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https://www.readbyqxmd.com/read/27899337/furfural-and-glucose-can-enhance-conversion-of-xylose-to-xylitol-by-candida-magnoliae-tistr-5663
#1
Siwaporn Wannawilai, Wen-Chien Lee, Yusuf Chisti, Sarote Sirisansaneeyakul
Xylitol production from xylose by the yeast Candida magnoliae TISTR 5663 was enhanced by supplementing the fermentation medium with furfural (300mg/L) and glucose (3g/L with an initial mass ratio of glucose to xylose of 1:10) together under oxygen limiting conditions. In the presence of furfural and glucose, the final concentration of xylitol was unaffected relative to control cultures but the xylitol yield on xylose increased by about 5%. Supplementation of the culture medium with glucose alone at an initial concentration of 3g/L, stimulated the volumetric and specific rates of xylose consumption and the rate of xylitol production from xylose...
November 26, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/27886147/emerging-phytochemicals-for-the-prevention-and-treatment-of-head-and-neck-cancer
#2
REVIEW
Santosh K Katiyar
Despite the development of more advanced medical therapies, cancer management remains a problem. Head and neck squamous cell carcinoma (HNSCC) is a particularly challenging malignancy and requires more effective treatment strategies and a reduction in the debilitating morbidities associated with the therapies. Phytochemicals have long been used in ancient systems of medicine, and non-toxic phytochemicals are being considered as new options for the effective management of cancer. Here, we discuss the growth inhibitory and anti-cell migratory actions of proanthocyanidins from grape seeds (GSPs), polyphenols in green tea and honokiol, derived from the Magnolia species...
November 24, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27884427/sample-injection-strategy-to-increase-throughput-in-counter-current-chromatography-case-study-of-honokiol-purification
#3
Aihua Peng, Peter Hewitson, Haoyu Ye, Liansuo Zu, Ian Garrard, Ian Sutherland, Lijuan Chen, Svetlana Ignatova
Counter-current chromatography (CCC) has been widely used as a preparative separation method to purify natural products from plant extracts and fermentation broths. Traditionally, throughput optimization in CCC has focused on sample concentration and sample volume. In this paper sample injection was considered as consisting of three variables: injection flow rate, post-injection flow rate and sample solvent. The effects of these parameters were studied using a honokiol purification from a Magnolia officinalis bark extract as a case study aiming to achieve the highest throughput/yield ratio for greater than 99% purity of this potential anti-cancer drug obtained for submission to the Chinese FDA...
October 17, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27870096/allergic-contact-dermatitis-of-the-face-caused-by-magnolia-officinalis-bark-extract
#4
Trine D Nilausen, Jeanne D Johansen, Jacob P Thyssen
No abstract text is available yet for this article.
December 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27849557/honokiol-decreases-lung-cancer-metastasis-through-inhibition-of-the-stat3-signaling-pathway
#5
Jing Pan, Yongik Lee, Qi Zhang, Donghai Xiong, Wan C Tina, Yian Wang, Ming You
Lung cancer is the leading cause of cancer death in the United States. Metastasis to lymph nodes (LN) and distal organs, especially brain, leads to severe complications and death. Preventing lung cancer development and metastases is important strategy to reduce lung cancer mortality. Honokiol (HNK), a natural compound presents in extracts of magnolia bark, has a favorable bioavailability profile and recently has been shown to readily cross the blood-brain barrier (BBB). In the current study, we evaluated the anti-metastatic effects of HNK in both the LN and brain mouse models of lung tumor metastasis...
November 14, 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27774504/data-analyses-of-honokiol-induced-autophagy-of-human-glioma-cells-in-vitro-and-in-vivo
#6
Gong-Jhe Wu, Chien-Ju Lin, Yung-Wei Lin, Ruei-Ming Chen
This article contains raw and processed data related to a research, "Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway" (C.J. Lin, T.L. Chen, Y.Y. Tseng, G.J. Wu, M.H. Hsieh, Y.W. Lin, R.M. Chen, 2016) [1]. Data were obtained by immunoblotting analyses of light chain 3 (LC3)-II, beclin-1, Akt, and mTOR in human glioma U87 MG cells and mouse glioma tissues treated with honokiol, an active constituent extracted from the bark of Magnolia officinalis, "Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration" (P...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27769903/pre-existing-risk-factors-for-in-hospital-death-among-older-patients-could-be-used-to-initiate-end-of-life-discussions-rather-than-rapid-response-system-calls-a-case-control-study
#7
Magnolia Cardona-Morrell, Amanda Chapman, Robin M Turner, Ebony Lewis, Blanca Gallego-Luxan, Michael Parr, Ken Hillman
AIM: To investigate associations between clinical parameters - beyond the evident physiological deterioration and limitations of medical treatment - with in-hospital death for patients receiving Rapid Response System (RRS) attendances. METHODS: Retrospective case-control analysis of clinical parameters for 328 patients aged 60 years and above at their last RRS call during admission to a single teaching hospital in the 2012-2013 calendar years. Generalised estimating equation modelling was used to compare the deceased with a randomly selected sample of those who had RRS calls and survived admission (controls), matched by age group, sex, and hospital ward...
December 2016: Resuscitation
https://www.readbyqxmd.com/read/27765378/a-systematic-review-of-effectiveness-of-decision-aids-to-assist-older-patients-at-the-end-of-life
#8
Magnolia Cardona-Morrell, Gustavo Benfatti-Olivato, Jesse Jansen, Robin M Turner, Diana Fajardo-Pulido, Ken Hillman
OBJECTIVE: To describe the range of decision aids (DAs) available to enable informed choice for older patients at the end of life and assess their effectiveness or acceptability. METHODS: Search strategy covered PubMed, Scopus, Ovid MEDLINE, EMBASE, EBM Reviews, CINAHL and PsycInfo between 1995 and 2015. The quality criteria framework endorsed by the International Patient Decision Aids Standards (IPDAS) was used to assess usefulness. RESULTS: Seventeen DA interventions for patients, their surrogates or health professionals were included...
October 11, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/27743878/the-coordination-of-allocation-logistics-of-kidney-organ-allocation-to-highly-sensitized-patients
#9
John Lunz, Lisa Hinsdale, Casey King, Robin Pastush, Magnolia Buenvenida, Michael Harmon
Since implementation, the new UNOS OPTN kidney allocation system (KAS) has drastically expanded the pool of available kidneys to candidates that may have previously waited extended periods for an organ offer. This is particularly true for highly sensitized patients. The changes to the KAS have had ramifications throughout the transplant process, including for organ procurement organizations (OPO) and local transplant hospital call centers. Here, we will examine the impact of the new KAS on the organ donation process and highlight the necessary interactions between the OPO and transplant centers to best match donor kidneys and highly sensitized recipients...
October 12, 2016: Human Immunology
https://www.readbyqxmd.com/read/27723087/strand-specific-transcriptome-sequencing-using-smart-technology
#10
Magnolia Bostick, Nathalie Bolduc, Alisa Lehman, Andrew Farmer
Next-generation sequencing is empowering a deeper understanding of biology by enabling RNA expression analysis over the entire transcriptome with high sensitivity and a wide dynamic range. One powerful application within this field is stranded RNA sequencing (RNA-seq), which is necessary to distinguish overlapping genes and to conduct comprehensive annotation and quantification of long non-coding RNAs. Commonly used methods for generating strand-specific RNA-seq libraries are often complicated by protocols that require several rounds of enzymatic treatments and clean-up steps, making them time-intensive, insensitive, and unsuitable for processing several samples simultaneously...
October 10, 2016: Current Protocols in Molecular Biology
https://www.readbyqxmd.com/read/27723086/transcriptome-analysis-at-the-single-cell-level-using-smart-technology
#11
Rachel N Fish, Magnolia Bostick, Alisa Lehman, Andrew Farmer
RNA sequencing (RNA-seq) is a powerful method for analyzing cell state, with minimal bias, and has broad applications within the biological sciences. However, transcriptome analysis of seemingly homogenous cell populations may in fact overlook significant heterogeneity that can be uncovered at the single-cell level. The ultra-low amount of RNA contained in a single cell requires extraordinarily sensitive and reproducible transcriptome analysis methods. As next-generation sequencing (NGS) technologies mature, transcriptome profiling by RNA-seq is increasingly being used to decipher the molecular signature of individual cells...
October 10, 2016: Current Protocols in Molecular Biology
https://www.readbyqxmd.com/read/27721050/magnolia-officinalis-hou-po-bark-extract-stimulates-the-nrf2-pathway-in-hepatocytes-and-protects-against-oxidative-stress
#12
Arun Rajgopal, Stephen R Missler, Jeffery D Scholten
ETHNOPHARMACOLOGICAL RELEVANCE: The highly aromatic bark of Magnolia officinalis Rehder & EH Wilson, (magnolia bark) has been widely used in traditional Chinese medicine where it is known as Hou Po. Historically the bark of the tree has been used for treating variety of disorders the most common use of magnolia bark in traditional prescription has been to treat stress and anxiety disorders. Till date it is not clear regarding the fundamental cellular pathway it modulates. NRF2 signaling has emerged as the central pathway that protects cells from variety of stressors this led us to hypothesize that basis for magnolia bark's effects could be via activating NRF2 pathway...
October 6, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27699065/appetite-suppression-and-antiobesity-effect-of-a-botanical-composition-composed-of-morus-alba-yerba-mate-and-magnolia-officinalis
#13
Mesfin Yimam, Ping Jiao, Mei Hong, Lidia Brownell, Young-Chul Lee, Eu-Jin Hyun, Hyun-Jin Kim, Tae-Woo Kim, Jeong-Bum Nam, Mi-Ran Kim, Qi Jia
Background. Obesity and its comorbidities continue to challenge the world at an alarming rate. Although the long term solution lies on lifestyle changes in the form of dieting and exercising, drug, medical food, or dietary supplement interventions are required for those who are already obese. Here we describe a standardized blend composed of extracts from three medicinal plants: Morus alba, Yerba mate, and Magnolia officinalis for appetite suppression and metabolic disorders management. Method. Extracts were standardized to yield a composition designated as UP601...
2016: Journal of Obesity
https://www.readbyqxmd.com/read/27671820/honokiol-an-active-compound-of-magnolia-plant-inhibits-growth-and-progression-of-cancers-of-different-organs
#14
Ram Prasad, Santosh K Katiyar
Honokiol (C18H18O2) is a biphenolic natural product isolated from the bark and leaves of Magnolia plant spp. During the last decade or more, honokiol has been extensively studied for its beneficial effect against several diseases. Investigations have demonstrated that honokiol possesses anti-carcinogenic, anti-inflammatory, anti-oxidative, anti-angiogenic as well as inhibitory effect on malignant transformation of papillomas to carcinomas in vitro and in vivo animal models without any appreciable toxicity. Honokiol affects multiple signaling pathways, molecular and cellular targets including nuclear factor-κB (NF-κB), STAT3, epidermal growth factor receptor (EGFR), cell survival signaling, cell cycle, cyclooxygenase and other inflammatory mediators, etc...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27669240/extracts-of-magnolia-species-induced-prevention-of-diabetic-complications-a-brief-review
#15
REVIEW
Xuezhong Zhao, Fengsheng Li, Wanqing Sun, Ling Gao, Ki Soo Kim, Kyoung Tae Kim, Lu Cai, Zhiguo Zhang, Yang Zheng
Diabetic complications are the major cause of mortality for the patients with diabetes. Oxidative stress and inflammation have been recognized as important contributors for the development of many diabetic complications, such as diabetic nephropathy, hepatopathy, cardiomyopathy, and other cardiovascular diseases. Several studies have established the anti-inflammatory and oxidative roles of bioactive constituents in Magnolia bark, which has been widely used in the traditional herbal medicines in Chinese society...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27633759/honokiol-inhibits-migration-of-renal-cell-carcinoma-through-activation-of-rhoa-rock-mlc-signaling-pathway
#16
Shujie Cheng, Victor Castillo, Matt Welty, Isaac Eliaz, Daniel Sliva
Honokiol, a biologically active compound isolated from Magnolia bark, has been shown to possess promising anticancer effect through induction of apoptosis. However, there is a relative lack of information regarding its anti‑metastatic activity. Renal cell carcinoma (RCC) is the most common malignancy of the adult kidney and is known for high risk of metastasis. Clinically, therapeutic methods for metastatic RCC cases are limited and efforts to exploit new treatments are still ongoing. The results of our current investigation first revealed that honokiol suppressed the proliferation of different human RCCs without affecting cell viability...
August 19, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27627917/magnolia-officinalis-l-fortified-gum-improves-resistance-of-oral-epithelial-cells-against-inflammation
#17
Jessica Walker, Julia Maria Imboeck, Joel Michael Walker, Amarnath Maitra, Hady Haririan, Xiaohui Rausch-Fan, Michael Dodds, Taichi Inui, Veronika Somoza
Inflammatory diseases of the periodontal tissues are known health problems worldwide. Therefore, anti-inflammatory active compounds are used in oral care products to reduce long-term inflammation. In addition to inducing inflammation, pathogen attack leads to an increased production of reactive oxygen species (ROS), which may lead to oxidative damage of macromolecules. Magnolia officinalis L. bark extract (MBE) has been shown to possess antioxidant and anti-inflammatory potential in vitro. In the present study, the influence of MBE-fortified chewing gum on the resistance against lipopolysaccharide (LPS)-induced inflammation and oxidative stress of oral epithelial cells was investigated in a four-armed parallel designed human intervention trial with 40 healthy volunteers...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27609457/honokiol-suppresses-pancreatic-tumor-growth-metastasis-and-desmoplasia-by-interfering-with-tumor-stromal-cross-talk
#18
Courey Averett, Arun Bhardwaj, Sumit Arora, Sanjeev K Srivastava, Mohammad Aslam Khan, Aamir Ahmad, Seema Singh, James E Carter, Moh'd Khushman, Ajay P Singh
The poor clinical outcome of pancreatic cancer (PC) is largely attributed to its aggressive nature and refractoriness to currently available therapeutic modalities. We previously reported antitumor efficacy of honokiol (HNK), a phytochemical isolated from various parts of Magnolia plant, against PC cells in short-term in vitro growth assays. Here, we report that HNK reduces plating efficiency and anchorage-independent growth of PC cells and suppresses their migration and invasiveness. Furthermore, significant inhibition of pancreatic tumor growth by HNK is observed in orthotopic mouse model along with complete-blockage of distant metastases...
September 8, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27593221/honokiol-inhibits-emt-mediated-motility-and-migration-of-human-non-small-cell-lung-cancer-cells-in-vitro-by-targeting-c-flip
#19
Xiao-Qin Lv, Xin-Ran Qiao, Ling Su, Shu-Zhen Chen
AIM: Honokiol (HNK) is a natural compound isolated from the magnolia plant with numerous pharmacological activities, including inhibiting epithelial-mesenchymal transition (EMT), which has been proposed as an attractive target for anti-tumor drugs to prevent tumor migration. In this study we investigated the effects of HNK on EMT in human NSCLC cells in vitro and the related signaling mechanisms. METHODS: TNF-α (25 ng/mL) in combination with TGF-β1 (5 ng/mL) was used to stimulate EMT of human NSCLC A549 and H460 cells...
December 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27547207/patterns-of-ros-accumulation-in-the-stigmas-of-angiosperms-and-visions-into-their-multi-functionality-in-plant-reproduction
#20
Adoración Zafra, Juan D Rejón, Simon J Hiscock, Juan de Dios Alché
Accumulation of reactive oxygen species (ROS) in the stigma of several plant species has been investigated. Four developmental stages (unopened flower buds, recently opened flowers, dehiscent anthers, and flowers after fertilization) were analyzed by confocal laser scanning microscopy using the ROS-specific probe DCFH2-DA. In all plants scrutinized, the presence of ROS in the stigmas was detected at higher levels during those developmental phases considered "receptive" to pollen interaction. In addition, these molecules were also present at early (unopened flower) or later (post-fertilization) stages, by following differential patterns depending on the different species...
2016: Frontiers in Plant Science
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