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Nitric oxide AND supplement

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https://www.readbyqxmd.com/read/29671652/effects-of-educated-monocytes-with-xenogeneic-mesenchymal-stem-cell-derived-conditioned-medium-in-a-mouse-model-of-chronic-asthma
#1
Hadi Esmaili Gourvarchin Galeh, Seyyed Meysam Abtahi Froushani, Nahideh Afzale Ahangaran, Siamak Naji Hadai
BACKGROUND: This study was conducted to determine the potential of the monocytes educated with rat bone marrow mesenchymal stem cell-derived conditioned medium (MCM) in ameliorating animal model of asthma. METHODS: Chronic asthma was induced in the BALB/c mice using ovalbumin (OVA) sensitization. The monocytes were isolated from blood of mice and supplemented with 50% MCM or negative control media. After 24 h, the cells were designated as "non-educated or educated"...
April 19, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29655682/pristimerin-a-naturally-occurring-triterpenoid-attenuates-tumorigenesis-in-experimental-colitis-associated-colon-cancer
#2
Ju-Hyung Park, Jin-Kyung Kim
BACKGROUND: Pristimerin is a quinonemethide triterpenoid with anti-cancer, anti-angiogenic, anti-inflammatory and anti-protozoal activity. However, the therapeutic role of pristimerin in colitis-associated colorectal carcinogenesis is unknown. PURPOSE: We sought to examine the therapeutic effects of pristimerin on colitis-associated colon cancer induced in mice using azoxymethane (AOM)/dextran sulfate sodium (DSS). The goal was to identify the potential mechanism of action underlying the pharmacological activity of pristimerin...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29652839/selenium-rich-ricegrass-juice-improves-antioxidant-properties-and-nitric-oxide-inhibition-in-macrophage-cells
#3
Rattanamanee Chomchan, Panupong Puttarak, Adelheid Brantner, Sunisa Siripongvutikorn
Ricegrass juice ( Oryza sativa L.) was introduced as a functional food as the consumption of sprouts or seedlings has been claimed to provide high nutritive value. Selenium (Se) is a trace mineral that plays a key role in the human antioxidation scheme. Supplementation of Se into plants is one strategy to enhance plant bioactivities, and the consumption of Se plant foods may confer superior health benefits. In this study, ricegrass juice extract was analyzed for its major phenolic components. The effect of ricegrass juice extracts bio-fortified with 0, 10 and 40 mg Se/L named as RG0, RG10, and RG40, respectively, were investigated for a percentage of cell viability, changes of endogenous antioxidant enzymes, lipid peroxidation, and nitric oxide inhibition in RAW264...
April 13, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29649996/the-effects-of-synbiotic-supplementation-on-hormonal-status-biomarkers-of-inflammation-and-oxidative-stress-in-subjects-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#4
Khadijeh Nasri, Mehri Jamilian, Elham Rahmani, Fereshteh Bahmani, Maryam Tajabadi-Ebrahimi, Zatollah Asemi
BACKGROUND: To our knowledge, no reports are available indicating the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome (PCOS). This research was done to assess the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with PCOS. METHODS: This randomized double-blind, placebo-controlled trial was conducted on 60 subjects diagnosed with PCOS according to the Rotterdam criteria...
April 12, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29629028/effects-of-glutathione-s-transferase-gst-m1-and-t1-polymorphisms-on-antioxidant-vitamins-and-oxidative-stress-related-parameters-in-korean-subclinical-hypertensive-subjects-after-kale-juice-brassica-oleracea-acephala-supplementation
#5
Hye-Jin Lee, Jeong-Hwa Han, Yoo Kyoung Park, Myung-Hee Kang
BACKGROUND/OBJECTIVES: Glutathione s-transferase ( GST ) is involved in the formation of a multigene family comprising phase II detoxification enzymes, involved in the detoxification of reactive oxygen species. This study evaluated whether daily supplementation with kale juice could modulate levels of plasma antioxidant vitamins and oxidative stress-related parameters. We further examined whether this modulation was affected by combined GSTM1 and T1 polymorphisms. SUBJECTS/METHODS: Totally, 84 subclinical hypertensive patients having systolic blood pressure (BP) over 130 mmHg or diastolic BP over 85 mmHg, received 300 mL of kale juice daily for 6 weeks...
April 2018: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29627986/bacterial-cellulose-relieves-diphenoxylate-induced-constipation-in-rats
#6
Xichuan Zhai, Dehui Lin, Yan Zhao, Xingbin Yang
This study was to probe the effects of bacterial cellulose (BC) on diphenoxylate-induced constipation in rats. Administration with BC at 500 mg/kg·bw in diphenoxylate-induced constipation rats distinctly improved the carmine propulsion rate (83.5 ± 5.2%), shortened the defecating time of the first red feces (249.0 ± 23.3 min), and increased the weight of carmine red feces within 5 h (2.7 ± 1.3 g). The levels of aquaporins (AQP-2, AQP-3 and AQP-4) and inhibitory neurotransmitters (nitric oxide, nitric oxide synthetase, vasoactive intestinal peptide and arginine vasopressin) in the BC-treated groups reduced by 31...
April 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29626668/influences-of-chlorella-vulgaris-dietary-supplementation-on-growth-performance-hematology-immune-response-and-disease-resistance-in-oreochromis-niloticus-exposed-to-sub-lethal-concentrations-of-penoxsulam-herbicide
#7
Azza A A Galal, Rasha M Reda, Amany Abdel-Rahman Mohamed
Little is known regarding the impact of penoxsulam, a fluorinated benzenesulfonamid rice herbicide, on Oreochromis niloticus. Therefore, the current study was undertaken to highlight the effects of penoxsulam exposure on O. niloticus and to evaluate the advantages of Chlorella vulgaris (CV) dietary supplementation against the induced effects. The 96-h lethal concentration 50 (LC50 ) penoxsulam value for O. niloticus was estimated at 8.948 mg/L by probit analysis in a static bioassay experiment. Next, 360 healthy fish were randomly allocated into 6 treatment groups...
April 4, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29626298/l-cysteine-in-vitro-can-restore-cellular-glutathione-and-inhibits-the-expression-of-cell-adhesion-molecules-in-g6pd-deficient-monocytes
#8
Rajesh Parsanathan, Sushil K Jain
L-Cysteine is a precursor of glutathione (GSH), a potent physiological antioxidant. Excess glucose-6-phosphate dehydrogenase (G6PD) deficiency in African Americans and low levels of L-cysteine diet in Hispanics can contributes to GSH deficiency and oxidative stress. Oxidative stress and monocyte adhesion was considered to be an initial event in the progression of vascular dysfunction and atherosclerosis. However, no previous study has investigated the contribution of GSH/G6PD deficiency to the expression of monocyte adhesion molecules...
April 6, 2018: Amino Acids
https://www.readbyqxmd.com/read/29625952/effects-of-dietary-inorganic-nitrate-supplementation-on-exercise-performance-in-patients-with-heart-failure-protocol-for-a-randomized-placebo-controlled-cross-over-trial
#9
Mary N Woessner, Itamar Levinger, Christopher Neil, Cassandra Smith, Jason D Allen
BACKGROUND: Chronic heart failure is characterized by an inability of the heart to pump enough blood to meet the demands of the body, resulting in the hallmark symptom of exercise intolerance. Chronic underperfusion of the peripheral tissues and impaired nitric oxide bioavailability have been implicated as contributors to the decrease in exercise capacity in these patients. nitric oxide bioavailability has been identified as an important mediator of exercise tolerance in healthy individuals, but there are limited studies examining the effects in patients with chronic heart failure...
April 6, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29621523/effects-of-quercetin-on-heart-nitric-oxide-metabolism-in-l-name-treated-rats
#10
Valeria Calabró, María C Litterio, César G Fraga, Monica Galleano, Barbara Piotrkowski
This study investigated the effects of a quercetin-supplemented diet on the biochemical changes installed in the heart of NO-deficient rats in terms of oxidants production and NO bioavailability determinants. Sprague-Dawley rats were subjected to Nω -nitro-l-arginine methyl ester (l-NAME) treatment (360 mg/L l-NAME in the drinking water, 4 d) with or without supplementation with quercetin (4 g/kg diet). l-NAME administration led to increased blood pressure (BP) (30%), decreased nitric oxide synthase (NOS) activity (50%), and increases in NADPH oxidase (NOX)-dependent superoxide anion production (60%) and p47phox protein level (65%)...
April 2, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29614026/prenatal-metformin-therapy-attenuates-hypertension-of-developmental-origin-in-male-adult-offspring-exposed-to-maternal-high-fructose-and-post-weaning-high-fat-diets
#11
You-Lin Tain, Kay L H Wu, Wei-Chia Lee, Steve Leu, Julie Y H Chan
Widespread consumption of a Western diet, comprised of highly refined carbohydrates and fat, may play a role in the epidemic of hypertension. Hypertension can take origin from early life. Metformin is the preferred treatment for type 2 diabetes. We examined whether prenatal metformin therapy can prevent maternal high-fructose plus post-weaning high-fat diets-induced hypertension of developmental origins via regulation of nutrient sensing signals, uric acid, oxidative stress, and the nitric oxide (NO) pathway...
April 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29614025/vitamin-e-supplementation-ameliorates-newcastle-disease-virus-induced-oxidative-stress-and-alleviates-tissue-damage-in-the-brains-of-chickens
#12
Zaib Ur Rehman, Xusheng Qiu, Yingjie Sun, Ying Liao, Lei Tan, Cuiping Song, Shengqing Yu, Zhuang Ding, Muhammad Munir, Venugopal Nair, Chunchun Meng, Chan Ding
Newcastle disease (ND), characterized by visceral, respiratory, and neurological pathologies, causes heavy economic loss in the poultry industry around the globe. While significant advances have been made in effective diagnosis and vaccine development, molecular mechanisms of ND virus (NDV)-induced neuropathologies remain elusive. In this study, we report the magnitude of oxidative stress and histopathological changes induced by the virulent NDV (ZJ1 strain) and assess the impact of vitamin E in alleviating these pathologies...
April 3, 2018: Viruses
https://www.readbyqxmd.com/read/29609847/angiotensin-iv-improves-subnormothermic-machine-perfusion-preservation-of-rat-liver-graft
#13
Donia Tabka, Mohamed Bejaoui, James Javellaud, Jean-Michel Achard, Hassen Ben Abdennebi
This study aims to determine whether Angiotensin IV (Ang IV) addition to Celsior preservation solution could improve hepatic endothelium function and provide better liver protection during subnormothermic machine preservation (SMP). Two experimental models were used: In the first part of the study, rings isolated from rat hepatic artery were preserved in Celsior solution (6 h, 20 °C) with and without Ang IV (10-9  M), then, endothelium-dependent relaxation (EDR) and the concentration of acetylcholine inducing half-maximal relaxation of pre-contracted rings (EC50) were measured...
March 30, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29606742/analysis-of-no-suppressing-activity-of-strawberry-wine-supplemented-with-ball-milled-achenes
#14
Pao-Ju Lee, Tsung-Yu Tsai, Shaun Chen
Inflammation is generally thought to be involved in the development of several chronical diseases, therefore, phytochemicals to modulate immune responses has attracted great interests. The objective of the present study was to evaluate the potential anti-inflammatory effects of wine supplemented using ball-milled achene on modulating NO production and inducible nitric oxide synthase (iNOS) expression. Ball-milled achenes were added in strawberry must prior to fermentation, and the wine samples were then concentrated and extracted with water and/or ethanol prior to analysis...
April 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29596860/endothelial-dysfunction-endothelial-nitric-oxide-bioavailability-tetrahydrobiopterin-and-5-methyltetrahydrofolate-in-cardiovascular-disease-where-are-we-with-therapy
#15
REVIEW
Matthew F Yuyun, Leong L Ng, G André Ng
Homeostasis around vascular endothelium is a function of the equilibrium between the bioavailability of nitric oxide (NO) and oxidizing reactive oxygen species (ROS). Within the vascular endothelium, NO enhances vasodilatation, reduces platelet aggression and adhesion (anti-thrombotic), prevents smooth muscle proliferation, inhibits adhesion of leukocytes and expression of pro-inflammatory cytokines genes (anti-inflammatory), and counters the oxidation of low density lipoprotein (LDL) cholesterol. A shift in the equilibrium that favours NO deficiency and ROS formation leads to endothelial dysfunction and cardiovascular disease...
March 27, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29594974/emerging-therapies-for-acne-vulgaris
#16
REVIEW
Megha K Trivedi, Suzana S Bosanac, Raja K Sivamani, Larissa N Larsen
As we gain a greater understanding of acne pathogenesis, both new agents as well as new uses for established drugs are being considered for the treatment of acne vulgaris. Multiple clinical trials assessing new formulations or combinations of established acne treatments have been conducted, and novel uses of antimicrobials such as modified diallyl disulfide oxide and nitric oxide are being assessed in clinical trials. There are also a multitude of new therapies currently being studied that target the inflammatory cascade of acne pathogenesis, including sebosuppressive and anti-inflammatory phytochemicals, and  small molecule inhibitors targeting sebaceous glands and enzymes, among others...
March 29, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29589235/attenuating-effects-of-caffeic-acid-phenethyl-ester-and-betaine-on-abamectin-induced-hepatotoxicity-and-nephrotoxicity
#17
Mohamed M Abdel-Daim, Suhair A Abdellatief
Abamectin (ABM) is a widely utilized potent anthelmintic and insecticidal agent. In this study, we investigated the protective effects of caffeic acid phenethyl ester (CAPE) and betaine (BET) against ABM-induced hepatotoxicity and nephrotoxicity in rats. Forty rats were divided into five groups, receiving either oral saline solution (normal control), oral ABM at a dose of 2 mg/kg BW (1/5 LD50), CAPE (10 μmol/kg BW intraperitoneally) followed by ABM, or BET supplementation at a dose of 250 mg/kg BW followed by ABM administration, while group V rats received a combination of i...
March 27, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29589006/pretreatment-with-dihydroquercetin-a-dietary-flavonoid-protected-against-concanavalin-a-induced-immunological-hepatic-injury-in-mice-and-tnf-%C3%AE-actd-induced-apoptosis-in-hepg2-cells
#18
Jiajie Chen, Xu Sun, Tingting Xia, Qiqi Mao, Liang Zhong
We have previously demonstrated the hepatoprotective effect of dihydroquercetin (DHQ) against concanavalin A (Con A)-induced immunological hepatic injury in mice. In this study, we investigated the immunoregulatory effects of DHQ on Con A-induced liver injury in mice. DHQ administration significantly decreased the serum levels of alanine transaminase and aspartate transaminase, effectively prevented liver damage, and increased the survival rate of Con A-treated mice. Immunohistochemistry examination revealed that supplementation with DHQ obviously reduced infiltration of CD4+ and CD8+ T cells in the injured liver tissues...
March 28, 2018: Food & Function
https://www.readbyqxmd.com/read/29580081/pulmonary-hypertensive-response-of-broiler-chickens-to-arginine-and-guanidinoacetic-acid-under-high-altitude-hypoxia
#19
Behnam Ahmadipour, Mohammadreza Sharifi, Fariborz Khajali
This study assessed the preventive effects of arginine (ARG) and guanidinoacetic acid (GAA) on the incidence of pulmonary hypertension syndrome (PHS) in broiler chickens. Four isoenergetic and isonitrogenous diets were prepared, including: (i) the control, (ii) the control supplemented with 1 g/kg ARG, (iii) the control supplemented with 1 g/kg GAA, and (iv) the control supplemented with 1.5 g/kg GAA. These diets were fed to broilers (Ross 308) from day 1 to 42 post-hatch. Criteria evaluated in the experiment were growth performance, carcass characteristics, serum and blood variables, lead-II electrocardiogram, and ET-1 and iNOS gene expression in heart and lungs...
March 2018: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/29576013/omega-3-fatty-acid-supplement-reduces-activation-of-nadph-oxidase-in-intracranial-atherosclerosis-stenosis
#20
Jiamei Shen, Radhika Rastogi, Longfei Guan, Fengwu Li, Huishan Du, Xiaokun Geng, Yuchuan Ding
Objectives Intracranial atherosclerotic stenosis (ICAS) is one of the most common causes of stroke worldwide. We adapted a rat model of atherosclerosis to study brain intracranial atherosclerosis, and further investigated how omega-3 fatty acids (O3FA) attenuated the development of ICAS by reducing the generation of reactive oxygen species (ROS) and the activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) activity. Methods Adult male Sprague-Dawley rats were divided into control normal-cholesterol or high-cholesterol diet groups with or without O3FA for up to 6 weeks...
March 24, 2018: Neurological Research
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