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Ang 2 AND hydration

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https://www.readbyqxmd.com/read/26648243/metal-metal-interactions-in-trinuclear-copper-ii-complexes-cu3-rcoo-4-h2tea-2-and-binuclear-cu2-rcoo-2-h2tea-2-syntheses-and-combined-structural-magnetic-high-field-electron-paramagnetic-resonance-and-theoretical-studies
#1
Andrew Ozarowski, Carmen J Calzado, Raj Pal Sharma, Santosh Kumar, Julia Jezierska, Celestino Angeli, Federico Spizzo, Valeria Ferretti
The trinuclear [Cu3(RCOO)4(H2TEA)2] copper(II) complexes, where RCOO(-) = 2-furoate (1), 2-methoxybenzoate (2), and 3-methoxybenzoate (3, 4), as well as dimeric species [Cu2(H2TEA)2(RCOO)2]·2H2O, have been prepared by adding triethanolamine (H3TEA) at ambient conditions to hydrated Cu(RCOO)2 salts. The newly synthesized complexes have been characterized by elemental analyses, spectroscopic techniques (IR and UV-visible), magnetic susceptibility, single crystal X-ray structure determination and theoretical calculations, using a Difference Dedicated Configuration Interaction approach for the evaluation of magnetic coupling constants...
December 21, 2015: Inorganic Chemistry
https://www.readbyqxmd.com/read/26111765/angiotensin-ii-modification-by-decomposition-products-of-linoleic-acid-derived-lipid-hydroperoxide
#2
Ryo Takahashi, Takaaki Goto, Tomoyuki Oe, Seon Hwa Lee
Polyunsaturated fatty acids are highly susceptible to oxidation induced by reactive oxygen species and enzymes, leading to the formation of lipid hydroperoxides. The linoleic acid (LA)-derived hydroperoxide, 13-hydroperoxyoctadecadienoic acid (HPODE) undergoes homolytic decomposition to reactive aldehydes, 4-oxo-2(E)-nonenal (ONE), 4-hydroxy-2(E)-nonenal, trans-4,5-epoxy-2(E)-decenal (EDE), and 4-hydroperoxy-2(E)-nonenal (HPNE), which can covalently modify peptides and proteins. ONE and HNE have been shown to react with angiotensin (Ang) II (DRVYIHPF) and modify the N-terminus, Arg(2), and His(6)...
September 5, 2015: Chemico-biological Interactions
https://www.readbyqxmd.com/read/25712045/intermolecular-interaction-and-the-extended-wormlike-chain-conformation-of-chitin-in-naoh-urea-aqueous-solution
#3
Yan Fang, Bo Duan, Ang Lu, Maili Liu, Huili Liu, Xiaojuan Xu, Lina Zhang
The intra- and intermolecular interactions of chitin in NaOH/urea aqueous system were studied by a combination of NMR measurements (including (13)C NMR, (23)Na NMR, and (15)N NMR) and differential scanning calorimetry. The results revealed that the NaOH and chitin formed a hydrogen-bonded complex that was surrounded by the urea hydrates to form a sheath-like structure, leading to the good dissolution. The optimal concentration range, in which chitin was molecularly dispersed in NaOH/urea aqueous, was found to investigate the chain conformation in the dilute solution with a combination of static and dynamic light scattering...
April 13, 2015: Biomacromolecules
https://www.readbyqxmd.com/read/24638221/teaching-neuroimages-a-dangerous-complication-of-spontaneous-intracranial-hypotension
#4
Claudio Tana, Massimo Caulo, Emmanuele Tafuri, Angelo Di Vincenzo, Marco Tana, Maria Vittoria De Angelis, Andrea Mezzetti, Maria Adele Giamberardino
A 43-year-old man presented with a nontraumatic orthostatic headache, spatial disorientation, and visual hallucinations ("colored flames"). General and neurologic examination were normal. Turbo spin echo T2-weighted MRI showed bilateral subdural fluid collection and venous sinus engorgement (figure, A), suggesting spontaneous intracranial hypotension (SIH). Two subdural hematomas were also found, the biggest (2.5 cm) with mass effect in the left hemisphere (figure, B). Spine MRI identified a small radicular cyst emerging from the left T1-T2 foramen as the putative cause of CSF leakage (figure, C and D)...
March 18, 2014: Neurology
https://www.readbyqxmd.com/read/23004572/use-of-surface-properties-to-control-the-growth-and-differentiation-of-mouse-fetal-liver-stem-progenitor-cell-colonies
#5
Hsuan-Ang Tsai, Chia-Ning Shen, Ying-Chih Chang
Multilayers of poly-l-lysine/poly-l-glutamic acid (PLL/PLGA) were constructed by layer-by-layer deposition on an end-tethered cationic PLL brush film serving as an initial layer. Increasing the number of coupling layers increased the thickness and the hydration of the films, and decreased the films' shear modulus and serum adsorption. These films were used to culture primary mouse fetal liver cells. Fetal liver stem/progenitor cells (FLSPCs) were isolated and maintained on the PLGA-terminal PLL/PLGA surfaces, forming colonies with clear boundaries that were partially attached to the surface, with cross-sectional areas of ~500 to ~2500 μm(2) after 2 days culture...
November 12, 2012: Biomacromolecules
https://www.readbyqxmd.com/read/22692427/effects-of-a-herbal-ergogenic-drink-on-cycling-performance-in-young-cyclists
#6
F K Ooi, R Singh, R G Sirisinghe, B Ang, S Jamalullail
It is essential to replace fluids lost so as to remain well hydrated during exercise. The intake of fluids is considered a physiological ergogenic aid to enhance exercise performance. There are currently several products in the market that are believed to have ergogenic properties which act as fluid replacement drinks during exercise. One such drink available in the Malaysian market is 'AgroMas®' herbal drink whose efficacy is yet to be proven. The purpose of this study was, therefore, to evaluate the effects of acute ingestion of this herbal drink (H) or a coloured water placebo (P) on cycling performance...
March 2001: Malaysian Journal of Nutrition
https://www.readbyqxmd.com/read/22275828/nanomedicine-for-glaucoma-liposomes-provide-sustained-release-of-latanoprost-in-the-eye
#7
Jayaganesh V Natarajan, Marcus Ang, Anastasia Darwitan, Sujay Chattopadhyay, Tina T Wong, Subbu S Venkatraman
PURPOSE: To report the development and therapeutic evaluation of a liposomal nanocarrier for sustained release of latanoprost, in the rabbit eye. METHODS: We fabricated latanoprost-loaded egg-phosphatidylcholine (EggPC) liposomes using the film hydration technique. The delivery vehicles were nano-sized (Z avg = 109 ± 18 nm), had a narrow poly dispersity index (PDI = 0.19 ± 0.04), and a very high loading efficiency (94% ± 5%). Based on in vitro data, we evaluated this formulation for lowering intraocular pressure (IOP) in rabbit eyes...
2012: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/22222281/effect-of-tulbaghia-violacea-on-the-blood-pressure-and-heart-rate-in-male-spontaneously-hypertensive-wistar-rats
#8
Ismaila A Raji, Pierre Mugabo, Kenechukwu Obikeze
ETHNOPHARMACOLOGICAL RELEVANCE: Tulbaghia violacea Harv. (Alliaceae) is a small bulbous herb which belongs to the family Alliaceae, most commonly associated with onions and garlic. In South Africa, this herb has been traditionally used in the treatment of various ailments, including fever, colds, asthma, paralysis, hypertension and stomach problems. The aim of this study was to evaluate the effect of methanol leaf extracts (MLE) of Tulbaghia violacea on the blood pressure (BP) and heart rate (HR) in anaesthetized male spontaneously hypertensive rats; and to find out the mechanism(s) by which it acts...
March 6, 2012: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/22097910/generation-of-singlet-oxygen-by-the-glyoxal-peroxynitrite-system
#9
Júlio Massari, Rita Tokikawa, Danilo B Medinas, José P F Angeli, Paolo Di Mascio, Nilson A Assunção, Etelvino J H Bechara
Diacetyl, methylglyoxal, and glyoxal are α-dicarbonyl catabolites prone to nucleophilic additions of amino groups of proteins and nucleobases, thereby triggering adverse biological responses. Because of their electrophilicity, in aqueous medium, they exist in a phosphate-catalyzed dynamic equilibrium with their hydrate forms. Diacetyl and methylglyoxal can be attacked by peroxynitrite (k(2) ≈ 1.0 × 10(4) M(-1) s(-1) and k(2) ≈ 1.0 × 10(5) M(-1) s(-1), respectively), a potent biological nucleophile and oxidant, yielding the acetyl radical from the homolysis of peroxynitrosocarbonyl adducts, and acetate or formate ions, respectively...
December 28, 2011: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/21931735/sustained-release-of-an-anti-glaucoma-drug-demonstration-of-efficacy-of-a-liposomal-formulation-in-the-rabbit-eye
#10
Jayaganesh V Natarajan, Sujay Chattopadhyay, Marcus Ang, Anastasia Darwitan, Selin Foo, Ma Zhen, Magdalene Koo, Tina T Wong, Subbu S Venkatraman
Topical medication remains the first line treatment of glaucoma; however, sustained ocular drug delivery via topical administration is difficult to achieve. Most drugs have poor penetration due to the multiple physiological barriers of the eye and are rapidly cleared if applied topically. Currently, daily topical administration for lowering the intra-ocular pressure (IOP), has many limitations, such as poor patient compliance and ocular allergy from repeated drug administration. Poor compliance leads to suboptimal control of IOP and disease progression with eventual blindness...
2011: PloS One
https://www.readbyqxmd.com/read/21058987/dehydration-electrolyte-imbalances-and-renin-angiotensin-aldosterone-vasopressin-axis-in-successful-and-unsuccessful-endurance-horses
#11
A Muñoz, C Riber, P Trigo, C Castejón-Riber, F M Castejón
REASON FOR PERFORMING STUDY: Limited information exists concerning the defence of homeostasis during endurance competitions and the relationship with performance. OBJECTIVES: This research analysed renin (REN), angiotensin II (ANG), aldosterone (ALD) and vasopressin (AVP) in horses covering different distances, assesses differences between successful and eliminated horses and evaluates correlations between hydration status, renal function, electrolytes, REN, ANG, ALD and AVP...
November 2010: Equine Veterinary Journal. Supplement
https://www.readbyqxmd.com/read/20961141/mechanically-magnetically-and-rotationally-aligned-membrane-proteins-in-phospholipid-bilayers-give-equivalent-angular-constraints-for-nmr-structure-determination
#12
Sang Ho Park, Bibhuti B Das, Anna A De Angelis, Mario Scrima, Stanley J Opella
The native environment for membrane proteins is the highly asymmetric phospholipid bilayer, and this has a large effect on both their structure and dynamics. Reproducing this environment in samples suitable for spectroscopic and diffraction experiments is a key issue, and flexibility in sample preparation is essential to accommodate the diverse size, shape, and other physical properties of membrane proteins. In most cases, to ensure that the biological activities are maintained, this means reconstituting the proteins in fully hydrated planar phospholipid bilayers...
November 11, 2010: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/20483358/central-angiotensin-ii-stimulates-cutaneous-water-intake-behavior-via-an-angiotensin-ii-type-1-receptor-pathway-in-the-japanese-tree-frog-hyla-japonica
#13
Sho Maejima, Norifumi Konno, Kouhei Matsuda, Minoru Uchiyama
Angiotensin II (Ang II) stimulates oral water intake by causing thirst in all terrestrial vertebrates except anurans. Anuran amphibians do not drink orally but absorb water osmotically through ventral skin. In this study, we examined the role of Ang II on the regulation of water-absorption behavior in the Japanese tree frog (Hyla japonica). In fully hydrated frogs, intracerebroventricular (ICV) and intralymphatic sac (ILS) injection of Ang II significantly extended the residence time of water in a dose-dependent manner...
August 2010: Hormones and Behavior
https://www.readbyqxmd.com/read/19286753/role-of-oxidative-stress-in-the-natriuresis-induced-by-central-administration-of-angiotensin-ii
#14
Anita Israel, Jorge Arzola, Sara De Jesús, Maider Varela
INTRODUCTION: Central administration of angiotensin II (Ang II) is known to reduce urinary volume and to increase sodium and potassium excretion. Recently, a novel signalling mechanism for Ang II in the periphery has been shown to involve reduced nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase-derived reactive oxygen species (ROS).Although ROS are now known to be involved in numerous Ang II-regulated processes in peripheral tissues, and are increasingly implicated in CNS neurodegenerative diseases, the role of ROS in central regulation of Ang II-induced hydromineral metabolism remains unexplored...
March 2009: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/18272252/central-angiotensin-ii-induces-sodium-bicarbonate-intake-in-the-rat
#15
Richard B David, José V Menani, Laurival A De Luca
The aim of this work was to test mineral preference in hydrated rats that received a pulse intracerebroventricular (icv(p)) injection of ANG II at a dipsogenic dose (50 ng). The icv(p) ANG II induced a four-fold higher ingestion of 0.15M NaHCO(3) than of other mineral solutions at palatable concentrations (0.15M NaCl, 0.05 mM CaCl(2) and 0.01 M KCl) in a five-bottle test with water available in a fifth bottle; water intake was not consistently high in this test. Contrary to what is predicted by the mineralocorticoid/angiotensin II synergy hypothesis, the 0...
July 2008: Appetite
https://www.readbyqxmd.com/read/16022518/one-electron-reduction-of-aqueous-nitric-oxide-a-mechanistic-revision
#16
Sergei V Lymar, Vladimir Shafirovich, Gregory A Poskrebyshev
The pulse radiolysis of aqueous NO has been reinvestigated, the variances with the prior studies are discussed, and a mechanistic revision is suggested. Both the hydrated electron and the hydrogen atom reduce NO to yield the ground-state triplet (3)NO(-) and singlet (1)HNO, respectively, which further react with NO to produce the N(2)O(2)(-) radical, albeit with the very different specific rates, k((3)NO(-) + NO) = (3.0 +/- 0.8) x 10(9) and k((1)HNO + NO) = (5.8 +/- 0.2) x 10(6) M(-)(1) s(-)(1). These reactions occur much more rapidly than the spin-forbidden acid-base equilibration of (3)NO(-) and (1)HNO under all experimentally accessible conditions...
July 25, 2005: Inorganic Chemistry
https://www.readbyqxmd.com/read/12563566/stimulation-of-collagen-gel-contraction-by-angiotensin-ii-and-iii-in-cardiac-fibroblasts
#17
Paul Lijnen, Victor Petrov, Kandelaria Rumilla, Robert Fagard
OBJECTIVE: The aim of the present study was to investigate whether angiotensin II (Ang II), angiotensin III (Ang III) or Ang II (2-8), angiotensin IV (Ang IV) or Ang II (3-8) and Ang II (1-7), Ang II (4-8), Ang II (5-8) and Ang II (1-4) can stimulate collagen gel contraction in cardiac fibroblasts in serum-free conditions. METHODS: Cardiac fibroblasts (from male adult Wistar rats) from passage 2 were cultured to confluency and added to a hydrated collagen gel in a Dulbecco's Modified Eagle's Medium, with or without foetal bovine serum, for one, two or three days...
September 2002: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/12213298/forebrain-circumventricular-organs-mediate-salt-appetite-induced-by-intravenous-angiotensin-ii-in-rats
#18
Michael J Morris, Wendy L Wilson, Elizabeth M Starbuck, Douglas A Fitts
Two circumventricular organs, the subfornical organ (SFO) and organum vasculosum laminae terminalis (OVLT), may mediate salt appetite in response to acute intravenous infusions of angiotensin (ANG) II. Fluid intakes and mean arterial pressures were measured in rats with sham lesions or electrolytic lesions of the SFO or OVLT during an intravenous infusion of 30 ng/min ANG II. Beginning 21 h before the 90-min infusion, the rats were depleted of sodium with furosemide and given a total of 300 mg/kg captopril in 75 ml/kg water in three spaced gavages to block the usual salt appetite and to hydrate the rats...
September 13, 2002: Brain Research
https://www.readbyqxmd.com/read/11882632/soluble-epoxide-hydrolase-inhibition-lowers-arterial-blood-pressure-in-angiotensin-ii-hypertension
#19
John D Imig, Xueying Zhao, Jorge H Capdevila, Christophe Morisseau, Bruce D Hammock
Epoxyeicosatrienoic acids (EETs) have antihypertensive properties and play a part in the maintenance of renal microvascular function. A novel approach to increase EET levels is to inhibit epoxide hydrolase enzymes that are responsible for conversion of biologically active EETs to dihydroxyeicosatrienoic acids (DHETs) that are void of effects on the preglomerular vasculature. We hypothesized that inhibition of soluble epoxide hydrolase (sEH) would lower blood pressure in angiotensin II (Ang II) hypertension...
February 2002: Hypertension
https://www.readbyqxmd.com/read/8238623/antidipsogenic-actions-of-endothelins-are-exerted-via-the-endothelin-a-receptor-in-the-brain
#20
W K Samson, T C Murphy
The receptor subtype mediating the antidipsogenic effects of the endothelins (ETs) was determined in conscious, unrestrained, normally hydrated rats. Intracerebroventricular injection of 6, 12, and 20 ng ET-2 resulted in a significant, dose-related inhibition of water drinking in response to subsequent injection of 100 pmol angiotensin II (ANG II). Pretreatment with 50 or 100 ng ET-B receptor agonist failed to alter the subsequent drinking response to ANG II. Drinking in response to ANG II was significantly accentuated in rats pretreated with 50, 100, and 200 ng of the selective ET-A receptor antagonist BQ-123...
November 1993: American Journal of Physiology
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