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Nitric oxide AND supplement

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https://www.readbyqxmd.com/read/29453682/persistent-pulmonary-hypertension-and-histologic-chorioamnionitis-in-preterm-infants-controlled-study
#1
N Katz, Y Bar-Or, A Raucher-Sterrnfeld, A Tamir, D Kohelet
Persistent pulmonary hypertension (PPHN) of the newborn is one of the most challenging acute disorders of postnatal transition with substantial morbidity and mortality. The aim of the study was to find if there is an association between persistent pulmonary hypertension and histologic chorioamnionitis in preterm infants. 27 preterm infants with echocardiographic evidence of PPHN within the first 3 days of life were eligible for the study. A matched control group of 27 patients was chosen according to gestational age, date of birth, and gender...
February 16, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29444319/beneficial-effects-of-water-soluble-chestnut-castanea-sativa-mill-tannin-extract-on-chicken-small-intestinal-epithelial-cell-culture
#2
M Brus, L Gradišnik, M Trapecar, D Škorjanc, R Frangež
Feed and water supplementation with powdered hydrolyzable tannins from chestnut represents a valuable alternative strategy to antibiotics in animal nutrition. In this study, we evaluated the effects and safety of a water-soluble form of chestnut tannin (WST) in an in vitro model of chicken small intestinal epithelial cells (CSIEC). A chicken cell culture was established, and WST in concentrations of 0.025, 0.05, 0.1, and 0.2% were tested for cytotoxicity, cell proliferation, metabolic activity, production of reactive oxygen species, intracellular antioxidative potential, genotoxicity, and influence on the epithelia cell cycle...
February 12, 2018: Poultry Science
https://www.readbyqxmd.com/read/29435808/moringa-oleifera-supplemented-diet-modulates-nootropic-related-biomolecules-in-the-brain-of-stz-induced-diabetic-rats-treated-with-acarbose
#3
Ganiyu Oboh, Sunday I Oyeleye, Omoyemi A Akintemi, Tosin A Olasehinde
There are strong correlations between diabetes mellitus and cognitive dysfunction. This study sought to investigate the modulatory effects of Moringa oleifera leaf (ML) and seed (MS) inclusive diets on biomolecules [acetylcholinesterase (AChE), butyrylcholinesterase (BChE)] angiotensin-I converting enzyme (ACE), arginase, catalase, glutathione transferase (GST) and glutathione peroxidase (GSH-Px) activities, glutathione (GSH) and nitric oxide (NO) levels] associated with cognitive function in the brain of streptozotocin (STZ)-induced diabetic rats treated with acarbose (ACA)...
February 12, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29432877/the-effects-of-vitamin-d-and-probiotic-co-supplementation-on-mental-health-parameters-and-metabolic-status-in-type-2-diabetic-patients-with-coronary-heart-disease-a-randomized-double-blind-placebo-controlled-trial
#4
Fariba Raygan, Vahidreza Ostadmohammadi, Fereshteh Bahmani, Zatollah Asemi
BACKGROUND: This study was carried out to evaluate the effects of vitamin D and probiotic co-supplementation on mental health parameters and metabolic status in diabetic people with coronary heart disease (CHD). METHODS: This randomized, double-blind, placebo-controlled trial was carried out among 60 diabetic people with CHD, aged 45-85 years old. Subjects were randomly allocated into two groups to receive either 50,000 IU vitamin D every 2 weeks plus 8 × 10 9 CFU/g probiotic of Lactocare Zisttakhmir Co (n = 30) or placebo (n = 30) for 12 weeks...
February 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29432804/effects-of-long-term-nitrate-supplementation-on-carbohydrate-metabolism-lipid-profiles-oxidative-stress-and-inflammation-in-male-obese-type-2-diabetic-rats
#5
Sevda Gheibi, Sajad Jeddi, Mattias Carlström, Hanieh Gholami, Asghar Ghasemi
PURPOSE: Supplementation with inorganic nitrate to boost the nitrate-nitrite-nitric oxide (NO) pathway, may act as a potential therapeutic agent in diabetes. The aim of this study was to determine the effects of nitrate on carbohydrate metabolism, lipid profiles, oxidative stress, and inflammation in obese type 2 diabetic rats. METHODS: Male Wistar rats were divided into 4 groups: Control, control + nitrate, diabetes, and diabetes + nitrate. Diabetes was induced using a high-fat diet and low-dose of streptozotocin...
February 10, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29431536/multi-day-pomegranate-extract-supplementation-decreases-oxygen-uptake-during-submaximal-cycling-exercise-but-co-supplementation-with-n-acetylcysteine-negates-the-effect
#6
Emma M Crum, Matthew J Barnes, Stephen R Stannard
Pomegranate extract (POMx) has been suggested as an ergogenic aid, due to its rich concentration of polyphenols, which are proposed to enhance nitric oxide (NO) bioavailability, thereby improving the efficiency of oxygen usage and consequently, endurance exercise performance. Although acute POMx supplementation improves aerobic exercise performance in untrained individuals, trained athletes appear to require chronic supplementation for a similar effect. Further, the combination of POMx with a thiol antioxidant may prove more effective than POMx alone, due to the protective effects of thiols on NO...
February 12, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29431520/beneficial-effects-of-acute-trans-resveratrol-supplementation-in-treated-hypertensive-patients-with-endothelial-dysfunction
#7
B C A A Marques, M Trindade, J C F Aquino, A R Cunha, R O Gismondi, M F Neves, W Oigman
Endothelial dysfunction is a surrogate marker of cardiovascular risk. Resveratrol is known to improve endothelial function in animals, however, clinical trials are limited. We hypothesized that the acute trans-resveratrol supplementation improves endothelial function in treated hypertensive patients with endothelial dysfunction. Twenty-four hypertensive patients between 45 and 65 years-old with baseline endothelial dysfunction were enrolled in a randomized, cross-over, double-blind, placebo-controlled trial...
February 12, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29424564/oxidative-stress-impairs-cgmp-dependent-protein-kinase-activation-and-vasodilator-stimulated-phosphoprotein-serine-phosphorylation
#8
Anees A Banday, Mustafa F Lokhandwala
Reactive oxygen species induce vascular dysfunction and hypertension by directly interacting with nitric oxide (NO) which leads to NO inactivation. In addition to a decrease in NO bioavailability, there is evidence that oxidative stress can also modulate NO signaling during hypertension. Here, we investigated the effect of oxidative stress on NO signaling molecules cGMP-dependent protein kinase (PKG) and vasodilator-stimulated phosphoprotein (VASP) which are known to mediate vasodilatory actions of NO. Male Sprague Dawley (SD) rats were provided with tap water (control), 30 mM L-buthionine sulfoximine (BSO, a pro-oxidant), 1 mM tempol (T, an antioxidant) and BSO + T for 3 wks...
February 9, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29423081/pm2-5-inhalation-induces-intracranial-atherosclerosis-which-may-be-ameliorated-by-omega-3-fatty-acids
#9
Longfei Guan, Xiaokun Geng, Jiamei Shen, James Yip, Fengwu Li, Huishan Du, Zhili Ji, Yuchuan Ding
Background: Intracranial atherosclerosis (ICA) a major health problem. This study investigated whether inhalation of fine airborne particulate matters (PM2.5) causes ICA and whether omega-3 fatty acids (O3FA) attenuated the development of ICA. Results: Twelve but not 6 week exposure significantly increased triglycerides (TG) in normal chow diet (NCD), while PM2.5 enhanced all lipid profiles (TG, low density lipoprotein (LDL) and cholesterol (CHO)) after both 6 and 12-week exposure with high-cholesterol diet (HCD)...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29420996/walnut-extract-modulates-activation-of-microglia-through-alteration-in-intracellular-calcium-concentration
#10
Nopporn Thangthaeng, Shibu M Poulose, Derek R Fisher, Barbara Shukitt-Hale
Diets supplemented with walnuts have shown to protect brain against oxidative and inflammatory cytotoxicity and promote protective cellular and cognitive function. The current study was undertaken to test the hypothesize that whole walnut extract (WNE) inhibits lipopolysaccharide (LPS)-induced microglial activation by regulating calmodulin (CaM) expression through [Ca2+]i. To test this hypothesis, we used an in vitro model the highly aggressively proliferating immortalized cells, a rat microglial cell line, treated with various concentrations of WNEs...
January 2018: Nutrition Research
https://www.readbyqxmd.com/read/29419603/characteristics-of-infants-with-congenital-diaphragmatic-hernia-who-need-follow-up-of-pulmonary-hypertension
#11
Ulrike S Kraemer, Lisette Leeuwen, Thomas B Krasemann, René M H Wijnen, Dick Tibboel, Hanneke IJsselstijn
OBJECTIVES: Pulmonary hypertension is one of the main causes of mortality and morbidity in patients with congenital diaphragmatic hernia. Currently, it is unknown whether pulmonary hypertension persists or recurs during the first year of life. DESIGN: Prospective longitudinal follow-up study. SETTING: Tertiary university hospital. PATIENTS: Fifty-two congenital diaphragmatic hernia patients admitted between 2010 and 2014...
February 6, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29415069/administration-of-l-arginine-plus-l-citrulline-or-l-citrulline-alone-successfully-retarded-endothelial-senescence
#12
Tomoe Tsuboi, Morihiko Maeda, Toshio Hayashi
L-citrulline and L-arginine supplementation has been shown to have several beneficial effects on the cardiovascular system. Nitric oxide (NO) protects against the progression of atherosclerosis and is synthesized by nitric oxide synthase (NOS), which converts L-arginine (L-Arg) into L-citrulline (L-Cit). Our previous study revealed that chronic administration of a combination of L-Cit and L- Arg has a better therapeutic effect on high cholesterol-induced atherosclerosis in rabbits. We investigated how L-Arg and L-Cit affect endothelial function, aging and atherosclerosis...
2018: PloS One
https://www.readbyqxmd.com/read/29412804/testosterone-to-estrogen-conversion-is-not-responsible-for-the-vasodilating-effects-of-testosterone-ex-vivo
#13
Shijin Tan, Dong Yi, Wei Zhu, Rong Sun, Meng Wei
Men have a higher incidence of cardiovascular disease, but poorer vasodilatation than women. However, testosterone exerts vasodilating actions ex vivo. We aimed to determine if reactive oxygen species (ROS) produced in vivo could cause 'eNOS uncoupling' that accounts for the disparity between in vivo and ex vivo results. Ovariectomized SHR and WKY rats were divided into 3 groups: untreated, estradiol benzoate (EB) treated, and testosterone propionate (TP) treated. EB and TP rats were treated for 8 weeks, and blood pressure, serum estrogen, progesterone, and testosterone were measured...
January 31, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29411266/a-molecular-neurobiological-approach-to-understanding-the-aetiology-of-chronic-fatigue-syndrome-myalgic-encephalomyelitis-or-systemic-exertion-intolerance-disease-with-treatment-implications
#14
REVIEW
Jean A Monro, Basant K Puri
Currently, a psychologically based model is widely held to be the basis for the aetiology and treatment of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME)/systemic exertion intolerance disease (SEID). However, an alternative, molecular neurobiological approach is possible and in this paper evidence demonstrating a biological aetiology for CFS/ME/SEID is adduced from a study of the history of the disease and a consideration of the role of the following in this disease: nitric oxide and peroxynitrite, oxidative and nitrosative stress, the blood-brain barrier and intestinal permeability, cytokines and infections, metabolism, structural and chemical brain changes, neurophysiological changes and calcium ion mobilisation...
February 6, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29397749/a-micelle-system-based-on-molecular-economy-principle-for-overcoming-multidrug-resistance-and-inhibiting-metastasis
#15
Yan Qi, Xianya Qin, Conglian Yang, Tingting Wu, Qi Qiao, Qingle Song, Zhiping Zhang
The high mortality of cancer is mainly attributed to multidrug resistance (MDR) and metastasis. A simple micelle system was constructed here to co-deliver doxorubicin (DOX), adjudin (ADD) and nitric oxide (NO) for overcoming MDR and inhibiting metastasis. It was devised based on 'molecular economy' principle as the micelle system was easy to fabricate and exhibited high drug loading efficiency, and importantly each component of the micelles would exert one or more active functions. DOX acted as the main cell killing agent supplemented with ADD, NO and d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)...
February 4, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29394240/beneficial-effects-of-adrenal-androgen-supplement-in-bleeding-cirrhotic-rats
#16
Hui-Chun Huang, Shao-Jung Hsu, Ching-Chih Chang, Ming-Hung Tsai, Fa-Yauh Lee, Ming-Chih Hou, Shou-Dong Lee
Critical illness is accompanied by hypothalamic-pituitary-adrenal axis activation, but adrenal insufficiency characterized by inadequate glucocorticoid synthesis is common in critically ill cirrhotic patients, the 'hepato-adrenal syndrome'. Adrenal cortex also synthesizes androgen (dehydroepiandrosterone, DHEA). DHEA maintains microcirculation by enhancing vascular endothelial nitric oxide synthase (eNOS) activity. In critical patients of other disease entities, a shift of adrenal steroidogenesis away from androgens towards glucocorticoid has been noted, arousing interests in androgen replacement in critical settings...
February 1, 2018: Shock
https://www.readbyqxmd.com/read/29390203/enos-uncoupling-a-therapeutic-target-for-ischemic-foot-of-diabetic-rat
#17
Ling Gao, Ailin Yu, Jingcheng Liu, Lina Ma, Jing Li
AIM: To determine the relationship between eNOS uncoupling and diabetic ischemic foot and whether reversing eNOS uncoupling by Dihydrofolate reductase (DHFR) transfection or folic acid (FA) supplementation can be beneficiary in diabetic ischemic foot. METHODS: The bilateral common iliac artery of diabetic rats were ligated to establish the diabetic ischemic foot animal model. DHFR transfection was implemented via femoral artery and muscle injection of in vivo transfection reagent mixture (GenEscortIII) every 4 days during the 2 weeks intervention...
February 1, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29386488/effects-of-red-wine-vinegar-beverage-on-the-colonic-tissue-of-rodents-biochemical-functional-and-pharmacological-analyses
#18
Azjargal Enkhsaikhan, Akira Takahara, Yuji Nakamura, Ai Goto, Koki Chiba, Nur Jaharat Lubna, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsuhiko T Naito, Atsushi Sugiyama
A beverage made of red wine vinegar and grape juice (Yamanashi-no-megumi™) was developed as a supplemental fluid containing polyphenols, which has been clinically shown to enhance the colonic transit. In this study, we assessed the mechanism of its prokinetic action by analyzing the effects on both the colonic phosphodiesterase activity of rats (n=4) and the isolated colonic strip preparation of guinea pigs (n=4). The 7% (v/v) solution of the beverage significantly decreased the phosphodiesterase activity by 9% (n=4)...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29385475/effects-of-adding-mannan-oligosaccharides-on-digestibility-and-metabolism-of-nutrients-ruminal-fermentation-parameters-immunity-and-antioxidant-capacity-of-sheep
#19
Chen Zheng, Fadi Li, Zhengli Hao, Ting Liu
The purpose of this study was to investigate the effects of adding mannan-oligosaccharides (MOS) on the following parameters in sheep: digestibility and retention rate of nutrients, ruminal fermentation, immunity and antioxidant capacity. Twelve healthy crossbred wethers (Suffolk ♂ × Small tail Han-yang ♀) with external ruminal fistula and similar body weights (28.04 ± 2.07 kg) were fed individually 4 treatments, 3 repeats of each treatment. The wethers diets were supplemental MOS at 0%, 1.2%, 1.6% and 2...
January 29, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29379542/clinical-and-immunological-effects-of-vitamin-d-supplementation-during-the-pollen-season-in-children-with-allergic-rhinitis
#20
Joanna Jerzyńska, Włodzimierz Stelmach, Błażej Rychlik, Paweł Majak, Daniela Podlecka, Katarzyna Woicka-Kolejwa, Iwona Stelmach
Introduction: Vitamin D deficiency has been proposed as a potential contributing factor in patients with allergic diseases. We compared the clinical and immunological effects of vitamin D supplementation to placebo during the pollen season in children with allergic rhinitis. Material and methods: Thirty-eight children aged 5-12, sensitive to grass pollen, participated in a prospective, randomized, double-blind, placebo-controlled trial. Children received either vitamin D 1000 IU daily supplementation or placebo...
January 2018: Archives of Medical Science: AMS
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