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https://www.readbyqxmd.com/read/27558585/efficacy-and-tolerability-of-meratrim-for-weight-management-a-randomized-double-blind-placebo-controlled-study-in-healthy-overweight-human-subjects
#1
Venkateshwarlu Kudiganti, Raveendra Ramamurthy Kodur, Sushma Raveendra Kodur, Manjunath Halemane, Dheeraj Kumar Deep
BACKGROUND: Meratrim is a blend of two plant extracts obtained from Sphaeranthus indicus flower heads and Garcinia mangostana fruit rinds. Previous studies have demonstrated that Meratrim is effective for weight management in obese individuals. The objective of this study was to assess the efficacy and tolerability of Meratrim in managing body weight in healthy overweight subjects. METHODS: Sixty participants with a mean BMI of 28.3 kg/m(2) were randomized into two groups receiving either 400 mg of Meratrim twice daily or two identical placebo capsules for a period of 16 weeks...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/26953617/a-new-antifungal-eudesmanolide-glycoside-isolated-from-sphaeranthus-indicus-linn-family-compositae
#2
Bhuwan B Mishra, Navneet Kishore, Vinod K Tiwari
A new antifungal eudesmanolide glycoside 11,13-dihydro-3-O-(β-digitoxopyranose)-7α-hydroxy eudasman-6,12-olide (2) in addition to known compounds 1 and 3, has been isolated from Sphaeranthus indicus Linn. Its structure was determined by spectral analysis (UV, IR, 1D and 2D NMR and mass spectrum).
March 8, 2016: Natural Product Research
https://www.readbyqxmd.com/read/26941538/isolation-and-characterization-of-chemopreventive-agent-from-sphaeranthus-amaranthoides-burm-f
#3
S Gayatri, R Suresh, C Uma Maheswara Reddy, K Chitra
OBJECTIVE: To investigate the in vitro cytotoxic effect and to isolate and characterize a chemopreventive secondary metabolite from Sphaeranthus amaranthoides Burm F (sivakaranthai). MATERIALS AND METHODS: In vitro cytotoxic effect was carried out by 3 (4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide assay. Different concentrations of the extracts were tested on three different cell lines namely A549, HT29, and MCF7. The chloroform extract was subjected to column chromatography, and the isolated compound was characterized by various spectral methods and by single crystal X-ray crystallography...
January 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/26064179/a-novel-anti-inflammatory-natural-product-from-sphaeranthus-indicus-inhibits-expression-of-vcam1-and-icam1-and-slows-atherosclerosis-progression-independent-of-lipid-changes
#4
Rai Ajit K Srivastava, Sapna Mistry, Somesh Sharma
A large body of evidence suggests that atherosclerosis is an inflammatory disease, in which cytokines and growth factors play a major role in disease progression. The methanolic extracts of Sphaeranthus indicus as well as its active ingredient, 7-hydroxy frullanoide (7-HF), are shown to suppress LPS-induced cytokine production from mononuclear cells, and inhibit the expression of VCAM1, ICAM1 and E-selectin by TNF-α- stimulated HUVECs in a concentration-dependent manner. We tested the hypothesis that the inhibition of cytokines and adhesion molecules should attenuate the progression of atherosclerosis, independent of changes in the lipid profile...
2015: Nutrition & Metabolism
https://www.readbyqxmd.com/read/25829795/assessment-of-in-vitro-cytotoxicity-and-in-vivo-antitumor-activity-of-sphaeranthus-amaranthoides-burm-f
#5
S Gayatri, C Uma Maheswara Reddy, K Chitra, V Parthasarathy
BACKGROUND: A number of plants have been used in Indian system of medicine such as ayurveda, unani and siddha, but most of these plants were not explored properly. Sphaeranthus amaranthoides (SA) Burm.f., is one such plant used as an energizer in siddha. OBJECTIVE: To evaluate the anticancer effect of chloroform extract of the whole plant of SA Burm.f. against Ehrlich ascites carcinoma bearing Swiss albino mice. MATERIALS AND METHODS: The anticancer effect of chloroform extract was investigated in Swiss albino mice bearing Ehrlich ascites carcinoma at two different dose levels...
April 2015: Pharmacognosy Research
https://www.readbyqxmd.com/read/25737834/ovicidal-and-oviposition-deterrent-activities-of-medicinal-plant-extracts-against-aedes-aegypti-l-and-culex-quinquefasciatus-say-mosquitoes-diptera-culicidae
#6
Appadurai Daniel Reegan, Munusamy Rajiv Gandhi, Micheal Gabriel Paulraj, Savarimuthu Ignacimuthu
OBJECTIVES: To evaluate the ovicidal and oviposition deterrent activities of five medicinal plant extracts namely Aegle marmelos (Linn.), Limonia acidissima (Linn.), Sphaeranthus indicus (Linn.), Sphaeranthus amaranthoides (burm.f), and Chromolaena odorata (Linn.) against Culex quinquefasciatus and Aedes aegypti mosquitoes. Three solvents, namely hexane, ethyl acetate, and methanol, were used for the preparation of extracts from each plant. METHODS: Four different concentrations-62...
February 2015: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/25680508/safety-and-toxicological-evaluation-of-meratrim%C3%A2-an-herbal-formulation-for-weight-management
#7
Zainulabedin M Saiyed, Krishanu Sengupta, Alluri V Krishnaraju, Golakoti Trimurtulu, Francis C Lau, James P Lugo
Meratrim is a unique dietary ingredient consisting of extracts from Sphaeranthus indicus flower heads and Garcinia mangostana fruit rind. Clinical studies have demonstrated that Meratrim is effective and well-tolerated in weight management. Herein we assessed the broad spectrum safety of Meratrim in a battery of in vitro and animal toxicological studies including a sub-chronic repeated-dose 13-week oral toxicity study to determine the no-observable-adverse-effect-level (NOAEL). The LD50 levels of Meratrim in Sprague-Dawley (SD) rats, as determined by the acute oral and dermal toxicity studies, were >5000 and >2000 mg/kg body weight, respectively...
April 2015: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/24347924/review-on-sphaeranthus-indicus-linn-ko%C3%A1-%C3%A1-aikkarantai
#8
REVIEW
Shakila Ramachandran
Sphaeranthus indicus Linn. is from the aroma family Asteraceae. It is also known with other synonyms such as Munditika, Mundi, Shravana, Bhikshu, Tapodhana, Mahashravani, Shravanahva, Shravanashirshaka. It is abundantly distributed in damp areas in plains and also as a weed in the rice fields. In the Indian system of medicine, the plant as a whole plant or its different anatomical parts viz., leaf, stem, bark, root, flower and seed are widely used for curing many diseases. The plant is bitter, stomachic, restorative, alterative, pectoral, demulcent and externally soothing...
July 2013: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/24049466/induction-of-sexual-stage-and-colony-morphology-of-some-isolates-of-sclerotium-rolfsii-causing-spotted-leaf-rot-in-plants
#9
M K Pandey, B K Sarma, U P Singh
Twenty-two isolates of Sclerotium rolfsii causing spotted leaf rot from Varanasi, India were grown on 6% Cyperus rotundus rhizome meal agar (CRMA) medium for the induction of athelial stage (Athelia rolfsii). Only one isolate obtained from Sphaeranthus indicus formed basidial stage on CRMA medium while the other 21 isolates did not. Basidial stage was also produced in S. indicus isolate at different concentrations (5.5, 6.0 and 6.5% w/v) of CRMA medium. Size of basidia, sterigmata and basidiospores of this isolate was measured...
March 2005: Mycobiology
https://www.readbyqxmd.com/read/23784895/efficacy-and-tolerability-of-a-novel-herbal-formulation-for-weight-management
#10
RANDOMIZED CONTROLLED TRIAL
J S Stern, J Peerson, A T Mishra, M V Sadasiva Rao, K P Rajeswari
OBJECTIVE: To evaluate the efficacy of an herbal blend. DESIGN AND METHODS: A randomized, double-blind, clinical trial in 60 subjects with body mass index (BMI) between 30 and 40 kg/m(2) . Participants were randomized into two groups receiving either 400 mg herbal capsules or 400 mg placebo capsules twice daily. The herbal blend comprises of extracts from Sphaeranthus indicus and Garcinia mangostana. Participants received a standard diet (2,000 kcal per day) and walked 30 min 5 days per week...
May 2013: Obesity
https://www.readbyqxmd.com/read/23767862/efficacy-and-tolerability-of-an-herbal-formulation-for-weight-management
#11
RANDOMIZED CONTROLLED TRIAL
Judith S Stern, Jan Peerson, Artatrana T Mishra, Venkata Sadasiva Rao Mathukumalli, Poorna Rajeswari Konda
The clinical effects and tolerability of a novel herbal formulation comprising the extracts of Sphaeranthus indicus and Garcinia mangostana were assessed in two similarly designed randomized, double-blind, placebo-controlled, clinical trials in 100 human subjects with a body mass index (BMI) between 30 and 40 kg/m². Participants were randomized into two groups receiving either 400 mg of herbal blend twice daily or two identical placebo capsules. All subjects received three meals (2000 kcal/day) throughout the study and walked 5 days a week for 30 min...
June 2013: Journal of Medicinal Food
https://www.readbyqxmd.com/read/23710567/evaluation-of-5%C3%AE-reductase-inhibitory-activity-of-certain-herbs-useful-as-antiandrogens
#12
A Nahata, V K Dixit
This study demonstrates 5α-reductase inhibitory activity of certain herbs useful in the management of androgenic disorders. Ganoderma lucidum (Curtis) P. Karst (GL), Urtica dioica Linn. (UD), Caesalpinia bonducella Fleming. (CB), Tribulus terrestris Linn. (TT), Pedalium murex Linn. (PM), Sphaeranthus indicus Linn. (SI), Cuscuta reflexa Roxb. (CR), Citrullus colocynthis Schrad. (CC), Benincasa hispida Cogn. (BH), Phyllanthus niruri Linn. (PN) and Echinops echinatus Linn. (EE) were included in the study. Petroleum ether, ethanol and aqueous extracts of these herbs were tested for their 5α-reductase inhibitory activity against the standard 5α-reductase inhibitor, finasteride...
August 2014: Andrologia
https://www.readbyqxmd.com/read/23509751/evaluation-of-antioxidant-and-wound-healing-potentials-of-sphaeranthus-amaranthoides-burm-f
#13
R Geethalakshmi, C Sakravarthi, T Kritika, M Arul Kirubakaran, D V L Sarada
BACKGROUND: Sphaeranthus amaranthoides commonly known as sivakaranthai is used in folklore medicine for the treatment of skin diseases. METHODS: The antioxidant activity of the extract and its fraction was evaluated by using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, total antioxidant capacity, and total phenolic content. The tested plant extracts showed variable degrees of antioxidant activity. In the present study, methanolic extract of the whole plant of S...
2013: BioMed Research International
https://www.readbyqxmd.com/read/23074885/antiparasitic-and-anticancer-carvotacetone-derivatives-of-sphaeranthus-bullatus
#14
Francis Machumi, Abiy Yenesew, Jacob O Midiwo, Matthias Heydenreich, Erich Kleinpeter, Babu L Tekwani, Shabana I Khan, Larry A Walker, Ilias Muhammad
The CH2Cl2-MeOH (1:1) extract of the aerial parts of Sphaeranthus bullatus, an annual herb native to tropical East Africa, showed activity against chloroquine sensitive D6 (IC50 9.7 microg/mL) and chloroquine resistant W2 (IC50 15.0 microg/mL) strains of Plasmodium falciparum. Seventeen secondary metabolites were isolated from the extract through conventional chromatographic techniques and identified using various spectroscopic methods. The compounds were evaluated for their in vitro antiplasmodial, antileishmanial and anticancer activities revealing activity of four carvotacetone derivatives, namely 3-acetoxy-7-hydroxy-5-tigloyloxycarvotacetone (1), 3,7-dihydroxy-5-tigloyloxycarvotacetone (2), 3-acetoxy-5,7-dihydroxycarvotacetone (3) and 3,5,7-trihydroxy-carvotacetone (4); with antiplasmodial IC50 values of 1...
September 2012: Natural Product Communications
https://www.readbyqxmd.com/read/23023564/sphaeranthus-indicus-flower-derived-constituents-exhibits-synergistic-effect-against-acetylcholinesterase-and-possess-potential-antiamnestic-activity
#15
Mayurkumar B Patel, Dipa Amin
OBJECTIVE: The present investigation was aimed at discovery of novel acetylcholinesterase (AChE) inhibitors. METHODS: In vitro AchE inhibitory activity of various extracts of Sphaeranthus indicus flower heads was carried out. The petroleum ether fraction of S. indicus flowers (SIPE) exhibited significant activity. The fraction was found to be rich in sesquiterpene lactone content possibly responsible for in vitro AChE inhibition. In further study, the antiamnesic activities of SIPE in mice on the learning and memory impairments induced by scopolamine (1...
2012: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/22914874/sphaeranthus-indicus-induces-apoptosis-through-mitochondrial-dependent-pathway-in-hl-60-cells-and-exerts-cytotoxic-potential-on-several-human-cancer-cell-lines
#16
Alok Nahata, Arpita Saxena, Nitasha Suri, Ajit Kumar Saxena, Vinod Kumar Dixit
PURPOSE: The study was designed to screen Sphaeranthus indicus, Ganoderma lucidum, and Urtica dioica for their anticancer activity against human cancer cell lines. Phytochemical screening of active extracts was also planned. METHODS: Petroleum ether, ethanolic, and aqueous extracts of S indicus Linn, G lucidum P Karst, and U dioica Linn were subjected to cytotoxicity studies using 7 different cancer cell lines. Potent cytotoxicity was noted in petroleum ether extract of S indicus (SIP), which inhibited proliferation of various cancer cell lines...
May 2013: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/22759701/the-treatment-of-jaundice-with-medicinal-plants-in-indigenous-communities-of-the-sub-himalayan-region-of-uttarakhand-india
#17
Jyotsana Sharma, Sumeet Gairola, R D Gaur, R M Painuli
ETHNOPHARMACOLOGICAL RELEVANCE: Inspite of tremendous advances made in allopathic medical practices, herbs still play an important role in the management of various liver diseases. A large number of plants and formulations have been claimed to have hepatoprotective activity. Jaundice is a symptom, indicative of the malfunctioning of the liver. This paper provides ethnomedicinal information on the plants used to treat jaundice by three important indigenous communities, i.e., nomadic Gujjars, Tharu and Bhoxa of Sub-Himalayan region, Uttarakhand, India...
August 30, 2012: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/22562235/larvicidal-efficacy-of-sphaeranthus-indicus-cleistanthus-collinus-and-murraya-koenigii-leaf-extracts-against-filarial-vector-culex-quinquefasciatus-say-diptera-culicidae
#18
Kalimuthu Kovendan, Subramaniam Arivoli, Rajan Maheshwaran, Kathirvelu Baskar, Savariar Vincent
Sphaeranthus indicus, Cleistanthus collinus and Murraya koenigii leaf extracts were tested against the third instar larvae of Culex quinquefasciatus. The plant material was shade dried at room temperature and powdered coarsely. From each plant, 500 g powder was macerated with 1.5 L of hexane, chloroform and ethyl acetate sequentially for a period of 72 h each and filtered. The yield of the S. indicus, C. collinus and M. koenigii crude extracts by hexane, chloroform and ethyl acetate was 9.16, 11.71 and 10.83 g for S...
September 2012: Parasitology Research
https://www.readbyqxmd.com/read/22557345/preliminary-phytochemical-screening-of-some-indian-medicinal-plants
#19
A Doss
Alkaloids, tannins, saponins, steroid, terpenoid, flavonoids, phenolic compounds and cardie glycoside distribution in five medicinal plants belonging to different families were assessed and compared. The medicinal plants investigated were Asteracantha longifolia (L.) Nees, Psassiflora edulis Sims, Berberis tinctoria Lesch, Sphaeranthus indicus Linn, and Solanum trilobatum Linn. All the plants were found to contain Phenols, Cardiac glycosides, Steroids, Saponins and Tannin except for the absence of flavonoids and Terpenoids in A...
October 2009: Ancient Science of Life
https://www.readbyqxmd.com/read/21790496/effect-of-ethanol-extract-of-sphaeranthus-indicus-on-cisplatin-induced-nephrotoxicity-in-rats
#20
Jessy Elizabeth Mathew, Alex Joseph, Keloth Srinivasan, Seekarajapuram Vachala Dinakaran, Anand Mantri, Vinit Movaliya
Cisplatin is an anticancer drug extensively used against a variety of cancers. Cisplatin chemotherapy is found to manifest dose-dependent nephrotoxicity. Depletion of the renal antioxidant defence system has been suggested to be the main cause of cisplatin-induced nephrotoxicity. The purpose of this study is to investigate whether the ethanol extract of entire plant of Sphaeranthus indicus could reduce the intensity of toxicity in albino rats. Nephrotoxicity was assessed by determining the serum creatinine and urea levels and renal antioxidant status in rats after cisplatin administration (12 mg kg(-1) body weight, i...
2012: Natural Product Research
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