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https://www.readbyqxmd.com/read/28630796/von-hippel-lindau-disease-the-importance-of-retinal-hemangioblastomas-in-diagnosis
#1
Sevinç Şahin Atik, Aslı Ece Solmaz, Zafer Öztaş, Emine Deniz Eğrilmez, Şeyda Uğurlu, Tahir Atik, Filiz Afrashi
Von Hippel-Lindau (VHL) disease is a familial cancer syndrome characterized by benign or malignant tumors which may involve more than one system. Retinal hemangioblastomas are usually the initial manifestation of VHL disease and can cause vision loss. A 32-year-old man presented to our clinic with vision loss in the left eye for 2 months. He had a history of cerebral hemangioblastoma operation. Family history showed that his mother had unilateral vision loss and died because of renal cell carcinoma. Ophthalmologic examination revealed multiple retinal hemangioblastomas in both eyes...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28629787/oral-cancer-from-the-perspective-of-wide-field-optical-fluorescence-diagnosis-tumor-evolution-and-post-treatment-follow-up
#2
Sérgio Araújo Andrade, Sebastião Pratavieira, Marisa Maria Ribeiro, Vanderlei S Bagnato, Fernando de Pilla Varotti
In this communication, we present that wide-field optical fluorescence might be useful for: the screening of oral lesions that are imperceptible to the naked eye, determination of biopsy area, better definition of treatment, and previous and post-treatment follow-up.
June 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28627551/gold-loaded-nanoporous-iron-oxide-nanocubes-a-novel-dispersible-capture-agent-for-tumor-associated-autoantibody-analysis-in-serum
#3
Sharda Yadav, Mostafa Kamal Masud, Md Nazmul Islam, Vinod Gopalan, Alfred King-Yin Lam, Shunsuke Tanaka, Nam-Trung Nguyen, Md Shahriar Al Hossain, Cuiling Li, Md Yusuke Yamauchi, Muhammad J A Shiddiky
Autoantibodies are produced against tumor associated antigens (TAAs) long before the appearance of any symptoms and thus can serve as promising, non-invasive biomarkers for early diagnosis of cancer. Current conventional methods for autoantibody detection are highly invasive and mostly provide diagnosis in the later stages of cancer. Herein we report a new electrochemical method for early detection of p53 autoantibodies against colon cancer using a strategy that combines the strength of gold-loaded nanoporous iron oxide nanocube (Au@NPFe2O3NC)-based capture and purification while incorporating the inherent simplicity, inexpensive, and portable nature of the electrochemical and naked-eye colorimetric readouts...
June 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28625971/peripheral-leptochoroid-clinical-and-anatomical-findings
#4
Jasmine H Francis, Larissa A Habib, David H Abramson
BACKGROUND/AIMS: To investigate the clinical findings and anatomical characteristics of patients with a thinned peripheral choroid (leptochoroid) presenting with bilateral macular geographical hyperpigmented fundus and compare with matched controls. METHODS: A retrospective, observational case series of 44 eyes (24 patients): 22 study eyes (12 study patients) with clinical findings of leptochoroid (geographical hyperpigmented fundus centred in the macula) matched with 22 control eyes (12 control patients)...
June 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28621684/expression-of-hypothalamic-neurohormones-and-their-receptors-in-the-human-eye
#5
Sander R Dubovy, Maria P Fernandez, Jose J Echegaray, Norman L Block, Noriyuki Unoki, Roberto Perez, Irving Vidaurre, Richard K Lee, Mehrdad Nadji, Andrew V Schally
Extrapituitary roles for hypothalamic neurohormones have recently become apparent and clinically relevant, based on the use of synthetic peptide analogs for the treatment of multiple conditions including cancers, pulmonary edema and myocardial infarction. In the eye, it has been suggested that some of these hormones and their receptors may be present in the ciliary body, iris, trabecular meshwork and retina, but their physiological role has yet to be elucidated. Our study intends to comprehensively demonstrate the expression of some hypothalamic neuroendocrine hormones and their receptors within different retinal and extraretinal structures of the human eye...
June 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28620731/retinoblastoma
#6
Raksha Rao, Santosh G Honavar
Retinoblastoma represents 3% of all childhood cancers, and is the most common intraocular malignancy of childhood. It is fatal, if untreated. White eye reflex, also known as leukocoria, is the commonest sign, followed by strabismus. The pediatricians have a very important role to play in the diagnosis of this relatively rare, but easily detectable tumor. Early diagnosis yields better results. The management of retinoblastoma has gradually evolved over the past few decades, with an aim to not only preserve life and eye, but also optimize residual vision...
June 16, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28618918/does-guiding-toward-task-relevant-information-help-improve-graph-processing-and-graph-comprehension-of-individuals-with-low-or-high-numeracy-an-eye-tracker-experiment
#7
Carmen Keller, Alex Junghans
BACKGROUND: Individuals with low numeracy have difficulties with understanding complex graphs. Combining the information-processing approach to numeracy with graph comprehension and information-reduction theories, we examined whether high numerates' better comprehension might be explained by their closer attention to task-relevant graphical elements, from which they would expect numerical information to understand the graph. Furthermore, we investigated whether participants could be trained in improving their attention to task-relevant information and graph comprehension...
June 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28616898/smoking-and-the-eye-what-qu%C3%A3-bec-teenagers-know-and-fear
#8
Julie Brûlé, Benoît Tousignant, Stéphanie Marcotte, Marie-Christelle Moreau
BACKGROUND: Although most people associate smoking with lung cancer and heart disease, few are aware of the impact of smoking on ocular health. Studies have suggested a better knowledge of this association might promote higher quit rates, particularly in teenagers. The purpose of our study was to determine the knowledge of teenagers about the effects of smoking on ocular health and the fear associated with several tobacco-related health conditions. METHODS: A self-administered questionnaire was distributed to 180 high school students aged 14 to 17 years...
June 14, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28616133/naked-eye-detection-of-multiple-tumor-related-mrnas-from-patients-with-photonic-crystal-micropattern-supported-dual-modal-upconversion-bioprobes
#9
Xiaoxia Hu, Yingqian Wang, Haoyang Liu, Jie Wang, Yaning Tan, Fubing Wang, Quan Yuan, Weihong Tan
Development of a portable device for the detection of multiple mRNAs is a significant need in the early diagnosis of cancer. We have designed a biochip-based mRNA detection device by combining a hydrophilic-hydrophobic micropattern with upconversion luminescence (UCL) probes. The device achieves highly sensitive detection, using the naked eye, of multiple mRNAs among patient samples. The high sensitivity is attributed to enrichment of the target concentration and a fluorescence enhancement effect. In addition, since the photonic crystal (PC) dot biochip is functionalized with dual-wavelength excitation UCL probes, two kinds of mRNAs in the heterogeneous biological samples are detected simultaneously, and the corresponding luminescence signals are captured using an unmodified camera phone...
January 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28615677/associations-between-radiologist-defined-semantic-and-automatically-computed-radiomic-features-in-non-small-cell-lung-cancer
#10
Stephen S F Yip, Ying Liu, Chintan Parmar, Qian Li, Shichang Liu, Fangyuan Qu, Zhaoxiang Ye, Robert J Gillies, Hugo J W L Aerts
Tumor phenotypes captured in computed tomography (CT) images can be described qualitatively and quantitatively using radiologist-defined "semantic" and computer-derived "radiomic" features, respectively. While both types of features have shown to be promising predictors of prognosis, the association between these groups of features remains unclear. We investigated the associations between semantic and radiomic features in CT images of 258 non-small cell lung adenocarcinomas. The tumor imaging phenotypes were described using 9 qualitative semantic features that were scored by radiologists, and 57 quantitative radiomic features that were automatically calculated using mathematical algorithms...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28597076/juxtapapillary-and-circumpapillary-choroidal-melanoma-globe-sparing-treatment-outcomes-with-iodine-125-notched-plaque-brachytherapy
#11
John V Hegde, Tara A McCannel, Colin A McCannel, James Lamb, Pin-Chieh Wang, Darlene Veruttipong, Robert Almanzor, D Jeffrey Demanes, Mitchell Kamrava
PURPOSE: Managing juxtapapillary and circumpapillary choroidal melanoma with brachytherapy is challenging because of technical complications with accurate plaque placement and high radiation toxicity given tumor proximity to the optic nerve. We evaluated our center's experience using ultrasound-guided, Iodine (I)-125 notched plaque brachytherapy for treating choroidal melanoma contiguous with (juxtapapillary) and at least partially surrounding the optic disc (circumpapillary). METHODS: All cases of choroidal melanoma treated with I-125 notched plaque brachytherapy at our center from September 2003-December 2013 were retrospectively reviewed...
June 9, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28594699/solitary-iris-plasmacytoma-with-anterior-chamber-crystalline-deposits
#12
Andrew W Stacey, Alenka Lavric, Caroline Thaung, Samreen Siddiq, Mandeep S Sagoo
PURPOSE: To report a case of solitary iris plasmacytoma successfully treated with ruthenium plaque radiotherapy. METHODS: A 44-year-old white woman presented with pain in the right eye and raised intraocular pressure. Her medical history included breast cancer treated 11 years earlier with lumpectomy, lymph node clearance, chemotherapy, and radiotherapy. On examination, the right iris had a tan-colored mass with crystalline deposits visible on the mass surface and on the corneal endothelium...
July 2017: Cornea
https://www.readbyqxmd.com/read/28588112/the-hoorn-diabetes-care-system-dcs-cohort-a-prospective-cohort-of-persons-with-type-2-diabetes-treated-in-primary-care-in-the-netherlands
#13
Amber Awa van der Heijden, Simone P Rauh, Jacqueline M Dekker, Joline W Beulens, Petra Elders, Leen M 't Hart, Femke Rutters, Nienke van Leeuwen, Giel Nijpels
PURPOSE: People with type 2 diabetes (T2D) have a doubled morbidity and mortality risk compared with persons with normal glucose tolerance. Despite treatment, clinical targets for cardiovascular risk factors are not achieved. The Hoorn Diabetes Care System cohort (DCS) is a prospective cohort representing a comprehensive dataset on the natural course of T2D, with repeated clinical measures and outcomes. In this paper, we describe the design of the DCS cohort. PARTICIPANTS: The DCS consists of persons with T2D in primary care from the West-Friesland region of the Netherlands...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28582756/therapeutic-applications-of-synthetic-nucleic-acid-aptamers
#14
REVIEW
Suttinee Poolsup, Chu-Young Kim
It is possible to generate oligonucleotide aptamers for a wide variety of target molecules using a process known as Systematic Evolution of Ligands by Exponential Enrichment. Researchers have successfully generated aptamers which recognize specific metal ions, small chemical compounds, peptides, proteins, saccharides, and even whole cells. Aptamers show much promise as future therapeutics and as drug targeting agents. A particularly active area of aptamer research in the past two years was development of aptamer based cancer therapeutics and development of aptamer based cancer drug delivery systems...
June 2, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28580129/case-report-orbital-metastasis-as-the-presenting-feature-of-lung-cancer
#15
Sunil Munakomi, Samrita Chaudhary, Pramod Chaudhary, Jagdish Thingujam, Bijoy Mohan Kumar, Iype Cherian
Orbital metastasis from lung cancer as an initial presenting symptom is a rare entity, which may paradoxically delay the diagnosis and initiation of correct management, due to the confusion of it being primary orbital pathology. Herein we report a case of a 58 year old woman, who presented with painful orbital swelling along with diminution in her vision. The patient was initially thought to have a primary eye lesion; however chest X-ray was suggestive of a lung mass, which was confirmed by chest computed topography followed by ultrasound guided fine needle aspiration cytology...
2017: F1000Research
https://www.readbyqxmd.com/read/28578364/xeroderma-pigmentosum-at-a-tertiary-care-center-in-saudi-arabia
#16
Lenah Alwatban, Yousef Binamer
BACKGROUND: Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder caused by defective DNA repair that results in extreme sensitivity to ultraviolet (UV) rays. Depending on the type of XP, the disease may affect the skin, eyes and nervous system. OBJECTIVES: Describe the dermatologic manifestations in patients suffering from XP. DESIGN: Retrospective, descriptive review of medical records. SETTING: Dermatology clinic at tertiary care center in Riyadh...
May 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28576690/complement-component-c3ar-constitutes-a-novel-regulator-for-chick-eye-morphogenesis
#17
Erika Grajales-Esquivel, Agustin Luz-Madrigal, Jeffrey Bierly, Tracy Haynes, Edimara S Reis, Zeyu Han, Christian Gutierrez, Zachary McKinney, Apostolia Tzekou, John D Lambris, Panagiotis A Tsonis, Katia Del Rio-Tsonis
Complement components have been implicated in a wide variety of functions including neurogenesis, proliferation, cell migration, differentiation, cancer, and more recently early development and regeneration. Following our initial observations indicating that C3a/C3aR signaling induces chick retina regeneration, we analyzed its role in chick eye morphogenesis. During eye development, the optic vesicle (OV) invaginates to generate a bilayer optic cup (OC) that gives rise to the retinal pigmented epithelium (RPE) and neural retina...
May 30, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28576522/pd-l1-expression-and-cd8-infiltration-shows-heterogeneity-in-juvenile-recurrent-respiratory-papillomatosis
#18
Tingyu Liu, Max Greenberg, Carissa Wentland, Brandon Sepe, Sarah Bowe, Gillian Diercks, Tiffany Huynh, Mari Mino-Kenudson, Richard Schlegel, David Kodack, Cyril Benes, Jeffrey Engelman, Christopher Hartnick
INTRODUCTION: Tumor immunotherapy have broadened therapeutic options for tumor treatment. The role of immune function in juvenile recurrent respiratory papillomatosis (JRRP) has not been investigated. Applying immunoblockade inhibitors as a novel disease treatment is unclear. Our study, for the first time, evaluates immune infiltration and immuno-suppressive molecule expression in JRRP. Our study provides insights in possibly treating this disease with tumor immunotherapies. We aimed to determine expression of programmed death-ligand 1 (PD-L1), a cancer escape protein, and presence of CD8+ T cell infiltration in tumor microenvironment...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28562323/pdgfra-hsd17b4-and-hmgb2-are-potential-therapeutic-targets-in-polycystic-ovarian-syndrome-and-breast-cancer
#19
Huiyu Xu, Yong Han, Jiaying Lou, Hongxian Zhang, Yue Zhao, Balázs Győrffy, Rong Li
To explore the key genes associated with both PCOS and breast cancer, we overlapped the synchronously differently expressed genes in two obese insulin-resistant GEO datasets in muscle tissue and genes exert essential roles in breast cancer prognosis together base on the following reasons: (1) Androgens excess is believed to contribute to the onset of both PCOS and breast cancer. (2) PCOS is usually complicated with metabolic symptoms, such as obesity and insulin-resistance. (3) Muscle is the main place where energy metabolism and material metabolism take place...
May 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28562195/mhealth-app-for-risk-assessment-of-pigmented-and-nonpigmented-skin-lesions-a-study-on-sensitivity-and-specificity-in-detecting-malignancy
#20
Monique Thissen, Andreea Udrea, Michelle Hacking, Tanja von Braunmuehl, Thomas Ruzicka
BACKGROUND: With the advent of smartphone devices, an increasing number of mHealth applications that target melanoma identification have been developed, but none addresses the general context of melanoma and nonmelanoma skin cancer identification. INTRODUCTION: In this study a smartphone application using fractal and classical image analysis for the risk assessment of skin lesions is systematically evaluated to determine its sensitivity and specificity in the diagnosis of melanoma and nonmelanoma skin cancer along with actinic keratosis and Bowen's disease...
May 31, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
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