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https://www.readbyqxmd.com/read/28439257/high-resolution-recording-of-the-circadian-oscillator-in-primary-mouse-%C3%AE-and-%C3%AE-cell-culture
#1
Volodymyr Petrenko, Yvan Gosmain, Charna Dibner
Circadian clocks have been developed in evolution as an anticipatory mechanism allowing for adaptation to the constantly changing light environment due to rotation of the Earth. This mechanism is functional in all light-sensitive organisms. There is a considerable body of evidence on the tight connection between the circadian clock and most aspects of physiology and metabolism. Clocks, operative in the pancreatic islets, have caught particular attention in the last years due to recent reports on their critical roles in regulation of insulin secretion and etiology of type 2 diabetes...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28436220/metal-free-organocatalytic-oxidative-ugi-reaction-promoted-by-hypervalent-iodine
#2
Karandeep Singh, Amanpreet Kaur, Venus Singh Mithu, Siddharth Sharma
We report here a novel IBX promoted oxidative coupling of primary amines and its utilization to Ugi reaction. Advantageously, the reaction could be carried out in choline chloride-urea as a natural deep eutectic solvent. A range of imines and bis-amides from pseudo-four component oxidative Ugi reaction could be synthesized under mild and metal-free conditions. Advantageously, the oxidant (IBX) and solvent could be recycled up to five times with only a slight loss in activity.
April 24, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28434287/la-donna-di-ostuni-a-case-of-eclampsia-28-000%C3%A2-years-ago
#3
Pierre-Yves Robillard, Marco Scioscia, Donato Coppola, Jean Chaline, Francesco Bonsante, Silvia Iacobelli
La "Donna di Ostuni", the Lady from Ostuni (fortified medieval city, on the southern Italian Adriatic coast) is the skeleton of "the human most ancient mother" ever found by paleoanthropologists, grave dated of 28,000 years BP. It concerns a 20-years-old woman buried with her baby in her womb estimated at 8 months gestation. To date, the cause of the maternal-fetal deaths is qualified of unknown origin. We propose that eclampsia may be a possible explanation for these deaths (mother and baby together). Eclampsia (convulsions), the curse of human births (non-existent in other mammals), has been described since writings has existed 5000 years ago in all civilisations...
April 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28416693/insect-haptoelectrical-stimulation-of-venus-flytrap-triggers-exocytosis-in-gland-cells
#4
Sönke Scherzer, Lana Shabala, Benjamin Hedrich, Jörg Fromm, Hubert Bauer, Eberhard Munz, Peter Jakob, Khaled A S Al-Rascheid, Ines Kreuzer, Dirk Becker, Monika Eiblmeier, Heinz Rennenberg, Sergey Shabala, Malcolm Bennett, Erwin Neher, Rainer Hedrich
The Venus flytrap Dionaea muscipula captures insects and consumes their flesh. Prey contacting touch-sensitive hairs trigger traveling electrical waves. These action potentials (APs) cause rapid closure of the trap and activate secretory functions of glands, which cover its inner surface. Such prey-induced haptoelectric stimulation activates the touch hormone jasmonate (JA) signaling pathway, which initiates secretion of an acidic hydrolase mixture to decompose the victim and acquire the animal nutrients. Although postulated since Darwin's pioneering studies, these secretory events have not been recorded so far...
April 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28408771/was-venus-the-first-habitable-world-of-our-solar-system
#5
M J Way, Anthony D Del Genio, Nancy Y Kiang, Linda E Sohl, David H Grinspoon, Igor Aleinov, Maxwell Kelley, Thomas Clune
Present-day Venus is an inhospitable place with surface temperatures approaching 750K and an atmosphere 90 times as thick as Earth's. Billions of years ago the picture may have been very different. We have created a suite of 3-D climate simulations using topographic data from the Magellan mission, solar spectral irradiance estimates for 2.9 and 0.715 Gya, present-day Venus orbital parameters, an ocean volume consistent with current theory, and an atmospheric composition estimated for early Venus. Using these parameters we find that such a world could have had moderate temperatures if Venus had a rotation period slower than ~16 Earth days, despite an incident solar flux 46-70% higher than Earth receives...
August 28, 2016: Geophysical Research Letters
https://www.readbyqxmd.com/read/28402737/comparison-of-polymerization-shrinkage-physical-properties-and-marginal-adaptation-of-flowable-and-restorative-bulk-fill-resin-based-composites
#6
J H Jung, S H Park
PURPOSE: The purpose of this study was to compare the marginal adaptation of two flowable bulk fill resin-based composites (FB-RBCs), two restorative bulk fill resin-based composites (RB-RBCs), and one regular incremental-fill RBC in MOD cavities in vitro. Additionally, the influence of linear polymerization shrinkage, shrinkage force, flexural modulus, and bottom/top surface hardness ratio on the marginal adaptation was evaluated. METHODS: A Class II MOD cavity was prepared in 40 extracted sound lower molars...
April 12, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28400455/venus
#7
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Family Planning and Reproductive Health Care
https://www.readbyqxmd.com/read/28387033/non-invasive-measurement-of-right-atrial-pressure-by-near-infrared-spectroscopy-preliminary-experience-a-report-from-the-sica-hf-study
#8
Pierpaolo Pellicori, Andrew L Clark, Anna Kallvikbacka-Bennett, Jufen Zhang, Alessia Urbinati, Luca Monzo, Riet Dierckx, Stefan D Anker, John G F Cleland
AIMS: To assess the clinical value of measuring right atrial pressure (RAP) using near-infrared spectroscopy (NIRS) in patients with chronic heart failure (CHF). METHODS AND RESULTS: RAP was measured non-invasively using NIRS over the external jugular vein (Venus 1000, Mespere LifeSciences, Canada) in ambulatory patients with CHF enrolled in the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF) programme. Comparing 243 patients with CHF (mean age 71 years; mean left ventricular ejection fraction (LVEF) 45%, median NT-proBNP 788 ng/L) to 49 controls (NT-proBNP ≤125 ng/L), RAP was 7 [interquartile range (IQR) 4-11] mmHg vs...
April 6, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28384187/target-localization-of-3d-versus-4d-cone-beam-computed-tomography-in-lipiodol-guided-stereotactic-radiotherapy-of-hepatocellular-carcinomas
#9
Mark Chan, Chi Leung Chiang, Venus Lee, Steven Cheung, Ronnie Leung, Matthew Wong, Frankle Lee, Oliver Blanck
BACKGROUND: Aim of this study was to comparatively evaluate the accuracy of respiration-correlated (4D) and uncorrelated (3D) cone beam computed tomography (CBCT) in localizing lipiodolized hepatocellular carcinomas during stereotactic body radiotherapy (SBRT). METHODS: 4D-CBCT scans of eighteen HCCs were acquired during free-breathing SBRT following trans-arterial chemo-embolization (TACE) with lipiodol. Approximately 1320 x-ray projections per 4D-CBCT were collected and phase-sorted into ten bins...
2017: PloS One
https://www.readbyqxmd.com/read/28380590/global-differential-gene-expression-in-the-pituitary-gland-and-the-ovaries-of-pre-and-postpubertal-brahman-heifers
#10
L T Nguyen, A Reverter, A Cánovas, B Venus, A Islas-Trejo, L R Porto-Neto, S A Lehnert, J F Medrano, S S Moore, M R S Fortes
To understand genes, pathways, and networks related to puberty, we characterized the transcriptome of two tissues: the pituitary gland and ovaries. Samples were harvested from pre- and postpubertal Brahman heifers (same age group). Brahman heifers () are older at puberty compared with , a productivity issue. With RNA sequencing, we identified differentially expressed (DEx) genes and important transcription factors (TF) and predicted coexpression networks. The number of DEx genes detected in the pituitary gland was 284 ( < 0...
February 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28371195/intratumoral-bidirectional-transitions-between-epithelial-and-mesenchymal-cells-in-triple-negative-breast-cancer
#11
Mizuki Yamamoto, Kota Sakane, Kana Tominaga, Noriko Gotoh, Takayoshi Niwa, Yasuko Kikuchi, Keiichiro Tada, Naoki Goshima, Kentaro Semba, Jun-Ichiro Inoue
Epithelial-mesenchymal transition (EMT) and its reverse process, MET, are crucial in several stages of cancer metastasis. EMT allows cancer cells to move to proximal blood vessels for intravasation. However, because EMT and MET processes are dynamic, mesenchymal cancer cells are likely to undergo MET transiently and subsequently re-undergo EMT to restart the metastatic process. Therefore, spatiotemporally-coordinated mutual regulation between EMT and MET could occur during metastasis. To elucidate such regulation, we chose HCC38, a human triple-negative breast cancer cell line, because HCC38 is composed of epithelial and mesenchymal populations at a fixed ratio even though mesenchymal cells proliferate significantly more slowly than epithelial cells...
April 1, 2017: Cancer Science
https://www.readbyqxmd.com/read/28355553/deciphering-camkii-multimerization-using-fluorescence-correlation-spectroscopy-and-homo-fret-analysis
#12
Pabak Sarkar, Kaitlin A Davis, Henry L Puhl, Jithesh V Veetil, Tuan A Nguyen, Steven S Vogel
While kinases are typically composed of one or two subunits, calcium-calmodulin (CaM)-dependent protein kinase II (CaMKII) is composed of 8-14 subunits arranged as pairs around a central core. It is not clear if the CaMKII holoenzyme functions as an assembly of independent subunits, as catalytic pairs, or as a single unit. One strategy to address this question is to genetically engineer monomeric and dimeric CaMKII and evaluate how their activity compares to the wild-type (WT) holoenzyme. Here a technique that combines fluorescence correlation spectroscopy and homo-FRET analysis was used to characterize assembly mutants of Venus-tagged CaMKIIα to identify a dimeric CaMKII...
March 28, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28340271/snp-detection-using-rna-sequences-of-candidate-genes-associated-with-puberty-in-cattle
#13
M M Dias, A Cánovas, C Mantilla-Rojas, D G Riley, P Luna-Nevarez, S J Coleman, S E Speidel, R M Enns, A Islas-Trejo, J F Medrano, S S Moore, M R S Fortes, L T Nguyen, B Venus, I S D P Diaz, F R P Souza, L F S Fonseca, F Baldi, L G Albuquerque, M G Thomas, H N Oliveira
Fertility traits, such as heifer pregnancy, are economically important in cattle production systems, and are therefore, used in genetic selection programs. The aim of this study was to identify single nucleotide polymorphisms (SNPs) using RNA-sequencing (RNA-Seq) data from ovary, uterus, endometrium, pituitary gland, hypothalamus, liver, longissimus dorsi muscle, and adipose tissue in 62 candidate genes associated with heifer puberty in cattle. RNA-Seq reads were assembled to the bovine reference genome (UMD 3...
March 22, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28335403/comparison-of-faunal-scavenging-of-submerged-carrion-in-two-seasons-at-a-depth-of-170-m-in-the-strait-of-georgia-british-columbia
#14
Gail S Anderson, Lynne S Bell
The taphonomy of carcasses submerged in the ocean is little understood, yet it is extremely important ecologically and forensically. The objectives of this study were to determine the fate of pig carcasses as human proxies in the Strait of Georgia at 170 m in spring and fall. Using Ocean Networks Canada's Victoria Experimental Network Underseas (VENUS) observatory, two carcasses per season were placed under a cabled platform hosting a webcam and instruments measuring water chemistry. Two minutes of video were recorded every 15 min...
March 13, 2017: Insects
https://www.readbyqxmd.com/read/28333405/use-of-nanofractional-radiofrequency-for-the-treatment-of-acne-scars-in-indian-skin
#15
Apratim Goel, Vallari Gatne
BACKGROUND: Pitted acne scars of all types remain notoriously challenging to treat with no satisfactory treatment modality, particularly true for darker Fitzpatrick skin types such as Indian skin. AIM: Nanofractional radiofrequency has been shown to be an effective treatment modality for the cosmetic improvement of acne scars. METHODS: Twenty healthy male and female Indian patients aged 16-60 years with Fitzpatrick skin types IV-V and moderate-to-severe acne scar lesions received 1-3 treatments with a nanofractional radiofrequency device (Venus Viva) at baseline and at 3- to 6 week intervals and were evaluated with photographs at each treatment visit and up to 6 months after the final treatment session...
March 23, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28326089/dynamic-regulation-of-auxin-response-during-rice-development-revealed-by-newly-established-hormone-biosensor-markers
#16
Jing Yang, Zheng Yuan, Qingcai Meng, Guoqiang Huang, Christophe Périn, Charlotte Bureau, Anne-Cécile Meunier, Mathieu Ingouff, Malcolm J Bennett, Wanqi Liang, Dabing Zhang
The hormone auxin is critical for many plant developmental processes. Unlike the model eudicot plant Arabidopsis (Arabidopsis thaliana), auxin distribution and signaling in rice tissues has not been systematically investigated due to the absence of suitable auxin response reporters. In this study we observed the conservation of auxin signaling components between Arabidopsis and model monocot crop rice (Oryza sativa), and generated complementary types of auxin biosensor constructs, one derived from the Aux/IAA-based biosensor DII-VENUS but constitutively driven by maize ubiquitin-1 promoter, and the other termed DR5-VENUS in which a synthetic auxin-responsive promoter (DR5rev ) was used to drive expression of the yellow fluorescent protein (YFP)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28323850/ligand-guided-homology-modelling-of-the-gabab2-subunit-of-the-gabab-receptor
#17
Thibaud Freyd, Dawid Warszycki, Stefan Mordalski, Andrzej J Bojarski, Ingebrigt Sylte, Mari Gabrielsen
γ-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, and disturbances in the GABAergic system have been implicated in numerous neurological and neuropsychiatric diseases. The GABAB receptor is a heterodimeric class C G protein-coupled receptor (GPCR) consisting of GABAB1a/b and GABAB2 subunits. Two GABAB receptor ligand binding sites have been described, namely the orthosteric GABA binding site located in the extracellular GABAB1 Venus fly trap domain and the allosteric binding site found in the GABAB2 transmembrane domain...
2017: PloS One
https://www.readbyqxmd.com/read/28322324/high-temperature-near-field-nanothermomechanical-rectification
#18
Mahmoud Elzouka, Sidy Ndao
Limited performance and reliability of electronic devices at extreme temperatures, intensive electromagnetic fields, and radiation found in space exploration missions (i.e., Venus &Jupiter planetary exploration, and heliophysics missions) and earth-based applications requires the development of alternative computing technologies. In the pursuit of alternative technologies, research efforts have looked into developing thermal memory and logic devices that use heat instead of electricity to perform computations...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28318133/transcatheter-aortic-valve-implantation-with-the-self-expandable-venus-a-valve-and-corevalve-devices-preliminary-experiences-in-china
#19
COMPARATIVE STUDY
Yan-Biao Liao, Zhen-Gang Zhao, Xin Wei, Yuan-Ning Xu, Zhi-Liang Zuo, Yi-Jian Li, Ming-Xia Zheng, Yuan Feng, Mao Chen
BACKGROUND: Transcatheter aortic valve implantation (TAVI) has been demonstrated to be an effective alternative to surgical aortic valve replacement (SAVR) in patients with aortic stenosis who are deemed high risk or inoperable. Currently, TAVI procedures in China mostly make use of the domestic Venus A-Valve and the CoreValve; however, there is no data on their comparative performance. METHODS: Consecutive patients undergoing TAVI with the aforementioned devices were included...
March 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28288001/programmable-snapping-composites-with-bio-inspired-architecture
#20
Jascha U Schmied, Hortense Le Ferrand, Paolo Ermanni, André R Studart, Andres F Arrieta
The development of programmable self-shaping materials enables the onset of new and innovative functionalities in many application fields. Commonly, shape adaptation is achieved by exploiting diffusion-driven swelling or nano-scale phase transition, limiting the change of shape to slow motion predominantly determined by the environmental conditions and/or the materials specificity. To address these shortcomings, we report shape adaptable programmable shells that undergo morphing via a snap-through mechanism inspired by the Dionaea muscipula leaf, known as the Venus fly trap...
March 13, 2017: Bioinspiration & Biomimetics
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