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Camyla Alves Leonel, William Gustavo Lima, Michelli Dos Santos, Ariane Coelho Ferraz, Alex Gutterres Taranto, José Carlos de Magalhães, Luciana Lara Dos Santos, Jaqueline Maria Siqueira Ferreira
Dengue virus (DENV) infection can lead to a wide range of clinical manifestations, including fatal hemorrhagic complications. There is a need to find effective pharmacotherapies to treat this disease due to the lack of specific immunotherapies and antiviral drugs. That said, the DENV NS2B/NS3pro protease complex is essential in both the viral multiplication cycle and in disease pathogenesis, and is considered a promising target for new antiviral therapies. Here, we performed a systematic review to evaluate the pharmacophoric characteristics of promising compounds against NS2B/NS3pro reported in the past 10 years...
November 16, 2017: Archives of Virology
Hussein M Ali, Isra H Ali
Antioxidant activity of anthocyanidins is greatly affected by the 3-hydroxyl group and/or a catecholic moiety. The two-hydrogen atom donation process is frequently used to explain the high antioxidant activity of polyphenolic compounds leading to the formation of stable diketones e.g. 1,2-quinones. Thermodynamic parameters, HOMO and spin density were computed to identify the favoured path, either through the 3-hydroxyl group or through the catecholic moiety in a series of catecholic and non-catecholic 3-oxy- (and deoxy)-anthocyanidins...
March 15, 2018: Food Chemistry
Leilani B Mercado-Asis, Katherine I Wolf, Ivana Jochmanova, David Taïeb
OBJECTIVE: Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumors derived from adrenal or extra-adrenal locations, respectively. Upon suspicion of PPGL, specific metabolomic, molecular, biochemical, imaging, and histopathological studies are performed to prove, localize, treat, and monitor disease progression. Recently, improved diagnostic tools allow physicians to accurately diagnose PPGL, even in patients presenting with small (less than 1 cm) or biochemically silent tumors, which previously delayed proper detection and treatment...
November 16, 2017: Endocrine Practice
Baolin Hou, Renjian Deng, Bozhi Ren, Zhi Li
A novel type of catalytic particle electrode (SAC-Fe) was developed from sewage sludge and iron sludge via a facile method. The catalytic particle electrodes (CPEs) were also supposed to be heterogeneous catalyst for electro-Fenton (EF). The CPEs were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). SAC-Fe showed superior porous structure and higher adsorption capacity and catalytic activity than Fe3O4 magnetic nanoparticles. Catechol and total organic carbon (TOC) removal efficiency can reach 96...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Xueting Li, Jia Yu, Jianan Li, Yanping Wu, Baixiang Li
Many studies have shown that the pollutant simazine (6-chloro-N,N'-diethyl-1,3,5-triazine-2,4-diamine), which has been overused, inhibits the proliferation of mammalian dopaminergic cells, and affects the developmental differentiation of mammalian dopaminergic neurons. However, few studies have shown the effects of simazine on dopaminergic metabolism in these cells. Therefore, we aim to examine the metabolic effects of simazine exposure in mouse dopaminergic progenitor neurons (MN9D) at different exposure times...
November 13, 2017: International Journal of Molecular Sciences
Shanxia Jin, Wei Zhang, Qin Yang, Lili Dai, Ping Zhou
In this work, inorganic boronate affinity monolith was prepared by in situ synthesis in 0.33mm i.d. stainless steel needle through sol-gel process using tetraethoxysilane and tetrabutyl orthotitanate as the co-precursors. The morphology, structure and composition of the monolith were characterized. In contrast to conventional boronate affinity materials, inorganic boric acid was used as affinity ligand. Different compounds were used for the evaluation of the boronate affinity of this inorganic monolithic material...
February 1, 2018: Talanta
Parker J Smith, John C Goeltz
The 1,2-diol moiety in a variety of substituted catechols allows formation of room temperature ionic melts in a 2:1 ratio with choline chloride or choline dihydrogen citrate. These deep eutectic solvents were 4.3-6.6 M in redox active catechols. Substituents on 3- and 4-substituted catechols shift both E° and pKa such that Hammett parameters predict the observed Ep for oxidation in square wave voltammetry. The proton acceptor for the proton-coupled oxidation shifts the observed Ep more strongly than the substituents within the substituents and acceptors reported here...
November 13, 2017: Journal of Physical Chemistry. B
Rong Lu, Takayuki Honda, Meesook Sung, Jaekook Jung, Tetsuo Miyakoshi
The chemical structure of fresh lacquer sap collected from a lacquer tree growing in Nago City of Okinawa, Japan, was analyzed by gas chromatography/mass-spectrometry (GC/MS) and nuclear magnetic resonance (NMR). The results showed that Nago lacquer is laccol lacquer and its major components are 3-(heptadeca-10Z,13E,15E-trienyl)catechol, 3-(heptadeca-10Z,13E-dienyl)catechol, 3-(heptadeca-14Z-enyl)catechol, and 3-(heptadeca-12Z-enyl)catechol, which are similar to the components of Vietnamese lacquer. It showed higher laccase activity at pH 5 - 8 and better low temperature adaptability than Vietnamese lacquer...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Sheila Leone, Lucia Recinella, Annalisa Chiavaroli, Sara Martinotti, Claudio Ferrante, Adriano Mollica, Giorgia Macedonio, Azzurra Stefanucci, Szabolcs Dvorácskó, Csaba Tömböly, Luciano De Petrocellis, Michele Vacca, Luigi Brunetti, Giustino Orlando
BACKGROUND: The endocannabinoid (eCB) system plays an important role in regulating emotional disorders, and is involved, directly or indirectly, in psychiatric diseases, such as anxiety and depression. Hemopressin, a hemoglobin α chain-derived peptide, and RVD-hemopressin(α), a N-terminally extended form of hemopressin, act as antagonist/inverse agonist and negative allosteric modulator of the cannabinoid 1 (CB1) receptor, respectively. METHODS: Considering the possible involvement of these peptides on emotional behaviour, the aim of our study was to investigate the behavioural effects of a single intraperitoneal (ip) injection of hemopressin (0...
June 23, 2017: Pharmacological Reports: PR
Lingyi Huang, Dejan Nikolic, Richard B van Breemen
The metabolism of the chemoprevention agent licochalcone A, which is a chemopreventive chalcone found in abundance in the licorice species Glycyrrhiza inflata, was investigated using human liver microsomes and human hepatocytes combined with analysis using high performance liquid chromatography-mass spectrometry (LC-MS). Five oxygenated phase I metabolites of licochalcone A were formed by human liver microsomes, including a catechol on the A-ring, two intramolecular cyclization products following epoxidation of the exocyclic alkene at position 5 of the B-ring, and two dioxygenated products...
November 10, 2017: Analytical and Bioanalytical Chemistry
Ameya R Narkar, Jonathan D Kelley, Rattapol Pinnaratip, Bruce P Lee
Adhesive hydrogels were prepared by copolymerizing dopamine methacrylamide (DMA) with either acrylic acid (AAc) or N-(3-aminopropyl)methacrylamide hydrochloride (APMH). The effect of incorporating the anionic and cationic side chains on the oxidation state of catechol was characterized using the FOX assay to track the production of hydrogen peroxide (H2O2) byproduct generated during the autoxidation of catechol while the interfacial binding property of the adhesive was determined by performing Johnson-Kendall-Roberts (JKR) contact mechanics tests tested over a wide range of pH values (pH 3-9)...
November 10, 2017: Biomacromolecules
Franziska Roth-Walter, Luis F Pacios, Rodolfo Bianchini, Erika Jensen-Jarolim
Atopic individuals tend to develop a Th2 dominant immune response, resulting in hyperresponsiveness to harmless antigens, termed allergens. In the last decade, epidemiological studies have emerged that connected allergy with a deficient iron-status. Immune activation under iron-deficient conditions results in the expansion of Th2-, but not Th1 cells, can induce class-switching in B-cells and hampers the proper activation of M2, but not M1 macrophages. Moreover, many allergens, in particular with the lipocalin and lipocalin-like folds, seem to be capable of binding iron indirectly via siderophores harboring catechol moieties...
November 9, 2017: Metallomics: Integrated Biometal Science
Manuel Nieto Dominguez, Laura I de Eugenio, Pablo Peñalver, Efres Belmonte-Reche, Juan C Morales, Ana Poveda, Jesús Jiménez-Barbero, Alicia Prieto, Francisco J Plou, María Jesús Martínez
The eco-friendly synthesis of non-natural glycosides from different phenolic antioxidants was carried out using a fungal β-xylosidase in order to evaluate changes in their bioactivities. Xylosides from hydroquinone and catechol were successfully formed although the best results were obtained for hydroxytyrosol, the main antioxidant from olive oil. The formation of the new products was followed by thin layer chromatography, liquid chromatography and mass spectrometry. The hydroxytyrosyl xyloside was analyzed in more detail, in order to maximize its production and evaluate the effect of glycosylation on some hydroxytyrosol properties...
November 9, 2017: Journal of Agricultural and Food Chemistry
Katherine L Orchard, Daisuke Hojo, Katarzyna P Sokol, Meng-Ju Chan, Naoki Asao, Tadafumi Adschiri, Erwin Reisner
Visible-light driven H2 evolution in water is achieved using catechol-photosensitised TiO2 nanoparticles with a molecular nickel catalyst. Layer-by-layer immobilisation of catechol-TiO2 onto tin-doped indium oxide electrodes generates photocathodic currents in the presence of an electron acceptor. This approach represents a new strategy for controlling photocurrent direction in dye-sensitised photoelectrochemical applications.
November 9, 2017: Chemical Communications: Chem Comm
Di Jiang, Spundana Malla, You-Jun Fu, Dharamainder Choudhary, James F Rusling
Oxidation of DNA by reactive oxygen species (ROS) yields 8-oxo-7,8-dihydroguanosine (8-oxodG) as primary oxidation product, which can lead to downstream G to T transversion mutations. DNA mutations are nonrandom and mutations at specific codons are associated with specific cancers, as widely documented for the p53 tumor suppressor gene. Here, we present the first direct LC-MS/MS study of primary oxidation sites of p53 exon 7. We oxidized a 32 base pair (bp) double-stranded (ds) oligonucleotide representing exon 7 of the p53 gene...
November 8, 2017: Analytical Chemistry
Xueting Li, Jia Yu, Yanping Wu, Baixiang Li
The herbicide simazine is widely used in agricultural and non-agricultural fields. Studies have shown that simazine inhibits the proliferation of dopaminergic cells and affects the developmental differentiation of dopamine neurons. However, little is known about the effects of simazine on dopaminergic metabolism. Therefore, the present study examined the effects of simazine on Sprague‑Dawley (SD) rats from weaning to puberty (40 days exposure). Simazine was administered orally to SD rats at doses of 0, 12...
October 20, 2017: International Journal of Molecular Medicine
Zhiwen Zeng, Xiumei Mo
In this paper, a novel chitosan derivative, thiol-grafting bio-inspired catechol-conjugated chitosan was synthesized. The chemical structure of the synthesized catechol-conjugated chitosan was verified by (1)H NMR, and its contents of thiol group and catechol group were determined by UV-vis spectrum. Four percent of catechol-conjugated chitosan aqueous solution could form hydrogels rapidly in situ in 1 min or less with the addition of sodium periodate. Rheological studies showed that the mechanical properties depend on the concentrations of catechol-conjugated chitosan and the molar ratio of sodium periodate to catechol groups...
November 2017: Journal of Biomaterials Applications
Do Hyun Kang, Ho-Sup Jung, Keesung Kim, Jinsang Kim
Most solid-state biosensor platforms require a specific immobilization chemistry and a bioconjugation strategy separately to tether sensory molecules to a substrate and attach specific receptors to the sensory unit, respectively. We developed a mussel-inspired universal conjugation method that enables both surface immobilization and bioconjugation at the same time. By incorporating dopamine or catechol moiety into self-signaling polydiacetylene (PDA) liposomes, we demonstrated efficient immobilization of the PDA liposomes to a wide range of substrates, without any substrate modification...
November 17, 2017: ACS Applied Materials & Interfaces
Andrea Amato, Luisa Maria Migneco, Andrea Martinelli, Loris Pietrelli, Antonella Piozzi, Iolanda Francolini
Protein mussel-inspired adhesive polymers, characterized by the presence of catechol groups, possess superior muco-adhesive properties and have great potentiality in wound healing. Suitable materials for wound dressing should properly combine muco-adhesiveness and antimicrobial activity. In this work, catechol-functionalized chitosan was obtained by reaction with hydrocaffeic acid (HCAF), in order to investigate how catechol introduction at different content could affect the intrinsic antimicrobial activity of the polymer itself...
January 1, 2018: Carbohydrate Polymers
Rattapol Pinnaratip, Hao Meng, Rupak Rajachar, Bruce P Lee
A composite adhesive capable of inducing cellular infiltration was prepared by incorporating control clustered silica microparticle (MP) derived from the aggregation of silica nanoparticle (NP) into a catechol-terminated poly(ethylene glycol) bioadhesive (PEG-DA). Incorporation of MP into PEG-DA significantly improved the mechanical and adhesive properties of the bioadhesive. There was no statistical difference between the measured values for NP- and MP-incorporated adhesives, indicating that MP was equally as effective in enhancing the material properties of PEG-DA as NP...
November 6, 2017: Biomedical Materials
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