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https://www.readbyqxmd.com/read/29909520/lapatinib-in-combination-with-paclitaxel-plays-synergistic-antitumor-effects-on-esophageal-squamous-cancer
#1
Xiao-Fang Guo, Sai-Sai Li, Xiao-Fei Zhu, Qiao-Hua Dou, Duan Liu
PURPOSE: Paclitaxel-based chemoradiotherapy was proven to be efficacious in treating patients with advanced esophageal cancer. However, the toxicity and the development of resistance limited its anticancer efficiency. The present study was to evaluate the antitumor effects of lapatinib, a dual tyrosine inhibitor of both epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), combined with paclitaxel on the esophageal squamous cancer. METHODS: MTT assays were used to evaluate the effects of the combination of lapatinib and paclitaxel on the growth of esophageal squamous cancer cell lines (KYSE150, KYSE450, KYSE510 and TE-7)...
June 16, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29909184/rates-causes-risk-factors-and-outcomes-of-readmission-following-deep-brain-stimulation-for-movement-disorders-analysis-of-the-u-s-nationwide-readmissions-database
#2
Kavelin Rumalla, Kyle A Smith, Kenneth A Follett, Jules M Nazzaro, Paul M Arnold
OBJECTIVE: Deep brain stimulation (DBS) surgery has proven benefit for several movement disorders and medically-refractory psychiatric conditions and is considered a fairly safe procedure. We sought to determine the national rates, causes, predictors, and outcomes associated with 30-day and 90-day readmission. PATIENTS AND METHODS: The Nationwide Readmissions Database was queried (January-September 2013) using ICD-9-CM codes, identifying patients who underwent DBS for movement disorder (Parkinson's disease [PD], essential tremor [ET], or dystonia)...
June 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29909087/critical-appraisal-of-the-quality-of-evidence-addressing-the-diagnosis-prognosis-and-management-of-peripheral-artery-disease-in-patients-with-diabetic-foot-ulceration
#3
Stephen R Ali, Baris A Ozdemir, Robert J Hinchliffe
AIMS: There is a paucity of robust evidence on prevention and management of diabetic foot ulcers (DFUs) to inform treatment. This study appraises the current quality of the evidence addressing diagnosis, prognosis, and management of peripheral artery disease (PAD) in patients with DFUs using a newly devised 21 point scoring (TOPS) disease specific research appraisal tool published by the International Working Group on the Diabetic Foot (IWGDF) and European Wound Management Association...
June 13, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29909035/bacterial-cellulose-lignin-composite-hydrogel-as-a-promising-agent-in-chronic-wound-healing
#4
Danica Zmejkoski, Dragica Spasojević, Irina Orlovska, Natalia Kozyrovska, Marina Soković, Jasmina Glamočlija, Svetlana Dmitrović, Branko Matović, Nikola Tasić, Vuk Maksimović, Mikhail Sosnin, Ksenija Radotić
Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones...
June 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29909030/preparation-and-evaluation-of-%C3%AE-glucan-hydrogel-prepared-by-the-radiation-technique-for-drug-carrier-applications
#5
Jong-Seok Park, Youn-Mook Lim, Jae Baik, Jin-Oh Jeong, Sung-Jun An, Sung-In Jeong, Hui-Jeong Gwon, Myung-Seob Khil
β-Glucan can provide excellent environment to apply to drug carrier due to its immunological and anti-inflammatory effect. Minocycline hydrochloride (MH) has excellent oral bioavailability pharmacological properties. Specifically, MH is effectively absorbed into the gingiva for periodontal disease treatment. In this study, we attempt to develop MH loaded β-glucan hydrogel for periodontal disease treatment through radiation-crosslinking technique. In addition, MH loaded β-glucan hydrogels were tested for their cytotoxicity and antibacterial activity...
June 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29908932/comparison-of-open-and-closed-hand-fractures-and-the-effect-of-urgent-operative-intervention
#6
Shobhit V Minhas, Louis W Catalano
PURPOSE: To establish and compare the incidence of 30-day postoperative infection in surgically managed open and closed metacarpal and phalangeal fractures, and to determine whether open fractures treated urgently had a lower incidence of postoperative infection. METHODS: We conducted a retrospective analysis of patient demographics, comorbidities, and 30-day infection rates of patients undergoing operative fixation of metacarpal, proximal, or middle phalanx fractures from 2008 to 2015 using the American College of Surgeons' National Surgical Quality Improvement Program database...
June 13, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29908640/comparative-study-of-regenerative-effects-of-mesenchymal-stem-cells-derived-from-placental-amnion-chorion-and-umbilical-cord-on-dermal-wounds
#7
Juliane Ertl, Melanie Pichlsberger, Alexandru-Cristian Tuca, Paul Wurzer, Jakob Fuchs, Stefan H Geyer, Barbara Maurer-Gesek, Wolfgang J Weninger, Dagmar Pfeiffer, Vladimir Bubalo, Daryousch Parvizi, Lars-Peter Kamolz, Ingrid Lang
OBJECTIVE: Mesenchymal stem/stromal cells derived from human term placentas (PMSCs) are novel therapeutic agents and more topical than ever. Here we evaluated the effects of three types of PMSCs on wound healing in an in vivo mouse model: Amnion-derived MSCs (AMSCs), blood vessel-derived MSCs (BV-MSCs) from the chorionic plate and Wharton's jelly-derived MSCs (WJ-MSCs) from the umbilical cord. METHODS: We topically applied PMSCs onto skin wounds in mice using the dermal substitute Matriderm® as carrier and evaluated wound healing parameters...
May 2018: Placenta
https://www.readbyqxmd.com/read/29908638/gadd45a-knockdown-alleviates-oxidative-stress-through-suppressing-the-p38-mapk-signaling-pathway-in-the-pathogenesis-of-preeclampsia
#8
Fa-Hong Li, Na Han, Yong Wang, Qian Xu
OBJECTIVE: Preeclampsia (PE) is a hypertensive disease associated with vascular oxidative stress (OS). Besides, cell response to OS triggers growth arrest and DNA damage inducible alpha (Gadd45a). Herein, we investigated the effect of Gadd45a on OS in PE. METHODS: Umbilical cord tissues and peripheral blood samples were collected from PE patients and normal pregnant women. Immunohistochemistry was applied to identify Gadd45a level and extent of p38 phosphorylation...
May 2018: Placenta
https://www.readbyqxmd.com/read/29908624/vaginoplasty-complications
#9
REVIEW
Cecile A Ferrando
Complications after vaginoplasty surgery for the transgender woman exist. These adverse outcomes can be minor and easily treatable, whereas others are considered major events and require ongoing care. Adverse outcomes can be immediate or remote after surgery and include bleeding, hematoma, infection, delayed wound healing, neovaginal stenosis, visceral injury, and fistula. Patients may also experience pelvic floor disorders after surgery. Providers performing these surgeries and those providers caring for postoperative patients should be aware of the incidence of these complications and the treatment options that exist to manage them...
July 2018: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/29908000/serpin-a1-and-the-modulation-of-type-i-collagen-turnover-effect-of-the-c-terminal-peptide-409-418-sa1-iii-in-human-dermal-fibroblasts
#10
Caterina Cipriani, Simona Pascarella, Fosca Errante, Beatrice Menicacci, Lucia Magnelli, Alessandra Mocali, Paolo Rovero, Lisa Giovannelli
The pharmacological modulation of collagen turnover is a strategy potentially useful in different skin conditions. The serine protease inhibitor Serpin A1 and portions of its C-terminal region have been investigated as collagen modulators. To clarify the mechanisms by which the C-terminal 409-418 peptide SA1-III increases extracellular type I collagen levels, to compare its activities range with that of the originator molecule Serpin A1, and to evaluate its efficacy in primary cultures from adult and aged human subjects...
June 16, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29907232/intramuscular-e-selectin-adeno-associated-virus-gene-therapy-promotes-wound-healing-in-an-ischemic-mouse-model
#11
Punam P Parikh, Roberta M Lassance-Soares, Hongwei Shao, Manuela M Regueiro, Yan Li, Zhao-Jun Liu, Omaida C Velazquez
BACKGROUND: Poor wound healing in critical limb ischemia (CLI) is attributed to impaired neovascularization and reperfusion. Optimizing the ischemic wound with adhesion molecules that enhance stem cell homing may revolutionize treatment. The purpose of this study is to test the efficacy of adhesion molecule E-selectin on wound healing in an ischemic mouse wound. METHODS: Adult FVB/NJ mice underwent unilateral femoral artery and vein ligation to induce CLI. A 4-mm punch biopsy wound was created on the anterior thigh to simulate ischemic wounds...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907107/complete-abdominal-wound-and-anastomotic-leak-with-diffuse-peritonitis-closure-achieved-by-an-abdominal-vacuum-sealing-drainage-in-a-critical-ill-patient-a-case-report
#12
Yusuke Fujii, Yoshitsugu Tajima, Shunsuke Kaji, Takashi Kishi, Yoshiko Miyazaki, Takahito Taniura, Noriyuki Hirahara
BACKGROUND: Negative pressure wound therapy (NPWT) is a widely accepted technique to treat local infectious wounds of the skin, subcutaneous tissue, fascia, or muscle. Recently, several reports describing the efficacy of NPWT for various types of fistulas and anastomotic leaks have been published. We herein describe a patient with an open abdominal wound due to colonic anastomotic leakage and diffuse peritonitis, in whom abdominal vacuum sealing (AVS) as a modified NPWT was useful for the management of this complex wound...
June 15, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29906614/assessing-risk-and-related-complications-after-reversal-of-combat-associated-ostomies
#13
Luke R Johnston, Matthew J Bradley, Carlos J Rodriguez, Michael P McNally, Eric A Elster, James E Duncan
BACKGROUND: During the past decade of conflict, numerous casualties sustained injuries requiring the formation of an ostomy. However, outcomes in those casualties undergoing ostomy reversal have yet to be analyzed. We review the experience and identify risk factors for complications after ostomy reversal in a series of combat casualties at our military treatment facility. STUDY DESIGN: A retrospective review of combat casualties managed with a diverting ostomy who underwent ostomy reversal at our military treatment facility over a 13 year period...
June 12, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29906322/dressings-and-topical-agents-for-treating-venous-leg-ulcers
#14
REVIEW
Gill Norman, Maggie J Westby, Amber D Rithalia, Nikki Stubbs, Marta O Soares, Jo C Dumville
BACKGROUND: Venous leg ulcers are open skin wounds on the lower leg which can be slow to heal, and are both painful and costly. The point prevalence of open venous leg ulcers in the UK is about 3 cases per 10,000 people, and many people experience recurrent episodes of prolonged ulceration. First-line treatment for venous leg ulcers is compression therapy, but a wide range of dressings and topical treatments are also used. This diversity of treatments makes evidence-based decision-making challenging, and a clear and current overview of all the evidence is required...
June 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29905629/local-vancomycin-effectively-reduces-surgical-site-infection-at-implant-site-in-rodents
#15
Jeffrey S Kroin, Jinyuan Li, Sasha Shafikhani, Kajal H Gupta, Mario Moric, Asokumar Buvanendran
BACKGROUND AND OBJECTIVES: Infected implantable devices represent a clinical challenge, because the customary option is to surgically remove the device, and that is associated with substantial cost and morbidity to the patient, along with patient dissatisfaction with the physician. Although prophylactic systemic antibiotics and sterile technique are the mainstay of prevention of surgical site infection (SSI) after implant, the incidence of SSI remains relatively high. Although some surgeons add local antibiotic at implant site during surgery, there is no scientific research to demonstrate if there is a benefit...
June 13, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29905606/the-effect-of-the-histone-deacetylase-inhibitor-suberoylanilide-hydroxamic-acid-and-paclitaxel-treatment-on-full-thickness-wound-healing-in-mice
#16
Joseph H Marcotte, Deviney A Rattigan, Robin F Irons, Kevin W Cahill, Ping Zhang, Shaohua Chang, Kiavash R Koko, John P Gaughan, Jeffrey P Carpenter, Spencer A Brown, Tulin Budak-Alpdogan
INTRODUCTION: Neoadjuvant chemotherapy prior to lumpectomy or mastectomy for breast cancer challenges wound healing. Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, has been shown to work synergistically with paclitaxel in vitro and in preclinical studies. In addition, our laboratory has demonstrated that SAHA treatment decreases paclitaxel-associated stem cell toxicity, modulates inflammatory response, and promotes wound healing in injured fibroblast cells. Our goal was to determine if combined SAHA and paclitaxel treatment would improve wound healing in an in vivo full-thickness murine model, without altering antitumor effect...
June 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29905539/-liver-cystic-echinococcosis-laparoscopic-treatment-effectiveness
#17
V Grubnik, V Iliashenko, Z Bugridze, Viqtor Grubnik, Sh Giuashvili
The main goal of the research was to study echinococcosis liver cyst laparoscopic treatment's effectiveness. The retrospective analysis of liver echinococcosis cyst surgical treatment in the period from 2003 to 2013 years was conducted. 348 patients underwent surgical treatment, among them 283 patients - laparoscopic procedure, 65 - open surgery. Medial age was 42,3±7,9 years. Female - 214, male - 134. 249 patients underwent laparoscopic partial (conservative) cystectomy, 34 - laparoscopic radical cystectomy with liver resection, 3 (1%) - conversion...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905136/ethics-of-burn-wound-care-in-a-low-middle-income-country
#18
Shelley Wall, Nikki Allorto, Ross Weale, Victor Kong, Damian Clarke
This review focuses on burn care in low- and middle-income countries (LMICs). It attempts to put the burden of disease in perspective by showing that burn care is under-resourced across the spectrum of LMICs and by interrogating the ethical dilemmas and challenges that staff face in caring for burn patients in this environment, with a focus on South Africa. More specifically, it will attempt to address the following issues: the threshold for utilizing the intensive care unit (ICU), how to balance treatment against cost, the percentage burn considered survivable and how it should be determined, the use of skin from both cadavers and living related donors, and the appropriate ethical guidelines for LMICs...
June 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29905134/problems-and-costs-that-could-be-addressed-by-improved-burn-and-wound-care-training-in-health-professions-education
#19
Patrick T Delaplain, Victor C Joe
The current system of burn care delivery attempts to meet the needs of the nearly 500 000 patients in the United States who require medical treatment annually. However, specialization of care and lack of fundamental burn and wound care knowledge among graduating medical trainees has unintended consequences, leaving the system inefficient, with inherent inequities in care delivery and with the potential to be overwhelmed in a mass casualty event. While increasing accessibility to specialty burn centers through technology could mitigate some of these problems, increased education is more practical...
June 1, 2018: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29905048/-diagnosis-and-treatment-of-crush-syndrome-of-chest-and-arm
#20
Haojie Cui, Ge Xiong, Chunlin Zhang, Zirun Xiao
Objective: To investigate pathogenesis, diagnosis, and treatment of crush syndrome of chest and arm. Methods: Between January 2010 and January 2015, 5 cases of crush syndrome of chest and arm caused by pressing oneself in a coma after CO poisoning or alcoholic intoxication were treated. There were 4 males and 1 female with an average age of 36.7 years (range, 28-46 years). Two patients involved left upper limb and chest, while the other three patients involved right upper limb and chest...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
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