batais, Turky H Almigbal, Hassan Ahmad Al-Humrani, Ahmed Albaloshi, Lorena Romero, Dianna J Magliano, Baki Billah
The aim of this systematic review is to assess patient-related factors affecting glycaemic control among people with type 2 diabetes in the Arabian Gulf Council countries. MEDLINE, Embase, PsycINFO, CINAHL, and Cochrane CENTRAL databases were searched from their date of inception to May 2016. Two researchers independently identified eligible studies and assessed the risk of bias. A total of 13 studies met the inclusion criteria. One study was population based, six recruited participants from multiple centres, and the remaining were single centred...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29681509/regional-differences-in-brain-glucose-metabolism-determined-by-imaging-mass-spectrometry
#4
André Kleinridders, Heather A Ferris, Michelle L Reyzer, Michaela Rath, Marion Soto, M Lisa Manier, Jeffrey Spraggins, Zhihong Yang, Robert C Stanton, Richard M Caprioli, C Ronald Kahn
OBJECTIVE: Glucose is the major energy substrate of the brain and crucial for normal brain function. In diabetes, the brain is subject to episodes of hypo- and hyperglycemia resulting in acute outcomes ranging from confusion to seizures, while chronic metabolic dysregulation puts patients at increased risk for depression and Alzheimer's disease. In the present study, we aimed to determine how glucose is metabolized in different regions of the brain using imaging mass spectrometry (IMS)...
April 6, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29681241/differences-in-the-health-transition-patterns-of-migrants-and-non-migrants-aged-50-and-older-in-southern-and-western-europe-2004-2015
#5
Matias Reus-Pons, Clara H Mulder, Eva U B Kibele, Fanny Janssen
BACKGROUND: Most previous research on migrant health in Europe has taken a cross-sectional perspective, without a specific focus on the older population. Having knowledge about inequalities in health transitions over the life course between migrants and non-migrants, including at older ages, is crucial for the tailoring of policies to the demands of an ageing and culturally diverse society. We analyse differences in health transitions between migrants and non-migrants, specifically focusing on the older population in Europe...
April 23, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29680319/comrade-a-randomized-trial-of-an-individually-tailored-integrated-care-intervention-for-uncontrolled-type-2-diabetes-with-depression-and-or-distress-in-the-rural-southeastern-us
#6
Lesley D Lutes, Doyle M Cummings, Kerry Littlewood, Chelsey Solar, Marissa Carraway, Kari Kirian, Shivajirao Patil, Alyssa Adams, Stefanie Ciszewski, Bertha Hambidge
BACKGROUND: Emerging evidence suggests that people living with Type 2 diabetes mellitus (T2D) are also at greater risk for depression and distress. If left untreated, these comorbid mental health concerns can have long-lasting impacts on medical and physical health outcomes. DESIGN: This prospective trial randomized rural men and women with uncontrolled T2D (HbA1c ≥ 7.0) who screened positive for co-morbid depressive (PHQ-2 > 3) or distress (DDS-2 > 3) symptoms in a primary medical care setting to receive either: 1) 16 sessions of cognitive and/or behavioral intervention tailored to symptom severity across 12 months along with routine medical care, or 2) usual primary care...
April 19, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29675748/association-between-obesity-and-depressive-symptoms-in-mexican-population
#7
Gerardo A Zavala, Spyros Kolovos, Alessandro Chiarotto, Judith E Bosmans, Maiza Campos-Ponce, Jorge L Rosado, Olga P Garcia
PURPOSE: Obesity and depression are among the leading causes of disability in Mexico, but their association has not been explored yet. The aim of the current study was to investigate the association between obesity and depression in Mexican population. METHODS: We used data from the health and nutrition survey (ENSANUT 2012), which is representative of the Mexican population. Obesity was determined using the body mass index (BMI) and abdominal obesity by measuring waist circumference...
April 19, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29673896/health-beliefs-and-medication-adherence-in-black-patients-with-diabetes-and-mild-cognitive-impairment
#8
Barry W Rovner, Robin J Casten
OBJECTIVES: To evaluate determinants of medication adherence and glycemic control in black patients with diabetes and mild cognitive impairment (MCI). METHODS: Cross-sectional study of 143 participants with mean age of 68.8 (SD: 6.7) years; 66.4% were women. RESULTS: Eighty-seven participants (60.8%) self-reported medication nonadherence; they had more negative beliefs about medicines, greater diabetes-related distress, and more difficulty with daily living activities and affording medications than adherent participants...
March 23, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29673848/overcoming-missed-opportunities-in-diabetes-management-to-improve-outcomes-for-hospitalized-patients-with-diabetes
#9
Michael Oravec, James Salem, Jason Kunz, Michelle Cudnik, Lynn Clough, Robert Woods, Megan Elavsky
AIMS: The purpose of this study is to assess the impact of hospitalization on 6-12 month medication adjustment and glycemic control. METHODS: We conducted a retrospective cohort study of hospitalized and non-hospitalized patients with diabetes of an internal medicine residency continuity clinic. Patients had baseline and outcome HbA1c taken 6-12 months apart. Multivariate linear regression was used to model predictors of HbA1c change from baseline to outcome. Multivariate logistic regression was used to model predictors of medication adjustment between baseline and outcome clinic visits...
April 16, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29672099/is-the-association-between-depressive-symptoms-and-glucose-bidirectional-a-population-based-study
#10
Karolina Wesołowska, Marko Elovainio, Taina Hintsa, Markus Jokela, Laura Pulkki-Råback, Jari Lipsanen, Markus Juonala, Olli Raitakari, Liisa Keltikangas-Järvinen
OBJECTIVE: Depressive symptoms have been associated with Type 2 diabetes, but the temporal direction of this association and the underlying mechanisms remain unclear. The present study examined a potential bidirectional association between depressive symptoms and glucose levels in women and men, and the factors mediating this association. METHOD: The participants were from the Cardiovascular Risk in Young Finns Study, a prospective, population-based, cohort study (N = 2,534)...
April 19, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29671894/select-medications-that-unexpectedly-lower-hba1c-levels
#11
F Tillman, J Kim
WHAT IS KNOWN AND OBJECTIVE: A variety of medication classes are available for diabetes; however, treatment options become limited due to adverse effect profiles and cost. Current diabetes guidelines include agents not originally developed for diabetes treatment, bromocriptine and colesevelam. COMMENT: Other non-diabetes medications demonstrating haemoglobin A1c lowering, including agents for weight loss, depression, anaemia and coronary artery disease, are described in this review article...
April 19, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29671539/evaluation-of-suspected-dementia
#12
Nathan Falk, Ariel Cole, T Jason Meredith
Dementia is a significant and costly health condition that affects 5 million adults and is the fifth leading cause of death among Americans older than 65 years. The prevalence of dementia will likely increase in the future because the number of Americans older than 65 years is expected to double by 2060. Risk factors for dementia include age; family history of dementia; personal history of cardiovascular disease, cerebrovascular disease, diabetes mellitus, or midlife obesity; use of anticholinergic medications; apolipoprotein E4 genotype; and lower education level...
March 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29671532/vitamin-d-screening-and-supplementation-in-community-dwelling-adults-common-questions-and-answers
#13
Michael L LeFevre, Nicholas M LeFevre
Measurement of vitamin D levels and supplementation with oral vitamin D have become commonplace, although clinical trials have not demonstrated health benefits. The usefulness of serum 25-hydroxyvitamin D levels to assess adequate exposure to vitamin D is hampered by variations in measurement technique and precision. Serum levels less than 12 ng per mL reflect inadequate vitamin D intake for bone health. Levels greater than 20 ng per mL are adequate for 97.5% of the population. Routine vitamin D supplementation does not prolong life, decrease the incidence of cancer or cardiovascular disease, or decrease fracture rates...
February 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29670391/determining-30-day-readmission-risk-for-heart-failure-patients-the-readmission-after-heart-failure-scale
#14
Ronald S Chamberlain, Jaswinder Sond, Krishnaraj Mahendraraj, Christine Sm Lau, Brianna L Siracuse
Background: Chronic heart failure (CHF), which affects >5 million Americans, accounts for >1 million hospitalizations annually. As a part of the Hospital Readmission Reduction Program, the Affordable Care Act requires that the Centers for Medicare and Medicaid Services reduce payments to hospitals with excess readmissions. This study sought to develop a scale that reliably predicts readmission rates among patients with CHF. Methods: The State Inpatient Database (2006-2011) was utilized, and discharge data including demographic and clinical characteristics on 642,448 patients with CHF from California and New York (derivation cohort) and 365,359 patients with CHF from Florida and Washington (validation cohort) were extracted...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29665283/accelerated-executive-functions-decline-and-gray-matter-structural-changes-in-middle-aged-type-1-diabetes-patients-with-proliferative-retinopathy
#15
Eelco van Duinkerken, Martijn D Steenwijk, Martin Klein, Frederik Barkhof, Daniel C Mograbi, Michaela Diamant, Frank J Snoek, Richard G Ijzerman
BACKGROUND: The aim of this study was to determine trajectories of cognitive and cortical changes over time in middle-aged patients with type 1 diabetes and proliferative retinopathy. METHODS: Twenty-five patients and 25 controls underwent neuropsychological assessment and neuroimaging twice in 3.56 ± 0.65 and 3.94 ± 0.91 years respectively (P = 0.098). Cognitive assessment included the domains of general cognitive ability, memory, information processing speed, executive functions, attention, motor and psychomotor speed...
April 17, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29664737/insulin-regulates-astrocyte-gliotransmission-and-modulates-behavior
#16
Weikang Cai, Chang Xue, Masaji Sakaguchi, Masahiro Konishi, Alireza Shirazian, Heather A Ferris, Mengyao Li, Ruichao Yu, Andre Kleinridders, Emmanuel N Pothos, C Ronald Kahn
Complications of diabetes affect tissues throughout body, including central nervous system. Epidemiological studies show that diabetic patients have increased risk of depression, anxiety, age-related cognitive decline and Alzheimer's disease. Mice lacking insulin receptor in brain or on hypothalamic neurons display an array of metabolic abnormalities, however, the role of insulin action on astrocytes and neurobehaviors remains less well-studied. Here, we demonstrate that astrocytes are a direct insulin target in the brain and that knockout of IR on astrocytes causes increased anxiety and depressive-like behaviors in mice...
April 17, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29664448/a-review-of-the-bidirectional-relationship-between-psychiatric-disorders-and-diabetes-mellitus
#17
Abdulrahman A Al-Atram
The prevalence of type 2 diabetes is rising worldwide, including Saudi Arabia. Among patients with diabetes, 30% suffer from mental disorders, such as depression, schizophrenia, delirium, and substance misuse (for example, tobacco smoking). Moreover, these disorders appear to share a bidirectional relationship with diabetes. For example, the incidence of diabetes has been shown to be 2-4 times greater in patients with schizophrenia than in normal individuals; also, there is a known association between depression and diabetes...
April 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/29663652/a-longitudinal-study-of-serum-insulin-like-growth-factor-i-igf-i-levels-over-six-years-in-a-large-cohort-of-children-and-adolescents-with-type-1-diabetes-mellitus-a-marker-reflecting-diabetic-retinopathy
#18
Daniel Öberg, Jenny Salemyr, Eva Örtqvist, Anders Juul, Peter Bang
OBJECTIVE: To evaluate longitudinal serum IGF-I in a large cohort of children and adolescents with type 1 diabetes in relation to HbA1c, age, diabetes duration, and BMI, its association to height and retinopathy, and in comparison with healthy subject references. RESEARCH DESIGN AND METHODS: A total of 2,683 serum IGF-I values were obtained from 806 children and adolescents with T1DM, from annual blood samples for up to 6 consecutive years. RESULTS: In a multiple regression analysis IGF-I values were negatively correlated to HbA1c and diabetes duration, and positively correlated to BMI (p<0...
April 16, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29661060/mental-work-demands-and-late-life-cognitive-impairment-results-from-the-shanghai-aging-study
#19
Xiaoniu Liang, Zhao Chen, Xinqi Dong, Qianhua Zhao, Qihao Guo, Li Zheng, Wei Deng, Jianfeng Luo, Ding Ding
OBJECTIVE: The aim of this study is to explore the association between mental work demands (MWDs) and late-life cognition among Chinese older adults. METHOD: Data were drawn from the baseline of the Shanghai Aging Study. RESULTS: Among 3,546 participants, the mean MWDs index of participants with dementia, mild cognitive impairment (MCI), and cognitive normal were 2.8 ( SD = 0.5), 2.8 ( SD = 0.5), and 2.9 ( SD = 0.4), respectively. Mini Mental State Examination (MMSE) scores in group with low MWDs level decreased more dramatically by increasing age than that in groups with middle and high MWDs level ( p < ...
April 1, 2018: Journal of Aging and Health
https://www.readbyqxmd.com/read/29660933/medical-comorbidity-in-alzheimer-s-disease-a-nested-case-control-study
#20
Jen-Hung Wang, Ya-Ju Wu, Boon Lead Tee, Raymond Y Lo
BACKGROUND: Little is known about the distribution of medical comorbidities in Alzheimer's disease (AD). OBJECTIVE: We aimed to describe the comorbidity pattern of AD in a nested case-control study. METHODS: Incident AD cases were identified by International Classification of Diseases codes in a random sample of 2 million individuals in Taiwan National Health Insurance program during 2001-2011. We further restricted cases to those treated with AD drugs of approved reimbursement...
April 11, 2018: Journal of Alzheimer's Disease: JAD
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