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"essential tremor"

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https://www.readbyqxmd.com/read/29456897/detection-of-essential-tremor-at-the-formula-see-text-band
#1
Xiaodong Yang, Syed Aziz Shah, Aifeng Ren, Dou Fan, Nan Zhao, Dongjian Cao, Fangming Hu, Masood Ur Rehman, Weigang Wang, Karen M Von Deneen, Jie Tian
Essential tremor (ET) is a neurological disorder characterized by rhythmic, involuntary shaking of a part or parts of the body. The most common tremor is seen in the hands/arms and fingers. This paper presents an evaluation of ETs monitoring based on finger-to-nose test measurement as captured by small wireless devices working in shortwave or [Formula: see text]-band frequency range. The acquired signals in terms of amplitude and phase information are used to detect a tremor in the hands. Linearly transforming raw phase data acquired in the [Formula: see text]-band were carried out for calibrating the phase information and to improve accuracy...
2018: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29445332/motor-unit-action-potential-clustering-theoretical-consideration-for-muscle-activation-during-a-motor-task
#2
Michael J Asmussen, Vinzenz von Tscharner, Benno M Nigg
During dynamic or sustained isometric contractions, bursts of muscle activity appear in the electromyography (EMG) signal. Theoretically, these bursts of activity likely occur because motor units are constrained to fire temporally close to one another and thus the impulses are "clustered" with short delays to elicit bursts of muscle activity. The purpose of this study was to investigate whether a sequence comprised of "clustered" motor unit action potentials (MUAP) can explain spectral and amplitude changes of the EMG during a simulated motor task...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29438045/double-target-dbs-for-essential-tremor-8-contact-lead-for-czi-and-vim-aligned-in-the-same-trajectory
#3
Maria Gabriela Dos Santos Ghilardi, Melisa Ibarra, Eduardo J L Alho, Paul Rodrigo Reis, William Omar Lopez Contreras, Clement Hamani, Erich Talamoni Fonoff
No abstract text is available yet for this article.
February 7, 2018: Neurology
https://www.readbyqxmd.com/read/29437013/topiramate-induced-limbs-paraesthesia-and-rigid-fingers-flexion
#4
Andrea Domenico Pratico, Martino Ruggieri, Raffaele Falsaperla, Piero Pavone
Topiramate is a well-known anticonvulsant drug with a broad spectrum of actions. It has been proposed in the treatment of several types of epileptic seizures both in monotherapy and in add-on. Its usage has been extended to other disorders including migraine, essential tremor, obesity, alcohol and drug addiction. The most frequent side-effects of topiramate include dizziness, somnolence, insomnia, and ataxia. Paraesthesia, metabolic acidosis, kidney stones, hypohidrosis, cognitive impairment and eye symptoms have been also reported...
February 12, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29434571/knowledge-about-essential-tremor-a-study-of-essential-tremor-families
#5
Ashley D Cristal, Karen P Chen, Nora Cristina Hernandez, Pam Factor-Litvak, Lorraine N Clark, Ruth Ottman, Elan D Louis
Background: Essential tremor (ET) is among the most common neurological diseases and it often runs in families. How knowledgeable ET patients and their families are about their disease has been the subject of surprisingly little scholarship. Methods: To fill this gap in knowledge, we administered a comprehensive 32-item survey (i.e., questions about etiology, pathophysiology, symptoms and signs, natural history, and treatments) to 427 participants, including 76 ET probands, 74 affected relatives (AFRs), 238 unaffected relatives, and 39 spouses of unaffected relatives, all of whom were participating in two ET family studies...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29433124/thalamic-deep-brain-stimulation-salvages-failed-focused-ultrasound-thalamotomy-for-essential-tremor-a-case-report
#6
Tony R Wang, Robert F Dallapiazza, Shayan Moosa, Diane Huss, Binit B Shah, W Jeffrey Elias
BACKGROUND: A recent randomized controlled trial investigating unilateral MRI-guided focused ultrasound (FUS) for essential tremor demonstrated efficacy. The long-term durability of this thalamotomy, however, is unknown. Furthermore, the feasibility of stimulating a previously lesioned target such as the thalamic nucleus ventralis intermedius (Vim) is poorly understood. We report a case of tremor recurrence, following an initially successful FUS thalamotomy, in which Vim-DBS was subsequently utilized to regain tremor control...
February 12, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29433116/-mr-guided-focused-ultrasound
#7
Hideki Mochizuki, Noriaki Hattori
Since the middle of the 20th century and in order to treat neurological diseases, clinicians have proposed the use of ultrasound, instead of skin incision or trepanation, when performing intracranial thermocoagulation. However, focusing ultrasound intracranially with high precision was technically difficult until recent technological developments. Specifically, advancements in ultrasound phased-array transducers have eliminated the need for a craniotomy, and progress in magnetic resonance (MR) imaging has allowed the real-time measurement of intracranial temperature...
February 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29431985/tremor-sorting-through-the-differential-diagnosis
#8
Paul Crawford, Ethan E Zimmerman
Tremor is an involuntary, rhythmic, oscillatory movement of a body part. It is the most common movement disorder encountered in primary care. The diagnosis of tremor is based on clinical information obtained from the history and physical examination. The most common tremors in patients presenting to primary care physicians are enhanced physiologic tremor, essential tremor, and parkinsonian tremor. All persons have low-amplitude, high-frequency physiologic tremors at rest and during action that are not reported as symptomatic, but can be enhanced by anxiety, medication use, caffeine intake, or fatigue...
February 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29431884/successes-and-optimism-in-deep-brain-stimulation-for-neurological-disorders-ripe-for-a-surgical-time-out
#9
Alexander I Tröster
In the USA, the Food and Drug Administration (FDA) has approved deep brain stimulation (DBS) devices for the treatment of Parkinson's disease (PD), essential tremor (ET), dystonia, and obsessive compulsive disorder (OCD). DBS has been approved for these same conditions in Europe, but, additionally the European Commission (EC) has granted the Conformité Européenne (CE) Mark for DBS as adjunctive treatment for partial-onset seizures in adults with medically refractory epilepsy. In this issue of EJN Budman and colleagues [1] briefly review the range of neurologic conditions that might constitute promising new indications for DBS...
February 12, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29428341/a-method-for-characterizing-essential-tremor-from-the-shoulder-to-the-wrist
#10
Daniel W Geiger, Dennis L Eggett, Steven K Charles
BACKGROUND: Despite the pervasive and devastating effect of Essential Tremor (ET), the distribution of ET throughout the upper limb is unknown. We developed a method for characterizing the distribution of ET and performed a preliminary characterization in a small number of subjects with ET. METHODS: Using orientation sensors and inverse kinematics, we measured tremor in each of the seven major degrees of freedom (DOF) from the shoulder to the wrist while ten patients with mild ET assumed 16 different postures...
January 3, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29419349/autophagy-precedes-apoptosis-among-at-risk-cerebellar-purkinje-cells-in-the-shaker-mutant-rat-an-ultrastructural-study
#11
Nour S Erekat
Cerebellar Purkinje cell (PC) death has been shown to occur in essential tremor, ataxia, and many other neurodegenerative diseases in humans. Shaker mutant rats have an X-linked recessive mutation that causes hereditary degeneration of "at risk" cerebellar PCs. This defect can occur in the restricted anterior (ADC) and posterior (PDC) vermal degeneration compartments postnatally within 7 to 14 weeks of age as a natural phenotype in the shaker mutant rat. "Secure" PCs persist in a flocculonodular survival compartment (FNSC)...
February 8, 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29419328/brain-focused-ultrasound-what-s-the-fus-all-about-a-review-of-current-and-emerging-neurological-applications
#12
Laure Bretsztajn, Wladyslaw Gedroyc
Magnetic resonance-guided focused ultrasound surgery (MRgFUS) allows for precise non-invasive thermal ablation of target tissues for a wide range of clinical applications. It is an innovative and rapidly expanding technology which has already established itself as an effective and safe incisionless alternative in the treatment of various soft tissue tumours, with many more research studies underway to extend its therapeutic envelope. The non-invasiveness of the procedure makes FUS particularly attractive in functional neurosurgery, where existing treatment options are not suitable for all patients...
February 8, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29414403/postoperative-rehabilitation-after-deep-brain-stimulation-surgery-for-movement-disorders
#13
REVIEW
Niels Allert, Binith Cheeran, Günther Deuschl, Michael T Barbe, Ilona Csoti, Markus Ebke, Martin Glaser, Jun-Suk Kang, Stefan Kelm, Paul Krack, Julia Kroth, Ulrich Jobst, Markus Leisse, Antonio Oliviero, Peter Nikolaus Nolte, Johanna Quick-Weller, Martin Strothjohann, Gertrúd Tamás, Michael Werner, Muthuraman Muthuraman, Jens Volkmann, Alfonso Fasano, Sergiu Groppa
Deep brain stimulation (DBS) is a highly efficient, evidence-based therapy for a set of neurological and psychiatric conditions and especially movement disorders such as Parkinson's disease, essential tremor and dystonia. Recent developments have improved the DBS technology. However, no unequivocal algorithms for an optimized postoperative care exist so far. The aim of this review is to provide a synopsis of the current clinical practice and to propose guidelines for postoperative and rehabilitative care of patients who undergo DBS...
January 10, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29410136/pretherapeutic-functional-imaging-allows-prediction-of-head-tremor-arrest-after-thalamotomy-for-essential-tremor-the-role-of-altered-interconnectivity-between-thalamolimbic-and-supplementary-motor-circuits
#14
Constantin Tuleasca, Jean Régis, Elena Najdenovska, Tatiana Witjas, Nadine Girard, Jérôme Champoudry, Mohamed Faouzi, Jean-Philippe Thiran, Meritxell Bach Cuadra, Marc Levivier, Dimitri Van De Ville
OBJECTIVE: To correlate pretherapeutic resting-state functional MRI (rs-fMRI) measures with pretherapeutic head tremor presence and/or further improvement 1 year after stereotactic radiosurgical thalamotomy (SRS-T) for essential tremor (ET). METHODS: We prospectively collected head tremor scores (range 0-3) and rs-fMRI data for a cohort of 17 consecutive ET patients in pretherapeutic and 1 year after SRS-T states. We additionally acquired rs-fMRI data for a healthy control (HC) group (n=12)...
January 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29406890/shaky-and-unsteady-dynamic-posturography-in-essential-tremor
#15
Shweta Prasad, Selva Ganapathy Velayutham, Venkateswara Reddy Reddam, Albert Stezin, Ketan Jhunjhunwala, Pramod Kumar Pal
BACKGROUND: The spectrum of symptoms exhibited by patients with essential tremor (ET) extends far beyond the classical tremor. This study aims to explore and establish the presence of subtle balance abnormalities in ET using dynamic posturography (DP). METHODS: DP was performed on 18 patients with ET and 26 controls. Diagnosis of ET was based on the Consensus Statement of the Movement Disorder Society on Tremor. Dynamic stability which included the overall balance index, anterior-posterior index and mediolateral index, and limits of stability were measured...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29406415/magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-applications-in-pediatrics-early-experience-at-children-s-national-medical-center
#16
Karun V Sharma, Pavel S Yarmolenko, Avinash Eranki, Ari Partanen, Haydar Celik, AeRang Kim, Matthew Oetgen, Peter C W Kim
Magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) is a novel technology that integrates magnetic resonance imaging with therapeutic ultrasound. This unique approach provides a completely noninvasive method for precise thermal ablation of targeted tissues with real-time imaging feedback. Over the past 2 decades, MR-HIFU has shown clinical success in several adult applications ranging from treatment of painful bone metastases to uterine fibroids to prostate cancer and essential tremor...
February 2018: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/29404647/-essential-tremor-state-of-the-art
#17
REVIEW
G Deuschl, D Berg
Essential tremor (ET) is currently classified as a syndrome rather than a unique disease, primarily involving monosymptomatic action tremor in both hands. Different etiologies are presumed to underlie this condition. Currently only a few monogenetic conditions are known to present with this syndrome. If accompanied by additional symptoms that do not in themselves constitute a new syndrome, such as abnormal tandem gait or postures, the syndrome should be diagnosed as "ET plus". ET is associated with abnormal rhythmic activation of the cerebello-thalamo-cortical tremor circuit...
February 5, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29402567/dysgeusia-in-deep-brain-stimulation-for-essential-tremor
#18
Jonathan Dennis Carlson, Kate Elizabeth McLeod, Jamelyn Brooke Mark, Pamela Sue McLeod, Beth Ann Bremer
Dysgeusia, or foul taste, is a rarely reported side effect in patients who have undergone deep brain stimulation (DBS) in the thalamus for essential tremor. This retrospective study evaluated the incidence, nature, neurophysiological and anatomical location of dysgeusia following DBS. Of 52 patients who had undergone DBS for essential tremor, eight (15%) reported dysgeusia, which was described as a "metallic," "sour," "foul," or "cold" taste in the mouth. Dysgeusia was separate and distinguishable from paresthesia...
February 2, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29398123/association-study-of-essential-tremor-genetic-loci-in-parkinson-s-disease
#19
Jay P Ross, Sadaf Mohtashami, Etienne Leveille, Amelie M Johnson, Lan Xiong, Patrick A Dion, Edward Fon, Yves Dauvilliers, Nicolas Dupré, Guy A Rouleau, Ziv Gan-Or
A recent genome-wide association study identified variants associated with essential tremor (ET). The present study aimed to examine potential genetic overlap between ET and Parkinson's disease (PD). The top 22 variants identified by the ET genome-wide association study and 4 additional variants from previous studies were genotyped in a cohort of French and French-Canadian PD patients (n = 717) and controls (n = 595). Logistic regression analysis, adjusted for age and sex, was used to test for association between genotype and PD...
January 6, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29394144/high-intensity-focused-ultrasound-for-pain-management-in-patients-with-cancer
#20
Susan Dababou, Cristina Marrocchio, Roberto Scipione, Hans-Peter Erasmus, Pejman Ghanouni, Michele Anzidei, Carlo Catalano, Alessandro Napoli
Cancer-related pain affects up to 80% of patients with malignancies. Pain is an important distressing symptom that diminishes the quality of life and negatively affects the survival of patients. Opioid analgesics are generally the primary therapy for cancer-related pain, with surgery, radiation therapy, chemotherapy, and other interventions used in cases of treatment-resistant pain. These treatments, which can be associated with substantial side effects and systemic toxicity, may not be effective. High-intensity focused ultrasound is an entirely noninvasive technique that is approved for treatment of uterine fibroids, bone metastases, and essential tremors...
January 30, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
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