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Emmy Tuenter, Rizwan Ahmad, Kenn Foubert, Adnan Amin, Maria Orfanoudaki, Paul Cos, Louis Maes, Sandra Apers, Luc Pieters, Vassiliki Exarchou
Nine cyclopeptide alkaloids (1-9), of which five (compounds 2, 3, 5, 8, and 9) are described herein for the first time, were isolated from roots of Ziziphus oxyphylla by means of conventional separation methods as well as semipreparative HPLC with DAD and ESIMS detection and LC-DAD-SPE-NMR. Structure elucidation was done by spectroscopic means. Nummularine-R (1), a previously known constituent from this species, was isolated along with its new derivatives O-desmethylnummularine-R (2) and O-desmethylnummularine-R N-oxide (3)...
November 23, 2016: Journal of Natural Products
Fenjuan Shao, Qian Zhang, Hongwei Liu, Shanfa Lu, Deyou Qiu
MicroRNAs (miRNAs) play an important role in responding to biotic and abiotic stresses in plants. Jujube witches'-broom a phytoplasma disease of Ziziphus jujuba is prevalent in China and is a serious problem to the industry. However, the molecular mechanism of the disease is poorly understood. In this study, genome-wide identification and analysis of microRNAs in response to witches'-broom was performed. A total of 85 conserved miRNA unique sequences belonging to 32 miRNA families and 24 novel miRNA unique sequences, including their complementary miRNA* strands were identified from small RNA libraries derived from a uninfected and witches'-broom infected Z...
2016: PloS One
Qiang Fu, Yu Ma, Jiang Chen, Hai-Mei Yuan, Yu-Zhong Zheng
Two new C-glucosyl flavonoids 6''-O-feruloylspinosin and 6''-O-feruloyl-6'''-p-hydroxybenzoylspinosin, together with five known compounds, were isolated from the seeds of Ziziphus jujube (Rhamnaceae family). Their structures were elucidated on the basis of chemical and spectroscopic evidences. Compounds 1-7 showed moderate inhibitory effects against COX-1 and COX-2 enzymes.
September 21, 2016: Journal of Asian Natural Products Research
Soumya Soman, J G Ray
Biological approach to synthesis of metal nanoparticles using aqueous leaf extract is a highly relevant and recent theme in nanotechnological research. Phytosynthesized AgNPs have better inhibitory and antimicrobial effects compared to aqueous leaf extract and silver nitrate. In the present investigation crystalline silver nanoparticles (AgNPs) with size of 10nm have been successfully synthesized using aqueous leaf extract (AQLE) of Ziziphus oenoplia (L.) Mill., which act as both reducing as well as capping agent...
October 2016: Journal of Photochemistry and Photobiology. B, Biology
M Elaloui, H Ghazghazi, A Ennajah, S Manaa, W Guezmir, N B Karray, A Laamouri
The aim of this work was to evaluate some secondary metabolites, antioxidant activity of methanolic leaf extracts of five Ziziphus spina-christi provenances (INRGREF, Tozeur, Degueche, Nafta and Kebelli) and their allelopathic effects on Trigonella foenum-graecum and Lens culinaris. Leaves were collected during 2013 and 2014. Total phenols, flavonoids, tannins and antioxidant activity were evaluated using the Folin ciocalteux, Aluminum trichloride, vanillin and scavenging activity on 22-diphenyl-1-picrylhydrazyl (DPPH) radical methods, respectively...
September 12, 2016: Natural Product Research
Kyo Bin Kang, Jung Wha Kim, Won Keun Oh, Jinwoong Kim, Sang Hyun Sung
Ziziphus jujuba, a plant in the family Rhamnaceae, is used in several Asian countries as a food and traditional medicine. Fifteen new ceanothane-type (1-15) and three new lupane-type triterpenoids (16-18) were isolated from the roots of Z. jujuba, as well as 12 previously known triterpenoids (19-30). Their structures were elucidated by 1D and 2D NMR spectroscopic and HR mass spectrometric data analysis. Compounds 12 and 13 were found to possess a rare E-ring γ-lactone structure, and 14 was assigned as the first 2,28-dinorlupane derivative isolated as a natural product...
September 23, 2016: Journal of Natural Products
Soumyajit Biswas, Rupa Shaw, Sanjay Bala, Asis Mazumdar
ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal Plant resources of forest origin are extensively used in India for various systems of medicine like Ayurveda, Unani, Homeopathy, Allopathy, Siddha and Ethnic etc. The tribal communities around the Kakrajhore forest in West Medinipur district of West Bengal have their own traditional knowledge based system of curing many diseases using the forest based plant resources similar to ayurveda. The forest comprises of one of the unique treasure and rich source of diversified ethno-botanical wealth and therefore extensive studies is required for proper documentation including ethnomedicinal knowledge of local tribes...
August 30, 2016: Journal of Ethnopharmacology
Chaoqun Xu, Jiao Gao, Zengfeng Du, Dengke Li, Zhe Wang, Yingyue Li, Xiaoming Pang
Ziziphus is a genus of spiny shrubs and small trees in the Rhamnaceae family. This group has a controversial taxonomy, with more than 200 species described, including Chinese jujube (Ziziphus jujuba Mill. var. jujuba) and Indian jujube (Z. mauritiana), as well as several other important cultivated fruit crops. Using 24 SSR markers distributed across the Chinese jujube genome, 962 jujube accessions from the two largest germplasm repositories were genotyped with the aim of analyzing the genetic diversity and structure and constructing a core collection that retain high genetic diversity...
2016: Scientific Reports
Ghazaleh Heydarirad, Rasool Choopani, Pasalar Mehdi, Jamileh Mahdavi Jafari
BACKGROUND: Mucilage compounds are pharmaceutically important polysaccharides that have an extensive range of applications, including binding agents, thickeners, water retention agents, emulsion stabilizers, suspending agents, disintegrates, film formers, and gelling agents. A historical approach to medical science written by Iranian scholars could help in identifying excellent ideas and provide valuable information in this field for proper application. The aim of the current study was to introduce some mucilage uses derived from traditional Persian medicine (TPM)...
May 2016: Iranian Journal of Medical Sciences
C M Mnisi, V Mlambo
This study was designed to evaluate the chemical composition, buffer N solubility, in vitro ruminal N degradation and in vitro ruminal biological activity of condensed tannins in Acacia erioloba, Acacia nilotica and Ziziphus mucronata leaves harvested from two sites (Masuthle communal grazing land and Molelwane private farm). Leaves were harvested, dried at 60 °C and milled. The highest crude protein (CP) content was found in leaves of Z. mucronata (177.7 g/kg DM). Leaves harvested from Masuthle had higher (p < 0...
July 21, 2016: Journal of Animal Physiology and Animal Nutrition
Arifa Mehreen, Muzzamil Waheed, Iram Liaqat, Najma Arshad
The in vitro antibacterial activities of 29 traditional medicinal plants used in respiratory ailments were assessed on multidrug resistant Gram-positive and Gram-negative bacteria isolated from the sore throat patients and two reference strains. The methanolic, n-hexane, and aqueous extracts were screened by the agar well diffusion assay. Bioactive fractions of effective extracts were identified on TLC coupled with bioautography, while their toxicity was determined using haemolytic assay against human erythrocytes...
2016: BioMed Research International
Jiang-Tao Zhang, San-An Wu
A new mealybug, Crisicoccus ziziphus sp. nov. (Hemiptera: Coccomorpha: Pseudococcidae), collected on the leaves and twigs of Ziziphus jujuba (Rhamnaceae), is described from China. All the female developmental stages (adult, third-instar, second-instar and first-instar nymphs) are described and illustrated. Keys are provided to separate the female instars and to identify adult females of Crisicoccus species from China.
2016: Zootaxa
Somaye Alvani, Esmat Mahdikhani-Moghadam, Hamid Rouhani, Abbas Mohammadi, Gerrit Karssen
In order to identify plant-parasitic nematodes (family Tylenchidae Örley 1880) associated with Ziziphus zizyphus in Iran, 360 soil and root samples were collected from South Khorasan province during 2012-2014. Herein, a new species of Basiria and several known members of the family Tylenchidae are reported. B. birjandiensis n. sp. is characterized by short body length (584-748 µm [660.6±72.3]), lip region with flat apex, stylet 11-12 µm (11.3±0.5), excretory pore position varying from isthmus level to the middle of the basal bulb (78-91 µm from the anterior end of the body), post-vulval uterine sac 8-14 µm (10...
2016: Zootaxa
Lan-Song Li, Yu-Ping Meng, Qiu-Fen Cao, Yong-Zhen Yang, Fan Wang, Hu-Sheng Jia, Shu-Biao Wu, Xu-Guang Liu
Metallothioneins (MTs) are a family of low molecular weight, cysteine-rich, metal-binding proteins that are able to make cells to uptake heavy metals from the environment. Molecular and functional characterization of this gene family improves understanding of the mechanisms underlying heavy metal tolerance in higher organisms. In this study, a cDNA clone, encoding 74-a.a. metallothionein type 1 protein (ZjMT), was isolated from the cDNA library of Ziziphus jujuba. At the N- and C-terminals of the deduced amino acid sequence of ZjMT, six cysteine residues were arranged in a CXCXXXCXCXXXCXC and CXCXXXCXCXXCXC structure, respectively, indicating that ZjMT is a type 1 MT...
June 2016: Biochemistry. Biokhimii︠a︡
Dandan Han, Changrong Wan, Fenghua Liu, Xiaolong Xu, Linshu Jiang, Jianqin Xu
Jujuboside A is a kind of the saponins isolated from the seeds of Ziziphus jujuba, which possesses multiple biological effects, such as antianxiety, antioxidant, and anti-inflammatory effects; however, its mediatory effect on isoproterenol-stimulated cardiomyocytes has not been investigated yet. In this study, we tried to detect the protective effect and potential mechanism of JUA on ISO-induced cardiomyocytes injury. H9C2 cells were treated with ISO to induce cell damage. Cells were pretreated with JUA to investigate the effects on the cell viability, morphological changes, light chain 3 conversion, and the activation of PI3K/Akt/mTOR signaling pathway...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Lu Bai, Hai Zhang, Qingchao Liu, Yong Zhao, Xueqin Cui, Sen Guo, Li Zhang, Chi-Tang Ho, Naisheng Bai
The fruit of Ziziphus jujuba Mill., also called hongzao in Chinese, has a long history of cultivation in China. From the fruit of Z. jujuba, twenty-seven known compounds were isolated and identified as the main constituents of these fruits. They were 3-O-(trans-p-coumaroyl)-alphitolic acid (1), 3-O-(cis-p-coumaroyl)-alphitolic acid (2), 3β-O-(trans-p-coumaroyl)-maslinic acid (3), pomonic acid (4), 2-oxo-pomolic acid (5), benthamic acid (6), terminic acid (7), oleanic acid (8), betulinic acid (9), quercetin 3-O-rutinoside (10), quercetin 3-O-robinobioside (11), apigenin (12), traumatic acid (13), (Z)-4-oxotetradec-5-enoic acid (14), 7(E)-9-keto-hexadec-7-enoic acid (15), 9(E)-11-oxo-octadecenoic acid (9CI) (16), and magnoflorine (27), etc...
June 15, 2016: Food & Function
Mohammad Reza Abedini, Nafiseh Erfanian, Habibollah Nazem, Sara Jamali, Reyhane Hoshyar
OBJECTIVE: Ziziphus Jujube (Jujube) plant has exhibited numerous medicinal and pharmacological properties including antioxidant and anti-inflammatory effects. This study was carried out to investigate its anti-cancer and pro-apoptotic abilities in human cervical and breast cancer cells in vitro. MATERIALS AND METHODS: The cervical OV2008 and breast MCF-7 cancer cells were incubated with different concentrations of Jujube aqueous extraction (0-3 mg/ml) for various times (0-72 h)...
March 2016: Avicenna Journal of Phytomedicine
Jasdeep Chatrath Padaria, Radha Yadav, Avijit Tarafdar, Showkat Ahmad Lone, Kanika Kumar, Palaiyur Nanjappan Sivalingam
Drought is a calamitous abiotic stress hampering agricultural productivity all over the world and its severity is likely to increase further. Abscisic acid-stress-ripening proteins (ASR), are a group of small hydrophilic proteins which are induced by abscisic acid, stress and ripening in many plants. In the present study, ZnAsr 1 gene was fully characterized for the first time from Ziziphus nummularia, which is one of the most low water forbearing plant. Full length ZnAsr 1 gene was characterised and in silico analysis of ZnASR1 protein was done for predicting its phylogeny and physiochemical properties...
August 2016: Molecular Biology Reports
Qiuyue Ma, Shuxian Li, Changwei Bi, Zhaodong Hao, Congrui Sun, Ning Ye
Ziziphus jujuba is an important woody plant with high economic and medicinal value. Here, we analyzed and characterized the complete chloroplast (cp) genome of Z. jujuba, the first member of the Rhamnaceae family for which the chloroplast genome sequence has been reported. We also built a web browser for navigating the cp genome of Z. jujuba ( ). Sequence analysis showed that this cp genome is 161,466 bp long and has a typical quadripartite structure of large (LSC, 89,120 bp) and small (SSC, 19,348 bp) single-copy regions separated by a pair of inverted repeats (IRs, 26,499 bp)...
May 20, 2016: Current Genetics
Candy T W Lam, Amy G W Gong, Kelly Y C Lam, Laura M Zhang, Jian-Ping Chen, Tina T X Dong, Huang-Quan Lin, Karl W K Tsim
ETHNOPHARMACOLOGICAL RELEVANCE: The fruit of Ziziphus jujuba (Mill.), known as Jujuba Fructus (JF) or jujube, is a well-known Traditional Chinese Medicine (TCM) for blood nourishment and sedation effect. Apart from prescribing as single herb alone, JF is very often being included in multi-herbal decoctions to prolong, enhance and harmonize pharmaceutical effects of decoctions while at the same time reducing toxicity. Here, we aimed to compare the protective and differentiating activities of three chemically standardized jujube-containing decoctions, including Guizhi Tang (GZT), Neibu Dangguijianzhong Tang (NDT) and ZaoTang (ZOT) in cultured PC12 cells...
July 21, 2016: Journal of Ethnopharmacology
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