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https://www.readbyqxmd.com/read/27899782/-trans-arterial-chemoembolization-therapy-for-giant-cholangiocellular-carcinoma-a-single-case-report
#1
Keita Yamashiro, Astushi Hori, Takeo Yuki, Ryosuke Ohira, Shinichi Hori
Here, we report a case of cholangiocellular carcinoma that was successfully treated with chemotherapy using a selective intra-arterial infusion technique. A 65-year-old man presented to our hospital to obtain a second opinion regarding his disease. The patient was diagnosed with cholangiocellular carcinoma. The giant tumor was located in the porta hepatis. Some small nodules that were considered to be metastatic lesions were also observed in the surroundingarea. The tumor was judged by the primary physician to be too large for surgical treatment...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27402527/an-in-vitro-evaluation-of-four-types-of-drug-eluting-microspheres-loaded-with-doxorubicin
#2
Thierry de Baere, Stephen Plotkin, Renee Yu, Allison Sutter, Yue Wu, Gregory M Cruise
PURPOSE: To compare in vitro properties of 4 drug-eluting embolic agents loaded with doxorubicin. MATERIALS AND METHODS: DC Bead (100-300 µm), LifePearl (200 µm), HepaSphere (30-60 µm), and Tandem (100 µm) microspheres were loaded with 40 mg/20 mL of doxorubicin per milliliter of microspheres. Loading, elution, diameter changes after loading, changes in the amount of doxorubicin loaded over 2 weeks in storage, and time in suspension were evaluated. RESULTS: All microspheres loaded > 99% doxorubicin within 1 hour...
September 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27264430/a-case-of-resected-hepatocellular-carcinoma-after-drug-eluting-bead-transarterial-chemoembolization
#3
Atsuyuki Ikeda, Yumiko Yasuhara, Daizen Hirata, Mari Teramura, Takeharu Nakamura, Yoko Oiwa, Osamu Araki, Hidemasa Azechi, Ryuta Nishitai, Hiroyuki Kokuryu
We report a case of resected hepatocellular carcinomas (HCCs) after drug-eluting bead transarterial chemoembolization (DEB-TACE). A 67-year-old man with alcoholic liver disease was diagnosed with HCCs. Serological markers for hepatitis B and C viruses were negative. Among tumor markers, alpha-fetoprotein was 2.7ng/mL, and protein induced by vitamin K absence II was 868mAU/mL. Two HCCs were detected using dynamic computed tomography: one was 9cm in diameter in S8 and the other was 2cm in diameter in S4. We performed DEB-TACE using HepaSphere(®) and epirubicin...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/26805186/-trans-arterial-chemoembolization-therapy-for-refractory-advanced-non-small-cell-lung-cancer-with-spherical-embolic-material-a-single-case-report
#4
Norifumi Kennoki, Shinichi Hori, Takeo Yuki, Satoshi Sueyoshi, Atsushi Hori
Here, we report the use of trans-arterial chemoembolization for primary lung cancer. The patient was a 56-year-old woman with refractory Stage Ⅳ non-small cell lung cancer who had been treated with repeated systemic chemotherapy. The primary lesion in the right lower lobe was 75 mm in size, with multiple lung metastases. It invaded the right main bronchus and caused severe cough. Radiotherapy was not indicated because of the size and extent of the lesion. During a period of 6 months, chemoembolization of the bilateral bronchial arteries using cisplatin 20 mg, docetaxel 20 mg, and 5-FU 250 mg with HepaSphere (super-absorbent polymer microspheres) was performed 5 times...
November 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/26321015/a-single-center-retrospective-comparison-of-doxorubicin-loaded-hepasphere-transarterial-chemoembolization-with-conventional-transarterial-chemoembolization-for-patients-with-unresectable-hepatocellular-carcinoma
#5
COMPARATIVE STUDY
Fahrettin Kucukay, Serife Badem, Adnan Karan, Mustafa Ozdemir, Riza S Okten, Nilgun I Ozbulbul, Murat B Kucukay, Ipek Unlu, Erdal B Bostanci, Meral Akdogan
PURPOSE: To compare doxorubicin-loaded HepaSphere transarterial chemoembolization versus conventional transarterial chemoembolization in terms of survival, time to recurrence, acute reversible hepatotoxicity, postembolization syndrome, and chemoembolization-related mortality and morbidity. MATERIALS AND METHODS: One hundred twenty-six patients (103 men, 23 women; mean age, 64.3 y) with unresectable hepatocellular carcinoma (HCC) who underwent conventional chemoembolization between January 2007 and March 2011 or drug-eluting embolic (DEE) chemoembolization (after the protocol change) between March 2011 and October 2014 were included in a retrospective analysis...
November 2015: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/26111877/transcatheter-arterial-embolization-of-hypervascular-tumors-with-hepasphere-prospective-multicenter-open-label-clinical-trial-of-microspheres-in-japan
#6
MULTICENTER STUDY
Takao Hiraki, Jun Koizumi, Yasuaki Arai, Yasuo Sakurai, Hiromitsu Kumada, Yoshihiro Nambu, Shinichi Hori
PURPOSE: To evaluate the feasibility and safety of transcatheter arterial embolization (TAE) with the use of HepaSphere microspheres for hypervascular tumors. MATERIALS AND METHODS: This was a prospective multicenter open label clinical trial involving six institutions in Japan. TAE was performed with the HepaSphere microspheres for hypervascular tumors in various locations. The endpoint of the study was the feasibility and safety of the procedure. The feasibility and safety were evaluated according to technical success and adverse events, respectively...
August 2015: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/25952641/safety-and-efficacy-compared-between-irinotecan-loaded-microspheres-hepasphere-and-dc-bead-in-a-model-of-vx2-liver-metastases-in-the-rabbit
#7
COMPARATIVE STUDY
Julien Namur, Florentina Pascale, Noboru Maeda, Manon Sterba, Saida Homayra Ghegediban, Valentin Verret, Angelo Paci, Atmane Seck, Keigo Osuga, Michel Wassef, Philippe Reb, Alexandre Laurent
PURPOSE: To compare irinotecan-eluting HepaSphere (BioSphere Medical, Roissy-en-France, France) and DC Bead (Biocompatibles UK Ltd, London, United Kingdom) embolization microspheres for distribution in tumors, release properties, tolerance, and antitumor effects in a model of liver metastases in the rabbit. MATERIALS AND METHODS: Multiple liver tumors were created by injection of a VX2 cell suspension in the portal vein of rabbits. After 2 weeks, embolization of the proper hepatic artery was performed with a fixed volume of bland HepaSphere (n = 5), irinotecan-loaded HepaSphere (n = 6), or irinotecan-loaded DC Bead (n = 5) microspheres...
July 2015: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/25937772/transcatheter-embolization-therapy-in-liver-cancer-an-update-of-clinical-evidences
#8
REVIEW
Yì-Xiáng J Wáng, Thierry De Baere, Jean-Marc Idée, Sébastien Ballet
Transarterial chemoembolization (TACE) is a form of intra-arterial catheter-based chemotherapy that selectively delivers high doses of cytotoxic drug to the tumor bed combining with the effect of ischemic necrosis induced by arterial embolization. Chemoembolization and radioembolization are at the core of the treatment of liver hepatocellular carcinoma (HCC) patients who cannot receive potentially curative therapies such as transplantation, resection or percutaneous ablation. TACE for liver cancer has been proven to be useful in local tumor control, to prevent tumor progression, prolong patients' life and control patient symptoms...
April 2015: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/24263774/chemoembolization-of-hepatocellular-carcinoma-with-hepasphere-30-60-%C3%AE-m-safety-and-efficacy-study
#9
Katerina Malagari, Maria Pomoni, Hippokratis Moschouris, Alexios Kelekis, Angelos Charokopakis, Evanthia Bouma, Themistoklis Spyridopoulos, Achilles Chatziioannou, Vlasios Sotirchos, Theodoros Karampelas, Constantin Tamvakopoulos, Dimitrios Filippiadis, Enangelos Karagiannis, Athanasios Marinis, John Koskinas, Dimitrios A Kelekis
BACKGROUND: This study examined the safety, pharmacokinetics, and efficacy of transarterial chemoembolization of hepatocellular carcinoma (HCC) using a newly developed size of a superabsorbent polymer drug-eluting embolic material. METHODS: Forty-five patients with documented HCC (Child-Pugh score A/B: 55.5 %/44.5 %) were embolized with HepaSphere microspheres 30-60 μm with escalation of lesion, dose, and frequency of re-embolization. Local response was evaluated with modified response evaluation criteria in solid tumors (mRECIST)...
February 2014: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/23670568/transcatheter-arterial-chemoembolization-tace-of-colorectal-cancer-liver-metastases-by-irinotecan-eluting-microspheres-in-a-salvage-patient-population
#10
Peter Huppert, Thorsten Wenzel, Hubertus Wietholtz
PURPOSE: This prospective study evaluated the effectiveness and safety of TACE using irinotecan loaded superabsorbent polymer (SAP) microspheres for treatment of colorectal cancer liver metastases (CCLM) in a salvage setting of patients. METHODS: A total of 71 TACE procedures were performed in 29 patients with liver only or liver-dominant CCLM. In all patients, systemic chemotherapy before TACE had failed. Two hundred milligrams of irinotecan were loaded into 50-100 mg of SAP microspheres (HepaSphere™ Microspheres) considering tumor size and vascularization...
February 2014: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/23337906/simultaneous-measurement-of-doxorubicin-and-reduced-metabolite-doxorubicinol-by-uhplc-ms-ms-in-human-plasma-of-hcc-patients-treated-with-tace
#11
Cristina Sottani, Guido Poggi, Fabio Melchiorre, Benedetta Montagna, Claudio Minoia
A sensitive, selective, accurate and precise method for simultaneous quantification of doxorubicin (DOX) and doxorubicinol (DOXol) in human plasma of patients diagnosed as having intermediate stage unresectable hepatocellular carcinoma (HCC) was developed. The method was based on electrospray tandem mass spectrometry in selected reaction monitoring mode. DOX, DOXol and trofosfamide, an internal standard, were extracted from plasma by using a simple solid phase extraction (SPE) procedure after the addition of 0...
February 1, 2013: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/22802838/drug-eluting-microspheres-transarterial-chemoembolization-dem-tace-in-patients-with-liver-metastases-pilot-study
#12
Magdalena Jarząbek, Tomasz Jargiełło, Andrzej Wolski, Paweł Poluha, Małgorzata Szczerbo-Trojanowska
BACKGROUND: Only 10 to 20% of patients with hepatic metastases qualify for radical resection of their lesions. The treatment issue among the rest of patients is a small clinical response to overall chemiotherapy and the frequent inability to treat patients with percutaneous thermoablation. In the latter circumstance, parallel to the radical surgery, the reason is the size of the lesion or lack of access to it. MATERIAL/METHODS: 15 patients with hepatic metastases, who had been rejected from consideration of radical resection and thermoablation were subjected to chemoembolization of the proper hepatic artery branches...
July 2011: Polish Journal of Radiology
https://www.readbyqxmd.com/read/22593459/serum-pharmacokinetics-in-patients-treated-with-transarterial-chemoembolization-tace-using-two-types-of-epirubicin-loaded-microspheres
#13
Cristina Sottani, Guido Poggi, Pietro Quaretti, Mario Regazzi, Benedetta Montagna, Erica Quaquarini, Marcello Imbriani, Emanuela Leoni, Pamela Di Cesare, Alberto Riccardi, Giovanni Bernardo, Claudio Minoia
AIM: The purpose of this study was the pharmacokinetic (PK) profile assessment in the serum of patients affected by hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) with drug-eluting beads. PATIENTS AND METHODS: This study included 20 patients, 12 treated with DC Bead® and 8 with HepaSphere Microsphere®, preloaded with epirubicin. No patient randomization was used for the inclusion in one group or in the other. Peripheral blood samples were obtained from all patients after the treatment, until 24 hours past the procedure...
May 2012: Anticancer Research
https://www.readbyqxmd.com/read/21067940/trans-arterial-chemoembolization-as-a-therapy-for-liver-tumours-new-clinical-developments-and-suggestions-for-combination-with-angiogenesis-inhibitors
#14
REVIEW
C Damiano Gadaleta, Girolamo Ranieri
The liver is the primary site of metastases for many malignancies. Gastrointestinal cancers are especially prone to spread to the liver and other tumours, as breast cancer and melanoma often spread to the liver. On the other hand, hepatocellular cancer (HCC) is the fifth most common malignancy in the world due to its common etiology from chronic liver damage caused by hepatitis or cirrhosis. Treatments of liver tumours vary according to histology and liver invasion and until now trans-arterial chemoembolization (TACE) has represented a main approach in the therapy of liver tumours...
October 2011: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/20821211/transcatheter-arterial-chemoembolization-with-epirubicin-loaded-superabsorbent-polymer-microspheres-for-135-hepatocellular-carcinoma-patients-single-center-experience
#15
Akihiko Seki, Shinich Hori, Kazuya Kobayashi, Seizi Narumiya
PURPOSE: To evaluate the safety, clinical outcomes, and hepatic artery damage after transcatheter arterial chemoembolization (TACE) with epirubicin-loaded superabsorbent polymer microspheres (ELM-TACE) in patients with hepatocellular carcinoma (HCC) in a single center in Japan. MATERIALS AND METHODS: This embolic agent is the original form of microspheres, which has the same composition and nature as HepaSpheres. Between May 2007 and June 2009, 135 patients with unresectable HCC who underwent ELM-TACE were enrolled...
June 2011: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/20610183/comparative-study-of-chemoembolization-loadable-beads-in-vitro-drug-release-and-physical-properties-of-dc-bead-and-hepasphere-loaded-with-doxorubicin-and-irinotecan
#16
COMPARATIVE STUDY
Olivier Jordan, Alban Denys, Thierry De Baere, Nathalie Boulens, Eric Doelker
PURPOSE: To characterize in vitro the loadability, physical properties, and release of irinotecan and doxorubicin from two commercially available embolization microspheres. MATERIALS AND METHODS: DC Bead (500-700 microm) and Hepasphere (400-600 microm) microspheres were loaded with either doxorubicin or irinotecan solutions. Drug amount was quantified with spectrophotometry, bead elasticity was measured under compression, and bead size and loading homogeneity were assessed with microscopy image analysis...
July 2010: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/19803201/-embolization-of-high-flow-arteriovenous-malformations-with-hepasphere-microspheres
#17
Yu-Qing Du, S Hori, Wei-Zhong Zhou, Yong-E Liu
OBJECTIVE: To determine the effect, safety, and feasibility of embolization of high flow arteriovenous malformations (AVMs) with HepaSphere microspheres. METHODS: HepaSphere particles swell by absorbing fluids and become soft and deformable with a precisely calibrated diameter. 13 patients with AVMs were treated by transarterial embolization with HepaSphere particles. 3 cases underwent a following AVMs resection surgery. The follow-up period was 3 months to 3 years...
May 2009: Zhonghua Zheng Xing Wai Ke za Zhi, Zhonghua Zhengxing Waike Zazhi, Chinese Journal of Plastic Surgery
https://www.readbyqxmd.com/read/19192637/transhepatic-arterial-chemoembolization-with-oxaliplatin-eluting-microspheres-oem-tace-for-unresectable-hepatic-tumors
#18
Guido Poggi, Pietro Quaretti, Claudio Minoia, Giovanni Bernardo, Mario Regazzi Bonora, Raffaella Gaggeri, Anna Ronchi, Cesare Massa Saluzzo, Andrea Azzaretti, Giuseppe Rodolico, Michela Montagna, Alessio Amatu, Cristina Teragni, Ilaria Palumbo, Elena Traverso, Stefano Tonini, Laura Villani, Mario Scelsi, Paola Baiardi, Maria Grazia Felisi, Federico Sottotetti, Barbara Tagliaferri, Alberto Riccardi
BACKGROUND: While conventional transhepatic arterial chemoembolization (TACE) is accepted worldwide as an effective treatment for patients with unresectable hepatocellular carcinoma (HCC), its use in other hepatic tumors is not supported by randomized studies. Preliminary results have shown that new drug-eluting microspheres (DEM) seem to optimize TACE procedures. The aim of this study was to evaluate the capability of HepaSphere to load oxaliplatin and their pharmacokinetic outcome. The feasibility and safety of treatment with oxaliplatin-eluting microspheres (OEM-TACE) was also evaluated in patients with unresectable liver metastasis of colorectal cancer and unresectable intrahepatic cholangiocarcinoma...
November 2008: Anticancer Research
https://www.readbyqxmd.com/read/18823795/comparative-study-of-four-different-spherical-embolic-particles-in-an-animal-model-a-morphologic-and-histologic-evaluation
#19
COMPARATIVE STUDY
José I Bilbao, Esther de Luis, José A García de Jalón, Alba de Martino, María D Lozano, Antonio Martínez de la Cuesta, Bruno Sangro
PURPOSE: To perform a study in a porcine model comparing four different spherical embolic particles in terms of postembolization patency, deformation, and potential for recanalization, with a focus on a relatively new agent--HepaSphere. MATERIALS AND METHODS: Partial embolization of both kidneys was performed in 18 pigs. Nine animals were sacrificed at 48 hours and nine at 4 weeks. In the same animal, the right kidney was embolized with HepaSphere particles ("dry" size, 50-100 microm; presumed final size, 200-300 microm), and the left kidney was alternatively embolized with EmboSphere (100-300 microm), Contour (150-350 microm), or Bead Block (150-350 microm) particles...
November 2008: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/18696150/transarterial-chemoembolization-for-hepatocellular-carcinoma-with-drug-eluting-microspheres-preliminary-results-from-an-italian-multicentre-study
#20
MULTICENTER STUDY
Maurizio Grosso, Claudio Vignali, Pietro Quaretti, Antonio Nicolini, Fabio Melchiorre, Gabriele Gallarato, Irene Bargellini, Pasquale Petruzzi, Cesare Massa Saluzzo, Silvia Crespi, Ilaria Sarti
The purpose of this article is to present the early results of a multicentre trial using HepaSphere microspheres loaded with chemotherapeutic agents for transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma. From December 2005 to March 2007, 50 patients (36 male and 14 female, mean age 68.4 years) were treated by selective TACE using HepaSphere microspheres loaded with doxorubicin or epirubicin. The diameter of the treated lesions ranged from 20 to 100 mm (mean 42.5; maximum of 4 tumor nodules)...
November 2008: Cardiovascular and Interventional Radiology
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