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JOURNAL ARTICLE
In-Seon Lee, Da-Eun Yoon, Seoyoung Lee, Jae-Hwan Kang, Younbyoung Chae, Hi-Joon Park, Junsuk Kim
PURPOSE: Only a few studies have focused on the brain mechanisms underlying the itch processing in AD patients, and a neural biomarker has never been studied in AD patients. We aimed to develop a deep learning model-based neural signature which can extract the relevant temporal dynamics, discriminate between AD and healthy control (HC), and between AD patients who responded well to acupuncture treatment and those who did not. PATIENTS AND METHODS: We recruited 41 AD patients (22 male, age mean ± SD: 24...
2024: Journal of Asthma and Allergy
#2
JOURNAL ARTICLE
Balázs Csoma, Nóra Sydó, Gergő Szűcs, Éva Seres, Tamás Erdélyi, Gábor Horváth, Emese Csulak, Béla Merkely, Veronika Müller
PURPOSE: Our aim was to evaluate the accuracy of a combined airway inflammatory biomarker assessment in diagnosing asthma in elite water sports athletes. METHODS: Members of the Hungarian Olympic and Junior Swim Team and elite athletes from other aquatic disciplines were assessed for asthma by objective lung function measurements, and blood eosinophil count (BEC), serum total IgE, FENO measurements, and skin prick testing were performed. A scoring system from BEC, FENO, serum IgE, and skin test positivity was constructed by dichotomising the variables and assigning a score of 1 if the variable is elevated...
April 23, 2024: Medicine and Science in Sports and Exercise
#3
JOURNAL ARTICLE
Shahriyar Shahbazi Khamas, Yoni Van Dijk, Mahmoud I Abdel-Aziz, Anne H Neerincx, Jelle Blankestijn, Susanne J H Vijverberg, Simone Hashimoto, Andrew Bush, Aletta D Kraneveld, Anna M Hedman, Antoaneta A Toncheva, Catarina Almqvist, Christine Wolff, Clare S Murray, Gunilla Hedlin, Graham Roberts, Ian M Adcock, Javier Korta-Murua, Klaus Bønnelykke, Louise J Fleming, Maria Pino-Yanes, Mario Gorenjak, Michael Kabesch, Olaia Sardón-Prado, Paolo Montuschi, Florian Singer, Paula Corcuera-Elosegui, Stephen J Fowler, Susanne Brandstetter, Susanne Harner, Sven-Erik Dahlén, Uroš Potočnik, Urs Frey, Wim van Aalderen, Paul Brinkman, Anke H Maitland-van der Zee
RATIONALE: Early identification of children with poorly controlled asthma is imperative for optimizing treatment strategies. The analysis of exhaled volatile organic compounds (VOCs) is an emerging approach to identify prognostic and diagnostic biomarkers in pediatric asthma. OBJECTIVES: To assess the accuracy of gas chromatography-mass spectrometry based exhaled metabolite analysis to differentiate between controlled and uncontrolled pediatric asthma. METHODS: This study encompassed a discovery (SysPharmPediA) and validation phase (U-BIOPRED, PANDA)...
April 22, 2024: American Journal of Respiratory and Critical Care Medicine
#4
JOURNAL ARTICLE
Fuying Zhang, Xiang Weng, Jiabao Zhu, Qin Tang, Mingsheng Lei, Weimin Zhou
Severe asthma is characterized by a poor level of control that severely affects the patient's life and prognosis. However, the underlying pathogenic mechanisms remain unknown. Here, we identified differentially expressed genes from the microarray datasets(GSE130499 and GSE63142) of severe asthma, and then constructed models to screen the most relevant biomarkers to severe asthma by machine learning algorithms(LASSO and SVM-RFE), with further validation of the results by GSE43696. Three genes ( BCL3 , DDIT4 and S100A14 ) are considered as biomarkers of severe asthma and had good diagnostic effect...
April 22, 2024: Journal of Asthma
#5
JOURNAL ARTICLE
Xiaoyi Ji, Chunhua Nie, Yuan Yao, Yu Ma, Huafei Huang, Chuangli Hao
BACKGROUND: Allergic asthma is the most prevalent asthma phenotype and is associated with the disorders of immune cells and glycolysis. Macrophages are the most common type of immune cells in the lungs. Calprotectin (S100A8 and S100A9) are two pro-inflammatory molecules that target the Toll-like receptor 4 (TLR4) and are substantially increased in the serum of patients with severe asthma. This study aimed to determine the effects of S100A8/A9 on macrophage polarization and glycolysis associated with allergic asthma...
2024: PeerJ
#6
EDITORIAL
Kjell Alving
No abstract text is available yet for this article.
April 17, 2024: Journal of Allergy and Clinical Immunology in Practice
#7
JOURNAL ARTICLE
Qianqian Liu, Xiaoli Tang, Haipeng Xu, Jie Wen, Yangyang Chen, Shoubin Xue
BACKGROUND: Asthma ranks among the most prevalent non-communicable diseases worldwide. Previous studies have elucidated the significant role of the immune system in its pathophysiology. Nevertheless, the immune-related mechanisms underlying asthma are complex and still inadequately understood. Thus, our objective was to investigate novel key biomarkers and immune infiltration characteristics associated with asthma by employing integrated bioinformatics tools. METHODS: In this study, we conducted a weighted gene co-expression network analysis (WGCNA) to identify key modules and genes potentially implicated in asthma...
April 19, 2024: Medicine (Baltimore)
#8
JOURNAL ARTICLE
Chunyu Luo, Ying Zhu, Shiyao Zhang, Jiayao Zhou, Song Mao, Ru Tang, Yuelong Gu, Shaolin Tan, Hai Lin, Zhipeng Li, Weitian Zhang
BACKGROUND: SERPINB2, a biomarker of Type-2 (T2) inflammatory processes, has been described in the context of asthma. Chronic rhinosinusitis with nasal polyps (CRSwNP) is also correlated with T2 inflammation and elevated 15LO1 induced by IL-4/13 in nasal epithelial cells. The aim of this study was to evaluate the expression and location of SERPINB2 in nasal epithelial cells (NECs) and determine whether SERPINB2 regulates 15LO1 and downstream T2 markers in NECs via STAT6 signalling. METHODS: SERPINB2 gene expression in bulk and single-cell RNAseq database was analysed by bioinformatics analysis...
April 19, 2024: Clinical and Experimental Allergy
#9
Praveen Hariharan, Lina Nemchenok, Mohanad Hadi, Vaugh Williams, Angela Caliendo
Eosinophilia is known to be associated with a multitude of co-morbidities. However, unexplained eosinophilia poses a diagnostic challenge, and the methods used to investigate unexplained eosinophilia vary from region to region. In this case report, we describe a unique case of a young female presenting with marked eosinophilia to a tertiary hospital in the northeastern United States. Our patient presented with a few weeks of lower extremity rash, gait instability, and new onset marked eosinophilia. We further report the investigations undertaken during the hospitalization to highlight the broad differential diagnoses...
March 2024: Curēus
#10
JOURNAL ARTICLE
Yangli Liu, Fengjia Chen, Zhimin Zeng, Chengcheng Lei, Dubo Chen, Xiaoyu Zhang
BACKGROUND AND OBJECTIVE: Endothelial dysfunction has been widely recognized in chronic airway diseases, including chronic obstructive pulmonary disease (COPD) and asthma; however, it remains unclear in asthma-COPD overlap (ACO). Neopterin (NP), a metabolite of guanosine triphosphate, is a novel biomarker for identifying the increased risk of adverse cardiovascular events. This study aims to investigate the association of NP with endothelial dysfunction and impaired lung function in COPD, asthma, and ACO patients...
April 18, 2024: Respiratory Research
#11
JOURNAL ARTICLE
Ratko Djukanović, Paul Brinkman, Johan Kolmert, Cristina Gomez, James Schofield, Joost Brandsma, Andy Shapanis, Paul J S Skipp, Anthony Postle, Craig Wheelock, Sven-Erik Dahlen, Peter J Sterk, Thomas Brown, David J Jackson, Adel Mansur, Ian Pavord, Mitesh Patel, Christopher Brightling, Salman Siddiqui, Peter Bradding, Ian Sabroe, Dinesh Saralaya, Livingstone Chishimba, Joanna Porter, Douglas Robinson, Stephen Fowler, Peter H Howarth, Louisa Little, Thomas Oliver, Kayleigh Hill, Louise Stanton, Alexander Allen, Deborah Ellis, Gareth Griffiths, Tim Harrison, Ayobami Akenroye, Jessica Lasky-Su, Liam Heaney, Rekha Chaudhuri, Ramesh Kurukulaaratchy
BACKGROUND: The anti-IgE monoclonal, omalizumab, is widely used for severe asthma. This study aimed to identify biomarkers that predict clinical improvement during one year of omalizumab treatment. METHODS: 1-year, open-label, S tudy o f M echanisms of action of O malizumab in S evere A sthma ( SoMOSA ) involving 216 severe (GINA step 4/5) uncontrolled atopic asthmatics (≥2 severe exacerbations in previous year) on high-dose inhaled corticosteroids, long-acting β-agonists, ± mOCS...
April 18, 2024: American Journal of Respiratory and Critical Care Medicine
#12
REVIEW
Karolina Wieczorek, Sachin Ananth, Diana Valazquez-Pimentel
OBJECTIVE: Current monitoring methods of asthma, such as peak expiratory flow testing, have important limitations. The emergence of automated acoustic sound analysis, capturing cough, wheeze, and inhaler use, offers a promising avenue for improving asthma diagnosis and monitoring. This systematic review evaluated the validity of acoustic biomarkers in supporting the diagnosis of asthma and its monitoring. DATA SOURCES: A search was performed using two databases (PubMed and Embase) for all relevant studies published before November 2023...
April 18, 2024: Journal of Asthma
#13
REVIEW
Haoran Shen, Rui Zheng, Mulong Du, David C Christiani
BACKGROUND: Individual exposure to environmental pollutants, as one of the most influential drivers of respiratory disorders, has received considerable attention due to its preventability and controllability. Considering that the extracellular vesicle (EV) was an emerging intercellular communication medium, recent studies have highlighted the crucial role of environmental pollutants derived EVs (EPE-EVs) in respiratory disorders. METHODS: PubMed and Web of Science were searched from January 2018 to December 2023 for publications with key words of environmental pollutants, respiratory disorders and EVs...
April 17, 2024: Thorax
#14
JOURNAL ARTICLE
Kedir N Turi, Yajing Li, Yaomin Xu, Tebeb Gebretsadik, Christian Rosas-Salazar, Derek A Wiggins, Chris McKennan, Dawn Newcomb, James E Gern, Tina V Hartert
BACKGROUND: Adrenal steroids play important roles in early life development. However, our understanding of the effects of perinatal adrenal steroids on the development of childhood asthma is incomplete. OBJECTIVE: This study aimed to evaluate the associations between early life adrenal steroid levels and childhood asthma. METHODS: Participants included INSPIRE birth cohort children with untargeted urinary metabolomics data measured during early infancy (n=264) and nasal immune mediator data measured concurrently at age 2-6 months (n=76)...
April 15, 2024: Annals of Allergy, Asthma & Immunology
#15
JOURNAL ARTICLE
Flory L Nkoy, Bryan L Stone, Yue Zhang, Gang Luo
Inhaled corticosteroid (ICS) is a mainstay treatment for controlling asthma and preventing exacerbations in patients with persistent asthma. Many types of ICS drugs are used, either alone or in combination with other controller medications. Despite the widespread use of ICSs, asthma control remains suboptimal in many people with asthma. Suboptimal control leads to recurrent exacerbations, causes frequent ER visits and inpatient stays, and is due to multiple factors. One such factor is the inappropriate ICS choice for the patient...
April 17, 2024: JMIR Medical Informatics
#16
JOURNAL ARTICLE
Claudio Candia, Pasquale Ambrosino, Silvestro E D'Anna, Andrea Motta, Mauro Maniscalco
Two recent articles by the same research group documented that patients with severe eosinophilic asthma exhibit an increased proportion of a subtype of eosinophils, namely CD62Llow inflammatory eosinophils (iEos) and identified an intriguing correlation between such iEos and asthma control scores. Moreover, CD62Llow iEos were reduced after treatment with the anti-IL-5 monoclonal antibody mepolizumab. In the future, we believe that eosinophil subtypes could represent a useful biomarker in severe eosinophilic asthma, helping clinicians characterize patient endotypes and monitoring the response to biological drugs...
April 16, 2024: Biomarkers in Medicine
#17
JOURNAL ARTICLE
Melissa A Kovach, Ulrika Käck, Karlhans F Che, Bettina Brundin, Jon R Konradsen, Anders Lindén
BACKGROUND: Interleukin (IL)-26 is produced by T helper type 17 (Type 17) cells and exerts immunomodulatory plus antimicrobial effects. Previous studies show that local IL-26 concentrations in the airways are higher in patients with uncontrolled than in those with controlled asthma, and that this intriguing cytokine bears biomarker potential. Here, we determined how systemic IL-26 relates to allergen sensitization, asthma severity, and to IL-17 A in children. METHODS: Serum samples were obtained from children with (n = 60) and without (n = 17) sensitization to dog allergen, and IL-26 and IL-17 A protein concentrations were measured using ELISA...
April 15, 2024: Respiratory Research
#18
JOURNAL ARTICLE
Maria Luiza Lima-Silva, Karen Cecília Lima Torres, Juliana Vaz de Melo Mambrini, Nathalia Coimbra de Brot, Sara de Oliveira Santos, Olindo Assis Martins-Filho, Andréa Teixeira-Carvalho, Maria Fernanda Lima-Costa, Sérgio Viana Peixoto
Immunosenescence is a phenomenon caused by changes in the immune system, and part of these changes involves an increase in circulating immunological biomarkers, a process known as "Inflammaging." Inflammaging can be associated with many diseases related to older people. As the older population continues to grow, understanding changes in the immune system becomes essential. While prior studies assessing these alterations have been conducted in countries with Caucasian populations, this investigation marks a pioneering effort...
April 13, 2024: Experimental Gerontology
#19
JOURNAL ARTICLE
8-Iso-prostaglandin F2α as a biomarker of T2-low airway inflammation and remodeling in adult asthma.
Seong-Dae Woo, Hee Sun Park, Eun-Mi Yang, Ga-Young Ban, Hae-Sim Park
BACKGROUND: Although 8-iso-prostaglandin F2a has been proposed as a potential biomarker for oxidative stress in airway diseases, its specific role in asthma remains poorly understood. OBJECTIVE: To evaluate the diagnostic potential of 8-iso-prostaglandin F2a in assessing airway inflammation, airway remodeling, airway hyperresponsiveness, and oxidative stress in asthma. METHODS: Blood and urine concentrations of 8-iso-prostaglandin F2a were quantified using liquid chromatography-tandem mass spectrometry in 128 adults with asthma who had maintained anti-asthmatic medications...
April 12, 2024: Annals of Allergy, Asthma & Immunology
#20
JOURNAL ARTICLE
Nok Him Fung, Quynh Anh Nguyen, Catherine Owczarek, Nick Wilson, Nadeem Elahee Doomun, David De Souza, Kylie Quinn, Stavros Selemidis, Jonathan McQualter, Ross Vlahos, Hao Wang, Steven Bozinovski
BACKGROUND: Longitudinal studies have identified childhood asthma as a risk factor for obstructive pulmonary disease (COPD) and asthma-COPD overlap (ACO) where persistent airflow limitation can develop more aggressively. However, a causal link between childhood asthma and COPD/ACO remains to be established. Our study aimed to model the natural history of childhood asthma and COPD and to investigate the cellular/molecular mechanisms that drive disease progression. METHODS: Allergic airways disease was established in three-week-old young C57BL/6 mice using house dust mite (HDM) extract...
April 13, 2024: Respiratory Research
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