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Nitric oxide AND citrulline

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https://www.readbyqxmd.com/read/29168320/pulmonary-hypertension-in-the-premature-infant-population-analysis-of-echocardiographic-findings-and-biomarkers
#1
Michael G O'Connor, Divya Suthar, Kimberly Vera, James C Slaughter, Natalie L Maitre, Steven Steele, Amy Beller, Candice D Fike, Judy L Aschner, Paul E Moore, Eric D Austin
OBJECTIVE: Extremely low gestational age neonates (ELGANs) are at risk for pulmonary hypertension (PH). We hypothesized that PH, defined by echocardiogram at 36 weeks gestational age (GA), would associate with respiratory morbidity, increased oxidant stress, and reduced nitric oxide production. STUDY DESIGN: ELGANs in the Vanderbilt fraction of the Prematurity and Respiratory Outcomes Program (PROP) who had echocardiograms at 36 ± 1 weeks GA were studied. Echocardiogram features of PH were compared with clinical characteristics as well as markers of oxidant stress and components of the nitric oxide pathway...
November 23, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29127889/nitric-oxide-and-arginase-levels-in-peri-implant-tissues-after-delayed-loading
#2
Ceren Gokmenoglu, Nurdan Ozmeric, Caglar Sungur, Raziye Sahin Bildik, Imge Erguder, Serenay Elgun
OBJECTIVE: Nitric oxide (NO) is synthesized from the conversion of L-arginine to L-citrulline by NO synthase (NOS). Arginase can compete with NOS for the common substrate L-arginine, and thus inhibit NO production. NO levels and arginase ezyme might affect the bone remodeling cycle around implants. The aim of this studywas to investigate NO and arginase levels in gingival crevicular fluid (GCF), peri-implant sulcular fluid (PISF), and saliva. MATERIALS AND METHODS: Twenty patients with one or more implants (Straumann(®); Institute Straumann AG, Basel, Switzerland) restored with fixed crown prostheses were included in the study...
October 23, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29107336/citrulline-in-health-and-disease-review-on-human-studies
#3
REVIEW
Cinzia Papadia, Sylwia Osowska, Luc Cynober, Alastair Forbes
The amino acid L-citrulline (CIT) is safely used from the neonatal period onwards in those with urea cycle defects and carbamyl phosphate synthetase or ornithine transcarbamylase deficiencies, but several lines of enquiry indicate that it might have a much wider therapeutic role. When protein intake is low and there is a catabolic state, endogenous arginine (ARG) synthesis cannot fully be met and its supplementation can prove challenging, particularly in patients with critical and multisystem illness. Supplementary CIT could constitute a safer but still focused means of delivering ARG to endothelial and immune cells as CIT is efficiently recycled into these cells and as kidneys can convert CIT into ARG...
October 16, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29077741/rna-seq-transcriptional-profiling-of-leishmania-amazonensis-reveals-an-arginase-dependent-gene-expression-regulation
#4
Juliana Ide Aoki, Sandra Marcia Muxel, Ricardo Andrade Zampieri, Maria Fernanda Laranjeira-Silva, Karl Erik Müller, Audun Helge Nerland, Lucile Maria Floeter-Winter
BACKGROUND: Leishmania is a protozoan parasite that alternates its life cycle between the sand-fly vector and the mammalian host. This alternation involves environmental changes and leads the parasite to dynamic modifications in morphology, metabolism, cellular signaling and regulation of gene expression to allow for a rapid adaptation to new conditions. The L-arginine pathway in L. amazonensis is important during the parasite life cycle and interferes in the establishment and maintenance of the infection in mammalian macrophages...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29070803/mir-193b-regulates-breast-cancer-cell-migration-and-vasculogenic-mimicry-by-targeting-dimethylarginine-dimethylaminohydrolase-1
#5
Julie-Ann Hulin, Sara Tommasi, David Elliot, Dong Gui Hu, Benjamin C Lewis, Arduino A Mangoni
Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is responsible for metabolism of an endogenous inhibitor of nitric oxide synthase (NOS), asymmetric dimethylarginine (ADMA), which plays a key role in modulating angiogenesis. In addition to angiogenesis, tumours can establish a vascular network by forming vessel-like structures from tumour cells; a process termed vasculogenic mimicry (VM). Here, we identified over-expression of DDAH1 in aggressive MDA-MB-231, MDA-MB-453 and BT549 breast cancer cell lines when compared to normal mammary epithelial cells...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037378/l-citrulline-acts-as-potential-hypothermic-agent-to-afford-thermotolerance-in-chicks
#6
Vishwajit S Chowdhury, Guofeng Han, Mohammad A Bahry, Phuong V Tran, Phong H Do, Hui Yang, Mitsuhiro Furuse
Recently we demonstrated that L-citrulline (L-Cit) causes hypothermia in chicks. However, the question of how L-Cit mediates hypothermia remained elusive. Thus, the objective of this study was to examine some possible factors in the process of L-Cit-mediated hypothermia and to confirm whether L-Cit can also afford thermotolerance in young chicks. Chicks were subjected to oral administration of L-Cit along with intraperitoneal injection of a nitric oxide synthase (NOS) inhibitor, N(G)-nitro-l-arginine methyl ester HCl (L-NAME), to examine the involvement of NO in the process of hypothermia...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29032115/toll-like-receptor-4-tlr4-impairs-nitric-oxide-contributing-to-angiotensin-ii-induced-cavernosal-dysfunction
#7
Kenia P Nunes, Gisele F Bomfim, Haroldo A Toque, Theodora Szasz, R Clinton Webb
AIM: Angiotensin II (AngII), a corpus cavernosum (CC) constrictor peptide, modulates Toll like receptor (TLR) expression, a key element of the innate immune system, contributing to impaired vascular function in pathological conditions. However, it is unknown whether TLR4 is involved in AngII-induced erectile dysfunction. In this study, we investigated whether TLR4 plays a role in cavernosal dysfunction caused by AngII upregulation. MATERIAL AND METHODS: Cavernosal smooth muscle cells (CSMC) from C57/BL6 mice were treated with AngII (0...
October 12, 2017: Life Sciences
https://www.readbyqxmd.com/read/28975394/plasma-l-arginine-levels-distinguish-pulmonary-arterial-hypertension-from-left-ventricular-systolic-dysfunction
#8
Anna Sandqvist, Jörn Schneede, David Kylhammar, Dan Henrohn, Jakob Lundgren, Mikael Hedeland, Ulf Bondesson, Göran Rådegran, Gerhard Wikström
Pulmonary arterial hypertension (PAH) is a life-threatening condition, characterized by an imbalance of vasoactive substances and remodeling of pulmonary vasculature. Nitric oxide, formed from L-arginine, is essential for homeostasis and smooth muscle cell relaxation in PAH. Our aim was to compare plasma concentrations of L-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) in PAH compared to left ventricular systolic dysfunction (LVSD) and healthy subjects. This was an observational, multicenter study comparing 21 patients with PAH to 14 patients with LVSD and 27 healthy subjects...
October 3, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28966484/simultaneous-determination-of-arginine-citrulline-and-asymmetric-dimethylarginine-in-plasma-by-reverse-phase-high-performance-liquid-chromatography
#9
P V L N Srinivasa Rao, Aparna R Bitla
BACKGROUND: Arginine, citrulline and asymmetric dimethylarginine (ADMA) are three molecules in the nitric oxide (NO) pathway which provide useful information about vascular endothelial function. ADMA accumulates with patients with chronic kidney disease (CKD) and inhibits NO synthesis. We describe the modification of a previously established method for the measurement of amino acids analysis for simultaneous detection of arginine, citrulline, and ADMA in plasma and to validate its performance in patients with CKD...
October 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28945050/decreased-nitric-oxide-serum-level-after-pituitary-adenoma-resection
#10
Daniel Babula, Anna Horecka, Dorota Luchowska-Kocot, Joanna Kocot, Jacek Kurzepa
BACKGROUND: Nitric oxide (NO) is synthesized by the conversion of Arginine (Arg) into the NO and Citrulline (Cit). Although the NO is involved into the pathogenesis of several physiological and pathological processes, the role of NO in pituitary adenomas (PA) progres-sion is not determined. Our purpose was to evaluate the relationship between NO and PA as well as the effect of tumor resection on NO metabolites level in serum. METHODS: The study group consisted of 21 patients with PA, 18 patients with macroade-nomas and 3 with microadenomas...
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28943110/therapies-for-mitochondrial-diseases-and-current-clinical-trials
#11
REVIEW
Ayman W El-Hattab, Ana Maria Zarante, Mohammed Almannai, Fernando Scaglia
Mitochondrial diseases are a clinically and genetically heterogeneous group of disorders that result from dysfunction of the mitochondrial oxidative phosphorylation due to molecular defects in genes encoding mitochondrial proteins. Despite the advances in molecular and biochemical methodologies leading to better understanding of the etiology and mechanism of these diseases, there are still no satisfactory therapies available for mitochondrial disorders. Treatment for mitochondrial diseases remains largely symptomatic and does not significantly alter the course of the disease...
September 18, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28940638/does-l-citrulline-supplementation-improve-exercise-blood-flow-in-older-adults
#12
Joaquin U Gonzales, Andrea Raymond, John Ashley, Youngdeok Kim
What is the central question of this study? Does short-term supplementation with l-citrulline in order to increase l-arginine improve exercise blood flow and peripheral dilatation responses to exercise in older adults? What is the main finding and its importance? l-Citrulline increased femoral blood flow by 11% and vascular conductance by 14% during lower-limb exercise in older men, whereas no changes were observed in older women. This modest improvement in bulk muscle blood flow in older men has implications for altering muscle metabolism that may result in enhanced exercise tolerance in older adults...
September 20, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28904082/a-relative-l-arginine-deficiency-contributes-to-endothelial-dysfunction-across-the-stages-of-the-menopausal-transition
#13
Jelena Klawitter, Kerry L Hildreth, Uwe Christians, Wendy M Kohrt, Kerrie L Moreau
Vascular endothelial function declines across the menopause transition in women. We tested the hypothesis that reduced availability of the endothelial nitric oxide synthase [eNOS] substrate L-arginine is an underlying mechanism to vascular endothelial dysfunction across menopause stages. Endothelial function (brachial artery flow-mediated dilation [FMD]) and plasma markers of L-arginine metabolism (citrulline, N(G)-mono-methyl-ւ-arginine [L-NMMA] asymmetric dimethylarginine [ADMA] and N(G)-N('G)-dimethyl-l-arginine [SDMA]), were measured in 129 women: 36 premenopausal (33 ± 7 years), 16 early- (49 ± 3 years) or 21 late- (50 ± 4 years) perimenopausal, and 21 early- (55 ± 3 years) or 35 late- (61 ± 4 years) postmenopausal...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28893245/age-dependent-redox-status-in-the-brain-stem-of-no-deficient-hypertensive-rats
#14
Miroslava Majzúnová, Zuzana Pakanová, Peter Kvasnička, Peter Bališ, Soňa Čačányiová, Ima Dovinová
BACKGROUND: The brain stem contains important nuclei that control cardiovascular function via the sympathetic nervous system (SNS), which is strongly influenced by nitric oxide. Its biological activity is also largely determined by oxygen free radicals. Despite many experimental studies, the role of AT1R-NAD(P)H oxidase-superoxide pathway in NO-deficiency is not yet sufficiently clarified. We determined changes in free radical signaling and antioxidant and detoxification response in the brain stem of young and adult Wistar rats during chronic administration of exogenous NO inhibitors...
September 11, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28877324/t786c-mutation-in-the-endothelial-nitric-oxide-synthase-gene-in-patients-with-primary-osteonecrosis
#15
Amir M Khan, Joshua Choi, Richard A Freiberg, Charles J Glueck, Naila Goldenberg, Ping Wang
Mutations in the T786C endothelial nitric oxide synthase gene (eNOS) are associated with osteonecrosis and Prinzmetal's angina. Nitric oxide is necessary for bone health and ameliorates Prinzmetal's angina. This study compared mutations of T786C eNOS in 146 patients with primary osteonecrosis, 114 patients with Prinzmetal's angina, and 83 normal control subjects. Patients with osteonecrosis had more mutant eNOS alleles than control subjects (42% vs 22%, respectively; P<.0001) but had the same number of mutant alleles as patients with Prinzmetal's angina (42% vs 41%, respectively; P=...
September 1, 2017: Orthopedics
https://www.readbyqxmd.com/read/28868581/in-human-brain-ornithine-transcarbamylase-otc-immunoreactivity-is-strongly-expressed-in-a-small-number-of-nitrergic-neurons
#16
Hans-Gert Bernstein, Hendrik Dobrowolny, Gerburg Keilhoff, Johann Steiner
There is recent evidence for ornithine transcarbamylase (OTC) expression in adult human brain. We decided to immunocytochemically map OTC throughout brain, and to further characterize OTC-immunopositive neurons. By using double immunolabeling technique for OTC and neuronal nitric oxide synthase (nNOS) OTC protein expression was revealed in a small subset of nitrergic (nNOS) neurons. Since citrulline (the reaction product of OTC) enhances the bioavailability of L-arginine, the substrate of nNOS, it is conceivable that OTC activity supports NO production in nitrergic neurons...
December 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28867511/glutamine-and-citrulline-concentrations-reflect-nitric-oxide-synthesis-in-the-human-nervous-system
#17
I Pérez-Neri, J Ramírez-Bermúdez, C Ojeda-López, S Montes, J L Soto-Hernández, C Ríos
INTRODUCTION: Although citrulline is produced by nitric oxide (NO) synthase upon activation of the NMDA glutamate receptor, nitrite and nitrate (NOx) concentration is considered the best marker of NO synthesis, as citrulline is also metabolised by other enzymes. This study analyses the correlation between human cerebrospinal fluid NOx and citrulline concentrations in order to determine the extent to which citrulline reflects NO synthesis and glutamatergic neurotransmission. METHODS: Participants were patients with acute neurological diseases undergoing lumbar puncture (n=240)...
August 31, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28826699/major-surgery-diminishes-systemic-arginine-availability-and-suppresses-nitric-oxide-response-to-feeding-in-patients-with-early-stage-breast-cancer
#18
Mariëlle P K J Engelen, V Suzanne Klimberg, Arianna Allasia, Nicolaas E P Deutz
BACKGROUND & AIMS: Plasma arginine (ARG) levels are reduced in breast cancer, suggesting diminished systemic ARG availability. ARG and its product nitric oxide (NO) are important in early postoperative recovery due to its roles in immune function and wound healing. It remains unclear whether major surgery further diminishes systemic ARG availability due to enhanced ARG catabolism and/or insufficient endogenous ARG synthesis negatively affecting NO synthesis in patients with early stage breast cancer...
August 5, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28811749/acute-cocoa-flavanols-intake-has-minimal-effects-on-exercise-induced-oxidative-stress-and-nitric-oxide-production-in-healthy-cyclists-a-randomized-controlled-trial
#19
Lieselot Decroix, Cajsa Tonoli, Danusa Dias Soares, Amandine Descat, Marie-José Drittij-Reijnders, Antje R Weseler, Aalt Bast, Wilhelm Stahl, Elsa Heyman, Romain Meeusen
BACKGROUND: Cocoa flavanols (CF) can stimulate vasodilation by improved nitric oxide (NO) synthesis and have antioxidant and anti-inflammatory capacities. This study aimed to examine whether acute CF intake can affect exercise-induced changes in antioxidant capacity, oxidative stress, inflammation and NO production, as well as exercise performance and recovery in well-trained cyclists. METHODS: Twelve well-trained male cyclists (mean ± SD age, VO2max: 30 ± 3 years, 63...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28803324/decreased-serum-l-arginine-and-l-citrulline-levels-in-major-depression
#20
S Hess, G Baker, G Gyenes, R Tsuyuki, S Newman, Jean-Michel Le Melledo
RATIONALE: It has been suggested that endothelial dysfunction caused by a decreased endothelial production of nitric oxide (NO) may contribute to the consistently observed increased risk of developing cardiovascular disease (CVD) in physically healthy patients suffering from major depression (MD). NO is a gas synthesized from Larginine (a conditionally essential amino acid) and oxygen by endothelial nitric oxide synthase (eNOS). The end products of NO production include both NO and L-citrulline...
November 2017: Psychopharmacology
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