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https://www.readbyqxmd.com/read/28323850/ligand-guided-homology-modelling-of-the-gabab2-subunit-of-the-gabab-receptor
#1
Thibaud Freyd, Dawid Warszycki, Stefan Mordalski, Andrzej J Bojarski, Ingebrigt Sylte, Mari Gabrielsen
γ-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, and disturbances in the GABAergic system have been implicated in numerous neurological and neuropsychiatric diseases. The GABAB receptor is a heterodimeric class C G protein-coupled receptor (GPCR) consisting of GABAB1a/b and GABAB2 subunits. Two GABAB receptor ligand binding sites have been described, namely the orthosteric GABA binding site located in the extracellular GABAB1 Venus fly trap domain and the allosteric binding site found in the GABAB2 transmembrane domain...
2017: PloS One
https://www.readbyqxmd.com/read/28318133/transcatheter-aortic-valve-implantation-with-the-self-expandable-venus-a-valve-and-corevalve-devices-preliminary-experiences-in-china
#2
Yan-Biao Liao, Zhen-Gang Zhao, Xin Wei, Yuan-Ning Xu, Zhi-Liang Zuo, Yi-Jian Li, Ming-Xia Zheng, Yuan Feng, Mao Chen
BACKGROUND: Transcatheter aortic valve implantation (TAVI) has been demonstrated to be an effective alternative to surgical aortic valve replacement (SAVR) in patients with aortic stenosis who are deemed high risk or inoperable. Currently, TAVI procedures in China mostly make use of the domestic Venus A-Valve and the CoreValve; however, there is no data on their comparative performance. METHODS: Consecutive patients undergoing TAVI with the aforementioned devices were included...
March 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28288001/programmable-snapping-composites-with-bio-inspired-architecture
#3
Jascha U Schmied, Hortense Le Ferrand, Paolo Ermanni, André R Studart, Andres F Arrieta
The development of programmable self-shaping materials enables the onset of new and innovative functionalities in many application fields. Commonly, shape adaptation is achieved by exploiting diffusion-driven swelling or nano-scale phase transition, limiting the change of shape to slow motion predominantly determined by the environmental conditions and/or the materials specificity. To address these shortcomings, we report shape adaptable programmable shells that undergo morphing via a snap-through mechanism inspired by the Dionaea muscipula leaf, known as the Venus fly trap...
March 13, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28282240/pseudoxanthoma-elasticum-like-papillary-dermal-elastolysis
#4
Venus Valbuena, Dalal Assaad, Jensen Yeung
BACKGROUND: Pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-PDE), a rare acquired elastolytic disorder, occurs in postmenopausal, elderly women and is characterized by soft, white-yellow papules that localize on the neck and supraclavicular regions and often coalesce into cobblestone plaques. It has no systemic involvement and is histologically distinct from the clinically similar inherited pseudoxanthoma elasticum. CASE SUMMARY: A 64-year-old Caucasian woman presented with a 2-year history of multiple, asymptomatic soft yellow 1- to 2-mm papules on her neck, which were increasing in number...
March 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28271476/%C3%AE-2-macroglobulins-structure-and-function
#5
Irene Garcia-Ferrer, Aniebrys Marrero, F Xavier Gomis-Rüth, Theodoros Goulas
α2-macroglobulins are broad-spectrum endopeptidase inhibitors, which have to date been characterised from metazoans (vertebrates and invertebrates) and Gram-negative bacteria. Their structural and biochemical properties reveal two related modes of action: the "Venus flytrap" and the "snap-trap" mechanisms. In both cases, peptidases trigger a massive conformational rearrangement of α2-macroglobulin after cutting in a highly flexible bait region, which results in their entrapment. In some homologs, a second action takes place that involves a highly reactive β-cysteinyl-γ-glutamyl thioester bond, which covalently binds cleaving peptidases and thus contributes to the further stabilization of the enzyme:inhibitor complex...
2017: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/28265703/biotechnological-production-of-organic-acids-from-renewable-resources
#6
Daniel Pleissner, Donna Dietz, Jozef Bernhard Johann Henri van Duuren, Christoph Wittmann, Xiaofeng Yang, Carol Sze Ki Lin, Joachim Venus
Biotechnological processes are promising alternatives to petrochemical routes for overcoming the challenges of resource depletion in the future in a sustainable way. The strategies of white biotechnology allow the utilization of inexpensive and renewable resources for the production of a broad range of bio-based compounds. Renewable resources, such as agricultural residues or residues from food production, are produced in large amounts have been shown to be promising carbon and/or nitrogen sources. This chapter focuses on the biotechnological production of lactic acid, acrylic acid, succinic acid, muconic acid, and lactobionic acid from renewable residues, these products being used as monomers for bio-based material and/or as food supplements...
March 7, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/28265006/characterization-of-the-anti-pd-1-antibody-regn2810-and-its-antitumor-activity-in-human-pd-1-knock-in-mice
#7
Elena Burova, Aynur Hermann, Janelle Waite, Terra Potocky, Venus Lai, Seongwon Hong, Matt Liu, Omaira Allbritton, Amy Woodruff, Qi Wu, Amanda D'Orvilliers, Elena Garnova, Ashique Rafique, William Poueymirou, Joel Martin, Tammy Huang, Dimitris Skokos, Joel Kantrowitz, Jon Popke, Markus Mohrs, Douglas MacDonald, Ella Ioffe, William Olson, Israel Lowy, Andrew Murphy, Gavin Thurston
The Programmed Death-1 (PD-1) receptor delivers inhibitory checkpoint signals to activated T cells upon binding to its ligands PD-L1 and PD-L2 expressed on antigen presenting cells and cancer cells, resulting in suppression of T cell effector function and tumor immune evasion. Clinical antibodies blocking the interaction between PD-1 and PD-L1 restore the cytotoxic function of tumor antigen-specific T cells, yielding durable objective responses in multiple cancers. This report describes the preclinical characterization of REGN2810, a fully human hinge-stabilized IgG4 (S228P) high-affinity anti-PD-1 antibody that potently blocks PD-1 interactions with PD-L1 and PD-L2...
March 6, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28263544/smart-actuators-and-adhesives-for-reconfigurable-matter
#8
Hyunhyub Ko, Ali Javey
Biological systems found in nature provide excellent stimuli-responsive functions. The camouflage adaptation of cephalopods (octopus, cuttlefish), rapid stiffness change of sea cucumbers, opening of pine cones in response to humidity, and rapid closure of Venus flytraps upon insect touch are some examples of nature's smart systems. Although current technologies are still premature to mimic these sophisticated structures and functions in smart biological systems, recent work on stimuli-responsive programmable matter has shown great progress...
March 6, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28253193/structural-and-functional-insight-into-pan-endopeptidase-inhibition-by-%C3%AE-2-macroglobulins
#9
Theodoros Goulas, Irene Garcia-Ferrer, Aniebrys Marrero, Laura Marino-Puertas, Stephane Duquerroy, F Xavier Gomis-Rüth
Peptidases must be exquisitely regulated to prevent erroneous cleavage and one control is provided by protein inhibitors. These are usually specific for particular peptidases or families and sterically block the active-site cleft of target enzymes using lock-and-key mechanisms. In contrast, members of the +1400-residue multi-domain α2-macroglobulin inhibitor family (α2Ms) are directed against a broad spectrum of endopeptidases of disparate specificities and catalytic types, and they inhibit their targets without disturbing their active sites...
March 2, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/28243619/a-brief-dataset-on-the-model-based-evaluation-of-the-growth-performance-of-bacillus-coagulans-and-l-lactic-acid-production-in-a-lignin-supplemented-medium
#10
Robert Glaser, Joachim Venus
The data presented in this article are related to the research article entitled "Model-based characterization of growth performance and l-lactic acid production with high optical purity by thermophilic Bacillus coagulans in a lignin-supplemented mixed substrate medium (R. Glaser and J. Venus, 2016) [1]". This data survey provides the information on characterization of three Bacillus coagulans strains. Information on cofermentation of lignocellulose-related sugars in lignin-containing media is given. Basic characterization data are supported by optical-density high-throughput screening and parameter adjustment to logistic growth models...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28236691/nicotine-based-surface-active-ionic-liquids-synthesis-self-assembly-and-cytotoxicity-studies
#11
Gurbir Singh, Raman Kamboj, Venus Singh Mithu, Vinay Chauhan, Taranjeet Kaur, Gurcharan Kaur, Sukhprit Singh, Tejwant Singh Kang
New ester-functionalized surface active ionic liquids (SAILs) based on nicotine, [CnENic][Br] (n=8, 10 and 12), with bromide counterions have been synthesized, characterized and investigated for their self-assembly behavior in aqueous medium. Conductivity measurements in aqueous solutions of the investigated SAILs have provided information about their critical micelle concentration (cmc), and degree of counterion binding (β), where cmc was found to be 2-3-fold lower than homologous SAILs or conventional cationic surfactants...
February 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28228527/activation-mechanism-of-the-g-protein-coupled-sweet-receptor-heterodimer-with-sweeteners-and-allosteric-agonists
#12
Soo-Kyung Kim, Yalu Chen, Ravinder Abrol, William A Goddard, Brian Guthrie
The sweet taste in humans is mediated by the TAS1R2/TAS1R3 G protein-coupled receptor (GPCR), which belongs to the class C family that also includes the metabotropic glutamate and γ-aminobutyric acid receptors. We report here the predicted 3D structure of the full-length TAS1R2/TAS1R3 heterodimer, including the Venus Flytrap Domains (VFDs) [in the closed-open (co) active conformation], the cysteine-rich domains (CRDs), and the transmembrane domains (TMDs) at the TM56/TM56 interface. We observe that binding of agonists to VFD2 of TAS1R2 leads to major conformational changes to form a TM6/TM6 interface between TMDs of TAS1R2 and TAS1R3, which is consistent with the activation process observed biophysically on the metabotropic glutamate receptor 2 homodimer...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28222229/leg-ulcers-caused-by-genetic-disease-prolidase-deficiency
#13
F Bertolini
I have just read the new guidelines for diagnostics and treatment of venus leg ulcers pubblished by the Journal of the European Academy of Dermatology and Venereology, 2016; 30: 1843-1875 (1), and I think that at this time it would be useful to also include leg ulcers caused by genetic disease "prolidase deficiency" in the differential diagnosis. This article is protected by copyright. All rights reserved.
February 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28207991/high-yield-secretion-of-recombinant-proteins-from-the-microalga-chlamydomonas-reinhardtii
#14
E M Ramos-Martinez, L Fimognari, Y Sakuragi
Microalga-based biomanufacturing of recombinant proteins is attracting growing attention due to its advantages in safety, metabolic diversity, scalability, and sustainability. Secretion of recombinant proteins can accelerate the use of microalgal platforms by allowing post-translational modifications and easy recovery of products from the culture media. However, currently, the yields of secreted recombinant proteins are low, which hampers the commercial application of this strategy. This study aimed at expanding the genetic tools for enhancing secretion of recombinant proteins in Chlamydomonas reinhardtii, a widely used green microalga as a model organism and a potential industrial biotechnology platform...
February 16, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28188935/model-based-characterisation-of-growth-performance-and-l-lactic-acid-production-with-high-optical-purity-by-thermophilic-bacillus-coagulans-in-a-lignin-supplemented-mixed-substrate-medium
#15
Robert Glaser, Joachim Venus
Three Bacillus coagulans strains were characterised in terms of their ability to grow in lignin-containing fermentation media and to consume the lignocellulose-related sugars glucose, xylose, and arabinose. An optical-density high-throughput screening was used for precharacterisation by means of different mathematical models for comparison (Logistic, Gompertz, Baranyi, Richards & Stannard, and Schnute). The growth response was characterised by the maximum growth rate and lag time. For a comparison of the screening and fermentation results, an unstructured mathematical model was proposed to characterise the lactate production, bacterial growth and substrate consumption...
February 8, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28179551/olecranon-bursitis-beau-s-lines-biett-s-collarettes-and-crown-of-venus
#16
Walter de Araujo Eyer-Silva, Guilherme Almeida Rosa da Silva, Fernando Raphael de Almeida Ferry
No abstract text is available yet for this article.
February 8, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28149461/microbiological-characterization-and-effect-of-resin-composites-in-cervical-lesions
#17
Bonfanti Carlo, Nicola Barabanti, Giorgio Piccinelli, Vicente Faus-Matoses, Antonio Cerutti
BACKGROUND: Non carious cervical lesions associated to muscle hyperfunctions are increasing. Microhybrid resin composites are used to restore cervical abfractions. The purpose of this study was to investigate if resin composites modify tooth plaque, inducing an increment of cariogenic microflora and evaluate their effect, in vivo and in vitro, against S. mutans. MATERIAL AND METHODS: Eight abfractions were restored with two microhybrid resin composites (Venus, Heraeus-Kulzer® and Esthet-X, Dentsply®), after gnatological therapy, in three patients with muscle hyperfunctions...
January 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28133595/investigation-of-spiral-wound-membrane-modules-for-the-cross-flow-nanofiltration-of-fermentation-broth-obtained-from-a-pilot-plant-fermentation-reactor-for-the-continuous-production-of-lactic-acid
#18
Hendrik Laube, Roland Schneider, Joachim Venus
BACKGROUND: The separation performance of seven polymer membranes for the nanofiltration of sodium lactate in fermentation broth was investigated. Each module was introduced into the test stand, and the system curve was obtained by recording the permeate flow velocity at different pump head levels. Performance benchmarks were good permeate quality, as determined by high permeate flow velocity, high sodium lactic concentration, low ion impurity concentration, and low organic impurity concentration...
2017: Bioresources and Bioprocessing
https://www.readbyqxmd.com/read/28114363/evidence-for-integrin-venus-kinase-receptor-1-alliance-in-the-ovary-of-schistosoma-mansoni-females-controlling-cell-survival
#19
Verena Gelmedin, Marion Morel, Steffen Hahnel, Katia Cailliau, Colette Dissous, Christoph G Grevelding
In metazoan integrin signaling is an important process of mediating extracellular and intracellular communication processes. This can be achieved by cooperation of integrins with growth factor receptors (GFRs). Schistosoma mansoni is a helminth parasite inducing schistosomiasis, an infectious disease of worldwide significance for humans and animals. First studies on schistosome integrins revealed their role in reproductive processes, being involved in spermatogenesis and oogenesis. With respect to the roles of eggs for maintaining the parasite´s life cycle and for inducing the pathology of schistosomiasis, elucidating reproductive processes is of high importance...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28096368/elemental-sulfur-aerosol-forming-mechanism
#20
Manoj Kumar, Joseph S Francisco
Elemental sulfur aerosols are ubiquitous in the atmospheres of Venus, ancient Earth, and Mars. There is now an evolving body of evidence suggesting that these aerosols have also played a role in the evolution of early life on Earth. However, the exact details of their formation mechanism remain an open question. The present theoretical calculations suggest a chemical mechanism that takes advantage of the interaction between sulfur oxides, SOn (n = 1, 2, 3) and hydrogen sulfide (nH2S), resulting in the efficient formation of a Sn+1 particle...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
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