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https://www.readbyqxmd.com/read/28088713/the-effects-of-utterance-timing-and-stimulation-of-left-prefrontal-cortex-on-the-production-of-referential-expressions
#1
Jennifer E Arnold, Nazbanou Nozari
We examined the relationship between the timing of utterance initiation and the choice of referring expressions, e.g., pronouns (it), zeros (…and went down), or descriptive NPs (the pink pentagon). We examined language production in healthy adults, and used anodal transcranial direct current stimulation (tDCS) to test the involvement of the left prefrontal cortex (PFC) in the timing of utterance production and the selection of reference forms in a discourse context. Twenty-two subjects (11 anodal, 11sham) described fast-paced actions, e...
January 12, 2017: Cognition
https://www.readbyqxmd.com/read/28088304/mechanical-biomarkers-of-medial-compartment-knee-osteoarthritis-diagnosis-and-severity-grading-discovery-phase
#2
Neila Mezghani, Youssef Ouakrim, Alexandre Fuentes, Amar Mitiche, Nicola Hagemeister, Pascal-André Vendittoli, Jacques A de Guise
OBJECTIVE: To investigate, as a discovery phase, if 3D knee kinematics assessment parameters can serve as mechanical biomarkers, more specifically as diagnostic biomarker and burden of disease biomarkers, as defined in the Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic classification scheme for osteoarthritis (OA) (Altman et al., 1986). These biomarkers consist of a set of biomechanical parameters discerned from 3D knee kinematic patterns, namely, flexion/extension, abduction/adduction, and tibial internal/external rotation measurements, during gait recording...
December 29, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28088087/ethylene-biosynthesis-and-perception-during-ripening-of-loquat-fruit-eriobotrya-japonica-lindl
#3
E Alos, A Martinez-Fuentes, C Reig, C Mesejo, M J Rodrigo, M Agustí, L Zacarías
In order to gain insights into the controversial ripening behavior of loquat fruits, in the present study we have analyzed the expression of three genes related to ethylene biosynthesis (ACS1, ACO1 and ACO2), two ethylene receptors (ERS1a and ERS1b), one signal transduction component (CTR1) and one transcription factor (EIL1) in peel and pulp of loquat fruit during natural ripening and also in fruits treated with ethylene (10μLL(-1)) and 1-MCP (10μLL(-1)), an ethylene action inhibitor. In fruits attached to or detached from the tree, a slight increase in ethylene production was detected at the yellow stage, but the respiration rate declined progressively during ripening...
December 19, 2016: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28088041/the-role-of-the-ifg-and-psts-in-syntactic-prediction-evidence-from-a-parametric-study-of-hierarchical-structure-in-fmri
#4
William Matchin, Christopher Hammerly, Ellen Lau
Sentences encode hierarchical structural relations among words. Several neuroimaging experiments aiming to localize combinatory operations responsible for creating this structure during sentence comprehension have contrasted short, simple phrases and sentences to unstructured controls. Some of these experiments have revealed activation in the left inferior frontal gyrus (IFG) and posterior superior temporal sulcus (pSTS), associating these regions with basic syntactic combination. However, the wide variability of these effects across studies raises questions about this interpretation...
December 18, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28087564/right-ventricular-ejection-fraction-is-incremental-to-left-ventricular-ejection-fraction-for-the-prediction-of-future-arrhythmic-events-in-patients-with-systolic-dysfunction
#5
Yoko Mikami, Umjeet Jolly, Bobak Heydari, Mingkai Peng, Fahad Almehmadi, Mohammed Zahrani, Mahmoud Bokhari, John Stirrat, Carmen P Lydell, Andrew G Howarth, Raymond Yee, James A White
BACKGROUND: Left ventricular ejection fraction remains the primary risk stratification tool used in the selection of patients for implantable cardioverter defibrillator therapy. However, this solitary marker fails to identify a substantial portion of patients experiencing sudden cardiac arrest. In this study, we examined the incremental value of considering right ventricular ejection fraction for the prediction of future arrhythmic events in patients with systolic dysfunction using the gold standard of cardiovascular magnetic resonance...
January 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28087551/cost-effectiveness-of-superficial-femoral-artery-endovascular-interventions-in-the-uk-and-germany-a-modelling-study
#6
Benjamin C Kearns, Steven M Thomas
OBJECTIVES: To assess the lifetime costs and cost-effectiveness of 5 endovascular interventions to treat superficial femoral arterial disease. DESIGN: A model-based health economic evaluation. An existing decision analytical model was used, with updated effectiveness data taken from the literature, and updated costs based on purchasing prices. SETTING: UK and German healthcare perspectives were considered. PARTICIPANTS: Patients with intermittent claudication of the femoropopliteal arteries eligible for endovascular treatment...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28087548/early-lens-extraction-with-intraocular-lens-implantation-for-the-treatment-of-primary-angle-closure-glaucoma-an-economic-evaluation-based-on-data-from-the-eagle-trial
#7
Mehdi Javanbakht, Augusto Azuara-Blanco, Jennifer M Burr, Craig Ramsay, David Cooper, Claire Cochran, John Norrie, Graham Scotland
OBJECTIVE: To investigate the cost-effectiveness of early lens extraction with intraocular lens implantation for the treatment of primary angle closure glaucoma (PACG) compared to standard care. DESIGN: Cost-effectiveness analysis alongside a multicentre pragmatic two-arm randomised controlled trial. Patients were followed-up for 36 months, and data on health service usage and health state utility were collected and analysed within the trial time horizon. A Markov model was developed to extrapolate the results over a 5-year and 10-year time horizon...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28087423/is-middle-cerebral-artery-doppler-related-to-neonatal-and-2-year-infant-outcome-in-early-fetal-growth-restriction
#8
Tamara Stampalija, Birgit Arabin, Hans Wolf, Caterina M Bilardo, Christoph Lees
BACKGROUND: Reduced fetal middle cerebral artery Doppler impedance is associated with hypoxemia in fetal growth restriction. It remains unclear as to whether this finding could be useful in timing delivery especially in third trimester. In this regard there is a paucity of evidence from prospective studies. OBJECTIVES: The aim of this study was to determine whether there is an association between middle cerebral artery Doppler impedance and its ratio with the umbilical artery in relation to neonatal and 2-year infant outcome in early fetal growth restriction (26(+0)-31(+6) weeks of gestation)...
January 10, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28087331/different-age-dependent-performance-in-drosophila-wild-type-canton-s-and-the-white-mutant-w1118-flies
#9
Shuang Qiu, Chengfeng Xiao, R Meldrum Robertson
Aging has significant effects on the locomotor performance of insects including Drosophila. Using a protocol for the high-throughput analysis of fly locomotion in a restricted space, we re-examined age-dependent behavioral characteristics in adult Drosophila. There are multiple important wild-type and background lines including the Canton-S strain and the w1118 strain, which has a null mutation of the white gene. Under standard rearing conditions, we found similar survival curves and median lifespans in Canton-S (50days) and w1118 (54days) strains, however, w1118 flies maintained stable body mass for up to 43days, whereas Canton-S flies gained body mass at young age, followed by a gradual decline...
January 10, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28087234/interference-from-related-actions-in-spoken-word-production-behavioural-and-fmri-evidence
#10
Greig de Zubicaray, Douglas Fraser, Kori Ramajoo, Katie McMahon
Few investigations of lexical access in spoken word production have investigated the cognitive and neural mechanisms involved in action naming. These are likely to be more complex than the mechanisms involved in object naming, due to the ways in which conceptual features of action words are represented. The present study employed a blocked cyclic naming paradigm to examine whether related action contexts elicit a semantic interference effect akin to that observed with categorically related objects. Participants named pictures of intransitive actions to avoid a confound with object processing...
January 10, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28086892/pressure-ulcer-image-segmentation-technique-through-synthetic-frequencies-generation-and-contrast-variation-using-toroidal-geometry
#11
Ortiz P David, Daniel Sierra-Sosa, Begoña García Zapirain
BACKGROUND: Pressure ulcers have become subject of study in recent years due to the treatment high costs and decreased life quality from patients. These chronic wounds are related to the global life expectancy increment, being the geriatric and physical disable patients the principal affected by this condition. Injuries diagnosis and treatment usually takes weeks or even months by medical personel. Using non-invasive techniques, such as image processing techniques, it is possible to conduct an analysis from ulcers and aid in its diagnosis...
January 6, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28081591/new-perspectives-of-biomarkers-for-the-management-of-chronic-hepatitis-b
#12
REVIEW
Chih-Lin Lin, Jia-Horng Kao
With recent advances in molecular and genomic investigations, the impact of hepatitis B viral and host factors on the progression of chronic HBV infection has been explored. For viral factors, hepatitis B viral load is a strong predictor for liver disease progression. Hepatitis B viral kinetics appear to be important for successful anti-viral therapy. Serum HBsAg level serves as a complementary marker to viral load for the prediction of HBV-related adverse outcomes in patients with low viral load. In those with low viral load, high serum HBsAg level is associated with higher risks of cirrhosis and HCC...
December 2016: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28081434/implicit-attitudes-towards-risky-driving-development-and-validation-of-an-affect-misattribution-procedure-for-speeding
#13
Andrei Rusu, Paul Sârbescu, Daniela Moza, Alexandra Stancu
The present study aimed to develop and validate an instrument for measuring implicit attitudes towards speeding, based on the Affect Misattribution Procedure (AMP). The data collected from 140 drivers supported the reliability of the AMP (α=0.80). Results provided some support for the construct validity of the AMP, through its convergence with explicit attitudes towards speeding (r=0.22). Also, the AMP incrementally predicted driving violations (ΔR(2)=0.034) and traffic accidents (ΔR(2)=0.022), above and beyond demographic variables and explicit attitudes towards speeding, thus providing initial evidence for its criterion validity...
January 9, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28081164/economic-evaluation-of-pcsk9-inhibitors-in-reducing-cardiovascular-risk-from-health-system-and-private-payer-perspectives
#14
Alejandro Arrieta, Timothy F Page, Emir Veledar, Khurram Nasir
The introduction of Proprotein covertase subtilisin/kexin type 9 (PCSK9) inhibitors has been heralded as a major advancement in reducing low-density lipoprotein cholesterol levels by nearly 50%. However, concerns have been raised on the added value to the health care system in terms of their costs and benefits. We assess the cost-effectiveness of PCSK9 inhibitors based on a decision-analytic model with existing clinical evidence. The model compares a lipid-lowering therapy based on statin plus PCSK9 inhibitor treatment with statin treatment only (standard therapy)...
2017: PloS One
https://www.readbyqxmd.com/read/28079842/increased-erythrocyte-aggregation-and-oxidative-stress-in-patients-with-idiopathic-interstitial-pneumonia
#15
Erhan Ugurlu, Emine Kilic-Toprak, Goksel Altinisik, Ozgen Kilic-Erkek, Betul Cengiz, Vural Kucukatay, Hande Senol, Ismail Hakki Akbudak, Yusuf Ekbic, Melek Bor-Kucukatay
BACKGROUND: Hemorheological properties are important determinants of tissue oxygenation. Although hemorheological alterations in various lung diseases have been well-defined, no information is available about the effects of idiopathic interstitial pneumonia (IIP) on hemorheological parameters. OBJECTIVES: The aim of this study was to investigate hemorheological parameters (erythrocyte deformability, aggregation, and plasma viscosity -PV) and associated oxidative stress indices in patients with IIP...
December 23, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/28079557/dobutamine-aggravates-haemodynamic-deterioration-induced-by-pleural-effusion-a-randomised-controlled-porcine-study
#16
Kristian B Wemmelund, Anders H Sørensen, Viktor K Ringgård, Erik Sloth, Peter Juhl-Olsen
BACKGROUND: Pleural effusion is a common finding in critically ill patients and may contribute to circulatory instability and the need for inotropic support. OBJECTIVE: We hypothesised that dobutamine would affect the physiological determinants preload, afterload, contractility and changes of inferior vena cava characteristics during experimental pleural effusion. DESIGN: A randomised, controlled laboratory study. SETTING: Animal laboratory, conducted from March 2013 to May 2013...
January 11, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28079358/cellulose-nanofibril-aerogels-synergistic-improvement-of-hydrophobicity-strength-and-thermal-stability-via-cross-linking-with-diisocyanate
#17
Feng Jiang, You-Lo Hsieh
A facile gelation cross-linking approach was devised to fabricate meso- and macroporous cellulose nanofibril (CNF) aerogels with multiple improved properties. CNF hydrogels made using a freezing-thawing method with a 94 kPa modulus were solvent exchanged with acetone and then cross-linked with methylene diphenyl diisocyanate (MDI) to produce aerogels with significantly improved compressive properties that follow a power law increment against aerogel density with impressive 1.69, 2.49, and 1.43 scaling factors for Young's modulus, yield stress, and ultimate stress, respectively...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28078878/vitamin-a-decreases-after-a-maximal-incremental-stress-test-in-non-professional-male-runners-with-low-aerobic-performance
#18
P Izzicupo, B Ghinassi, M A D'Amico, T Bucciarelli, S Gallina, A Di Baldassarre
The data on the effects of aerobic training on plasma antioxidant vitamins are conflicting. Additionally, most studies focus on the oxidative profiles of professional athletes, but limited information is available for amateur athlete populations. The aim of this study was to evaluate the effects of high-intensity exercise on antioxidant vitamins in non-professional runners with varying levels of aerobic power. Eighty-one male runners underwent an incremental test to exhaustion. The study population was then divided into the following tertiles according to VO2max: Group L (LowVO2max, less than 44...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28078557/cost-effectiveness-analysis-of-universal-screening-for-carbapenemase-producing-enterobacteriaceae-in-hospital-inpatients
#19
L Lapointe-Shaw, T Voruganti, P Kohler, H-H Thein, B Sander, A McGeer
The purpose of this study was to assess the cost-effectiveness of screening all hospital inpatients for carbapenemase-producing Enterobacteriaceae (CPE) at the time of hospital admission, compared to not screening, from a US hospital perspective. We used a linked transmission/Markov model to compare outcomes for a typical hospitalized medical patient, from a community with a colonization prevalence of 0.05%. Outcomes were number of colonized patients, CPE-related clinical infections and deaths, expected quality-adjusted life years (QALYs), cost, and the incremental cost-effectiveness ratio (ICER)...
January 11, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28078510/relationship-between-framingham-risk-score-and-subclinical-atherosclerosis-in-carotid-plaques-an-in-vivo-study-using-multi-contrast-mri
#20
Feiyu Li, Xiaoying Wang
The assessment and management of early-stage atherosclerosis are important for the prevention of cardiovascular disease (CVD). In this study, we used multi-contrast magnetic resonance imaging (MRI) to investigate the carotid plaque feature in asymptomatic, at-risk subjects; we also evaluated the correlation between MRI findings and Framingham risk score (FRS). One hundred sixty-six asymptomatic individuals with risk factors for CVD underwent multi-contrast MRI. After the arterial morphology and plaque components were outlined, the differences in carotid plaque burden among the various risk categories were analyzed...
January 4, 2017: Science China. Life Sciences
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