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https://www.readbyqxmd.com/read/29779816/omega-3-supplementation-effects-on-body-weight-and-depression-among-dieter-women-with-co-morbidity-of-depression-and-obesity-compared-with-the-placebo-a-randomized-clinical-trial
#1
Seyed Ali Keshavarz, Seyed-Ali Mostafavi, Shahin Akhondzadeh, Mohammad Reza Mohammadi, Saeed Hosseini, Mohammad Reza Eshraghian, Maryam Chamari
PURPOSE: We aimed to evaluate the effects of the omega-3 supplementation on body weight and depression among women with co-morbidity of depression and obesity seeking weight reduction compared with the placebo. METHODS: Sixty five patients with co-morbidity of depression and overweight/obesity (BMI ≥ 25) signed the informed consent form and enrolled into this 12-week double-blind, placebo-controlled randomized clinical Trial. Subsequently, participants randomly assigned into one of the two groups receiving daily 6 capsules of omega-3 (each capsule containing 180 mg EPA, and 120 mg DHA) or 6 capsules of placebo (two with each meal)...
June 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29769663/endogenous-testosterone-and-exogenous-oxytocin-influence-the-response-to-baby-schema-in-the-female-brain
#2
Sarah K C Holtfrerich, Roland Pfister, Alexander T El Gammal, Eugen Bellon, Esther K Diekhof
Nurturing behavior may be critically influenced by the interplay of different hormones. The neuropeptide oxytocin is known to promote maternal behavior and its reduction has been associated with postpartum depression risk and child neglect. Contrariwise, the observed decrease in testosterone level during early parenthood may benefit caretaking behavior, whereas increased testosterone may reduce attention to infants. Here we used functional magnetic resonance imaging to investigate the interactive influence of testosterone and oxytocin on selective attention to and neural processing of the baby schema (BS)...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764293/can-a-brief-biologically-based-psychoeducational-intervention-reduce-stigma-and-increase-help-seeking-intentions-for-depression-in-young-people-a-randomised-controlled-trial
#3
Kerry A Howard, Kathleen M Griffiths, Rebecca McKetin, Jennifer Ma
There is disagreement in the literature as to whether biological attribution increases or decreases stigma. This study investigated the effect of an online biological intervention on stigma and help-seeking intentions for depression among adolescents. A three-arm, pre-post test, double-blind randomised controlled trial (RCT) was used to compare the effects of a biological and a psychosocial intervention delivered online. Participants comprised secondary school students (N = 327) aged 16-19 years. Outcome measures included anticipated self-stigma for depression (primary), personal stigma, help-seeking intention for depression, and biological and psychosocial attribution...
May 15, 2018: Journal of Child and Adolescent Mental Health
https://www.readbyqxmd.com/read/29762677/anti-dementia-drugs-for-psychopathology-and-cognitive-impairment-in-schizophrenia-a-systematic-review-and-meta-analysis
#4
Taro Kishi, Toshikazu Ikuta, Kazuto Oya, Shinji Matsunaga, Yuki Matsuda, Nakao Iwata
Background: We conducted a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials of anti-dementia drugs plus antipsychotics (ADD+AP) for schizophrenia. Methods: Primary outcomes of efficacy and safety included improving overall symptoms (Positive and Negative Syndrome Scale and Brief Psychiatric Rating Scale scores) and all-cause discontinuation, respectively. Other outcomes included psychopathology subscales (positive, negative, general, and anxiety/depressive symptoms), cognitive function (attention/vigilance, reasoning/problem solving, social cognition, speed of processing, verbal learning, visual learning, working memory, and cognitive control/executive function), Mini-Mental State Examination (MMSE) scores, treatment discontinuation due to adverse events and inefficacy, and individual adverse events...
May 14, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29757924/placebo-versus-low-dose-ketamine-infusion-in-addition-to-remifentanil-target-controlled-infusion-for-conscious-sedation-during-oocyte-retrieval-a-prospective-double-blinded-randomised-controlled-trial
#5
Hélène I Morue, Shalini Raj-Lawrence, Sarah Saxena, Anne Delbaere, Edgard Engelman, Luc A Barvais
BACKGROUND: Currently, there is no gold standard for monitored anaesthesia care during oocyte retrieval. OBJECTIVE: In our institution, the standard is a conscious sedation technique using a target-controlled infusion (TCI) of remifentanil, titrated to maintain a visual analogue pain score less than 30 mm. This protocol is well accepted by patients but is associated with frequent episodes of respiratory depression. The main objective of this study was to evaluate whether the addition of a continuous intravenous infusion of ketamine could reduce these episodes...
April 30, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29755397/stress-axis-regulation-by-vitamin-d-3-in-multiple-sclerosis
#6
Linda Rolf, Jan Damoiseaux, Inge Huitinga, Dorien Kimenai, Jody van den Ouweland, Raymond Hupperts, Joost Smolders
Introduction: Multiple sclerosis (MS) has been associated with both a poor vitamin D status and hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis. Since nuclear receptor ligands may regulate each other, we explored the association of vitamin D3 supplements with circadian cortisol levels in a double-blind and placebo-controlled supplementation study. Methods: Female patients with relapsing-remitting MS received vitamin D3 supplements (4,000 IU/day; n  = 22) or placebo ( n  = 19) during 16 weeks...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29755029/a-double-blind-placebo-controlled-trial-of-fennel-foeniculum-vulgare-on-menopausal-symptoms-a-high-placebo-response
#7
Masumeh Ghazanfarpour, Mona Najaf Najafi, Nosrat Baharian Sharghi, Mahsa Sadat Mousavi, Masoudeh Babakhanian, Hassan Rakhshanded
OBJECTIVE: The present study aimed to evaluate the oral fennel effects on the menopausal symptoms. MATERIAL AND METHODS: This double-blind, randomized, placebo-controlled trial was conducted on fifty postmenopausal women in Mashhad (Iran). Patients randomly divided into two groups of fennel ( n = 25) and placebo ( n= 25). The measurements were carried out at the baseline and after three months through Menopause-Specific Quality of Life (MENQOL) questionnaire. RESULTS: Both placebo and treatment groups revealed significant improvement in the hot flush score ( p< 0...
May 14, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29754115/delusional-misidentifications-in-a-procrustean-bed
#8
EDITORIAL
G N Christodoulou, M Margariti, N Christodoulou
The Delusional Misidentification Syndromes (DMSs) are characterized by defective integration of the normally The Delusional Misidentification Syndromes (DMSs) are characterized by defective integration of the normally fused functions of perception and recognition. The classical sub-types are: the syndromes of Capgras, Fregoli,Intermetamorphosis (mentioned in 3) and Subjective doubles. These syndromes occur in a clear sensorium and shouldbe differentiated from the banal transient misidentifications occurring in confusional states and in mania and from thenon-delusional misidentifications (e...
January 2018: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29753799/predictors-of-erectile-function-normalization-in-men-with-erectile-dysfunction-treated-with-placebo
#9
John P Mulhall, Martin Carlsson, Vera Stecher, Li-Jung Tseng
BACKGROUND: Clinical study and practice data have shown sildenafil improves sexual function in men with erectile dysfunction (ED). However, some men treated with placebo in double-blind, placebo-controlled sildenafil studies also report improved erectile function as measured by International Index of Erectile Function (IIEF)-Erectile Function Domain (EFD) scores. AIM: This analysis estimated the relationship between post-baseline IIEF-EFD scores and demographic variables, including co-morbidities, in men with ED receiving placebo in flexible-dose sildenafil studies...
May 9, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29750715/visual-field-tests-for-glaucoma-patients-with-initial-macular-damage-comparison-between-frequency-doubling-technology-and-standard-automated-perimetry-using-24-2-or-10-2-visual-fields
#10
Hae-Young Lopilly Park, Jiyoung Lee, Chan Kee Park
PURPOSE: To compare standard automated perimetry (SAP) and frequency-doubling technology (FDT) perimetry for detecting macular damage in glaucoma. METHODS: One-hundred-twelve glaucomatous eyes with localized retinal nerve fiber layer (RNFL) defects on red-free photographs and corresponding macular ganglion cell/inner plexiform layer (mGC/IPL) thinning on the deviation map of macular optical coherence tomography (OCT), and thirty-five healthy eyes were enrolled in the study...
May 10, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29750366/feasibility-and-acceptability-of-maternal-choline-supplementation-in-heavy-drinking-pregnant-women-a-randomized-double-blind-placebo-controlled-clinical-trial
#11
Sandra W Jacobson, R Colin Carter, Christopher D Molteno, Ernesta M Meintjes, Marjanne Senekal, Nadine M Lindinger, Neil C Dodge, Steven H Zeisel, Christopher P Duggan, Joseph L Jacobson
BACKGROUND: Choline, an essential nutrient, serves as a methyl-group donor for DNA methylation and is a constituent of the neurotransmitter acetylcholine and a precursor to major components of cell membranes. Findings from animal studies suggest that choline supplementation during pregnancy may mitigate adverse effects of prenatal alcohol exposure on growth and neurocognitive function. We conducted a randomized, double-blind exploratory trial to examine feasibility and acceptability of a choline supplementation intervention during pregnancy...
May 11, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29748628/7t-1-h-mrs-in-major-depressive-disorder-a-ketamine-treatment-study
#12
Jennifer W Evans, Níall Lally, Li An, Ningzhi Li, Allison C Nugent, Dipavo Banerjee, Sam L Snider, Jun Shen, Jonathan P Roiser, Carlos A Zarate
The glutamatergic modulator ketamine has striking and rapid antidepressant effects in major depressive disorder (MDD), but its mechanism of action remains unknown. Proton magnetic resonance spectroscopy (1H-MRS) is the only non-invasive method able to directly measure glutamate levels in vivo; in particular, glutamate and glutamine metabolite concentrations are separable by 1H-MRS at 7T. This double-blind, placebo-controlled, crossover study that included 1 H-MRS scans at baseline and at 24 h post ketamine and post-placebo infusions sought to determine glutamate levels in the pregenual anterior cingulate (pgACC) of 20 medication-free MDD subjects and 17 healthy volunteers (HVs) 24 h post ketamine administration, and to evaluate any other measured metabolite changes, correlates, or predictors of antidepressant response...
April 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29747716/effects-of-antiparkinson-medication-on-cognition-in-parkinson-s-disease-a-systematic-review
#13
Marc-André Roy, Maxime Doiron, Jessica Talon-Croteau, Nicolas Dupré, Martine Simard
OBJECTIVE: This study aimed to systematically review the effects of currently prescribed antiparkinson medication on cognition in patients with mild-to-moderate Parkinson's disease (PD) who were either cognitively intact or mildly impaired. METHODS: English- and French-language studies published between 1969 and 2017 were accessed via MedLine, PsychNET, EMBASE and EBSCO databases. Methodological quality (MQ) was evaluated with the quality assessment instrument of the Cochrane Collaboration Depression, Anxiety and Neurosis Review (scores from 0% to 44% indicate very low quality; scores from 45% to 64% indicate low quality; scores from 65% to 84% indicate medium quality; and scores from 85% to 100% indicate high quality)...
May 11, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29747670/the-efficacy-and-safety-of-jiedu-tongluo-granules-for-treating-post-stroke-depression-with-qi-deficiency-and-blood-stasis-syndrome-study-protocol-for-a-randomized-controlled-trial
#14
Ai-Mei Zhao, Wen-Ran Qiu, Li-Jun Mao, Jun-Guo Ren, Li Xu, Ming-Jiang Yao, Kellie Bilinksi, Dennis Chang, Jian-Xun Liu
BACKGROUND: Post-stroke depression (PSD) is the most common psychiatric complication after a stroke. The most frequently used antidepressants are selective serotonin receptor inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), however, these exhibit a series of side effects. Traditional Chinese medicine has been used to treat PSD with few side effects. The aim of this study is to evaluate the efficacy and safety of Jiedu Tongluo granules for treating PSD with qi deficiency and blood stasis syndrome...
May 10, 2018: Trials
https://www.readbyqxmd.com/read/29742460/low-grade-inflammation-decreases-emotion-recognition-evidence-from-the-vaccination-model-of-inflammation
#15
Leonie Jt Balter, Sasha Hulsken, Sarah Aldred, Mark T Drayson, Suzanne Higgs, Jet Jcs Veldhuijzen van Zanten, Jane E Raymond, Jos A Bosch
The ability to adequately interpret the mental state of another person is key to complex human social interaction. Recent evidence suggests that this ability, considered a hallmark of 'theory of mind' (ToM), becomes impaired by inflammation. However, extant supportive empirical evidence is based on experiments that induce not only inflammation but also induce discomfort and sickness, factors that could also account for temporary social impairment. Hence, an experimental inflammation manipulation was applied that avoided this confound, isolating effects of inflammation and social interaction...
May 6, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29740604/mechanism-of-the-2015-volcanic-tsunami-earthquake-near-torishima-japan
#16
Yoshio Fukao, Osamu Sandanbata, Hiroko Sugioka, Aki Ito, Hajime Shiobara, Shingo Watada, Kenji Satake
Tsunami earthquakes are a group of enigmatic earthquakes generating disproportionally large tsunamis relative to seismic magnitude. These events occur most typically near deep-sea trenches. Tsunami earthquakes occurring approximately every 10 years near Torishima on the Izu-Bonin arc are another example. Seismic and tsunami waves from the 2015 event [ M w (moment magnitude) = 5.7] were recorded by an offshore seafloor array of 10 pressure gauges, ~100 km away from the epicenter. We made an array analysis of dispersive tsunamis to locate the tsunami source within the submarine Smith Caldera...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29740273/childhood-emotional-abuse-moderates-associations-among-corticomotor-white-matter-structure-and-stress-neuromodulators-in-women-with-and-without-depression
#17
Carlton P Frost, M Elizabeth Meyerand, Rasmus M Birn, Roxanne M Hoks, Erin C Walsh, Heather C Abercrombie
Adverse caregiving during development can produce long-lasting changes to neural, endocrine, and behavioral responses to stress, and is strongly related to elevated risk of adult psychopathology. While prior experience of adversity is associated with altered sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis activity, the underlying neural pathways are not completely understood. In a double-blind crossover study, we used diffusion tensor imaging (DTI) to examine whether variation in white matter structure predicts differences in HPA-SNS interactions as a function of early adversity...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29740015/effects-of-5-aminolevulinic-acid-supplementation-on-home-based-walking-training-achievement-in-middle-aged-depressive-women-randomized-double-blind-crossover-pilot-study
#18
Hiroshi Suzuki, Shizue Masuki, Akiyo Morikawa, Yu Ogawa, Yoshi-Ichiro Kamijo, Kiwamu Takahashi, Motowo Nakajima, Hiroshi Nose
Depressive patients often experience difficulty in performing exercise due to physical and psychological barriers. We examined the effects of 5-aminolevulinic acid (ALA) with sodium ferrous citrate (SFC) supplementation during home-based walking training in middle-aged depressive women. Nine outpatients [53 ± 8 (SD) yr] with major depressive disorder participated in the pilot study with randomized, placebo-controlled, double-blind crossover design. They underwent two trials for 7 days, each performing interval walking training (IWT) with ALA + SFC (ALA + SFC) or placebo supplement intake (PLC) intermittently with >a 10-day washout period...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29738425/a-pilot-open-label-8-week-study-evaluating-desvenlafaxine-for-treatment-of-major-depression-in-methadone-maintained-individuals-with-opioid-use-disorder
#19
Cynthia El Hage, Maykel F Ghabrash, Simon Dubreucq, Suzanne Brissette, François Lespérance, Paul Lespérance, Clairélaine Ouellet-Plamondon, Julie Bruneau, Didier Jutras-Aswad
Depression is one of the most prevalent psychiatric disorders among opioid-dependent individuals. Clinical trials testing selective serotonin reuptake inhibitors among depressed patients on methadone maintenance therapy (MMT) failed to show efficacy, whereas those on tricyclic antidepressants produced mixed results with potential for cardiotoxicity. Desvenlafaxine (DESV) is a SNRI with minimal cardiotoxicity and drug interactions. This study sought to assess feasibility and tolerability of using DESV in depressed patients on MMT...
May 7, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29738424/effects-of-vaginal-estradiol-tablets-and-moisturizer-on-menopause-specific-quality-of-life-and-mood-in-healthy-postmenopausal-women-with-vaginal-symptoms-a-randomized-clinical-trial
#20
Susan J Diem, Katherine A Guthrie, Caroline M Mitchell, Susan D Reed, Joseph C Larson, Kristine E Ensrud, Andrea Z LaCroix
OBJECTIVE: Compare the effects of a vaginal estradiol tablet and a vaginal moisturizer, each to placebo, on menopause-related quality of life and mood in postmenopausal women with moderate-severe vulvovaginal symptoms. METHODS: A total of 302 postmenopausal women enrolled in a 12-week, double-blind, placebo-controlled randomized trial were assigned to vaginal 10 μg estradiol tablet plus placebo gel (n = 102), vaginal moisturizer plus placebo tablet (n = 100), or dual placebo (n = 100)...
May 7, 2018: Menopause: the Journal of the North American Menopause Society
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