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https://www.readbyqxmd.com/read/29228205/associations-between-polymorphisms-in-genes-related-to-estrogen-metabolism-and-function-and-prostate-cancer-risk-results-from-the-prostate-cancer-prevention-trial
#1
Li Tang, Mary E Platek, Song Yao, Cathee Till, Phyllis J Goodman, Catherine M Tangen, Yue Wu, Elizabeth A Platz, Marian L Neuhouser, Frank Z Stanczyk, Juergen K V Reichardt, Regina M Santella, Ann Hsing, William D Figg, Scott M Lippman, Ian M Thompson, Christine B Ambrosone
Substantial preclinical data suggest estrogen's carcinogenic role in prostate cancer development; however, epidemiological evidence based on circulating estrogen levels is largely null. Compared with circulating estrogen, the intraprostatic estrogen milieu may play a more important role in prostate carcinogenesis. Using a nested case-control design in the Prostate Cancer Prevention Trial (PCPT), we examined associations of genetic variants of genes that are involved in estrogen synthesis, metabolism and function with prostate cancer risk...
December 8, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29226993/genetic-polymorphisms-of-microrna-machinery-genes-predict-overall-survival-of-esophageal-squamous-carcinoma
#2
Cuiju Wang, Hailing Dong, Haiyan Fan, Jianhua Wu, Guiying Wang
BACKGROUND: MicroRNA (miRNA)-related single nucleotide polymorphisms (miR-SNPs) in miRNA processing machinery genes are implicated in carcinogenesis, as they change the expression profiles of miRNA. Six miR-SNPs in miRNA processing machinery genes, including Dicer (rs3742330), RAN (rs14035), XPO5 (rs11077), TNRC6B (rs9623117), GEMIN3 (rs197412), and GEMIN4 (rs2740348), were evaluated for their association with esophageal squamous cell carcinoma (ESCC). METHODS: The miR-SNP of the miRNA processing genes were genotyped using the polymerase chain reaction-ligase detection reaction (PCR-LDR) assay, while the XPO5 expression levels in ESCC tissues were measured by immunochemistry methods...
December 11, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29221206/single-nucleotide-polymorphisms-rs701848-and-rs2735343-in-pten-increases-cancer-risks-in-an-asian-population
#3
Dan-Dan Song, Qian Zhang, Jing-Hua Li, Rui-Min Hao, Ying Ma, Ping-Yu Wang, Shu-Yang Xie
We performed this meta-analysis to analyze the cancer risk to individuals carrying the rs701848 and rs2735343 single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) gene. We searched the PubMed, EMBASE, Cochrane library and the national knowledge infrastructure of China (CNKI) databases and identified 18 eligible case-control studies with 5458 cases and 6003 controls for rs701848 as well as 5490 cases and 6209 controls for rs2735343. Our analyses demonstrated that cancer risk was associated with rs701848 in the recessive model (CC vs...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220587/fto-gene-affects-obesity-and-breast-cancer-through-similar-mechanisms-a-new-insight-into-the-molecular-therapeutic-targets
#4
M E Akbari, M Gholamalizadeh, S Doaei, F Mirsafa
OBJECTIVES: This review focused on the possible mediatory role of the FTO in the association between obesity and breast cancer. METHOD: All articles published in English from June 1990 to January 2017 were studied. The search terms used were FTO gene, FTO polymorphism, breast cancer, and obesity. Inclusion criteria consisted of assessment of the relationship between FTO polymorphisms and/or FTO expression level with obesity and/or breast cancer as a primary outcome...
December 8, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29218624/motivation-for-launching-a-cancer-metastasis-inhibition-cmi-program
#5
REVIEW
Jill M Pulley, Rebecca N Jerome, Martin L Ogletree, Gordon R Bernard, Robert R Lavieri, Nicole M Zaleski, Charles C Hong, Jana K Shirey-Rice, Carlos L Arteaga, Ingrid A Mayer, Kenneth J Holroyd, Rebecca S Cook
Metastatic cancers impose significant burdens on patients, affecting quality of life, morbidity, and mortality. Even during remission, microscopic metastases can lurk, but few therapies directly target tumor cell metastasis. Agents that interfere with this process would represent a new paradigm in cancer management, changing the 'waiting game' into a time of active prevention. These therapies could take multiple forms based on the pathways involved in the metastatic process. For example, a phenome-wide association study showed that a single nucleotide polymorphism in the gene TBXA2R is associated with increased metastasis in multiple primary cancers (P = 0...
December 7, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/29215312/gstm1-and-gstt1-gene-polymorphisms-gene-gene-interaction-and-esophageal-carcinoma-risk-evidence-from-an-updated-meta-analysis
#6
Liping Ma, Biyang Lan, Lingxiao Guo, Shaoyun Nong, Cuibo Huang, Qiulong Wu, Zhihu Huang
BACKGROUND: Published data regarding the association between GSTM1 and/or GSTT1 gene polymorphisms and esophageal cancer (EC) susceptibility remain inconclusive. To clarify these associations, a meta-analysis was conducted. METHODS: We conducted a comprehensive search in PubMed, Embase, and the China National Knowledge Infrastructure (CNKI) for all such manuscripts published as of May 1, 2017. The pooled odds ratio (ORs) with confidence intervals (95% CI) were estimated for each study to assess the strength of the association...
December 7, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29212267/development-of-diagnostic-model-of-lung-cancer-based-on-multiple-tumor-markers-and-data-mining
#7
Zhaoxian Wang, Feifei Feng, Xiaoshan Zhou, Liju Duan, Jing Wang, Yongjun Wu, Na Wang
Objective: To develop early intelligent discriminative model of lung cancer and evaluate the efficiency of diagnosis value. Methods: Based on the genetic polymorphism profile of CYP1A1-rs1048943, GSTM1, mEH-rs1051740, XRCC1-rs1799782 and XRCC1-rs25489 and the methylations of p16 and RASSF1A gene, and the length of telomere in the peripheral blood from 200 lung cancer patients and 200 health persons, the discriminative model was established through decision tree and ANN technique...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212235/ager-rs2070600-polymorphism-elevates-neutrophil-lymphocyte-ratio-and-mortality-in-metastatic-lung-adenocarcinoma
#8
Kakuhiro Yamaguchi, Hiroshi Iwamoto, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Background: The receptor for advanced glycation end-product (RAGE) is a multi-ligand receptor involved in inflammation. In the gene encoding RAGE (AGER), there are three well-known polymorphisms; rs2070600, rs1800624, and rs1800625, which potentially increase the risk of lung cancer. Remarkably, AGER rs2070600 polymorphism, which increases ligand-binding affinity, is a potential prognostic factor in non-small cell lung cancer, but the underlying mechanism is unclear. The neutrophil-lymphocyte ratio (NLR) reflects tumor-associated systemic inflammatory conditions; high ratios are associated with poor prognosis in multiple cancers...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29210328/dna-variants-in-dhfr-gene-and-response-to-treatment-in-children-with-childhood-b-all-revisited-in-aieop-bfm-protocol
#9
Francesco Ceppi, Vincent Gagné, Laurance Douyon, Camille J Quintin, Antonella Colombini, Rosanna Parasole, Barbara Buldini, Giuseppe Basso, Valentino Conter, Giovanni Cazzaniga, Maja Krajinovic
AIM: We have previously reported an association of dihydrofolate reductase promoter polymorphisms with reduced event-free survival in childhood acute lymphoblastic leukemia (ALL) patients treated with Dana Farber Cancer Institute protocol. Here, we assessed whether these associations are applicable to other protocol, based on different methotrexate doses. METHODS: Genotypes for six tag polymorphisms and resulting haplotypes were analyzed for an association with ALL outcome...
December 6, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/29210057/a-functional-polymorphism-in-tff1-promoter-is-associated-with-the-risk-and-prognosis-of-gastric-cancer
#10
Weizhi Wang, Zheng Li, Jiwei Wang, Mulong Du, Bowen Li, Lei Zhang, Qing Li, Jianghao Xu, Linjun Wang, Fengyuan Li, Diancai Zhang, Hao Xu, Li Yang, Weida Gong, Fulin Qiang, Zhengdong Zhang, Zekuan Xu
Trefoil Factor 1 (TFF1, also named pS2), which serves as the gastrointestinal mucosal protector, is known as gastric-specific tumor suppressor gene. However, the genetic variants of TFF1 are still not well studied. In this study, we aim to explore the effects of tagging single nucleotide polymorphisms (tagSNPs) of TFF1 on risk and prognosis of gastric cancer. Seven tagSNPs of TFF1 gene were first analyzed in the test set, which was consisted of 753 cases and 950 cancer-free controls. Then, the validation set (940 cases and 1,042 controls) was used for further evaluation...
December 6, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29209987/genetic-investigation-of-polymorphic-ogg1-and-mutyh-genes-towards-increased-susceptibility-in-lung-adenocarcinoma-and-its-impact-on-overall-survival-of-lung-cancer-patients-treated-with-platinum-based-chemotherapy
#11
Amrita Singh, Navneet Singh, Digambar Behera, Siddharth Sharma
Genes OGG1 and MUTYH are the two primary genes in Base excision repair pathway. OGG1 hydrolyzes the sugar phosphate backbone and remove the damaged base creating abasic site. MUTYH complements OGG1 as it particularly remove adenine mispaired with 8-oxo-G. Both OGG1 and MUTYH act as a check for the mis-incorporation of bases may be due to damages incurred on DNA. DNA isolation for 326 lung cancer cases and 330 controls was followed by genotyping making use of PCR-RFLP. Logistic regression was done to analyze the risk towards lung cancer...
December 5, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29209986/data-on-single-nucleotide-polymorphism-of-dna-repair-genes-and-breast-cancer-risk-from-poland
#12
Beata Smolarz, Magdalena Bryś, Ewa Forma, Marek Zadrożny, Jan Bieńkiewicz, Hanna Romanowicz
Single nucleotide polymorphisms (SNPs) may modify the risk of cancer. They may be then regarded as potential markers of carcinogenesis. The aim of this study was to analyze the frequency of genotypes and alleles of SNPs in DNA repair genes and to investigate the influence this genetic variation exerts on breast cancer in Polish females. The test group comprised 600 females with breast cancer and 600 healthy controls. Genomic DNA was isolated and the SNPs in DNA repair genes were determined by High-Resolution Melter (HRM) technique...
December 5, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29208668/a-polymorphism-within-the-vitamin-d-transporter-gene-predicts-outcome-in-metastatic-colorectal-cancer-patients-treated-with-folfiri-bevacizumab-or-folfiri-cetuximab
#13
Martin D Berger, Sebastian Stintzing, Volker Heinemann, Shu Cao, Dongyun Yang, Yu Sunakawa, Satoshi Matsusaka, Yan Ning, Satoshi Okazaki, Yuji Miyamoto, Mitsukuni Suenaga, Marta Schirripa, Diana L Hanna, Shivani Soni, Alberto Puccini, Wu Zhang, Chiara Cremolini, Alfredo Falcone, Fotios Loupakis, Heinz-Josef Lenz
PURPOSE: Vitamin D exerts its inhibitory influence on colon cancer growth by inhibiting Wnt signaling and angiogenesis. We hypothesized that SNPs in genes involved in vitamin D transport, metabolism and signaling are associated with outcome in metastatic colorectal cancer (mCRC) patients treated with first-line FOLFIRI and bevacizumab (bev). EXPERIMENTAL DESIGN: 522 mCRC patients enrolled in the FIRE-3 (discovery cohort) and TRIBE (validation set) trials treated with FOLFIRI/bev were included in this study...
December 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29208650/transcriptional-profiling-of-saccharomyces-cerevisiae-reveals-the-impact-of-variation-of-a-single-transcription-factor-on-differential-gene-expression-in-4nqo-fermentable-and-non-fermentable-carbon-sources
#14
Xiaqing Rong-Mullins, Michael C Ayers, Mahmoud Summers, Jennifer E G Gallagher
Cellular metabolism can change the potency of a chemical's tumorigenicity. 4-nitroquinoline-1-oxide (4NQO) is a tumorigenic drug widely used on animal models for cancer research. Polymorphisms of the transcription factor, Yrr1, confer different levels of resistance to 4NQO in Saccharomyces cerevisiae To study how different Yrr1 alleles regulate gene expression leading to resistance, transcriptomes of three isogenic Scerevisiae strains carrying different Yrr1 alleles were profiled via RNA sequencing (RNA-Seq) and chromatin immunoprecipitation coupled with sequencing (ChIP-Seq) in presence and absence of 4NQO...
December 5, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29207732/pre-microrna-gene-polymorphisms-and-risk-of-cervical-squamous-cell-carcinoma
#15
Shruti Srivastava, Shalini Singh, Naseem Fatima, Balraj Mittal, Anand Narain Srivastava
Introduction: MicroRNAs (miRNAs) are short (~22 nucleotides) regulatory RNAs that can modulate gene expression and are aberrantly expressed in many diseases, including cancer. It has been suggested that, the presence of single nucleotide polymorphisms in precursor miRNAs (pre-miRNAs) can alter miRNA processing, expression and binding to target mRNA and represents another type of genetic variability, that can contribute to the susceptibility of human cancers. Aim: The present study investigated the genetic variants in pre-miRNAs (hsa-miRNA-196a2 rs11614913 C/T, hsa-miRNA-499 rs3746444 T/C and hsa-miRNA-146a rs2910164 G/C) for their role in cervical cancer susceptibility...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207674/genetic-polymorphisms-in-caveolin-1-associate-with-breast-cancer-risk-in-chinese-han-population
#16
Meng Wang, Tian Tian, Xiaobin Ma, Wenge Zhu, Yan Guo, Zhao Duan, Jiangbo Fan, Shuai Lin, Kang Liu, Yi Zheng, Qianwen Sheng, Zhi-Jun Dai, Huixia Peng
Caveolin-1(CAV-1) was demonstrated to be a tumor suppressor gene and be implicated in the development of breast cancer (BC). Numerous potentially functional polymorphisms in CAV-1 have been identified, but their effects on BC were not clear. This case-control study aims to evaluate the relationship between CAV-1 polymorphisms and BC risk. 560 BC patients and 583 healthy controls were enrolled in the present study, all from Chinese Han population. We detected 3 single nucleotide polymorphisms (rs3807987, rs1997623, and rs7804372) in CAV-1 using the Sequenom MassARRAY method...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207078/characterizing-key-nucleotide-polymorphisms-of-hepatitis-c-virus-disease-associations-via-mass-spectrometric-genotyping
#17
Yuta Horiuchi, Jason Lin, Yui Shinojima, Kyoko Fujiwara, Mitsuhiko Moriyama, Hiroki Nagase
As more than 80% of hepatocellular carcinoma patients in Japan also suffer from hepatitis C virus infections some time in their medical history, identifying genetic aberrations associated to hepatitis C virulence in these individuals remains a high priority in the diagnosis and treatment of hepatocellular carcinoma. From the BioBank Japan Project, we acquired 480 subjects of hepatocellular carcinoma, chronic hepatitis and liver cirrhosis, and genotyped 131 clinically relevant host single nucleotide polymorphisms to survey the potential association between certain risk alleles and genes to a patient's predisposition to hepatitis C and liver cancer...
November 22, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29206716/primary-epithelioid-angiosarcoma-of-finger-masquerading-as-epithelioid-hemangioma-report-of-a-case-and-analysis-of-mutational-pattern-in-epithelioid-hemangiomas-and-angiosarcomas-by-next-generation-sequencing
#18
Manish M Subramaniam, Nur L Salleh, Bingcheng Wu, Michelle A Rozario, HueyJin Lim, Mark E Puhaindran, Richie Soong, Victor K Lee
AIMS: We report an unusual case of epithelioid angiosarcoma (AS) mimicking an epithelioid hemangioma (EH) and analyze mutational patterns in EHs and ASs. METHODS AND RESULTS: A 58-year-old woman presented with a finger lump and metastatic lung nodules. Initial needle biopsies showed an EH, with only focal atypical histologic features. The patient underwent finger amputation and resection of lung nodules. The amputation specimen and lung nodules revealed features of AS...
January 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29206297/dickkopf-homolog-3-dkk3-a-candidate-for-detection-and-treatment-of-cancers
#19
REVIEW
Leila Hamzehzadeh, Michele Caraglia, Stephen L Atkin, Amirhossein Sahebkar
Wnt signaling is an evolutionary highly conserved pathway that is modulated by several inhibitors and activators, and plays a key role in numerous physiological processes. One of the extracellular Wnt inhibitors is the DKK (Dickkopf Homolog) family which has four members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1 (soggy). DKK3 is a divergent member of the DKK protein family. Evidence suggests that DKK3 may serve as a potential therapeutic target in several types of human cancers. We review here the biological role of DKK3 as a tumor suppressor gene (TSG) or oncogene, and its correlation with various miRNAs...
December 5, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29199606/association-of-il-6-597-g-a-polymorphism-with-cancer-risk-evidence-from-a-meta-analysis
#20
Dingliang Qian, Shaorong Yan, Xiaowei Pan
Although it has been suggested that the interleukin-6(IL-6) gene -597G/A polymorphism may be a risk factor for cancer, the conclusions from previous studies are inconsistent. To clarify the precise interrelation, we performed a comprehensive meta-analysis of 6 case-control studies involving 1,605 subjects (706 cases and 899 controls). The overall results showed no significant association between the IL6 -597G/A polymorphism and cancer risk in the overall population (CC vs GG: OR = 2.38, 95% CI = 0.62-9.14; CG vs GG: OR = 1...
2017: Critical Reviews in Eukaryotic Gene Expression
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