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https://www.readbyqxmd.com/read/29206482/brain-circuits-and-neurochemical-systems-in-essential-tremor-insights-into-current-and-future-pharmacotherapeutic-approaches
#1
Sara M Schaefer, Ana Vives Rodriguez, Elan D Louis
There are few medications that are available for the treatment of essential tremor (ET) and they are only moderately effective. Areas covered: Data were obtained from a PubMed search. Original articles, review articles, and clinical guidelines were included. Two disease models for ET have been proposed: 1) the olivary model, which attributes ET to a pathological pacemaker in the inferior olivary nucleus, and 2) the cerebellar degeneration model, which postulates that ET originates in the cerebellum and could be related to deficient or abnormal Purkinje cell (PC) output...
December 5, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29204315/pathogenesis-of-primary-orthostatic-tremor-current-concepts-and-controversies
#2
REVIEW
Abhishek Lenka, Pramod Kumar Pal, Danish Ejaz Bhatti, Elan D Louis
Background: Orthostatic tremor (OT), a rare and complex movement disorder, is characterized by rapid tremor of both legs and the trunk while standing. These disappear while the patient is either lying down or walking. OT may be idiopathic/primary or it may coexist with several neurological conditions (secondary OT/OT plus). Primary OT remains an enigmatic movement disorder and its pathogenesis and neural correlates are not fully understood. Methods: A PubMed search was conducted in July 2017 to identify articles for this review...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/29203059/increased-glutamate%C3%A2-glutamine-levels-in-the-thalamus-of-patients-with-essential-tremor-a-preliminary-proton-mr-spectroscopic-study
#3
Gaetano Barbagallo, Gennarina Arabia, Fabiana Novellino, Rita Nisticò, Maria Salsone, Maurizio Morelli, Federico Rocca, Andrea Quattrone, Manuela Caracciolo, Umberto Sabatini, Andrea Cherubini, Aldo Quattrone
INTRODUCTION: The aim of this study was to investigate the thalamic biochemical profile in patients with essential tremor (ET), using proton magnetic resonance spectroscopy (1H-MRS), and to explore the correlations between clinical and biochemical data. METHODS: Sixteen patients with ET and 14 healthy controls participated in this study. After conventional MR imaging, single-voxel 1H-MRS (TR = 2000 ms; TE = 28 ms) was performed by using a PROBE-SV system implemented on a 3-T scanner...
November 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29196249/deep-brain-stimulation-for-essential-tremor-a-comparison-of-targets
#4
Joost A H Holslag, Nienke Neef, Martijn Beudel, Gea Drost, D L Marinus Oterdoom, Naomi I Kremer, Teus van Laar, J Marc C van Dijk
INTRODUCTION: Deep Brain Stimulation (DBS) is an established treatment for refractory Essential Tremor (ET). Initially, the target of choice was the thalamic Ventral Inter Mediate nucleus (VIM). However, the Zona Incerta (ZI) has been put forward as a superior target. Both targets are considered safe and effective, but a direct comparison between these targets is lacking. METHODS: We analyzed a single-center cohort of 44 ET-patients treated with DBS between 1998 and 2017, targeting the VIM and/or ZI...
November 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29193359/consensus-statement-on-the-classification-of-tremors-from-the-task-force-on-tremor-of-the-international-parkinson-and-movement-disorder-society
#5
Kailash P Bhatia, Peter Bain, Nin Bajaj, Rodger J Elble, Mark Hallett, Elan D Louis, Jan Raethjen, Maria Stamelou, Claudia M Testa, Guenther Deuschl
BACKGROUND: Consensus criteria for classifying tremor disorders were published by the International Parkinson and Movement Disorder Society in 1998. Subsequent advances with regard to essential tremor, tremor associated with dystonia, and other monosymptomatic and indeterminate tremors make a significant revision necessary. OBJECTIVES: Convene an international panel of experienced investigators to review the definition and classification of tremor. METHODS: Computerized MEDLINE searches in January 2013 and 2015 were conducted using a combination of text words and MeSH terms: "tremor", "tremor disorders", "essential tremor", "dystonic tremor", and "classification" limited to human studies...
November 30, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29191439/effects-of-cerebellar-neuromodulation-in-movement-disorders-a%C3%A2-systematic-review
#6
REVIEW
Carina França, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Ricardo Galhardoni, Valquiria Silva, Egberto Reis Barbosa, Rubens Gisbert Cury
BACKGROUND: The cerebellum is involved in the pathophysiology of many movement disorders and its importance in the field of neuromodulation is growing. OBJECTIVES: To review the current evidence for cerebellar modulation in movement disorders and its safety profile. METHODS: Eligible studies were identified after a systematic literature review of the effects of cerebellar modulation in cerebellar ataxia, Parkinson's disease (PD), essential tremor (ET), dystonia and progressive supranuclear palsy (PSP)...
November 23, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29177497/a-simple-way-to-distinguish-essential-tremor-from-tremulous-parkinson-s-disease
#7
Marie Vidailhet, Emmanuel Roze, Hyder A Jinnah
No abstract text is available yet for this article.
July 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29164011/dat-s-awesome-hawai-i-s-first-dopamine-transporter-dat-nuclear-medicine-study
#8
Eric J Royston, Yang-En Kao, Kevin M Nakamura
Parkinsonian Syndromes are difficult to accurately diagnose and distinguish from other neurological processes such as essential tremor. Until now, physical exam and clinical presentation have been the gold standard for diagnosis (bradykinesia, tremor, rigidity, and postural instability).1 However, this leads to over- or under diagnosis and improper treatment due to variability in presentation and symptoms.1 A nuclear medicine study using I-123 Ioflupane (DaTSCAN) has been developed, which allows accurate differentiation of Parkinsonian Syndromes from other etiologies...
November 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/29157315/botulinum-toxin-type-a-injections-as-monotherapy-for-upper-limb-essential-tremor-using-kinematics
#9
Olivia Samotus, Niraj Kumar, Philippe Rizek, Mandar Jog
BACKGROUND: There is a significant need for a targeted therapy for essential tremor (ET), as medications have not been developed specifically for ET, and the ones prescribed are often not well-tolerated, so that many patients remain untreated. Recent work has shown that, unlike previous experience, kinematically guided individualized botulinum toxin type A (BoNT-A) injections provide benefit along with minimal weakness. Ours is the first long-term (96-week) safety and efficacy study of BoNT-A as monotherapy for ET using kinematically driven injection parameters...
November 21, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29133699/referral-practice-reporting-standards-and-the-impact-of-dopamine-transporter-scans-done-in-a-tertiary-hospital
#10
Shakya Bhattacharjee, Albi J Chalissery, Tim Barry, Donagh O'Sullivan, Martin O'Connell, Timothy Lynch
AIMS: We studied the referral practice, reporting standards, and the impact of 123 ioflupane single photon emission computed tomogram dopamine transporters (DAT-SPECT) scans conducted for the diagnosis and clinical management of patients. SETTINGS AND DESIGNS: The present study was a retrospective, non-interventional study. MATERIALS AND METHODS: We assessed the DAT scan referral and the official reports available from the Nuclear Medicine Department of the Mater Misericordiae University Hospital over 1 year (2013)...
November 2017: Neurology India
https://www.readbyqxmd.com/read/29128955/right-brodmann-area-18-predicts-tremor-arrest-after-vim-radiosurgery-a-voxel-based-morphometry-study
#11
Constantin Tuleasca, Tatiana Witjas, Dimitri Van de Ville, Elena Najdenovska, Antoine Verger, Nadine Girard, Jerome Champoudry, Jean-Philippe Thiran, Meritxell Bach Cuadra, Marc Levivier, Eric Guedj, Jean Régis
INTRODUCTION: Drug-resistant essential tremor (ET) can benefit from open standard stereotactic procedures, such as deep-brain stimulation or radiofrequency thalamotomy. Non-surgical candidates can be offered either high-focused ultrasound (HIFU) or radiosurgery (RS). All procedures aim to target the same thalamic site, the ventro-intermediate nucleus (e.g., Vim). The mechanisms by which tremor stops after Vim RS or HIFU remain unknown. We used voxel-based morphometry (VBM) on pretherapeutic neuroimaging data and assessed which anatomical site would best correlate with tremor arrest 1 year after Vim RS...
November 11, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29126946/sensory-percepts-induced-by-microwire-array-and-dbs-microstimulation-in-human-sensory-thalamus
#12
Brandon D Swan, Lynne B Gasperson, Max O Krucoff, Warren M Grill, Dennis A Turner
BACKGROUND: Microstimulation in human sensory thalamus (ventrocaudal, VC) results in focal sensory percepts in the hand and arm which may provide an alternative target site (to somatosensory cortex) for the input of prosthetic sensory information. Sensory feedback to facilitate motor function may require simultaneous or timed responses across separate digits to recreate perceptions of slip as well as encoding of intensity variations in pressure or touch. OBJECTIVES: To determine the feasibility of evoking sensory percepts on separate digits with variable intensity through either a microwire array or deep brain stimulation (DBS) electrode, recreating "natural" and scalable percepts relating to the arm and hand...
October 27, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29125566/botulinum-toxin-in-management-of-limb-tremor
#13
REVIEW
Elina Zakin, David Simpson
Essential tremor is characterized by persistent, usually bilateral and symmetric, postural or kinetic activation of agonist and antagonist muscles involving either the distal or proximal upper extremity. Quality of life is often affected and one's ability to perform daily tasks becomes impaired. Oral therapies, including propranolol and primidone, can be effective in the management of essential tremor, although adverse effects can limit their use and about 50% of individuals lack response to oral pharmacotherapy...
November 10, 2017: Toxins
https://www.readbyqxmd.com/read/29125416/gamma-oscillations-in-the-somatosensory-thalamus-of-a-patient-with-a-phantom-limb-case-report
#14
Diellor Basha, Jonathan O Dostrovsky, Suneil K Kalia, Mojgan Hodaie, Andres M Lozano, William D Hutchison
The amputation of an extremity is commonly followed by phantom sensations that are perceived to originate from the missing limb. The mechanism underlying the generation of these sensations is still not clear although the development of abnormal oscillatory bursting in thalamic neurons may be involved. The theory of thalamocortical dysrhythmia implicates gamma oscillations in phantom pathophysiology although this rhythm has not been previously observed in the phantom limb thalamus. In this study, the authors report the novel observation of widespread 38-Hz gamma oscillatory activity in spike and local field potential recordings obtained from the ventral caudal somatosensory nucleus of the thalamus (Vc) of a phantom limb patient undergoing deep brain stimulation (DBS) surgery...
November 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29109210/essential-tremor
#15
Graeme Schwindt, Jeremy Rezmovitz
No abstract text is available yet for this article.
November 6, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29103291/current-and-future-uses-of-transcranial-focused-ultrasound-in-neurosurgery
#16
David S Hersh, Howard M Eisenberg
Focused ultrasound (FUS) produces a region of high intensity at the focal zone of the beam but with minimal effects at adjacent areas, allowing the sonication of deep targets throughout the body. Despite early obstacles to transmitting ultrasound energy through the skull, recent advances in ultrasound technology, software, and real-time monitoring have resulted in a renewed interest in the clinical applications of transcranial FUS. Following extensive pre- clinical studies, ultrasound-induced thermal ablation has been approved by several countries for the treatment of essential tremor, Parkinson's disease, obsessive-compulsive disorder, depression, and neuropathic pain...
November 3, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29102253/square-biphasic-pulse-deep-brain-stimulation-for-essential-tremor-the%C3%A2-bip-tremor-study
#17
Sol De Jesus, Leonardo Almeida, Leili Shahgholi, Daniel Martinez-Ramirez, Jaimie Roper, Chris J Hass, Umer Akbar, Aparna Wagle Shukla, Robert S Raike, Michael S Okun
BACKGROUND: Conventional deep brain stimulation (DBS) utilizes regular, high frequency pulses to treat medication-refractory symptoms in essential tremor (ET). Modifications of DBS pulse shape to achieve improved effectiveness is a promising approach. OBJECTIVES: The current study assessed the safety, tolerability and effectiveness of square biphasic pulse shaping as an alternative to conventional ET DBS. METHODS: This pilot study compared biphasic pulses (BiP) versus conventional DBS pulses (ClinDBS)...
October 20, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29084313/safety-and-efficacy-of-focused-ultrasound-thalamotomy-for-patients-with-medication-refractory-tremor-dominant-parkinson-disease-a-randomized-clinical-trial
#18
Aaron E Bond, Binit B Shah, Diane S Huss, Robert F Dallapiazza, Amy Warren, Madaline B Harrison, Scott A Sperling, Xin-Qun Wang, Ryder Gwinn, Jennie Witt, Susie Ro, W Jeffrey Elias
Importance: Clinical trials have confirmed the efficacy of focused ultrasound (FUS) thalamotomy in essential tremor, but its effectiveness and safety for managing tremor-dominant Parkinson disease (TDPD) is unknown. Objective: To assess safety and efficacy at 12-month follow-up, accounting for placebo response, of unilateral FUS thalamotomy for patients with TDPD. Design, Setting, and Participants: Of the 326 patients identified from an in-house database, 53 patients consented to be screened...
October 30, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29076274/transcranial-mri-guided-high-intensity-focused-ultrasound-for-treatment-of-essential-tremor-a-pilot-study-on-the-correlation-between-lesion-size-lesion-location-thermal-dose-and-clinical-outcome
#19
Christian Federau, Maged Goubran, Jarrett Rosenberg, Jaimie Henderson, Casey H Halpern, Veronica Santini, Max Wintermark, Kim Butts Pauly, Pejman Ghanouni
BACKGROUND: Transcranial MR-guided high-intensity focused ultrasound (tcMRgFUS) is a promising noninvasive method to treat medication-refractory essential tremor. PURPOSE/HYPOTHESIS: To define the correlation between lesion size after ablation, thermal dose, and clinical outcome in tcMRgFUS treatment of essential tremor. STUDY TYPE: Retrospective. POPULATION/SUBJECTS/PHANTOM/SPECIMEN/ANIMAL MODEL: Eight patients with medication-refractory essential tremor were treated using a tcMRgFUS system at 3T...
October 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29076006/evaluation-of-thickness-of-retinal-nerve-fiber-layer-ganglion-cell-layer-and-choroidal-thickness-in-essential-tremor-can-eyes-be-a-clue-for-neurodegeneration
#20
Ali Zeynel Abidin Tak, Yıldızhan Şengül, Ayşe Sevgi Karadağ
The pathology of essential tremor (ET) and underlying mechanisms of the disease are still unclear, but an increasing amount of research has been conducted on the subject. Discussions are ongoing about ET's definition as a neurodegenerative disease. Optic coherence tomography (OCT) provides a window to the brain where direct visualization of central nervous system (CNS) changes may be possible, and it can help us to develop a new point of view on ET. The goal of this study was to examine OCT parameters in ET...
October 26, 2017: Acta Neurologica Belgica
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