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https://www.readbyqxmd.com/read/28925032/susceptibility-of-malassezia-pachydermatis-to-aminoglycosides
#1
Freddy Alejandro Silva, Magnolia Conde-Felipe, Inmaculada Rosario, Otilia Ferrer, Fernando Real, Soraya Déniz, Félix Acosta, Daniel Padilla, Begoña Acosta-Hernández
Previous studies have evaluated the action of gentamicin against Malassezia pachydermatis. The aim of this study was to evaluate in vitro susceptibility of M. pachydermatis to the aminoglycosides- gentamicin, tobramycin, netilmicin and framycetin. The minimum inhibitory concentration (MIC) of gentamicin was determined following methods M27-A3 microdilution and Etest(®) . The Etest(®) was used to determine the minimum inhibitory concentration (MIC) of the tobramycin and netilmicin. The Kirby-Bauer test was used to determine the antibiotic susceptibility to the framycetin...
September 19, 2017: Mycoses
https://www.readbyqxmd.com/read/28919305/magnolol-protects-pancreatic-%C3%AE-cells-against-methylglyoxal-induced-cellular-dysfunction
#2
Kwang Sik Suh, Suk Chon, Woon-Won Jung, Eun Mi Choi
Chronic hyperglycemia aggravates insulin resistance, in part due to increased formation of advanced glycation end-products (AGEs). Methylglyoxal (MG), a major precursor of AGEs, accumulates abnormally in various tissues and organs and participates in oxidative damage. We investigated the insulinotropic benefits of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, in pancreatic β-cells exposed to MG in vitro. When exposed to cytotoxic levels of MG for 48 h, RIN-m5F β-cells exhibited a significant loss of viability and impaired insulin secretion, whereas pretreatment with magnolol protected against MG-induced cell death and decreased insulin secretion...
September 15, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28874849/inhibitory-effect-of-obovatol-from-magnolia-obovata-on-the-salmonella-type-iii-secretion-system
#3
Won-Sik Choi, Tae Hun Lee, Se Jin Son, Tae Gyu Kim, Byoung-Mog Kwon, Hyeong-U Son, Sung Uk Kim, Sang-Han Lee
In many pathogenic Gram-negative bacteria, such as Salmonella, Escherichia coli, Yersinia and Chlamydia spp., which cause diseases in humans, the type III secretion system (TTSS) is an important virulence factor that translocates effector proteins into the cytosol of host cells. Thus, the TTSS is a good target for antibacterial agents. Here we used a hemolysis assay to search for TTSS inhibitors and found that a compound from Magnolia obovata called obovatol blocks the TTSS of Salmonella. Obovatol showed potent inhibitory activity (IC50=19...
September 6, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28867711/four-new-lignans-and-il-2-inhibitors-from-magnoliae-flos
#4
Thi Tuyet Mai Nguyen, Hyun-Su Lee, Thi Thu Nguyen, Thi Quynh Mai Ngo, Chang-Duk Jun, Byung Sun Min, Jeong Ah Kim
Four new lignans, a furofuran lignan medioresinol B (10) and three tetrahydrofuran lignans kobusinol C (16), 7'-methoxy magnostellin A (21), and mangnostellin D (23), along with 19 known lignans, were isolated from the flower buds of Magnolia biondii PAMP. The structures of the isolates were elucidated using spectroscopic analysis, mainly one- and two-dimensional NMR, high resolution-MS, and circular dichroism techniques as well as Mosher's esterification method. The anti-allergic effects of the isolated compounds were evaluated by analyzing the inhibition of interleukin-2 (IL-2) expression in Jurkat T-cells...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28864109/a-modification-on-the-vector-cosine-algorithm-of-similarity-analysis-for-improved-discriminative-capacity-and-its-application-to-the-quality-control-of-magnoliae-flos
#5
Guang Yang, Xin Zhao, Guorong Fan
Chromatographic fingerprint analysis has been widely used in quality control of herbal medicines, and Similarity Analysis (SA) as a well-established method has been applied in the quality control practice as well as publications related to the study of herbal medicines and preparations. However, in some cases the results of SA do not fit well with those of other chemometric approaches and quantitative analysis, and the problem remains unsolved. In this study, a modified SA algorithm has been proposed, with its advantages discussed in theory...
August 16, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28857279/self-perceived-mouthfeel-and-physico-chemical-surface-effects-after-chewing-gums-containing-sorbitol-and-magnolia-bark-extract
#6
Stefan W Wessel, Henny C van der Mei, Anje M Slomp, Betsy van de Belt-Gritter, Michael W J Dodds, Henk J Busscher
The European Food Safety Authority recognizes the contribution of sugar-free chewing gum to oral health through increased salivation, clearance of food debris, and neutralization of biofilm pH. Magnolia bark extract is a gum additive shown to reduce the prevalence of bad-breath bacteria but its effects on self-perceived mouthfeel are unknown. This paper aims to relate the effects of sorbitol-containing chewing gum, with and without Magnolia bark extract, on tooth-surface hydrophobicity and salivary-film composition with self-perceived mouthfeel...
August 31, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28854218/honokiol-induces-superoxide-production-by-targeting-mitochondrial-respiratory-chain-complex-i-in-candida-albicans
#7
Lingmei Sun, Kai Liao, Dayong Wang
BACKGROUND: Honokiol, a compound extracted from Magnolia officinalis, has antifungal activities by inducing mitochondrial dysfunction and triggering apoptosis in Candida albicans. However, the mechanism of honokiol-induced oxidative stress is poorly understood. The present investigation was designed to determine the specific mitochondrial reactive oxygen species (ROS)-generation component. METHODS/RESULTS: We found that honokiol induced mitochondrial ROS accumulation, mainly superoxide anions (O2•-) measured by fluorescent staining method...
2017: PloS One
https://www.readbyqxmd.com/read/28834772/primary-analysis-of-the-mandarin-speaking-sub-study-within-the-sydney-diabetes-prevention-program
#8
Cecilia Y Taing, Alice A Gibson, Stephen Colagiuri, Philip Vita, Magnolia Cardona-Morrell, Adrian Bauman, Michael Moore, Mandy Williams, Andrew Milat, Jacky Hony, Sophia Lin, Melissa Gwizd, Maria A Fiatarone Singh
AIM: There is strong and consistent evidence from large scale randomised controlled trials that type 2 diabetes can be prevented or delayed through lifestyle modification which improves diet quality, increases physical activity and achieves weight loss in people at risk. Worldwide, the prevalence of type 2 diabetes is increasing in individuals of Chinese descent. Culturally tailored programs are required to address the risk in the Chinese population. This paper analyses effectiveness of a culturally tailored community-based lifestyle modification program (Sydney Diabetes Prevention Program (SDPP)) targeting Mandarin speakers...
August 7, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28822198/-comparison-between-ye-tianshi-and-xue-shengbai-in-treatment-of-distention-with-damp-heat
#9
Yu-Juan Li, Xiao-Yu Liu, Hou-Wang Jiang, Hong-Pei Li, Lian-Yu Xiao, Yan-Song Zhao
Ye Tianshi and Xue Shengbai were both epidemic febrile diseases specialists in same time of Qing dynasty. The Traditional Chinese Medicine Inheritance Support System was used to compare and analyze the therapeutic characteristics of these two specialists in treating damp-heat type fullness or distension in stomach. Distension is commonly caused by qi stagnation accompanied with damp-heat from internal and external factors. In treatment, separation of damp and heat and removing dampness and heat from sanjiao separately were their common therapeutic principles...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28817221/neuroprotective-effects-of-honokiol-from-chemistry-to-medicine
#10
REVIEW
Sylwia Talarek, Joanna Listos, Davide Barreca, Ester Tellone, Antoni Sureda, Seyed Fazel Nabavi, Nady Braidy, Seyed Mohammad Nabavi
The incidence of neurological disorders is growing in developed countries together with increased lifespan. Nowadays, there are still no effective treatments for neurodegenerative pathologies, which make necessary to search for new therapeutic agents. Natural products, most of them used in traditional medicine, are considered promising alternatives for the treatment of neurodegenerative diseases. Honokiol is a natural bioactive phenylpropanoid compound, belonging to the class of neolignan, found in notable amounts in the bark of Magnolia tree, and has been reported to exert diverse pharmacological properties including neuroprotective activities...
August 17, 2017: BioFactors
https://www.readbyqxmd.com/read/28748433/a-supplement-to-prof-shoji-shibata-s-achievements-the-history-of-sh%C3%A5-s%C3%A5-in-medicines-and-the-reason-why-magnolia-obovata-old-name-hoogashiwa-was-not-given-a-chinese-herbal-name-in-japan-s-oldest-anthology-man-y%C3%A5-sh%C3%A5
#11
REVIEW
Takeshi Kinoshita
Prof. Shoji Shibata (1916-2016) left behind remarkable achievements in the field of the history of pharmacy. Among those, the scientific survey on medicines preserved in Shōsō-in, globally known as the World Cultural Heritage, is of particular interest, drawing wide attention from scholars to the general public. Its most spectacular and also shocking study in the field of pharmacognosy will be the one on the true origin of Kōboku (Houpu) that seems quite ordinary from its name. Prof. Shibata revealed that it is of juglandaceous origin that is completely different from what is known today under the same name...
July 26, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28746938/magnolol-inhibits-the-growth-of-non-small-cell-lung-cancer-via-inhibiting-microtubule-polymerization
#12
Jia Shen, Hailin Ma, Tiancheng Zhang, Hui Liu, Linghua Yu, Guosheng Li, Huishuang Li, Meichun Hu
BACKGROUND: The tubulin/microtubule system, which is an integral component of the cytoskeleton, plays an essential role in mitosis. Targeting mitotic progression by disturbing microtubule dynamics is a rational strategy for cancer treatment. METHODS: Microtubule polymerization assay was performed to examine the effect of Magnolol (a novel natural phenolic compound isolated from Magnolia obovata) on cellular microtubule polymerization in human non-small cell lung cancer (NSCLC) cells...
July 26, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28736799/rankl-induced-osteoclastogenesis-is-suppressed-by-4-o-methylhonokiol-in-bone-marrow-derived-macrophages
#13
Kyung-Ran Park, Ji-Youn Kim, Eun-Cheol Kim, Hyung-Mun Yun, Jin Tae Hong
Magnolol, honokiol, and obovatol are well known bioactive constituents of the bark of Magnolia officinalis and have been reported to have beneficial effects in various diseases. We recently isolated a novel active compound, 4-O-methylhonokiol (4-O-MH) from the ethanol extract of M. officinalis, which was previously reported to have pharmacological effects including anti-inflammatory, anti-oxidative, and anti-aging activities. Here, we examined the pharmacological properties of 4-O-MH on osteoblast (bone-forming cells) and osteoclast (bone-resorbing cells) differentiation, and its underlying signaling pathways in primary cultured pre-osteoblasts and bone marrow macrophages...
July 24, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28731124/bmp7-mediates-the-anticancer-effect-of-honokiol-by-upregulating-p53-in-hct116-cells
#14
Rong-Xing Liu, Wen-Yan Ren, Yan Ma, Yun-Peng Liao, Han Wang, Jia-Hui Zhu, Hai-Tao Jiang, Ke Wu, Bai-Cheng He, Wen-Juan Sun
Colorectal cancer (CRC) is the second leading cause of cancer death. Hence, there is a great need to explore new efficacious drugs for the treatment of CRC. Honokiol (HNK), a natural product extracted from magnolia bark, processes various biological activities, including anticancer. In this study, we introduced cell viability assay, western blotting, real-time PCR and immunofluorescent staining to determine the anticancer effect of HNK, and the possible mechanism underlying this biological process. We found that HNK can inhibit the proliferation and induce apoptosis in HCT116 cells in a concentration- and time-dependent manner...
July 21, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28726741/magnolol-a-natural-polyphenol-attenuates-dextran-sulfate-sodium-induced-colitis-in-mice
#15
Ling Zhao, Hai-Tao Xiao, Huai-Xue Mu, Tao Huang, Ze-Si Lin, Linda L D Zhong, Guang-Zhi Zeng, Bao-Min Fan, Cheng-Yuan Lin, Zhao-Xiang Bian
Magnolol is a lignan with anti-inflammatory activity identified in Magnolia officinalis. Ulcerative colitis (UC), one of the types of inflammatory bowel disease (IBD), is a disease that causes inflammation and ulcers in the colon. To investigate the effect of magnolol in dextran sulfate sodium (DSS)-induced experimental UC model, male C57 mice were treated with 2% DSS drinking water for 5 consecutive days followed by intragastric administration with magnolol (5, 10 and 15 mg/kg) daily for 7 days. The results showed that magnolol significantly attenuated disease activity index, inhibited colonic shortening, reduced colonic lesions and suppressed myeloperoxidase (MPO) activity...
July 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28725003/distribution-of-salicifoline-in-freeze-fixed-stems-of-magnolia-kobus-as-observed-by-cryo-tof-sims
#16
Wakaba Okumura, Dan Aoki, Yasuyuki Matsushita, Masato Yoshida, Kazuhiko Fukushima
Alkaloids are basic nitrogen-containing chemicals that have important physiological and pharmacological characteristics. Many vascular plant species contain alkaloids, and their roles in planta are of interest. However, the detailed distribution of alkaloids remains unclear because of their low water solubility and low concentrations in plants. In this study, we visualized the distribution of salicifoline, a water-soluble quaternary ammonium alkaloid, in the freeze-fixed stems of Magnolia kobus by cryo time-of-flight secondary ion mass spectrometry...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28695220/chain-breaking-antioxidant-activity-of-hydroxylated-and-methoxylated-magnolol-derivatives-the-role-of-h-bonds
#17
Andrea Baschieri, Luana Pulvirenti, Vera Muccilli, Riccardo Amorati, Corrado Tringali
Chemical modification of magnolol, an uncommon dimeric neolignan contained in Magnolia genus trees, provides a unique array of polyphenols having interesting biological activity potentially related to radical scavenging. The chain-breaking antioxidant activity of four new hydroxylated and methoxylated magnolol derivatives was explored by experimental and computational methods. The measurement of the rate constant of the reaction with ROO˙ radicals (kinh) in an apolar solvent showed that the introduction of hydroxyl groups ortho to the phenolic OH in magnolol increased the kinh value, being 2...
July 26, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28693571/characterization-of-erythrose-reductase-from-yarrowia-lipolytica-and-its-influence-on-erythritol-synthesis
#18
Tomasz Janek, Adam Dobrowolski, Anna Biegalska, Aleksandra M Mirończuk
BACKGROUND: Erythritol is a natural sweetener that is used in the food industry. It is produced as an osmoprotectant by bacteria and yeast. Due to its chemical properties, it does not change the insulin level in the blood, and therefore it can be safely used by diabetics. Previously, it has been shown that erythrose reductase (ER), which catalyzes the final step, plays a crucial role in erythritol synthesis. ER reduces erythrose to erythritol with NAD(P)H as a cofactor. Despite many studies on erythritol synthesis by Yarrowia lipolytica, the enzymes involved in this metabolic pathway have ever been described...
July 11, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28689299/4-o-methylhonokiol-protects-from-alcohol-carbon-tetrachloride-induced-liver-injury-in-mice
#19
Eleonora Patsenker, Andrea Chicca, Vanessa Petrucci, Sheida Moghadamrad, Andrea de Gottardi, Jochen Hampe, Jürg Gertsch, Nasser Semmo, Felix Stickel
Alcoholic liver disease (ALD) is a leading cause of liver cirrhosis, liver cancer, and related mortality. The endocannabinoid system contributes to the development of chronic liver diseases, where cannabinoid receptor 2 (CB2) has been shown to have a protecting role. Thus, here, we investigated how CB2 agonism by 4'-O-methylhonokiol (MHK), a biphenyl from Magnolia grandiflora, affects chronic alcohol-induced liver fibrosis and damage in mice. A combination of alcohol (10% vol/vol) and CCl4 (1 ml/kg) was applied to C57BL/6 mice for 5 weeks...
July 8, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28621040/bioactive-neolignans-and-other-compounds-from-magnolia-grandiflora-l-isolation-and-antiplasmodial-activity
#20
Abdul Latif, Yongle Du, Seema R Dalal, Maria L Fernández-Murga, Emilio F Merino, Maria B Cassera, Michael Goetz, David G I Kingston
Bioassay-guided fractionation of a methanol extract of Magnolia grandiflora against Plasmodium falciparum yielded two new (1 and 2) and six known (3 - 8) bioactive compounds. The structures of the new compounds were assigned by mass spectrometric and 1D- and 2D-NMR data. Known compounds were identified by comparison of (1) H-NMR and MS data with literature data. The two known neolignans 3 and 4 showed moderate antiplasmodial activity with the IC50 values of 2.8 ± 0.1 and 3.4 ± 0.1 μm, respectively. Weak antiplasmodial activity was recorded for compounds 1, 2, 5, 6, 7, and 8, with the IC50 values of 38 ± 2, 23 ± 2, 16...
June 16, 2017: Chemistry & Biodiversity
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