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Ziziphus spinosa

Chunmei Zhang, Jian Huang, Xingang Li
Chinese jujube (Ziziphus jujuba Mill.) is the most economically important member of the Rhamnaceae family and contains a high concentration of ascorbic acid (AsA). To explore the metabolic mechanism of AsA accumulation, we investigated the abundance of AsA in the fruit development stages, the leaf and flower of Z. jujuba cv Junzao, and the mature fruit of one type of wild jujube (Z. jujuba var. spinosa Hu, Yanchuan sour jujube). And the expression patterns of genes involved in AsA biosynthesis, degradation, and recycling were analyzed...
2016: Frontiers in Plant Science
Feng-xiang Zhang, Min Li, Li-rui Qiao, Zhi-hong Yao, Chang Li, Xiu-yu Shen, Yu Wang, Kate Yu, Xin-sheng Yao, Yi Dai
A strategy for rapid identification of target and non-target components from traditional Chinese medicines (TCMs) extracts were proposed by utilizing the UNIFI informatics platform for the computer-assisted UPLC/Qtof MS data analyses. Ziziphi Spinosae Semen (ZSS) contains various bioactive chemical ingredients, such as flavonoids, saponins, alkaloids and terpenes. Currently, there is no method that allows rapid and comprehensive identification of these multiple components. The rapid identification of chemical components in ZSS was successfully achieved with this strategy...
April 15, 2016: Journal of Pharmaceutical and Biomedical Analysis
Ke-xian Chen, Li-mei Zhao, Chang-jiu Ji, Ning-hua Tan
Five flavone C-glycosides were isolated from the methanol extract of the degrease seeds of Ziziphus jujuba var. spinosa though various column chromatography methods including silica gel, MPLC, and HPLC. The structures were elucidated as 6"-feruloyl- 6'''-vanillylspinosin(1), 6",6'"-diferuloylspinosin(2), spinosin(3), swertisin(4) and isoswertisin(5) based on the NMR and MS spectral data. 1 is a new compound.
April 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Xiaoxi Zhang, Zengwen Liu, Qi Yu, Nhu Trung Luc, Yuanhao Bing, Bochao Zhu, Wenxuan Wang
The impacts of petroleum contamination on the litter decomposition of shrub-grass land would directly influence nutrient cycling, and the stability and function of ecosystem. Ten common shrub and grass species from Yujiaping oil deposits were studied. Litters from these species were placed into litterbags and buried in petroleum-contaminated soil with 3 levels of contamination (slight, moderate and serious pollution with petroleum concentrations of 15, 30 and 45 g/kg, respectively). A decomposition experiment was then conducted in the lab to investigate the impacts of petroleum contamination on litter decomposition rates...
July 1, 2015: Journal of Environmental Sciences (China)
Yuan Yue, Shuangchan Wu, Zhike Li, Jian Li, Xiaofei Li, Jin Xiang, Hong Ding
Dietary polysaccharides provide various beneficial effects for our health. We investigated the protective effects of wild jujube (Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou) sarcocarp polysaccharides (WJPs) against experimental inflammatory bowel disease (IBD) by enabling enhanced intestinal barrier function. Colitis was induced in rats by the intrarectal administration of TNBS. We found that WJPs markedly ameliorated the colitis severity, including less weight loss, decreased disease activity index scores, and improved mucosal damage in colitis rats...
August 2015: Food & Function
Yanqing Zhang, Longdong Qiao, Mengyuan Song, Lijuan Wang, Junbo Xie, Hua Feng
BACKGROUND: Ziziphi Spinosae Semen (ZSS), the seed of Ziziphus jujuba var. spinosa (Bunge) Hu ex H. F. Chow., is a traditional herb for insomnia and anxiety in eastern Asia. However, few researches have been concerned with its effect on ameliorating memory and learning performance. OBJECTIVE: To investigate the constituents of ZSS water soluble extract and its ameliorating learning and memory in mice. MATERIALS AND METHODS: A new high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed and validated to determine the main constituents in the extract...
October 2014: Pharmacognosy Magazine
Yuan Yue, Shuangchan Wu, Huifang Zhang, Xuyan Zhang, Yunhui Niu, Xiaoqin Cao, Fuwei Huang, Hong Ding
The polysaccharides from Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou sarcocarp (PWJS) is evaluated for the chemical composition, antioxidant activity and hepatoprotective effect. The characteristics of PWJS were determined by FT-IR spectral and HPLC analysis. The antioxidant activity was investigated using in vitro systems. An in vivo study of PWJS against CCl4 induced liver injury was also conducted. HPLC analysis showed that PWJS is an acidic heteropolysaccharide, rich in glucose (38.59%), arabinose (23...
December 2014: Food and Chemical Toxicology
Min Li, Yu Wang, Bun Tsoi, Xiao-jie Jin, Rong-Rong He, Xiao-jun Yao, Yi Dai, Hiroshi Kurihara, Xin-Sheng Yao
A pair of diastereoisomers, the N-glycosylated derivatives of dioxindole-3-hydroxy-3-acetic acid 1-2, and their conjugates with flavonoids 3-8, was isolated from the seeds of Ziziphus jujuba var. spinosa. Their structures were elucidated by NMR spectroscopic analyses, and the absolute configurations were determined by circular dichroism method. Compounds 3-10 were evaluated for the antioxidant capacity, using the radical absorbance capacity (ORAC) assay.
December 2014: Fitoterapia
Naohiro Oshima, Kazumasa Zaima, Hiroyuki Kamakura, Akane Hamato, Yutaka Yamamoto, Dong Hyo Kang, Tsuguo Yokokura, Yukihiro Goda, Takashi Hakamatsuka, Takuro Maruyama
Jujube seed is a crude drug defined as the seed of Ziziphus jujuba Miller var. spinosa Hu ex H.F. Chou (Rhamnaceae) in the Japanese Pharmacopoeia (JP). Most of the jujube seed in the Japanese markets is imported from China, with the rest obtained from other Asian countries. Here we confirmed the botanical origins of jujube seeds from both China and Myanmar by a DNA sequencing analysis. We found that the botanical origins of the crude drugs from China and Myanmar were Z. jujuba and Z. mauritiana, respectively...
January 2015: Journal of Natural Medicines
Zhi Liu, Xu Zhao, Bing Liu, Ai-jing Liu, Huan Li, Xin Mao, Bo Wu, Kai-shun Bi, Ying Jia
Semen Ziziphi Spinosae (SZS) has been used as a hypnotic-sedative medicine for thousands of years. Recently, SZS has also shown notable neuroprotective activities via anti-oxidative and anti-inflammatory effects in dementia animals. Jujuboside A (JuA), isolated from SZS, has been proved to be a major hypnotic-sedative component of SZS. In the present study, we firstly evaluated the effects of intracerebroventricular (ICV) injection of JuA (0.02 and 0.2mg/kg) for five consecutive days on cognitive impairment induced by ICV injection of Aβ 1-42...
September 5, 2014: European Journal of Pharmacology
Jia-Rong Gao, Wen-Bo Ji, Hui Jiang, Jin-Feng Chen
OBJECTIVE: To observe the effects of extract from Ziziphus Spinosa Semen and Schisandrae Chinensis Fructus on the content of amino acid neurotransmitter in the hypothalamus of insomnia rats induced by P-Chlorophenylalanine (PCPA) and its mechanism. METHODS: The model of insomnia rats were established by PCPA intraperitoneal injection, after the modeling, all the therapeutic group were treated with corresponding drug for one week. The hypothalamus pathological changes of the rats were observed...
October 2013: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
Mei-Ying Xu, So Young Lee, Sam Sik Kang, Yeong Shik Kim
Jujuboside B (1) is one of the saponins isolated from the seeds of Zizyphus jujuba var. spinosa, which are used as a well-known traditional medicine for the treatment of insomnia and anxiety in East Asian countries. This is the first study to investigate the antitumor mechanism of 1 in vivo and in vitro. The results showed that 1 induced apoptosis and autophagy in AGS and HCT 116 human cancer cells and also effectively suppressed tumor growth in a nude mouse xenograft model bearing HCT 116 cells. The apoptosis-inducing effect of 1 was characterized by annexin V/propidium iodide staining, sub-G1 phase increase, and caspase-3 activation...
February 28, 2014: Journal of Natural Products
Won Il Kim, Bing Tian Zhao, Hai Yan Zhang, Je Hyun Lee, Jong Keun Son, Mi Hee Woo
Two rapid and simple HPLC methods with UV detector to determine three main compounds (magnoflorine, spinosin and 6'''-feruloyl spinosin) and evaporative light scattering detector (ELSD) to determine jujuboside A were developed for the chemical analyses of Zizyphi Semen. Magnoflorine, spinosin, and 6'''-feruloyl spinosin were separated with an YMC J'sphere ODS-H80 column (250 mm × 4.6 mm, 4 μm) by the gradient elution followed by the isocratic elution using methanol with 0.1 % formic acid and water with 0...
2014: Archives of Pharmacal Research
Bao Yang, Hongshun Yang, Feng Chen, Yanglin Hua, Yueming Jiang
Ziziphus jujuba Mill. var. spinosa (Z. jujuba) seeds have attracted much attention within the field of medicine due to their significant effects against disturbances of the central nervous system. Secondary metabolites composition is key to the influence of the pharmaceutical and commercial qualities of this plant. In this work, the phytochemical profile of Z. jujuba seeds was analysed by ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and gas chromatography-mass spectrometry (GC-MS)...
November 21, 2013: Analyst
Yu Wang, Bo Ding, Dan Luo, Liu-Yuan Chen, Yun-Long Hou, Yi Dai, Xin-Sheng Yao
Four new dammarane-type triterpene glycosides, named jujubosides I-IV (1-4), were isolated from Ziziphi Spinosae Semen, along with seven known saponins (5-11). The structures of new compounds were established on the basis of extensive spectroscopic analysis. All compounds were evaluated for the effects on neonatal rat cardiomyocyte injury induced by hydrogen peroxide in vitro.
October 2013: Fitoterapia
Sheng Guo, Jin-ao Duan, Dawei Qian, Hanqing Wang, Yuping Tang, Yefei Qian, Dawei Wu, Shulan Su, Erxin Shang
In this study, a rapid and sensitive analytical method was developed for the determination of 20 nucleobases, nucleosides and nucleotides in Ziziphus plants at trace levels by using hydrophilic interaction ultra-high performance liquid chromatography coupled with triple-quadrupole tandem mass spectrometry (HILIC-UHPLC-TQ-MS/MS) in multiple-reaction monitoring (MRM) mode. Under the optimized chromatographic conditions, good separation for 20 target compounds were obtained on a UHPLC Amide column with sub-2μm particles within 10min...
August 2, 2013: Journal of Chromatography. A
Cui-Ying Zhang, Jie Wang, Li-Li Guo, Hui-Ping Cheng, Han-Ming Cui, Ping Wu, Yu Dong, Shi-Jing Huang
OBJECTIVE: To establish an HPLC method of a characteristical chemical fingerprint analysis in combination with simultaneous determination of four bioactive components for species differentiation and quality assessment of Ziziphus jujuba var. spinosa. METHODS: The chromatographic separation was performed on an Agilent TC-C18 BDS (250 mm x 4.6 mm, 5 microm) column. The mobile phase consisted of acetonitrile and water in a linear gradient elution procedure. The evaporator tube temperature of ELSD was set at 110...
November 2012: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
Jie-Shu You, Min Peng, Jin-Li Shi, Hu-Zhan Zheng, Yong Liu, Bao-Sheng Zhao, Jian-You Guo
BACKGROUND: Compound Valeriana jatamansi Jones is a formula for treating anxiety-related diseases in the clinic, which is composed of Valeriana jatamansi Rhizoma et Radix, Ziziphi Spinosae Semen, Albiziae Cortex and Junci Medulla. The purpose of this study was to explore the anxiolytic properties of this compound in mice. METHODS: Male ICR mice were treated with compound Valerianae Jatamansi Jones (1.2 g/kg, 2.4 g/kg, 4.8 g/kg), saline, diazepam (2 mg/kg) orally for 10 days and then exposed to elevated maze-plus (EPM) and light-dark box (LDB)...
2012: BMC Complementary and Alternative Medicine
Jun-an Zhang, Bo Chen
OBJECTIVE: To establish a rapid and simple method for the determination of volatile constituents in Semen Ziziphi Spinosae. METHODS: The volatile constituents in Semen Ziziphi Spinosae were extracted by head space solid-phase microextraction (HS-SPME) and analysed by GC-MS. RESULTS: Powder of sample was pre-heated for 30 min at 90 degrees C, then headspace-extracted with 65 microm PDMS/DVB fiber for 50 min. After desorbed for 5 min at 250 degrees C, the separation was well completed on a Rxi -50 capillary column...
February 2012: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
Yan Ren, Pengyuan Wang, Caisheng Wu, Jinlan Zhang, Chunyan Niu
Ziziphi spinosae semen (ZSS) is a traditional Chinese medicine that has been widely used to treat insomnia and anxiety. Modern pharmacological studies have demonstrated that flavonoids are the main active compounds in ZSS. However, the metabolites and the metabolic pathways of flavonoids in ZSS have not been investigated thoroughly. In this study, a method based on high-performance liquid chromatography coupled with Fourier transform ion cyclotron resonance mass spectrometry (HPLC/FTICR-MS) was established to identify the metabolites of flavonoids after oral administration of extract of ZSS to rats or dogs, using parent mass list-triggered data-dependent multiple-stage mass analysis at a resolving power of 50,000 in the external calibration mode...
January 2013: Biomedical Chromatography: BMC
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