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https://www.readbyqxmd.com/read/28534217/autism-spectrum-disorder-associated-genes-and-the-development-of-dentate-granule-cells
#1
REVIEW
Hidenori Ito, Rika Morishita, Koh-Ichi Nagata
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by severe clinical symptoms such as the deficiency of the social communication, repetitive and stereotyped behaviors, and restricted interests. Although complex genetic and environmental factors are thought to contribute to the development of ASD, the precise etiologies are largely unknown. Neuroanatomical observations have been made of developmental abnormalities in different brain regions, including dentate gyrus of hippocampus, which is widely accepted as the center for learning and memory...
May 22, 2017: Medical Molecular Morphology
https://www.readbyqxmd.com/read/28533516/asd-restricted-and-repetitive-behaviors-associated-at-17q21-33-genes-prioritized-by-expression-in-fetal-brains
#2
R M Cantor, L Navarro, H Won, R L Walker, J K Lowe, D H Geschwind
Autism spectrum disorder (ASD) is a behaviorally defined condition that manifests in infancy or early childhood as deficits in communication skills and social interactions. Often, restricted and repetitive behaviors (RRBs) accompany this disorder. ASD is polygenic and genetically complex, so we hypothesized that focusing analyses on intermediate core component phenotypes, such as RRBs, can reduce genetic heterogeneity and improve statistical power. Applying this approach, we mined Caucasian genome-wide association studies (GWAS) data from two of the largest ASD family cohorts, the Autism Genetics Resource Exchange and Autism Genome Project (AGP)...
May 23, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28528329/the-interrater-reliability-of-the-autism-diagnostic-interview-revised-adi-r-in-clinical-settings
#3
Eric Zander, Charlotte Willfors, Steve Berggren, Christina Coco, Anette Holm, Ida Jifält, Renata Kosieradzki, Jenny Linder, Viviann Nordin, Karin Olafsdottir, Sven Bölte
BACKGROUND: The Autism Diagnostic Interview-Revised (ADI-R) is considered a first choice assessment tool in autism spectrum disorder. Nevertheless, despite its wide use in psychiatric practice and recommendations by various clinical guidelines, its interrater reliability has predominantly been confirmed in research settings by specially trained, research reliability interviewers. The reliability of ADI-R assessments among clinicians has not yet been established. Therefore, this study examined the spontaneous interrater reliability of the ADI-R in a naturalistic clinical multicenter setting...
May 20, 2017: Psychopathology
https://www.readbyqxmd.com/read/28524075/examining-the-overlap-between-autism-spectrum-disorder-and-22q11-2-deletion-syndrome
#4
Opal Ousley, A Nichole Evans, Samuel Fernandez-Carriba, Erica L Smearman, Kimberly Rockers, Michael J Morrier, David W Evans, Karlene Coleman, Joseph Cubells
22q11.2 deletion syndrome (22q11.2DS) is a genomic disorder reported to associate with autism spectrum disorders (ASDs) in 15-50% of cases; however, others suggest that individuals with 22q11.2DS present psychiatric or behavioral features associated with ASDs, but do not meet full criteria for ASD diagnoses. Such wide variability in findings may arise in part due to methodological differences across studies. Our study sought to determine whether individuals with 22q11.2DS meet strict ASD diagnostic criteria using research-based guidelines from the Collaborative Programs of Excellence in Autism (CPEA), which required a gathering of information from three sources: the Autism Diagnostic Interview-Revised (ADI-R), the Autism Diagnostic Observational Schedule (ADOS), and a clinician's best-estimate diagnosis...
May 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28518074/eliciting-and-analyzing-male-mouse-ultrasonic-vocalization-usv-songs
#5
Jonathan Chabout, Joshua Jones-Macopson, Erich D Jarvis
Mice produce ultrasonic vocalizations (USVs) in a variety of social contexts throughout development and adulthood. These USVs are used for mother-pup retrieval(1), juvenile interactions(2), opposite and same sex interactions(3)(,)(4)(,)(5), and territorial interactions(6). For decades, the USVs have been used by investigators as proxies to study neuropsychiatric and developmental or behavioral disorders(7)(,)(8)(,)(9), and more recently to understand mechanisms and evolution of vocal communication among vertebrates(10)...
May 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28512766/mental-health-outcomes-of-developmental-coordination-disorder-in-late-adolescence
#6
Ian Harrowell, Linda Hollén, Raghu Lingam, Alan Emond
AIM: To assess the relationship between developmental coordination disorder (DCD) and mental health outcomes in late adolescence. METHOD: Data were analyzed from the Avon Longitudinal Study of Parents and Children. Moderate-to-severe DCD was defined at 7 to 8 years according to the DSM-IV-TR criteria. Mental health was assessed at 16 to 18 years using self-reported questionnaires: Strengths and Difficulties Questionnaire, Short Moods and Feelings Questionnaire, and the Warwick-Edinburgh Mental Well-being Scale...
May 16, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28511484/efficacy-of-structured-yoga-intervention-for-sleep-gastrointestinal-and-behaviour-problems-of-asd-children-an-exploratory-study
#7
Kumar Narasingharao, Balaram Pradhan, Janardhana Navaneetham
INTRODUCTION: Autism Spectrum Disorder (ASD) is a neuro developmental disorder which appears at early childhood age between 18 and 36 months. Apart from behaviour problems ASD children also suffer from sleep and Gastrointestinal (GI) problems. Major behaviour problems of ASD children are lack of social communication and interaction, less attention span, repetitive and restrictive behaviour, lack of eye to eye contact, aggressive and self-injurious behaviours, sensory integration problems, motor problems, deficiency in academic activities, anxiety and depression etc...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28509404/family-therapy-for-autism-spectrum-disorders
#8
REVIEW
Debbie Spain, Jacqueline Sin, Eleni Paliokosta, Marie Furuta, Jonathan E Prunty, Trudie Chalder, Declan G Murphy, Francesca G Happé
BACKGROUND: Autism spectrum disorders (ASDs) are characterised by impairments in communication and reciprocal social interaction. These impairments can impact on relationships with family members, augment stress and frustration, and contribute to behaviours that can be described as challenging. Family members of individuals with ASD can experience high rates of carer stress and burden, and poor parental efficacy. While there is evidence to suggest that individuals with ASD and family members derive benefit from psychological interventions designed to reduce stress and mental health morbidity, and enhance coping, most studies to date have targeted the needs of either individuals with ASD, or family members...
May 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28507523/autism-spectrum-disorders-and-schizophrenia-spectrum-disorders-excitation-inhibition-imbalance-and-developmental-trajectories
#9
Roberto Canitano, Mauro Pallagrosi
Autism spectrum disorders (ASD) and schizophrenia spectrum disorders (SSD) share clinical and genetic components that have long been recognized. The two disorders co-occur more frequently than would be predicted by their respective prevalence, suggesting that a complex, multifactor association is involved. However, DSM-5 maintains the distinction between ASD, with core social and communication impairments, and SSD, including schizophrenia (SCZ), with hallucinations, delusions, and thought disorder as essential features...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28504353/cmip-haploinsufficiency-in-two-patients-with-autism-spectrum-disorder-and-co-occurring-gastrointestinal-issues
#10
Minjie Luo, Jinbo Fan, Tara L Wenger, Margaret H Harr, Melissa Racobaldo, Surabhi Mulchandani, Holly Dubbs, Elaine H Zackai, Nancy B Spinner, Laura K Conlin
Autism spectrum disorder (ASD) is a genetically heterogeneous group of disorders characterized by impairments in social communication and restricted interests. Though some patients with ASD have an identifiable genetic cause, the cause of most ASD remains elusive. Many ASD susceptibility loci have been identified through clinical studies. We report two patients with syndromic ASD and persistent gastrointestinal issues who carry de novo deletions involving the CMIP gene detected by genome-wide SNP microarray and fluorescence in situ hybridization (FISH) analysis...
May 15, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28502837/use-of-technology-to-facilitate-physical-activity-in-children-with-autism-spectrum-disorders-a-pilot-study
#11
Melissa D Bittner, B Rhett Rigby, Lisa Silliman-French, David L Nichols, Suzanna R Dillon
Deficits in social behavior and communication skills are correlated with reduced gross motor skills in children with autism spectrum disorders (ASD). The ExerciseBuddy application (EB app) was designed to communicate these motor skills to those with ASD and integrates evidence-based practices such as visual support and video modeling supported by The National Professional Development Center on Autism Spectrum Disorders. The purpose of this study was to determine the effectiveness of the EB app in facilitating increased physiologic responses to physical activity via a continuous measurement of energy expenditure and heart rate versus practice-style teaching methods in children with ASD...
May 11, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28501654/urinary-organophosphate-insecticide-metabolite-concentrations-during-pregnancy-and-children-s-interpersonal-communication-repetitive-and-stereotypic-behaviors-at-8-years-of-age-the-home-study
#12
Marisa E Millenson, Joseph M Braun, Antonia M Calafat, Dana Boyd Barr, Yen-Tsung Huang, Aimin Chen, Bruce P Lanphear, Kimberly Yolton
BACKGROUND: Prenatal exposure to organophosphate insecticides may be associated with autism spectrum disorders and related behaviors. This association may be modified by single nucleotide polymorphisms in the paraoxonase (PON1) enzyme. OBJECTIVE: We examined the relationship of prenatal organophosphate insecticide biomarkers with reciprocal social, repetitive, and stereotypic behaviors in 8-year old children, and modification of this relationship by child PON1 polymorphisms...
May 10, 2017: Environmental Research
https://www.readbyqxmd.com/read/28500650/aberrant-cognitive-phenotypes-and-altered-hippocampal-bdnf-expression-related-to-epigenetic-modifications-in-mice-lacking-the-post-synaptic-scaffolding-protein-shank1-implications-for-autism-spectrum-disorder
#13
A Özge Sungur, Magdalena C E Jochner, Hani Harb, Ayşe Kılıç, Holger Garn, Rainer K W Schwarting, Markus Wöhr
Autism spectrum disorder (ASD) is a class of neurodevelopmental disorders characterized by persistent deficits in social communication/interaction, together with restricted/repetitive patterns of behavior. ASD is among the most heritable neuropsychiatric conditions, and while available evidence points to a complex set of genetic factors, the SHANK gene family has emerged as one of the most promising candidates. Here, we assessed ASD-related phenotypes with particular emphasis on social behavior and cognition in Shank1 mouse mutants in comparison to heterozygous and wildtype littermate controls across development in both sexes...
May 12, 2017: Hippocampus
https://www.readbyqxmd.com/read/28499914/advances-in-understanding-the-pathophysiology-of-autism-spectrum-disorders
#14
REVIEW
Konstantin Yenkoyan, Artem Grigoryan, Katarine Fereshetyan, Diana Yepremyan
Autism spectrum disorders (ASD) are common heterogeneous neurodevelopmental disorders with typical triad of symptoms: impaired social interaction, language and communication abnormalities, and stereotypical behavior. Despite extensive research, the etiology and pathogenesis of ASD remain largely unclear. The lack of solid knowledge on the mechanisms of these disorders decreases the opportunities for pathogenetic treatment of autism. Various theories where proposed in order to explain the pathophysiology underlying ASD...
May 9, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28498053/autism-behavior-inventory-a-novel-tool-for-assessing-core-and-associated-symptoms-of-autism-spectrum-disorder
#15
Abi Bangerter, Seth Ness, Michael G Aman, Anna J Esbensen, Matthew S Goodwin, Geraldine Dawson, Robert Hendren, Bennett Leventhal, Anzalee Khan, Mark Opler, Adrianne Harris, Gahan Pandina
OBJECTIVE: Autism Behavior Inventory (ABI) is a new measure for assessing changes in core and associated symptoms of autism spectrum disorder (ASD) in participants (ages: 3 years-adulthood) diagnosed with ASD. It is a web-based tool with five domains (two ASD core domains: social communication, restrictive and repetitive behaviors; three associated domains: mental health, self-regulation, and challenging behavior). This study describes design, development, and initial psychometric properties of the ABI...
May 12, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28497358/predictive-value-of-selected-biomarkers-related-to-metabolism-and-oxidative-stress-in-children-with-autism-spectrum-disorder
#16
Afaf El-Ansary, Geir Bjørklund, Salvatore Chirumbolo, Osima M Alnakhli
Autism spectrum disorder (ASD) as a neurodevelopmental disorder is characterized by impairments in social interaction, communication, and restricted, repetitive behavior. Several and reproducible studies have suggested that oxidative stress may represent one of the primary etiological mechanism of ASD that can be targeted for therapeutic intervention. In the present study, multiple regression and combined receiver operating characteristic (ROC) analysis were used to search for a relationship between impaired energy and oxidative metabolic pathways in the etiology of ASD and to find the linear combination that maximizes the partial area under a ROC curve for a pre-identified set of markers related to energy metabolism and oxidative stress...
May 11, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28493759/-characterizing-autism-relevant-social-behavior-in-poodles-canis-familiaris-via-owner-report-correction-to-zamzow-et-al-2017
#17
(no author information available yet)
Reports an error in "Characterizing Autism-Relevant Social Behavior in Poodles via Owner Report" by Rachel M. Zamzow, Lisa Lit, Shelley Hamilton and David Q. Beversdorf (Journal of Comparative Psychology, Advanced Online Publication, Mar 13, 2017, np). In the article, the scientific name for the species was missing in the title. All versions of this article have been corrected. (The following abstract of the original article appeared in record 2017-11247-001.) Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social communication and the presence of restricted, repetitive behaviors...
May 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/28490882/connectivity-to-computers-and-the-internet-among-patients-with-schizophrenia-spectrum-disorders-a-cross-sectional-study
#18
Maritta Välimäki, Lauri Kuosmanen, Heli Hätönen, Marita Koivunen, Anneli Pitkänen, Christina Athanasopoulou, Minna Anttila
PURPOSE: Information and communication technologies have been developed for a variety of health care applications and user groups in the field of health care. This study examined the connectivity to computers and the Internet among patients with schizophrenia spectrum disorders (SSDs). PATIENTS AND METHODS: A cross-sectional survey design was used to study 311 adults with SSDs from the inpatient units of two psychiatric hospitals in Finland. The data collection lasted for 20 months and was done through patients' medical records and a self-reported, structured questionnaire...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28487267/embodied-conversational-agents-in-clinical-psychology-a-scoping-review
#19
Simon Provoost, Ho Ming Lau, Jeroen Ruwaard, Heleen Riper
BACKGROUND: Embodied conversational agents (ECAs) are computer-generated characters that simulate key properties of human face-to-face conversation, such as verbal and nonverbal behavior. In Internet-based eHealth interventions, ECAs may be used for the delivery of automated human support factors. OBJECTIVE: We aim to provide an overview of the technological and clinical possibilities, as well as the evidence base for ECA applications in clinical psychology, to inform health professionals about the activity in this field of research...
May 9, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28484884/neuropilin-2-rs849563-gene-variations-and-susceptibility-to-autism-in-iranian-population-a-case-control-study
#20
Marziyeh Hosseinpour, Farhad Mashayekhi, Elham Bidabadi, Zivar Salehi
Autism spectrum disorders (ASD) are neurodevelopmental disruptions usually diagnosed in the first three years of child's life that characterized by some impairments in verbal and nonverbal communication, problems in social interactions and repetitive behaviors. The neuropilin-2 (NRP2) gene has been shown to both guide axons and control neuronal migration in the central nervous system (CNS). In this study the association between the NRP2 gene and autism using a cohort of 120 Iranian children (50 cases with autism and 70 control cases) was analyzed...
May 8, 2017: Metabolic Brain Disease
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