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https://www.readbyqxmd.com/read/29156838/associations-between-dietary-folate-intake-and-risks-of-esophageal-gastric-and-pancreatic-cancers-an-overall-and-dose-response-meta-analysis
#1
Wen Liu, Heng Zhou, Yaoqi Zhu, Chaorong Tie
There are still some controversies on the association between dietary folate intake and the risk of upper gastrointestinal cancers including esophageal, gastric and pancreatic cancers. Hence, a comprehensive meta-analysis on all available literatures was performed to clarify the relationship between dietary folate intake and risks of upper gastrointestinal cancers. An electric search was performed up to December 12(th), 2016 within the PubMed, MEDLINE AND EMBASE databases. Ultimately, a total of 46 studies which evaluated the association between folate intake and risks of upper gastrointestinal cancers were included...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156501/event-rate-net-reclassification-index-and-the-integrated-discrimination-improvement-for-studying-incremental-value-of-risk-markers
#2
Maarten van Smeden, Karel G M Moons
No abstract text is available yet for this article.
December 10, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29156323/early-life-exposure-to-per-and-polyfluoroalkyl-substances-and-mid-childhood-lipid-and-alanine-aminotransferase-levels
#3
Ana M Mora, Abby F Fleisch, Sheryl L Rifas-Shiman, Jennifer A Woo Baidal, Larissa Pardo, Thomas F Webster, Antonia M Calafat, Xiaoyun Ye, Emily Oken, Sharon K Sagiv
BACKGROUND: Growing evidence suggests that exposure to per- and polyfluoroalkyl substances (PFASs) may disrupt lipid homeostasis and liver function, but data in children are limited. OBJECTIVE: We examined the association of prenatal and mid-childhood PFAS exposure with lipids and alanine aminotransferase (ALT) levels in children. METHODS: We studied 682 mother-child pairs from a Boston-area pre-birth cohort. We quantified PFASs in maternal plasma collected in pregnancy (median 9...
November 17, 2017: Environment International
https://www.readbyqxmd.com/read/29156308/modulatory-effects-of-green-tea-extract-against-the-hepatotoxic-effects-of-4-nonylphenol-in-catfish-clarias-gariepinus
#4
A H Sayed, Hamdy A M Soliman
The antioxidant role of the green tea (Camellia sinensis) extract (GTE) was examined to remedy the toxic effects of (0.2mgl(-1)) 4-nonylphenol(4-NP). Biochemical parameters, antioxidant enzymes, liver lipid peroxidation (LPO), DNA fragmentation, and apoptosis as well as histopathology of liver of African catfish Clarias gariepinus were considered. Catfishes were divided into four groups: first group (control), second group (0.2mgl(-1) of 4-NP), third group (0.2mgl(-1)of 4-NP +100mg GTE l(-1)water), and fourth group (0...
November 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29156157/continuous-gradient-temperature-raman-spectroscopy-from-100-to-40%C3%A2-c-yields-new-molecular-models-of-arachidonic-acid-and-2-arachidonoyl-1-stearoyl-sn-glycero-3-phosphocholine
#5
C Leigh Broadhurst, Walter F Schmidt, Julie K Nguyen, Jianwei Qin, Kuanglin Chao, Moon S Kim
Despite its biochemical importance, a complete Raman analysis of arachidonic acid (AA, 20:4n-6) has never been reported. Gradient temperature Raman spectroscopy (GTRS) applies the temperature gradients utilized in differential scanning calorimetry (DSC) to Raman spectroscopy, providing a straightforward technique to identify molecular rearrangements that occur near and at phase transitions. Herein we utilize the GTRS technique for AA and 1-18:0, 2-20:4n-6 phosphatidyl choline (AAPC) from cryogenic to mammalian body temperatures...
December 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29156141/one-year-unsupervised-individualized-exercise-training-intervention-enhances-cardiorespiratory-fitness-but-not-muscle-deoxygenation-or-glycemic-control-in-adults-with-type-1-diabetes
#6
Antti-Pekka E Rissanen, Heikki O Tikkanen, Anne S Koponen, Jyrki M Aho, Juha E Peltonen
Adaptations to long-term exercise training in type 1 diabetes are sparsely studied. We examined the effects of a 1-year individualized training intervention on cardiorespiratory fitness, exercise-induced active muscle deoxygenation, and glycemic control in adults with and without type 1 diabetes. Eight men with type 1 diabetes (T1D) and eight healthy men (CON) matched for age, anthropometry, and peak pulmonary O2 uptake (V̇O2peak), completed a 1-year individualized training intervention in an unsupervised real-world setting...
November 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29156004/obesity-modulates-the-association-between-systolic-blood-pressure-and-albuminuria
#7
James Fotheringham, Bisher Kawar, William McKane, Timothy Ellam
Background: Obesity is associated with albuminuria and incident kidney disease. Increased vulnerability of the glomerular microcirculation to elevated systemic blood pressure is postulated to contribute to adverse effects of obesity on the kidney. We therefore hypothesized that obesity would modulate the association between systolic blood pressure (sBP) and albuminuria. Methods: The relationship between obesity and albuminuria [fractional albumin excretion (FE alb ) or albumin:creatinine ratio (ACR)] was modelled using linear/logistic regression in the US National Health and Nutrition Examination Survey 1999-2010 cohorts ( N  = 23 710)...
May 30, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29155770/determination-of-thermodynamic-properties-of-alkaline-earth-liquid-metal-alloys-using-the-electromotive-force-technique
#8
Thomas P Nigl, Nathan D Smith, Timothy Lichtenstein, Jarrod Gesualdi, Kuldeep Kumar, Hojong Kim
A novel electrochemical cell based on a CaF2 solid-state electrolyte has been developed to measure the electromotive force (emf) of binary alkaline earth-liquid metal alloys as functions of both composition and temperature in order to acquire thermodynamic data. The cell consists of a chemically stable solid-state CaF2-AF2 electrolyte (where A is the alkaline-earth element such as Ca, Sr, or Ba), with binary A-B alloy (where B is the liquid metal such as Bi or Sb) working electrodes, and a pure A metal reference electrode...
November 3, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155663/frameworks-for-preventing-detecting-and-controlling-zoonotic-diseases
#9
Miriam L Shiferaw, Jeffrey B Doty, Giorgi Maghlakelidze, Juliette Morgan, Ekaterine Khmaladze, Otar Parkadze, Marina Donduashvili, Emile Okitolonda Wemakoy, Jean-Jacques Muyembe, Leopold Mulumba, Jean Malekani, Joelle Kabamba, Theresa Kanter, Linda Lucy Boulanger, Abraham Haile, Abyot Bekele, Meseret Bekele, Kasahun Tafese, Andrea A McCollum, Mary G Reynolds
Preventing zoonotic diseases requires coordinated actions by government authorities responsible for human and animal health. Constructing the frameworks needed to foster intersectoral collaboration can be approached in many ways. We highlight 3 examples of approaches to implement zoonotic disease prevention and control programs. The first, rabies control in Ethiopia, was implemented using an umbrella approach: a comprehensive program designed for accelerated impact. The second, a monkeypox program in Democratic Republic of the Congo, was implemented in a stepwise manner, whereby incremental improvements and activities were incorporated into the program...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29155334/respiratory-muscle-strength-is-decreased-after-maximal-incremental-exercise-in-trained-runners-and-cyclists
#10
Ferid Oueslati, Ahmed Berriri, Jan Boone, Said Ahmaidi
The respiratory muscle fatigue seems to be able to limit exercise performance and may influence the determination of maximal oxygen uptake (V̇O2max) or maximum aerobic work rate during maximal incremental test. The aim of this study was therefore to investigate whether maximal incremental exercise decreases respiratory muscle strength. We hypothesized that respiratory muscle strength (maximal pressure) will decrease after maximal incremental exercise to exhaustion. 36 runners and 23 cyclists completed a maximal incremental test on a treadmill or a cycle ergometer with continuous monitoring of expired gases...
November 16, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29155227/linking-physician-attitudes-to-their-breast-cancer-screening-practices-a-survey-of-us-primary-care-providers-and-gynecologists
#11
Archana Radhakrishnan, Sarah A Nowak, Andrew M Parker, Kala Visvanathan, Craig E Pollack
Despite changes to breast cancer screening guidelines intended to decrease screening in younger and older women, mammography rates remain high. We investigated physician attitudes towards screening younger and older women. Surveys were mailed to US primary care providers and gynecologists between May and September 2016 (871/1665, 52.3% adjusted response rate). We assessed physician (1) attitudes towards screening younger (45-49years) and older (75+ years) women and (2) recommendations for routine mammography...
November 16, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29155153/the-glp-1-response-to-glucose-does-not-mediate-beta-and-alpha-cell-dysfunction-in-hispanics-with-abnormal-glucose-metabolism
#12
Elizabeth Adams, Pauline Genter, Emma Keefe, Kevin Sandow, Virginia Gray, Jerome I Rotter, Yii-Der Ida Chen, Eli Ipp
AIMS: Glucagon-like peptide-1 (GLP-1) contributes to insulin secretion after meals. Though Hispanics have increased risk for type 2 diabetes mellitus, it is unknown if impaired GLP-1 secretion contributes to this risk. We therefore studied plasma GLP-1 secretion and action in Hispanic adults. METHODS: Hispanic (H; n=31) and non-Hispanic (nH; n=15) participants underwent an oral glucose tolerance test (OGTT). All participants were categorized by glucose tolerance into four groups: normal glucose tolerant non-Hispanic (NGT-nH; n = 15), normal glucose tolerant Hispanic (NGT-H; n = 12), impaired glucose tolerant Hispanic (IGT-H; n = 11), or newly diagnosed type 2 diabetes mellitus, Hispanic (T2D-H; n = 8)...
November 16, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29154736/lactobacilli-fermented-cow-s-milk-attenuated-lipopolysaccharide-induced-neuroinflammation-and-memory-impairment-in-vitro-and-in-vivo
#13
Nurul Huda Musa, Vasudevan Mani, Siong Meng Lim, Sharmili Vidyadaran, Abu Bakar Abdul Majeed, Kalavathy Ramasamy
Nutritional interventions are now recommended as strategies to delay Alzheimer's disease (AD) progression. The present study evaluated the neuroprotective effect (anti-inflammation) of lactic acid bacteria (either Lactobacillus fermentum LAB9 or L. casei LABPC) fermented cow's milk (CM) against lipopolysaccharide (LPS)-activated microglial BV2 cells in vitro. The ability of CM-LAB in attenuating memory deficit in LPS-induced mice was also investigated. ICR mice were orally administered with CM-LAB for 28 d before induction of neuroinflammation by LPS...
November 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/29154431/association-between-electrocardiographic-and-echocardiographic-markers-of-stage-b-heart-failure-and-cardiovascular-outcome
#14
Hong Yang, Thomas H Marwick, Ying Wang, Mark Nolan, Kazuaki Negishi, Faisal Khan, Peter M Okin
AIMS: The detection of non-ischaemic (mainly hypertension, diabetes, and obesity) stage B heart failure (SBHF) may facilitate the recognition of those at risk of progression to overt HF and HF prevention. We sought the relationship of specific electrocardiographic (ECG) markers of SBHF to echocardiographic features of SBHF and their prognostic value for development of HF. The ECG markers were Cornell product (Cornell-P), P-wave terminal force in lead V1 (PTFV1), ST depression in lead V5 V6 (minSTmV5V6), and increased heart rate...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29154410/predicting-success-of-methotrexate-treatment-by-pretreatment-hcg-level-and-24-hour-hcg-increment
#15
Gabriel Levin, Narjes A Saleh, Rani Haj-Yahya, Liat S Matan, Avi Benshushan
OBJECTIVE: To evaluate β-human chorionic gonadotropin (β-HCG) level and its 24-hour increment as predictors of successful methotrexate treatment for ectopic pregnancy. METHODS: Data were retrospectively reviewed from women with ectopic pregnancy who were treated by single-dose methotrexate (50 mg/m(2) ) at a university hospital in Jerusalem, Israel, between January 1, 2000, and June 30, 2015. Serum β-HCG before treatment and its percentage increment in the 24 hours before treatment were compared between treatment success and failure groups...
November 20, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29154379/proposed-in-training-electrocardiogram-interpretation-competencies-for-undergraduate-and-postgraduate-trainees
#16
Pavel Antiperovitch, Wojciech Zareba, Jonathan S Steinberg, Ljuba Bacharova, Larisa G Tereshchenko, Jeronimo Farre, Kjell Nikus, Takanori Ikeda, Adrian Baranchuk
Despite its importance in everyday clinical practice, the ability of physicians to interpret electrocardiograms (ECGs) is highly variable. ECG patterns are often misdiagnosed, and electrocardiographic emergencies are frequently missed, leading to adverse patient outcomes. Currently, many medical education programs lack an organized curriculum and competency assessment to ensure trainees master this essential skill. ECG patterns that were previously mentioned in literature were organized into groups from A to D based on their clinical importance and distributed among levels of training...
November 8, 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/29154285/prediction-of-alzheimer-s-dementia-in-patients-with-amnestic-mild-cognitive-impairment-in-clinical-routine-incremental-value-of-biomarkers-of-neurodegeneration-and-brain-amyloidosis-added-stepwise-to-cognitive-status
#17
Catharina Lange, Per Suppa, Uwe Pietrzyk, Marcus R Makowski, Lothar Spies, Oliver Peters, Ralph Buchert
The aim of this study was to evaluate the incremental benefit of biomarkers for prediction of Alzheimer's disease dementia (ADD) in mild cognitive impairment (MCI) when added stepwise in the order of their collection in clinical routine. The model started with cognitive status characterized by the ADAS-13 score. Hippocampus volume (HV), cerebrospinal fluid (CSF) phospho-tau (pTau), and the FDG t-sum score in an AD-meta region-of-interest were compared as neurodegeneration markers. CSF-Aβ1-42 was used as amyloidosis marker...
November 14, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29154269/early-and-persistent-o-glcnac-protein-modification-in-the-streptozotocin-model-of%C3%A2-alzheimer-s-disease
#18
João Paulo Almeida Dos Santos, Adriana Vizuete, Fernanda Hansen, Regina Biasibetti, Carlos-Alberto Gonçalves
 O-GlcNAc transferase (OGT), an enzyme highly expressed in brain tissue, catalyzes the addition of N-acetyl-glucosamine (GlcNAc) to hydroxyl residues of serine and threonine of proteins. Brain protein O-GlcNAcylation is diminished in Alzheimer's disease (AD), and OGT targets include proteins of the insulin-signaling pathway (e.g., insulin receptor susbtrate-1, IRS-1). We hypothesized that ICV streptozotocin (STZ) also affects O-GlcNAc protein modification. We investigated hippocampal metabolic changes in Wistar rats, particularly OGT levels and insulin resistance, as well as related astroglial activities, immediately after ICV STZ administration (first week) and later on (fourth week)...
November 16, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29153741/left-atrial-function-in-patients-with-light-chain-amyloidosis-a-transthoracic-3d-speckle-tracking-imaging-study
#19
Dania Mohty, Vincent Petitalot, Julien Magne, Bahaa M Fadel, Cyrille Boulogne, Dounia Rouabhia, Chahrazed ElHamel, David Lavergne, Thibaud Damy, Victor Aboyans, Arnaud Jaccard
BACKGROUND: Systemic light chain amyloidosis (AL) is characterized by the extracellular deposition of amyloid fibrils. Transthoracic echocardiography is the modality of choice to assess cardiac function in patients with AL. Whereas left ventricular (LV) function has been well studied in this patient population, data regarding the value of left atrial (LA) function in AL patients are lacking. In this study, we aim to examine the impact of LA volumes and function on survival in AL patients as assessed by real-time 3D echocardiography...
November 16, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29153740/cost-effectiveness-of-transcatheter-aortic-valve-implantation-in-patients-with-aortic-stenosis-in-japan
#20
Satoshi Kodera, Arihiro Kiyosue, Jiro Ando, Issei Komuro
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is a less invasive treatment for elderly patients with aortic stenosis. However, the cost of TAVI is a major issue. This study analyzed the cost effectiveness of TAVI in Japan. METHODS: We developed an economic model to evaluate the quality-adjusted life years (QALYs) and costs of TAVI, surgical aortic valve replacement (SAVR), and medical therapy over a 10-year time horizon from the perspective of Japanese public healthcare payers...
November 16, 2017: Journal of Cardiology
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