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https://www.readbyqxmd.com/read/28621040/bioactive-neolignans-and-other-compounds-from-magnolia-grandiflora-l-isolation-and-antiplasmodial-activity
#1
Abdul Latif, Yongle Du, Seema R Dalal, Emilio F Merino, Maria B Cassera, Michael Goetz, David G I Kingston
Bioassay-guided fractionation of a methanol extract of Magnolia grandiflora against Plasmodium falciparum yielded two new (1 and 2) and six known (3 - 8) bioactive compounds. The structures of the new compounds were assigned by mass spectrometric and 1D and 2D NMR data. Known compounds were identified by comparison of (1) H NMR and MS data with literature data. The two known neolignans 3 and 4 showed moderate antiplasmodial activity with IC50 values of 2.8 ± 0.1 and 3.4 ± 0.1 μM, respectively. Weak antiplasmodial activity was recorded for compounds 1, 2, 5, 6, 7 and 8, with IC50 values of 38 ± 2, 23 ± 2, 16...
June 16, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28615048/integrated-metabolome-and-transcriptome-analysis-of-magnolia-champaca-identifies-biosynthetic-pathways-for-floral-volatile-organic-compounds
#2
Savitha Dhandapani, Jingjing Jin, Vishweshwaran Sridhar, Rajani Sarojam, Nam-Hai Chua, In-Cheol Jang
BACKGROUND: Magnolia champaca, commonly known as champak is a well-known tree due to its highly fragrant flowers. Champak floral scent is attributed to a complex mix of volatile organic compounds (VOCs). These aromatic flowers are widely used in flavors and fragrances industry. Despite its commercial importance, the VOC biosynthesis pathways in these flowers are largely unknown. Here, we combine metabolite and RNA sequencing (RNA-seq) analyses of fully opened champak flowers to discover the active VOC biosynthesis pathways as well as floral scent-related genes...
June 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28585905/polyphenols-from-flowers-of-magnolia-coco-and-their-anti-glycation-effects
#3
Nana Kato, Satoko Kawabe, Natsuki Ganeko, Morio Yoshimura, Yoshiaki Amakura, Hideyuki Ito
We investigated the inhibitory effects of several plant extracts on advanced glycation end-products (AGEs) formation. Among tested samples, the flower extract of Magnolia coco showed significant inhibition of AGE formation. We isolated and characterized procyanidin oligomer and four other compounds from the flowers, and evaluated their inhibitory effects on AGE formation and the AGE-derived crosslink-cleaving activity of the isolated compounds.
July 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28581518/activation-of-tumor-suppressor-lkb1-by-honokiol-abrogates-cancer-stem-like-phenotype-in-breast-cancer-via-inhibition-of-oncogenic-stat3
#4
S Sengupta, A Nagalingam, N Muniraj, M Y Bonner, P Mistriotis, A Afthinos, P Kuppusamy, D Lanoue, S Cho, P Korangath, M Shriver, A Begum, V F Merino, C-Y Huang, J L Arbiser, W Matsui, B Győrffy, K Konstantopoulos, S Sukumar, P A Marignani, N K Saxena, D Sharma
Tumor suppressor and upstream master kinase Liver kinase B1 (LKB1) plays a significant role in suppressing cancer growth and metastatic progression. We show that low-LKB1 expression significantly correlates with poor survival outcome in breast cancer. In line with this observation, loss-of-LKB1 rendered breast cancer cells highly migratory and invasive, attaining cancer stem cell-like phenotype. Accordingly, LKB1-null breast cancer cells exhibited an increased ability to form mammospheres and elevated expression of pluripotency-factors (Oct4, Nanog and Sox2), properties also observed in spontaneous tumors in Lkb1(-/-) mice...
June 5, 2017: Oncogene
https://www.readbyqxmd.com/read/28560444/schisandrin-b-attenuates-the-inflammatory-response-oxidative-stress-and-apoptosis-induced-by-traumatic-spinal-cord-injury-via-inhibition-of-p53-signaling-in-adult-rats
#5
D Q Xin, Z M Hu, H J Huo, X J Yang, D Han, W H Xing, Y Zhao, Q H Qiu
Schisandrin B is an active monomer of the Chinese magnolia vine (Schisandra chinensis) that can reduce transaminase activity in liver cells, inhibit lipid peroxidation, enhance antioxidant status, has protective effects in the liver and has antitumor effects. The present study investigated the potential protective effects of schisandrin B on the p53 signaling pathway in attenuating the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury (TSCI) in adult rats. Behavioral examination, inclined plate test and spinal cord water content were used to evaluate the protective effect of schisandrin B in TSCI rats...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28557279/development-of-a-novel-hollow-fiber-liquid-phase-microextraction-based-on-oil-in-salt-and-its-comparison-with-a-conventional-method
#6
Miao-Miao Li, Shuang Hu, Xuan Chen, Xiao-Hong Bai
A novel hollow-fiber liquid-phase microextraction based on oil-in-salt was proposed and introduced for the simultaneous extraction and enrichment of the main active compounds of hesperidin, honokiol, shikonin, magnolol, emodin and β,β'-dimethylacrylshikonin in a formula of Zi-Cao-Cheng-Qi Decoction and the single herbs, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Radix et Rhizoma and Lithospermum erythrorhizon, before their analysis by high-performance liquid chromatography. The results obtained by the proposed procedure were compared with those obtained by conventional hollow-fiber liquid-phase microextraction, and the proposed procedure mechanism was described...
May 30, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28546825/efficient-isolation-of-magnolia-protoplasts-and-the-application-to-subcellular-localization-of-mdehsf1
#7
Yamei Shen, Dong Meng, Kim McGrouther, Junhong Zhang, Lailiang Cheng
BACKGROUND: Magnolia is a woody ornamental plant, which is widely used in urban landscaping. However, its lengthy juvenile period and recalcitrance to regeneration impedes functional characterization of its genes. RESULTS: We developed an efficient protoplast isolation and transient expression system for Magnolia denudata × Magnolia acuminata 'Yellow River'. The highest yield of protoplasts was obtained from young leaves digested in 3% Cellulase R10, 0.8% Macerozyme R10, 0...
2017: Plant Methods
https://www.readbyqxmd.com/read/28539883/feature-binding-of-common-everyday-items-is-not-affected-by-age
#8
Serge Hoefeijzers, Alfredis González Hernández, Angela Magnolia Rios, Mario A Parra
There is a surge of studies confirming that old age spares the ability to bind in visual working memory (VWM) multiple features within singular object representations. Furthermore, it has been suggested that such ability may also be independent of the cultural background of the assessed individual. However, this evidence has been gathered with tasks that use arbitrary bindings of unfamiliar features. Whether age spares memory binding functions when the memoranda are features of everyday life objects remains less well explored...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28517911/is-there-a-potential-of-misuse-for-magnolia-officinalis-compounds-metabolites
#9
Fabrizio Schifano, Valentina Guarino, Duccio G Papanti, Jacopo Baccarin, Laura Orsolini, John M Corkery
OBJECTIVE: Magnolia bark contains magnolol, metabolized to tetrahydromagnolol and honokiol, with both GABA-ergic/cannabimimetic activities, hence of possible attraction to vulnerable individuals/recreational misusers. METHODS: A literature review, assessment of related anecdotal online Magnolia misuse's reports and an overview of Magnolia products' online acquisition possibilities has been here described. RESULTS: No peer-reviewed papers about Magnolia abuse/misuse/dependence/addiction were identified...
May 18, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28502866/what-is-inappropriate-hospital-use-for-elderly-people-near-the-end-of-life-a-systematic-review
#10
REVIEW
Magnolia Cardona-Morrell, James C H Kim, Mikkel Brabrand, Blanca Gallego-Luxan, Ken Hillman
BACKGROUND: Older people with advance chronic illness use hospital services repeatedly near the end of life. Some of these hospitalizations are considered inappropriate. AIM: To investigate extent and causes of inappropriate hospital admission among older patients near the end of life. METHODS: English language publications in Medline, EMBASE, PubMed, Cochrane library, and the grey literature (January 1995-December 2016) covering community and nursing home residents aged ≥60years admitted to hospital...
May 11, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28499955/transcriptomic-analysis-of-saccharomyces-cerevisiae-upon-honokiol-treatment
#11
Xiaolong Zhu, Shenshen Zou, Youbin Li, Yongheng Liang
Honokiol (HNK), one of the main medicinal components in Magnolia officinalis, possesses antimicrobial activity against a variety of pathogenic bacteria and fungi. However, little is known of the molecular mechanisms underpinning the antimicrobial activity. To explore the molecular mechanism of its antifungal activity, we determined the effects of HNK on the mRNA expression profile of Saccharomyces cerevisiae using a DNA microarray approach. HNK markedly induced the expression of genes related to iron uptake and homeostasis...
May 10, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28493080/therapeutic-action-of-honokiol-on-postoperative-ileus-via-downregulation-of-inos-gene-expression
#12
Taiki Mihara, Shoma Mikawa, Noriyuki Kaji, Mari Endo, Tetsuro Oikawa, Jan Tong-Rong, Hiroshi Ozaki, Masatoshi Hori
Postoperative ileus is a common complication after intra-abdominal surgery. Nitric oxide produced by macrophages in the inflamed gastrointestinal tract plays a crucial role in the pathogeny of postoperative ileus. Honokiol, extracted from the bark of Magnolia spp., is a natural compound with a biphenolic structure. In the present study, we examined the effect of honokiol on postoperative ileus and discussed its site of action. Postoperative ileus model mice were generated by surgical intestinal manipulation...
May 10, 2017: Inflammation
https://www.readbyqxmd.com/read/28490739/honokiol-inhibits-ultraviolet-radiation-induced-immunosuppression-through-inhibition-of-ultraviolet-induced-inflammation-and-dna-hypermethylation-in-mouse-skin
#13
Ram Prasad, Tripti Singh, Santosh K Katiyar
Ultraviolet (UV) radiation exposure induces immunosuppression, which contributes to the development of cutaneous malignancies. We investigated the effects of honokiol, a phytochemical found in plants of the genus Magnolia, on UVB-induced immunosuppression using contact hypersensitivity (CHS) as a model in C3H/HeN mice. Topical application of honokiol (0.5 and 1.0 mg/cm(2) skin area) had a significant preventive effect on UVB-induced suppression of the CHS response. The inflammatory mediators, COX-2 and PGE2, played a key role in this effect, as indicated by honokiol inhibition of cyclooxygenase-2 (COX-2) expression and PGE2 production in the UVB-exposed skin...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28485933/hplc-based-activity-profiling-for-gabaa-receptor-modulators-in-extracts-validation-of-an-approach-utilizing-a-larval-zebrafish-locomotor-assay
#14
Fahimeh Moradi-Afrapoli, Samad Nejad Ebrahimi, Martin Smiesko, Matthias Hamburger
Gamma-aminobutyric acid type A (GABAA) receptors are major inhibitory neurotransmitter receptors in the central nervous system and a target for numerous clinically important drugs used to treat anxiety, insomnia, and epilepsy. A series of allosteric GABAA receptor agonists was identified previously with the aid of HPLC-based activity profiling, whereby activity was tracked with an electrophysiological assay in Xenopus laevis oocytes. To accelerate the discovery process, an approach has been established for HPLC-based profiling using a larval zebrafish (Danio rerio) seizure model induced by pentylenetetrazol (PTZ), a pro-convulsant GABAA receptor antagonist...
May 9, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28469575/honokiol-alleviates-hypertrophic-scar-by-targeting-transforming-growth-factor-%C3%AE-smad2-3-signaling-pathway
#15
Danyang Zhao, Yu Wang, Chao Du, Shengzhou Shan, Yifan Zhang, Zijing Du, Dong Han
Hypertrophic scar (HPS) presents as excessive extracellular matrix deposition and abnormal function of fibroblasts. However, there is no single satisfactory method to prevent HPS formation so far. Here, we found that honokiol (HKL), a natural compound isolated from Magnolia tree, had an inhibitory effect on HPS both in vitro and in vivo. Firstly, HKL could dose-dependently down-regulate the mRNA and protein levels of type I collagen, type III collagen, and α-smooth muscle actin (α-SMA) in hypertrophic scar-derived fibroblasts (HSFs)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28468305/inhibitory-effects-of-dimethyllirioresinol-epimagnolin-a-eudesmin-fargesin-and-magnolin-on-cytochrome-p450-enzyme-activities-in-human-liver-microsomes
#16
Ju-Hyun Kim, Soon-Sang Kwon, Hyeon-Uk Jeong, Hye Suk Lee
Magnolin, epimagnolin A, dimethyllirioresinol, eudesmin, and fargesin are pharmacologically active tetrahydrofurofuranoid lignans found in Flos Magnoliae. The inhibitory potentials of dimethyllirioresinol, epimagnolin A, eudesmin, fargesin, and magnolin on eight major human cytochrome P450 (CYP) enzyme activities in human liver microsomes were evaluated using liquid chromatography-tandem mass spectrometry to determine the inhibition mechanisms and inhibition potency. Fargesin inhibited CYP2C9-catalyzed diclofenac 4'-hydroxylation with a Ki value of 16...
May 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28465484/sirt3-klf15-signaling-ameliorates-kidney-injury-induced-by-hypertension
#17
Na Li, Jie Zhang, Xuefang Yan, Chen Zhang, Hui Liu, Xiaolan Shan, Jingyuan Li, Yi Yang, Chengmin Huang, Peng Zhang, Yun Zhang, Peili Bu
Renal fibrosis participates in the progression of hypertension-induced kidney injury. The effect of SIRT3, a member of the NAD+-dependent deacetylase family, in hypertensive nephropathy remains unclear. In this study, we found that SIRT3 was reduced after angiotensin II (AngII) treatment both in vivo and in vitro. Furthermore, SIRT3-knockout mice aggravated hypertension-induced renal dysfunction and renal fibrosis via chronic AngII infusion (2000 ng/kg per minute for 42 days). On the contrary, SIRT3-overexpression mice attenuated AngII-induced kidney injury compared with wild-type mice...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28443025/honokiol-induces-apoptosis-g1-arrest-and-autophagy-in-kras-mutant-lung-cancer-cells
#18
Lian-Xiang Luo, Ying Li, Zhong-Qiu Liu, Xing-Xing Fan, Fu-Gang Duan, Run-Ze Li, Xiao-Jun Yao, Elaine Lai-Han Leung, Liang Liu
Aberrant signaling transduction induced by mutant KRAS proteins occurs in 20∼30% of non-small cell lung cancer (NSCLC), however, a direct and effective pharmacological inhibitor targeting KRAS has not yet reached the clinic to date. Honokiol, a small molecular polyphenol natural biophenolic compound derived from the bark of magnolia trees, exerts anticancer activity, however, its mechanism remains unknown. In this study, we sought to investigate the in vitro effects of honokiol on NSCLC cell lines harboring KRAS mutations...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28424715/temporal-petal-closure-benefits-reproductive-development-of-magnolia-denudata-magnoliaceae-in-early-spring
#19
Liya Liu, Chulan Zhang, Xiangyu Ji, Zhixiang Zhang, Ruohan Wang
The Magnoliaceae shows strong phylogenetic niche conservatism, in which temporal petal closure has been extensively reported. However, it is yet elusive whether temporal petal closure is an idle floral character inherited from their ancestors or an adaptive trait to their habitats. Here, we monitored the process of temporal floral closure and re-opening in a thermogenic plant, Magnolia denudata (Magnoliaceae). Furthermore, we artificially interrupted temporal petal closure and investigated its effects on development of female and male gametophytes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28424569/current-knowledge-of-schisandra-chinensis-turcz-baill-chinese-magnolia-vine-as-a-medicinal-plant-species-a-review-on-the-bioactive-components-pharmacological-properties-analytical-and-biotechnological-studies
#20
REVIEW
Agnieszka Szopa, Radosław Ekiert, Halina Ekiert
Schisandra chinensis Turcz. (Baill.) is a plant species whose fruits have been well known in Far Eastern medicine for a long time. However, schisandra seems to be a plant still underestimated in contemporary therapy still in the countries of East Asia. The article presents latest available information on the chemical composition of this plant species. Special attention is given to dibenzo cyclooctadiene lignans. In addition, recent studies of the biological activity of dibenzocyclooctadiene lignans and schisandra fruit extracts are recapitulated...
2017: Phytochemistry Reviews: Proceedings of the Phytochemical Society of Europe
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